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Data Sheet Metabolomics Discovery Panel

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Data Sheet Metabolomics Discovery Panel Data Sheet Metabolomics Discovery Panel DHMRI’s Metabolomics Discovery Panel can facilitate your research needs in global profiling analysis, with our in-house library providing excellent coverage of metabolites involved in primary metabolism. Primary metabolic processes are critical for maintaining cellular homeostasis via conversion of energy sources to key building blocks for secondary metabolites and macromolecules such as proteins, lipids, nucleic acids etc., and the clearance of resulting waste products. Our untargeted analysis of in vivo or in vitro derived samples provides an overview of this metabolic landscape where fluctuations or patterns can provide valuable insight into complex, life-sustaining biochemical reactions associated with: • Growth • Development • Reproduction • Structural Maintenance • Environmental Responses DHMRI’s Discovery Panel is an ideal tool to support research and development in any Analytical Method area concerned with evaluation, diagnosis, Dual-platform MS methodology utilizing both or perturbation of critical metabolic states positive and negative ion mode UPLC-QTOF- for Pharmaceutical, Biotechnology, Food, MS coupled with two-dimensional GC-MS. Nutrition, and AgBiotech applications associated with: Observations • Diet The Metabolomics Discovery Panel allows for • Exercise the identification of up to 600 metabolites. • Disease Specific observations depend on the sample • Product efficacy and impact, including: submitted, especially those where metabolic • Therapeutics perturbation or physiological dysfunction • Foods & Food Additives may be present. • Supplements Library The Metabolomics Discovery Panel contains 600 individual compounds listed alphabetically in the pages below. Classes of compounds covered by the platform include: • Carboxylic Acids, Amino Acids • Biogenic Amines, Polyamines • Nucleotides, Co-Enzymes & Vitamins • Mono- and Disaccharides • Fatty Acids, Lipids, Steroids & Hormones Two-dimensional GC-MS 150 Research Campus Drive, Kannapolis, NC 28081 www.dhmri.org +1 704-250-2600 [email protected] Data Sheet Data Reporting and Visualization One of the challenges when undertaking biological pathway, but as a “signature” the interpretation of complex metabolomics indicative of a metabolic perturbation across datasets is the visualization of the data multiple pathways. for identification of biological significance. To aid in data visualization and reporting, Patterns can emerge among groups of DHMRI can provide access to the powerful metabolites not necessarily from a single MarkerLab® data evaluation software. Bar plot Volcano plot Pathway maps DHMRI Metabolomics Discovery Panel Compounds • (2-Aminoethyl)Phosphonate • 2-Oxobutanoate • 3-Methylhistamine • 1,3-Diaminopropane • 2-Phosphoglycerate • 3-Nitrotyrosine • 10-Hydroxydecanoate • 2-Propenoate • 3-Phosphoglycerate • 1-Aminocyclopropanecarboxylate • 2-Quinolinecarboxylate • 3-Sulfinoalanine • 1-Hydroxy-2-Naphthoate • 2-Undecanone • 4-Acetamidobutanoate • 1-Methyladenosine • 3-(2-Hydroxyphenyl)Propanoate • 4-Aminobenzoate • 1-Methylhistidine • 3-(4-Hydroxyphenyl)Pyruvate • 4-Coumarate • 1-Methylnicotinamide • 3,4 Dihydroxymandelate • 4-Guanidinobutanoate • 1-Phenylethanol • 3,4-Dihydroxybenzoate • 4-Hydroxy-3-Methoxyphenylglycol • 2,3-Butanediol • 3,4-Dihydroxyphenylacetate • 4-Hydroxybenzaldehyde • 2,3-Diaminopropionate • 3,4-Dihydroxyphenylglycol • 4-Hydroxybenzoate • 2,3-Dihydroxybenzoate • 3,5-Diiodothyronine • 4-Hydroxyphenylglycine • 2’,4’-Dihydroxyacetophenone • 3,5-Diiodotyrosine • 4-Imidazoleacetate • 2,4-Dihydroxypteridine • 3-Amino-4-Hydroxybenzoate • 4-Methylcatechol • 2,5-Dihydroxybenzoate • 3-Amino-5-Hydroxybenzoate • 4-Pyridoxate • 2,5-Dimethylpyrazine • 3-Dehydroshikimate • 4-Quinolinecarboxylate • 2,6-Dihydroxypyridine • 3-Hydroxy-3-Methylglutaryl-CoA • 5,6 Dimethylbenzimidazole • 25-Hydroxycholesterol • 3-Hydroxyanthranilate • 5-Aminolevulinate • 2-Acetamido-2-Deoxy-Beta-D-Glucosylamine • 3-Hydroxybenzaldehyde • 5-Aminopentanoate • 2-Aminoisobutyrate • 3-Hydroxybenzoate • 5’-Deoxyadenosine • 2-Aminophenol • 3-Hydroxybenzyl Alcohol • 5-Hydroxyindoleacetate • 2-Deoxyglucose • 3-Hydroxybutanoate • 5-Hydroxylysine • 2-Hydroxy-4-(Methylthio)Butanoate • 3-Hydroxymethylglutarate • 5-Hydroxytryptophan • 2-Hydroxybutyrate • 3-Hydroxyphenylacetate • 5-Methylcytosine • 2-Hydroxyphenylacetate • 3-Methoxy-4-Hydroxymandelate • 5-Valerolactone • 2-Hydroxypyridine • 3-Methoxytyramine • 6-Carboxyhexanoate • 2-Methoxyethanol • 3-Methoxytyrosine • 6-Hydroxydopamine • 2-Methylbutanal • 3-Methyl-2-Oxindole • 6-Hydroxynicotinate • 2-Methylglutarate • 3-Methyl-2-Oxovalerate • 6-Phosphogluconate • 2-Methylmaleate • 3-Methyladenine • 7-Dehydrocholesterol • 2-Methylpropanal • 3-Methylcrotonyl-CoA • Acetoacetate 150 Research Campus Drive, Kannapolis, NC 28081 www.dhmri.org +1 704-250-2600 [email protected] Data Sheet • Acetoin • Carnitine • Deoxyguanosine Triphosphate • Acetylcholine • Carnosine • Deoxyribose • Acetylphosphate • CDP-Ethanolamine • Deoxyuridine • Adenine • Cellobiose • Deoxyuridine Monophosphate • Adenosine • Chenodeoxycholate • Deoxyuridine Triphosphate • Adenosine 2’,3’-Cyclic Phosphate • Cholate • Desmosterol • Adenosine 3’,5’-Diphosphate • Cholesteryl Oleate • Dethiobiotin • Adenosine Diphosphate • Cholesteryl Palmitate • Diacetyl • Adenosine Diphosphate Ribose • Choline • Diaminopimelate • Adenosine Monophosphate • Cis-4-Hydroxy-D-Proline • Didecanoyl-Glycerophosphocholine • Adenosine Triphosphate • Citicoline • Diethanolamine • Adenosine Triphosphate • Citramalate • Diethyl 2-Methyl-3-Oxosuccinate • Adipate • Citrate • Dihydrobiopterin • ADP-Glucose • Citrulline • Dihydrofolate • Agmatine Sulfate • Coenzyme A • Dihydroorotate • AICAR • Coenzyme Q10 • Dihydrouracil • Alanine • Cortexolone • Dihydroxyacetone phosphate • Allantoin • Corticosterone • Dihydroxyfumarate • Allose • Cortisol • Dipalmitoylglycerol • Allothreonine • Cortisol 21-Acetate • Dipalmitoyl-Phosphatidylcholine • Allyl Isothiocyanate • Cortisone • Dipalmitoyl-Phosphoethanolamine • Alpha-D-Glucose • Creatine • Docosahexaenoate • Alpha-Hydroxyisobutyrate • Creatinine • Dopamine • Alpha-Tocopherol • Cyanocobalamin • D-Ornithine • Aminoadipate • Cyclic AMP • dTDP-Glucose • Aminoisobutanoate • Cyclic GMP • D-Tryptophan • Aniline • Cyclopentanone • Eicosapentaenoate • Aniline-2-Sulfonate • Cystathionine • Elaidate • Anserine • Cysteamine • Epinephrine • Anthranilate • Cysteate • Erucate • Arabinose • Cysteine • Erythritol • Arabitol • Cysteinylglycine • Estradiol-17Alpha • Arachidate • Cystine • Ethanolamine • Arginine • Cytidine • Ethanolamine Phosphate • Ascorbate • Cytidine 2’,3’-Cyclic Phosphate • Ethyl 3-Indoleacetate • Asparagine • Cytidine Diphosphate • Ethyl 3-Ureidopropionate • Aspartate • Cytidine Monophosphate • Ethylmalonate • Azelate • Cytidine Monophosphate • Ferulate • Benzaldehyde • Cytidine Triphosphate • Flavin Adenine Dinucleotide • Benzoate • Cytochrome C • Folate • Benzyl Alcohol • Cytosine • Formamide • Benzylamine • D-Alanine • Fructose • Beta-Alanine • D-Aspartate • Fructose 6-Phosphate • Beta-Carotene • Decanoate • Fructose Bisphosphate • Beta-Glycerophosphate • Dehydroascorbate • Fucose • Betaine • Deoxyadenosine • Fumarate • Beta-Nicotinamide Adenine Dinucleotide • Deoxyadenosine Monophosphate • Galactarate • Bilirubin • Deoxyadenosine Triphosphate • Galactitol • Biliverdin • Deoxycarnitine • Galactosamine • Biotin • Deoxycholate • Galactose • Bis(2-Ethylhexyl)phthalate • Deoxycorticosterone Acetate • Galactose 1-Phosphate • Butanoate • Deoxycytidine • Galacturonate • Cadaverine • Deoxycytidine Diphosphate • Gamma,Gamma-Dimethylallyl Pyrophosphate • Caffeate • Deoxycytidine Monophosphate • Gamma-Aminobutyrate • Caffeine • Deoxyguanosine • Gamma-Linolenate • Caprylate • Deoxyguanosine Diphosphate • Geranyl Diphosphate • Carbamoyl Phosphate • Deoxyguanosine Monophosphate • Gluconate 150 Research Campus Drive, Kannapolis, NC 28081 www.dhmri.org +1 704-250-2600 [email protected] Data Sheet • Gluconolactone • Indole-3-Acetamide • Methyglutarate • Glucosaminate • Indole-3-Acetate • Methyl 4-Aminobutyrate • Glucosamine • Indole-3-Ethanol • Methyl Acetoacetate • Glucosamine 6-Phosphate • Indole-3-Methyl Acetate • Methyl Galactoside • Glucosamine 6-Sulfate • Indole-3-Pyruvate • Methyl Jasmonate • Glucose 1-Phosphate • Indoleacetaldehyde • Methyl Vanillate • Glucose 6-Phosphate • Indoxyl Sulfate • Methylguanidine • Glucuronate • Inosine • Methylmalonate • Glucuronolactone • Inosine Diphosphate • Methylthioadenosine • Glutamine • Inosine Monophosphate • Mevalolactone • Glutarate • Inosine Triphosphate • Mevalonate • Glutarylcarnitine • Isobutyrate • Monoethylmalonate • Glutathione Reduced • Isocitrate • Monomethylglutarate • Glyceraldehyde • Isoleucine • Myoinositol • Glyceraldehyde 3-Phosphate • Isopentenyl Pyrophosphate • Myristate • Glycerate • Itaconate • N,N-Dimethyl-1,4-Phenylenediamine • Glycerol • Ketoleucine • N,N-Dimethylarginine • Glycerol 3-Phosphate • Kynurenate • N1-Acetylspermine • Glycerol-Myristate • Kynurenine • N6-(Delta2-Isopentenyl)-Adenine • Glyceryl Trimyristate • Lactate • N-Acetylalanine • Glyceryl Tripalmitate • Lactose • N-Acetylasparagine • Glycine • Lanosterol • N-Acetylaspartate • Glycochenodeoxycholate • Laurate • N-Acetylcysteine • Glycocholate • Lauroylcarnitine • N-Acetylgalactosamine • Glycolaldehyde • L-DOPA • N-Acetylglucosamine • Glycolate • Leucine • N-Acetylglutamate • Glyoxylate • L-Gulonolactone • N-Acetylglycine • Guaiacol • Linoleate • N-Acetylleucine • Guanidinoacetate • Liothyronine • N-Acetylmannosamine
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