grey matters 2008-2010 Report neuro

1 CONTENTS

1 Great Memories Great Future 2 Message from the Director Administration 5 Neuro Advisory Board: Minding our Future 6 Campaign Cabinet 2007-2012: Thinking Ahead Director 7 Raising The Neuro’s Profile David R. Colman, PhD 8 Faculty: Our World-class Thinkers Associate Directors 9 New Faculty at The Neuro: Added Brainpower Mark Angle, MD 10 Faculty Awards and Distinctions: Great Minds, Great Achievements Philip Barker, PhD 13 Nurses: Our Nerve Centre Robert Dunn, PhD 14 CECR Award: Brainwaves Thomas Gevas 16 Sharing Insights Worldwide: Minds over Matter Elizabeth Kofron, PhD 18 Patient Services: Better Lives Ahead Donatella Tampieri, MD 20 Thinking Ahead: The Power of Philanthropy Administrative Director 25 The Neuro Annual Fund: Surpassing the $1 Million Milestone Neuroscience Mission, MNH 26 Compassion: What it Takes to Give Martine Alfonso 28 Financial Summary 30 In Memoriam Associate Director of Nursing, 32 The Neuro at a Glance neuroscience Patricia O’Connor, RN, MSc(A), CHE1 Lucia Fabijan, BN, MSc(A) 1 Director of Nursing & Chief Nursing Officer at the McGill University Health Centre as of October 2009. Executive Director, External Affairs Catherine Rowe, CFRE

Editor Sandra McPherson, PhD Design & production cgcom.com The Montreal Neurological Institute is proud to be a The editor would like to acknowledge the work of photographer Owen Egan Killam Institution, supported and the staff of Neuro Media Services. by the Killam Trusts. In 1966, Thanks to the faculty and staff of the Izaak Walton Killam The Neuro and donors and volunteers Memorial Endowment Fund for contributing images used in this report. and Fund for Advanced Studies were established This report covers the period June 1, 2007 at the Montreal Neurological to May 31, 2010. Institute through the bequest of Dorothy Johnston Killam. Le rapport est disponible en français. These funds support the academic and training Montreal Neurological Institute and Hospital mission of the Institute, and 3801 University Street are invaluable to advancing Montreal, Quebec H3A 2B4 our work in neuroscience. External Affairs: Tel.: 514 398-1902 Fax: 514 398-8072 [email protected] www.theneuro.com

2 GREAT MEMORIES GREAT FUTURE Celebrating 75 Years at The Neuro

2009-2010 marked The Neuro’s 75th Anniversary. As we fast-forward into the future, we celebrate a history rich in innovation and discovery, uniting outstanding research and compassionate patient care. In 1934, Dr. Wilder Penfield charted a future where Montreal would give the world hope for conditions ranging from migraines to stroke to Parkinson’s disease. As the first to map key functional regions of the living brain, Dr. Penfield inspired creativity in all who came to The Neuro to study the brain and care for patients with neurological and neurosurgical conditions. Today, The Neuro’s clinicians, researchers and former fellows around the world continue to break new ground. Seventy-five years of evolution have created an organization that is stronger than ever and stands as a model for institutions around the world.

“It’s all about excellence in the tradition of research. This is truly one of the institutes, if one looks at all of Canada’s health research fields together, that is recognized world-wide for the quality of the science conducted here. The other aspect is that this science is completely focused on the brain—all aspects of the brain. From the molecule to functioning and thinking, in other words neuropsychology. As a result, the entire range of brain functions is under scrutiny. What is unique at the Neuro is the way this research is integrated with patient care. And the benefits are not only from laboratory to patient, but also from patient to laboratory. In other words, the research findings are applied to patient care and help improve the health of all Canadians.” – Alain Beaudet President, Canadian Institutes of Health Research

Celebrating The Neuro’s 75th Anniversary celebrations (from left to right): CIHR President Dr. Alain Beaudet, McGill Dean of Medicine Dr. Richard Levin, MUHC CEO Dr. Arthur Porter, Neuro Director Dr. David Colman, Premier Jean Charest, McGill Principal Heather Munroe-Blum, OC and Former Alcan CEO and Campaign Co-Chair for The Neuro’s Thinking Ahead campaign, Mr. Jacques Bougie, OC.

“When travelling abroad, I meet people who talk to me about the Neuro. Not everyone at home real- izes that the Neuro is a one of the world’s top institutions. In fact, it is one reason why Montreal is recognized globally as a life sciences research centre. And that inspires us; it drives us in our university hospital initiatives, because we Heather Hiscox (right), host of CBC News: Morning and member want to maintain Quebec’s position, of the Neuro’s Advisory Board, speaks with Dr. Brenda Milner. and the Neuro is at the very foun- dation of this desire and of this recognition for Quebec.” – Jean Charest Premier of Quebec

1 Message from the director

A JEWEL IN THE CROWN We are in the midst of a prosperous and productive period with many exciting developments marked by an outstanding external review, the remarkable David R. Colman, PhD success of our capital In the view of the reviewers, research at As our first good news, the Capital campaign and the festive The Neuro keeps our clinical efforts at Campaign, under the volunteer leader- celebration of The Neuro’s the cutting edge, and our clinical efforts ship of Jacques Bougie and Dominic th 75 anniversary. “A jewel in focus and augment our science. These D’Alessandro, has passed the $38 million McGill’s crown” concluded are indeed gratifying words for those mark with significant gifts toward the a panel of external expert who value the unique integration of North Wing from the J.W. McConnell evaluators in the five-year research and clinical neuroscience that Family Foundation, the Molson review mandated by McGill has characterized The Neuro since its Foundation, the Cyril & Dorothy and University. founding, and I am proud to announce Joel & Jill Reitman Foundation, the that after 75 years, The Neuro is still at Estate of John Gordon, Mr. and Mrs. the very top in terms of global reputation. Paul G. Desmarais, Hugh Hallward, In my view, our international stature is Manulife Financial, Power Corporation, achieved, like our research and clinical the Fondation Jeunesse-Vie and CGI, outcomes, through the dedication and and campaign co-chairs, Jacques Bougie drive of every scientist, clinician, nurse, and Dominic D’Alessandro. The allied health professional, student, staff Neuro-Engineering Program received member and volunteer who commits to founding support from Rio Tinto The Neuro mission. It is to them that I Alcan and the Molson Foundation. extend my thanks and congratulations New fellowships were established for our ongoing accomplishments. thanks to support from National Bank Financial Group, CIBC, Brian Levitt and Claire Gohier, Dr. Brenda Milner, and Dr. Shirley Ferguson Rayport. In addition, generous gifts in support

2 of cutting-edge clinical care and inno- maintain The Neuro tradition of Ethics Committee, has been named vative research programs were received facilitating training and development Director of the McGill Bioethics Unit; from BMO Financial Group, RBC, in neuroscience worldwide, we have and, at the McGill University Health Carolyn and Richard Renaud, Roasters expanded our efforts by hosting clinicians Centre, Alain Ptito is Psychologist-in- Foundation, Scotiabank, The Tenaquip from Cuba and Honduras, and students Chief and Patricia O’Connor is now Foundation and the Reed Family, and from Barbados, China and India, and Director of Nursing & Chief Nursing the R. Howard Webster Foundation. dispatching neuroscientists to Chile Officer at the MUHC. and Brazil. We achieved a new milestone in 2009 To maintain the momentum of growth, when The Neuro Annual Fund led Funds from our Centre of Excellence in we welcomed new faculty members, Commercialization and Research award by volunteers Lorena Cook and Leigh Andrew Reader, an expert in image Taylor generated over $1 million, supported 40 scientific projects and reconstruction and modeling in high allowed us to create 18 new fellowships resolution positron emission tomogra- including $100,000 from our Faculty and studentships. And, to further realize phy (PET); Eliane Kobayashi, an expert and Staff Campaign. Key volunteers the translational value of our research, in epilepsy; and radiopharmaceutical Warren and Joan Chippindale formal- we created a commercialization com- chemist Esther Schirrmacher, who also ized a planned giving initiative with mittee staffed by leaders from industry joined the PET research team in the François Perreten and Marie Carrigan and McGill University. McConnell Brain Imaging Centre. We to facilitate bequests that represent said goodbye and thank you to recent about 16% of the gifts to The Neuro The Neuro is a central component of retirees, Professors Alain Beaudet, year after year. With the help of Jacques the expanded neuroscience program at Mirko Diksic, Christopher Thompson Bougie and Luc Beauregard, we received McGill, where neuroscience is a stra- and Marilyn Jones-Gotman; Marilyn contributions of free media space and tegic priority. The Neuro now houses Kaplow, Administrative Director of advertising time worth over $2.4 million the office of the new McGill Integrated the Neuroscience Mission; and Carol to make our spectacular national pub- Program in Neuroscience (IPN), a Weins, Neuro Librarian. We suffered lic awareness campaign possible. This multi-disciplinary, multi-site graduate the loss of two revered colleagues and strong support for The Neuro, even in program, which increases the visibility friends with the deaths of George a challenging economic environment, of neuroscience at McGill and enhances Karpati and Ernst Meyer. affirms the value of our integrated clinical our ability to recruit the best students and research mission, and speaks to the from around the world. In keeping with Our educational outreach initiatives impact we have on our patients, friends, the growth of neuroscience, Neuro faculty are moving at a fast pace. In partner- members have graduated to senior posi- ship with the National Film Board of staff and the community at large. With tions across campus and across Canada. Canada, we are developing a 3D film two years remaining in our capital cam- Alain Beaudet, former Professor at on the brain. Neuropolis, based on more paign, we continue to implement our The Neuro and past President of the than 80 hours of interviews with experts plans for new programs and new discov- Fonds de la recherche en santé du at The Neuro and elsewhere, uses the eries at The Neuro. Québec (FRSQ), was named President city as a metaphor to reveal the com- Last year, for our 75th anniversary of the Canadian Institutes of Health plex structure and function of the ner- cele­bration, Quebec Premier Jean Research (CIHR). Neuro faculty who vous system. Neuro faculty and students Charest opened our international are pursuing their research programs continue to be engaged with emerg- symposium that featured Nobel while assuming new responsibilities at ing young scientists through Discovery Laureates and other award-winning McGill are Professor Heather Durham Day and Brain Awareness Week. We neuroscientists. as Associate Dean of Graduate and created the NEURO.science.letter, a We hosted a spectacular open house Postdoctoral Studies; Lesley Fellows new e-publication on our research for and our first ever gala, and these events and Alyson Fournier as Co-Directors a general audience, and The Neuro is brought us closer to our former Fellows of the Faculty of Medicine MD/PhD now on Facebook. who trained at The Neuro before estab- program; Josephine Nalbantoglu and lishing prestigious careers around the David Ragsdale co-direct the IPN; world. As part of our commitment to Eugene Bereza, Director of the Neuro’s

3 Michelle Courchesne, Minister of Education, Leisure and Sport and Dr. David Colman at the Time Capsule Ceremony on May 7, 2010. We have also committed to establish NSERC Award of Excellence and the a Neuro-Palliative Care Unit, which prestigious Balzan Prize. The energy of will be the first in North America and these honoured colleagues inspires us all builds on the commitment of Neuro with the drive to achieve as The Neuro staff to provide the highest standard of moves into another new decade. care to patients and their families. This initiative is part of the highly-regarded We welcome you to join us McGill Palliative Care Program, known on this journey. worldwide for training and the delivery “Imagination is  of compassionate care for patients with more important  terminal illness. than knowledge. Some final accolades to colleagues For knowledge is limited  who are very active at The Neuro: to all we now know and  Fred and Eva Andermann were honoured David R. Colman, PhD with an international symposium, the Director understand, while imagination annual Denis Melançon lecture was embraces the entire world,  created in neuroradiology, and Brenda and all there ever will be  Milner was recognized for her pioneering work in cognitive neuroscience with the to know and understand.” Albert Einstein

4 Neuro Advisory Board MINDING OUR FUTURE

Luc Beauregard, CM Lynne Gervais Daniel Dennett, PhD Executive Chairman Associate Vice-President, Director RES PUBLICA Consulting Group Inc. Human Resources Center for Cognitive Studies Jacques Bougie, OC McGill University Austin B. Fletcher Corporate Director Heather Hiscox Professor of Philosophy Co-Chair, The Neuro’s Anchor Tufts University (USA) Thinking Ahead Campaign CBC (Television) News: Morning Vijayalakshmi Ravindranath, PhD Frederick Burbidge, OC Najeeb Khalid Professor and Chairman Former Chairman Chairman & Chief Executive Officer Centre for Neurosciences Canadian Pacific Limited Escher-Grad Technologies Inc. Indian Institute of Science (India) Former Governor, McGill University Richard Levin, MD Louis Siminovitch, CC, PhD, ScD Warren Chippindale, CM, LLD, FCA Vice-Principal (Health Affairs) Director Emeritus Former Chairman & Dean of Medicine Samuel Lunenfeld Research Institute Chief Executive Partner McGill University Mount Sinai Hospital (Canada) Coopers & Lybrand International Philip O’Brien, CM Bernard Zalc, PhD Governor Emeritus, McGill University Senior Advisor Directeur David R. Colman, PhD Telemedia Development Inc. Biologie des Interactions Neurones / Glie Institut national de la santé Director Alex Paterson, OC, OQ, QC et de la recherche médicale (France) Montreal Neurological Institute Senior Partner and Hospital Borden Ladner Gervais LLP Jian-ning Zhang, MD Lorena Cook Former Chairman, Board of Governors Director Sarah Cook Fund of the McGill University Tianjin Neurological Institute Tianjin Medical University Cedars Cancer Institute The Honourable Arthur T. Porter, General Hospital (China) Marvin Corber, CM, FCA P.C., MD Consultant Director General & Chief Neuro Senior Management RSM Richter Executive Officer Martine Alfonso Governor Emeritus, McGill University McGill University Health Centre Administrative Director David M. Culver, CC, OQ, MBA, LLD Dorothy Reitman, CM Neuroscience Mission President The Cyril & Dorothy and Joel & Jill Mark Angle, MD CAI Reitman Family Foundation Associate Director Jacques Daccord Susan Riddell-Fitzpatrick Professional Services Chairman Governor Emeritus Philip Barker, PhD Magnov Inc. McGill University Associate Director Former Chairman, Warren Simpson, FCA Strategic Planning The Ideal Metals Group Chartered Accountant Robert Dunn, PhD A. Jean de Grandpré, CC Benvest Capital Inc. Associate Director Founding Director & Former Governor, McGill University Scientific Affairs Chairman Emeritus L.E. Smith, LLB, QC Lucia Fabijan, BCE Inc. BN Partner Associate Director, Neuroscience Nursing Chancellor Emeritus, Bennett Jones LLP McGill University Thomas Gevas Rima Rozen, PhD Leonard Ellen, LLD Associate Director Vice-Principal (Research & Chief Financial Officer Chairman International Relations) Elizabeth Kofron, Leonard Ellen Canada Inc. McGill University PhD Kappy Flanders Associate Director Meredith Webster Corporate Affairs & Special Projects Co-Chair Board Member Catherine Rowe, Council on Palliative Care R. Howard Webster Foundation CFRE Steering Committee, McGill-Minis Executive Director Governor, McGill University Scientific Advisors External Affairs Abraham Fuks, MDCM Sir John Bell, FRS, PMedSci Donatella Tampieri, MD Professor of Medicine Regius Professor of Medicine Associate Director McGill University University of Oxford (England)

5 Campaign Cabinet 2007-2012 Thinking Ahead

The momentum of The Neuro’s Think­- Leonard Ellen Planned Giving ing Ahead Campaign continues to exceed Chairman Marie Carrigan objectives and this is both a tribute to the Leonard Ellen Canada Co-Founder tremendous efforts of our campaign vol- Najeeb Khalid Omnibus Distribution unteers and the vision of our generous President and Chief Executive Officer Warren Chippindale, CM donors. Escher-Grad Technologies Former Chairman and Chief Richard Renaud Executive Partner Chairman and Chief Executive Officer Coopers & Lybrand International Co-Chairs TNG Corporation Joan Chippindale Jacques Bougie, OC Meredith Webster Lifetime Member Corporate Director Board Member Montreal Children’s Hospital Auxiliary Dominic D’Alessandro, OC R. Howard Webster Foundation François Perreten Former President and Chief Toronto Co-Founder Executive Officer Omnibus Distribution Manulife Financial Camillo di Prata Executive Vice-President and Annual Giving Managing Director, Lorena Cook Head of Corporate and National Neuro Annual Fund Chair Investment Banking Leigh Mackenzie-Taylor National Bank Financial Montreal Chair James Doak Neuro Annual Fund Committee President and Managing Partner Honourary Faculty and Megantic Asset Management Inc. Staff Campaign Co-Chairs L. R. (Red) Wilson, OC Dr. William Feindel, OC Chairman Professor The Wilson Foundation Dr. Brenda Milner, CC Eastern Canada Professor Allison McCain More than 350 elementary school students Former Fellows attended The Neuro’s Time Capsule Ceremony. Chairman Students from The Priory School are pictured McCain Foods Ltd. Dr. Eva Andermann above. Professor Corporations Dr. Frederick Andermann, OC Philip O’Brien, Communications CM Professor Senior Advisor Luc Beauregard, CM Telemedia Development Inc. Executive Chairman Gerry Stefanatos RES PUBLICA Consulting Group Inc. Regional Director and General Manager Major Gifts Hospira Canada Morton Brownstein, CM Foundations Chief Executive Officer Warren Chippindale, Brown’s Shoe Shops Inc. CM Former Chairman and Chief Jean-Guy Desjardins Executive Partner Chairman and Chief Executive Officer Coopers & Lybrand International DJM Capital Inc. A. Jean de Grandpré, CC Director Emeritus BCE Inc.

6 Raising The Neuro’s profilE

In May 2008, The Neuro embarked on a campaign to raise public aware- ness of our outstanding work and the importance of neuroscience in our lives. Since then, close to $3 million worth of free TV, print and outdoor advertisements have been seen in Montreal and across the country. Our thanks to Astral Media for launching this initiative with $2.3 million in donated advertising space. In addition, we recognize and thank St. Joseph Communications, Mediacity and Lumibus, along with CGCOM, our Montreal communications agency, all of whom are partners with us on this initiative. External Affairs Steering Committee Under the leadership of Luc Beauregard, the External Affairs Steering Committee works with The Neuro’s Office of External Affairs to maximize opportunities to raise The Neuro’s profile within the Quebec population. Roberto Bellini President and Chief Executive Officer BELLUS Health Inc. Alan Desnoyers District Vice President Montreal Downtown BMO Financial Group Danièle Dufour Director, Corporate Communications McKesson Canada Andrew Molson Vice-Chairman, Legal Affairs and Corporate Secretary RES PUBLICA Consulting Group Inc. Jennifer Pevec Community Volunteer Sylvie Roy Vice-President, Corporate Marketing and Communications National Bank Financial Group

7 Faculty OUR WORLD-CLASS THINKERS

Stellar Scholars, Dedicated Physicians, Leading the Pathways of Discovery

Emeritus Professors Stefano Stifani, PhD Theodore Kolivakis, MD Donald Baxter, OC, MD* Donatella Tampieri, MD Neda Ladbon-Bernasconi, MD, PhD Gilles Bertrand, OC, MD* Robert Zatorre, PhD Marcelo Lannes, MD Roméo Éthier, MD* Associate Professors Gabriel Leonard, PhD Diane Lowden, RN, MSc(A), MSCN William Feindel, OC, GOQ, MDCM, D.Phil. Michel Aubé, MD Mohammad Maleki, MD Hanna Pappius, PhD* Amit Bar-Or, MD Judith Marcoux, MD Alan Sherwin, MD, PhD* Andrea Bernasconi, MD Ernst Meyer, PhD4 John Stewart, MD* Daniel Chartrand, MD Thierry Muanza, MD Christopher Thompson, ScD* Jean-François Cloutier, PhD Patricia O’Connor, RN, MSc(A), CHE Professors Louis Collins, PhD Christopher Pack, PhD Eva Andermann, MD, PhD Alain Dagher, MD Liliana Pedraza, PhD Frederick Andermann, OC, MD François Dubeau, MD Kevin Petrecca, MD, PhD Jack Antel, MD Lesley Fellows, MD, PhD Bobbi Popovec, MD Douglas Arnold, MD Edward Fon, MD Deborah Radcliffe-Branch, PhD Massimo Avoli, MD, PhD Alyson Fournier, PhD Jean-Pierre Roy, MD Philip Barker, PhD Line Jacques, MD Edward Ruthazer, PhD Alain Beaudet, MD, PhD*1 Petr Kavan, MD Frederick Salevsky, MD David Colman, PhD Timothy Kennedy, PhD Esther Schirrmacher, PhD Rolando Del Maestro, MD, PhD Yves Lapierre, MD Amir Shmuel, PhD Mirko Diksic, PhD* Denis Melançon, MD David Sinclair, MD Robert Dunn, PhD Josephine Nalbantoglu, PhD Denis Sirhan, MD Heather Durham, PhD2 David Ragsdale, PhD Jean-Paul Soucy, MD Alan Evans, PhD Andrew Reader, PhD Thomas Stroh, PhD Jean Gotman, PhD Ghislaine Savard, MD Viviane Sziklas, PhD Daniel Guitton, PhD Ralf Schirrmacher, PhD Martin Veilleux, MD Edith Hamel, PhD Jeanne Teitelbaum, MD Kenneth Hastings, PhD Daria Trojan, MD Lecturers Paul Holland, PhD Ivan Woods, MD Samson Antel, PhD Barbara Jones, PhD Assistant Professors Diane Diorio, MD Maria Hamakiotis, RN, MSc(A) Marilyn Jones-Gotman, PhD* Mark Angle, MD 3 Sridar Narayanan, PhD George Karpati, OC, CQ, MD Barry Bedell, MD, PhD Claire Nehme, RN, MScN Richard Leblanc, MD Tania Bruno, MD Rosa Sourial, RN, MSc(A) Peter McPherson, PhD Maria Del Pilar Cortes Nino, MD Walter Vanast, MD, PhD Brenda Milner, CC, GOQ, ScD, PhD Jelena Djordjevic, PhD André Olivier, MD, PhD Liam Durcan, MD 1 President & Chief Executive Officer, Michael Petrides, PhD Lucia Fabijan, BN, MSc(A) Canadian Institutes of Health Research Bruce Pike, PhD Steven Frey, PhD 2 Associate Dean of Graduate Gilles Plourde, MD Daniel Gendron, MD and Postdoctoral Studies Alain Ptito, PhD Angela Genge, MD 3 Deceased February 6, 2009 John Richardson, MD, PhD Benoît Goulet, MD 4 Deceased February 5, 2010 Richard Riopelle, MD Christophe Grova, PhD * Retired Abbas Sadikot, MD, PhD Marie-Christine Guiot, MD Philippe Séguéla, PhD Jeffery Hall, MD Eric Shoubridge, PhD Denise Klein-Broomberg, PhD Wayne Sossin, PhD Eliane Kobayashi, MD, PhD

8 New Faculty at The Neuro ADDED BRAINPOWER

The Neuro’s ultra-specialized scientists and clinicians are recruited from all over the globe for their unmatched expertise; their work covers a broad spectrum of neuroscience, creating one of the most diverse and innovative research and clinical environments in the world. Eliane Kobayashi is a neurologist with Tomography (PET), which is a power- Ms. Alfonso takes over from Marilyn expertise in the field of Epilepsy. A ful imaging technique used in oncology, Kaplow, who retired in 2009. In native of Brazil, Dr. Kobayashi com- neurology and cardiology with emerging addition to her role at The Neuro, pleted her medical and doctoral training applications in molecular imaging. Ms. Kaplow also served as Director of at the Campinas State University. She Esther Schirrmacher, a distinguished Quality Management, MUHC. She conducted post-doctoral research at The radiochemist trained at the University made a career from her commitment Neuro and was appointed an Assistant of Tübingen, Germany, joined The to quality and compassionate care for Professor in 2007. Dr. Kobayashi has Neuro as an Assistant Professor in the patients. We thank her for her indefati- received numerous awards including the McConnell Brain Imaging Centre. gable championship of The Neuro. Early Career Physician-Scientist Award Dr. Schirrmacher, formerly at the Lady New role for Lucia Fabijan from the American Epilepsy Society. Davis Research Institute, does radio- Her research at The Neuro focuses on In 2010, Lucia Fabijan was named pharmaceutical research and studies Associate Director of Nursing for the the application of multimodal neuro- neuroendocrine tumours. physiology and imaging (EEG, MEG, Neuroscience Mission, which has ser- EEG-fMRI and MRI) in the diagnosis New Leadership for the vices at The Neuro and the Montreal Neuroscience mission and understanding of epilepsy. General Hospital. Before taking on this Martine Alfonso joined The Neuro in new role, Ms. Fabijan held key leadership Andrew Reader joined The Neuro’s April 2009 as the new Administrative positions in the Neuroscience Mission as brain imaging group as an Associate Director of the MUHC’s Neuroscience Coordinator of Nursing Education and Professor in the Department of mission. Ms. Alfonso is responsible for Coordinator of Ambulatory Services, and Neurology and Neurosurgery. A native the administration of clinical activities at was instrumental in developing outstand- of the UK, Dr. Reader was Senior The Neuro, neuroscience activities at the ing advanced practice nursing roles and Lecturer in the Faculty of Engineering Montreal General Hospital and related strong inter-professional clinical teams and Physical Sciences at the University of ambulatory services. In her previous to support patients living with chronic Manchester where he had worked since position at the Institut de réadaptation neurologic disorders. Ms. Fabijan, who 1999. He earned a BSc in Physics and de Montréal, she was head of the Stroke has a BN from the University of Calgary Computational Physics at the University Program and co-led the Montreal Stroke and an MSc from McGill. She worked at of Kent in Canterbury, and a PhD in Network, an MUHC initiative, with Dr. the Montreal Children’s, Royal Victoria, Medical Physics at the University of Richard Riopelle. Ms. Alfonso has a BSc and Jewish General hospitals earlier in London. Dr. Reader conducts research in Physical Therapy from McGill and a her career. on image reconstruction, data correc- Masters of Business and Organizational tion, system and kinetic modeling with Ms. Fabijan takes over from Patricia Development from Université Laval. high resolution 4D Positron Emission O’Connor who was recently named Director of Nursing and Chief Nursing Officer of the MUHC. Ms. O’Connor was Associate Director of Nursing (Neuroscience) at The Neuro from 1990 to 2009 and was recently honoured with a Lifetime Achievement Award. She remains a visible role model, actively supporting nurses in their own profes- sional development and lobbying for resources to enable exemplary nursing care. We thank Ms. O’Connor for her strong belief in the incomparable value of nursing to patient and family care and her enduring legacy at The Neuro. Eliane Kobayashi Andrew Reader Esther Schirrmacher

9 Faculty Awards and Distinctions GREAT MINDS GREAT ACHIEVEMENTS

Inspiring achievement at The Neuro. Killam Scholars Endowed Chairs The exceptional quality of our faculty (2007–2012) David Colman, Wilder Penfield Chair and staff creates a vibrant environment for Amit Bar-Or in Neurosciences research, clinical and teaching activities. Barry Bedell Rolando Del Maestro, William Feindel Many honours and awards have been Andrea Bernasconi Chair in Neuro-Oncology bestowed on our faculty and staff in Jean-François Cloutier George Karpati*, Izaac Walton Killam recognition of their outstanding work. Chair in Neurology Lesley Fellows Below are some highlights. Brenda Milner, Dorothy J. Killam Edward Fon Professor in Neuropsychology Alyson Fournier June 1, 2006 – September 1, 2010 André Olivier, W.V. Cone Chair Angela Genge in Neurosurgery Canadian Institutes Timothy Kennedy of Health Research Bruce Pike, Killam Professor Senior Investigator Christopher Pack Alan Evans Edward Ruthazer Order of Canada Eric Shoubridge Michael Sinnreich Frederick Andermann, OC Robert Zatorre Robert Zatorre Donald Baxter, OC Investigator Canada Research Chairs Gilles Bertrand, OC Philip Barker Jean-François Cloutier William Feindel, OC Alain Dagher David Colman George Karpati, OC* Peter McPherson Alyson Fournier Brenda Milner, CC Bruce Pike Christopher Pack Order of Québec Wayne Sossin Andrew Reader William Feindel, GOQ Clinician Scientist Edward Ruthazer George Karpati, CQ* Lesley Fellows Ralf Schirrmacher Brenda Milner, GOQ Edward Fon Amir Shmuel Royal Society of Canada Fonds de la recherche McGill University Chairs Daniel Guitton en santé du Québec James McGill Professors Barbara Jones Chercheurs nationaux Douglas Arnold George Karpati* Philip Barker Alan Evans Brenda Milner Timothy Kennedy Peter McPherson Eric Shoubridge Bruce Pike Michael Petrides National Academy Wayne Sossin Bruce Pike of Sciences (USA) Stefano Stifani Eric Shoubridge Brenda Milner (Foreign Associate) Chercheurs boursiers Wayne Sossin American Academy Andrea Bernasconi Stefano Stifani of Arts and Science Louis Collins Robert Zatorre Brenda Milner Alain Dagher William Dawson Scholars Michael Petrides Edward Fon Philip Barker Canadian Medical Hall Christophe Grova Amit Bar-Or of Fame Timothy Kennedy William Feindel Eliane Kobayashi Herbert Jasper Neda Ladbon-Bernasconi Brenda Milner Peter McPherson Wilder Penfield Abbas Sadikot Michael Sinnreich * Deceased

10 AWARDS Foundation of Stars 2009 Young Investigator Award for Lifetime Achievement Awards International Balzan Foundation Child Health Research Balzan Prize Michel Aubé, MD Amit Bar-Or (2009) Associate Professor, McGill University Brenda Milner (2009) Commonwealth Fund Neurologist, The Neuro The IEEE, Nuclear and Plasma Harkness Associate in Health Christopher Thompson, ScD Sciences Society and Nuclear Care Policy and Research Professor, McGill University Medical and Imaging Sciences Council Edward J. Hoffman Patricia O’Connor (2008) Scientist, The Neuro Medical Imaging Scientist McGill University The Killam Trust Award Faculty of Medicine Trustees – Mr. George Cooper, Christopher Thompson (2008) John and Clara Fraser Mr. John Matthews, Mrs. Ann McCaig Memorial Award and Mr. John S. Montalbano Alfred P. Sloan Foundation Research Fellowship (USA) Thomas Stroh (2008) Established Investigator Award Eric Shoubridge, PhD Christopher Pack (2006-2009) MUHC Director General’s Award Professor, McGill University NARSAD, The World’s Leading Scientist, The Neuro Charity Dedicated to Mental Mark Angle (2009) Health Research Outstanding Team Award Goldman-Rakic Prize Neuro Convocation & Neuro-Intensive Care Unit Team Brenda Milner (2009) Lifetime Achievement 2008 Awards Lifetime Achievement Awards NARSAD, The World’s Leading Charity Dedicated to Mental Celebrating an outstanding community of Denis Melançon MD Health Research faculty, staff, philanthropists and volunteers. Associate Professor, McGill University Young Investigator Award Neuroradiologist, The Neuro 2010 George Karpati, Christopher Pack (2008) Lifetime Achievement Awards OC, CQ, MD* Professor, McGill University Society of Experimental Eva Andermann, MD, PhD Isaac Walton Killam Chair Psychologists Professor, McGill University Norman A. Anderson Lifetime in Neurology Achievement Award Neurogeneticist, The Neuro Neurologist, The Neuro Ernst Meyer, PhD* Brenda Milner (2010) The Cyril & Dorothy and Joel & Assistant Professor, McGill University Jill Reitman Family Sleep Research Society Scientist and Radiation Safety Officer Distinguished Scientist Award The Neuro Promising Young Investigator Award Lesley Fellows Barbara Jones (2009) MDCM, D.Phil. Patricia O’Connor, RN, MSc(A), CHE Assistant Professor, McGill University Multiple Sclerosis Society Director of Nursing & Chief Neurologist, The Neuro of Canada Nursing Officer Don Paty Career McGill University Health Centre Outstanding Team Award Neuro-Oncology Team Development Award The J.W. McConnell Family Amit Bar-Or (2007, 2008) Foundation * Deceased Natural Sciences and Mid-Career Achievement Award Engineering Research Council Peter S. McPherson, PhD of Canada (NSERC) Professor, McGill University Award of Excellence Scientist, The Neuro Brenda Milner (2009, 2010) Outstanding Team Awards Order of Québec Animal Care Facility Team Grand Officer Preston Robb Neurological Day Brenda Milner (2009) Centre Team Québec Association of Neurologists Prix Reconnaissance Michel Aubé (2009)

11 12 Nurses Neuroscience Nursing Awards of Excellence are awarded each OUR NERVE year during National Nursing. Week in May to nurses working at The Neuro and the Montreal General Hospital. CENTRE These peer nominated awards are given to underscore the important work done by the nursing staff. Nurses at The Neuro are on the front Award for Excellence line and are involved in all aspects of the in Leadership health care system, whether it is research, Claire Nehme (2010) Rosa Sourial (2009) administration, education or clinical care. Maria Hamakiotis (2008) Their role in improving the health and  Yasmin Khalili (2008) well-being of others is critical. Awards for Excellence in Nursing Practice Suzanne Do-Davoll (2010) Transforming Care at the Bedside Rocio Del Buey (2010) Neuroscience Nurses at The Neuro are the first in Canada to participate in Helen Fong (2009) the international program Transforming Care at the Bedside (TCAB). This Melissa Phenix (2009) program, created by the Robert Wood Johnson Foundation and the Institute for Healthcare Improvement (IHI), was designed to turn a select set of high- Josée Beloin (2008) performing hospitals into innovative learning labs for real-time improvement Award for Excellence in patient care. The nurses are working to define and implement best practices in Nursing Education in patient-centered inpatient care, and to increase direct care time for nurses. Elizabeth Murphy-Lavallée (2009) American and European hospitals that have participated in TCAB report better Operating Room Team (2008) clinical outcomes, reduced nurse turnover and lower costs. Nurses will apply Intensive Care Unit Team (2008) their energy and expertise, and involve inter-professional team members, patients Award for Excellence and their families to transform patient care. for Partner-in-Practice Patricia McAslan (2010) Debbie Bhoop (2010) Jaime Valera (2009) Catia Abreu (2008) Louise Desaulniers (2008) Award for Nursing Research Diane Lowden (2010) Lucy Wardell (2008) Valerie Shannon MUHC Award for Innovative Leadership Patricia O’Connor (2008) Friends of the Neuro Bursaries for studies at the B.Sc., M.Sc. or PhD levels Lisa Goulet (2008) Nancy Ouellet (2008) Kitty Toye (2008) Wanda Montes Bursary Josée Lizotte (2008)

Mrs. Grazia Anobile, recovering from back surgery at The Neuro, with nurse Annik Plamondon.

13 CECR Award BRAINWAVES

In 2007, the Montreal Neurological Institute of McGill University was named one of seven Centres of Excellence in Commercialization and Research (CECR) in recognition of our 75 year history of accomplishment in innovative neuroscience research. Our goal in accepting this honour was to establish the best CECR program in the country. Under the auspices of the CECR Award, we have expanded our most innovative and high risk fundamental science exploration, as well as focused on programs that commercial- ize basic research discoveries and move treatments from the bench into the clinic. Our CECR funding has led to the development of novel devices and diagnostics certain to benefit the health of all Canadians. Trailblazing advances in neuroscience and patient care are at the heart of what we do at The Neuro. The CECR Award has allowed us to catapult our most interesting, high-risk programs to the forefront of our efforts. Some of these programs are highlighted here.

1

Building a Better Roadmap Each year, hundreds of Canadians requiring neuro­ surgery end up at the Montreal Neurological Hospital. These patients require resection of lesions that are extremely close to functional areas of the brain critical to movement, vision, sensation or language. Their condition often will have been deemed inoperable due to the location of the lesion. Dr. Denise Klein is aggregating the powerful laboratory imaging techniques available throughout The Neuro and planning to deliver a real-time, integrated output in the operating room. 1 2

14 If It’s There, 3 We’ll Find It Roughly one-third of epi- lepsy patients suffer seizures that do not respond to drug treatments. Uncontrolled epilepsy has devastating socio-economic consequences, is harmful to the brain and is associated with higher mortality. Dr. Andrea Bernasconi is giving new hope to epilepsy patients with computer modeling to reveal previously unseen targets for surgery. 2

Tracking Proteins Getting Back Your Making the Best Tapping, 1, 2, 3, 4. Understanding the cellular Nerves Impression Rapid tapping with a stylus on basis of disease is one of the The Central Nervous System When The Neuro first a metal plate is a test often revolutionary developments (CNS) consists of the brain opened its doors 75 years used to evaluate motor in neurological research. and spinal cord. It controls ago, much of the discovery speed and coordination Today it is understood that our thoughts, senses and in medical science was in patients with a neuro­ schizophrenia, Parkinson’s, movement through an incred- accomplished through post- logical disease such as MS, ALS and many others ibly complex system in mortem examination. Today, Multiple Sclerosis. Many are diseases of the cells that which nerve cells connect the most sophisticated years ago, a research team underlie all brain functions. to each other to transmit pathologies are identified at The Neuro led by Dr. Dr. Peter McPherson and and receive information. and studied in vivo through Gabriel Leonard demonstrat- his team have come up with Dr. Alyson Fournier is edg- the extraordinary power of ed that rapid repetitive tap- a hybrid method of making ing closer to the holy grail medical imaging and measur- ping with one hand is mainly antibodies that is faster, of spinal cord injury treatment ing equipment. Scientists sensitive to primary motor simpler and economical. – getting the severed nerves at The Neuro’s McConnell brain areas and the corre- With built-in validation to re-establish functional Brain Imaging Centre have a sponding motor pathways. from the experience of connections. The road ahead long history of developing Dr. Leonard is putting a Neuro researchers, a cata- is long, but the rewards con- novel methodology and new twist on established logue of products is being siderable. translating them into routine technology to produce a assembled for research and research clinical use or com- superior device for testing commercial utilization. mercializing them. These motor skills in patients with 3 include innovative PET scan- neuromuscular or neurologi- ners, neurosurgery planning cal disease. The prototype is software and computerized testing well and commercial imaging analysis tools. development is anticipated in 2010-2011.

15 Sharing Insights Worldwide MINDS OVER MATTER

Global thinking is second nature at The Wilder Penfield Lecture Francis L. McNaughton Neuro. Every year, some of the best 2009 Lecture scientists from around the world as Professor Sir John Bell 2009 well as members of the government University of Oxford, Oxford, UK Guy Rouleau, MD, PhD and business communities gather here 2008 Université de Montréal, Montréal, QC to share ideas, research and knowledge The Honourable Jim Prentice 2008 as part of our prestigious named lecture Minister of Industry Katherine Bushby, MD series or our weekly Killam Lecture Government of Canada Institute of Human Genetics Newcastle University Series supported by the Killam Trust. Ottawa, ON Newcastle upon Tyne, UK Dorothy J. Killam Lecture 2007 2008 Thomas Rando, MD, PhD Alicia Soderberg, PhD Stanford University School of Princeton University Medicine, Stanford, CA USA Princeton, NJ USA Theodore Rasmussen Lecture William Feindel Lecture 2008 2010 M. Gazi Yasargil, MD G. Rees Cosgrove, MD University of Arkansas Brown University for Medical Sciences Rhode Island Hospitals Little Rock, AR USA Providence, RI USA 2009 Herbert Jasper Lecture Isabelle Germano, MD 2008 Mount Sinai School of Medicine Paul W. Glimcher, PhD New York, NY USA New York University 2008 New York, NY USA Ricardo S. Centeno, MD University of Sao Paulo Sao Paulo, Brazil

16 Global connections – Neuro researchers and physicians have forged collaborations and partnerships with nations around the world.

Donald W. Baxter Lecture W.V. Cone Lecture 2008 2010 2009 Giuseppe Scotti, MD Frances Jensen, MD J. Max Findlay, MD, PhD Free University Vita Salute Harvard Medical School University of Alberta, Edmonton, AB San Raffaele Boston, MA USA 2007 Milan, Italy 2009 Paolo Cappabianca, MD Jerzy Olszewski Lecture Michael Aminoff, MD, DSc University of Naples, Naples, Italy 2010 University of California Brenda Milner Lecture in Karel Svoboda, PhD San Francisco, CA USA Cognitive Neuroscience Howard Hughes Medical Institute 2008 2010 Janelia Farm Research Campus Donald Calne, MD John O’Keefe, PhD, FRS Ashburn, VA USA University of British Columbia University College London Vancouver, BC London, UK 2007 2009 John Noseworthy, MD Mortimer Mishkin, PhD Mayo Clinic College US National Institutes of Medicine of Mental Health Rochester, MN USA Bethesda, MD USA KAC Elliott Lecture 2008 2009 Stanislas Dehaene, PhD Rémi Quirion, PhD Collège de France, Saclay, France Douglas Hospital Research Centre Denis Melançon Lecture McGill University Montreal, QC 2009 Karel Terbrugge, MD University of Toronto, Toronto, ON

17 Patient Services BETTER LIVES AHEAD

Quality Clinical Care: our Priority

The Neuro is a highly-specialized aca- Empowering our patients Parkinson’s treatment at demic medical centre where patients are The Neuro: an unwavering The Neuro was the first to introduce the focus to triumph cared for using the most advanced tech- Toolbox Program to Quebec thanks to nology and treatments, such as Canada’s support from our dedicated donors and The Parkinson’s Clinic at The Neuro, first 640 resolution 320-slice CT scanner the belief that this program should be an serves patients with Parkinson’s disease or an O-arm Imaging system. Almost integral part of a patient’s health man- and a variety of other movement dis- 50% of Canadians, or 15 million peo- agement plan. The goal of the Toolbox orders. The Clinic has been expanding ple, will experience the devastation of a Program, a chronic disease self-management and improving its services with the help neurological disorder and many will be program, is to address how to best sup- of funding from the Parkinson Society hospitalized. At The Neuro, we strive port patients with chronic illnesses and Canada, which includes a special pro- to give our patients the exceptional care their families and to empower them to gram that addresses the needs of the that they deserve in the face of daunting become informed and active participants young onset, newly diagnosed popula- diseases. Each member of our diverse, in their care. Teaching patients to self- tion. The Neuro has been designated a all-encompassing health care team is manage their illness improves function- National Parkinson Foundation (USA) fully committed to The Neuro’s mission ing and reduces pain and healthcare Center of Excellence. of advancing research, education and costs. The Parkinson’s Clinic at The Neuro patient care. brings together a multidisciplinary team of neurologists, clinical nurse specialists, “As a participant in the six week physiotherapists, occupational therapists, My Toolbox course, I benefited speech therapists and social workers. greatly from the information and support given by the excellent Parkinson’s patients also participate in trained volunteers who led the ongoing clinical studies. workshops. Equally remarkable was the interaction among group members. Strangers exchanged “I have been a Parkinson’s information and became friends, patient at The Neuro’s Movement supporters and allies against the Disorder Clinic since November ravages of chronic illness. I wish 2007. more patients with chronic illnesses and their physicians were aware I believe that the team concept of this important adjunct to in caring for the patient is a very traditional medical care.” positive approach. There are often – Nancy Turner activities and meetings to further increase the knowledge of the patient. I feel that I am receiving the best treatment and hopefully one day there will be a cure for Parkinson’s.” – Barbara Finkelstein Stein

18 Yves Ferland with sons, Samuel and Étienne

The Neuro’s pain clinic: Improving treatment options providing hope of patients living with brain “Sometimes life can take an tumours The Neuro is a leader in the treatment unexpected turn, and that’s what of chronic pain, a condition that leads Since the grand opening of the Brain happened to me. I hit my head to decreased function and reduced qual- Tumour Research Centre in 2002, we while skiing and went for a routine have treated thousands of patients in our test at The Neuro to ensure that ity of life. Pain management is gaining everything was in order. And greater attention partly because, as the neurosurgerical operating rooms and in that’s when they discovered a population ages, pain syndromes are the brain tumour clinic, and we have brain tumour, which was about simply more prevalent. recruited several new scientists and clini- the size of a ping-pong ball. cians to the Centre. Naturally, I was in total shock. Our Pain Clinic specializes in the treat- In that dark moment where my ment of neuropathic pain, or pain that Together, this outstanding team has mortality seemed inevitable, generally occurs from an injury to a conducted clinical trials to test the effi- Dr. Hall, my surgeon, helped me nerve. It is estimated that over 2.2 million cacy of novel pharmacological agents in cope with this dramatic news and preventing brain tumour recurrence. ensure my family that my chances Canadians suffer from neuropathic pain, of recovery were excellent. He the symptoms of which include tingling, They have made hundreds of new dis- recognized the absolute urgency numbness and shooting or burning sen- coveries and have disseminated this new for me to go into surgery, and one sations. Patients receive the best care knowledge in the form of first-rate pub- week later I was on the operating from our outstanding team of surgeons lications in the world’s major scientific table. I feel very lucky that the journals. tumour was caught on time. I feel and clinicians. The ultimate goal is to even luckier that The Neuro was help improve a patient’s quality of life by The more we learn, the better the therapies there for me. Now I am giving more effectively treating the underlying we can develop. back – both as a donor and as etiology for their pain. a volunteer.” – Yves Ferland

19 Thinking Ahead The power of philanthropy

The power of philanthropy has been transformational SUPPORTING THE NEURO’S WORK for The Neuro’s development over the past 75 years. Private support has helped The Neuro The philanthropic vision and generosity of our donors maintain its extraordinary quality in has enabled The Neuro to remain at the very forefront of basic research, expand its outstanding health research and patient care for over 7 decades. translational research and continue its exceptional care of patients. Only Thank you for making a difference! through investing in the up and coming generation of brain science visionaries and giving them the tools to move their science forward, can we identify new, promising therapies and strategies in the laboratory and ensure that they are brought quickly to the patients who need them.

20 NORTH WING EXPANSION: INNOVATIVE PROGRAMS: Thanks to a contribution of $2 million INTEGRATING CLINICAL CARE TRANSFORMING NEUROSCIENCE from The Molson Foundation to sup- AND NEUROSCIENCE RESEARCH Neuroscience is picking up speed – and Since its founding, Neuro researchers and port the education and training of gradu- support for Innovative Programs guar- ate students and post-doctoral fellows physicians have worked hand in hand to antees us the flexibility to be there with better understand the healthy nervous who will be recruited as a part of this solutions when new questions emerge. program, the future is promising. We system, and to uncover the mechanisms These ideas, still in the formulation stage, of diseases that afflict it. Through their are one step closer to figuring out how will give us the opportunity to expand to rebuild an injured nervous system or close collaboration, problems encoun- our research into new directions that we tered in the clinic inspire research, and to make a human interface completely can’t even imagine now – exploring and with machines. new findings from the labs are directly bringing together new disciplines and applied to meet patients’ medical needs. technologies that we hope will improve Transforming ALS Research and Patient Facilities The North Wing Pavilion expansion the quality of life for those debilitated by Thanks to a $2 million donation from will continue this tradition, adding eight injury or neurological disease. floors of much-needed space for inte- the Tenaquip Foundation and the Reed NEUROENGINEERING: HUMANS Family, The Neuro will soon be home grated research and clinical neuroscience INTERFACING WITH MACHINES that will help ensure the continued long- to the new Reed Family Motor Neuron Our Neuro faculty have joined forces term growth and impact of The Neuro. Disease Research Unit named in hon- with engineers, biologists, physicists, and our of Ken Reed, the Company’s late We recognize the J.W. McConnell computer scientists at McGill University founder and president, who passed away Family Foundation, the Molson to build a NeuroEngineering Program from ALS. By investing time and effort Foundation, the Cyril & Dorothy – the melding of nanotechnology, engi- into understanding its causes, we look and Joel & Jill Reitman Foundation, neering, and neuroscience. Together, forward to improving both early diag- the Estate of John Gordon, Mr. they are addressing compelling medical nosis and treatment options to those and Mrs. Paul G. Desmarais, Hugh problems such as spinal cord injury, limb affected by this disease. Hallward, Manulife Financial, Power amputation and sensory or motor deficits Corporation of Canada, the Fondation associated with neurological disorders. Jeunesse-Vie and CGI, and campaign The entire team is devising biological co-chairs, Jacques Bougie and Dominic platforms and engineering tools geared D’Alessandro, whose leadership contri- to restoring function and repairing the butions are helping to make the North nervous system. Wing Pavilion a reality. To kick start the NeuroEngineering Program, Rio Tinto Alcan committed $1 million to the program. “Good health and strong healthcare facilities are key to a community’s success and growth. Supporting The Neuro’s innovative NeuroEngineering Program is another way that we can play a role in improving the quality of life of people in Quebec and around the world.” – Richard Evans, former Chief Executive, Rio Tinto Alcan

21 Fellowships: National Bank Financial Group’s attracting the best and brightest young minds $500,000 donation to create the National Brain tumour research at The Neuro has Bank Post-Doctoral Fellowship in been given a boost thanks to the efforts Experimental Therapeutics will allow of Claire Gohier and Brian Levitt who The Neuro to recruit some of the world’s have raised over $1 million to create a brightest and most highly motivated new Post-Doctoral Neuro-Oncology scientists to proceed at full speed with Research Fellowship. It will offer post- careers in academic medicine. The first doctoral fellows the opportunity to work fellowship, awarded to Dr. Isabelle with so many of the superb teachers and Thiffault, will fund a revolutionary stem mentors currently at The Neuro and will cell research project that will advance attract and train qualified researchers not only our basic understanding of the with the goal of treating patients with mechanisms of neurological disorders but brain tumours more effectively. also aid the development of new therapies for diseases such as ataxia, Alzheimer’s, Tony Proudfoot, a veteran of the CFL, and Parkinson’s. played for the Montreal Alouettes from 1971 to 1979. He is the author of “First and Goal!” and for the past 30 years, he has been a physical education professor at Dawson College, as well as a sports commentator for CJAD. On June 28, 2007, after announcing publically that he had been diagnosed with Amyotrophic Lateral Sclerosis, he and his family created The Tony Proudfoot Fund, in partnership with the ALS Society of Quebec. Inspired by his great strength and determination, his many fans and admirers have combined their energy and resources to support Tony and his family in this important initiative to raise awareness and funds for ALS. Donations from The Tony Proudfoot Fund support postdoctoral fellowships and research into the causes From left to right: Joan Chippindale, Warren Chippindale, Marie Carrigan and François Perreten. of and treatments for ALS.

Planned Giving: In 2008, Neuro Planned Giving Co-Chairs Joan and Warren Chippindale welcomed two new co-chairs to their Committee – François Perreten, a patient at The Neuro and his wife, Marie Carrigan. Together their objective is to raise awareness and educate people about the importance of planned gifts such as bequests and gift annuities that enable donors to match tax benefits and estate planning with their philanthropic goals.

Isabelle Thiffault

22 23 24 THE NEURO ANNUAL FUND SURPASSING THE $1 MILLION MILESTONE

Support for the Annual Fund is not just important, it is critical. These annual funds are directed toward the Creating Hope most immediate needs of The Neuro The Neuro Annual Fund is fortunate and allow us to take advantage of some to be able to count on groups of energetic, of the most promising opportunities dedicated and generous people who support that arise during the course of the year. its activities by organizing events and/or Importantly, this fund helps leverage establishing funds in honour or in memory other donations. The Neuro’s Annual of loved ones who have been touched by Fund continues to break records, this neurological diseases. year surpassing the $1 million mark for the first time. We wish to recognize and thank: • The Bolger family and the B-Strong Fund A huge part of this success is The • Anna Colaninno and the Tony Colaninno Neuro’s annual Faculty and Staff Fund supporters Campaign. Each year, more than • Lina Di Giovanni and the friends of 75 volunteer leaders and hundreds of the Franco Di Giovanni Foundation supporters become involved and show • L’association épilepsie Abitibi-Témiscamingue their support for the important work • La Fondation Debbie Murray pour la SLA being undertaken by their colleagues. In the past four years, faculty and staff • Mrs. Beverley Fields for her MS Research have donated close to $400,000. appeal • David Adler Memorial Fund Since the launch of The Neuro’s • Gertrude and François Beauregard Fund Thinking Ahead Campaign, the Annual • Beatrice Cohen-Pinchuk Memorial Fund Fund has contributed $5.6 million • Leslie Davidson Fund – or 15% – toward the $38 million campaign total. • Issie Engel Fund • Peter Kermack Fund The Neuro Annual Fund • Topor Family Fund Committee • Weiss Family Fund for ALS Research The Neuro Annual Fund Committee is responsible for securing annual and recurring support for The Neuro. Each donation brings us one step closer to finding better, more effective treat- ments for neurological disorders. Lorena Cook, National Chair Leigh Mackenzie Taylor, Montreal Chair Gina Di Girolamo Franca Monti Colleen Wicha Angelo Parziale

Elementary school students visit The Neuro each year during Brain Awareness Week in March.

25 COMPASSION WHAT IT TAKES TO GIVE

Thank you, donors. Jewish Community Foundation Bennett Jones LLP Talecris Biotherapeutics of Montreal Thank you to all of you Carl Zeiss Canada Limited Tascott Services Incorporated John F Kennedy High School CGI Temple Aysgarth Investments who have contributed and K.K. Charity Foundation Charles River Laboratories Preclinical Incorporated will continue to contribute Fondation J.-Louis Lévesque Services Teva Neurosciences and for believing so strongly Gustav Levinschi Foundation CIBC R.A. Utting Associates Incorporated in the future of The Neuro. Vincent Massey Collegiate David Forest Financial Services Walker Glass Company Limited Your conviction and donations The J.W. McConnell Family individuals Foundation Deans Knight Capital Management make all the difference. The Brenda Milner Foundation Limited Sawsan Abdulwahab The Molson Foundation Delsan Dr. Mounir N. Abou-Madi June 1, 2007 – Fondation Famille A. Pizzagalli Decasult Incorporated Norah Almanqour May 31, 2009 The Cyril & Dorothy and Joel & Jill Caisse Populaire Desjardins Dr. Eva & Dr. Frederick Andermann Donors who have made Reitman Family Foundation Canadienne Italienne Janet & Marcus Arts Dessau-Soprin Incorporated an annual contribution of The Sam & Jennie Rovit Memorial J. Brian Aune Foundation FLS Transportation $1,000 or more and for Dr. Massimo Avoli Order of Saint Lazarus of Jerusalem Gamma Rental Incorporated Cynthia Baxter in Canada whom we have received Genivar Incorporated Anne Bieler Baxter & Dr. Donald express permission to publish The Seymour Schulich Foundation Gillespie-Munro Incorporated W. Baxter their names. ALS Society of Quebec and the Tony Great-West Life, London Life Michelle & Luc Beauregard Proudfoot Fund and Canada Life Dr. Gilles Bertrand Alvin Segal Family Foundation Hai Vision Systems Incorporated Maryse D. Bertrand The Armagh L. Sifton Charitable Foundations and Hospira Healthcare Corporation H. Jonathan Birks Organizations Foundation Imperial Tobacco Canada Limited L’honorable Juge Ivan Bisaillon Association Epilepsie Abitibi- The Annie & Nathan Steinberg J.P. Metal America Incorporated Professor Maier L. Blostein Temiscamingue Family Foundation KPMG Anne Marie & Jacques Bougie Ayemel Family Foundation The Tecolote Foundation Kruger Incorporated Hélène Boutin The Bannerman Family Foundation The William and Nancy Turner Architectes Lemay et Associés Michael A.S. Boxer The Birks Family Foundation Foundation Litho-Pak Incorporated Kathryn & David Brereton Brainstorm Foundation The Ultramar Foundation Manulife Financial Roy Donald Brown Brigadier Frederick Kisch Foundation The Velan Foundation (Olga & Bob McCain Foods Limited Bernice & Morton Brownstein The Marjorie & Gerald Bronfman Velan, Karen & Peter Velan, Dana & McCarthy Tétrault Foundation Tom Velan, Penny & Ivan Velan) Harold Brownstein Merck Frosst Canada & Company B-Strong Fund - Lindsay Bolger The Wilson Foundation Robert Brun MB MicroBytes Pointe Claire The Lloyd Carr-Harris Foundation Estates Cynthia & Frederick S. Burbidge Minogue Medical Incorporated Jenifer A. Burbidge The Tony Colannino Foundation Rupert Bruce Montreal Port Authority Peter Cafaro The Cole Foundation Audrey Delphine Fisher National Bank Financial Group Suzan Carsley Maxwell Cummings Family Lyle Walker Humphrey Foundation Osler, Hoskin & Harcourt Donald Cayouette Herbert Kelsey Jones Dalkeith School Pizzingrilli Administration André Charron John P. O’Connor Incorporated Fondation Debbie Murray pour SLA Dr. Daniel Chartrand Mildred Roth Recochem Incorporated Franco de Giovanni Fund Priscilla Penfield & Wm. Chester Dorothy Crozier Sexton Reitmans Canada Limited Fondation Desjardins Moreau Joan & Warren Chippindale and Joseph Sexton Rio Tinto Alcan Leonard Ellen Family Foundation Fran & Edmund Clark Rosabelle Hollis Smith Roche Limited, Consulting Group Friends of the Neuro Carol A. Cole Laughlin B. Taylor Schering Canada Corporation Leo & Shirley Goldfarb Foundation Ruth Coleman Corporations John L. Schultz Limited Fondation du Grand Montréal Dr. Donald G. Collins Scotiabank The Hallmont Foundation AECOM Elizabeth & Dr. David Colman Siblin & Associates Limited The Hay Foundation American Iron & Metal Company Lorena & Norman Cook SNC Lavalin Group Incorporated The Hylcan Foundation Incorporated Janet & Gordon Cook The Standard Life Assurance Imperial Tobacco Canada Astral Media Incorporated Harriet & Marvin Corber Company of Canada Foundation AstraZeneca Canada Incorporated Dr. Maria Del Pilar Cortes Nino St. Joseph Communications Fondation Jeunesse-Vie Bell Canada Purdy Crawford

26 David M. Culver Najeeb Khalid Lorna Scherzer Memorial Tributes Steven M. Cummings Dr. Elizabeth Kofron Seymour Schulich of $1000 or more. Lynn Fletcher Curry Dr. Ikuko Koyama Richard Schwartz Bruce Daccord Charlotte Lacasse Paolo Scotti Our deepest sympathies go Joan & Jacques Daccord Kathleen Griffith Laing Alvin Segal out to the family, friends and Philip R. Daccord Dr. Marcelo Lannes Barry H. Shapiro loved ones who made gifts Pearl & Dominic D’Alessandro Mort Lauder David V. Sheridan in memory of the following Anita David Jean Jacques Laurans Dr. Chun Jen Shih individuals: Josette Robertson D’Avignon Ronald E. Lawless Dr. Eric Shoubridge Dr. Lloyd A. Dayes Christopher E. Lax Keniston Warren Simpson Angie Argyrakos Hélène & A. Jean de Grandpré John W. Leopold David E. Simpson Claude Baillargeon Suzanne de Grandpré Rhonda & Robert Levine Dr. David Sinclair Brigitte Boudreault Jean-Guy Desjardins Claire Gohier & Brian Levitt L.E. Smith Raymond Brown Mr. & Mrs. Paul G. Desmarais Mortimer Levy Dr. Jean-Paul Soucy Roslyn Cabot Falconi & Di Bacco Families & Judith & Ralph Loader William E. Stavert Jean Carsley Friends Christianne & Jean Longpré Deirdre Stevenson Beatrice Pinchuk Cohen James B.C. Doak Dylan T. MacKenzie Virginia Stikeman Louis-Philippe de Grandpré Dr. François Dubeau Dr. Lloyd Douglas Maclean Howard Stotland Pierre de Grandpré Eileen Dubrovsky Dr. Mohammad Maleki Tor Oscar Stangeland Helen Desmond Dr. Sydney M. Duder Santo Manna Jay H. Stubina Tony Di Bacco Dr. Jean-Marc Dumas Xeno C Martis J. Robert Swidler Nathan Finkelstein Dr. Heather D. Durham Jill Martis Vickie & John Swidler Alexandra Froome Dr. Gary Dvorkin Chris Mazur Gordon Tani Michael Georgakakis G. Keith Edwards Allison McCain Marjorie & A. Scott Taylor Sophia Geracimo Bina & Leonard Ellen G. Wallace F. McCain C. Robert Taylor Peyman Gohari-Moghadam Anna Engel Dr. Nancy C. McFadyen Leigh Mackenzie Taylor & Boyd Graham Paul Edward Fahey Dr. John W. McMartin Dr. Donald Taylor Nicola Iannacci Sharron Feifer Gertude Meath Claude I. Taylor Gail Inniss Faith & Dr. William Feindel The Honourable Michael A. Meighen Marika F. Teakle George Karpati Marielle Ferland Dr. Denis Melançon Joanne & Benjamin Topor Irene Haruko Kudo Brian Fetherstonhaugh Merilee Merovitz David L. Torrey Guylaine Duchesne Lange Kappy Flanders Dr. Brenda A. Milner Marjorie E. & Eric A.+ Trigg Claude Marcoux Joan & Ted Fletcher Danny Minogue William I.M. Turner, Jr. Glenys McQuinn Gwendolyn Floud Nancy & Stephen T. Molson Edward Victor Amy Menon David Forest Jane & Eric H. Molson David G. Ward Bibiane Ouellette Michael Donald Froome & Family Franca Monti & Egidio Pizzingrilli George B. Waters Louis Pelland Lucette Gauthier Wayne N. Moore Mary G. Webster Dimitrije Pivnicki Ian Gergovich Carolyn & Owen Ness Meredith Webster Jean-Yves Prud’homme Elisabeth & Thomas Gevas The Neuwith Family Eric Williams Angela Rao Jane M. Giffin John A. Neysmith Lynton R. Wilson Jacques Richer Luba Gloor Dr. Dac-Thang Nguyen Arlene & Ted Wise David Rosario Susan & H. James Godber Philip O’Brien Dr. John F. (Ivan) Woods Nathalie Salem Pauline & F. Hubert Godin Patricia O’Connor Kenneth J. Seidman + Deceased Beryl Goldman Dr. André Olivier Jennifer Jane Sloan Royal A. Govain Nello Orsini Helen Snow Commemorative gifts Daniel Groulx Peter G. Pamel Charles Lewis Spector Wendy & Thomas Guay Alex K. Paterson in memory or in honour Jake Dougherty-St Arnaud Hugh G. Hallward Rita Pert of someone special are a Evelyn Tarnofsky Clare Hallward Roberto Pietrovito thoughtful way to remember Jacques Thevenoz Dr. Edith Hamel Marjorie Pike a loved one, to acknowledge Jerry Urovitch Sonia Hanna Derek Pilat a birthday or anniversary, Johanne Valois Douglass Hanson Suzanne Poulin or to thank a doctor, nurse Suzanne Woud Dr. Kenneth E.M. Hastings Dr. Sandy Pritchard or friend. Norman D. Hébert Rita Coveney Pudenz Joan Vogelesang & Fred Heese The Radcliffe-Branch Family In Honour of Tributes Heather Jean Hiscox Dorothy & Cyril Reitman of $1000 or more were made John Howick Jill & Joel Reitman in honour of the following Dr. Jacques Claude Hurtubise Rose-Anna Rémillard individuals: Dr. Leslie Huszar Carolyn & Richard Renaud Dr. Jeffery Hall and Wai Chin & Dr. Paul Hwang Susan Riddell-Fitzpatrick Dr. Martin Veilleux Anne M. Hyde Jean & Douglas Robinson Dr. Line Jacques Joan Ivory André Rochette Martha & Jeffrey Khoury Mary L. McDougall Jasper Marilyn & Harvey Rosenbloom Susan Riddell Fitzpatrick Marilyn Kaplow Dr. Richard L Rovit + Dr. Donatella Tampieri Dr. George Karpati Catherine M. Rowe Gitta & Robert J. Kerr Anne & Jay Rubenstein R. Renee Kessler Dr. Abbas F. Sadikot

27 financial summary

STATEMENT OF SOURCE AND USE OF FUNDS, MNI June 1, 2006 – May 31, 2009

Year ended Year ended Year ended May 31, 2007 May 31, 2008 May 31, 2009

Income: Balance June 1 $ 20,696,104 $ 22,751,118 $ 34,362,570 Research Funding 19,539,823 34,743,154 24,445,703 Endowment Income/Donations 5,215,923 5,685,066 6,451,214 Other 13,775,747 8,419,421 8,754,421 – – – 59,227,597 71,598,759 74,013,908 Less: balance May 31 22,751,118 34,362,570 31,241,150 Total Income 36,476,479 37,236,189 42,772,758

Expenditures: Salary Support Academic 19,591,185 21,247,175 23,147,080 Administrative & Clerical 3,762,451 3,499,915 4,523,050

Non-Salary Research Support 10,023,944 9,961,326 10,409,601 Total expenditures 33,377,580 34,708,416 38,079,731 BALANCE 3,098,899 2,527,773 4,693,027

Capital Expenditures Capital, Building and Interest 3,098,899 2,527,773 4,693,027 Total Capital Expenditures $ 3,098,899 $ 2,527,773 $ 4,693,027 BALANCE – – –

Montreal Neurological Institute Funds in Support of Montreal Neurological Hospital (included in the expenditures above)

2006-2007 2007-2008 2008-2009

Professional Salaries $ 1,222,372 $ 1,412,375 $ 1,632,764 Technical/Clerical Salaries 146,734 224,126 237,357 Other Operating Support 57,003 64,201 23,534 Equipment 946,487 Construction 152,443 147,557

Total $ 1,578,552 $ 1,848,259 $ 2,840,142

28 MNI Annual Expenditures (including MNI operations)

2006-2007 2007-2008 2008-2009

12% 11% 15%

24% 54% 23% 57% 20% 55%

10% 9% 10%

Academic & Research Salaries

Administrative Salaries

Non Salary Research Support

Capital, Building & Interest

Total Annual Funding (including MNI operations)

2006-2007 2007-2008 2008-2009 $36,476,479 $37,236,189 $42,772,758

18% 19% 20%

14% 68% 15% 66% 15% 65%

Research Funding

Endowment Income / Donations

Other

29 In Memoriam

Dr. Jacob Chandy Dr. William Gibson Dr. Ernst Meyer (1910-2007) (1913-2009) (1942-2010) Dr. Chandy was a distinguished alumnus Dr. Gibson was the last living person Dr. Meyer was integral in developing of The Neuro, known as India’s first who attended the opening of The the world’s first operational Positron neurosurgeon and a leading figure in Neuro on September 27, 1934. He Emission Tomograph (PET) at The Indian medical education for over forty was an enthusiastic protagonist of Neuro in 1975. In his research, Dr. years. He trained under Drs. Wilder The Neuro, the Osler Library and McGill. Meyer used both PET and functional Penfield, William Cone and Arthur Dr. Gibson received his medical Magnetic Resonance Imaging (fMRI) Elvidge and in 1949, established India’s degree from McGill and DSc from the to examine the relationship between first Department of Neurology and University of Oxford, and trained at cerebral blood flow and metabolism Neurosurgery at the Christian Medical The Neuro specializing in neurology and under normal and pathological conditions. College and Hospital in Vellore, mod- psychiatry. He was an original member of Dr. Meyer was a passionate musician eled on The Neuro, and sent key members the Faculty of Medicine at the University who shared his love for music gener- of his team to train at The Neuro. of British Columbia, Director of the ously in The Neuro community and Dr. Joseph Stratford Kinsmen Laboratory for Neurological beyond. (1923-2007) Research, and Head of the History Mary Waller Robb Dr. Stratford was known as a wonderful of Medicine and Science Department. (1916-2010) clinical teacher who showed great com- Dr. George Karpati Mrs. Robb was the wife of Professor passion for his patients. He earned his (1934-2009) Emeritus and former Neurologist-in-Chief MD degree from McGill in 1947 and Dr. Karpati was recognized internation- James Preston Robb (1914-2004). She Master’s degree while working at The ally as one of the leading experts on was head nurse at the Montreal General Neuro. After teaching at the University the diagnosis and treatment of neuro- Hospital prior to her marriage. Mother of Saskatchewan, he returned to the muscular disorders. He was the Izaak of the four Robb children, Mary was Montreal General Hospital in 1962 as Walton Killam Chair and Professor of known for the kind help she offered Head of the Division of Neurosurgery, Neurology at McGill University and a the families of young neurologists who where he and Neurologist-in-Chief Dr. distinguished Clinician Scientist with came to The Neuro for advanced training. Donald Baxter established a 30-bed many honours and awards including neurological and neurosurgical ward the Order of Canada and the Royal with a dedicated intensive care unit – Society of Canada. He was a Knight of a first in Canada. the Ordre National du Québec and he James Wright was awarded the 2006 Prix du Québec (1942-2007) (Wilder Penfield). He made seminal Mr. Wright was the husband of dedi- contributions in the area of muscular cated Neuro volunteer Nancy Wright. dystrophy, and was among the first He was a retired lawyer and community to show the localization of dystrophin volunteer. He was known for his service to the muscle fibre surface and to dem- to McGill University as Governor of the onstrate a lack of dystrophin in the Board, and for his active participation in fibres of Duchenne patients. the community. Thérèse Lavoie-Roux (1928-2009) Mme Lavoie-Roux was Quebec Minister of Health and Social Services in the Bourassa government and a federal Senator from 1990-2001. She also served on the McGill University Board of Govenors and on the Advisory Board of the Montreal Neurological Institute from 1992-2002.

The Neuro Lobby: Restored as a Masterpiece of Art. Marie-Eve Thibeault, assistant conservator 30 Realizing that the front lobby was a visitor’s first introduction to The Neuro, Dr. Penfield – working with architect Barnet Phillips – designed the entrance in the Art Deco style, popular in the early 1930s. Since then, the lobby has continued to instill strong feelings about everything from the pursuit of knowledge and the care of patients to the appreciation of art and history. Over the years, the condition of the lobby had deteriorated due to water damage, pollution and re-varnishing and re-painting. In January 2009, Anne Lapointe, a local art conservator specializing in wall paint- ings and architectural finishes, began the metic- ulous restorative work. This enormous task was completed in the summer of 2010 with official “Foyer Feindel” lettering at the entrance, hon- ouring Dr. William Feindel and his immense contributions to his patients, neuroscience and The Neuro. Painted upon the ceiling are three of the six layers of the cerebellum, highlighting the specific nerve and glial cells in each layer inspired by a drawing by the great Italian neurologist Camillo Golgi (1843-1926). Sprawling silver cells, rounded disk nerve cells, and filigree blood vessels dance across the gold ceiling.

31 The Neuro at a glance

Nerve cell fibre tracks. (McConnell Brain Imaging Centre)

The Montreal Neurological + Institute and Hospital 1,400 + – The Neuro – combines a world-class research centre former research, dedicated to tapping into the mysteries of the brain and neurological neurological diseases, with an ultra-specialized hospital and that delivers the highest quality of care for its patients. neurosurgical fellows in 60 countries around the world 1,400

300 + neuroscience graduate students 60 + postdoctoral fellows 22 neurology residents and fellows 19 neurosurgery residents and fellows $30 million research funding per year 50 + research groups

200$30M + scientific articles/year

32 Director of Neuroradiology of Director Tampieri, Donatella Dr. nurses 237 anaesthe­ neuro­ 7 neuroradiologists 3 neurosurgeons 13 neurologists 24

visits/year ambulatory 39,000 surgeries/year 1,800 -

siologists 1,800 + +

muscular disease. muscular neuro and systems, neural complex neuroimmunology, neuroscience, cognitive ing, imag- brain the treatment, and research epilepsy in strengths nationalattention forrenowned inter­ garnered has Neuro The world. the around headlines make to continue scientists of teams multidisciplinary our integrated closely units research With world-clA neuroscience. cognitive and imaging brain to fromcell andmolecular biology neuroscience of spectrum full the spans that information fundamental generate teams research multi-disciplinary Our I nnov a tive with clinical activities, R ass e s e in a rc s titute h -

- many facilities. facilities. many other and unit trials clinical specialty CT, advanced neuro-radiology, interventional for equipment state-of-the-art suites, surgical system. nervous the of disorders and help to technology advanced of cated demicmedical centre, dedia Inourhighly-specialized aca Medic St organizations. professional in visibility high and institutes, sister with partnerships formal rations, collabo- international through out reach we as impact wide world- a have to continue countries, 60 than more from globe. the around positions prominent ship. mentor- and training standing out- offered has Neuro The 1934, in founded was it Since I ntern a te-of-t and MRI scanners, MRI and PET patients with diseases with patients ur former fellows hold fellows former Our

team uses a wide array array wide a uses team a a he hospital has 4 has hospital The l day clinics, a large large a clinics, day tion Ca oday’s trainees, Today’s h re e- a l a Im rt p a ct

- - To obtain additional copies of this report or for more information, please contact: Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec H3A 2B4 External Affairs: Tel: 514 398-1902 Fax: 514 398-8072 [email protected] www.theneuro.com