Portfolio Holdings Listing Select Biotechnology Portfolio As of July

Portfolio Holdings Listing Select Biotechnology Portfolio DUMMY as of July 30, 2021

The portfolio holdings listing (listing) provides information on a fund’s investments as of the date indicated. Top 10 holdings information (top 10 holdings) is also provided for certain equity and high income funds. The listing and top 10 holdings are not part of a fund’s annual/semiannual report or Form N-Q and have not been audited.

The information provided in this listing and top 10 holdings may differ from a fund’s holdings disclosed in its annual/semiannual report and Form N-Q as follows, where applicable: With certain exceptions, the listing and top 10 holdings provide information on the direct holdings of a fund as well as a fund’s pro rata share of any securities and other investments held indirectly through investment in underlying non- money market Fidelity Central Funds. A fund’s pro rata share of the underlying holdings of any investment in high income and floating rate central funds is provided at a fund’s fiscal quarter end. For certain funds, direct holdings in high income or convertible securities are presented at a fund’s fiscal quarter end and are presented collectively for other periods.

For the annual/semiannual report, a fund’s investments include trades executed through the end of the last business day of the period. This listing and the top 10 holdings include trades executed through the end of the prior business day. The listing includes any investment in derivative instruments, and excludes the value of any cash collateral held for securities on loan and a fund’s net other assets. Therefore, the holdings as a percent of fund net assets may not total to 100%.

The presentation of investment holdings by category is similar to that used in other marketing materials.

The fund’s holdings are consistent across all share classes.

The top 10 holdings is presented to illustrate examples of the securities that the fund has bought and the diversity of the areas in which the fund may invest, may not be representative of the fund’s current or future investments, and may change at any time. The top 10 holdings do not include cash, cash equivalents, money market instruments, options, interest rate swaps, fixed income total return swaps and/or futures contracts. Depositary receipts, credit default swaps and equity total return swaps are normally combined with the underlying security.

The most recent annual/semiannual report can be viewed at www.fidelity.com or www.institutional.fidelity.com. Forms N-Q are available on the SEC’s web site at www.sec.gov. Before investing, consider the fund’s investment objectives, risks, charges and expenses. Contact Fidelity for a prospectus containing this information. Read it carefully.

466719.7.0 TOP TEN HOLDINGS % of Net Security Name Market Value Assets AbbVie, Inc. $979,785,516 12.5% Moderna, Inc. $361,098,088 4.6% Biogen, Inc. $298,218,887 3.8% Alnylam Pharmaceuticals, Inc. $256,410,105 3.3% Vertex Pharmaceuticals, Inc. $150,621,785 1.9% Biohaven Pharmaceutical Holding Co. Ltd. $143,665,639 1.8% Arvinas Holding Co. LLC $140,167,972 1.8% Intellia Therapeutics, Inc. $135,552,002 1.7% Argenx SE ADR $125,633,999 1.6% Acceleron Pharma, Inc. $110,863,939 1.4% Top Ten Holdings Total: $2,702,017,932 34.5%

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

2 FULL HOLDINGS LISTING % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Domestic Equities AbbVie, Inc. $979,785,516 12.506% ABBV 00287Y109 US00287Y1091 B92SR70 Moderna, Inc. $361,098,088 4.609% MRNA 60770K107 US60770K1079 BGSXTS3 Biogen, Inc. $298,218,887 3.806% BIIB 09062X103 US09062X1037 2455965 Alnylam Pharmaceuticals, Inc. $256,410,105 3.273% ALNY 02043Q107 US02043Q1076 B00FWN1 Vertex Pharmaceuticals, Inc. $150,621,785 1.923% VRTX 92532F100 US92532F1003 2931034 Biohaven Pharmaceutical Holding Co. Ltd. $143,665,639 1.834% BHVN VGG111961055 BZ8FXC4 Arvinas Holding Co. LLC $140,167,972 1.789% ARVN 04335A105 US04335A1051 BDZ30Q0 Intellia Therapeutics, Inc. $135,552,002 1.730% NTLA 45826J105 US45826J1051 BYZM6C2 Acceleron Pharma, Inc. $110,863,939 1.415% XLRN 00434H108 US00434H1086 BDGTXQ8 Blueprint Medicines Corp. $110,730,435 1.413% BPMC 09627Y109 US09627Y1091 BWY52P3 Seagen, Inc. $107,786,539 1.376% SGEN 81181C104 US81181C1045 BLPK4D2 TG Therapeutics, Inc. $99,456,276 1.269% TGTX 88322Q108 US88322Q1085 B828K63 Mirati Therapeutics, Inc. $99,403,662 1.269% MRTX 60468T105 US60468T1051 BBPK0J0 Adimab LLC $99,265,489 1.267% BIOH.PP Arcus Biosciences, Inc. $97,093,493 1.239% RCUS 03969F109 US03969F1093 BDZT9Y9 Apellis Pharmaceuticals, Inc. $94,087,505 1.201% APLS 03753U106 US03753U1060 BYTQ6X1 PTC Therapeutics, Inc. $86,960,958 1.110% PTCT 69366J200 US69366J2006 B17VCN9 Amgen, Inc. $79,995,633 1.021% AMGN 031162100 US0311621009 2023607 Krystal Biotech, Inc. $78,420,461 1.001% KRYS 501147102 US5011471027 BD6JX35 Fate Therapeutics, Inc. $77,971,684 0.995% FATE 31189P102 US31189P1021 BCZS820 Novavax, Inc. $77,387,351 0.988% NVAX 670002401 US6700024010 BJDQXG4 Gilead Sciences, Inc. $75,193,163 0.960% GILD 375558103 US3755581036 2369174 Arrowhead Pharmaceuticals, Inc. $74,668,706 0.953% ARWR 04280A100 US04280A1007 BYQBFJ8 Cytokinetics, Inc. $69,405,819 0.886% CYTK 23282W605 US23282W6057 BBBSBJ5 Regeneron Pharmaceuticals, Inc. $66,713,945 0.852% REGN 75886F107 US75886F1075 2730190 Natera, Inc. $65,703,903 0.839% NTRA 632307104 US6323071042 BYQRG48 Ultragenyx Pharmaceutical, Inc. $64,090,478 0.818% RARE 90400D108 US90400D1081 BJ62Z18 Incyte Corp. $58,791,182 0.750% INCY 45337C102 US45337C1027 2471950 Exact Sciences Corp. $51,527,246 0.658% EXAS 30063P105 US30063P1057 2719951 United Therapeutics Corp. $49,233,169 0.628% UTHR 91307C102 US91307C1027 2430412 Springworks Therapeutics, Inc. $48,790,724 0.623% SWTX 85205L107 US85205L1070 BGMGM89 Exelixis, Inc. $48,412,476 0.618% EXEL 30161Q104 US30161Q1040 2576941 Scholar Rock Holding Corp. $48,226,469 0.616% SRRK 80706P103 US80706P1030 BFZQ0L8 Neurocrine Biosciences, Inc. $47,359,815 0.605% NBIX 64125C109 US64125C1099 2623911 Kymera Therapeutics, Inc. $47,052,997 0.601% KYMR 501575104 US5015751044 BMPRZV5

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

3 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Morphic Holding, Inc. $46,403,518 0.592% MORF 61775R105 US61775R1059 BK8M4J4 Ionis Pharmaceuticals, Inc. $46,301,584 0.591% IONS 462222100 US4622221004 BDJ0LS6 Horizon Therapeutics PLC $45,962,091 0.587% HZNP IE00BQPVQZ61 BQPVQZ6 Prothena Corp. PLC $44,288,901 0.565% PRTA IE00B91XRN20 B91XRN2 Sarepta Therapeutics, Inc. $44,125,051 0.563% SRPT 803607100 US8036071004 B8DPDT7 Y-mAbs Therapeutics, Inc. $44,055,570 0.562% YMAB 984241109 US9842411095 BG31GH0 Relay Therapeutics, Inc. $42,818,951 0.547% RLAY 75943R102 US75943R1023 BN2R582 Protagonist Therapeutics, Inc. $39,404,509 0.503% PTGX 74366E102 US74366E1029 BDCBCD8 Crinetics Pharmaceuticals, Inc. $38,174,902 0.487% CRNX 22663K107 US22663K1079 BDD19F8 Agios Pharmaceuticals, Inc. $38,133,975 0.487% AGIO 00847X104 US00847X1046 BCBVTX1 Twist Bioscience Corp. $37,819,541 0.483% TWST 90184D100 US90184D1000 BGKG6G7 ALX Oncology Holdings, Inc. $37,671,062 0.481% ALXO 00166B105 US00166B1052 BLN7XQ1 BridgeBio Pharma, Inc. $37,241,875 0.475% BBIO 10806X102 US10806X1028 BK1KWG8 BioAtla, Inc. $37,173,011 0.474% BCAB 09077B104 US09077B1044 BNC5F86 Denali Therapeutics, Inc. $36,438,023 0.465% DNLI 24823R105 US24823R1059 BD2B4V0 Replimune Group, Inc. $34,501,249 0.440% REPL 76029N106 US76029N1063 BDDVW37 Zentalis Pharmaceuticals, Inc. $33,971,020 0.434% ZNTL 98943L107 US98943L1070 BMQ5T49 Arcturus Therapeutics Holdings, Inc. $33,594,910 0.429% ARCT 03969T109 US03969T1097 BKC9SX3 National Resilience, Inc. Series B $32,510,962 0.415% NRS+BPP Intra-Cellular Therapies, Inc. $31,823,086 0.406% ITCI 46116X101 US46116X1019 BHCB0P4 Monte Rosa Therapeutics, Inc. $31,636,155 0.404% GLUE.TMP CRISPR Therapeutics AG $31,528,372 0.402% CRSP CH0334081137 BDHF4K6 Translate Bio, Inc. $29,954,187 0.382% TBIO 89374L104 US89374L1044 BG88WT0 Allakos, Inc. $29,908,434 0.382% ALLK 01671P100 US01671P1003 BDD19P8 Celldex Therapeutics, Inc. $29,316,875 0.374% CLDX 15117B202 US15117B2025 BJLV8T9 Turning Point Therapeutics, Inc. $28,821,176 0.368% TPTX 90041T108 US90041T1088 BJXBP30 Macrogenics, Inc. $28,350,816 0.362% MGNX 556099109 US5560991094 BFDV8K0 Xencor, Inc. $27,882,248 0.356% XNCR 98401F105 US98401F1057 BGCYWN8 ChemoCentryx, Inc. $26,894,013 0.343% CCXI 16383L106 US16383L1061 B6ZL968 Cerevel Therapeutics Holdings $26,238,397 0.335% CERE 15678U128 US15678U1280 BMVMJ12 Karuna Therapeutics, Inc. $26,191,902 0.334% KRTX 48576A100 US48576A1007 BJMLSD2 C4 Therapeutics, Inc. $24,990,182 0.319% CCCC 12529R107 US12529R1077 BKX9NQ0 Graphite Bio, Inc. $23,154,404 0.296% GRH.TMP Ambrx Biopharma, Inc. ADR $22,913,810 0.292% AMA.TMP Zymeworks, Inc. $22,758,068 0.290% ZYME 98985W102 CA98985W1023 BYQHPK7 23andMe Holding Co. Class B $22,654,050 0.289% MEB.TMP 10X Genomics, Inc. $22,522,448 0.287% TXG 88025U109 US88025U1097 BKS3RS7 Revolution Medicines, Inc. $22,496,491 0.287% RVMD 76155X100 US76155X1000 BL71K91 Roivant Sciences Ltd. $22,297,500 0.285% MAAC.TMP

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

4 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Kura Oncology, Inc. $21,796,322 0.278% KURA 50127T109 US50127T1097 BYZD465 Iovance Biotherapeutics, Inc. $21,570,254 0.275% IOVA 462260100 US4622601007 BF0DMK7 Alector, Inc. $21,340,244 0.272% ALEC 014442107 US0144421072 BJ4LDC4 Sage Therapeutics, Inc. $20,808,265 0.266% SAGE 78667J108 US78667J1088 BP4GNK9 Instil Bio, Inc. $20,463,640 0.261% TIL.TMP Rallybio Corp. $20,345,345 0.260% RLYB 75120L100 US75120L1008 BMGTPL0 Arcutis Biotherapeutics, Inc. $20,254,499 0.259% ARQT 03969K108 US03969K1088 BKX9VD3 Nurix Therapeutics, Inc. $20,177,275 0.258% NRIX 67080M103 US67080M1036 BMVLGP2 Century Therapeutics, Inc. $20,138,458 0.257% IPSC.TMP Dicerna Pharmaceuticals, Inc. $20,053,296 0.256% DRNA 253031108 US2530311081 BJ62Z07 Allogene Therapeutics, Inc. $19,956,282 0.255% ALLO 019770106 US0197701065 BFZNYB7 Pliant Therapeutics, Inc. $19,614,826 0.250% PLRX 729139105 US7291391057 BMDWW66 Kodiak Sciences, Inc. $18,978,693 0.242% KOD 50015M109 US50015M1099 BFXC933 Candel Therapeutics, Inc. $18,975,000 0.242% CADL 137404109 US1374041093 BP0TQC5 uniQure B.V. $18,665,266 0.238% QURE NL0010696654 BJFSR88 MannKind Corp. $18,230,494 0.233% MNKD 56400P706 US56400P7069 BF081J4 BioCryst Pharmaceuticals, Inc. $18,117,010 0.231% BCRX 09058V103 US09058V1035 2100362 Repare Therapeutics, Inc. $18,044,350 0.230% RPTX 760273102 US7602731025 BLF0CW7 Royalty Pharma PLC $17,981,504 0.230% RPRX GB00BMVP7Y09 BMVP7Y0 Prelude Therapeutics, Inc. $17,653,303 0.225% PRE.TMP Insmed, Inc. $17,542,752 0.224% INSM 457669307 US4576693075 2614487 Day One Biopharmaceuticals, Inc. $17,472,318 0.223% DAWN 23954D109 US23954D1090 BLB0YH0 Arena Pharmaceuticals, Inc. $17,418,106 0.222% ARNA 040047607 US0400476075 BF3N4P3 Halozyme Therapeutics, Inc. $17,234,941 0.220% HALO 40637H109 US40637H1095 2975098 Aurinia Pharmaceuticals, Inc. $17,134,226 0.219% AUPH 05156V102 CA05156V1022 BFWLC09 Forma Therapeutics Holdings, Inc. $17,064,701 0.218% FMTX 34633R104 US34633R1041 BLB2Y98 Tenaya Therapeutics, Inc. $16,668,668 0.213% TEN.TMP Invitae Corp. $16,021,952 0.205% NVTA 46185L103 US46185L1035 BVVCNT1 Rubius Therapeutics, Inc. $15,974,140 0.204% RUBY 78116T103 US78116T1034 BDD1B07 Omega Therapeutics, Inc. $15,882,350 0.203% OMGA.TMP Design Therapeutics, Inc. $15,480,000 0.198% DSGN 25056L103 US25056L1035 BMFK3H6 Taysha Gene Therapies, Inc. $15,264,425 0.195% TSHA 877619106 US8776191061 BNC1BX1 Essa Pharma, Inc. $15,008,100 0.192% EPIX 29668H708 CA29668H7085 BDTYY56 CareDx, Inc. $15,001,140 0.191% CDNA 14167L103 US14167L1035 BP3YM74 ValenzaBio, Inc. Series A $14,999,991 0.191% VZB+APP Madrigal Pharmaceuticals, Inc. $14,542,273 0.186% MDGL 558868105 US5588681057 BD59BS7 Novocure Ltd. $14,417,338 0.184% NVCR JE00BYSS4X48 BYSS4X4 G1 Therapeutics, Inc. $14,083,416 0.180% GTHX 3621LQ109 US3621LQ1099 BF0QXG9 Kinnate Biopharma, Inc. $13,796,159 0.176% KNT.TMP

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

5 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Rocket Pharmaceuticals, Inc. $13,630,800 0.174% RCKT 77313F106 US77313F1066 BDFKQ07 Afferent Pharmaceuticals, Inc. rights 12/31/24 $13,487,546 0.172% AFFINTRT Rain Therapeutics, Inc. $13,320,000 0.170% RAIN 75082Q105 US75082Q1058 BN2RM92 Aclaris Therapeutics, Inc. $12,602,249 0.161% ACRS 00461U105 US00461U1051 BYV2W40 Sutro Biopharma, Inc. $12,556,219 0.160% STRO 869367102 US8693671021 BF12XC2 Edgewise Therapeutics, Inc. $12,495,136 0.159% EWTX 28036F105 US28036F1057 BKY5JZ8 Reata Pharmaceuticals, Inc. $12,409,700 0.158% RETA 75615P103 US75615P1030 BYY9FX8 Vaxcyte, Inc. $12,138,957 0.155% PCVX 92243G108 US92243G1085 BKPVGH6 Amicus Therapeutics, Inc. $12,115,098 0.155% FOLD 03152W109 US03152W1099 B19FQ48 Deciphera Pharmaceuticals, Inc. $12,110,628 0.155% DCPH 24344T101 US24344T1016 BZ1LFB2 ORIC Pharmaceuticals, Inc. $12,060,827 0.154% ORIC 68622P109 US68622P1093 BKVDFF7 Epizyme, Inc. $11,928,265 0.152% EPZM 29428V104 US29428V1044 B9Z1QZ7 Vera Therapeutics, Inc. $11,812,522 0.151% VERA.TMP Xenon Pharmaceuticals, Inc. $11,108,029 0.142% XENE 98420N105 CA98420N1050 BRJ3GY4 Centessa Pharmaceuticals PLC ADR $10,889,664 0.139% CNTA 152309100 US1523091007 BLB0YQ9 Keros Therapeutics, Inc. $10,851,805 0.139% KROS 492327101 US4923271013 BM7V485 Aldeyra Therapeutics, Inc. $10,697,008 0.137% ALDX 01438T106 US01438T1060 BLD36T3 Syros Pharmaceuticals, Inc. $10,655,083 0.136% SYRS 87184Q107 US87184Q1076 BYMX5N2 Inozyme Pharma, Inc. $10,219,303 0.130% INZY 45790W108 US45790W1080 BMVLGY1 Chinook Therapeutics, Inc. $10,144,142 0.129% KDNY 16961L106 US16961L1061 BMWXTQ9 Kronos Bio, Inc. $10,130,030 0.129% KNS.TMP PMV Pharmaceuticals, Inc. $9,876,504 0.126% PMVP 69353Y103 US69353Y1038 BMW5084 Absci Corp. $9,857,555 0.126% ABSI 00091E109 US00091E1091 BN94K69 Cullinan Oncology, Inc. $9,835,594 0.126% CGEM 230031106 US2300311063 BM90J52 Applied Therapeutics, Inc. $9,803,504 0.125% APLT 03828A101 US03828A1016 BJL38Z1 Axsome Therapeutics, Inc. $9,776,745 0.125% AXSM 05464T104 US05464T1043 BYZR4X4 BioXcel Therapeutics, Inc. $9,000,694 0.115% BTAI 09075P105 US09075P1057 BF4VBS8 Silverback Therapeutics, Inc. $8,986,741 0.115% SBT.TMP Hookipa Pharma, Inc. $8,863,218 0.113% HOOK 43906K100 US43906K1007 BJ5K4M7 Nuvation Bio, Inc. $8,640,000 0.110% PNA.PIPE Seer, Inc. Class A $8,405,267 0.107% SER.PIPE Ikena Oncology, Inc. $8,269,198 0.106% IKNA.TMP Pacific Biosciences of California, Inc. $8,110,866 0.104% PACB 69404D108 US69404D1081 B4N8MH9 Homology Medicines, Inc. $7,969,659 0.102% FIXX 438083107 US4380831077 BFMMJ23 Veracyte, Inc. $7,851,472 0.100% VCYT 92337F107 US92337F1075 BFTWZY0 Akouos, Inc. $7,789,725 0.099% AKUS 00973J101 US00973J1016 BKPVFN5 Stoke Therapeutics, Inc. $7,731,131 0.099% STOK 86150R107 US86150R1077 BJQ05Z6 Erasca, Inc. $7,719,348 0.099% ERAS 29479A108 US29479A1088 BNLYBF3 Aristea Therapeutics, Inc. Series B $7,711,608 0.098% ART+BPP

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

6 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Ideaya Biosciences, Inc. $7,680,750 0.098% IDYA 45166A102 US45166A1025 BK0VHF6 Evelo Biosciences, Inc. $7,680,210 0.098% EVLO 299734103 US2997341035 BFMFL82 Recursion Pharmaceuticals, Inc. $7,596,605 0.097% RXRX 75629V104 US75629V1044 BM9FJ13 Scorpion Therapeutics, Inc. Series B $7,500,000 0.096% SCT+BPP iTeos Therapeutics, Inc. $7,297,454 0.093% ITOS 46565G104 US46565G1040 BMWXFT4 Marinus Pharmaceuticals, Inc. $6,979,046 0.089% MRNS 56854Q200 US56854Q2003 BM8MVZ3 Codiak Biosciences, Inc. $6,963,925 0.089% CDAK 192010106 US1920101060 BJQ31P7 Janux Therapeutics, Inc. $6,939,436 0.089% JANX 47103J105 US47103J1051 BMFX8Y7 RAPT Therapeutics, Inc. $6,857,689 0.088% RAPT 75382E109 US75382E1091 BK5T6R0 Atara Biotherapeutics, Inc. $6,715,361 0.086% ATRA 046513107 US0465131078 BP4WT09 ImmunoGen, Inc. $6,682,200 0.085% IMGN 45253H101 US45253H1014 2457864 Annexon, Inc. $6,516,722 0.083% ANNX 03589W102 US03589W1027 BMVV9R5 Eledon Pharmaceuticals, Inc. $6,516,680 0.083% ELDN 28617K101 US28617K1016 BM90L23 Maravai LifeSciences Holdings, Inc. $6,450,399 0.082% MRVI 56600D107 US56600D1072 BMCWKZ2 Spruce Biosciences, Inc. $6,431,094 0.082% SPRB 85209E109 US85209E1091 BM8HVW5 Prometheus Biosciences, Inc. $6,316,164 0.081% RXDX 74349U108 US74349U1088 BMZ9Z11 Global Blood Therapeutics, Inc. $6,207,080 0.079% GBT 37890U108 US37890U1088 BZ05388 Passage Bio, Inc. $6,114,312 0.078% PASG 702712100 US7027121000 BKTHM05 IGM Biosciences, Inc. $6,077,918 0.078% IGMS 449585108 US4495851085 BKS3SM8 EQRx, Inc. Series B $6,054,196 0.077% EQR+BPP Tango Therapeutics, Inc. $6,034,500 0.077% BCTG.TMP Praxis Precision Medicines, Inc. $5,945,612 0.076% PRAX 74006W108 US74006W1080 BNGFSD8 Neximmune, Inc. $5,607,000 0.072% NEXI 65344D109 US65344D1090 BNDC2M9 Absci Corp. $5,388,462 0.069% ABS.TMP Theravance Biopharma, Inc. $5,367,230 0.069% TBPH KYG8807B1068 BMNDK09 4D Molecular Therapeutics, Inc. $5,343,767 0.068% FDMT 35104E100 US35104E1001 BKLXFX5 Surface Oncology, Inc. $5,320,443 0.068% SURF 86877M209 US86877M2098 BZ57GY6 Immunic, Inc. $5,316,296 0.068% IMUX 4525EP101 US4525EP1011 BJ0LV13 Vor Biopharma, Inc. $5,257,973 0.067% VOR.TMP Terns Pharmaceuticals, Inc. $5,171,318 0.066% TERN 880881107 US8808811074 BMDJ0C9 Geron Corp. $5,013,231 0.064% GERN 374163103 US3741631036 2370381 Imago BioSciences, Inc. $4,997,696 0.064% IMGO 45250K107 US45250K1079 BNLYJ60 Poseida Therapeutics, Inc. $4,989,945 0.064% PSTX 73730P108 US73730P1084 BJ4SF41 Seres Therapeutics, Inc. $4,883,714 0.062% MCRB 81750R102 US81750R1023 BYNQNP8 Guardant Health, Inc. $4,853,160 0.062% GH 40131M109 US40131M1099 BFXC911 Allovir, Inc. $4,775,162 0.061% ALVR 019818103 US0198181036 BL9XBL4 Bolt Biotherapeutics, Inc. $4,716,450 0.060% BOLT 097702104 US0977021049 BMDJ397 Kiniksa Pharmaceuticals Ltd. $4,683,928 0.060% KNSA BMG5269C1010 BD0MGM0 Avidity Biosciences, Inc. $4,547,196 0.058% RNA 05370A108 US05370A1088 BMWHPY1

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

7 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Werewolf Therapeutics, Inc. $4,430,080 0.057% HOWL 95075A107 US95075A1079 BLGXXZ5 Biomea Fusion, Inc. $4,430,033 0.057% BMEA 09077A106 US09077A1060 BNKF6N0 Rigel Pharmaceuticals, Inc. $4,391,200 0.056% RIGL 766559603 US7665596034 2833936 Heron Therapeutics, Inc. $4,383,165 0.056% HRTX 427746102 US4277461020 BJ0XLZ3 Verve Therapeutics, Inc. $4,326,504 0.055% VERV 92539P101 US92539P1012 BNKGXX2 Merus BV $4,241,520 0.054% MRUS NL0011606264 BZBY005 Foghorn Therapeutics, Inc. $4,018,509 0.051% FHTX 344174107 US3441741077 BMF7DT9 Gritstone Bio, Inc. $4,008,448 0.051% GRTS 39868T105 US39868T1051 BF12XF5 Jounce Therapeutics, Inc. $3,986,307 0.051% JNCE 481116101 US4811161011 BDRW1N9 TCR2 Therapeutics, Inc. $3,845,204 0.049% TCRR 87808K106 US87808K1060 BJ2JSX6 Lexicon Pharmaceuticals, Inc. $3,702,019 0.047% LXRX 528872302 US5288723027 BWFZX59 Aerovate Therapeutics, Inc. $3,678,325 0.047% AVTE 008064107 US0080641071 BLR8K47 Nektar Therapeutics $3,673,243 0.047% NKTR 640268108 US6402681083 2454445 Selecta Biosciences, Inc. $3,573,194 0.046% SELB 816212104 US8162121045 BZB1WS8 ACADIA Pharmaceuticals, Inc. $3,512,582 0.045% ACAD 004225108 US0042251084 2713317 Sangamo Therapeutics, Inc. $3,454,807 0.044% SGMO 800677106 US8006771062 2573083 Vor Biopharma, Inc. $3,411,087 0.044% VOR 929033108 US9290331084 BLCD876 Nuvation Bio, Inc. $3,356,998 0.043% NUL.TMP Longboard Pharmaceuticals, Inc. $3,339,900 0.043% LBPH 54300N103 US54300N1037 BLR6S36 Angion Biomedica Corp. $3,321,875 0.042% ANGN 03476J107 US03476J1079 BMD8P43 Kalvista Pharmaceuticals, Inc. $3,137,006 0.040% KALV 483497103 US4834971032 BD06CS0 Generation Bio Co. $2,980,554 0.038% GBIO 37148K100 US37148K1007 BMC2Z79 Aerie Pharmaceuticals, Inc. $2,935,759 0.037% AERI 00771V108 US00771V1089 BFRTDG1 aTyr Pharma, Inc. $2,879,367 0.037% LIFE 002120202 US0021202025 BGMGBW6 CytomX Therapeutics, Inc. $2,754,691 0.035% CTMX 23284F105 US23284F1057 BYWVTY5 Zymergen, Inc. $2,654,129 0.034% ZY 98985X100 US98985X1000 BMF1M49 Nuvalent, Inc. Class A $2,624,350 0.033% NUVL 670703107 US6707031075 BMVBZD3 Revance Therapeutics, Inc. $2,561,948 0.033% RVNC 761330109 US7613301099 BJFSR99 Verrica Pharmaceuticals, Inc. $2,535,354 0.032% VRCA 92511W108 US92511W1080 BZ1NTH2 Shattuck Labs, Inc. $2,445,029 0.031% STTK 82024L103 US82024L1035 BM8FWT3 Cyclerion Therapeutics, Inc. $2,436,499 0.031% CYCN 23255M105 US23255M1053 BJHGB11 Monte Rosa Therapeutics, Inc. $2,368,632 0.030% GLUE 61225M102 US61225M1027 BP7KZP7 Legend Biotech Corp. ADR $2,323,362 0.030% LEGN 52490G102 US52490G1022 BMX9K07 Graphite Bio, Inc. $2,311,152 0.029% GRPH 38870X104 US38870X1046 BP7L2W6 IMARA, Inc. $2,227,638 0.028% IMRA 45249V107 US45249V1070 BH4GV10 Solid Biosciences, Inc. $2,147,742 0.027% SLDB 83422E105 US83422E1055 BFFXYQ2 Century Therapeutics, Inc. $1,953,050 0.025% IPSC 15673T100 US15673T1007 BNK9MY5 Albireo Pharma, Inc. $1,915,869 0.024% ALBO 01345P106 US01345P1066 BYMP0T9 Nkarta, Inc. $1,911,952 0.024% NKTX 65487U108 US65487U1088 BK80YJ8

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

8 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Atea Pharmaceuticals, Inc. $1,883,008 0.024% AVIR 04683R106 US04683R1068 BLN9Z50 ContraFect Corp. $1,879,993 0.024% CFRX 212326300 US2123263004 BKSLTN0 Editas Medicine, Inc. $1,724,172 0.022% EDIT 28106W103 US28106W1036 BZ8FPH3 Ambrx Biopharma, Inc. ADR $1,702,883 0.022% AMAM 02290A102 US02290A1025 BNKCPN4 Acumen Pharmaceuticals, Inc. $1,657,908 0.021% ABOS 00509G209 US00509G2093 BLR8WK7 Yumanity Therapeutics, Inc. $1,593,043 0.020% YTI.PP Fulcrum Therapeutics, Inc. $1,540,707 0.020% FULC 359616109 US3596161097 BJDX8Z9 Reneo Pharmaceuticals, Inc. $1,535,625 0.020% RPHM 75974E103 US75974E1038 BMHR7T5 LogicBio Therapeutics, Inc. $1,534,493 0.020% LOGC 54142F102 US54142F1021 BGPF6R0 Decibel Therapeutics, Inc. $1,526,532 0.019% DBTX 24343R106 US24343R1068 BMFHPM6 Adagio Theraputics, Inc. Series B $1,491,438 0.019% ADGO.BPP Olema Pharmaceuticals, Inc. $1,455,690 0.019% OLMA 68062P106 US68062P1066 BMZ4LN0 Rhythm Pharmaceuticals, Inc. $1,439,877 0.018% RYTM 76243J105 US76243J1051 BF2YWG4 Ikena Oncology, Inc. $1,408,211 0.018% IKNA 45175G108 US45175G1085 BNTB3M7 Allena Pharmaceuticals, Inc. $1,365,083 0.017% ALL.TMP Kaleido Biosciences, Inc. $1,354,568 0.017% KLDO 483347100 US4833471000 BJ4T016 Axcella Health, Inc. $1,350,307 0.017% AXLA 05454B105 US05454B1052 BKBS529 Ocular Therapeutix, Inc. $1,323,986 0.017% OCUL 67576A100 US67576A1007 BNZB1X8 Foghorn Therapeutics, Inc. $1,307,386 0.017% FHT.TMP Seer, Inc. $1,306,346 0.017% SEER 81578P106 US81578P1066 BMCWDS6 Mersana Therapeutics, Inc. $1,282,666 0.016% MRSN 59045L106 US59045L1061 BF3NP05 Instil Bio, Inc. $1,231,090 0.016% TIL 45783C101 US45783C1018 BLFF921 Equillium, Inc. $1,137,116 0.015% EQ 29446K106 US29446K1060 BGV8J85 Icosavax, Inc. $1,120,735 0.014% ICVX 45114M109 US45114M1099 BMGTPV0 Corcept Therapeutics, Inc. $1,087,496 0.014% CORT 218352102 US2183521028 B00SCY1 Yumanity Therapeutics, Inc. $1,074,138 0.014% YMTX 98872L102 US98872L1026 BN4J3J3 Kronos Bio, Inc. $1,069,044 0.014% KRON 50107A104 US50107A1043 BM8FWV5 Inhibikase Therapeutics, Inc. $983,591 0.013% IKT 45719W106 US45719W1062 BHZSB26 Molecular Templates, Inc. $972,398 0.012% MTEM 608550109 US6085501095 BYXC6T1 Vera Therapeutics, Inc. $910,800 0.012% VERA 92337R101 US92337R1014 BL55460 ElevateBio LLC Series C $908,637 0.012% ELB+CPP X4 Pharmaceuticals, Inc. $878,778 0.011% XFOR 98420X103 US98420X1037 BFY8WQ4 Talaris Therapeutics, Inc. $828,600 0.011% TALS 87410C104 US87410C1045 BN2S6Y8 Verastem, Inc. $821,066 0.010% VSTM 92337C104 US92337C1045 B4Z1Y92 Harmony Biosciences Holdings, Inc. $800,496 0.010% HRMY 413197104 US4131971040 BKSGZN7 Allena Pharmaceuticals, Inc. $800,352 0.010% ALNA 018119107 US0181191075 BYZ0RD4 Mirum Pharmaceuticals, Inc. $781,283 0.010% MIRM 604749101 US6047491013 BJDX8Y8 Metacrine, Inc. $775,517 0.010% MTCR 59101E103 US59101E1038 BKY4502 Gemini Therapeutics, Inc. $770,545 0.010% GMTX 36870G105 US36870G1058 BKPSYH3

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

9 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Coherus BioSciences, Inc. $761,950 0.010% CHRS 19249H103 US19249H1032 BRK0149 AVROBIO, Inc. $750,381 0.010% AVRO 05455M100 US05455M1009 BF2G3Y5 Minerva Neurosciences, Inc. $725,841 0.009% NERV 603380106 US6033801068 BNB7PK5 OptiNose, Inc. $650,687 0.008% OPTN 68404V100 US68404V1008 BYZ2JT0 Myovant Sciences Ltd. $645,682 0.008% MYOV BMG637AM1024 BD3WG49 Nuvation Bio, Inc. $645,408 0.008% NUVB 67080N101 US67080N1019 BLNB9R6 BioMarin Pharmaceutical, Inc. $640,235 0.008% BMRN 09061G101 US09061G1013 2437071 Radius Health, Inc. $608,967 0.008% RDUS 750469207 US7504692077 BM68KK1 Magenta Therapeutics, Inc. $518,336 0.007% MGTA 55910K108 US55910K1088 BFMLGF2 Silverback Therapeutics, Inc. $514,094 0.007% SBTX 82835W108 US82835W1080 BMCR7V2 Aravive, Inc. $511,367 0.007% ARAV 03890D108 US03890D1081 BGSGXX5 Geron Corp. warrants 12/31/25 $501,422 0.006% GERN.WT 374163129 US3741631291 Berkeley Lights, Inc. $464,916 0.006% BLI 084310101 US0843101017 BL5C535 Cyteir Therapeutics, Inc. $456,225 0.006% CYT 23284P103 US23284P1030 BM95GX4 Pulmonx Corp. $329,178 0.004% LUNG 745848101 US7458481014 BL72R71 Prelude Therapeutics, Inc. $322,931 0.004% PRLD 74065P101 US74065P1012 BKX8YL9 Cyclerion Therapeutics, Inc. $275,894 0.004% CYCN.TMP X4 Pharmaceuticals, Inc. warrants 4/12/24 $254,607 0.003% XFORWWT 98420X111 US98420X1110 BJ0CJD4 Sana Biotechnology, Inc. $252,332 0.003% SANA 799566104 US7995661045 BMFJJ97 Chiasma, Inc. warrants 12/16/24 $206,913 0.003% CHIAWT Cabaletta Bio, Inc. $134,034 0.002% CABA 12674W109 US12674W1099 BK5MWR1 Oragenics, Inc. $124,396 0.002% ORN.PIPE Cortexyme, Inc. $110,025 0.001% CRTX 22053A107 US22053A1079 BJL3925 FibroGen, Inc. $107,003 0.001% FGEN 31572Q808 US31572Q8087 BSDRYR8 MedAvail Holdings, Inc. $23,438 0.000% MYOS.PIP Aradigm Corp. $6,808 0.000% ARDM.PP Chinook Therapeutics, Inc. rights $5,791 0.000% KDNY.RT Syros Pharmaceuticals, Inc. warrants 10/10/22 $4,635 0.000% SYRSWWT 87184Q115 US87184Q1159 BJMYRT0 Precipio, Inc. $1,633 0.000% TBI.PIPE Aradigm Corp. $549 0.000% ARDM.TMP Afferent Pharmaceuticals, Inc. Series C $83 0.000% AFFI+CPP Stemcentrx, Inc. rights 12/31/21 $9 0.000% STEM.RT Royalty Pharma PLC $0 0.000% RPH.PP Domestic Equities Total: $7,297,920,771 93.2%

Developed Markets

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

10 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Argenx SE ADR $125,633,999 1.604% ARGX 04016X101 US04016X1019 BDVLM39 Ascendis Pharma A/S sponsored ADR $77,935,550 0.995% ASND 04351P101 US04351P1012 BV9G6B8 BioNTech SE ADR $56,222,714 0.718% BNTX 09075V102 US09075V1026 BK6H543 UCB SA $33,827,274 0.432% *UCB BE0003739530 5596991 Idorsia Ltd. $30,107,839 0.384% *IDIA CH0363463438 BF0YK62 Zealand Pharma A/S $16,022,359 0.205% *ZEAL DK0060257814 B0SDJB4 ADC Therapeutics SA $15,890,208 0.203% ADCT CH0499880968 BK6H4Z7 Evotec OAI AG $15,871,847 0.203% *EVTC DE0005664809 5811917 Immunocore Holdings PLC $12,985,464 0.166% *IMCRLU GH Research PLC $12,298,316 0.157% GHRS IE000GID8VI0 BP6C0S2 Pharvaris BV $9,800,279 0.125% PHVS NL00150005Y4 BMZ2X38 Fusion Pharmaceuticals, Inc. $7,835,760 0.100% FUSN 36118A100 CA36118A1003 BJK0NH0 Sensorion SA $7,439,994 0.095% *ALSEN FR0012596468 BWSW4N2 Bicycle Therapeutics PLC ADR $6,681,630 0.085% BCYC 088786108 US0887861088 BKDQKM6 Olink Holding AB ADR $4,518,033 0.058% OLK 680710100 US6807101000 BMFPJN9 Autolus Therapeutics PLC ADR $4,213,376 0.054% AUTL 05280R100 US05280R1005 BFMLGR4 Gamida Cell Ltd. $4,102,546 0.052% GMDA IL0011552663 BGT0TL6 Compugen Ltd. $3,499,485 0.045% CGEN IL0010852080 2620859 Arix Bioscience PLC $3,491,344 0.045% *ARIXBI GB00BD045071 BD04507 ProQR Therapeutics BV $2,902,734 0.037% PRQR NL0010872495 BQRX1W2 Galapagos Genomics NV sponsored ADR $2,814,928 0.036% GLPG 36315X101 US36315X1019 B292NQ7 Cellectis SA sponsored ADR $1,391,672 0.018% CLLS 15117K103 US15117K1034 BWFKZT2 NuCana PLC ADR $1,329,452 0.017% NCNA 67022C106 US67022C1062 BZ60NF4 Genmab A/S ADR $968,339 0.012% GMAB 372303206 US3723032062 BBC9WC7 Developed Markets Total: $457,785,141 5.8%

Emerging Markets Zai Lab Ltd. ADR $26,846,702 0.343% ZLAB 98887Q104 US98887Q1040 BD9GVY0 Connect Biopharma Holdings Ltd. ADR $22,241,105 0.284% CNTB 207523101 US2075231017 BMFPF31 Antengene Corp. $3,803,200 0.049% *ACHKL KYG039571008 BMW9BX8 Emerging Markets Total: $52,891,007 0.7%

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917

11 % of Net Security Name Market Value Assets Ticker CUSIP ISIN SEDOL Cash and Other Securities Fidelity Cash Central Fund 0.06% $63,884,121 0.815% CF.TAXMM 31635A105 US31635A1051 Cash and Other Securities Total: $63,884,121 0.8%

466719.7.0 Fidelity Distributors Company, LLC 500 Salem Street

Not Part of Annual or Semiannual Report Smithfield, RI 02917