Why GM Crops Have Failed to Deliver on Their Promises
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2,4-Dichlorophenoxyacetic Acid
2,4-Dichlorophenoxyacetic acid 2,4-Dichlorophenoxyacetic acid IUPAC (2,4-dichlorophenoxy)acetic acid name 2,4-D Other hedonal names trinoxol Identifiers CAS [94-75-7] number SMILES OC(COC1=CC=C(Cl)C=C1Cl)=O ChemSpider 1441 ID Properties Molecular C H Cl O formula 8 6 2 3 Molar mass 221.04 g mol−1 Appearance white to yellow powder Melting point 140.5 °C (413.5 K) Boiling 160 °C (0.4 mm Hg) point Solubility in 900 mg/L (25 °C) water Related compounds Related 2,4,5-T, Dichlorprop compounds Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) 2,4-Dichlorophenoxyacetic acid (2,4-D) is a common systemic herbicide used in the control of broadleaf weeds. It is the most widely used herbicide in the world, and the third most commonly used in North America.[1] 2,4-D is also an important synthetic auxin, often used in laboratories for plant research and as a supplement in plant cell culture media such as MS medium. History 2,4-D was developed during World War II by a British team at Rothamsted Experimental Station, under the leadership of Judah Hirsch Quastel, aiming to increase crop yields for a nation at war.[citation needed] When it was commercially released in 1946, it became the first successful selective herbicide and allowed for greatly enhanced weed control in wheat, maize (corn), rice, and similar cereal grass crop, because it only kills dicots, leaving behind monocots. Mechanism of herbicide action 2,4-D is a synthetic auxin, which is a class of plant growth regulators. -
Plant Molecular Farming: a Viable Platform for Recombinant Biopharmaceutical Production
plants Review Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production Balamurugan Shanmugaraj 1,2, Christine Joy I. Bulaon 2 and Waranyoo Phoolcharoen 1,2,* 1 Research Unit for Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand; [email protected] 2 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences Chulalongkorn University, Bangkok 10330, Thailand; [email protected] * Correspondence: [email protected]; Tel.: +66-2-218-8359; Fax: +66-2-218-8357 Received: 1 May 2020; Accepted: 30 June 2020; Published: 4 July 2020 Abstract: The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing steadily, which is attracting global attention for the development of new recombinant protein production technologies and the engineering of conventional established expression systems based on bacteria or mammalian cell cultures. Since the advancements of plant genetic engineering in the 1980s, plants have been used for the production of economically valuable, biologically active non-native proteins or biopharmaceuticals, the concept termed as plant molecular farming (PMF). PMF is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. The development and improvement of the transient expression system has significantly reduced the protein production timeline and greatly improved the protein yield in plants. The major factors that drive the plant-based platform towards potential competitors for the conventional expression system are cost-effectiveness, scalability, flexibility, versatility, and robustness of the system. Many biopharmaceuticals including recombinant vaccine antigens, monoclonal antibodies, and other commercially viable proteins are produced in plants, some of which are in the pre-clinical and clinical pipeline. -
US EPA, Pesticide Product Label, WIDESTRIKE 3 INSECT
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION October 18, 2016 Stephanie L. Burton US Regulatory Manager Dow AgroSciences LLC 9330 Zionsville Road Indianapolis, IN 46268-1054 Subject: PRIA (Pesticide Registration Improvement Act) Amendment – to update the terms of registration related to gene flow and revise the product label. Product Name: WideStrike® 3 Insect Resistant Cotton EPA Registration Number: 68467-19 Application Date: June 23, 2016 OPP Decision Number: 518794 Dear Ms. Burton: The amendment referred to above, submitted in connection with registration under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, are acceptable provided you comply with the revised terms of registration as set forth below: 1. Submit/cite all data required for registration of your product under FIFRA § 3(c)(5) when the Agency requires all registrants of similar products to submit such data. 2. Gene Flow The following information regarding commercial production must be included in the grower guide for WideStrike® 3 Insect Resistant Cotton: a) No planting of WideStrike® 3 Insect Resistant Cotton is permitted south of Route 60 (near Tampa) in Florida. b) Commercial culture of WideStrike® 3 Insect Resistant Cotton is prohibited in Hawaii, Puerto Rico, and the US Virgin Islands. The following information regarding test plots and seed production must appear in contracts or on bags of WideStrike® 3 Insect Resistant Cotton intended for the following purposes: Page 2 of 10 EPA Reg. No. 68467-19 OPP Decision No. 518794 a) Test plots or breeding nurseries, regardless of the plot size, established in Hawaii must not be planted within 3 miles of Gossypium tomentosum. -
Monsanto Company in Microsoft Word Format Together with a Copy of the Transmittal Letter That Accompanies the Filing of Two Paper Copies of the Submission
From: Letzler, Kenneth [mailto:[email protected]] Sent: Thursday, December 31, 2009 1:03 PM To: ATR-Agricultural Workshops Subject: Comment Attached please find a comment submitted on behalf of Monsanto Company in Microsoft Word format together with a copy of the transmittal letter that accompanies the filing of two paper copies of the submission. _____________________________ U.S. Treasury Circular 230 Notice Any U.S. federal tax advice included in this communication (including any attachments) was not intended or written to be used, and cannot be used, for the purpose of (i) avoiding U.S. federal tax-related penalties or (ii) promoting, marketing or recommending to another party any tax-related matter addressed herein. _____________________________ This communication may contain information that is legally privileged, confidential or exempt from disclosure. If you are not the intended recipient, please note that any dissemination, distribution, or copying of this communication is strictly prohibited. Anyone who receives this message in error should notify the sender immediately by telephone or by return e-mail and delete it from his or her computer. ---------------------------------------------------------------------- For more information about Arnold & Porter LLP, click here: http://www.arnoldporter.com Competition and Innovation in American Agriculture A Response to the American Antitrust Institute’s “Transgenic Seed Platforms: Competition Between a Rock and a Hard Place?” Submitted on Behalf of Monsanto Company In Response to the Request for Comments by the United States Department of Agriculture and United States Department of Justice, Antitrust Division, in Connection with Their Hearings on “Agriculture and Antitrust Enforcement Issues in Our 21st Century Economy” Vandy Howell, Ph.D. -
Dow Agrosciences
Dow AgroSciences LLC (Dow AgroSciences) markets crop protection Dow AgroSciences products and seeds for a broad spectrum of crops, including maize, soybean, cotton and forage. The company began in the 1950s as the agricultural unit of The Dow Chemical Company. As a joint venture Corporate Data of The Dow Chemical Company and Eli Lilly & Co., it was known as Headquarters: Indianapolis, Indiana, USA DowElanco from 1989 onwards. In 1997, The Dow Chemical Company Ownership type: Listed Group revenue (2014): USD 729,000,0000 acquired 100% ownership.* Global Index – Commitment Performance Transparency Innovation Field Crop Seed Companies 1.27 1.46 2.05 0.25 Dow AgroSciences ranks in the lower 5 range of the Global Index of Field Crop Seed Companies. It has clear rank out of 7 approaches to Public Policy & Stakeholder A Governance & 1.13 score 1.38 Engagement and existing breeding Strategy B Public Policy & 2.68 programs for resistance to pests and Stakeholder Engagement diseases, abiotic stress tolerance and C Genetic Resources & 1.09 Intellectual Property yield, although it is not clear to what extent these programs D Research & 1.31 specifically target the development of varieties suitable for Development E Marketing & 1.11 Index countries and smallholder farmers. Seed sales were Sales found only in Latin American Index countries. Given the F Capacity 2.08 indications of research and capacity-building activities rel- Building G Local Seed Sector 0.91 evant for improved access to seeds for smallholder farmers in Advancement other regions, the company is encouraged to develop its seed 0 1 2 3 4 5 business serving smallholder farmers on a more global scale. -
Dow Agrosciences Petitions (09-233- 01P, 09-349-01P, and 11-234-01P) for Determinations of Nonregulated Status for 2,4-D-Resistant Corn and Soybean Varieties
Dow AgroSciences Petitions (09-233- 01p, 09-349-01p, and 11-234-01p) for Determinations of Nonregulated Status for 2,4-D-Resistant Corn and Soybean Varieties Draft Environmental Impact Statement—2013 Agency Contact: Sid Abel Biotechnology Regulatory Services 4700 River Road USDA, APHIS Riverdale, MD 20737 Fax: (301) 734-6352 The U.S. Department of Agriculture (USDA) prohibits discrimination in all its programs and activities on the basis of race, color, national origin, sex, religion, age, disability, political beliefs, sexual orientation, or marital or family status. (Not all prohibited bases apply to all programs.) Persons with disabilities who require alternative means for communication of program information (Braille, large print, audiotape, etc.) should contact USDA’S TARGET Center at (202) 720–2600 (voice and TDD). To file a complaint of discrimination, write USDA, Director, Office of Civil Rights, Room 326–W, Whitten Building, 1400 Independence Avenue, SW, Washington, DC 20250–9410 or call (202) 720–5964 (voice and TDD). USDA is an equal opportunity provider and employer. Mention of companies or commercial products in this report does not imply recommendation or endorsement by the U.S. Department of Agriculture over others not mentioned. USDA neither guarantees nor warrants the standard of any product mentioned. Product names are mentioned solely to report factually on available data and to provide specific information. This publication reports research involving pesticides. All uses of pesticides must be registered by appropriate State and/or Federal agencies before they can be recommended. CAUTION: Pesticides can be injurious to humans, domestic animals, desirable plants, and fish and other wildlife—if they are not handled or applied properly. -
History of Seed in the U.S. the Untold American Revolution 660 Pennsylvania Ave SE Suite 302 Washington, D.C
History of Seed in the U.S. The Untold American Revolution 660 Pennsylvania Ave SE Suite 302 Washington, D.C. 20003 P (202) 547-9359 F (202) 547-9429 www.centerforfoodsafety.org Save Our Seeds An exhibition at the National Archives in Washington, D.C., What’s Cooking Uncle Sam?, traces the history of U.S. agriculture from “the horse and plow (SOS) to today’s mechanized farm.” While the exhibition contains humorous elements, including a corporate campaign to win the War Food A program of the Administration’s endorsement of its Vitamin Donuts—“For pep and vigor… Center for Food Safety Vitamin Donuts!”—it also chronicles a sobering story of American farming and how the effects of U.S. food and agricultural policies reach far beyond the borders of Uncle Sam. Throughout, it is clear that the path of agriculture begins with the seed. Over the past 40 years, the U.S. has led a radical shift toward commercialization, consolidation, and control of seed. Prior to the advent of industrial agriculture, there were thousands of seed companies and public breeding institutions. At present, the top 10 seed and chemical companies, with the majority stake owned by U.S. corporations, control 73 1 Debbie Barker percent of the global market. International Program Today, fewer than 2 percent of Americans are farmers,2 whereas 90 percent 3 Director of our citizens lived on farms in 1810. This represents perhaps a more transformative revolution than even the Revolutionary War recorded in our history books. August 2012 This report will provide a summary of U.S. -
Congener Patterns of Polychlorinated Dibenzo-P-Dioxins
Science of the Total Environment 746 (2020) 141098 Contents lists available at ScienceDirect Science of the Total Environment journal homepage: www.elsevier.com/locate/scitotenv Review Congener patterns of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls as a useful aid to source identification during a contamination incident in the food chain Ron L.A.P. Hoogenboom a,⁎, Rainer Malisch b, Stefan P.J. van Leeuwen a, Huig Vanderperren c, Helge Hove d, Alwyn Fernandes f, Alexander Schächtele b, Martin Rose e,g a Wageningen Food Safety Research, Wageningen UR, Akkermaalsbos 2, 6708 WB Wageningen, the Netherlands b EURL for POPs, CVUA, Bissierstraße 5, 79114 Freiburg, Germany c FLVV, Leuvensesteenweg 17, 3080 Tervuren, Belgium d NIFES, Strandgaten 229, 5004 Bergen, Norway e FERA Science Ltd, Sand Hutton, York YO41 1LZ, UK f School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK g Manchester Institute of Biotechnology, University of Manchester, Manchester, UK HIGHLIGHTS GRAPHICAL ABSTRACT • Congener patterns are important tools for source identification. • TEQ contribution may be preferred over contribution to total sum. • Only PCDDs point to clay or chlorophenols, only PCDFs to PCB sources. • Mixed patterns point to minerals or burning processes. • Simple patterns indicate certain pesti- cides or herbicides. article info abstract Article history: Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) are still consid- Received 7 May 2020 ered among the most important groups of contaminants in the food chain. Self-control by food producers Received in revised form 13 July 2020 and official control by authorities are important activities that allow contaminant sources to be traced Accepted 18 July 2020 and promote further reduction in food and feed levels. -
U.S. EPA, Pesticide Product Label, MON 863 X MON 810, 10/10/2008
lv/ro 12-D9~ _, l UNITEO: ATES ENVIRONMENTJ&4;f,,\/ECTION c. _::NCY· i OCT 1 P 2008. Ms. Margaret Wideman Regulatory Affairs Manager Monsanto Company 800 North Lindbergh Blvd St.· Louis, MO 63167 Dear Ms. Wideman: Subject: Your February 15,2008 Amendment Requests to Remove the Expiration Dates for Yie1dGard, Yie1dGard Plus Com, and MON 88017 x -MONB 810 EPA Registration Nos. 524-489, 524-545, and 524-552 The amendments referred to above, .submitted in connection with registration under section 3(c)(7)(A)ofthe Federal Insecticide, Fungicide, and Rodenticide Act, as amended, are acceptable subject to the following comments. 1) For EPA Registration Numbers 524-489,~52*5~r5, and 524-552: ~) The subject plant-incorporated protectant may be combined through conventional breeding with other registered plant-incorporated protectants. that are similarly approved for use in combination, through conventional breeding, with other plant-incorporated protectants to produce inbred com lines and hybrid com varieties with combined pesticidal traits. b) The subject registration will automatically expire on midnight September 30,2010. We are currently unaware of any issues that would preclude a decision to remove the expiration date in the future.. However, due to other statutory priorities, BPPD's review. of the data and information submitted as conditions of registration is ongoing. Therefore, the expiration date is being extended to match that of com rootworm resistant Bt com as an interim measure. c) Refuge requirements do not apply to seed propagation of inbred and hybrid com seed com up to a total of 20,000 acres per county and up to a combined U.S. -
Environmental Health Criteria 39 PARAQUAT and DIQUAT
Environmental Health Criteria 39 PARAQUAT AND DIQUAT Please note that the layout and pagination of this web version are not identical with the printed version. Paraquat and diquat (EHC 39, 1984) INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY ENVIRONMENTAL HEALTH CRITERIA 39 PARAQUAT AND DIQUAT This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the United Nations Environment Programme, the International Labour Organisation, or the World Health Organization. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization World Health Orgnization Geneva, 1984 The International Programme on Chemical Safety (IPCS) is a joint venture of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. ISBN 92 4 154099 4 The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. Applications and enquiries should be addressed to the Office of Publications, World Health Organization, Geneva, Switzerland, which will be glad to provide the latest information on any changes made to the text, plans for new editions, and reprints and translations already available. -
The United States' Chemical Defoliant Use During the Vietnam War and Its
ABSTRACT OATSVALL, NEIL SHAFER. War on Nature, War on Bodies: The United States’ Chemical Defoliant Use During the Vietnam War and Its Consequences. (Under the direction of Matthew Morse Booker.) During most of the Vietnam War, from 1961-1971, the United States military sprayed chemical defoliants on a significant part of the Vietnamese environment in order to gain a military advantage. US forces used these chemicals in an attempt to substitute technology and financial resources for manpower to triumph over a relatively technologically deficient enemy. This effort, dubbed “Operation Ranch Hand,” wrought incredible destruction not only on Vietnam’s natural setting, but also on everyone involved; Vietnamese and American, civilian and soldier. This work examines the consequences of defoliation, and aims to show that those outcomes proved more severe in both scale and efficacy than any anticipated results. It differs from previous studies by combining environmental, military, medical, and cultural factors and considering them as interrelated. Whenever possible this study also tries to bring in a Vietnamese perspective, though that is often impossible due to a lack of available evidence in English. In this war, the United States treated not only the Vietnamese Communists as enemies but also assaulted the natural environment as foe. The interconnections forged during this complicated interpretation of nature and enemy are essential to the study of Operation Ranch Hand and chemical defoliation operations. Nature mattered to both sides, and an -
Federal Register/Vol. 75, No. 164/Wednesday, August 25, 2010
Federal Register / Vol. 75, No. 164 / Wednesday, August 25, 2010 / Notices 52329 Those persons who are or, may be Dated: August 17, 2010. FOR FURTHER INFORMATION CONTACT: required to conduct testing of chemical Jay S. Ellenberger, Jeannine Kausch, Biopesticides and substances under the Federal Food, Acting Director, Field and External Affairs Pollution Prevention Division (7511P), Drug, and Cosmetics Act (FFDCA), or Division, Office of Pesticide Programs. Office of Pesticide Programs, the Federal Insecticide, Fungicide, and [FR Doc. 2010–20842 Filed 8–24–10; 8:45 a.m.] Environmental Protection Agency, 1200 Rodenticide Act (FIFRA). BILLING CODE 6560–50–S Pennsylvania Ave., NW., Washington, DC 20460–0001; telephone number: B. How Can I Get Copies of this (703) 347–8920; fax number: (703) 305– Document and Other Related ENVIRONMENTAL PROTECTION 0118; e-mail address: Information? AGENCY [email protected]. 1. Docket. EPA has established a SUPPLEMENTARY INFORMATION: docket for this action under docket ID [EPA–HQ–OPP–2010–0699; FRL–8842–8] number EPA–HQ–OPP–2010–0001. I. General Information Corn Event MON 863 and MON 863 x Publicly available docket materials are MON 810; Product Cancellation Order A. Does this Action Apply to Me? available either in the electronic docket for Certain Pesticide Registrations at http://www.regulations.gov, or, if only This action is directed to the public in general, and may be of interest to a available in hard copy, at the Office of AGENCY: Environmental Protection wide range of stakeholders including Pesticide Programs (OPP) Regulatory Agency (EPA). environmental, human health, and Public Docket in Rm.