Anti-MS4A1 Monoclonal Antibody, Clone 3I8 [Biotin] (CABT-BL8096) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-MS4A1 Monoclonal antibody, clone 3I8 [Biotin] (CABT-BL8096) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Isotype IgG2b, κ

Source/Host Mouse

Species Reactivity Human

Clone 3I8

Purification Affinity chromatography

Conjugate Biotin

Applications FC, IHC, IHC-F

Format Liquid

Concentration 0.5 mg/mL

Size 25 ug;100 ug

Buffer PBS, pH 7.2, with 0.1% gelatin

Preservative 0.09% Sodium Azide

Storage 4°C, store in dark, DO NOT FREEZE!

BACKGROUND

Introduction CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

Keywords MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B- lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;

GENE INFORMATION

Entrez Gene ID 931

UniProt ID P11836

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