Vitae ISSN: 0121-4004
[email protected] Universidad de Antioquia Colombia QUIJANO P., Silvia; NOTARIO B., Rafael; QUIJANO T., Jairo; RAMÍREZ A., Luz A.; VÉLEZ O., Ederley; GIL G., Maritza A. THEORETICAL STUDY OF THE MALONDIALDEHYDE-ADDUCTS FORMED BY REACTION WITH DNA-BASES Vitae, vol. 11, núm. 1, 2004, pp. 5-12 Universidad de Antioquia Medellín, Colombia Available in: http://www.redalyc.org/articulo.oa?id=169818259002 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative 5 VITAE, REVISTA DE LA FACULTAD DE QUÍMICA FARMACÉUTICA ISSN 0121-4004 Volumen 11 número 1, año 2004. Universidad de Antioquia, Medellín - Colombia. págs. 5-12 THEORETICAL STUDY OF THE MALONDIALDEHYDE- ADDUCTS FORMED BY REACTION WITH DNA-BASES ESTUDIO TEÓRICO DE LOS ADUCTOS-MALONDIALDEHÍDO FORMADOS POR LA REACCIÓN CON BASES ADN Silvia QUIJANO P.,1* Rafael NOTARIO B.,2 Jairo QUIJANO T.,3 Luz A. RAMÍREZ A.,3 Ederley VÉLEZ O.3 y Maritza A. GIL G.3 ABSTRACT Malondialdehyde (MDA) is a major genotoxic carbonyl compound generated by lipid peroxidation and is also a by-product of the arachidonic acid metabolism in the synthesis of prostaglandins. MDA has been shown to be mutagenic in bacterial and mammalian systems and carcinogenic in rodents. Besides, it is known that MDA reacts with DNA to form adducts with deoxyguanosine, dG, deoxyadenosine, dA, and deoxycytidine, dC: M1G, M1A and M1C, respectively. In this paper we present a density functional theoretical study of the several nucleophilic additions followed by eliminations of MDA with dG, dA, and dC.