EXOCRINE GLANDS

Exocrine Glands

Proceedings of a Satellite Symposium of the XXIV International Congress of Physiological Sciences

EDITORS:

STELLA Y. BOTELHO, M.D. FRANK P. BROOKS, M.D. WALTER B. SHELLEY, M.D., PHD.

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UNIVERSITY OF PENNSYLVANIA PRESS PHILADELPHIA 1969 Printed 1969 by the University of Pennsylvania Press. Copyright under the International Copyright Union. All rights reserved. This book is protected by copyright. No part of it may be duplicated or reproduced in any manner without written permission from the publisher. Made in the United States of America. University of Pennsylvania Press. Library of Congress catalogue number 72-97070 SBN: 8122-7606-X Printed in the United States Participants

ANNE M. ABROMOVAGE, Hahnemann Medical College, Philadelphia, Pa. MARIO ALTAMIRANO, Universidad Central de Venezuela, Caracas, Venezuela JOHN E. BAER, Merck Institute for Therapeutic Research, West Point, Pa. F. K. BAGATELL, Squibb Institute for Medical Research, New Bruns- wick, N.J. HAROLD M. BATES, Wallace Laboratories, Cranbury, N.J. LYLE V. BECK, Indiana University, Bloomington, Indiana HERMAN BEERMAN, University of Pennsylvania ROBERT W. BERLINER, National Heart Institute, Bethesda, Maryland JOHN BIENENSTOCK, McMaster University, Hamilton, Ontario, Canada THOMAS F. BOAT, National Institute of Health, Bethesda, Maryland STELLA Y. BOTELHO, University of Pennsylvania G. E. BRIGHTENBACK, Merck Sharp and Dohme Research Laboratories, Rah way, N.J. FRANK P. BROOKS, University of Pennsylvania WILLIAM J. BRUNTON, University of Pennsylvania SAUL W. BRUSILOW, Johns Hopkins University, Baltimore, Maryland A. S. V. BURGEN, Cambridge University, Cambridge, England CLYDE BURNETT, Revlon Incorporated, New York, New York R. M. CASE, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, England MICHAEL CHANG, Brandeis University, Waltham, Massachusetts HOWARD H. CHAUNCEY, Veterans Administration Central Office, Wash- ington, D.C. MICHAEL CLARK, Philadelphia General Hospital, Philadelphia, Pa. C. DAWES, University of Manitoba, Winnipeg, Manitoba, Canada ANA DEPALAU, University of Panama, Republic of Panama E. C. DERENZO, Lederle Laboratories Division, Pearl River, New York S. J. DESALVA, Colgate Research Center, Piscataway, New Jersey RICHARD L. DOBSON, University of Oregon, Portland, Oregon

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DONALD S. DOUGLAS, George Washington University, Washington, D.C. WILLIAM A. DUNSON, Pennsylvania State University, University Park, Pa. HENRY EDINGER, University of Pennsylvania PATRICIA EGGENA, Mount Sinai School of Medicine, New York, New York W. B. ELVERS, New York, New York NILS EMMELIN, University of Lund, Lund, Sweden RALPH P. FELLER, Veterans Administration Hospital, Boston, Massa- chusetts MICHAEL E. FRITZ, Emory University, Atlanta, Georgia NILIO E. FUENMAYOR, University of Zulia, Maracaibo, Venezuela J. R. GARRETT, Kings College Hospital, London, England ARTHUR GOLDSTEIN, University of Pennsylvania CARL A. GORESKY, Montreal General Hospital, Montreal, Quebec, Canada RICHARD J. GRAND, Massachusetts Institute of Technology, Cambridge, Mass. H. DAVID HALL, Vanderbilt University, Nashville, Tennessee A. A. HARPER, University of Newcastle-upon-Tyne, Newcastle-upon- Tyne, England BASIL L. HENRIQUES, Boston University, Boston, Massachusetts JOHN F. HERNDON, National Cystic Fibrosis Research Foundation, New York, N.Y. N. C. HIGHTOWER, Scott and White Clinic, Temple, Texas MABEL R. HOKIN, University of Wisconsin, Madison, Wisconsin KENNETH R. HOLDEN, Smith, Kline and French Laboratories, Philadel- phia, Pa. JOSEPH H. HOLMES, University of Colorado, Denver, Colorado MARTIN HOROWITZ, New York Medical College, New York, New York ALBERTO B. HOUSSAY, Universidad de Buenos Aires, Buenos Aires, Argentina DUNCAN HUTCHEON, New Jersey College of Medicine and Dentistry, Jersey City, New Jersey KIMIO IKAI, Johns Hopkins University, Baltimore, Maryland HENRY I. JACOBY, Merck Sharp and Dohme Research Laboratories, West Point, Pa. HENRY D. JANOWITZ, Mount Sinai School of Medicine, New York, New York Participants / vii

GRAHAM JEFFRIES, College of Medicine, Milton S. Hershey Medicai Center, Pennsylvania State University, Hershey Pennsylvania. DAVID MCEWAN JENKINSON, Hannah Dairy Research Institute, Ayr, Scotland ROBERT E. JOHNSON, University of Illinois, Urbana, Illinois KRONIS KAPUR, Cleveland, Ohio KON-TAIL KHAW, Children's Hospital Medicai Center, Boston, Massa- chusetts LEON KRAINTZ, University of British Columbia, Vancouver, B.C., Canada F. KREUTZER, Catholic University, Nijmegen, Netherlands KARL LADEN, Gillette Research Institute, Washington, D.C. BERNARD R. LANDAU, Merck Institute for Therapeutic Research, Rahway, N.J. BEN MARR LANMAN, Bristol-Myers Products, New York, New York A. K. LASCELLES, Institute of Animal Physiology, Babraham, Cam- bridge, England ARNOLD LIEBERMAN, New York, New York NATHAN LIFSON, University of Minnesota, Minneapolis, Minnesota T. M. LIN, Lilly Research Laboratories, Indianapolis, Indiana J. L. LINZELL, Institute of Animal Physiology, Babraham, Cambridge, England CHARLES C. LOBECK, University of Wisconsin, Madison, Wisconsin JAMES F. LONG, Albany Medical College, Albany, New York W. L. LUEDDERS, The Proctor and Gamble Company, Cincinnati, Ohio DONAL F. MAGEE, Creighton University, Omaha, Nebraska FRANK MARCHESE, Revlon Incorporated, New York, New York J. RICARDO MARTINEZ, University of El Salvador, San Salvador, El Salvador MAURICE W. MEYER, University of Minnesota, Minneapolis, Minnesota MARTIN C. MIHM, JR., USPHS Hospital, Staten Island, New York GLENN E. MORTIMORE, Milton S. Hershey Medical Center, Hershey, Pa. INGRITH DEYRUP-OLSEN, University of Washington, Seattle, Washington J. CHARLES PALLAVICINI, National Institutes of Health, Bethesda, Maryland LARRY PALMER, University of Pennsylvania FREDERICK M. PARKINS, University of Pennsylvania G. PEETERS, University of Ghent, Ghent, Belgium OLE HOLGER PETERSEN, University of Copenhagen, Copenhagen, Den- mark viii / Participants

F. PLOEGMAKERS, Catholic University, Nijmegen, Netherlands JORGEN HEDEMARK POULSEN, University of Copenhagen, Copenhagen, Denmark R. M. PRESHAW, Mayo Clinic, Rochester, Minnesota RICHARD P. QUATRALE, Gillette Research Institute, Washington, D.C. HOWARD REBER, University of Pennsylvania M. T. RIBERA, Hospital Santa Cruz y San Pablo, Barcelona, Spain PETER T. RIDLEY, Smith, Kline and French Laboratories, Philadelphia, Pa. GERALD I. ROTH, University of Pennsylvania STEPHEN S. ROTHMAN, Harvard Medical School, Boston, Massachusetts KENZO SATO, University of Oregon, Portland, Oregon HERBERT SCHAPIRO, University of Tennessee, Memphis, Tennessee CHARLOTTE SCHNEYER, University of Alabama, Birmingham, Alabama LEON H. SCHNEYER, University of Alabama, Birmingham, Alabama IRENE SCHULZ, Max-Planck-Institut fur Biophysik, Frankfurt, Germany IRVING L. SCHWARTZ, Mount Sinai School of Medicine, New York, New York THOMAS SCRATCHERD, University of Newcastle-upon-Tyne, Newcastle- upon-Tyne, England ERNEST S. SEARS, JR., University of Texas, Dallas, Texas ALBERT W. SEDAR, Jefferson Medical College, Philadelphia, Pa. PAULETTE SETTLER, University of Pennsylvania IRA L. SHANNON, Veterans Administration Hospital, Houston, Texas WALTER B. SHELLEY, University of Pennsylvania J. F. G. SLEGERS, Catholic University, Nijmegen, Netherlands EDWIN L. SMITH, University of Texas, Houston, Texas LEIF SOLBERG, University of Pennsylvania ROGER D. SOLOWAY, University of Pennsylvania ISAAC STARR, University of Pennsylvania RICHARD P. SUDDICK, Creighton University, Omaha, Nebraska RICHARD TAYLOR, University of Oregon, Portland, Oregon E. CLINTON TEXTER, JR., Scott and White Clinic, Temple, Texas NIELS A. THORN, University of Copenhagen, Copenhagen, Denmark PHILIP TOSKES, University of Pennsylvania H. C. VANPROOYEN, Catholic University, Nijmegen, Netherlands MORTON B. WAITZMAN, Emory University, Atlanta, Georgia JOE R. WARDELL, JR., Smith, Kline and French Laboratories, Philadel- phia, Pa. Participants / ix

GEORGE D. WEBSTER, University of Pennsylvania PAUL D. WEBSTER, Medicai College of Georgia, Augusta, Georgia ANN WECHSLER, McGill University, Montreal, Quebec, Canada JOHN I. WHITE, Baltimore College of Dental Surgery, Baltimore, Mary- land VIRGIL WIEBELHAUS, Smith, Kline and French Laboratories, Philadel- phia, Pa. ULRICH WIESMANN, National Institutes of Health, Bethesda, Maryland J. H. WILLS, Albany Medical College, Albany, New York JOSEPH A. WITKOWSKI, University of Pennsylvania EURIPIDES YIACAS, Squibb Institute for Medical Research, New Bruns- wich, N.J.