Annual Report 2016–2017

ANNUAL REPORT 2016/17 A Cover image: Anna Kobylianskii, OBGYN Resident Design: Green Living Enterprises Printing: Flash Reproductions

B UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY TABLE OF CONTENTS

2 ORGANIZATIONAL STRUCTURE 43 CHAIR’S CREMS STUDENTS & SUMMER STUDENTSHIP AWARDS 3 MISSION STATEMENT CREMS Students Summer Students 4 MESSAGE FROM THE CHAIR 53 EVENTS, SIGNIFICANT 7 OUR PEOPLE: FACULTY, STAFF, HONOURS & AWARDS & TRAINEES 2016–2017 34th Annual Research Day Primary Appointments Faculty Professional Development Day 2016 Cross Appointments Graduation Ceremony & Alumni Event Administrative Staff Significant Honours & Awards Residents Clinical Fellows 69 RESEARCH GRANTS & Committees INVESTIGATIONS Peer-reviewed Grants 15 HOSPITAL STATISTICS 77 PEER-REVIEWED PUBLICATIONS 17 DIVISION REPORTS Original Research Core Obstetrics & Gynaecology Clinical Practice Guidelines Gynaecologic Oncology Books & Book Chapters Maternal-fetal Medicine Reproductive Endocrinology & Infertility 91 INVITED LECTURES & Paediatric & Adolescent Gynaecology VISITING PROFESSORSHIPS Urogynaecology International Lectures National Lectures 29 PROGRAM REPORTS Local Lectures Undergraduate Medical Education Residency Training Program 105 PRESENTATIONS Fellowship Training Programs International Abstract Presentations Continuing Medical Education National Abstract Presentations Global Health and Advocacy Local Abstract Presentations

39 COMMITTEE REPORTS 124 COMMON ABBREVIATIONS Promotions & Awards Committee Research Committee

ANNUAL REPORT 2016/17 1 ORGANIZATIONAL STRUCTURE

John Kingdom Department Chair

Gareth Seaward Rachel Spitzer Vice Chair, Quality Vice Chair, Global Improvement & Patient Women’s Health & Safety (QIPS) Advocacy

Heather Shapiro Kellie Murphy Vice Chair, Vice Chair, Research Education

Education Administration Research Divisions

Mark Yudin Filomena Meffe Nelson Cabral Director, Clinical Arthur Zaltz Faculty Development Business Manager Research Core OBGYN

Rajiv Shah Jeannette Moniz Theodore Brown Allan Covens Program Director, Undergraduate Department Deputy Chair, Gynaecologic Undergraduate Program Coordinator Executive Assistant Research Committee Oncology (GynOnc) Education

Michele Farrugia Caroline Sutherland Kristen Gane Theodore Brown Residency Program Residency Program Academic Reproductive Director Coordinator Appointments Endocrinology & Assistant Infertility (REI)

Rory Windrim Lisa Allen Continuing Joseph George Paediatric & Professional Fellowship Adolescent Development Coordinator Gynaecology (PAG)

Nanette Okun Maternal-Fetal Medicine (MFM)

Patricia Lee Urogynaecology

2 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY MISSION STATEMENT

Our Mission Our mission is to generate game-changing research, The Department would like to thank the improve standards of care, advance public policy, following individuals for their contributions and prepare the physicians and leaders of tomorrow to the creation of this report: in ways that transform the health of women locally, nationally and around the world. • Nelson Cabral • Jeannette Moniz Our Vision • Caroline Sutherland As a unified department, we aim to develop, • Kristen Gane fully leverage and integrate ground-breaking • Joseph George research, knowledge and practice in obstetrics • Ashley Lanys and gynaecology from across our extensive • Michael Browne network to transform women’s health locally, nationally and around the world.

ANNUAL REPORT 2016/17 3 MESSAGE FROM THE CHAIR

Faculty Professional Development Day at Vaughan WELCOME to our 2016-2017 Annual Estates on November 11, 2016. Our guest speakers Report prepared by our Communications were Dr. Brian Murray, who spoke about “Sleep: Specialist, Michael Browne. This is the 4th Your Health and Clinical Practice” and Dr. Karen report from me as Chair. Each forms the Leslie, who spoke about how to ensure that academic careers are both successful and fulfilling. The basis for our Self-Study report, covering the theme for the day was exploring topics on faculty 5-year period 2012–2017, in advance of our mentorship and wellness. The day concluded with External Review, February 26–27, 2018. our awards ceremony, where yet again, many talented individuals across all our hospital sites were recognized for their outstanding contributions. Continuing our tradition of celebrating our trainees, This year’s recipients of our Education and Research our report showcases our expanding summer student Awards and our Undergraduate and Postgraduate program, guided by our Research Committee. Teaching Awards are listed in this report at page 66. This year we had 8 University of Toronto medical We have continued to formally celebrate our students participate in the CREMS Summer Student faculty members who were successful with their Research program, with an additional 11 students Senior Promotions, effective July 1st, 2017. Dr. supported via the Chair’s Summer Student program. Ellen Greenblatt was promoted to full Professor. You can read about their projects in this report at Consequently in the past 4 years, 6 out of 7 of our pages 43–52. newly-minted full professors have been women, sending an important signal of encouragement to Thanks to the leadership of Filomena Meffe and her our trainees and junior faculty members. team, we had a very successful and well-attended

4 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY MESSAGE FROM THE CHAIR

In December 2016, Dr. Donna Steele received our completion of one or more years of clinical Department’s APOG Carl Nimrod Educator of the fellowship training. At the evening, Dr. Alan Year Award. Bocking also gave a wonderful expression of thanks to Dr. Donna Steele, who was a fantastic residency Research Day in May 2017 was yet another great program director for the period 2012–2017. She is success, with over 100 abstracts and over 300 followed by Dr. Michele Farrugia. attendees. My deep thanks to Nelson Cabral, the administration team, and hospital administrators Our 2018 Alumni and Graduation event will also and volunteers, for their superb contribution to the be held at Hart House on June 14th. This event will smooth execution of this event which remains a be made special by the presentation and launch of highlight in our year. Special thanks go to our Vice our publication documenting the 175-year history of Chair, Research, Kellie Murphy, and her committee, the Department of Obstetrics & Gynaecology at the especially to Ted Brown and Mark Yudin, who University of Toronto. I do hope that you will mark together with our administration team orchestrated your calendars to come to this event, concluding my a world-class event, scientifically on par with any initial 5-year appointment as Department Chair. international meeting. Dr. Dorothy Shaw from the University of British Columbia was our Henderson I would like to briefly focus on and thank our Lecturer with the title, “How Evidence Informs excellent administration team here at 123 Edward Advocacy for Women’s Health: A Lifelong Journey.” Street, led by our Business Officer, Nelson Cabral. As of summer 2016, we welcomed Ms. Ashley Lanys The Department continues to support the key to focus on supporting our Global Health initiatives transition from senior trainee to junior faculty under the direction of Dr. Rachel Spitzer. position in their first 3–4 years. Each award provides support in the form of protected academic time. Each of our 5 areas of focus identified in our strategic This past academic year, we awarded Dr. Stefania plan 2014–2019 continues to develop. This year, our Ronzoni, a new faculty member at Sunnybrook Global Women’s Health program at Moi University, Health Sciences Centre, with a Junior Faculty Award in Eldoret, Kenya, celebrates its 10th anniversary for three years. under the direction of our Vice Chair in Global Women’s Health and Advocacy, Dr. Rachel Spitzer In June 2017, we concluded our academic year with in partnership with our field director, Dr. Astrid our annual Graduation and Alumni Event. This time Christoffersen-Deb. In June 2017, I am pleased to we had over 260 graduates, their families, and faculty report that the Kimel Foundation generously agreed members in attendance. Many thanks to our past- to extend their support for a further 4 years, allowing Chair, Dr. Alan Bocking, for his thoughtful address us to equally support our efforts to provide sub- to the graduates. We were delighted that one of our specialty training in both Gynaecologic Oncology oldest residency training program graduates, Dr. Bill and in Maternal-Fetal Medicine. You can read Whittaker (graduated 1959), was in attendance with more about this expanding connection between our his daughter, and came to the microphone to share a university and Kenya on pages 37–38 and on our few words of wisdom. website. We actively encourage faculty members to consider contributing to this valued program. This summer a total of 13 trainees completed their PGY5 year, transitioning to specialists in Obstetrics I would also like to congratulate the following & Gynaecology. They were accompanied by an individuals who received their faculty appointment additional 27 sub-specialists, graduating following in the 2016–2017 academic year:

ANNUAL REPORT 2016/17 5 Message from the Chair

New Faculty Dr. Robert Casper, former Head of the Division of Appointments 16-17 Reproductive Endocrinology and Infertility (REI) • Odueke Adebayo at Toronto General and Mount Sinai Hospitals • Kayode Ayodele until 2003, became Emeritus Professor on July • Allison Ball 1st, 2017. Bob is an internationally renowned and • Karima Benomran highly innovative REI academic. Bob went on to • Genevieve establish the TCART REI facility, together with Bouchard-Fortier his clinical fellowship in Reproductive Sciences, • Nirmala and continued his research career as a Scientist at Chandrasekaran the Lunenfeld Tanenbaum Research Institute at • Paul Davies Mount Sinai Hospital. In 2014, TCART merged • Helena Frecker with LifeQuest to form TRIO where his fellowship • Eve Fried training program will continue until June 30th, • Sheldon Girvitz 2019. We thank Bob for distinguishing our • Karen Gronau Department at the national and international levels • Liat Hogen over many years. Our strong REI Division today • Tianhua Huang owes much to his talented contributions. • Susan Jia • Leah Jutzi I hope you enjoy the various sections of this • Quynh Le report. Our next communications will be our • Nucelio Lemos 5-year self study report, followed then by the • Leslie Po launch of our 175-year history in June 2018. As • Katherine Pulman this major anniversary approaches for Canada’s • Jean-Placide largest and premier Department, I sign off with my Rababaza sincere thanks to you all, for your commitments • Monique Rose to excellent patient care, your countless hours of Rahmani student and resident instruction, and your efforts • Stefania Ronzoni to deliver impactful research. • Priya Sharma • Samuel Soliman Best wishes, • Prema Vaidyanathan • Laura White

John C.P. Kingdom, M.D. Gordon C. Leitch Chair Department of Obstetrics & Gynaecology

6 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Our People: Faculty, Staff, & Trainees 2016 –2017

ANNUAL REPORT 2016/17 7 PRIMARY APPOINTMENTS

Nir Melamed L. Ray Osborne** Richard Pittini Ian Rogers Stefania Ronzoni* Heather Shapiro M. Jonathan Solnik Rachel Spitzer Michael Sved Artin Ternamian Paul Thistle Tim Van Mieghem Suzanne Wong Mark Yudin Arthur Zaltz

Assistant Professors Hani Akoury Rebecca Arthur** Oluleke Badmos Allison Ball* * New Appointment | ** New Promotion | ~ Left the department Dec 31st Marshall Barkin Yaakov Bentov Professors Emeriti Jennifer Blake Associate Anne Berndl S. Lee Adamson Theodore J. Brown Professors Dalip K. Bhangu Alan D. Bocking Isabella Caniggia May Alarab Genevieve Bouchard- Rudi Borth Allan L. Covens Howard Berger Fortier* Robert F. Casper Dan Farine Marcus Bernardini Nicolette Caccia AD (Denny) De Petrillo Michael Geary Janet Bodley Kenneth Cadesky Terence Doran John Kingdom, Chair Adrian Brown Crystal Chan Douglas J. Gare Stephen Lye Christine Derzko Astrid Christoffersen-Deb Mary E. Hannah K. Joan Murphy Sarah Ferguson Dennis K. Chu Walter J. Hannah Kellie E. Murphy** Alan Gerulath E. Anne Claessens Gordon M. Lickrish Andras Nagy Lilian Gien** Howard Cohen Ron A. Livingstone Nanette Okun** James Goodwin Barbara Cruickshank JE (Ted) Morgan Craig Pennell Ellen Greenblatt Marie Czikk Jerry Shime Felice Petraglia Elaine Herer Rohan D’Souza J.W. Knox Ritchie Andrea Jurisicova Marjorie Dixon Associate Barry Rosen Sari Kives Jason Dodge Professors Emeriti Greg Ryan Rose Kung Xuesen Dong Nancy Durand Titus Owolabi Gareth R Seaward Nucelio Lemos* Mathew Sermer Clifford L Librach William A. Easton Professors R. Michael Shier Kay Lie Frederic A. Engle Rory Windrim Michele Farrugia Lisa Allen** Danny Lovatsis Wendy Wolfman Tomer Feigenberg Jon Barrett Cynthia Maxwell Helena Frecker* Paul Bernstein Filomena Meffe

8 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY PRIMARY APPOINTMENTS

Tatiana Freire-Lizama Prati Sharma Jennifer Cram Haidar Mahmoud Karen Glass Lindsay Shirreff Joseph Cramer Erica Mantay Mathias Gysler Eliane Shore Lanval (Joe) Daly Siobhan Mark Peter Hawrylyshyn Oksana Shynlova Paul Davies* Mary Melchior Man Fan Ho Sony Sierra Kristina Dervaitis Heather Millar Liat Hogen* Mara Sobel Karthika Devarajan Kerry Myckan Tianhua Huang* Dana Soroka Phaedra Diamond Alexandra Nevin Lam Dini Hui Donna Steele Anthony Di Kendra Newell Stephen Im Wilf Steinberg Pierdomenico Andrea Page Clarie Jones Karen Tessler Patricia Doyle Esther Park Johannes Keunen Bruce W. Thomas Marianne R. Duemler Carol Peng Yolanda A. Kirkham Jackie Thomas May ElHajj Perry Phillips Murray Kroach Modupe Tunde-Byass Eve Fried* Jing Qin Jamie Kroft Danielle Vicus Louise-Hélène Gagnon Jean-Placide Rababaza* Rachel Kupets Fay Weisberg Maja Gans Elin Raymond Elyse Lackie Wendy Whittle Dimitrios Giannoulias Kimberly Rogers Noor Ladhani Georgina Wilcock** Sheldon Girvitz* Monique Rose Rahmani* Stephane Laframboise Herb Wong Gwendolyn Goodrow Edward Ryan Andrea Lausman Brenda T. Woods Karen Gronau* Abheha Satkunaratnam Patricia Lee Beata Grygowski Jan Scheeres Elyse Levinsky Lecturers Paul Gurland Peter W. Scheufler Grace Liu Odueke Adebayo* Ronnie Hakim Priya Sharma* Kimberly Liu Anjali Aggarwal Alice Han Nicholas Shilletto Ann Kinga Malinowski Ambika Aneja Helen Ho Paul Shuen Adelmo Martoglio George Arthur Salikah Iqbal Michael Silver Taymaa May Kayode Ayodele* Michelle Jacobson Sarah Sinasac Colleen McDermott Clarissa Bambao Susan Jia* Gita Singh Elad Mei-Dan Ari Baratz Sybil Judah Kirsten Smith Eva Mocarski Donna Barnwell Naana Jumah Samuel Soliman* Matthew Morton Karima Benomran* Leah Jutzi* Richard Stein Sergey Moskovtsev Veena Bonde Allan Kanee Linda Stirk Ally Murji Yoav Brill Angela Kang Shiraz Suleman Dan Nayot Melanie Caetano Jevan Ko Melissa Tai Ori Nevo David Caloia Samuel Ko* Scott Tigert Melanie Ornstein Shannon Causey Andrew Kotaska Prema Vaidyanathan* Wusun Paek Dora Chan Danny Kreichman Carol Wade Nicholas Pairaudeau Nirmala Chandrasekaran* Asha Kurup Anne Walsh Alice Pham Paul Chang Matthew Laskin Peter Watt Leslie Po* Mary M.L. Cheng Quynh Le* Laura White* Katherine Pulman* Nicole Cherry Sabrina Lee Jeremy C. Wong Deborah Robertson Kelly Chu Sylvie Leone-Tomaschoff Vincent Wu David Rosenthal Amanda Cipolla Patrick M. Liao Gonzalo Fernando Nathan Roth** Shannon Corbett Terry Logaridis Zevallos Amanda Selk Aleksandre Corbey Joanne Ma Lynne Zolis Rajiv Shah Stacy Lara Costa Roberta Mackenzie Jodi Shapiro Catherine Ann Cowal Tara MacLeod

ANNUAL REPORT 2016/17 9 CROSS APPOINTMENTS

Evelyn Lambe, Physiology Stephen Holzapfel, Family & Community Medicine Sarah Keating, Laboratory Medicine & Pathobiology Elena Kolomietz, Laboratory Medicine & Pathobiology Evelyn Lambe, Physiology Carl Laskin, Medicine Jose Sarrazin, Medical Imaging Michael Sgro, Paediatrics * New Appointment | ** New Promotion | ~ Left the department Dec 31st Candice Silversides, Medicine Professors Emeriti Jack Marc Colman, Gillian Thomas, Michelle Letarte, Medicine – Cardiology Radiation Oncology John Sled, Medical Biophysics Immunology Anthony W. Fyles, Ants Toi, Medical Imaging Rachel Wald, Paediatrics Terence Colgan*, Radiation Oncology Rosanna Weksberg, Laboratory Medicine & Stephen Halpern, Molecular Genetics Shui Eugene Yu, Pathobiology Anaesthesia Medical Imaging Kevin Kain, Medicine Associate Associate Mahmoud Khalifa, Professors Assistant Professors Emeriti Laboratory Medicine & Ida Ackerman, Professors Tony Barozzino, Sarah Keating*, Pathobiology Radiation Oncology Laboratory Medicine & Paediatrics Shoo Lee, Paediatrics Elizabeth Asztalos, Pathobiology Karen Chong, Paediatrics Stephen Matthews, Paediatrics Physiology Brian Cox, Physiology Professors Mrinalini Balki, Anesthesia Mike Seed, Paediatrics Denise Belsham, Steven Narod, Public Physiology Health Sciences Adalsteinn Brown, Martin Skidmore, Health Policy, Management Paediatrics José Carvalho, Anesthesia Amit Oza, Medicine & Evaluation Sandra Viero, Laboratory William B. Chapman, Joel Ray, Medicine Michael Dunn, Medicine & Pathobiology Laboratory Medicine & Gail Robinson, Paediatrics Pathobiology Psychiatry Denice Feig, David A. Chitayat, Patricia Shaw, Laboratory Lecturers Medicine Paediatrics Medicine & Pathobiology Fern Small, Psychiatry Katherine Fong, Terence Colgan, Sam Siu, Medicine Nina Venkatrangam, Medical Imaging Family & Community Laboratory Medicine & Donna Stewart, Phyllis Glanc, Medicine Pathobiology Psychiatry Medical Imaging

10 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY ADMINISTRATIVE STAFF

Nelson Cabral, Jeannette Caroline Kristen Gane, Joe George, Business Moniz, Sutherland, Academic Fellowship Manager Undergraduate Residency Appointments Programs Program Program Assistant Coordinator Coordinator Coordinator

RESIDENTS

Postgraduate Postgraduate Postgraduate Postgraduate Postgraduate Year 1 Year 2 Year 3 Year 4 Year 5 Kailyn Brandon Mohammad Albar Tamara Abraham Sophie Bussiere- Marie Christakis Sutherland Meghan Brown Laura Cancelliere Cote Lara Gotha Shirin Dason Michael Chaikof Rita Chuang Kristin Harris Lacey Harding Pavan Gill Rebecca Cherniak Maria Cusimano Lesley Hawkins John Ibrahim Shira Jaclyn Gold Humara Edell Darl Edwards Lauren Jain Ingrid Lai Kinshuk Kumar Vishaal Gupta Brittany Hoover Marian Leung Adrienne Li Stephanie Lapinsky Anjali Kulkarni Thomas Jordan Sonali Lokuge Mathew Leonardi Alisha Olsthoorn Siddhi Mathur Karen Levy Amanda Michael Carmen Sara Porisky Elizabeth Miazga Katherine McLean Andra Nica McCaffrey Emma Skolnik Sarah Norris Tumushabe Lauren Philp Chaula Mehta Jessica Smith Carolyn Reardon Mutungi Julie Nguyen Geoffrey Zeni Shabnam Sattari Leslie Proctor Kirsten Niles Khavas Neetika Sidana Rebecca Rich Brenna Swift Heather Sullivan Aparna Rebecca Zur Evan Tannenbaum Sarangapani Marina Vainder Lynn Sterling Melissa Walker Marta Wais Jellena Wong

ANNUAL REPORT 2016/17 11 CLINICAL FELLOWS COMMITTEES

* Royal College of Physicians and Surgeons of Canada accredited Executive Mathew Sermer, Chief, ** American Association of Gynaecologic Laparoscopists Committee Mount Sinai Hospital/ John Kingdom, Chair University Health Network/ Advanced High-Risk Minimally Invasive Women’s College Hospital Lisa Allen, Chair, Obstetrics Gynaecologic Surgery Promotions Committee Heather Shapiro, Director: Howard Berger (AAGL)** Head, Division of Vice Chair, Education Fellows: Yael Ganor, Director: Herb Wong Paediatric & Adolescent Rachel Spitzer, Dana Vitner Fellow: Brian Liu Gynaecology Vice Chair, Global Women’s Health Advanced Obstetrics Minimally Invasive Adrian Brown, Director: Dini Hui Gynaecologic Surgery Community Affiliate Donna Steele, Fellow: Maayan Bas-Londo Director: Deborah Robertson Hospital Representative; Chair, Residency Program Fellows: Grace Yeung, Chief, North York General Committee; Residency Gynaecologic Reproductive Aisha Yousuf Hospital Program Director Endocrinology & Infertility Ted Brown, Head, Rory Windrim, Director, (RCPSC)* Paediatric & Adolescent Division of Reproductive Continuing Professional Director: Kimberly Liu Gynaecology Endocrinology & Infertility; Development Fellows: Jason Elliott, Director: Sari Kives Deputy Chair, Research Mark Yudin, Chair, Tamas Gotz Fellow: Carol King Committee Research Committee; Michael Geary, Chief, Director, Clinical Research Gynaecologic Endoscopic Perinatal St. Michael’s Hospital Arthur Zaltz, Chief, Surgery Director: Cynthia Maxwell Patricia Lee, Interim Sunnybrook Health Director: Mary Melchior Fellows: Gharid Nourallah Head, Division of Sciences Centre; Chair, Fellow: Vicky Hadid Bekdache, Nili Isserles, Urogynaecology Department Appointments Gabrielle Cassir Committee Gynaecologic Oncology Kellie Murphy, (RCPSC)* Reproductive Sciences Vice Chair, Research Director: Stephane Director: Robert Casper Nanette Okun, Advocacy Commitee Rachel Spitzer, Chair Laframboise Fellows: Tzu-Bou Hsieh, Jigal Head, Division of Alan Bocking Fellow: Harinder Brar Haas, Genevieve Genest Maternal-Fetal Medicine Michele Farrugia Filomena Meffe, Director, Tatiana Freire-Lizama Maternal-Fetal Medicine Reproductive Sciences Faculty Development Clare Jones (RCPSC)* & Infertility Allan Covens, Elyse Lackie Director: Cynthia Maxwell Director: Clifford Librach Head, Division of Noor Ladhani Fellows: Nirmala Fellow: Khalid Zohni Gynaecologic Oncology Heather Millar Chandrasekaran, Shimrit Rajiv Shah, Nanette Okun Yaniv Salem, Yair Sagi, Urogynaecology & Chair, Undergraduate Melanie Ornstein Stefania Ronzoni, Reconstructive Pelvic Medical Education Rebecca Rich Hanan Alsehi, Rasheeda Surgery Committee; Director of Amanda Selk A l Tourshi Director: Danny Lovatsis Undergraduate Medical Emma Skolnik Fellow: Andrea Santiago Education Tiffany Zigras Mature Women’s Rebecca Zur Health & Menopause Global Women’s Health Gareth Seaward, Director: Wendy Wolfman and Equity Vice Chair, Quality Fellow: Lina Huang Director: Rachel Spitzer Improvement and Patient Fellow: Heather Millar Safety (QIPS)

12 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY COMMITTEES

Appointments Stephane Laframboise Julie Nguyen Andra Nica Commitee Patricia Lee Andrea Page Abheha Satkunaratnam Art Zaltz, Chair Clifford Librach Leslie Po Amanda Selk Lisa Allen Kimberly Liu Deborah Robertson Azra Shivji Theodore Brown Danny Lovatsis Nathan Roth Donna Steele Adrian Brown Cynthia Maxwell Abheha Satkunaratnam Mark Yudin Lilian Gien Mary Melchior Lynne Zolis Kellie Murphy Ally Murji Research Nathan Roth Deborah Robertson Committee Undergraduate Abheha Satkunaratnam Jonathon Solnik Mark Yudin, Chair Education Mathew Sermer Rachel Spitzer May Alarab Committee Heather Shapiro Wendy Whittle Theodore Brown Rajiv Shah, Chair Jonathan Solnik Wendy Wolfman Isabella Caniggia Ari Baratz Herb Wong Crystal Chan Avneet Bening Combined Continuing Kristin Connor Koo Chun Professional Promotions & Allan Covens Maria Cusimano Development/Faculty Awards Committee Brian Cox Karthika Devarajan Development (CPD/ Lisa Allen, Chair Maria Cusimano Nicole Gibbings FD) Committee Jon Barrett Rohan D’Souza Ronnie Hakim Theodore Brown Sarah Ferguson Dini Hui Filomena Meffe,Co-Chair Allan Covens Sari Kives Yolanda Kirkham Rory Windrim, Co-Chair Dan Farine Noor Ladhani Brian Liu Janet Bodley Sarah Ferguson Clifford Librach Roberta MacKenzie Adrian Brown Filomena Meffe Stephen Lye Haidar Mahmoud Nicolette Caccia Nanette Okun Siddhi Mathur Filomena Meffe Richard Pittini Richard Pittini Stephen Matthews Eva Mocarski Suzanne Wong Mathew Sermer Colleen McDermott Lauren Philp Department Rachel Spitzer Kellie Murphy Richard Pittini Appointments Rory Windrium John Snelgrove Dima Saab Committee (DAC) Arthur Zaltz Frances Wong Kiran Sahi Heather Shapiro Arthur Zaltz, Chair Quality Residency Program Michal Sheinis Lisa Allen Improvement and Committee Mara Sobel Adrian Brown Michele Farrugia, Chair Dana Soroka Theodore Brown Patient Saftey Anjali Aggarwal Scott Tigert Lilian Gien (QIPS) Committee Gareth Seaward, Chair Clarissa Bambao Danielle Vicus Kellie Murphy Nimrah Abbassi Janet Bodley Nathan Roth Hani Akoury Ali Corbey Mathew Sermer Lisa Allen Lilian Gien Jonathon Solnik Jon Barrett Shira Gold Fellowship Directors Adrian Brown Shapiro Heather Committee Stacy Costa Dini Hui Jennifer Cram Sari Kives Heather Shapiro, Chair Remi Ejiwunmi Marian Leung Dini Hui Elaine Herer Karen Levy Sari Kives Colleen McDermott Elizabeth Miazga

ANNUAL REPORT 2016/17 13 14 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Hospital Statistics

ANNUAL REPORT 2016/17 15 HOSPITAL STATISTICS

July 1st, 2016 to June 30th, 2017

MSH/ SMH UHN SHSC TEGH SK NYGH SJHC THP WCH Total Deliveries 2,738 6,494 4,249 2,891 NA 5,524 3,277 8,531 NA Caesarean- 29.4% 37% 38% 28.8% NA 29% 28.6% 25.8% NA Section Rate Total 1,344 2,619 3,092 1,755 136 4,180 1,257 8,271 1,630 Gynaecology Procedures (major and minor) Clinic Visits 54,855 160,205 16,871 10,436 2,351 29,0313 9,5303 4,445 8,450 (excluding private office visits) Number of 221 64 26 33 NA 52 30 874 NA Obstetrics Beds Number of 9 10 1 592 0 392 675 10 0 Gynaecology Beds

SMH St. Michael’s Hospital ¹ Does not include an additional 10 Labour, Delivery, MSH/UHN Mount Sinai Hospital/ Recovery, and Postpartum (LDRP) beds University Health Network 2 SHSC Sunnybrook Health Sciences Centre Shared with other surgical specialties TEGH Toronto East General Hospital/ 3 Includes breastfeeding clinic, colposcopy clinic, Michael Garron Hospital (newly named as of Dec 2, 2015) C-section prep clinic, non-stress test clinic, non- SK SickKids stress test assesssment clinic, private hospital tour, NYGH North York General Hospital RhoGAM injection clinic, Family Birth Centre SJHC St. Joseph’s Health Centre assessment clinic, FBC Foley Induction clinic, FBC THP Trillium Health Partners obstetrical consults clinic, FBC prenatal clinic, FBC (Credit Valley Hospital, Mississauga social work clinic Hospital and Queensway Health Centre) WCH Women’s College Hospital 4 Includes 27 birthing suites NA Not Available/Applicable 5 No gyne-designated beds; gyne surgeries go into surgery-designated beds

16 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Division Reports

ANNUAL REPORT 2016/17 17 CORE OBSTETRICS & GYNAECOLOGY

ARTHUR ZALTZ, Division Head

The Division of Core Obstetrics and Gynaecology is the largest division within the Department of Obstetrics and Gynaecology at the University of Toronto. Formally known as the “Generalists,” this group of physicians forms the infrastructure of the Department.

We are committed to providing excellent comprehensive care to our patients through a holistic lens, using an evidence-based approach. Our mandate is to impart the foundational knowledge, judgment, attitudes, and clinical skills necessary for our graduates to enter practice or pursue further sub-specialty training.

The Core Division includes members from the 3 major teaching sites: SHSC, SMH, MSH, and Trillium Health Partners, physicians from our long-standing community teaching sites (TEGH, SJHC, NYGH), and a growing number from other community centres across the GTA. With the granting of academic appointments to core specialists at the William Osler, site as well as the Scarborough Hospital, our divisional size has further grown.

Core specialists have had a major impact in the area of medical education. Dr. Michele Farrugia is the Program Director for Postgraduate Medical Education and Dr. Rajiv Shah is our Undergraduate

18 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY CORE OBSTETRICS & GYNAECOLOGY

Director. Dr. Janet Bodley serves as the Faculty Goals of the Core Obstetrics and and Resident Wellness Director and Dr. Richard Gynaecology Division Pittini is the Director of Evaluations, Undergraduate • To ensure that we provide comprehensive Medical Education, University of Toronto, and training for both community practice and Director and the Vice Chair of the Examination within academic centres for excellence within Board at the RCPSC. Many other members serve on core OBGYN the Examination Board of the RCPSC as well. • To encourage and support academic research within the Division Core specialists have also become leaders in the • To engage our partners across the GTA and area of Quality Improvement and Patient Safety. Ontario, by defining issues related to safety Dr. Amanda Cipolla is leading a local QI project that and outcome. This is currently being addressed will be taken up by the SOON network in looking through the GTA-OBS (SOON) Network, at caesarean section for failure to progress. which will draw upon over 70,000 births to define best practices Dr. Rachel Spitzer serves as the Vice Chair of Global • To allow trainees to pursue academic excellence Women’s Health Program and Dr. Mark Yudin is the from within the Core Division, by promoting Head of the Clinical Research Committee. and supporting postgraduate training in teaching, patient safety, public health, Global Women’s Within the Division, there is excellence in MIGS Health etc. (minimally invasive gynaecologic surgery), resulting • To promote the notion of the role of a core in a trend away from open hysterectomy and practitioner within the TAHSN system myomectomy to a minimally invasive approach. This • To engage our alumni to support our goals has led to improved patient satisfaction, safety, and through fundraising reduced length of stay. The last few years have seen a • To lobby for the health care rights of our patients surge in the grant funding and academic productivity with government within the MIGS group. Within this group there is expertise in managing complex surgery for the Awards and Grants management of deeply infiltrating endometriosis. 1. Dr. Ali Murji was the recipient of the Junior SMH offers robotic surgery for women with Stage 1 Faculty Award, University of Toronto. endometrial cancer and a high BMI. 2. Dr. Mara Sobel was the recipient of the 2017 CREOG Faculty Award For Excellence in There are city-wide MIGS rounds as well as Resident Education. collaboration amongst sites in research. 4 of our 3. Dr. Sari Kives was awarded the CREOG teaching hospitals train fellows in MIGS. Our MIGS National Faculty Award. surgeons are internationally recognized at the AAGL 4. Dr. Donna Steele was the recipient of the and SLS meetings, where they have served as faculty. Neelam Sierra Resident Advocacy Award. 5. Dr. Jamie Kroft is the Chair of the All residents train in core, before ultimately Laparoscopic Suturing Program at the deciding on whether or not to pursue one of the 2017 AAGL Annual Meeting. other subspecialties. Virtually all Obstetrics and 6. Dr. Jamie Kroft was the recipient of both an Gynaecology in the province, outside of academic Educational Research Grant looking at night float centres, is managed by core specialists. Within the and an AFP Innovation Grant for a TLH tool. University, it is the core division that takes on the 7. Drs. Lindsay Shirreff , Ali Murji and Adrian responsibility for most of the teaching at all levels, Brown received an AHSC Innovation Grant to from pre-clerkship to clerkship, postgraduate and develop a surgical scorecard. continuing medical education.

ANNUAL REPORT 2016/17 19 GYNAECOLOGIC ONCOLOGY

ALLAN COVENS, Division Head

In the 2016-2017 academic year, the University of Toronto, Division of Gynaecologic Oncology added a satellite site – Royal Victoria Hospital (RVH) in Barrie, including 3 faculty. In addition, faculty were added to Trillium Health Partners.

Tertiary/quaternary clinical services and teaching to followed by 2 clinical years. The program continues medical students, residents, and fellows continue to to attract a very large number of excellent Canadian be delivered at UHN, Sunnybrook, and Trillium, and international applicants. Furthermore, the while full-service, multi-disciplinary care is provided fellowship has graduated a number of individuals at all 4 sites. Academic/research activity is robust and who have gone on to become leaders in the diverse at each of the sites. specialty elsewhere. Drs. Harry Brar and Liat Hogen completed their training in June 2017. Dr. Brar The addition of RVH includes 3 Gynecologic was recruited to UBC, and Dr. Hogen is presently Oncologists each with University of Toronto working as a locum at UHN. New fellows coming appointments – Drs. L. Jutzi, A. Ball, and L. White. into the program are Julie Nguyen (from University With their clinical activity including not only the of Toronto), and Mitchell Clarke from the University Barrie area, but north to Sudbury, the University of of Connecticut. Toronto Gynaecologic Oncology reach is extensive. At the present time, electives for medical students, UHN has 4 faculty: residents, and fellows are available with their service. With our faculty of 17 Gynaecologic Oncologists, 1. Dr. Bernardini continues as the head of the we are one of the largest Gynaecologic Oncology division at UHN. He is the Co-Chair of the divisions in the world. Endometrial Cancer Working Group at the Canadian Clinical trials group (CCTG) and Our Gynaecologic Oncology fellowship program represents CCTG at the Uterine Task Force under Dr. Laframboise’s leadership continues to of the National Clinical Trials Network of the be the largest and only 3-year formal program NCI. He is also on the GOGO executive and is in Canada. The fellowship includes one-year of the secretary treasurer of the OOA, in addition research or formal education (master’s in public to a number of provincial committees including health, epidemiology, health services, or education), the Gyn Onc HHR for CCO. He holds a Senior

20 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY GYNAECOLOGIC ONCOLOGY

Merit Award from our Department. He leads the for recurrent clear cell carcinoma of the ovary. Prevent Ovarian Cancer Program at UHN. She is the Chair of the RPSC Sub-specialty Committee, and involved in the CBME design 2. Dr. Ferguson was awarded the J. Douglas for OBGYN residency. She continues to be Crashely Chair in Gynaecologic Cancer the lead for the university division’s resident Research at the University Health Network and education, and the Gynecologic Cancer site was also appointed to head of gynaecology at group at Sunnybrook. Cancer Care Ontario. She also received a Senior Merit Award from the Department, and was 3. Dr. Kupets continues in her role as the Scientific successful in a CCSRI innovation grant for her Lead for Ontario Cervical Screening, and is the project, Universal Screening for Lynch Syndrome Division’s lead on continuing medical education. in Women with Endometrial and Non-Serous Ovarian Cancer. She continues as the lead for the 4. Dr. Vicus was appointed to the Rare Tumour University Division’s research. Committee of NRG Oncology, and is leading the implementation of a large multi-national/ 3. Dr. May performed the youngest recorded cooperative group trial in mucosal melanoma. laparoscopic trachelectomy for cervical sarcoma She is also the lead on a large multi-institutional in a 2-year-old infant, and is also expanding her AIN study, receiving a McArthur Award research in low-grade serous ovarian cancers. She from the Division for her project, Screening is the coordinator of the fellowship curriculum, for Anal Cancer in Women with High-grade and in her final year of a junior merit award. Vulvar Dysplasia or Vulvar Cancer. She revamped our division’s undergraduate experience 4. Dr. Bouchard was awarded a position in the with very positive results, and is our lead for Patient Safety and Quality Improvement course undergraduate education. though C-Quips and is implementing NSQIP for gynaecology at UHN. She is also initiating 5. Dr. Osborne continues to be very active in GTN, a central program for gestational trophoblastic working to establish a centralized dedicated GTN disease at UHN/Sinai and is part of the clinic, and is the lead and senior representative for University of Toronto team hosting the ISSTD hosting the ISSTD in Toronto in 2019. meeting in Toronto in 2019. THP has 3 faculty: Sunnybrook has 5 faculty: 1. Dr. Sinasac (recruited in the fall 2016), is taking 1. Dr. Covens continues as the head of the division over the lead in global health that has been vacant at Sunnybrook. He serves on the GOGO since Dr. Rosen left. executive and board of OOA, and sits on the Gynaecologic Oncology HHR committee. 2. Dr. Murphy continues her role as Lead for He continues as co-chair of the Rare Tumour Cervical Cancer Screening and Colposcopy Committee for NRG Oncology, and is Co-PI in the Province of Ontario, and head of the of a large multi-cooperative group international woman’s program at THP. trial in Germ Cell Tumours. 3. Dr. Feigenberg was awarded a McArthur 2. Dr. Gien received a merit award from the Award from the Division for his project, Department, and continues to be active in Immune Assessment as a Predictor of Cytoreductive NRG oncology, including leading an NCI Surgical Outcome in Advanced Stage Epithelial multi-institutional study in immunotherapy Ovarian Cancer.

ANNUAL REPORT 2016/17 21 MATERNAL-FETAL MEDICINE

New focused areas of clinical excellence include a fetal neurology clinic at Mount Sinai Hospital under Dr. Tim Van Meighem, and a clinic for pregnant women with disabilities under Dr. Anne Berndl. At St. Michael’s Hospital, Dr. Tatiana Freire-Lizama continues to lead in simulation-based education.The fetal therapy team at Mount Sinai Hospital, lead by Dr. Greg Ryan, developed the first Canadian program for in-utero repair of fetal open neural tube defects, and performed the first case in early summer of 2017.

NANETTE OKUN, Division Head The Southern Ontario Obstetrical Network under Dr. Jon Barrett, continues to Our Division continues to be anchored strongly in 3 expand, now including London University-affiliated hospitals including Sunnybrook, Health Sciences Centre, and Mount Sinai Hospital, and St. Michael’s Hospital. has garnered the attention of With 3 MFMs in community sites, we are a division the MOHLTC, the Provincial of 29 members, providing consultative and ongoing Council for Maternal Child Health (co-chaired by Dr. care to close to 70,000 pregnancies per year in the Gareth Seaward), and the Greater Toronto Area. Better Outcomes Registry and Network (BORN Ontario) to allow greater alignment between Highlights the quality improvement initiatives of SOON and On the clinical front, we continue to provide those of the province. significant support and outreach throughout the GTA. With one full-time joint appointment between Our fellowship program continues to thrive under Sunnybrook and North York General Hospital (Elad the leadership of Drs. Maxwell and Czikk, with Mei-Dan), we are continuing to provide outreach ever stronger rotations at each of our TAHSN sites, services west in Missisauga, and east in Scarborough. and planned addition of a combined MFM/Genetics We are poised to hire 2 full-time fully affiliated fellowship as well as an MFM community rotation. members at Trillium Health Partners, and are actively exploring at least one more in Scarborough, Future Initiatives and another in Newmarket, with ongoing outreach We look forward to continuing to build a strong, clinics at the Michael Garron Hospital. functional network of academically satisfied and accountable division members into the GTA Grants and publications are listed elsewhere, and our community sites, partnered with and mentored by Division is among the most productive in this area, their TAHSN site colleagues to maximize both presenting leading research in international meetings, quality of care and research potential. We look and remaining one of the most well-known centres forward to further expanding the University of for innovation in MFM care and research (e.g., fetal Toronto MFM program internationally to Moi therapy, cardiac complications of pregnancy, prenatal University in Kenya with an MFM fellowship ultrasound diagnosis). based onsite, also strongly partnered and supported by our Division.

22 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY REPRODUCTIVE ENDOCRINOLOGY & INFERTILITY

THEODORE J. BROWN, Division Head

The REI Division comprises 22 sub-specialty- trained clinician educators, clinician investigators and scientists, 2 embryologist/andrologists, and 3 translational/basic scientists whose academic activities focus on various aspects of female reproductive endocrinology, fertility, and stem cell biology.

As one of the largest REI Divisions in North America, our members practice at one fully affiliated hospital or at 4 independent private fertility clinics. Collectively, these facilities offer a full range of diagnostic services; 4 have on-site, state-of-the-art embryology and andrology laboratories. Several of these clinics operate satellite clinics to better serve their patient population. An additional clinical highlight in the Division is the Mature Women’s Health & Menopause clinic located at Mount Sinai Hospital. This clinic includes a unique multidisciplinary premature ovarian failure (POF) clinic, co-directed by Dr. Wendy Wolfman and Dr. C. Kelley (Medical Endocrinology). The Division offers several fellowship training opportunities: an RCPSC-accredited GREI fellowship training at the Mount Sinai Fertility clinic and non-accredited GREI Fellowship Programs offered at the Create and Trio private fertility centres. A 2-year clinical fellowship in Mature Women’s Health is also offered by Dr. Wolfman.

ANNUAL REPORT 2016/17 23 Reproductive Endocrinology & Infertility

Highlights Future Initiatives Mount Sinai Fertility (MSF) opened a satellite The Division is preparing to launch an initative clinic in North York in the Fall of 2016. This clinic, to bring together REI specialists and researchers headed by Dr. Crystal Chan, offers consultations, across the Greater Toronto Area as a group to foster diagnosis, fertility treatment planning, and cycle greater collaboration to address key educational monitoring to MSF patients. Also in North York, needs and research questions facing the specialty, Dr. Marjorie Dixon officially opened Anova Fertility as well as to provide a platform for patient and and Reproductive Health, a full-service private IVF professional advocacy. We hope to hold an inaugural clinic. She is joined by Dr. Yaakov Bentov, who is session in early spring. The Division continues to also serving as the Director of Research within the make progress in establishing an academic training Centre. We congratulate Dr. Rebecca Arthur on program for clinical embryology and andrology, an her completion of her Master’s Degree in Quality effort headed by Drs. Heather Shapiro, Ted Brown, Improvement and Patient Safety (QuIPS), awarded and Yaakov Bentov. by the University of Toronto. Dr. Arthur is leading QuIPS initiatives at Mount Sinai Fertility. Members of the Division, led by Dr. Ellen Greenblatt, held a continuing education event in September on Clinical Evaluation and Treatment of Infertility. This well- attended and well-received event, delivered largely by division members and MSF Fellows, provided primary care practitioners with current topics to inform their management and guidance of patients facing fertility issues or concerns. Dr. Cliff Librach was elected to the Board of Directors of the Canadian Fertility and Andrology Society in 2016.

Honours Dr. Greenblatt was promoted to full Professor on the basis of her clinical professional activities in oncofertility preservation, advancing elective single embryo transfer, and promoting equal access to infertility treatment through advocating for public IVF funding. Dr. Dixon was named as one of 7 of 2017’s ‘Women of Distinction’ by the YWCA of Toronto for her advocacy work supporting women and the LGBTQ community in reproductive health and fertility.

24 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY PAEDIATRIC & ADOLESCENT GYNAECOLOGY

LISA ALLEN, Division Head

The Division of Paediatric & Adolescent Gynaecology (PAG) under the Division Head, Lisa Allen, includes PAG providers at SickKids (Anjali Aggarwal, Nicolette Caccia, Sari Kives, Rachel Spitzer), North York General Hospital (Ali Nevin), Michael Garron Hospital (Melanie Ornstein, Brenda Wood), and a transition clinic at Women’s College Hospital (Yolanda Kirkham).

At Sickkids, care is provided to children and adolescents with common conditions and rare challenges, with over 2300 ambulatory visits annually, and national referrals to its surgical complex anomalies program. In 2 community PAG clinics, North York General Hospital and Michael Garron Hospital, children and adolescents can receive excellent PAG care closer to home. A true strength of our program is our integration of reproductive health care into inter-professional teams caring for children and adolescents with complex care issues. The program participates in a transitional program for young women. Young women at the age of 17 are transitioned to the Young Women’s Gynaecology Program for the reproductive health care of women aged 17 to 25 at Women’s College Hospital.

The Vision of the Division is to provide leadership in advancing the gynaecologic care and treatment of young women in Toronto, Ontario, Canada and

ANNUAL REPORT 2016/17 25 Paediatric & Adolescent Gynaecology

around the world. In addition to our strong clinical Committee whose work includes developing PAG as care program, the Division leads with its activities an entrustable professional activity. across the scholarly areas of research, education at all levels including a fellowship in PAG, and creative Closer to home, on January 14th, 2017, the Division professional activity. hosted its semi-annual Continuing Medical Education Day. The successful Paediatric and Highlights Adolescent Gynaecology Review Day attracted a Our Division had an impactful presence at the diverse audience of attendees with excellent reviews. North American Society of Pediatric and Adolescent Gynecology (NASPAG) Annual Clinical The 6th annual Carol Cowell Lectureship in and Research Meeting held in Chicago in April 2017. Paediatric Gynaecology was presented by Dr. In addition to our faculty presenting a plenary on Nathalie Fleming, Professor and Head of Pediatric Managing Ovarian Masses: Finding the Right Balance Gynaecology at the University of Ottawa. Her and a luncheon on the Ethics of Consent in expertise in Adolescent Pregnancy has been paediatric gynaecology, 25% of the oral abstracts recognized by the provincial Minister’s Medal were original research from our Division. The Honouring Excellence in Health Quality and Safety. research presented spanned a wide variety of topics: use of tranexamic acid in adolescent abnormal Future Initiatives uterine bleeding; algorithms to guide surgical The Division looks forward to developing further decision-making with ovarian pathology; and the links and collaborations amongst the providers of use of innovative technology to assess risk behaviours PAG across the city. in pregnant adolescents.

Over the year, several other international invited lectureships demonstrated the impact of our Division. Dr. Allen travelled to Mexico City as an Invited Professor, presenting 3 plenaries at the III International Course of Pediatric and Adolescent Gynecology, COMEGO-NASPAG Clinical and Research Regional Meeting in September 2016. In addition, Dr. Allen participated in a panel session on paediatric gynaecology at the American Academy of Pediatrics, Surgical Section Symposium October 2016 in San Francisco. The Division continues to provide leadership in the important national and international PAG organizations. Dr. Kives is the Vice President of the North American Society of Paediatric and Adolescent Gynaecology. Dr. Rachel Spitzer is the Co-Chair of CANPAGO, the PAG specialty committee of the SOGC.

Dr. Caccia maintains an active role in the development of competency-based education. She is a member of the Royal College of Physicians and Surgeons of Canada (RCPSC) Competence by Design development for Obstetrics & Gynaecology

26 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY UROGYNAECOLOGY

PATRICIA LEE, Division Head

Urogynaecology – also known as female pelvic medicine and reconstructive surgery (FPMRS) – is a sub-specialty area within Obstetrics & Gynaecology that encompasses the care of women with bladder problems and pelvic floor disorders. The Division of Urogynaecology at the University of Toronto is the largest of its kind in Canada.

Core Faculty Among the 3 core University of Toronto teaching hospitals there are 8 recognized fellowship trained core urogynaecology faculty: Drs. May Alarab, Danny Lovatsis, Colleen McDermott (SHS); Dr. Dana Soroka (SMH); Drs. Janet Bodley, Louise-Helene Gagnon, Rose Kung, and Patricia Lee (SHSC).

We have urogynaecology colleagues beyond our core teaching hospitals who participate regularly in the education of our fellows: Drs. Bill Easton, Phaedra Diamond (Scarborough Centenary), and Harold Drutz (Baycrest Health Sciences); and those who participate in the training of our residents (non-elective and elective): Dr. Danny Kreichman (NYGH); Dr. Melissa Tai (TEGH); Drs. Allan Kanee, Kim Rogers, Carol Wade (Trillium Health Partners); and Dr. Stacey Grossman (York Central).

Collaboration We have strong collaborations with colleagues who complement our academic and clinical foci: Drs. Sender Herschorn and Lesley Carr (Urology, SHSC), Dr. Nucelio Lemos (Neuropelveology and Pelvic Pain, SHS), Dr. Oksana Shynlova (Basic Science, Lunenfeld Research Institute), Drs. Sidney Radomski and Dean Elterman (Urology, UHN), Dr. Louis Liu (Gastroenterology, UHN), Dr. Wendy Wolfman (Menopause, SHS), Drs. Herb Wong, Grace Lui, Jamie Kroft, and Leslie Po (SHSC Minimally Invasive Gynaecologic Surgery (MIGS) surgeons), and Dr. Mary Melchior (MIGS, SJHC).

ANNUAL REPORT 2016/17 27 Urogynaecology

Education Research Initiatives The Program teaches medical students, residents A major goal of the Division is the development (14 per year) and fellows (3-4 per year). Residents of collaborative University of Toronto multi-site rotate to either SHS or SHSC for their mandatory research projects. We have initiated 2 significant urogynaecology training. We offer urogynaecology projects: Intraoperative visualization of ureteric fellowship training at both the SHS and SHSC sites orifices using vitamin D, Health Canada of 2-3 years duration. We have created the academic approved; and Quality of Life surveys on patients and educational curriculum for a 2-site (SHS/SHSC) waiting for surgery. clinical fellowship (the first joint clinical FPMRS fellowship training program in Toronto since 2001). National and international meetings: The International Urogynecology Association (IUGA) Fellowship Accreditation Initiatives annual meeting was hosted in Vancouver, National guidelines for the standards of education Canada in June 2017 and was well-represented by and training in FPMRS fellowship programs University of Toronto faculty who participated have also been developed and are aligned with in oral presentations (MA, PL, NL, DL, CM), the American regulatory body, the Accreditation invited session moderators (MA, DL), and Council of Graduate Medical Education. A national invited workshop faculty teachers for fellowship committee with urogynaecologists (MA, CM) and trainees from around the world (PL, CM). The urologists (Sender Herschorn) has been in place and inaugural Canadian Society of Pelvic Medicine is working toward RCPSC sub-specialty recognition meeting was also held in Vancouver and for FPMRS. chaired by Dr. Harold Drutz. The University of Toronto Urogynaecology Division has been 26: Publications (Abstracts & Papers) asked to host the 3rd Annual Eastern Society 5: Peer-Reviewed Grants of Pelvic Medicine meeting in October 2017 8: Invited Speakers and the organizing committee (PL, DL, CM) 19: CME/Workshops has been busy with plans to deliver not only a comprehensive academic program, but also to Awards and Honours serve as a forum to unite our multidisciplinary • Adrienne Li, PGY6 (P. Lee) “Best in 3 Abstracts” colleagues in female pelvic health from both the oral presentation at SOGC (June 2017). eastern and western provinces. • Polina Myrox (MD candidate 2020), University of Toronto’s CREMS Summer Student Research Award (P. Lee and R. Kung). • Tumushabe Mutungi (OBGYN PGY3) Department of Obstetrics & Gynaecology, University of Toronto, Chair’s Summer Student Award (D. Lovatsis). • Michelle Anderson (MD candidate 2020) Department of Obstetrics & Gynaecology, University of Toronto, Chair’s Summer Student Award (C. McDermott).

28 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Program Reports

ANNUAL REPORT 2016/17 29 UNDERGRADUATE MEDICAL EDUCATION

student evaluations of their experience have been extremely positive. We thank all those involved in creating the sub-rotation and especially would like to acknowledge Drs. Koo Chun and Kiran Sahi.

In the last academic year, we piloted a simulation project on the topics of postpartum hemorrhage and perineal laceration repair to 3rd year clinical clerks at the Fitzgerald Academy. Students thoroughly enjoyed this format of learning. We evaluated the students’ knowledge and skills acquisition through this modality and found RAJIV SHAH, Director improvements in both technical and non-technical skills, as well as knowledge through the The Undergraduate Medical Education Committee simulation. The results have is committed to ensuring excellence in the teaching been presented internationally. A and training of our medical students by offering a special thanks to Dr. Eliane Shore diverse experience in the clerkship. who helped to create and rollout the simulation.

Highlights Honours Over this past year, we have worked in collaboration Congratulations to our 2016–2017 student with members of the Faculty of Medicine in award winners in recognition of their academic designing an entirely new Preclerkship curriculum achievements in our specialty: of the 1st and 2nd-year medical students. The new Foundations curriculum has a flipped • Dr. Jacob Goldstein Scholarship: classroom model where students spend no more William Kyle Silverstein than 3 hours in lectures per week and spend their • Hendry Memorial Scholarship: Emily Wright time divided between small group workshops, • Dr. Frederick R. Papsin Award: shadowing experiences and self-learning. In the new Ryan Joseph Paul Giroux curriculum, OBGYN has 4 weeks which are divided • Dr. Sidney M. & Roselyn Tobin Compassionate with 2 weeks of gynaecology including a portion Scholarship: Victoria Marianchuk on sex and gender-based medicine and 2 weeks of obstetrics. We wish to thank all faculty who have Future Initiatives helped contribute to the new curriculumwhich will As of this coming year, students can seek out learning be launched as of January 2018. opportunities at any academy to round out their educational experience. With Danielle Vicus, we will William Osler Health System (WOHS), with both also be introducing an academy-wide gynaecologic the Brampton and Etobicoke hospitals, has become oncology rotation for our medical students, as a result our new teaching site in the last academic year. of a highly successful pilot at Sunnybrook. Students from MAM spend 3 weeks at either BCH or EGH doing a sub-rotation. WOHS faculty have been extremely welcoming to the students, and the

30 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY RESIDENCY TRAINING PROGRAM

Commentary on the Development of a Night Float Call Model for Obstetrics and Gynaecology Residency: The Process and Resident Perceptions. Authors include: Lynn Sterling, Carmen McCaffrey, Rebecca Rich, Michael Secter, Jessica Green, Lindsay Shirreff, and Donna Steele. This article reviews our process for developing an innovative NF call model, along with resident perceptions and experiences, with the idea of offering insight for residency programs that are considering/ instituting alternative call systems.

The Residency Program MICHELE FARRUGIA, Director received an outstanding final report on July 28th, 2016 from the PGME Internal Review In 2016–17, our 68 residents trained at 9 clinical Committee (IRC). The IRC sites affiliated with our Residency Program. The identified 6 strengths of our Residency Program Committee (comprising faculty program, no weaknesses, and site/rotation-coordinators, and resident representation concluded, “No further action for each PG year) oversees a quality educational required.” Strengths included a strong supportive infrastructure experience designed to produce excellent practitioners in the Residency Program in Obstetrics & Gynaecology, as well as future leaders Committee and subcommittees, and researchers. the Resident Wellness Program, the LAR for PGY1s, extensive resident engagement, and an 12 PGY1s joined our program in July 2016; 10 excellent transition-to-practice rotation. The report Canadian medical graduates and 2 international stated that our wellness program “should serve as medical graduates. We congratulate the 13 PGY5s a model for other divisions and departments... It is who successfully completed the Royal College exams highly valued by the trainees.” in May 2017 and wish them all the best in their future endeavours. The Academic Half-Day (AHD) Subcommittee, a forum for residents to provide input to the AHD Highlights curriculum and address AHD issues, organized The OBGYN program added a Skills Test the first summer AHDs in 2016. This was most component to our 2017 CaRMS selection process, successful, and was to be repeated for the summer intended to help identify candidates who are most of 2017. Residents consider membership in this likely to succeed in a surgical program. The test AHD sub-committee a highly desireable role, and assessed basic eye-hand coordination and ability to have commented that it has contributed to their function in 3 dimensions. This component was under understanding of the difficulties (and joys) involved Dr. Eliane Shore’s leadership. in creating and achieving change.

We are pleased to announce the Night Float Participation in the Clinical Investigator Program (NF) Committee’s summary of the University of (CIP) remains strong. Lauren Philp is working Toronto experience. Implementing an NF system with Marcus Bernardini and Gang Zheng on Use was published in the JOGC in November 2016: A of Porphyrin-Based Nano-Theranostics to Detect Lymph

ANNUAL REPORT 2016/17 31 Residency Training Program

Node Metastases and as a Tool For Image-Guided • American Association of Gynecologic Lymphadenectomy: Proof of Concept in Endometrial Laparoscopists (AAGL) Award: Cancer and progressing toward a MSc at the Institute Aparna Sarangapani of Medical Sciences at the University of Toronto. • North American Society for Pediatric and Adolescent Gynecology Outstanding PGY1 residents have been participating in the (NASPAG) Resident Award: Lacey Harding RCPSC-mandated Surgical Foundations program • Dr. Frederick R. Papsin Postgraduate Award: since 2015. We salute the 13 PGY2s who voluntarily Carmen McCaffrey sat and passed the Royal College Surgical Foundation exam, which will be mandatory in 2018. 2017 Resident Graduation Celebration – Faculty Awards • CREOG National Faculty Award for Excellence Resident research projects led to approximately 16 in Resident Education: Mara Sobel presentations and 14 publications. For the purpose • The Neelam Sierra Resident Advocacy Award: of achieving more effective communications, Donna Steele the Residency Program issued a “first-ever” communications policy to outline communications Resident Awards – External standards and expectations: “Communications – • PARO Trust Fund Resident Teaching Award Commitment – Consideration.” (2017): Mathew Leonardi • Antonio Cecutti Prize, St Michael’s Hospital Future Initiatives (2017): Mathew Leonardi The RCPSC mandated the first major major • Detweiler Travelling Fellowship Award curricular change in all residency programs across (December 2016): Mathew Leonardi Canada in over a century: Competency by Design • Dr. Andrée Gruslin Award: Best of Best in (CBD). Obstetrics & Gynaecology is in cohort 4 Resident Research Presentation, APOG (2016): of the CBD rollout, with a planned start date for Rebecca Rich the PGY1 group in July 2019. Some of our sub- • Duchesnay International Elective Fellowship for specialty rotations have been using workplace-based Obstetrics and Gynaecology Residents (2016): assessments on a trial basis. In addition, we plan to Shambe Mutungi pilot other smaller endeavours in 2018–19 prior to • Gord Swayze Resident Academic Research the RCPSC rollout. Faculty development will be Award, Michael Garron Hospital (May 2017): a critical part of the success of CBD, and plans are Rebecca Zur underway to ensure our faculty members are aware • Peters Boyd Resident Teaching Award for of the curriculum, assessments, and their roles. 2016–17; Sunnybrook Health Sciences Centre, Women’s College Hospital, and North York Honours General Hospital: Maria Cusimano • Bruce Galloway Award, Society of Gynecologic 2017 Resident Graduation Celebration – Oncology of Canada (2016): Julie Nguyen Residency Awards • Frank Fletcher Memorial Fund Award: • Department of Obstetrics & Gynaecology Social Lauren Philp Responsibility Award in Global Women’s Health and Vulnerable Populations: Rebecca Rich • Excellence in Clerkship Teaching for 2015-16: PGY3: Maria Cusimano; PGY4: Kristen Harris; PGY5: Lynn Sterling and Mathew Leonardi • Society for Maternal-Fetal Medicine Residency Program Award: Kirsten Niles

32 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY FELLOWSHIP TRAINING PROGRAMS

HEATHER SHAPIRO, Director

The Department’s fellowship training programs continue to growth in breadth and depth. In the 2016–2017 academic year, there were over 30 fellows registered in Minimally Invasive Gynaecology Surgery, Urogynaecology, Advanced Obstetrics and Reproductive Sciences, and Menopause.

In addition, there were 14 trainees in Royal College to formalize fellowship evaluation. The Fellowship sub-specialty residency programs and 6 international Directors’ quarterly meetings are a forum to discuss fellows in MFM and Gyn Onc as well. As in previous common challenges and disseminate the policies years, the fellows outnumbered the residents. The developed by the university-wide Fellowship number of Ministry of Health-funded positions Advisory Committee. has remained static. The growth has been in the non-certified programs. This year, we welcomed City-wide fellowship rounds cover the non-core our newest fellowship, Women’s Global Health CanMEDS competencies and this year focused and Equity, under the direction of Rachel Spitzer, on Leader and Scholar. We provide 2–4 city-wide which is based at Women’s College Hospital. We seminars for fellows per year. Recent topics have have also actively been increasing opportunities been quality improvement and patient safety, for internationally trained physicians in fellowship leadership training and advocacy, and career programs. A complete list of programs can be found counselling. The latter has taken the form of on the department’s website (www.obgyn.utoronto. meeting with the Chair or information sessions ca/about-program-2). with community hospitals that are recruiting. Our Department-hosted graduation event, with Our fellowship programs contribute to the the inclusion of fellows with residents, has helped Department’s mission of research, clinical care and develop a strong sense of connection between the education. This was most evident at Research Day fellows and the University. where over two-thirds of the presentations and posters were co-authored by fellows. Looking forward to the next academic year, we hope to introduce CBD to both the Royal College Our programs have taken the lead on best practices programs and the fellowship programs. for online registration and are working with PGME

ANNUAL REPORT 2016/17 33 CONTINUING MEDICAL EDUCATION

Rounds Within our Department here in Toronto, weekly Grand Rounds continue to be presented in all of the academic sites. The MOREOB Interprofessional CPD Program was once again active at nearly all centres in the GTA. Led by Dr. Rachel Spitzer and Dr. Nanette Okun, we have continued our interactive Telehealth Obstetrics Rounds CPD program with our partner unit at Moi Teaching and Referral Hospital, Eldoret, Kenya. We presented more interhospital rounds to more sites than any RORY WINDRIM, Director, Continuing previous year, as listed below. These rounds were Professional Development & Knowledge Translation broadcast to all of our distributed sites and archived for interval review. Members of our Department, once again, represented our Department Honours in invited roles at many provincial, 1. Kim Liu: 2016 Chair’s Award for Excellence national and international CPD events. in Postgraduate Program Development and Innovation, Department of Obstetrics & Gynaecology, University of Toronto. 2. Jackie Thomas: Wightman Berris Academy Postgraduate Teaching Award 3. Rory Windrim: Wightman Berris Anderson Academy Award for Extraordinary Contribution to Education

Interhospital Rounds 2016/2017

Date Presenter/Topic Location Friday, September 9, 2016 Prof. Eileen Hutton St. Michael’s Hospital The Tale of Two Studies: Understanding Home Birth Outcomes Friday, October 14, 2016 Dr. Tim Rowe Sunnybrook Health Let’s Eat Grandma/Let’s Eat, Grandma: Sciences Centre The Importance of Editors Friday, November 18, 2016 Dr. Jenny Myers Mount Sinai Hospital New Advances in the Management of Chronic Hypertension in Pregnancy: A UK Perspective Friday, December 2, 2016 Dr. Tim Caulfield Hilton Toronto Cannell Lecture at APOG Conference: Quackademics, Popular Culture, and the Spread of Pseudoscience

34 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY CONTINUING MEDICAL EDUCATION

Date Presenter/Topic Location Friday, January 13, 2017 Dr. Nathalie Fleming St. Michael’s Hospital The Quest to Improve Teen Access to Multidisciplinary Prenatal Care in Canada Friday, February 24, 2017 Dr. Rabih Chaoui Mount Sinai Hospital 3D in Obstetrics: A Gimmick or a Powerful Clinical Tool Friday, March 10, 2017 Drs. Rachel Spitzer & Heather Millar St. Michael’s Hospital Creating Canada’s first Fellowship in Global Women’s Health and Equity Friday, March 17, 2017 Dr. Theresa Woodruff Mount Sinai Hospital The Emerging Story of Oncofertility: From Bench to Bedside to Babies Friday, April 7, 2017 Drs. Jon Barrett, Nanette Okun, Marie Czikk St. Michael’s Hospital and Howard Berger The Southern Ontario Obstetrics Network: Past, Present & Future Friday, April 28, 2017 Henderson Lecture University of Toronto Dr. Dorothy Shaw How Evidence Informs Advocacy for Women’s Health – A Lifelong Journey Friday, May 1, 2017 Dr. Tim Draycott St. Michael’s Hospital, Delivering Better Birthdays Li Ka Shing Knowledge Institute Auditorium Friday, May 12, 2017 Drs. Ray Osborne, Genevieve Bouchard- Sunnybrook Health Fortier and Naomi Martin Sciences Centre Gestational Trophoblastic Disease, The Toronto Experience Friday, June 9, 2017 Dr. Amy Fairchild North York General Go Ahead, Panic: from Yellow Fever in the Hospital Long 19th Century to Zika in a Hot Minute

CPD Courses Our Department presented a diverse range of courses, to more than 3000 attendees in 2016/17. These CPD events, all of which were University of Toronto and College accredited, addressed issues in Women’s Health in many areas ranging from Paediatric Gynaecology to Fetal Therapy.

ANNUAL REPORT 2016/17 35 Continuing Medical Education

CPD Rounds 2016/2017

Course Title Course Director(s) Clinical Evaluation and Treatment of Infertility Ellen Greenblatt 12th Annual Everyday Gynaecology: The Management Jackie Thomas of Common Gynaecologic Conditions International Fetal Therapy Simulation Training Course Greg Ryan, Rory Windrim, Tim Van Mieghem and Han Keunen The 5th International Fetal Growth Meeting John Kingdom Paediatric Adolescent Gynaecology Review Day Lisa Allen and Rachel Spitzer 13th Annual Obstetrical Malpractice: A Survival Guide for 2017 Dan Farine St. Michael’s Hospital Women’s Health Symposium Deborah Robertson 20th Annual Obstetric Ultrasound: Setting the Standard Greg Ryan and Rory Windrim for 2017 1st Annual MyGOALS: Multi-Disciplinary Gynecologic Taymaa May and Stephanie Lheureux Oncology Annual Lecture Series 13th Annual Mature Women’s Health Care Harold Drutz and Wendy Wolfman North York General Hospital Review Day Nicholas Pairaudeau 25th Annual Symposium New Developments in David Chitayat Prenatal Diagnosis Headaches and Hormones Michele Farrugia and Christine Lay

Future Initiatives Members of our Department have undertaken MSc, or PhD-level training with partner Institutions in Education, Research, Continuous Quality Improvement and Patient Safety, Competency-based Medical Education, and Knowledge Translation. We feel that this training will be the key to our future CPD growth. Our hope is to combine this expertise with the resources of the Southern Ontario Obstetrics and BORN Networks to develop a new vision for CPD in our Department. In this paradigm, we will augment our well-established CPD courses with externally funded research-based CPD interventions specifically developed in order to match perceived gaps in knowledge. We hope to evaluate the impact of the interventions by ongoing clinical practice audit.

36 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY GLOBAL HEALTH AND ADVOCACY

RACHEL SPITZER, Vice Chair, Global Health and Equity

Advocacy and Global Health, including our co-leadership in the AMPATH Reproductive Health collaboration in Eldoret, Kenya, remain a strong cornerstone of our Department and this year has been no exception, with many exciting developments. We continue to rely on a group of dedicated faculty and trainees who make our programs possible and highlight our leadership in this area among academic OBGYN departments nationally. Our Advocacy and Global Health track record and ongoing commitments are a source of great pride for us all.

Highlights In 2017, our fellowship program in Global Women’s Health and Equity proudly graduated Dr. Heather Millar as our first trained fellow, having spent a year as Team Leader for AMPATH-Reproductive Health in Eldoret, Kenya and having pursued a series of relevant rotations in Toronto and northern Ontario (through our partner, Northern Ontario School of Medicine, NOSM)) with underserved, immigrant and refugee populations. Our continuity clinic for the fellowship, based at Women’s College Hospital, continues to attract new patients and cater to a population of new Canadians and their reproductive health needs. We also recruited our fellowship candidate for the coming academic year amongst an impressive group of candidates from across North America. Our groundbreaking fellowship program

ANNUAL REPORT 2016/17 37 Global Health and Advocacy

was further the topic of our Annual Global Women’s continues under Kenyan leadership with North Health Inter-hospital Rounds and an invited American support and collaboration. Dr. Nanette keynote presentation at the Bethune Conference on Okun continued leadership in the area of MFM International Surgical Education. as, together with our Moi colleagues, there are plans to implement an MFM fellowship program When it comes to our Global Health contributions, in-country (based on the success and model of the our primary involvement remains in the Academic Oncology Fellowship) in the coming 18 months. Model Providing Access to Healthcare (AMPATH) Our videoconference rounds, made possible through in Kenya. AMPATH promotes equity and excellence CISEPO’s donation of the videoconference facility, in the care of women worldwide, and seeks to and featuring an MFM topic monthly and alternating build capacity in care, education, and research in presenters between our sites, continued through the sub-Saharan Africa. As part of our “Leading with academic year. Care” mandate, we have co-lead and implemented novel, as well as proven MNCH activities in 7 Honours innovative sites, covering a population 750,000. We In 2017, as an initiative of our Advocacy Committee, are extraordinarily grateful for the philanthropic we established departmental awards to annually support, primarily from the Purpleville Foundation, recognize a faculty and a graduating resident who and for other financial support received through have made a significant contribution to social other granting agencies, including USAID, Saving responsibility. The inaugural awards were presented Lives at Birth and Grand Challenges Canada, that to retiring former Department Chair, Dr. Alan has assisted us in rolling out these activities. Since Bocking, who championed global health in our 2013, this work has been scaled-up to partnerships Department and led us into partnership with Moi with 8 counties, 22 sub-counties, and a catchment University and Moi Teaching and Referral Hospital population of 3.5 million. In Kenya, Astrid as part of the AMPATH Consortium nearly 10 years Christoffersen-Deb leads the University of Toronto’s ago, and to Dr. Rebecca Rich, graduating PGY5, commitment to care, education, and research as for her research and advocacy in care for Indigenous Field Director for Reproductive Health. As in women in northern communities. previous years, in 2016/17, we enjoyed the rich exchange of trainees and faculty, including 2 medical Future Directions students travelling to North America, and medical We look forward to continuing leadership in student and resident exchanges to Kenya for clinical Advocacy and Global Health both locally and research experiences. within the University of Toronto Faculty of Medicine, developing shared opportunities Our gynaecologic oncology program, with in global health leadership, and nationally and continued support from Princess Margaret Hospital, internationally amongst the OBGYN and has continued to grow in the area of cervical cancer women’s health communities. screening, with over 50,000 women screened to date. Numerous grants are active in this area of the program including large NIH grants evaluating outcomes of LEEP and cryotherapy treatments in the setting and a project that is evaluating health determinants of acquiring an HPV infection. The fellowship program in Gynaecologic Oncology, initiated by Dr. Barry Rosen and his colleagues and team in Eldoret and North America, enrolled 2 new fellows in a 2-year program in Eldoret, which

38 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Committee Reports

ANNUAL REPORT 2016/17 39 PROMOTIONS & AWARDS COMMITTEE

LISA ALLEN, Chair

Academic promotion in the Faculty of Medicine confers recognition on the individual of the scholarly achievements of faculty members in their discipline. It recognizes the sustained excellence of faculty members in one or more of the areas of: research, education and creative professional activity.

The Promotion Committee’s main role is to recommend to the Chair of the Department and ultimately the Decanal Committee, individuals that should be promoted to the ranks of associate professor and full professor in each promotion cycle. In addition, the Committee is responsible to the faculty members of the Department to provide guidance and mentorship during their careers so they may best achieve senior promotion.

Collaboratively with the Faculty Development Committee, the Promotions Committee has developed a curriculum for senior promotions for the Department launched in 2017/2018. To supplement the longstanding Mentorship Program of the Promotion Committee, 6 rotating workshops will cover the topics of Creative Professional Activity, Choosing an Area of Excellence, Research, Teaching, Social Media, and Widespead Recognition as they relate to senior promotion.

40 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY PROMOTIONS & AWARDS COMMITTEE

A “Promotion Bootcamp” will occur at the onset of by the Royal Society of Physicians and Surgeons of each promotion cycle for potential candidates to assist Canada as being instrumental in the development them with negotiating the promotion process and of Gynaecologic Endocrinology and Infertility as a developing their dossiers. medical speciality.

The Committee consists of members at associate In 2014, she received an award from Fertile or full professor rank, who are chosen to reflect Future for her ongoing commitment to access to the diversity of the specialty, the diversity of oncofertility preservation for young people facing hospitals in the Department and to include expertise cancer. Dr. Greenblatt was invited by the Minister of on the Committee in promotion in each of the areas Health, MOHLTC, to chair the Advisory Panel on of excellence. Infertility that led to the Advisory Process for Fertility Services Key Recommendations Report. This report The Department is pleased to announce the guided the MOHLTC in the launch of the Ontario following senior promotion, effective July 1st, 2017. Fertility Program in 2015. Dr. Greenblatt has consulted nationally and internationally in her field Full Professor and with patient advocacy groups.

She is a past national director of the Canadian Fertility and Andrology Society, a Member of the Canadian Adolescent and Young Adults (AYA) Oncofertility group, and the Canadian representative to the Oncofertility Consortium Global Network. She was promoted on the basis of her Creative Professional Activities.

Ellen Greenblatt Dr. Greenblatt is the Medical Director, Mount Sinai Fertility, and Head Division of Reproductive Endocrinology and Infertility, Mount Sinai Hospital. After completing her medical degree at McGill University, she undertook additional training at McGill University and Western University, and completed an ABOG REI fellowship at the University of California, San Francisco.

Her scholarly activities have made important contributions to current practices in fertility preservation in young adults with cancer, as well as improving access to ART. Dr Greenblatt’s research is directed at improving outcomes and limiting complications as a result of assisted reproductive treatments, she has published more than 40 articles in peer-reviewed journals. In 2010, she was recognized

ANNUAL REPORT 2016/17 41 RESEARCH COMMITTEE

MARK YUDIN, Chair Scholar program, which supports residents wishing to enter the CIP and through the competitive The overall objective of the Research Chair’s Summer Student Award Program, which Committee is to support and facilitate provides partial support for the University CREMS Scholars and Summer Student programs. This year research within the Department, the Department provided support for Dr. Lauren with the goal of fostering research Philp’s CIP study on the use of nano-technology collaborations and providing support for the diagnosis of lymph node metastases in for the research training of residents endometrial cancer. Her supervisor is Dr. Marcus Bernardini. The Department also supported 19 and clinical research fellows. medical students through these programs. Dr. Kellie Murphy again offered a comprehensive This is accomplished by providing forums for 3-day intensive tutorial course on research for research education and the communication of departmental fellows and residents. We are grateful ongoing research. The committee consists of to multiple members of our faculty and to our approximately 18–20 faculty members with broad colleagues who contributed to the success of this representation from all Divisions and hospital sites, course. Dr. Mark Yudin hosts a resident research and meets approximately once per month. In addition forum on 3 academic half days throughout the year. to faculty members, 2 resident PGY1-5 (one of At these sessions, several residents present their which is participating in the Clinician Investigator research ideas to their peers and interested faculty Program) and one PGY6-8 fellow representative are to receive feedback and suggestions to overcome elected by their peers to sit on the Committee. perceived barriers. The sessions are held at the Li Ka Shing Knowledge Institute at St. Michaels Highlights Hospital and all faculty are welcome to attend. He The Research Committee with the help of the also sits on the Residency Program Committee as a administrative staff organizes the Department’s bridging member between the 2 committees. This Annual Research Day, held this year at the St. has improved coordination and communication Lawrence Centre for the Arts. The event celebrates between the committees regarding the Trainee and showcases the depth and diversity of research Research program and initiatives. within our Department. This year we introduced an electronic poster format that was well-received Future Initiatives and generally increased interactions at the poster This year, Dr. Murphy with the help of Michael presentations. A key event incorporated into Browne, launched a quarterly newsletter to Research Day is the D. Nelson Henderson Lecture, communicate research accomplishments to the first established in 1965. This year’s speaker was Dr. Department at large. We will continue to solicit Dorothy Shaw who spoke on how evidence informs contributions to this communication and to initiate advocacy for women’s health. The Committee also ways of expanding the visibility of publications from hosts an interactive research session every year on a our faculty members. The Committee is committed topic that bridges 2 or more clinical divisions. This to ensuring the Research Forums series continue, as year’s session, organized by Drs. Sarah Ferguson these can serve as an excellent platform to promote and Allan Covens, was on Surgical Advancements research collaborations. This year’s session will focus in Gynaecology and Gynaecological Oncology. A on Global and Indigenous Health research and will priority of our Department is to enhance research be organized by Dr. Rachel Spitzer. capacity by providing opportunities for our most promising trainees and young faculty. This is accomplished, in part, through the Women’s Health

42 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Chair’s CREMS Students & Summer Studentship Awards

This year, we had 8 students introduced the Chair’s Summer participate in the CREMS Studentship Award, a departmental (Comprehensive Research program that sponsors student Experience for Medical Students) participation in research projects with Summer Student program with our faculty. We were very impressed supervisors from our Department. by the work done this summer by all 10 students, and we hope that The CREMS program provides UofT these programs will continue to be students with an opportunity to do a successful at promoting research in our 12-week mentored research project Department going forward. with faculty at the University of Toronto, giving them an introduction Here are short profiles on each student to research. In addition, we also and the projects they were involved in.

ANNUAL REPORT 2016/17 43 CREMS STUDENTS

 Polina Myrox This summer, I had the incredible opportunity to participate in a CREMS project under the supervision of Dr. Lee and Dr. Kung. This project was located at the Sunnybrook Health Sciences Centre, in the Urogynaecology Division of the Obstetrics and Gynaecology Department. The goal of the study was to determine if there was a difference in the pain experienced by patients after gynaecological surgery when bupivacaine-soaked vaginal packing was used as opposed to estrogen cream-soaked vaginal packing. During this project, I had the opportunity to learn from several fantastic clinician scientists about the impact of research on clinical practice and the development of a research study. This experience has taught me invaluable lessons on the process of designing a research  Alexandra Davidson study, the hurdles that have to be overcome in Over the course of the summer I was fortunate order to begin a study, the challenges that are faced enough to collaborate on several projects in the in collecting information from patients, and the Department of Obstetrics & Gynaecology. I worked excitement of contributing new information to the closely with 2 amazing staff at St. Michael’s Hospital, medical community. Dr. Rajiv Shah and Dr. Eliane Shore. My research In addition, I was also given my first exposure to focused on simulation training as a teaching method obstetrics and gynaecology. During this experience, in undergraduate medical education. We ran pilot I had the opportunity to observe clinical encounters workshops for the 3rd year clerkship students rotating with patients in order to better understand the through St. Michael’s Hospital to assess 2 simulated focus of a gynaecologist. Most excitingly, I had the OBGYN scenarios, perineal laceration repair, and opportunity to post-partum hemorrhage. In addition to evaluating observe several the outcomes of the pilot workshops, I got to be minimally invasive personally involved in the delivery of the simulation surgeries, which is seminars, where I was able to directly learn about something I would the students’ experiences with simulation and their not have had the perspectives on current clerkship education. opportunity to do I am incredibly grateful to have had the opportunity otherwise. Overall, to work with Dr. Shah and Dr. Shore over the course my experience of the summer, and I am eager to continue to be working with Dr. involved with their projects throughout the coming Kung and Dr. Lee years. They both facilitated a relaxed and comfortable at Sunnybrook work environment that encouraged me to foster Health Sciences independence in my assignments and practice leadership Centre was with my colleagues. This project has helped me further fantastic and develop my research knowledge far beyond my previous has inspired wet lab experience. I am looking forward to following my passion for this work into the future and continuing to build on the obstetrics and new set of skills I gained from this summer. gynaecology.

44 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY CREMS STUDENTS

 Hanna Goldberg I was very fortunate to have been given the opportunity to work with Dr. Sari Kives and Dr. Lisa Allen through the CREMS Summer Student Program. Our project is investigating the prevalence of Avoidant/Restrictive Food Intake Disorder (ARFID) in the Pediatric Gynaecology Clinic and its impact on the menstrual cycle. Similar to patients with anorexia nervosa, individuals with ARFID demonstrate weight loss, malnutrition, abnormal eating behaviours, and a high prevalence of anxiety. Therefore, there is reason to suspect that this population may also be at risk for menstrual dysfunction. It is our hope that our project will increase awareness of ARFID and potentially, its  Navneet Natt relationship with menstrual dysfunction. As a result, I am very fortunate to have had such an incredible physicians will have a lower index of suspicion of a CREMS experience this summer under the possible eating disorder when treating adolescents supervision of Dr. Rohan D’Souza. He was an with menstrual dysfunction. amazing supervisor and supportive mentor that made Spending my summer with the Paediatric all the difference in my research experience. Gynaecology Department at SickKids has been an My CREMS project was a retrospective cohort excellent experience. I have gained important skills study about insulin requirements in diabetic in clinical research that I will continue to develop pregnancies. From the outset, Dr. D’Souza was throughout medical school and in the future as a very open to gauging my research interests and physician. Throughout the summer, I also spent determining which research skills I wanted to time in clinic and in the OR with Dr. Kives, which develop. Having only previously worked on was not only useful for my research project, but also systematic reviews, we decided together that it would allowed me to further explore the field of Obstetrics be valuable for me to learn about observational and Gynaecology. I am very grateful to Dr. Kives studies and get involved in the steps of conducting and Dr. Allen, the Department of Obstetrics and one. I appreciated the fact that he was so receptive to Gynaecology, and the CREMS Program for this tailoring this experience to my learning needs so that opportunity. I am excited to share our results when I could walk away with new research skills. the study is completed. Having never done pure clinical research before, I was a little nervous about diving into this project, but Dr. D’Souza was an invaluable source of support throughout. From the first day that I stepped into the diabetes clinic, Dr. D’Souza took time from his clinic hours to introduce me to the staff and orient me to the charts. All in all, I couldn’t have asked for a more productive or enjoyable CREMS experience. I hope all future CREMS students can work with a supervisor as incredible as Dr. D’Souza. He is the definition of an ideal clinician role model and research mentor!

ANNUAL REPORT 2016/17 45

 James Bao During my experience in the Comprehensive Research Experience for Medical Students (CREMS) Summer Program I completed a research project entitled: “A Delphi Approach for the Design of an Intra-Operative Blood Conservation Pathway for Open Myomectomy”. This was a collaboration between the departments of gynaecology (Drs. Robertson and Shore and Simpson), anaesthesia (Dr. Hare), and hematology (Dr. Sholberg). I have been invited to present at 2 national conferences – as an oral presentation at the Society of Obstetrician and Gynaecologists of Canada’s 73rd Annual Clinical and Scientific Conference (June 2018), and as a poster presentation at the Canadian Anesthesia Society Annual Clinical Meeting (June 2018). We are now finalizing the manuscript for submission for publication.

 Arianne Cohen My CREMS research project at the Mount Sinai Fertility Clinic with Dr. Crystal Chan and Dr. Ellen Greenblatt has been overall a great experience. The project itself consisted of a retrospective cohort review of patients who underwent an Endometrial Receptivity Assay (ERA) over the past 3 years. What I liked most about my summer research was the fact that I was able to see the project to fruition from the very beginning stages. I was involved with writing the Research Ethics Board application and certain aspects of the study design before the project formally began, which provided me with an excellent overview of the project and a sense of ownership. Though I had great advice and direction from my 2 supervisors, I felt like I was given a generous amount of independence with the project. The mentorship I received was invaluable to my learning and from it, I feel more confident in my research and critical appraisal skills.

46 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY CREMS Students

 Courtney Firestone For my CREMS project this summer, I had the opportunity to work with Drs. Mara Sobel and Melissa Walker to examine the outcomes from the Familial Ovarian Cancer Clinic at Women’s College Hospital. We assessed the demographics of the clinic’s patient population and were particularly interested in the number of precursor lesions identified in women undergoing prophylactic salpingectomies and oophorectomies. The results from this study will inform future decisions on how we counsel patients regarding ovarian cancer prophylaxis, and provide support for the use of the SEE-Fim pathology protocol when processing these surgical samples. This summer studentship was my first experience with clinical research and as I conducted my retrospective chart review, I could appreciate the difficult decisions that patients struggle with to minimize their risk of devastating diseases like ovarian cancer, while balancing competing concerns such as family planning and the risks of early menopause. I am grateful to have had the chance to explore an aspect of women’s health that I am sure to carry forward into my career as a physician.

 Dong Vao Wang It has been an absolute privilege to work with Drs. Murphy and Shea over the past summer. While I had background in mental health and pharmacogenetic research, I did not have a strong foundation in obstetrics and gynaecology. Drs. Murphy and Shea tirelessly answered all of my questions and helped me to get oriented in the Department. Their guidance helped to ensure that my summer research was successful. My project aimed to examine whether genetic differences in maternal drug metabolism of antidepressants influence the neonatal adaptation in the first few days of their lives. We hope the information would enable clinicians to optimize mental health care for women during pregnancy.

ANNUAL REPORT 2016/17 47 SUMMER STUDENTS

 Danielle Meschino I am a 3rd-year medical student, who had the pleasure of working with Dr. Wendy Wolfman and Dr. Alison Shea in the Department of Gynaecology and Women’s Unit at Mount Sinai Hospital. With a focus on the pharmacologic management of the genitourinary syndrome of menopause, My research allowed me to develop a greater understanding of the importance of women’s health and quality of life, especially surrounding the menopausal transition. By working alongside the incredible staff in both units, I not only developed an appreciation for the value of expanding research and knowledge within the field, but also for the importance of patient- centred care. I could not have asked for a better introduction to the discipline of Obstetrics and Gynaecology and look forward to further exploring the specialty during my clerkship.

 Jacqueline Parrish I am very pleased to have helped conduct a cross- sectional study with the Urogynaecology Divison at Mount Sinai Hospital analyzing the proportion of patients with overactive bladder who also have bothersome anxiety symptoms. The study was titled, Is Overactive Bladder Independently Associated with Anxiety. I successfully recruited the entire planned cohort of 100 patients from the ambulatory clinics during the 3-month project. I was also involved in protocol development and ethics submission. I will be a co-author on the manuscript, which is in the final process of editing and submission to the International Urogynecology Journal.

48 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY SUMMER STUDENTS

 Sandra Fiset Over the past summer, I worked with the Women & Babies program at Sunnybrook Research Institute thanks to the funding provided by the Chair’s Award. My project was about the prediction of preterm birth of twins using machine learning and texture analysis of cervical ultrasound images. This involved working with a multi-disciplinary team consisting of sonographers, radiologists, maternal fetal medicine specialists, and imaging researchers. I learned as much as possible from all my team members which gave me a well-rounded perspective on the practice of medicine, and particularly obstetrics. I am keen to incorporate what I have learned  Angela Han to my future studies on my path to becoming a I am currently a 3rd-year medical student at the physician. Not only did I gain amazing experience University of Toronto, and I had previously held an over the summer, but my project also took home evolving interest in the field of oncology for future the second-place prize at the Sunnybrook Research career and research pursuits. I sought after a summer Institute poster day for Evaluative Clinical Sciences. I studentship with Dr. Ferguson because of her am very grateful to have been given this opportunity extensive research work in gynaecologic cancers. The and I would like to thank all those who contributed research project that I became involved in resonated to my experience at Sunnybrook. Thank you! with my interests in multiple ways. Our study, Access to Endometrial Cancer Surgery and Outcomes in Morbidly Obese Women, was aimed at exploring the experiences of these patients as they navigated the health care system through their cancer journey. The project introduced me to qualitative research, a field with which I was previously unfamiliar, and allowed me to more deeply reflect on the personal circumstances of cancer patients. Over the course of the summer, we interviewed women with low-grade endometrial cancer who were also morbidly obese, and captured their insights about both the positive experiences and challenges they endured through their cancer care. The next steps of the study involve analyzing the interview transcripts and summarizing the essence of the experiences of these women. I valued the opportunity to refine how I communicate with patients on sensitive topics during interviews, which I will carry on in my future practice as a clinician. I wish to express my gratitude again for allowing me to have this amazing opportunity and I hope my research this summer will contribute in a meaningful way to the field of obstetrics and gynaecology.

ANNUAL REPORT 2016/17 49

 Michelle Anderson My name is Michelle Anderson and I participated in the 2017 Chair’s Summer Studentship Award Program in the Obstetrics and Gynaecology Department. At the end of this summer, I will be starting my 2nd-year of medical school at the University of Toronto. I have participated in 2 primary projects this summer. The first project was a study on optimal ureteric visualization at the time of pelvic reconstructive surgery. This project hit an unexpected roadblock and required Health Canada approval for the use of Vitamin B. I therefore focused on completing the paperwork required for Health Canada approval, which is still pending. Through this process, I gained a greater appreciation for the steps involved in acquiring research ethics approval, and what should be included in the review of relevant literature. The 2nd project was research on educating patients for the management of overactive bladder using written versus verbal instructions. For this study, I was involved in patient recruitment, and data collection and entry. I was able to interact with patients and learn more about the collection of information for a clinical research project. I  Claire Stanley anticipate that once data entry is complete, which This summer I had the honour of working with Dr. should be this fall, I will assist with manuscript Amanda Selk on a research project which aims to preparation and present these results at the better understand the attitudes and beliefs of women Department of Obstetrics & Gynaecology’s Annual in North America surrounding placentophagy. Research Day in May 2018. This study was a prospective, mixed methods design using an online survey and focus groups. By better understanding women’s attitudes and beliefs surrounding this increasingly popular practice we hope to direct future research about safety and efficacy. This was my first exposure to clinical research and a wonderful opportunity to learn valuable research skills. Additionally, as I am interested in a career in obstetrics and gynaecology, I was able to gain clinical exposure with Dr. Selk, which helped to further my knowledge and interest of this field. This exposure also helped me gain an appreciation of the value of such research to patient care. I would like to thank Dr. Selk for providing me with ongoing support and mentorship along the way.

50 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Summer Students

problem you’re trying to solve, that tedium gives way to drive. I am motivated to answer the research question of my main project because I want to change practice and improve patient outcomes. This research project gave me the opportunity to do something I truly care about, and for that, I am grateful.

 Anastasia Levinta Invasive placentation is a relatively common complication in pregnancy and is associated with  Avneet Bening significant morbidity. It has been shown that My name is Avneet Bening. I am about to enter antenatal diagnosis, as well as appropriate team- my 3rd-year of medical school. I started my post- based management of delivery, reduces the risks for secondary journey at McMaster University earning morbidity. However, no screening and management my BHSc Honours degree, followed by attending protocols have been established yet. University of Toronto for my BScN. I worked as a Our research focused on the development of labour and delivery/postpartum RN at Sunnybrook knowledge translation (KT) tools for diagnostic Health Sciences Centre and absolutely loved my job. protocol optimization of patients with this condition. There was, however, a pesky itch I couldn’t scratch. KT refers to a systematic approach aimed to A voice in my head whispering, “Look at what the enhance the uptake of existing research findings and medical students, residents and staff are doing – boy, incorporation of these into practice, at both clinical doesn’t that look like fun?” Eventually this whisper and policy levels. became a roar I could no longer deny and I decided Our final selection of tools was based on the to apply to medical school. literature review comparing the effectiveness of My previous work in the obstetrical field has various strategies, and included an infographic poster, definitely shaped my future aspirations. Nothing I an educational video, and a mobile app. Future was exposed to seemed to grab hold of me quite like work will focus on assessing the effectiveness of the learning about placenta previa or pre-eclampsia. This dissemination strategies above. research opportunity is gynaecology focused, allowing me to explore this aspect of the specialty further. Additionally, my goal for this summer was to get my feet wet in research, considering my past experience and exposure to gynaecology had been minimal. This opportunity provided me with just that. I have been privileged to have an excellent PI who never fails to answer my questions and is entirely supportive in my learning. Dr. Kroft has gone above and beyond by linking me with other ongoing projects to round out my experience and provide me with exposure to research studies with differing designs and methodologies. One thing I have learned is that the process of conducting research is not necessarily an exciting or dazzling process – it can be slow and tedious. However, if you are inspired and passionate about the

ANNUAL REPORT 2016/17 51 Summer Students

 Kainat Amir I had an incredible experience working at Sunnybrook Hospital, as well as North York General Hospital, over the summer of 2017. Working on a research project under the guidance of Dr. Elad Mei- Dan, along with the support from other supervisors and colleagues, made the work environment very comfortable and enjoyable. I found the research position to be flexible and engaging; while there was discipline and direction that allowed me to easily navigate how best to conduct my research, it still challenged me to improve on my own methods of data collection and learn statistical analysis. It was also pleasing to see the project come together, be a part of it, and to share it with others who had such innovative works of their own. I will always look back on this experience with gratitude, as it was an opportunity that allowed me to learn, to acquire valuable research skills, and to look forward to such experiences in the future.

 Tiahna Warkentin This summer I conducted research under the supervision of Dr. Berndl in the Women and Babies department at Sunnybrook Hospital. Specifically, my role included the development of a survey aimed to explore pregnancy experiences and outcomes for Little People, distributed to Little People Canada. The goal is to use the results to understand the pregnancy outcomes, including risk of preterm birth and caesarian section, for Little People, with the aim of improving evidence based antenatal care for this population. In addition, I conducted a descriptive study aimed to examine breastfeeding strategies used by women with physical disabilities. Interim results were accepted as an oral presentation at the Pacific Rim International Conference for Disability and Diversity in Honolulu. Interviews are currently ongoing. Following data analysis, the results will be used to develop breastfeeding guidelines for this population.

52 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Events, Significant Honours & Awards

ANNUAL REPORT 2016/17 53 34TH ANNUAL RESEARCH DAY

54 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY 34TH ANNUAL RESEARCH DAY

The Department hosted another successful Research Day, on Friday, April 28, 2017 – our 34th Annual Research Day. This year, there were several highlights. Firstly, we moved away from conventional printed posters to electronic posters which were displayed on large HDTV screens located throughout the venue. Secondly, with the introduction of e-posters, it allowed us an expanded range of venue options, because e-posters require a smaller footprint than conventional printed posters. This year’s venue was the St. Lawrence Centre for the Arts, located in the St. Lawrence Market neighbourhood. Thirdly, we were pleased to welcome Dr. Dorothy Shaw, as our Henderson Lecturer. Dr. Shaw is a professor at the Department of Obstetrics & Gynaecology at the University of British Columbia (UBC) and is Vice-President, Medical Affairs at BC Women’s Hospital. Dr. Shaw’s presentation was entitled, How Evidence Informs Advocacy for Women’s Health – A Lifelong Journey.

For the 34th Annual Research Day, we had 315 people registered and 117 abstracts submitted. The Research Committee would like to thank everyone who participated, our administrative staff and volunteers, who worked hard to put it all together, and as always for those faculty members who evaluated the presentations as chairs and judges. Special thanks to Theodore J. Brown as the Deputy Chair and faculty lead for Research Day, and to Kellie Murphy as Vice-Chair, Research, for their leadership in profiling the great and enriching research and talent that our department nurtures. The 2017 J.W. Knox Ritchie Award recipients who represent the best abstract/presentation in each of the trainee categories are listed herein.

ANNUAL REPORT 2016/17 55

Oral Presentations LEGEND (1) Department of Obstetrics O1 - Use of Audio Computer- O7 - Non-Anticoagulant Actions & Gynaecology, Assisted Self-Interviews (ACASI) of Low-Molecular-Weight University of Toronto to Gather Information on Risk Heparin in Preeclampsia Behaviours in a Referral Population Dora Baczyk (3), John (2) Other of Pregnant Adolescents Kingdom (1), Jovian Wat (3) (3) Lunenfeld-Tanenbaum Anjali Aggarwal (1), Carol King Research Institute (6), Carolyn Sheehan (6), Lisa O8 - Oxygen-dependent JMJD6 Allen (5), Rachel Spitzer (1) Regulation of Fibronectin Synthesis (4) St. Michael’s Hospital and Assembly in the Human Placenta O2 - A Single Course of Prenatal Isabella Caniggia (3), (5) Mount Sinai Hospital Glucocorticoid Treatment Modifies the Sruthi Alahari (3) (6) Hospital for Stress Response and Pituitary Gene Sick Children Expression Across Two Generations O9 - Dual Trigger vs. hCG for Final Alexandros Mouratidis (7), Alisa Oocyte Maturation: A Prospective (7) Department of Kostaki (7), Stephen Matthews Randomized Controlled, Double Physiology, University (7), Vasilis Moisiadis (7) Blinded Study – Preliminary Results of Toronto Jigal Haas (1), Rawad Bassil O3 - The Expression of Major ECM (1), Robert Casper (1) (8) Sunnybrook Health Proteins-Collagen and Elastin- Sciences Centre is Enhanced By Local Estrogen O10 - Feasibility and Safety of Same- (9) Trillium Health Partners Therapy in Postmenopausal day Discharge after Laparoscopic Women with Severe POP Radical Hysterectomy for Cervix Cancer (10) University Health May Alarab (1), Oksana Shynlova Allan Covens (1), Danielle Vicus (1), Network (1), Stephen Lye (3), Tanya Tyagi (1) Kate Pulman (1), Lauren Philp (1), Lilian Gien (1), Rachel Kupets (1) (11) Women’s College O4 - Kidneys in a Dish: Making Kidney Hospital Organoids from Embryonic Stem O11 - BRCA1 Modulates Inflammatory Cell-Derived Renal Progenitors and EGFR Signaling in Human (12) North York Andras Nagy (1), Ian Rogers Fallopian Tube Epithelium General Hospital (1), Jennifer Whiteley (1), Alexandra Kollara (1), Alicia Theresa Chow (3) Tone (10), Angela Lau (7), Barry Rosen (10), Carl Virtanen O5 - Increasing Pregnancy Health (10), Ellen Greenblatt (1), Julia Services Uptake through Integrated Hollingsworth (1), K. Joan Murphy Peer Support Groups in Kenya: (9), Lisa Allen (1), Terry Colgan (5), Theodore Brown (1), Tomer A Prospective Cohort Study Feigenberg (1), Valerie Dube (8) Astrid Christoffersen-Deb (1), Heather Millar (1), John Snelgrove (1), Rachel Spitzer (1) O12 - Suboptimal Placental Perfusion is a Potential Mechanism for IUGR and O6 - A Cost-Effectiveness Analysis of Worse Perinatal Outcomes of Non- Preimplantation Genetic Screening with Presenting Fetuses in Dichorionic twins In Vitro Fertilization in Ontario, Canada. Christopher Sherman (8), Eran Heather Shapiro (1), Nanette Okun Weiner (1), John Kingdom (1), (1), Rhonda Zwingerman (5), Jon Barrett (8), Kristine Giltvedt1 Wanrudee Isaranuwatchai (4) Giltvedt (1), Mia Kibel (8), Michael Kahn (1), Nir Melamed (8)

56 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY 34th Annual Research Day

Poster Presentations

O13 - Matched Histological Assessment Yields Clinical Refinement Education – Obstetrics I – Within Placental Transcriptional ePoster Session 1A ePoster Session 1B Subtypes of Preeclampsia Brian Cox (7), David Grynspan (2), 1A1 - Impact of Resident 1B1 - Impact of Cell Saver on Katherine Leavey (7), Samantha Overnight Duty Hour Changes Allogenic Transfusion Rates at Benton (2), Shannon Bainbridge (2) on Obstetrical Outcomes: A Caesarean Delivery in Women with Population-Based Cohort Study Abnormal Invasive Placentation O14 - Prospective Validation of Sentinel Brian Liu (1), Grace Liu (1), Ally Murji (5), Greg Ryan (1), John Lymph Node Biopsy with Indocyanine Jamie Kroft (8), Janet Bodley Kingdom (1), Jose Carvalho (5), Green Flourescence Imaging in (1), Michael Ordon (4) Lisa Allen (1), Rory Windrim (1) High-grade Endometrial Cancer Allan Covens (1), Aysha Zia (1), 1A2 - Modelling the Learning Curves 1B2 - The Effect of Maternal Blaise Clarke (10), Danielle Vicus of Incoming Surgical Trainees Antidepressants on Third Trimester (1), Emily Van de Laar (10), Gabrielle Ana-Maria Iancu (1), Donna Steele Uteroplacental Hemodynamics and Ene (10), Geneviève Bouchard- (1), Eliane Shore (4), Marisa Louridas the Neonatal Abstinence Syndrome Fortier (1), Lilian Gien (1), Lisa (2), Najma Ahmed (2), Natashia Alison Shea (1), Ariel Dalfen (5), Erlich (8), Mahmoud Khalifa (8), Seemann (2), Teodor Grantcharov (4) Katie McLean (1), Kellie Murphy (5) Marcus Bernardini (1), Maria Cusimano (1), Marjan Rouzbahman 1A3 - Implementation and Validation of 1B3 - Characteristics of Myometrial (10), Patricia Shaw (10), Rachel a Retroperitoneal Dissection Curriculum Kupets (1), Ravi Mohan (10), Sarah and Decidual Chemokines Abheha Satkunaratnam (4), Ferguson (1), Stephane Laframboise Responsible for the Activation Aisha Yousuf (1), Eliane Shore (1), Taymaa May (1), Ur Metser and Infiltration of Peripheral (4), Helena Frecker (1) (10), William Chapman (10) Leukocytes During Hyman Labour Oksana Shynlova (1), Stephen 1A4 - Implementation of a New Lye (3), Tali Farine (7) Gynaecology Curriculum in the University of Toronto Obstetrics and 1B4 - Uterine Arteriovenous Gynaecology Residency Program Malformation: A Case Series Aisha Yousuf (1), Eliane Shore (4), and Review of the Literature Katie Dainty (4), Sari Kives (4) Eva Mocarski (4), Siddhi Mathur (1), Sophie Bussiere-Cote (1) 1A5 - Understanding the Experiences of Obstetrics and 1B5 - Probiotic Lactobacillus Gynaecology Residents Who Take Rhamnosus GR-1 Supernatant Parental Leave During Training in Regulates LPS-induced Cytokine Canada: A Needs Assessment Production in Human Myometrial Cells Amanda Selk (5), Emily Landon (1) Bona Kim (3), Oksana Shynlova (1), Stephen Lye (3) 1A6 - Examining the Forgetting Curve and How it Affects 1B6 - IUGR Phenotype Caused by Acid Surgical Skills Education Sphingomyelinase Deficiency cannot be Brian Liu (1), Patricia Lee (8) Rescued by Normal Uterine Environment Andrea Jurisicova (3), 1A7 - Enhancing Patient Understanding Isidora Rovic (7) of Bladder & Kidney Infection Juliette Dupre (8), Patricia Lee (8)

ANNUAL REPORT 2016/17 57

1B7 - Exercise, Inflammation 1D6 - The Impact of Video-based and Preterm Labor MFM I – Activity Platform on Management Alan Bocking (3), Oksana ePoster Session 1D of Gestational Diabetes – A Shynlova (1), Valerie Steckle (7) Randomized Controlled Trial. 1D1 - Preferences of Pregnant Women Howard Berger (4), Leanne De with and without Epilepsy for Health Souza (4), Nirmala Chandrasekaran Fertility I – States Related to the Use of Anti- (1), Sherri Storm (4) epileptic Medications in Pregnancy ePoster Session 1C Danielle Wuebbolt (1), Esther Bui (2), Hannah Thomas (1), Stem Cells I – 1C1 - Impact of Preimplantation Murray Krahn (2), Rohan D’Souza Genetic Screening on the Rate (5), Vanessa Nguyen (1) ePoster Session 1E of Ultrasound-Detected First Trimester Fetal Anomalies 1D2 - Variation in Preferences 1E1 - Human Umbilical Cord Agata Galewicz-Sojecki (2), Clifford of Pregnant Women with and Perivascular Cells Can Differentiate Librach (1), Julia Brachtchenko (2), without Cardiac Disease for Health Toward a Schwann-like Cell Lineage: Larissa Kan-ool (2), Nikki Legro (2), States Related to the Use of Potential Stem Cell Therapy Ran Antes (2), Sergey Moskovtsev Anticoagulation in Pregnancy for Peripheral Neuropathy (2), Svetlana Madjunkova (2), Candice Silversides (1), Danielle Andree Gauthier-Fisher (2), Clifford Valeriy Kuznyetsov (2) Wuebbolt (1), Hannah Thomas Librach (1), Denis Gallagher (1), Mathew Sermer (1), Murray (2), Fyyaz Siddiqui (2), Jonah 1C2 - Human Pre-implantation Embryos Krahn (2), Rohan D’Souza Librach (2), Luqmaan Moolla Exhibit Morphokinetic and Metabolic (1), Vanessa Nguyen (1) (2), Svetlana Madjunkova (2) Signatures that May Predict Embryo Competency During IVF Treatment 1D3 - Postpartum Depression 1E2 - Scyllo Inositol Does Not Clifford Librach (1), Hanna Assessment in the Multiple Courses Affect Human Umbilical Cord Balakier (1), Parshvi Vyas (7) of Antenatal Corticosteroids Perivascular Cell Biology In Vitro: for Preterm Birth Study Potential for a Combination 1C3 - Evaluation of Dynamic FcR Alison Shea (1), Andrew Willan Therapy for Alzheimer’s Disease Expression Patterns on Human (6), Elizabeth Asztalos (8), Johanna Andree Gauthier-Fisher (2), Bojana Spermatozoa: A Novel Method that Sanchez (8), Kellie Murphy (5) Stefanovic (8), Clifford Librach (1), May Help Determine Optimal Timing Denis Gallagher (2), Fyyaz Siddiqui of Intrauterine Insemination 1D4 - Pregnancy Outcomes in (2), JoAnne McLaurin (8), Luqmaan Annie Qu (1) Patients with Mitochondrial Moolla (2), Lynsie Thomason (8) Myopathy, Encephalomyopathy, 1C4 - Distribution of Funded IVF in Lactic Acidosis and Stroke-like 1E3 - Intra-ovarian Injection of Ontario: A Patient Perspective Episodes (MELAS) Syndrome First Trimester Human Umbilical Claire Jones (1), Tom Gotz (1) Hannah Faghfoury (10), Julia Cord Perivascular Cells Protects Kfouri (1), Rohan D’Souza Against Chemotherapy-induced 1C5 - Neuronal Growth Factors in (1), Serena Gundy (5) Ovarian Damage in Rat Model Human Follicular Fluid and Potential Andree Gauthier-Fisher (2), Correlation with Female Infertility 1D5 - Predicting Pregnancy Clifford Librach (1), Karen Glass Amanda Baillargeon (2), Andree Outcomes and Time-to-Transfusion in (8), Khaled Zohni (1), Lianet Gauthier-Fisher (2), Brandon Wyse Isoimmunized Pregnancies that Require Lopez (11), Meredith Garcia (2) (2), Clifford Librach (1), Khaled Fetal Intrauterine Blood Transfusion Zohni (1), Miranda Defer (2), Gareth Seaward (1), Greg Ryan 1E4 - Progesterone enhances Mozhgan Naeini (1), Mugundhine (1), John Snelgrove (1), Nadine immunoprivilege of first TM human Sangaralingam (2), Prati Sharma (1) Shehata (2), Rohan D’Souza umbilical cord perivascular cells (5), Rory Windrim (1) (FTM-HUCPVCs): a new way to improve therapeutic engraftment

58 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY 34th Annual Research Day

Alexandra Lucato (2), Andree Li (2), Natalia Yasovich (2), 1G3 - TNFα Exposure Induces Gauthier-Fisher (2), Benjamin Noga Weizman (1), Ran Antes Neuroinflammation and Insulin Katzman (2), Clifford Librach (2), Valeriy Kuznyetsov (2) Resistance in a Rat-derived (1), David Rabinovitch (2), Peter Hypothalamic Cell Model, rHypoE-7 Szaraz (7), Yarden Gratch (2) 1F4 - Differentiating Induced Denise Belsham (7), Leigh Pluripotent Stem Cells into Wellhauser (7), Makram Aljghami 1E5 - Human Umbilical Cord Renal Progenitors for Reseeding (7), Matthew Clemenzi (7) Perivascular Cells (HUCPVC) Maintain onto Decellularized Scaffolds Mesenchymal Stromal Characteristics of the Porcine Kidney 1G4 - VEPH1 Decreases TSC1: A & Regenerative Properties after Aisha Mohamed (7), Ian Rogers Potential Modulation of mTOR Signalling Chemotherapy Exposure (1), Jennifer Whiteley (1), Markus Alexandra Kollara (1), Premalatha Andree Gauthier-Fisher (2), Selzner (10), Matyas Hamar Shathasivam (1), Suan Chin Yeo Brandon Wyse (2), Clifford Librach (2), Moritz Kaths (10), Theresa (7), Theodore Brown (1) (1), Itai Gat (1), Karen Glass (8), Chow (7), Tonya Bongolan (7) Khaled Zohni (1), Lianet Lopez 1G5 - Optimizing a Procedure (11), Melissa Filice (2), Meredith 1F5 - Generation and Characterization for the Isolation and Purification Garcia (2), Peter Szaraz (7) of Induced Pluripotent Stem Cells of Human Granulosa Cells for (iPSCs) from Human Umbilical Cord Biobanking Purposes. Mesenchymal Stromal Cells Using Andree Gauthier-Fisher (2), Stem Cells II – Episomal 5 Reprogramming Brandon Wyse (2), Clifford Librach Aisha Mohamed (7), Ian Rogers (1), Mozhgan Naeini (1), Shlomit ePoster Session 1F (1), Jennifer Whiteley (1), Theresa Kenigsberg (2), Sydney Flatt (2) Chow (7), Tonya Bongolan (7) 1F1 - Optimizing Cell Expansion for Regenerative Therapy to Gynaecology I – Maintain the Phenotype of First Reproductive Trimester Human Umbilical Cord ePoster Session 1H Perivascular Cells (FTM-HUCPVCs) Endocrinology I – Alexandra Lucato (2), Benjamin ePoster Session 1G 1H1 - Factors Influencing the Katzman (2), Clifford Librach Difficulty of Laparoscopic (1), Corey Kamen (2), David Myomectomy: A Delphi Approach Yanofsky (2), Peter Szaraz 1G1 - The Cumulus Cell Transcriptome Ally Murji (5), Catherine Allaire (2), Yarden Gratch (2) is Profoundly Influenced by the Method (2), Eliane Shore (4), John Thiel for Triggering of Final Maturation in IVF (2), Marian Leung (1), Sukhbir 1F2 - A Novel Method to Calculate Patients With a High Ovarian Reserve Singh (2), Togas Tulandi (2) the Mitochondrial DNA/Nuclear Brandon Wyse (2), Clifford Librach (1), Hanna Balakier (1), Itai Gat DNA Ratio in Human Blastocysts 1H2 - Measure to Reduce Peri- as a Biomarker for Human (1), Julieta Caballero (2), Noga Fuchs Weizman (1), Shlomit and Intra-Operative Blood Loss Embryo Implantation Potential Kenigsberg (2), Stewart Russell (2) at Myomectomy: A Survey of Clifford Librach (1), Ely Fish Obstetrician-Gynecologists (2), Jonah Librach (2), Ran 1G2 - Alterations in Neuroinflammatory Deborah Robertson (1), Grace Yeung Antes (2), Rina Abramov (1), (1), Helena Frecker (1), Sari Kives (4) Svetlana Madjunkova (2), Cytokines in Co-culture of Valeriy Kuznyetsov (2) Hypothalamic Neurons and 1H3 - Gabapentin Reduces Opioid Microglia Exposed to Palmitate Use Postoperatively (“GROUP 1F3 - Sperm DNA Fragmentation Index Denise Belsham (7), Jennifer Study”): A Randomized Control (DFI) Does Not Correlate With Blastocyst Chalmers (7), Mun Huei Trial in Women Undergoing Aneuploidy Rate in Egg Donor Cycles Kim (7), Soyeon Park (7) Reconstructive Pelvic Surgery Clifford Librach (1), Itai Gat Adrienne Li (1), Colleen (1), Khaled Zohni (1), Nancy McDermott (1), Danny Lovatsis

ANNUAL REPORT 2016/17 59

(1), Kristin Wadsworth (5), May Sqapi (7), Robert Levitan (2), 2B1 - Twice-daily vs. Four- Alarab (1), Naveed Siddiqui Stephen Matthews (7) times Daily Glucose Testing (5), Nucelio Lemos (5) in Women with Gestational 2A2 - Fetal Glucocorticoid Diabetes Mellitus: Pilot Study 1H4 - A Cost-utility Analysis of Exposure Modifies the Blood- Alison Park (4), Howard Non-surgical Treatments for the Brain Barrier After Birth Berger (4), Joel Ray (4), Management of Stress Urinary Margaret Eng (7), Stephen Sophie Bussiere-Cote (1) Incontinence in Adult Women Matthews (7) Alaina Garbens (2), Andrea 2B2 - Rates of Gonorrhea and Simpson (1), Colleen McDermott 2A3 - The Effect of the Endocrine Chlamydia Testing Among Pregnant (1), Fahima Dossa (2), Nancy Disrupting Chemical Bisphenol A Women Presenting for Prenatal Care Baxter (4), Peter Coyte (2) on Pro-opiomelanocortin, Circadian Marina Vainder (1), Mark Rhythm, and Neuroinflammatory Yudin (1), Sari Kives (4) 1H5 - A Novel Approach to Marker Gene Expression Postoperative Pain Management Ashkan Salehi (7), 2B3 - Pregnancy Outcomes Following in Vaginal Surgery: Bupivacaine Denise Belsham (7) Ulipristal Acetate Treatment for Uterine Use in Vaginal Packing Fibroids: A Systematic Review and Amanda Michael (1), Janet 2A4 - The Effect of Bisphenol A Multi-Center Canadian Case Series Bodley (1), Louise Gagnon (8), and Bisphenol S on Hypothalamic Ally Murji (5), Angelo Vilos (2), Patricia Lee (8), Rose Kung (1) Feeding-Related NPY/AgRP Neurons Cassandra De Gasperis-Brigante (1), Denise Belsham (7), Emma George Vilos (2), Sukhbir Singh (2) 1H6 - Operating Room Utilization: A McIlwraith (7), Neruja Retrospective Analysis of Operating Loganathan (7) 2B4 - Iron Deficiency Anaemia in Room Delays by Hysterectomy Approach Pregnancy and Treatment Options: Andrea Simpson (1), Eliane 2A5 - Antenatal Glucocorticoid A Patient-preference Study Shore (4), Grace Yeung (1) Therapy and Oxidative Stress Danielle Wuebbolt (1), Hannah in the Fetal Hippocampus Thomas (1), Murray Krahn (2), 1H7 - The Incidence and Risk Alexandros Mouratidis (7), Nadine Shehata (2), Rohan Factors for Pregnancy Among HIV- Alisa Kostaki (7), Stephen D’Souza (5), Vanessa Nguyen (1) positive Adolescents Enrolled in a Matthews (7), Susmita Sarkar Large HIV Treatment Program in (7), Vasilis Moisiadis (7) 2B5 - Finding an Objective Method of Western Kenya from 2005–2014 Estimating Intrapartum Blood Loss Alfred Keter (2), Alice Kaaria (2), 2A6 - Novel Approaches to Investigate Adam Komorowski (2), Adam Rosen Edith Apondi (2), Gerald Bove (2), the Developing Blood-brain Barrier (1), Kristyn Dunlop (2), Rebecca Heather Millar (1), Juddy Wachira Andrada Naghi (7), Margaret Eckler (2), Rohan D’Souza (5) (2), Katherine MacDonald (2), Paula Eng (7), Stephen Matthews (7) Braitstein (2), Rachel Spitzer (1) 2B6 - Optimal Timing of Antenatal 2A7 - Predictive Modelling of Corticosteroids in Women with Behaviour through Gene Expression Bleeding Placenta Previa Alisa Kostaki (7), Andrea Eman Alsayegh (1), Jon Barrett Developmental Constantinof (7), Stephen Matthews (8), Nir Melamed (8) Origins of Health (7), Vasilis Moisiadis (7) 2B7 - Late-Preterm Twins – Are They & Disease – Facing the Same Risks as Singletons? ePoster Session 2A Elizabeth Asztalos (8), Jon Barrett Obstetrics II – (8), Mia Kibel (8), Nir Melamed 2A1 - Placenta-derived Serotonin in ePoster Session 2B (8), Shimrit Yaniv Salem(1) Highly Seasonal Pregnant Women Alan Bocking (1), Maria

60 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY 34th Annual Research Day

Fertility II – 2D2 - Role of Angiomotin (AMOT) in Mileikovsky (3), Maria Shutova TGF-β Mediated Disruption of Cell (3), Marina Gertsenstein (2), ePoster Session 2C Polarity in the Human Placenta Puzheng Zhang (3), Qin Liang Abby Farrell (3), Isabella Caniggia (3) (3), Sabiha Hacibekiroglu (3) 2C1 - Is Cost a Barrier? Fertility Preservation Utilization Among 2D3 - Cross-talk Between Oxygen and 2E3 - Development of Local Acting Oncofertility Patients Sphingolipid Metabolism in Human Biologics for Combined Cell and Gene Eileen McMahon (5), Ellen and Murine Placental Development Therapy to Treat Rheumatoid Arthritis Greenblatt (1), Tom Gotz (1) Isabella Caniggia (3), Julien Sallais (3) Andras Nagy (1), Eric Neely (3)

2C2 - Application of the haloFISH 2D4 - A Single Sphingomyelin 2E4 - Systemic and Local Modulation Assay to Distinguish Chromosomal Species Promotes Exosomal Release of the Immune Response to (Chr) and Extrachromosomal of Endoglin into the Maternal Allogeneic Cell Transplants (EC) Telomeric DNA Populations Circulation in Preeclampsia Andras Nagy (1), Huijuan Yang (3), Ian Rogers (1) in the Human Sperm Genome Isabella Caniggia (3), Leonardo Clifford Librach (1), Martin Komosa Ermini (1), Martin Post (6), (6), Pamela Kurjanowicz (7), Sergey Cynthia Maxwell (5), James Moskovtsev (2), Uri Tabori (6) Vernon (2), John Snelgrove (1), Rohan D’Souza (5), Yair Sagi (1) Gynaecology 2C3 - Effect of the Density Gradient Oncology – Centrifugation Sperm Isolation Method 2D5 - Wound Disruption ePoster Session 2F on Human Sperm DNA Damage Following Caesarean Delivery in Andrew Lee (1), Bill Yee (7), Clifford Women with Class III Obesity: A 2F1 - VEPH1 Expression Decreases Librach (1), Junyan Zhang (1), retrospective Case Control Study Vascularization in Ovarian Cancer Kirah Hahn (2), Natalia Yasovich Elad Mei-Dan (12), Jon (2), Sergey Moskovtsev (2) Barrett (8), Nir Melamed Xenografts and Inhibits VEGFA (8), Rebecca Jackson (1) and IL8 Expression through 2C4 - Laboratory and Clinical Inhibition of AKT Activation Outcomes of Intracytoplasmic 2D6 - Placental Location Alexandra Kollara (1), Blaise Clarke (10), Maurice Ringuette Sperm Injection Cycles Utilizing and Preterm Birth (2), Premalatha Shathasivam (1), Elad Mei-Dan (12), Jon Sperm Obtained by Microsurgical Soyeon Park (7), Theodore Brown Barrett (8), Nir Melamed Testicular Sperm Extraction (1), Thomasina Spybey (7) Ellen Greenblatt (1), Jason (8), Rebecca Jackson (1) Elliott (1), Keith Jarvi (5) 2F2 - The Feasibility of Laparoscopic Surgery in Gynaecologic Oncology Stem Cells III – for Obese and Very Obese Patients MFM II – Jessie Peng (1), K. Joan Murphy ePoster Session 2E (9), Kate Pulman (1), Sarah Sinasac ePoster Session 2DI (9), Tomer Feigenberg (1) 2E1 - Transient Human Trophoblast 2D1 - Screening Healthy Nulliparous Populations Identified through 2F3 - Hematologic Toxicity in Women for Placental Disease Cellular Systems Biology Women with BRCA Germline in the Second Trimester Brian Cox (7), Frances Wong (7) Mutation Undergoing Platinum- Barry Hoffman (5), Emily based Chemotherapy for High-grade Wright (1), John Kingdom (1), 2E2 - Defining and Providing a Serous Ovarian Carcinoma Melanie Audette (1), Prakesh Solution for Cell Therapy Safety Jeffrey Boyd (2), Joanne Kotsopulos Shah (5), Sarah Keating (2), Andras Nagy (1), Claudio (11), Karla Willows (1), Marcus Stephen Lye (3) Xiang Ye (5) Monetti (3), Eric Neely (3), Bernardini (1), Ping Sun (11), Hoon-Ki Sung (6), Huijuan Yang (3), Iacovos Michael (3), Maria

ANNUAL REPORT 2016/17 61

Raymond Kim (10), Steven Receptor Antagonist to Induce Amanda Selk (5), Michal Sheinis (1) Narod (11), Taymaa May (1) Ovulation: A Forgotten Treatment? Jigal Haas (1), Rawad Bassil 2H3 - Efficacy and Safety of 2F4 - Impact of Surgical Stress on (1), Robert Casper (1) Transdermal Estrogen and Intermittent Advanced Ovarian Cancer Progression Progesterone: A Retrospective Study and Survival in Relation with Timing 2G3 - Plasminogen Activator Halaa Gomaa (1), Lina Huang of Chemotherapy: Bedside to Bench Inhibitor-1 (PAI-1) in Peritoneal (1), Namshah Alburiki (1), Alexandra Kollara (1), Austin Yoo Fluid of Endometriosis Patients Wendy Wolfman (1) Lee (1), Lin Lu (10), Taymaa May (1), Dan Nayot (1), Paul Chang Theodore Brown (1), Wei Xu (10) (1), Robert Casper (1), 2H4 - Selective Progesterone Receptor Tzu-Bou Hsieh (1) Modulators (SPRMs) for Uterine 2F5 - A Decision Analysis of the Fibroids – A Cochrane Review Treatment Strategies for Pelvic Lymph 2G4 - Progesterone Differentially Ally Murji (5), Mara Sobel Node Positive Stage IB1 Cervical Cancer Regulates Cx43 Gap Junction (5), Tiffany Chow (1) Harindra Wijeysundera (2), Harry Formation through its Receptors PRA Brar (1), Nadia Roumeliotis (6), and PRB in Breast Cancer Cells 2H5 - Bacterial Vaginosis in the Sarah Ferguson (1), Tiffany Zigras (1) Justin Rondeau (7), Lubna Pregnant Adolescent Population: Nadeem (3), tephen Lye (3) Screening and Treatment in a Dedicated 2F6 - Sentinel Lymph Nodes Adolescent Prenatal Program in Vulvar Cancer: Management 2G5 - Regulation of the Novel Anjali Aggarwal (1), Carol King (6), Dilemmas in Patients with Positive Reproductive Peptide, Phoenixin, Hanna Goldberg (1), Lauren Jain (1), Nodes and Larger Tumors by Bisphenol A and Palmitate, Lisa Allen (5), Rachel Spitzer (1) Allan Covens (1), Andra Nica (1), but not 17β-Estradiol, in Danielle Vicus (1), Lilian Gien Hypothalamic Cell Models 2H6 - Impact of Introducing an (1), Matthew Cesari (8), Rachel Denise Belsham (7), Emma Evidence-based Multidisciplinary Kupets (1), Ray Osborne (1) McIlwraith (7), Neruja Algorithm on the Management Loganathan (7) of Adnexal Masses in the 2F7 - Sites of Recurrence and Paediatric Population Their Impact on Post-recurrence 2G6 - Effects of the Saturated Hanna Goldberg (1), Lisa Survival in Patients with Ovarian Fatty Acid Palmitate on Cellular Allen (5), Sari Kives (4) Clear Cell Carcinoma Neuroinflammation and Pomc Liat Hogen (1) Expression in the mHypoA-POMC/ 2H7 - Registrar and Consultant GFP Neuronal Cell Models Perceptions of a 24-Hour Obstetrical Denise Belsham (7), Erika Tse (7) Call Schedule at a Teaching and Reproductive Referral Hospital in Eldoret, Kenya Astrid Christoffersen-Deb (1), Endocrinology II – Bett Kipchumba (2), Elkanah ePoster Session 2G Gynaecology II – Omenge (2), Heather Millar (1), ePoster Session 2H Joy Alera (2), Martha Smith (2) 2G1 - PRA and ERα Jointly Transform Quiescent Pregnant 2H1 - Surgical Management Algorithm Myometrium into a Contraction for Caesarean Scar Pregnancy Generating Muscle During Labour Ally Murji (5), Jessica Papillon- Smith (5), Jonathon Solnik (5), Hedy Romero (2), Lubna Nadeem Kirsten Niles (5), Mara Sobel (5) (3), Oksana Shynlova (1), Sam Mesiano (2), Stephen Lye (3) 2H2 - Development of the Adult 2G2 - A Case Report – Treatment Vulvar Lichen Sclerosus Severity of Hypo Hypo Patients with Opioid Scale – A Delphi Consensus Exercise

62 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY 34th Annual Research Day

J.W. Knox Ritchie Research Awards

We are pleased to announce the following winners of the 2017 J.W. Knox Ritchie Research Awards for best abstract/ presentation by trainee category.

Clinical Fellow John Snelgrove (Supervisor: Astrid Christoffersen-Deb) Increasing Pregnancy Health Services Uptake through Integrated Peer Support Groups in Kenya: A Prospective Cohort Study

Post-Doctoral Fellow Lubna Nadeem (Supervisor: Stephen Lye) PRA and ERα Jointly Transform Quiescent Pregnant Myometrium into a Contraction Generating Muscle During Labour

Resident Maria Cusimano (Supervisor: Sarah Ferguson) Prospective Validation of Sentinel Lymph Node Biopsy with Indocyanine Green Flourescence Imagine in High- grade Endometrial Cancer

Graduate Student Abby Farrell (Supervisor: Isabella Caniggia) Role of Angiomotin (AMOT) in TGF-β Mediated Disruption of Cell Polarity in the Human Placenta

Medical/Undergraduate Student Ana-Maria Iancu (Supervisor: Eliane Shore) Modelling the Learning Curves of Incoming Surgical Trainees

ANNUAL REPORT 2016/17 63 FACULTY PROFESSIONAL DEVELOPMENT DAY 2016

The theme for Faculty Professional Development Overall Goal Day for 2016 was faculty mentorship and wellness. To encourage faculty mentorship and wellness by The event was held at the Vaughan Estate at the presenting current knowledge, skills and strategies Estates of Sunnybrook on Friday, November 11th, on the effective management of stress related to 2016. There were over 90 faculty members in clinically challenging events, the achievement of attendance. The theme of faculty mentorship and desired career goals through genuine mentorship wellness was explored through a collection of small support, and the development of a sense of personal group interactive sessions, plenary and keynote fulfillment and meaning in one’s work and life. lectures, and participant-led discussion groups (“unconference” sessions). Topics included peak Program Objectives performance and mental readiness, intentional role- After participation in this program, faculty members modelling, mindfulness in life and medical practice, would be able to: mitigating risk and managing stress during disclosure 1. Describe skills to improve mental readiness and of healthcare-related harm, mentorship in clinical achieve peak performance in medical practice. and research environments, ethics of authorship, 2. Use intentional role modelling to support the sleep health, late career transitions, and thriving in competency by design framework. academic medicine. 3. Apply principles of mindfulness to enhance professional practice and personal well-being.

64 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY FACULTY PROFESSIONAL DEVELOPMENT DAY 2016

4. Explain ways to manage stress brought on by • Staying Out of Trouble (When You’re in Trouble), patient harm and medico-legal difficulties. facilitated by Tino Piscione, CMPA 5. Identify principles of establishing a mentorship • Trials and Tribulations of Authorship, facilitated by program in the Department. Ted Brown 6. Examine impact of sleep loss on health and patient care, and sleep loss compensation. Other small group session topics were: 7. Identify late career transition phenomenon and • Peak Performance: Staying on Top of Your Game – how stakeholders can take action for success. with Ted Bober and Joy Albuquerque from the 8. Discuss effective mentorship, for mentors and OMA Physician Health Program mentees, in clinical and research spheres. • Role Modelling: Actions Speak Louder Than Words! 9. Discuss the ethics of research authorship. Enhancing the Use of Intentional Role Modelling 10. Define “success” in academic medicine and how in Teaching and Learning – with Janet Bodley, faculty can “thrive” in the academic culture. Department of Obstetrics & Gynaecology • The Mindful OBGYN: Using Mindfulness in Life The plenary opening lecture was provided by and Medical Practice – led by Steven Selchen, Dr. Brian Murray, an associate professor at the Department of Psychiatry University of Toronto in neurology and director of • When Things Go Wrong: What are our Obligations the sleep laboratory at Sunnybrook Health Sciences to the Patient, and to Ourselves? – led by Tino Centre. Dr. Murray presented, Sleep: Your Health and Piscione, CMPA Clinical Practice. The presentation addressed the basic • Late Career Transition: What, Why, and How? – principles of sleep physiology, the effects of sleep loss led by Robin Richards, Department of on health and the impact it has on patient care, and Surgery, SHSC strategies to compensate for sleep loss. • Mentorship Essentials – led by Karen Leslie, Centre for Faculty Development The keynote lecture was presented by Dr. Karen • Supervising and Mentoring Graduate Research Leslie. Dr. Leslie is a staff paediatrician in the Trainees: How to Foster a Working Knowledge of Division of Adolescent Medicine at the Hospital Research – led by Ted Brown, Department of for Sick Children and a Professor of Paediatrics at Obstetrics & Gynaecology the University of Toronto. Since 2009, Dr. Leslie has been the Director of the Centre for Faculty Development. Her presentation looked at how faculty ensure that academic careers are both successful and fulfilling and how various roles academic faculty play as clinicians, educators, and researchers, are valued and supported.

This year, the organizing committee introduced a series of “unconference” sessions which were less structured small group sessions to allow for more dynamic discussion. Unconference session topics included:

• Establishing a Formal Mentorship Program in the Department of Obstetrics & Gynaecology, facilitated by Janet Bodley and Karen Leslie

ANNUAL REPORT 2016/17 65 GRADUATION CEREMONY & ALUMNI EVENT

2016–2017 Graduating Class Resident Awards

The Graduation Ceremony & Alumni Event continues to be our most Social Responsibility Award highly attended and exciting event of the year. We gathered at the in Global Women’s Health and University’s Hart House in the Great Hall which highlights the prestige Vulnerable Populations of our program and its graduates. At this year’s ceremony, we had the Rebecca Rich past 3 department chairs, Drs. Alan Bocking, Knox Ritchie, and Walter Hannah, in attendance along with Dr. Bill Whittaker, one of the oldest Excellence in Clerkship Teaching residency training program graduates, who was from the graduating • Maria Cusimano (PGY3) class of 1959. Dr. Alan Bocking addressed the graduates and also • Kristin Harris (PGY4) honoured Dr. Donna Steele, the departing Residency Program Director, • Lynn Sterling & Mathew on behalf of the Department, with his words of praise for her work and Leonardi (PGY5) dedication to building the program and for the care she showed the residents who went through the program. Society of Maternal-Fetal Medicine Resident Award for Excellence in Obstetrics Graduating Residents 2017 Kirsten Niles

Marie Christakis Julie Nyugen American Association of Lara Gotha Kirsten Niles Gynaecologic Laparoscopists Lacey Harding Rebecca Rich (AAGL) Award John Ibrahim Aparna Sarangapani Aparna Sarangapani Ingrid Lai Lynn Sterling Mathew Leonardi Marta Wais North American Society for Carmen McCaffrey Jellena Wong Pediatric and Adolescent Gynecology (NASPAG) We hope that our graduates will continue to stay in touch and even Outstanding Resident Award be involved with our Department as they proceed onto new Lacey Harding endeavours in their careers. As always, we look forward to their great accomplishments to come. Dr. Frederick R. Papsin Award Carmen McCaffrey

66 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY GRADUATION CEREMONY & ALUMNI EVENT

Faculty Awards Gynaecologic Oncology* Perinatal Harinder Brar Gharid Nourallah Bekdache Nili Isserles CREOG National Faculty Award Maternal-Fetal Medicine* Gabrielle Cassir Mara Sobel Nirmala Chandrasekaran Shimrit Yaniv Salem Reproductive Sciences Neelam Sierra Resident Yair Sagi Tzu-Bou Hsieh Advocacy Award Stefania Ronzoni Jigal Haas Donna Steele Hana Alsehli Genevieve Genest Rasheeda Al Tourshi Reproductive Sciences & Infertility Graduating Mature Women’s Health Khalid Zohni Fellows 2017 & Menopause Lina Huang Urogynaecology & Reconstructive Advanced High Risk Obstetrics Pelvic Surgery Yael Ganor Minimally Invasive Andrea Santiago Dana Vitnor Gynaecologic Surgery** Brian Liu Global Women’s Health & Equity Advanced Obstetrics Heather Millar Maayan Bas-Lando Minimally Invasive Gynaecologic Surgery – SMH * Royal College of Physicians Gynaecologic Reproductive Grace Yeung and Surgeons of Canada Endocrinology & Infertility* Aisha Yousuf accredited program Jason Elliott ** American Association of Paediatric & Adolescent Tamas Gotz Gynaecologic Laparoscopists Gynaecology accredited program Gynaecologic Endoscopic Surgery Carol King Vicky Hadid

ANNUAL REPORT 2016/17 67 SIGNIFICANT HONOURS & AWARDS

2016–2017 Department Awards

Chair’s Awards

Excellence in Undergraduate Teaching Dini Hui

Excellence in Postgraduate Teaching Mark Yudin

Excellence in Integrated Undergraduate Teaching Kooyeon Chun

Excellence in Integrated Postgraduate Teaching Anjali Aggarwal

Excellence in Postgraduate Program Development/Innovation Tatiana Freire-Lizama

Outstanding Research Potential Mount Sinai Hospital Danielle Vicus Awards for Undergraduate Teaching Excellence Lindsay Shirreff Sustained Excellence in Research North York General Hospital Andras Nagy Brampton Civic Hospital Kiran Sahi Lynne Zolis Excellence in Research Facilitation Sunnybrook Health Sciences Centre Eliane Shore Credit Valley Hospital Amanda Cipolla Dini Hui Excellence in Continuing Medical St. Joseph’s Health Centre Education Teaching Etobicoke General Hospital Clarissa Bambao Michael Shier Rebecca Cash St. Michael’s Hospital Excellence in Continuing Medical Michael Garron Hospital Eva Mocarski Education Course Coordination Anjali Aggarwal Rachel Spitzer & Lisa Allen Mississauga Hospital The Scarborough Hospital Dalip Bhangu Haidar Mahmoud

Mount Sinai Hospital Carl Nimrod Award Ally Murji Melanie Ornstein

68 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Research Grants & Investigations

ANNUAL REPORT 2016/17 69 PEER-REVIEWED GRANTS

in Regulating Sphingolipid Metabolism during Placental Development. Natural Sciences and Engineering Research Council (NSERC), Discovery Grant. $150,000 CAD. April 2015 – March 2021.

Caniggia I (PI), Nevo O, Post M. The Role of Bcl-2 Family Members in Regulating Placental Cell Fate. Canadian Institutes of Health Research (CIHR), Operating Grant. $795,820 CAD. April 2014 – March 2019.

Caniggia I (PI), Post M, Ermini L, Bocking A, Lye S. Lipidomics: A Novel Tool to Define Human Placental Development and Function across Pregnancy. National Institutes of Health (NIH) RFA-HD-16-036 Using Omics to Define Human Placental Over $10,000 Greenblatt E. Sustained Development and Function PI=Principal Investigator Ovulation-associated Across Pregnancy (R01) Signaling in Fallopian Tube grant. $1,918,737 USD. Epithelium as a Predisposing Baker A, Librach CL Toronto Gynecologic Surgery September 2016 – July 2021. Factor of Serous Carcinoma. (Co-PI). Human Umbilical Video Repository (TVSRR) – A Operating Grant (Renewal Cord Perivascular Cell Novel Approach to Surgical Casper R (PI), Juriscova A of MOP106679) – Canadian (HUCPVC) Therapy for Education. Sinai Health System. (Co-PI). Characterization of the Institutes of Health Research Traumatic Brain Injury: Department of Obstetrics and Bioenergetics and Metabolic (CIHR). $495,000 CAD. October Targeting the Neurovascular Gynecology. $10,000 CAD. Function of Mitchondria 2013 – September 2016. Unit. Physicians Services March 2016 – February 2017. Isolated from Oocyte Precursor Stem Cells. CIHR, Operating Incorporated (PSI). $160,500 Bujold E (PI), Audibert F, Brown TJ (PI), Ringuette M. Grant: Industry-Partnered CAD. June 2015 – May 2017. Pastuck M, Chaillet N, Okun Impact of VEPH1 on Cancer Collaborative Research. N, Forest JC, Giguere Y, Masse Berger H (Co-PI), Feig D Associated Signalling Pathways $911,700 CAD. March B. First-trimester Prediction (Co-PI), Lipscombe L (Co-PI), in the Promotion of Ovarian 2015 – February 2020. of Preeclampsia and Other Bocking A, Birken C, Maguire J, Cancer. Transitional Operating Planceta-mediated Pregnancy Halperin I, Mukerji G, Melamed Grant - Canadian Institutes Dennis CL (lead) Birken C (PI), Complications. Department N, Wolfs M. BBDC Diabetes of Health Research (CIHR). Abbass-Dick J, Atkinson S, of Obstetrics & Gynaecology, in Pregnancy Cohort Study. $761,655 CAD. September Barrett J, Bell R, Berard A, Mount Sinai Hospital. CHIR Banting and Best Diabetes 2015 – August 2020. Berger H, Brown H, Chambers Grant. $979,574 CAD. Centre. $247,208.05 CAD. C, Clinton J, Constantin E, Da Brown TJ, Rosen B (PIs); July 2016 – June 2021. April 2015 – March 2017. Costa D, Feller, Guttmann A, Murphy KJ, Colgan T, Tone Hutchinson H, Isaranuwatchai Caniggia I (PI). The Dynamic Bernardini MQ (PI), Brar H. A, Virtanen C, Allen L, W, Janus M, Joseph KS, Role of the Oxygen/TGFß Axis

70 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY PEER-REVIEWED GRANTS

Kimmins S, Letourneau N, Feig D (PI), Asztalos E, Corcoy Maximizing Cancer Prevention $3,400,000 USD. 2017–2023. Li P, Maguire J, Manson H, G, Donovan L, Hod M, Jovanovic through Universal Screening Ganea P (PI), Kingdom JC, McGrath P, Murphy KE, Nuyt L, Keely E, Kollman C, Kowalski for Lynch Syndrome in Shah P. Placental Health AM, O’Connor D, Parekh R, A, Lou O, de Levia A, McManus Women with Endometrial Predictors of Cognitive Paterson A, Parkin P, Puts M, R, Murphy H, Murphy KE, and Non-Serous Ovarian Outcomes in Early Childhood. J. Ray J, Roumeliotis P, Santos R, Pragnell M, Ruedy K, Tomlinson Cancer. Canadian Cancer P. Bickell Foundation. $65,000 Scherer S, Sellen D, Semenic G, Yogev Y. Continuous Monitor Society Research Institute CAD. July 2015 – June 2017. S, Shah P, Smith G, Stremler Glucose Monitoring in Women (CCSRI) Prevention Grant. R, Szatmari P, Telner D, Thorpe with Type 1 Diabetes in $592,718 CAD. 2015–2019. Ganea P (PI), Kingdom K, Tremblay M, Vigod S, Pregnancy Trial (CONCEPTT). JC, Shah P, Lee K, Jenkins Ferguson S (PI), Classen C Walker MP. Juni Trajectories Juvenile Diabetes Research J, Doesburg S, Miller S, (PI), Barbera L, Chivers M, of Healthy Life Using Public Foundation International and Chau V, Akbari E. Placental Urowitz S, Wiljer D. An Online Health and Primary Care Juvenile Diabetes Research Health Predictors of Brain Support Group for Sexual Interventions in Canada: The Foundation Canada. $7,121,042 Development and Cognitive Distress Due to Gynaecologic TROPHIC Trial. Canadian CAD. July 2012 – June 2016. Outcomes in Early Childhood. Cancer: A Randomized Study. Institutes of Health Research Fraser Mustard Institute Ferguson S (PI), Bernardini Canadian Institutes of Health (CIHR). $17,050,000.00 CAD. for Human Development MQ, Butler M, Clarke B, Brown Research (CIHR). $827,860 August 2017 – July 2027. and OISE. $10,000 CAD. T, Tone A, Virtanen C, Pugh T, CAD. July 2011 – July 2016. July 2015 – June 2017. D’Souza R (PI), Murphy KE, Vicus D, Eriksson L, McGill P, Fortier I, Atkinson S, Bocking Alavifard S. Determining the Kwon J, Ohashi, P. Targeting Gien LT (PI), Barbera L, A, Junker A, Ferretti V, Fraser Success of Induction of Labour: the Immune Microenvironment Kupets R. Merit Award W, Doiron D. Research A Prediction Rule. MSH- of Microsatellite Instable for The GHROW Program Advancement through Cohort OBGYN Department grants. Non-serous Ovarian – Gynecologic Oncology Cataloging and Harmonization $11,242 CAD. February 2017. Carcinoma. Canadian Cancer Health Services Research for (ReACH). CIHR. $1,300,000 Society Research Institute Women. University of Toronto, Fehlings M (PI), Nagy A, CAD. 2016–2021. (CCSRI) Innovation Grant. Department of Obstetrics & Morshead C, Shoichet M, Tator $199,306 CAD. October Fowler R (PI), Aoyama K, Gynecology. $80,000 CAD. C, van der Kooy D. Repari and 2016 – October 2018. Hladunewich M, Lapinsky July 2016 – June 2018. Regeneration of the Injured S, Ray J, Scales D, Shah P, Cervical Spinal Cord: An Ferguson S (PI); Brown Greenblatt E, Liu K. Expanding Seward G, Shah P. Regional Integrated Translationally T, Butler M, Clarke B, Urgent Oncofertility Services and Temporal Variations Oriented Team Grant. Krembil Eiriksson L, Kwon J, Ohashi for Reproductive-aged Women in Incidence, Prevalence, Foundation Grant, University P, Pugh T, Tone A, Vicus D, at Cancer Centres Remote and Outcomes of Critical Health Network. $206,000 Virtanen C. Targeting the from a Tertiary Level ART Illness among Pregnant and CAD. May 2015 – April 2018. Immune Microenvironment Centre by use of Telehealth and Postpartum Women and of Microsatellite Instable an On-site Nurse Navigator. Feig D (PI), Armson BA, Newborns in Canada. CIHR, Non-serous Ovarian Carcinoma. AHSC AFP Innovation Fund, Asztalos E, Fantus IG, Canadian Institute for Health Innovation Grant, Canadian Ministry of Health of Ontario. Hamilton JK, Haqq AM, Lee Research. $41,325 CAD. Cancer Society Research $76,600 CAD. 2015–2017. SK, Lipscombe L, Murphy KE, July 2015 – June 2016. Institute (CCSRI). $199,306 Ohlsson A, Ryan EA, Tomlinson Jumah NA. Addressing CAD. June 2016 – July 2018. Frazier L (Co-PI), Covens A GA, Zinaman B. MiTy Kids: Transitions in Care: An (Co-PI). A Phase 3 Study of Metformin in Women with Type Ferguson S (PI), Clarke B (PI), Indigenous-based, Integrated Active Surveillance for Low 2 Diabetes in Pregnancy Kids Gallinger S, Holter S, Pollett Care Pathway for Opioid Risk and a Randomized Trial Trials. Canadian Institutes A, Vicus D, Kwon J, Eiriksson Dependence in Pregnancy of Carboplatin vs. Cisplatin of Health Research, Clinical L, Read C, Bernardini MQ, in Northwestern Ontario. for Standard Risk Pediatric Trial. $1,299,000 CAD. October Gilks C, Dube V, Aronson M, $500,000 CAD. January and Adult Patients with Germ 2012 – September 2018. Lerner-Elis J, Pugh T, Tone 2017 – December 2020. Cell Tumours. NCI (CTEP). A, Hart T, Kim R, McGill P.

ANNUAL REPORT 2016/17 71

Jumah NA (PI), Richardson Kimmins S, Lambrot R, Weiler A, Benard D. Generation of Cancer Care Ontario. $35,000 L, Wanakamik Y, T Armstrong H, Librach CL, Moskovtsev Sex-specific Effects of Paternal CAD. December 2016. T. Hearing Our Voices: SI, Dodds L, Bale T, Fishman J, Environmental Exposures Laflamme M (PI),Nagy A, An Indigenous Women’s Bailey J, Trasler J, MacFarlane on Offspring Development Keller G, Cheng HL. Improving Reproductive Health A, Didier R, Jainguo X, DeJager Health. Canadian Institute the Function, Integration and Curriculum. Northern T, Aneck-Hahn N, Bornman of Health Research (CIHR), Safety of Stem Cell-derived Ontario Academic Medical R, MacIntyre U, Peters A, Grant. $1,500,000 CAD. Cardiomyocyte Transplantation. Association. $50,000. Benard D. CIHR Team Grant: July 2016 – June 2021. Canada First Research April 2015 – June 2018. Developmental Origins Kislinger T (PI), Ailes L, Excellence Fund, Medicine of Health and Disease - Jumah NA (PI). MR-HIFU Bernardini MQ, Clarke B. A by Design, University of Implications for Men, Women, for Uterine Fibroids Clinical Novel Biomarker Discovery Toronto. $25,000. September Boys and Girls. Canadian Trial. PSI Foundation Graham Strategy Combining Primary 2016 – September 2019. Institutes of Health Research Farquharson Knowledge Tumour Xenograft Models (CIHR). $ 1,600,000.00 CAD. Li M (PI), MacKay H, Ferguson Translation Fellowship. and Glyco-Capture of June 2016 – June 2021. S, Haibe-Kains B, Rodin $450,000 CAD. January Secreted Proteins. Canadian G, Paige C. Cytokines and 2014 – December 2016. Kimmins S, Lambrot R, Institutes of Health Research Symptom Clusters in Ovarian Weiler H, Dott L, Librach (CIHR). $480,264 CAD. Keunun J (PI), Macgowan C. Cancer: A Machine Learning CL, Moskovtsev SI. Obesity April 2014 – March 2017. Preliminary Investigation of Approach to Identifying and Nutritional Programming the Utility of MRI for Measuring Kingdom JC (PI). Elucidating Intervention Targets. of the Paternal Sperm the Hematocrit in Fetal Herparin’s Role in Reducing Ontario Cancer Institute. Epigenome: Effects on Anemia. Physicians Services the Incidence and Effects of Collaborative Personalized Offspring Development and Incorporated Foundation. Preeclampsia & Offering a Cancer Medicine Team Grant. Health. Canadian Institutes New Investigator Application. Pathway to a Better Heparin $299,758 CAD. 2015–2017. of Health Research (CIHR) $115,221 CAD. September Product Used Specifically for Operating Grant. $1,077,100 Lee SK (PI). MiCare’s 2016 – August 2018. Preeclamptic Women. The CAD. August 2015 – July 2020. Clinician-Scientists Training Alva Foundation. Research Kewayosh A, Rabeneck L, Program. Ontario Ministry of Kimmins S (PI), Dodds L, Fund. $200,000 CAD. August Tinmouth J, Baxter NN, Health & Long-Term Care. Fishman JR, Lambrot R, 2015 – August 2018. Borkhoff CM, Deber RSB, $1,300,000. 2016–2017. Librach CL, Moskovtsev Dobrow M, Gesink D, Jackson Kingdom JC (PI), Cox B. SI, Weiler HA, Xia J. Obesity Lee SK (PI), Shah P (Co-PI), SF, Jumah NA, Llovet DN, Lofter Villious Trophoblast Turnover. and Nutritional Programming Jain (Co-PI). Toronto Perinatal AK, Marrett LD, Mackinnon Canadian Institutes of Health of the Paternal Sperm Brain Protection Research ML, Paszat LF. Improving Research (CIHR). Operating Epigenome: Effects on Collaboration. Canadian cancer screening among Grant. $719,235 CAD. March Offspring Development and Foundation for Innovation. First Nations and Métis. CIHR 2014 – February 2019. Health. Canadian Institutes $2,343,263. 2017–2021. Partnerships for Health System of Health Research (CIHR). Kingdom JC (PI), Cox B. Improvement, Grant. $562,491 Lipscombe LL (PI), Berger Nutrition, Metabolism and Placental Response to CAD. July 2013 – June 2018. H, Feig D, Fleming K, Grant Diabetes (Bridge Funding), Heparin: Implications for the S, Harvey P, Mukerji G, Price Khan S, Bitnun A, Kennedy VL, $1,047,500 CAD. October Prevention of Preeclampsia. J, Retnakaran R, Sherifali D, Loufty M, Read S, Underhill 2015 – September 2020. Canadian Institutes of Health Thorpe K. Avoiding Diabetes A, Yudin M. Developing Research (CIHR). Operating Kimmins S (PI), Librach CL, after Pregnancy Trial in Community Driven Consensus Grant. $521,660 CAD. October Moskovtsev SI, Weiler H, Moms (ADAPT-M). Canadian for Infant Feeding in HIV in 2012 – September 2016. Dodds L, Bale T, Fishman J, Institutes of Health Research Canada. Canadian Institutes Bailey J, Trasler J, MacFarlane Kupets R, Gien LT, Vicus D, (CIHR). $791,776 CAD. April of Health Research, Planning A, Didier R, Lambrot D, Jainguo Murphy KJ. Impact of the Pap: 2017 – March 2021. and Dissemination Grant. X, DeJager T, Aneck-Hahn N, History on Cervical Cancer $20,000 CAD. 2016. Lo KC, Librach CL, Bornman R, MacIntyre U, Peters in Women Aged 60 and Over.

72 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Peer-reviewed Grants

Moskovtsev SI, Gauthier- (CIHR) Foundation Grant. Impact of Wound Healing on Institutes of Health Research Fisher A. Academic Health Operating grant. $5,575,713 Ovarian Cancer Progression (CIHR). Operating grant. Changing the Paradigm for CAD. July 2015 – June 2022. and Sensitivity to Platinum- $388,000 CAD. March Male Fertility Treatment: based Agents: A Pilot Study 2017 – April 2021. Lye S (PI), Shynlova O, Standardized Automated Using a Syngeneic Orthotopic Adams K, Gravett M. Targeting Morshead C (PI), Nagy A, Platform for Sperm Retrieval. Mouse Model. Mount Sinai Leukocyte Activation to Shoichet M, Lipsman N. Cell Academic Health Science Hospital/University Health Prevent Preterm Labour. Transplantation for Stroke Centre’s Academic Funding Network Department of Burroughs Wellcome Fund Repair. Canada First Research Plan (AHSC AFP) Innovation Obstetrics and Gynecology Preterm Birth Initiative, Excellence Fund, Medicine by Fund. $333,436 CAD. March Research Fund Grant. $10,000. Operating grant. $600,000 Design, University of Toronto. 2015 – February 2017. July 2016 – June 2017. USD. July 2014 – June 2018. $54,000 CAD. September Loutfy M (PI), Yudin M, et McDonald S (PI), Giglia L, 2016 – September 2019. Lye S (PI), Shynlova O, al. Impactful Research with Thaban L, Maxwell C. A Mesiano S, Nadeem L. Murji A (Co-PI), Shirreff L (Co- Diverse Women Living with Clinical Care Pathway for Selective Progesterone PI), Brown A. Greater Toronto and at Risk of HIV in Canada. Obese Pregnant Women: A Receptor Modulators: Novel Area Surgical Gynaecology Canadian Institutes of Health Pilot Cluster Randomized Therapeutics for Preterm Birth Quality Scorecard. Mount Sinai Research, Foundation Grant. Control Trial in Obstetrics Prevention. March of Dimes Hospital, University Health $3,780,858 CAD. 2017–2024. Midwifery and Family Birth Defects Foundation, Network Academic Medical Medicine Clinics. Hamilton Lye S (PO), Adams Waldorf Operating grant. $225,000 Organization. $177,867 CAD. Academic Health Sciences K, Bocking A, Connor K, USD. May 2017 – April 2020. April 2017 – March 2019. Organization. $188,631 CAD. DeSantis T, Dong X, Dunk C, Macgowan C (PI), Kingdom April 2015 – March 2017. Murji A (PI), Kives S, Leyland Gingras A, Gravett M, Hood JC, Seed M, Sled J. Dynamic N, Singh S, Laberge P, Jackson L, Keating S, Kibschull M, McLaurin J (PI), Stefanovic 3D MRI of the Fetus: A New R, Vilos G, Polsky J, Fortin Kingdom JC, Mesiano S, B, Librach CL. Combination Method for Detecting Abnormal C, Bedaiwy, Sanders B, Nadeem L, Price N, Sadovsky Y, Therapy for Vascular Blood Flow and Oxygenation Belland L, Uretsky A, Theil J. Scherer S, Shynlova O, Zhang Regeneration in a Model of During Pregnancy. Canadian Multicentre Prospective Non- J. Pregnancy Complications Sporadic AD. The Weston Brain Institutes of Health Research interventional Study Assessing and Development Health: Institute, Grant. $15,000 CAD. (CIHR). Program Grant. the Management of Canadian Mechanisms, Diagnostics, December 2015 – July 2017. 363519. $542,795 CAD. March Women with Uterine Fibroids, A and Therapeutics. Canadian 2016 – February 2021. Miller S (PI), Seed M, Blaser Patient Registry. Allergan Inc. Institutes of Health S, Brant R, Chau V, Hickey E, $30,000 CAD. 2015–2018. Research (CIHR). Foundation Maheu C (PI), Lebel S (PI), Kingdom JC, Ly L, Macgowan Scheme - Live Pilot. Courbasson C, Singh M, Murphy KE (PI), Raboud J, C, Schwartz S, Sled J. $5,575,713 CAD. September Catton P, Bernstein L, Benea A, Serghides L, Silverman M, Cardiovascular Physiology 2014 – August 2021. Jolicoeur L, Lefebvre M, Harris Yudin M, Loufty M, Walmsley and Brain Development in C, Agnihotram R, Sidanie S, S, Papp E. The ProSPAR Study: Lye S, Shynlova O, Bocking Newborns with Congenital Ferguson S, Muraca L. Efficacy Progesterone Supplementation A. Prevention of Preterm Heart Disease. Canadian of a Cognitive-existential for HIV Positive Pregnant Birth: Targeting Inflammatory Institute of Health Research Intervention to Address Fear Women on Antiretrovirals. Pathways. March of Dimes. (CIHR). Operating Grant, of Recurrence in Women Canadian Foundation for $300,000 USD. 2014–2017. 341324. $1,008,289 CAD. with Cancer: A Randomized AIDS Research. $80,000 March 2015 – February 2021. Lye S (PI), Shynlova O, et Controlled Clinical Trial. CAD. July 2014 – June 2017. al. Pregnancy Complication Canadian Cancer Society Mitchell J (PI), Shynlova O, Murray-Davis B (Co-PI), and Developmental Health: Research Institute (CCSRI). Wilson M. Discovering the Melamed N (Co-PI), Berger Mechanisms, Diagnostics $300,000 CAD. February Transcription Regulatory H, Barrett J, Geary M, and Therapeutics. Canadian 2014 – February 2017. Networks that Control Uterine Ray J, McDonald S. Non- Institutes of Health Research Contractions. Canadian May T (PI), Lee A, Brown T. communicable Diseases

ANNUAL REPORT 2016/17 73

in Obstetrics: Improving Blindness (FFB). $225,000. EK, Naugler C, Park AL, Urquia Postovit L, May M, Zandstra Quality of Care and Maternal July 2015 – July 2018. ML, Van Wagner V. Using Novel P, Zhou Q, Pei X. Ontario Infant Outcomes through an Population-based Datasets Initiative in Personalized Nagy A (PI), Tremblay J, Obstetrical Research Network. to Produce and Implement Stem Cell Medicine. Canada Ellis J. Directing Cellular Canadian Institutes of Health Clinical Prediction Models Foundation for Innovation, Identity to Move Towards Research (CIHR). $1,500,000 for Preterm Preeclampsia, Infrastructure Operating Progenitor Cell Therapies. CAD. April 2016 – March 2021. Stillbirth, Maternal ICU, and Fund (IOF). $562,072. April Canada-Japan, Canadian Long-term Cardiovascular 2010 – March 2018. Nagy A (PI), Rogers I (Co-PI). Epigenetics, Environment and Disease among Canadian Improving the Safety, Efficacy, Health Research Consortium Roth D (PI), Zoltkin S, Morris Women. Canadian Institutes and Economics of Future (CEEHRC) Teams in Epigenetics S, Weksburg R, Willian A, of Health Research (CIHR). Stem Cell Therapies. Ministry of Stem Cells. $862,933. Adeli K, Murphy KE, Shah P, Project Grant. $336,380 CAD. of Research Innovation, April 2013 – March 2018. Gergolas E, Al Mahmud A, Islam March 2016 – February 2020. Ontario Research Fund. M, Shah E, Baqui A. Prenatal Nagy A (PI). Stem Cells $4,000,000 CAN. October Ray J (Co-PI), Geary M vitamin D trial in Bangladesh. and Regeneration Tier 1. 2016 – September 2021. (Co-PI), Berger H. Optimizing The Bill and Melinda Gates Government of Canada, Canada the Use of ASA Prophylaxis Foundation. $1,999,993. Nagy A (PI), Keating A, Research Chairs Program among Ontarian Women at July 2012 – June 2017. Kapoor M. Combining Gene (CRCP). $1,400,000. October High Risk for Preeclampsia. and Mesenchymal Stromal 2014 – September 2021. Sander B (PI), Espinel E, Academic Funding Program Cell Therapies: Steps Toward Gonzalez C, Kulkarni Manisha Nagy A (PI), Harding J. Local Innovation Funds. $17,968.75 Curing Arthritis. Stem Cell A, Miretti M, Wu J, Cevallos V, ON/OFF Control of Tolerance CAD. April 2016 – April 2017. Network Disease Team Ferraras J, Gubbay J, Jaenisch Toward Allograft Cell Grant. $394,623. December Ren Ke L (PI), Librach CL. Pre- T, Jimenez C, Khan K, Loeb M, Transplants. Ontario Institute 2016 – December 2017. clinical Development of a Novel Massad E, Morris S, Murphy of Medicine – Medicine by Umbilical Cord Perivascular KE, Ogden N, Rowland M, Wong Nagy A (PI), Waddell T, Post Design, Postdoctoral Fellowship Cell-based Therapy to Prevent W. Assessing ZIKV Transmission M. Introducing Fail-safe Award. $172,275 CAD. April Heart Failure. Ministry of Dynamics and Mitigation Pluripotent Cells into 2016 – March 2019. Research Innovation. Ontario Strategies: A Multidisciplinary Clinically Relevant Cell Nguyen G (PI), Huang V, Research Fund Excellence. Approach. Canadian Institutes Therapy Applications. Canada Maxwell C, Seow C, Vallis M. Grant. $4,231,731. February of Health Research (CIHR). First Research Excellence Coach-IBD Clinical Research 2015 – January 2018. $499,866 CAD. September Fund, Medicine by Design, Study. Crohns and Colitis 2016 – August 2019. University of Toronto. Rogers I (PI). Production of Foundation Canada. $375,000 $539,475 CAD. September Clinical Grade iPS Cells from Seed M (PI), Kingdom JC, CAD. April 2017 – April 2020. 2016 – September 2019. Umbilical Cord Blood and Widjaja E, Keating S, Kelly E, Plante M (PI), Ferguson S, Tissue. Ontario Centres of Keunen J, Manlhiot C, Miller S. Nagy A (PI). Somatic Kwon J, Brotto L, Fyles T, Excellence. $300,000 CAD. Brain Development Following Cell Reprogramming and Meyer R, Craighead P, Gavin May 2016 – April 2018. Late Onset Intrauterine Therapeutics. Canadian S, Arseneau J, Atri M. Cx.5 Growth Restriction. Canadian Institute of Health Research, Rogers I (PI). Improving Shape: The SHAPE Trial: Simple Institutes of Health Research Foundation Scheme Grant. efficacy and economics of Hysterectomy and Pelvic Node (CIHR). Project Grant, 364886. $2,616,629 CAD. July kidney disease therapies using Dissection in Early Cervix $550,440 CAD. March 2015 – June 2021. iPS cells. Stem Cell Network. Cancer. Canadian Institutes 2016 – February 2019. $90,811 CAD. September Nagy A (PI), Hacibekiroglu of Health Research (CIHR). 2016 – December 2017. Seed M (PI), Miller S (Co-PI), S. Combined Cell and $2,200,000 CAD. 2012–2020. Honsberger L, Kingdom Gene Therapy Towards the Rossant J (PI), Nagy A, Ray JG (PI), Berger H, Blake JC, McGowan C. Maternal Treatment of Age-Related Keating A, Stanford B, Wang JM, Geary M, Kingdom JC, Hyperoxygenation in Congenital Macular Degeneration. C, Zhao C, van der Kooy Maguire JL, Meloche J, Morgen Heart Disease. Thrasher The Foundation Fighting D, Keller G, Deng H, Li L,

74 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Peer-reviewed Grants

Research Fund. $248,613 AIDS Research. $181,808.88 Shore E (PI), Yousuf A, C, Serghides L, Keating S, USD. May 2016 – April 2019. CAD. 2016–2020. Satkunaratnuam A, Frecker Murphy KE. Environmental H. Design and Validation of Factors in Placental Pathology: Serghides L, Berger H, Serghides L (PI), Shynlova O, a Retroperitoneal Dissection A New Diagnostic Method Dunk C, Sled J, Yudin M.HIV Kibschull M. HIV Antiretrovirals Model. St. Michael’s Hospital Based on Umbilical Vessel Antiretroviral Exposure in and their Impact on Sex AFP. Innovation Grant. $10,521 Wave Mechanics. National Early Pregnancy – Assessing Steroids during Pregnancy: A CAD. January 2016 – June 2017. Institutes of Health (NIH) (USA). the Impact on Progesterone Potential Mechanism for the Research Project Cooperative Mediated Decidual Increased Adverse Pregnancy Shynlova O (PI), Lye S, Whittle Agreement. 1U10HD087177-01. Development and Function. Outcomes in Women with HIV. W, Sled J. MRI of Cervical $2,507,213 USD. September Canadian Institutes of Health Canadian Institutes of Health Morphology and Maternal 2015 – August 2018. Research, Foundation Grant. Research (CIHR). Operating Serum Blood Markers Predict $676,584 CAD. 2016–2021. grant. $596,127 CAD. Spontaneous Human Preterm Sled J (PI), Macgowan C, September 2013 – May 2018. Birth. Canadian Institutes Kingdom JC, Adamson SL, Serghides L (PI), Dunk C, Sled of Health Research (CIHR) Seed M, Jaeggi E, Jurisicova A. J, Yudin M, Berger H. The Shore E (PI), Yeung G, Catalyst Grant: Catalyzing Advanced MRI Methods for Early ProSPAR Study: Progesterone Grantcharov T. Minimizing Innovation in Preterm Birth Detection and Characterization Supplementation for HIV Perioperative Delays, Research, Operating Grant. of Placental Dysfunction and Positive Pregnant Women on Maximizing Operating Room $200,000 CAD. November the Monitoring of Therapy. Anti-Retrovirals. Canadian Efficiency. St. Michael’s 2016 – October 2018. Canadian Institutes of Health Institutes of Health Research, Hospital AFP. Innovation Research (CIHR). Operating Canadian HIV Trails Network, Grant. $59,468 CAD. January Sled J (PI), Baschat A, Grant. $470,585 CAD. October Canadian Foundation for 2017 – June 2018. Kingdom JC, MacGowan

ANNUAL REPORT 2016/17 75 2013 – September 2016. G. Transcranial Direct Current Stimulation for Depression in Sled J (PI), Macgowan C, Pregnancy: A Pilot Randomized Kingdom JC. Ultrasound Controlled Trial. Catalyst Grant, Detection of Placental CIHR Insitute of Child and Pathology Based on Youth Health, Hospital for Sick Hemodynamics Pulse Children Foudnation. $113,725 Wave Reflection. Canadian CAD. July 2015 – June 2016. Institutes of Health Research (CIHR). $799,425 CAD. April Von Dadelszen P (Co-PI), Lim 2017 – March 2022. K (Co-PI), Lalji S, Ansermino JM, Audibert F, Bujold E, Sled J (PI), Stefanovic B Chanoine JP, Davidge ST, (Co-PI), Baker A, Macgowan Gruslin AM, Magee L, Piedboeuf C, McLaurin J. Imaging of B, Robinson WP, Seward Cerebral Vascular Adaptation G, Singer J, Synees AR. The Following Traumatic Brain Canadian STRIDER Trial: Injury. Canadian Institutes Sildenafil for Dismal Prognosis of Health Research, Project IUGR, A Randomized Controlled Grant. $910,350 CAD. April Trial of Sildenafil Therapy for 2017 – March 2022. Dismas Prognosis Early-onset Thistle PJ (PI), Schnipper Intrauterine Growth Restriction. LE, Fitzpatrick M, Chirenje CIHR, Canadian Institute for ZM. Prevalence and Subtype Health Research. $630,246 Distribution of Cervical High- CAD. July 2015 – June 2016. risk Human Papillomavirus Zheng G (PI), Valic M, Zhang Among Women Presenting for C, Jiang W, Ding L, Chen J, Cervical Cancer Screening Bernardini MQ. Targeting at Karanda Mission Hospital Ovarian Cancer with Screening for Cervical Cancer, Porphysome Nanotechnology. Karanda Mission Hospital, U.S. Department of Defense. Mt. Darwin, Zimbabwe. Sarita $470,000 USD. September Kenedy East Foundation 2013 – September 2016. $60,000 US. 2017–2020. Zúñiga-Pflücker JC (PI), Vachon-Marceau C (PI), Okun Nagy A, Nostro C, Brooks N (Co-PI). The Role of First D, van der Kooy D, Hirano Trimester Placental Thickness N, McGaha T. Induction and on the Risk of Preeclampsia Maintenance of Allograft and Other Placentally Tolerance in the Absence of Mediated Adverse Pregnancy Systemic Immunosuppression. Outcomes. Department of Canada First Research Obstetrics & Gynaecology, Excellence Fund, Medicine by Mount Sinai Hospital, Design, University of Toronto. Research Fund. $10,000 $270,000 CAD. September CAD. July 2016 – June 2017. 2016 – September 2019. Vigod S, Blumberger D, Murphy KE, Dennis CL, Daskalakis ZG, Ray JG, Oberlander A, Seaward

76 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Peer-Reviewed Publications

ANNUAL REPORT 2016/17 77 ORIGINAL RESEARCH

Aavoid ABR, Ryan H, Magee LA, von and Exosome Biology, Xenobiotics and Pathology Review in Vulvar Cancer: Results Dadelszen P, Fjeli C, Walley KR and the Endocrine Disruptors and Pregnancy and From a Population-based Cohort Study. Int Ciper Study Site Coordinators (Seaward Lipid and Placental Function. Placenta. J Gynecol Pathol. 2017 Mar;36(2):107-110. G). Multiple Organ Dysfunction Score 2016 Dec; 48 Suppl 1: S12-S16. Barrett JFR, Zaltz A, Geary M, Sermer is Superior to the Obstetric-Specific Aldina Z, Wormsbecker AE, Urquia M, Kingdom JC. Beward Selection Bias. Sepsis in Obstetrics Score in Predicting M, MacGillivray J, Taerk E, Yudin MH, CMAJ. 2017 Aug 28;189(34):e1096. Mortality in Septic Obstetric Patients. Campbell DM. HIV Prophylaxis in High Crit Care Med. 2017 Jan: 45(1) e49-57. Berger H, Gagnon R, Sermer M, Basso Risk Newborns: An Examination of M, Bos H, Brown RN, Bujold E, Cooper Abdulwahab S, Ng AHC, Chamberlain Sociodemographic Factors in an Inner SL, Gagnon R, Gouin K, McLeod NL, MD, Ahmado H, Behan L-A, Gomaa H, City Context. Can J Infect Dis Med Menticoglou SM, Mundle WR, Roggensack Casper RF, Wheeler AR. Towards a Microbiol 2016 April:2782786. A, Sanderson FL, Walsh JD. Le Diabète Personalized Approach to Aromatase Al-Refai Alyaa, Ryan G, Van Mieghem T. Pendant la Grossesse. J Obstet Gynaecol Inhibitor Therapy: A Digital Microfluidic Maternal Risks of Fetal Therapy. Curr Opin Can. 2016 Jul;38(7):680-694.e2. Platform for Rapid Analysis of Estradiol Obstet Gynecol. 2017 April;29(2):80-84. in Core-needle-biopsies. Lab Chip. Berger H, Gagnon R, Sermer M, Basso 2017 May 2;17(9):1594-1602. Arya S, Ye C, Connelly PW, Hanley AJ, M, Bos H, Brown RN, Bujold E, Cooper Sermer M, Zinman B, Retnakaran R. SL, Gagnon R, Gouin K, McLeod NL, Adams J, Liu Z, Ren YA, Wun WS, Zhou Asymmetric Dimethylarginine and Arginine Menticoglou SM, Mundle WR, Roggensack W, Kenigsberg S, Librach CL, Valdes Metabolites in Women with and without a A, Sanderson FL, Walsh JD. Diabetes C, Gibbons W, Richards J. Enhanced History of Gestational Diabetes. J Diabetes in Pregnancy. J Obstet Gynaecol Inflammatory Transcriptome in the Complications. 2017 Jun;31(6):964-970. Can. 2016 Jul;38(7):667-679.e1. Granulosa Cells of Women with Polycystic Ovarian Syndrome. J Clin Endocrinol Baczyk D, Audette MC, Drewlo S, Levytska Bertin E, Piccoli M, Franzin C, Nagy A, Metab. 2016 Sep;101(9):3459-68. K, Kingdom JC. SUMO-4: A Novel Mileikovsky M, De Coppi P, Pozzobon Functional Candidate in the Placental M. The Production of Pluripotent Ahmed RJ, Gafni A, Hutton EK, Hu ZJ, Protein SUMOylation Machinery. PLoS Stem Cells from Mouse Amniotic Fluid Pullenayegum E, von Dadelszen P, Rey One. 2017 May 17;12(5):e0178056. Cells Using a Transposon System. E, Ross S, Asztalos E, Murphy KE, J Vis Exp. 2017 Feb 28;(120). Menzies J, Sanchez JJ, Ganzevoort W, Bailey LJ, Alahari S, Tagliaferro A, Post Helewa M, Lee SK, Lee T, Logan AG, M, Caniggia I. Augmented Trophoblast Bhagra CJ, D’Souza R, Silversides CK. Moutquin JM, Singer J, Thornton JG, Welch Cell Death in Preeclampsia can Proceed Valvular Heart Disease and Pregnancy R, Magee LA. The Cost Implications via Ceramide-mediated Necroptosis. Part II: Management of Prosthetic of Less Tight Versus Tight Control of Cell Death Dis. 2017 Feb 2;8(2):e2590. Valves. Heart. 2017 Jan;103:244-252. Hypertension in Pregnancy (CHIPS Trial). Hypertension. 2016 Oct; 68(4):1049-55. Bajaj H, Ye C, Hanley AJ, Connelly PW, Bhattacharjee J, Alahari S, Sallais Sermer M, Zinman B, Retnakaran R. Prior J, Tagliaferro A, Post M, Caniggia I. Alayed N, Okun N, Chitayat D, Kolomietz Lactation Reduces Future Diabetic Risk Dynamic Regulation of HIF1A Stability E. EP09.06: Chromosomal Microarray through Sustained Postweaning Effects on by SUMO2/3 and SENP3 in the Human as a First Tier Test Following Diagnostic Insulin Sensitivity. Am J Physiol Endocrinol Placenta. Placenta. 2016 Apr;40:8-17. Prenatal Procedures: The Toronto Mount Metab. 2017 Mar 1;321(3):E215-E223. Sinai Hospital Experience. Ultrasound Bowlby DA, Brown TJ, Hochberg RB, Obstet Gynecol. 2016 Sep;48 Suppl 1:300. Balakier H, Sojeckie A, Motamedi G, Librach MacLusky NJ. In Vitro Autoradiographic CL. Impact of Multinucleated Blastomeres Analysis of Regional Changes in Albrecht C, Caniggia I, Clifton V, Göhner on Embryo Developmental Competence, Estrogen Receptor Alpha in the C, Harris L, Hemmings D, Jawerbaum A, Morphokinetics, and Aneuploidy. Fertil Brains of Cycling Female Rats. Johnstone E, Jones H, Keelan J, Lewis R, Steril. 2016 Sep 1;106(3):608-614.e2. Neuroendocrinology. 2016;103(5):538-51. Mitchell M, Murthi P, Powell T, Saffery R, Smith R, Vaillancourt C, Wadsack C, Barbera L, Gien LT, Sutradhar R, Thomas Bouchard-Fortier G, Kim RH, Allen L, Salomon C. IFPA meeting 2015 workshop G, Covens A, Elit L, Fyles A, Rakovitch Gupta A, May T. Fertility-sparing Surgery report IV: Nanomedicine Applications E, Liu Y, Khalifa M. The Added Value of for the Management of Young Women

78 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY ORIGINAL RESEARCH

with Embryonal Rhabdomyosarcoma Chi L, Ahmed A, Roy AR, Vuong S, Cahill associated T Cells. Nat Med. 2017 Feb 6. of the Cervix: A Case Series. Gynecol LS, Caporiccio L, Sled JG, Caniggia I, Crosby DA, Sarangapani A, Simpson A, Oncol Rep. 2016 Aug 26;18:4-7. Wilson MD, Delgado-Olguin P.G9a Controls Windrim R, Satkunaratnam A, Higgins Placental Vascular Maturation by Activating Bouchard-Fortier, G, Panzarella T, Rosen MF. An International Assessment of Trainee the Notch Pathway. Development. B, et al. Endometrioid Carcinoma of the Experience, Confidence, and Comfort 2017 Jun 1;144(11):1976-1987. Ovary: Outcomes Compared to Serous in Operative Vaginal Delivery. Ir J Med Carcinoma after 10 Years of Follow-up. J Christakis MK, Shore EM, Pulver Sci. 2017 Mar 7. [Epub ahead of print] Obstet Gynaecol Can. 2017 Jan;39(1):34-41. A, McDermott CD. Female Pelvic De Souza LR, Berger H, Retnakaran R, Medicine and Reconstructive Surgery Brar H, Hogen L, Covens A. Cost- Vlachou PA, Maguire JL, Nathens AB, in Canada: A Survey of Obstetrician- effectiveness of Sentinel Node Biopsy Connelly PW, Ray JG. Hepatic Fat and Gynecologists and Urologists. Female and Pathological Ultrastaging in Patients Abdominal Adiposity in Early Pregnancy Pelvic Medicine and Reconstr Surg. with Early Stage Cervical Cancer. Cancer. Together Predict Impaired Glucose 2017 May/June;23(3):195-203. 2017 May 15;123(10):1751-1759. Homeostasis in Mid-pregnancy. Nutr Chuang L, Randall T, Denny L, Johnston C, Diabetes. 2016 Sep 19;6(9):e229. Brar H, May T, Tau N, Langer D, MacCrostie Schmeler K, Covens A, Cibula D, Bookman P, Han K, Metser U. Detection of De Souza LR, Retnakaran R, Berger M, Rawal S, DePetrillo D, Nam J, Goodman Extra-regional Tumour Recurrence with H, Nathens AB, Maguire JL, Connelly A, Naik R, Manchanda R, Gaffney D, Small W 18F-FDG-PET/CT in Patients with Recurrent PW, Park AL, Ray JG. First-trimester Jr, Creutzberg C, Rattray C, Kesic V, Paraja Gynaecological Malignancies Being Maternal Abdominal Adiposity and R, Eiken M, Belleson K, Coleman R, Barakat Considered for Radical Salvage Surgery. Adiponectin in Pregnancy. Diabet R, Trimble E, Quinn M. Sister Society Clin Radiol. 2017 Apr;72(4):302-306. Med. 2017 Jan;34(1):135-137. Meeting on Global Education Development Casper RF. Is Gonadotropin Ovarian and Collaboration: Meeting Report. Int J Deter RL, Lee W, Kingdom JC, Romero R. Stimulation for Unexplained Infertility Gynecol Cancer. 2016 Jul;26(6):1186-8. Fetal Growth Pathology Score: A Novel Any Longer Warranted? Fetil Steril. Ultrasound Parameter for Individualized Cohen SL, Senapati S, Gargiulo AR, 2016 Sept:106(3):528-529. Assessment of Third Trimester Srouji SS, Tu F, Solnik MJ, et al. Dilute Growth Abnormalities. J Matern Fetal Casper RF. Introduction: A Focus on the versus Concentrated Vasopressin Neonatal Med. 2017 Mar 20:1-11. Medical Management of Endometriosis. Administration during Laparoscopic Fertil Steril. 2017 Mar:107(3):521-522. Myomectomy: A Randomized Controlled Deter RL, Levytska K, Lee W, Melamed Trial. BJOG. 2017 Jan;124(2):262-268. N, Kingdom JC. Classifying Neonatal Casper RF. Progestin-only Pills May Growth Outcomes: Use of Birth Weight, be a Better First-line Treatment for Comeau I, Hubner N, Kives S, Allen L. Rates Placental Evaluation, and Individualized Endometriosis than Combined Estrogen- and Techniques for Oophoropexy in Pediatric Growth Assessment. J Matern Fetal progestin Contraceptive Pills. Fetil Ovarian Torsion: A Single Institution Case Neonatal Med. 2016 Dec;29(24):3939-49. Steril. 2017 Mar:107(3):533-536. Series. Journal of Pediatric & Adolescent Gynecology. 2017 Jun;30(3):418-421 Diou K, Walmsley SL, Murphy KE, Raboud Chandrasekaran N, Yudin MH, Berger J, Loutfy M, Yudin MH, Silverman M, H. Uterine Diverticulum with Fetal Leg Covens A, Kohler C, Nam JH, Naumann Ladhani NN, Serghides L. Progesterone Entrapment: A Case Report. J Obstet Rw, Obermair A, Querleu D. Cost Supplementation for HIV-positive Gynaecol Can. 2017 Oct;39(10):894-896. Efficiency of Robotic Surgery. Int J Pregnant Women on Protease Inhibitor- Gynecol Cancer 2016:26:1186-1188. Chaikof M, Gat I, Lazer T, Quach based Antiretroviral Regimens (the K, Al Kudmani B, Zohni K, Glass K, Crome SQ, Nguyen LT, Lopez-Verges S, ProSPAR Study): A Study Protocol for Sharma P, Baratz A, Librach CL. Yang SY, Martin B, Yam JY, Johnson DJ, a Pilot Randomized Controlled Trial. Lower Complication Rates with Office Nie J, Pniak M, Yen PH, Milea A, Sowamber Pilot and Feasibility Studies 2;49:2016. Based D and C Under Ultrasound R, Katz SR, Bernardini MQ, Clarke BA, doi 10.1186/s40814-016-0087-6. Guidance for Missed Abortions. Minerva Shaw PA, Lang PA, Berman HK, Pugh TJ, Dodd JM, Anderson C, Dickinson JE, Ginecologica. 2017 Feb;69(1):23-28. Lanier LL, Ohashi PS. A Distinct Innate Louise J, Deussen A, Grivell Rm, Voto L, Lymphoid Cell Population Regulates Tumor-

ANNUAL REPORT 2016/17 79

Kilby MD, Windrim R, Ryan G. Voto G, Systematic Review and Meta-analysis. Eur Metformin in Women with Type 2 Diabetes Saa G, Gardener G, Thomas J, Muller P, Heart J. 2017 May 14;38(19):1509-1516. in Pregnancy (MiTy): A Multi-Center Wilkinson C, Crowther CA, Kannieappan L, Randomized Controlled Trial. BMC Ermini L, Morganti E, Post A, Yeganeh B, Devlieger R, Gertis A, Richter J, Galjaard Pregnancy Childbirth. 2016 Jul;16(1):173. Caniggia I, Leadley M, Faria CC, Rutka S, Audibert F, Seaward G, Anastiadis C, JT, Post M. Imaging Mass Spectrometry Gaffney D, Small B, Kitchener H, Young Skoll A, Fernandez A, Cheema D, McParland Identifies Prognostic Ganglioside Species R, Viswanathan A, Trimble T, Covens A, P, Moore R, Sreenan C, Parry E, Hauch in Rodent Intracranial Transplants of Wilailak S, Lertkhachonsuk AA, Sitathanee H, Tuohy J, Kell C, Pretlove S, Cameron Glioma and Medulloblastoma. PLoS C, Mahantshetty U, Fisher B, Springer A, Wu P, Court S. Fetal MCA Doppler to One. 2017 May 2;12(5):e0176254. S, Pollatz T, Spiller A, Bacon M, Jhingran Time Intrauterine Transfusions in Red Cell A. Cervix Cancer Research Network Alloimmunization: A Randomized Trial. Ermini L, Post M, Caniggia I. (CCRN): Improving Access to Cervix Ultrasound Obstet Gyncol. 2017 Jul 12. doi: Statins, Mevalonate Pathway and its Cancer Trials on a Global Scale. Int J 10.1002/uog.18807. [Epub ahead of print] Intermediate Products in Placental Gynecol Cancer 26:1690-1693, 2016. Development and Preeclampsia. Curr Duan AQ, Keunen J, Portnoy S, Zhu MY, Mol Pharmacol. 2017;10(2):152-160. Gagnon LH, MacGillivray J, Urquia ML, Anastasiadis C, Ryan G, Porayette P, Caprara D, Murphy KE, Yudin MH. Saini B, Sled J, Macgowan C, Seed M. Esfandiari N, Bunnell ME, Casper RF. Antiretroviral Therapy During Pregnancy Preliminary Investigation of the Utility Human Embryo Mosaicism: Did we Drop and Risk of Preterm Birth. Eur J Ob of MRI for Measuring the Hematocrit the Ball on Chromosomal Testing? J Assist Gyn Repro Biol 201;51-5:2016. in Fetal Anemia. Ultrasound Obstet Reprod Genet. 2016 Nov: 33(11):1439-1444. Gynecol. 2016 Sep;48 Suppl 1:237. Gat I, Mejia SB, Balakier H, Librach CL. Faiz M, Nagy A, Morshead CM. Response The Use of Coenzyme Q10 and DHEA Dunn WB, Allwood JW, Van Mieghem T, to: Where do you come from and What are During IUI and IVF Cycles in Patients with Morris RK, Fox CE, Kilby M. Carbohydrate you Going to Become, Reactive Astrocyte? Decreased Ovarian Reserve. Gynecological and Fatty Acid Perturbations in the Stem Cell Investig. 2016 Jul22;3:32. Endocrinology. 2016 Jul;32(7):534-7. Amniotic Fluid of the Recipient Twin of Farine D. Intrapartum Care (editorial). J Pregnancies Complicated by Twin-twin Gat I, Tang K, Quach K, Kuznyotsov V, Perinat Medicine. 2017 Apr.1;45(3):269-271. Transfusion Syndrome in Relation to Antes R, Zohni K, Felice M, Librach Treatment and Fetal Cardiovascular Farine T, Lye S, Shynlova O. CL. Sperm DNA Fragmentation Index Risk. Placenta. 2016 Aug;44:6-12. Peripheral Maternal Leukocytes are does not Correlate with Blastocyst Activated in Response to Factors Aneuploidy or Morphological Grading. D’Souza R, Kingdom JC. Preeclampsia. PLoS One: 2017 Jun 7;12(6):e0179002. CMAJ. 2016 Nov 1;188(16):1178. Secreted by Pregnant Human Uterine Tissues. Cel Mol Immunology. 2017 Gat I, Maghen L, Felice M, Wyse B, Zohni K, D’Souza R, Sermer M, Silversides May [Epub ahead of print] Jarvi K, Lo K, Gauthier-Fisher A, Librach C. The Management of the Cardiac CL. Optimal Culture Conditions are Critical Patient in Labour: Primum Non Feig DS, Asztalos E, Corcoy R, De Leiva A, for Efficient Expansion of Human Testicular Nocere. BJOG. 2017 Aug;124(9):1310. Donovan L, Hod M, Jovanovic L, Keely E, Somatic and Germ Cells In Vitro. Fertility doi: 10.1111/1471-0528.14632 Kollman C, McManus R, Murphy KE, Ruedy K, Sanchez JJ, Tomlinson G, Murphy HR; and Sterility. 2017 Mar;107(3):595-605.e7 D’Souza R, Silversides K, Mclintock CONCEPTT Collaborative Group. CONCEPTT: Gemmell L, Martin L, Murphy KE, Modi N, C. Choosing the Optimal Method of Continuous Glucose Monitoring in Women Håkansson S, Reichman B, Lui K, Kusuda Anticoagulation for Pregnant Women with Type 1 Diabetes in Pregnancy Trial: A S, Sjörs G, Mirea L, Darlow BA, Mori R, with Mechanical Heart Valves. Seminars Multi-center, Multi-national, Randomized Lee SK, Shah PS. Hypertensive Disorders in Thrombosis and Hemostasis. Controlled Trial – Study Protocol. BMC of Pregnancy and Outcomes of Preterm 2016 Oct;42(7):798-804. Pregnancy Childbirth. 2016 Jul;16(1):167. Infants of 24 to 28 Weeks Gestation. J D’Souza R, Ostro J, Shah PS, Silversides Feig DS, Murphy KE, Asztalos E, Tomlinson Perinatol. 2016 Dec;36(12):1067-1072. CK, Malinowski A, Murphy KE, Sermer M, G, Sanchez J, Zinman B, Ohlsson A, Ryan Gien LT, Sutradhar R, Thomas G, Covens Shehata N. Anticoagulation for Pregnant EA, Fantus IG, Armson AB, Lipscombe A, Elit L, Fyles A, Rakovitch E, Khalifa MA, Women with Mechanical Heart Valves: A LL, Barrett JF; MiTy Collaborative Group.

80 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Original Research

Liu Y, Barbera L. Does a Groin Dissection Genet. 2016 Dec;33(12):1553-1557. M, Dougan S, Okun N. Enhanced First in Vulvar Cancer Affect Recurrence Trimester Screening for Trisomy 21 Hackmon R, Librach CL, Burwick R, and Overall Survival? Results from a with Contingent Cell-Free Fetal DNA: Rodrigues N, Farine D, Berger H. Population-based Cohort Study. Gynecol A Comparative Performance and Cost Do Early Fetal Measurements and Oncol. 2017 Feb;144(2):318-323. Analysis. J Obstet Gynaecol Can. 2017 Nuchal Translucency Correlate with Jun 14. pii: S1701-2163(16)39844-9. Glubb DM, Johnatty SE, Quinn MCJ, O’Mara Term Birth Weight? J Obstet Gynaecol TA, Tyrer JP, Gao B, Fasching PA, Beckmann Can. 2017 Sep;39(9):750-756. . Huang QT, Shynlova O, Kibschull M, Zhong MW, Lambrechts D, Vergote I, Velez M, Yu YH, Matthews S, Lye S. P-glycoprotein Hiersch L, Melamed N, Aviram A, Edwards DR, Beeghly-Fadiel A, Benitez J, Expression and Localization in the Rat Bardin R, Yogev Y, Ashwal E. Role of Garcia MJ, Goodman MT, Thompson PJ, Dörk Uterus Throughout Gestation and Labour. Cervical Length Measurement for T, Dürst M, Modungo F, Moysich K, Heitz F, Reproduction. 2016; 152(3): 195-204. Preterm Delivery Prediction in Women du Bois A, Pfisterer J, Hillemanns P, Karlan with Threatened Preterm Labor and Hubner N, Langer J, Kives S, Allen L. BY, Lester J, Goode EL, Cunningham JM, Cervical Dilatation. J Ultrasound Med. Evolution in the Management of Pediatric Winham SJ, Larson MC, McCauley BM, Kjær 2016 Dec;35(12):2631-2640. and Adolescent Ovarian Torsion as a SK, Jensen A, Schildkraut JM, Berchuck A, Result of Quality Improvement Measures. Cramer DW, Terry KL, Salvesen HB, Bjorge Hiersch L, Rosen H, Okby R, Freeman Journal of Pediatric & Adolescent L, Webb PM, Grant P, Pejovic T, Moffitt M, H, Barrett J, Melamed N. The Greater Gynecology. Feb 2017: 30(1) 132-137 Hogdall CK, Hogdall E, Paul J, Glasspool Risk of Preterm Birth in Triplets is R, Bernardini MQ, Tone A, Huntsman D, Mirrored by a More Rapid Cervical Hunter T, Shah J, Synnes A, Shivananda S, Woo M, Group A, deFazio A, Kennedy CJ, Shortening Along Gestation. Am J Ryan G, Shah PS, Murphy KE; on behalf of Pharoah PDP, MacGregor S, Chenevix- Obstet Gynecol. 2016 Sep;215(3):357. the Canadian Neonatal Network. Neonatal Trench G. Analyses of Germline Variants Outcomes of Preterm Twins According to Hiersch L, Shinar S, Melamed N, Aviram Associated with Ovarian Cancer Survival Mode of Birth and Presentation. J Matern A, Hadar E, Yogev Y, Ashwal E. Recurrent Identify Functional Candidates at the 1q22 Fetal Neonatal Med. 2017 Mar 8:1-7. and 19p12 Outcome Loci. Oncotarget. Placenta-Mediated Complications in 2017 Jun 15;8(39):64670-64684. Women with Three Consecutive Deliveries. Husslein H, Frecker H, Shore EM, Obstet Gynecol. 2017 Mar;129(3):416-421. Lefebvre GG, Latta E, Montanari E, Goldberg H, Allen L, Kives S. Satkunaratnam A. Comparing Two Hines D, Modi N, Lee SK, Isayama T, Sjörs Fetiform Teratoma in the Ovary of a Uterine Manipulators at Total Laparoscopic G, Gagliardi L, Lehtonen L, Vento M, 7-year-old: A Case Report. Journal of Hysterectomy. Journal of Minimally Kusuda S, Bassler D, Mori R, Reichman Pediatric and Adolescent Gynecology. Invasive Gynecology. 2017; 24(5):764-71. 2017 Apr 30(2):256-258. B, Håkansson S, Darlow BA, Adams M, Rusconi F, San Feliciano L, Lui K, Morisaki Iqbal F, Szaraz P, Librach Matthew, Gotz T, Jones C. Prioritization of Patients N, Musrap N, Shah PS, International Gauthier-Fisher A, Librach CL Angiogenic for Funded IVF in Ontario: A Survey of Network for Evaluating Outcomes (iNeo) Potency Evaluation of Cell Therapy Fertility Centres. J Obstet Gynaecol of Neonates. Scoping Review Shows Candidates by a Novel Application of Can. 2017 Mar;39(3):138-144. Wide Variation in the Definitions of the In Vitro Aortic Ring Assay. Stem Bronchopulmonary Dysplasia in Preterm Cell Res Ther. 2017 Aug 14;8(1):184. Gurau D, Zaltz A, Yoo WK, Rahmani Infants and Calls for a Consensus. MR. All Tied Up and Nowhere to Go: Iqbal F, Szaraz P, Librach M, Gauthier- Acta Paediatr. 2017;106.3:366-74. Report of a Figure-eight Umbilical Cord Fisher A, Li R, Librach CL. The Aortic Complex True Knot and Triple Nuchal Cord Hogen L, Thomas G, Bernardini MQ, Ring Co-culture Assay: A Convenient Detected on Antenatal Sonography. J Bassiouny D, Brar H, Gien L, Rosen B, Tool to Assess the Angiogenic Potential Ultrasound Med. 2016 Jun;35(6):1361-3. Le L, Vicus D. The Effect of Adjuvant of Mesenchymal Stromal Cells (MSCs) Radiation on Survival in Early Stage In Vitro. J Vis Exp. 2017 Sep 18;(127). Haas J, Meriano J, Laskin C, Benov Y, Clear Cell Ovarian Carcinoma. Gynecol Barzilay E, Casper RF, Cadesky K. Clinical Jang JY, Choi SY, Park I, Park DY, Choe Oncol. 2016 Nov;143(2):258-263. Pregnancy Rate Following Frozen Embryo K, Kim P, Kim YK, Lee BJ, Hirashima M, Transfer is Higher with Blastocysts Vitrified Huang T, Meschino WS, Teitelbaum Kubota Y, Park JW, Cheng SY, Nagy A, Park on Day 5 than on Day 6. J Assist Reprod

ANNUAL REPORT 2016/17 81

YJ, Alitalo K, Shong M, Koh GY. VEGRR2 Kibel M, Asztalos E, Barrett J, Dunn MS, W, Colantonio D, Read SE, Bitnun A. but not VEGFR3 Governs Integrity and Tward C, Pittini A, Melamed N. Outcomes Nevirapine Pharmacokinetics and Safety Remodeling of Thyroid Angiofollicular Unit of Pregnancies Complicated by Preterm in Neonates Receiving Combination in Normal State and During Goitrogenesis. Premature Rupture of Membranes Between Antiretroviral Therapy for Prevention EMBO Mol Med. 2017 Jun;9(6):750-769. 20 and 24 Weeks of Gestation. Obstet of Vertical HIV Transmission. J Acquir Gynecol. 2016 Aug;128(2):313-20. Immune Defic Syndr 74(5);493-8:2017. Joag VR, McKinnon LR, Liu J, Kidane ST, doi 10.1097/QAI.0000000000001291. Yudin MH, Nyanga B, Kimwaki S, Besel Kibel M, Barrett J, Tward C, Pittini A, Kahn KE, Obila JO, Huibner S, Oyugi JO, Arthos M, Melamed N. The Natural History of Leavey K, Benton SJ, Grynspan D, J, Anzala O, Kimani J, Ostrowski MA. Preterm Premature Rupture of Membranes Kingdom JC, Bainbridge SA, Cox BJ. Identification of Preferential CD4(+) T-cell in Twin Pregnancies. J Matern Fetal Unsupervised Placental Gene Expression Targets for HIV Infection in the Cervix. Neonatal Med. 2017 Aug;30(15):1829-1835. Profiling Identifies Clinically Relevant Mucosal Immunol Jan;9(1);1-12:2016. Subclasses of Human Preeclampsia. Kennedy VL, Collins M, Yudin MH, Serghides Hypertension. 2016 Jul;68(1):137-47. Jodar M, Sendler E, Moskovtsev SI, L, Walmsley S, Angel JB, Ongoiba F, Librach CL, Goodrich R, Swanson S, Hauser Powis J, Smaill F, Tharao W, Rachlis A, Lennox G, Covens A. Can Sentinel R, Diamond MP, Krawetz SA. Response Silverman M, Sandre R, Regier DA, Loutfy Lymph Node Biopsy Replace to Comment on Absence of Sperm RNA M. Exploring the Factors Considered by Pelvic Lymphadenectomy for Early Elements Correlates with Idiopathic People Living with HIV and their Partners Cervical Cancer? Gynecologic Male Infertility. Science translational During Preconception. J Int Assoc Provid Oncology 114:16-20, 2016. medicine. 2016, Aug 24;8(353):353tr1. AIDS Care May/June 16(3);239-46:2017. LePage K, Selk A. What Do Patients Jumah NA, Edwards C, Loewen L, Dooley Kfouri J, D’Souza R. Antenatal Want? A Needs Assessment of Vulvodynia J, Gerber-Finn L, L Kelly L. Observational Corticosteroids. CMAJ. 2017 Patients Attending a Vulvar Diseases Study of the Safety of Buprenorphine Feb 27;189(8):E319. Clinic. Sexual Medicine. 2016 July and Naloxone in Pregnancy in a Rural 30. Pii: S2050-1161(16)30046-0. Koscik RJE, Reid G, Kim SO, Li W, Challis and Remote Population. BMJ Open. JRG, Bocking AD. Effect of Lactobacillus Leung F, Bernardini MQ, Brown MD, Zheng 2016 Oct 31;6(10):e011774. Rhamnosus GR-1 Supernatant on Cytokine Y, Molina R, Bast RC Jr, Davis G, Serra S, Kan N, Silverman E, Kingdom JC, Dutil N, and Chemokine Output from Human Diamandis EP, Kulasingam V. Validation of Laskin C, Jaeggi E. Serial Echocardiology Amnion Cells Treated with Lipteichoic a Novel Biomarker Panel for the Detection for Immune-mediated Heart Disease Acid and Lipopolysaccharide. Reprod of Ovarian Cancer. Cancer Epidemiol in the Fetus: Results of a Risk-based Sci. 2017 Jan 1:1933719117711259. Biomarkers Prev. 2016 Sep;25(9):1333-40. Prospective Surveillance Strategy. Kufaishi H, Alarab M, Drutz H, Levytska K, Higgins M, Keating S, Prenat Diagn. 2017 Apr;37(4):375-382. Lye S. Shynlova O. Comparative Melamed N, Walker M, Sebire NJ, Kingdom Keir M, Bhagra C, Vatenmakher D, Characterization of Vaginal Cells Derived JC. Placental Pathology in Relation Arancibia-Galilea F, Jansen K, Toh N, from Premenopausal Women with and to Uterine Artery Doppler Findings in Silversides CK, Colman J, Siu SC, Sermer without Severe Pelvic Organ Prolapse. Pregnancies with Severe Intrauterine M, Crean AM, Wald RM. Paediatric-onset Reprod Sci. 2016 Jul;23(7):931-43. Growth Restriction and Abnormal Coronary Artery Anomalies in Pregnancy: A Umbilical Artery Doppler Changes. Am Kufaishi H, Alarab M, Drutz H, Lye S, Single-centre Experience and Systematic J Perinatol. 2017 Apr;34(5):451-457. Shynlova O. Static Mechanical Loading Literature Review Cardiol Young. 2017 Apr Influences the Expression of Extracellular Linder N, Hiersch L, Fridman E, Klinger G, 17:1-9. Doi: 10.1017/S1047951117000658 Matrix and Cell Adhesion Proteins in Lubin D, Kouadio F, Melamed N. Post-term Kenigsberg S, Lima PDA, Maghen L, Vaginal Cells Derived from Premenopausal Pregnancy is an Independent Risk Factor Wyse BA, Lackan C, Cheung A, Tsang Women with Severe Pelvic Organ Prolapse. for Neonatal Morbidity Even in Low-risk B, Librach CL. The Elusive MAESTRO Reprod Sci. 2016 Aug;23(8):978-92. Singleton Pregnancies. Arch Dis Child Fetal Gene: Its Human Reproductive Tissue- Neonatal Ed. 2017 Jul;102(4):F286-F290. Lau E, Brophy J, Samson L, Kakkar F, specific Expression Patterns. PLoS Campbell D, Yudin MH, Murphy KE, Seto Lisonkova S, Mehrabadi A, Allen VM, Bujold One. 2017 Apr 13;12(4):e0174873.

82 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Original Research

E, Crane J, Gaudet L, Gratton RJ, Ladhani Methyldopa have Different Effects on Venous Thromboembolism in Obese NN, Olatunbosun OA, Joseph KS . Atonic Pregnancy Outcome? Analysis of Date from Pregnant Women: Approach to Diagnosis Postpartum Hemorrhage: Blood Loss, Risk the Control of Hypertension in Pregnancy and Management. Ginekologia Factors, and Third Stage Management. Study (CHIPS) Trial. British J of Obstet Polska. 2017;88(8):453-459. JOGC 2016: 38(12); 1081-1090. Gynecol. 2016 Jun; 123(7):1143-1151. Malinowski AK, Ananth CV, Catalano P, Liu B, Lee P. Unusual Perils of Pelvic Organ Magee LA, von Dadelszen P, Singer J, Lee Hines EP, Kirby RS, Klebanoff AM, Mulvihill Prolapse. JSOGC Vol 39, Issue 11, Nov T, Rey E, Ross S, Asztalos E, Murphy KE, JJ, Simhan H, Hamilton CM, Hendershot 2017, p 1038-1041. Epub 2017 Jul 18. Menzies J, Sanchez J, Gafni A, Helewa TP, Phillips MJ, Kilpatrick LA, Maiese M, Hutton E, Koren G, Lee SK, Logan DR, Ramos EM, Wright RJ, Dolan SM, for Lo CK, Kennedy VL, Yudin MH, Shapiro AG, Ganzevoort W, Welch R, Thornton the PhenX Pregnancy Working Group. HM, Loutfy M. Access to Fertility Services JG, Moutquin JM; CHIPS Study Group. Research Standardization Tools: Pregnancy in Canada for HIV-positive Individuals and The CHIPS Randomized Controlled Trial Measures in the PhenX Toolkit. Am J Obstet Couples: A Comparison Between 2007 and (Control of Hypertension in Pregnancy Gynecol. 2017 Sep;217(3):249-262. 2014. AIDS Care. 2017 Nov;29(11):1433- Study): Is Severe Hypertension Just an Martin LJ, Sjörs G, Reichman B, Darlow Lu L, Kingdom JC, Wang R, Burton Elevated Blood Pressure? Hypertension. BA, Morisaki N, Modi N, Bassler D, Mirea GJ, Cindrova-Davies T. Placental 2016 Nov;68(5):1153-1159. L, Adams M, Kusuda S, Lui K, Feliciano Stem Villus Arterial Remodeling Magee LA, von Dadelszen P, Singer LS, Håkansson S, Isayama T, Mori R, Associated with Reduced Hydrogen J, Lee T, Rey E, Ross S, Asztalos E, Vento M, Lee SK, Shah PS; International Sulphide Synthesis Contributes to Murphy KE, Menzies J, Sanchez J, Gafni Network for Evaluating Outcomes (iNeo) of Human Fetal Growth Restriction. Am A, Gruslin A, Helewa M, Hutton E, Lee Neonates Investigators. Country-Specific J Pathol. 2017 Apr;187(4):908-920. SK, Logan AG, Ganzevoort W, Welch R, vs. Common Birthweight-for-Gestational Luketic L, Shirreff L, Kives S, Solnik Thornton JG, Moutquin JM. Can Adverse Age References to Identify Small for MJ, Leyland N, Liu G, El Sugy R, Murji Maternal and Perinatal Outcomes be Gestational Age Infants Born at 24-28 A. Does Ulipristal Acetate Objectively Predicted when Blood Pressure Becomes weeks: An International Study. Paediatr Affect Surgical Experience at Laparoscopy Elevated? Secondary Analyses from Perinat Epidemiol. 2016 Sep; 30(5):450-61. Myomectomy. Journal of Minimally Invasive the CHIPS (Control of Hypertension Massumi M, Pourasgari F, Nalla A, Gynecology. 2017 Jul - Aug;24(5):797-802. in Pregnancy Study) Randomized Batchuluun B, Nagy K, Neely E, Gull R, Controlled Trial. Acta Obstet Gynecol Nagy A, Wheeler MB. An Abbreviated Magee LA, von Dadelszen P, Singer J, Lee Scand. 2016 Jul;95(7):763-76. T, Rey E, Ross S, Asztalos E, Murphy KE, Protocol for In Vitro Generation of Menzies J, Sanchez J, Gafni A, Gruslin Maghen L, Shlush E, Gat I, Felice M, Functional Human Embryonic Stem A, Helewa M, Hutton E, Koren G, Lee Barretto T, Jarvi K, Lo K, Gauthier- Cell-Derived Beta-Like Cells. PLoS SK, Logan AG, Ganzevoort JW, Welch Fisher A, Librach CL. Human Umbilical One. 2016 Oct 18;11(10):e0164457. R, Thornton JG, Moutquin J-M, CHIPS Perivascular Cells (HUCPVC’s): A Novel May T, Bouchard-Fortier G, Kim RH, Working Group (Seaward G). Control Source of Mesenchymal Stromal-like Allen, L, Gupta A. Fertility-sparing Surgery of Hypertension in Pregnancy Study Cells MSCs to Support the Regeneration for the Management of Young Women Randomized Controlled Trial – Are the of the Testicular Niche. Reproduction. with Embryonal Rhabdomyosarcoma Results Dependent on the Choice of 2016 Oct 25. pii: REP-16-0220. of the Cervix: A Case Series. Gynecol Labetalol or Methyldopa. British J of Obstet Mäkikallio K, Shah J, Slorach C, Qin Oncol Rep. 2016 Aug 26;18:4-7. Gynecol. 2016 Jun;123(7):1135-1141. H, Kingdom JC, Keating S, Kelly E, May T, Comeau R, Sune P, Kotsopoulos J, Magee LA, von Dadelszen P, Singer J, Lee Manlhiot C, Redington A, Jaeggi E. Fetal Narod S, Rosen B, Ghatage P. A Comparison T, Rey E, Ross S, Asztalos E, Murphy KE, Growth Restriction and Cardiovascular of Survival Outcomes in Advanced Menzies J, Sanchez J, Gafni A, Gruslin Outcome in Early Human Infancy: A Serous Ovarian Cancer Patients Treated A, Helewa M, Hutton E, Koren G, Lee Prospective Longitudinal Study. Heart with Primary Debulking Surgery Versus SK, Logan AG, Ganzevoort JW, Welch R, Vessels. 2016 Sep;31(9):1504-13. Neoadjuvant Chemotherapy. Int J Gynecol Thornton JG, Moutquin J-M, CHIPS Working Malinowski AK, Bomba-Opon´ D, Cancer. 2017 May;27(4):668-674. Group (Seaward G). Do Do Labetalol and Parrish J, Szrzyn´ska U, Farine D.

ANNUAL REPORT 2016/17 83

McLaughlin K, Baczyk D, Potts A, Twin Pregnancies Complicated by Report Card System For Gynaecologic Hladunewich M, Parker J, Kingdom JC. Preterm Birth. Am J Obstet Gynecol. Surgery Journal. J Obstet Gynaecol Low Molecular Weight Heparin Improves 2016 Oct;215(4):482.e1-9. Can. 2017 Apr;39(4):207-209. Endothelial Function in Pregnant Mei-Dan E, Chundalama J, Shah P, Shah Murji A, Shirreff L. Un Retour aux Women at High-risk of Preeclampsia. J, Lee SK, Murphy KE. The Effect of Années Révolues de Formation : Hypertension. 2017 Jan;69(1):180-188. Birth Order on Neonatal Morbidity and Plaidoyer pour un Système Uniforme de Melamed N, Pittini A, Barrett J, Shah Mortality in Very Preterm Twins. Am J Bulletins en Chirurgie Gynécologique. J, Yoon EW, Lemyre B, Lee SK, Murphy Perinatol. 2017 Jul;34(9):845-850. Journal of Obstetrics and Gynaecology KE, Shah P, the Canadian Neonatal Canada. 2017 April; 39(4) 210-212. Mitri F, Nayot D, Casper RF, Bentov Network Investigators. Antenatal Y. Current Tools for Optimization Murji A, Whitaker L, Chow TL, Sobel Corticosteroids and Outcomes of Small- of Embryo Transfer Technique for ML. Selective Progesterone Receptor for-Gestational-Age Neonates. Obstet Recurrent Implantation Failure. Minerva Modulators (SPRMs) for Uterine Fibroids. Gynecol. 2016 Nov(5)128: 1001-1008. Ginecol. 2016 Aug;68(4):431-49. Cochrane Database of Systematic Melamed N, Shah J, Yoon EW, Pelausa E, Reviews 2017 Apr; 26 (4); CD010770. Money DM, Moses E, Blitz S, Vancriel Lee SK, Shah PS, Murphy KE; Canadian SM, Lipsky N, Walmsley SL, Loutfy M, Nadeem L, Shynlova O, Matysiak-Zablocki Neonatal Network Investigators. The Trottier S, Smaill F, Yudin MH, Klein M, E, Mesiano S, Dong X, Lye S. Molecular Role of Antenatal Corticosteroids in Harris M, Cohen J, Wobeser W, Bitnun Evidence of Functional Progesterone Twin Pregnancies Complicated by A, Lapointe N, Samson L, Brophy J, Withdrawal in Human Myometrium. Preterm Birth. Am J Obstet Gynecol. Karatzios C, Ogilvie G, Coutlee F, Raboud. Nat Commun. 2016 May 25;7:11565. 2016 Oct;215(4):482.e1-9. HIV Viral Suppression Results in Higher Nevis IF, Vali B, Higgins C, Dhalla I, Melamed N, Pittini A, Hiersch L, Yogev Antibody Responses in HIV-positive Urbach D, Bernardini MQ. Robot-assisted Y, Korzeniewski SS, Romero R, Barrett Women Vaccinated with the Quadrivalent Hysterectomy for Endometrial and J. Serial Cervical Length Determination Human Papillomavirus Vaccine. Vaccine. Cervical Cancers: A Systematic Review. in Twin Pregnancies Reveals 4 2016 Sep 14;34(40):4799-806. J Robot Surg. 2017 Mar;11(1):1-16. Distinct Patterns with Prognostic Morency AM, Shah PG, Seaward PG, Significance for Preterm Birth. Am J Nguyen J, Bouchard-Fortier G, Shah PS, Murphy KE. Obstetrical and Obstet Gynecol. 2016 Oct;215(4):476 Bernardini MQ, Atenafu E, Han G, Neonatal Outcomes of Triplet Births – Vicus D, Ferguson SE, Gien L. Uterine Melamed N, Pittini A, Hiersch L, Yogev Spontaneous versus Assisted Reproductive Clear Cell Carcinoma: Does Adjuvant Y, Korzeniewski SJ, Romero R, Barrett Technology Conception. J Matern Fetal Chemotherapy Improve Outcomes? Int J J. Do Serial Measurements of Cervical Neonatal Med. 2016 Mar;29(6):938-43. Gynecol Cancer. 2017 Jan;27(1):69-76. Length to Improve the Prediction of Moretti ME, Lato DF, Berger H, Koren Preterm Birth in Asymptomatic Women Nitschmann C, May T, Feldman S. G, Ito S, Ungar WJ. A Cost-effectiveness with Twin Gestations? Am J Obstet Screening History Among Women with Analysis of Maternal CYP2D6 Genetic Gynecol. 2016 Nov;215(5):616.e1-616 Invasive Cervical Cancer in an Academic Testing to Guide Treatment for Postpartum Medical Center: Will we Miss Cancers Melamed N, Pittini A, Barrett J, Shah Pain and Avert Infant Adverse Events. Following Updated Guidelines? J Womens J, Yoon EW, Lemyre B, Lee SK, Murphy Pharmacogenomics J. 2017 Jul 11. Health. 2016 Aug;25(8):826-31. KE, Shah PS; Canadian Antenatal Morris S, Yudin MH, Callum J, Corticosteroids and Outcomes of Nucci AM, Virtanen SM, Sorkio S, Bärlund Alam A, Herold J, Lin Y. Obstetrical Small-for-Gestational-Age Neonates. S, Cuthbertson D, Uusitalo U, Lawson Transfusion Medicine Knowledge Among Neonatal Network Investigators. ML, Salonen M, Berseth CL, Ormisson Faculty and Trainee Obstetricians: A Obstet Gynecol. 2016 Nov;128(5). A, Lehtonen E, Savilahti E, Becker DJ, Prospective Knowledge Assessment Dupré J, Krischer JP, Knip M, Åkerblom Melamed N, Shah J, Yoon EW, Pelausa E, Study. Trans Med 26(6);440-7:2016. HK, Sermer M; TRIGR Investigators. Lee SK, Shah PS, Murphy KE; Canadian Murji A, Shirreff L. A Return to Training Regional Differences in Milk and Neonatal Network Investigators. The Days Gone By: A Case For a Uniform Complementary Feeding Patterns in Role of Antenatal Corticosteroids in

84 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Original Research

Infants Participating in an International Dis. 2016 May 15;213(10):1532-40. and Newborn Infants. Matern Child Nutr. Nutritional Type 1 Diabetes Prevention 2017 May 24. [Epub ahead of print] Paterson N, Shara AM, Maxwell C, Trial. Matern Child Nutr. 2017 Jul;13(3). Greenblatt EM. Obesity Related Po L, Lee P. The Unintended Nguyen-Lu N, Carvalho JC, Kingdom Health Status is a Better Predictor of Consequences of an FDA warning: the JC, Windrim R, Allen L, Balki M. Mode Pregnancy with Fertility Treatment than case of Power Morcellation in Myoma of Anesthesia and Clinical Outcomes of Body Mass Index: A Prospective Study. Surgery. J Minim Invasive Gynecol. Patients Undergoing Caesarean Delivery Clin Obes. 2016 Aug;6(4):243-8. 2016 May-Jun;23(4):597-602 for Invasive Placentation: A Retrospective Payne SL, Anandakumaran PN, Varga Poliquin V, Wylie J, Cole R, Yudin MH, Cohort Study of 50 Consecutive Cases. BV, Morshead CM, Nagy A, Shoichet Van Caesseele P. Preparedness for Can J Anaesth. 2016 Nov;63(11):1233-44. MS. In Vitro Maturation of Human Implementing Change in Neonatal Nguyen T, Shynlova O, Lye S. Matrix iPS-derived Neuroepithelial Cells Ocular Prophylaxis Policies. J Obstet Metalloproteinase Expression in the Influences Transplant Survival in the Gynaecol Can 38(1);7-8:2016. Rat Myometrium during Pregnancy, Stroke-injured Rat Brain. Tissue Eng Part Pulman K, Dason E, Philp L, Bernardini Term Labour, and Postpartum. Biol A. 2017 Jun 8. [Epub ahead of print] MQ, Ferguson S, Laframboise S, Atenafu Reprod. 2016 Jul;95(1):24. Pham A, Melchior M. Five Things E, May T. Comparison of Three Surgical Palacio M, Ronzoni S, Sanchez L, Murphy to Know About...Screening for Fetal Approaches for Staging Lymphadenectomy KE. Progestogens as Maintenance Congenital Heart Disease. CMAJ in High-Risk Endometrial Cancer. Int J Treatment in Arrested Preterm Labor: A March 27, 2017; 189 (12): E468. Gynaecol Obstet. 2017 Mar;136(3):315-319. Systematic Review and Meta-analysis. Phelan CM, Kuchenbaecker KB, Tyrer JP, Quinn KL, Osmond M, Badiwala M, Obstet Gynecol. 2016 Nov;128(5):989-1000. Kar SP, Lawrenson K, Winham SJ, Dennis Sermer M, Lapinsky SE. Severe Palacio M, Cobo T, Antolin E, Ramirez J, Pirie A, Riggan MJ, Chornokur G, Earp Staphylococcus Aureus Endocarditis M, Cabrera F, Mozo de Rosales F, Bartha MA, Lyra PC Jr, Lee JM, Coetzee S, Beesley Presenting as Peripartum Thrombotic JL, Juan M, Murphy KE, Marti A, Oros D, J, McGuffog L, Soucy P, Dicks E, Lee A, Thrombocytopenic Purpura J Obstet Rodriquez A, Scazzocchio E, Olivares JM, Barrowdale D, Lecarpentier J, Leslie G, Gynaecol Can 2016 Nov;38(11):1028-1032. Varea S, Rios J, Gratacos E on behalf of Aalfs CM, Aben KKH, Adams M, Adlard J, Rahman A, Zhou YQ, Yee YY, Dazai J, the PROMISE Collaborative Group. Vaginal Andrulis IL, Anton-Culver H, Antonenkova Cahill LS, Kingdom JC, Macgowan C, Progesterone as Maintenance Treatment N; AOCS study group, Aravantinos G, Arnold Sled J. Ultrasound Detection of Altered after an Episode of Preterm Labour N, Arun BK, Arver B, Azzollini J, Balmaña J, Placental Vascular Morphology Based (PROMISE Study): A Multicentre, Double- Banerjee SN, Barjhoux L, Barkardottir RB, on Hemodynamic Pulse Wave Reflection. blind, Randomized, Placebo-controlled Bean Y, Beckmann MW, Beeghly-Fadiel A, Am J Physiol Heart Circ Physiol. 2017 Trial. BJOG. 2016 Nov;123(12):1990-1999. Benitez J, Bermisheva M, Bernardini MQ, May 1;312(5):H1021-H1029. Birrer MJ, Bjorge L, Black A, Blankstein K, Papillon-Smith J, Sobel ML, Niles Blok MJ, Bodelon C, Bogdanova N, Bojesen Ray JG, De Souza LR, Park AL, Connelly KM, Solnik MJ, Murji A. Surgical A, Bonanni B, Borg Å, Bradbury AR, Brenton PW, Bujold E, Berger H. Preeclampsia and Management Algorithm for Caesarean JD, Brewer C, Brinton L, Broberg P, Brooks- Preterm Birth Associated with Visceral Scar Pregnancy. J Obstet Gynaecol Wilson A, Bruinsma F, Brunet J, Buecher Adiposity in Early Pregnancy. J Obstet Can. 2017 Jun 7. pii: S1701-2163. B, Butzow R, May T, et al. Identification Gynaecol Can. 2017 Feb;39(2):78-81. Papp E, Balogun K, Banko N, Mohammadi H, of 12 New Susceptibility Loci for Different Ranzini AC, Hyman F, Jamaer E, Van Loutfy M, Yudin MH, Shah R, MacGillivray Histotypes of Epithelial Ovarian Cancer. Mieghem T. Aberrant Right Subclavian J, Murphy KE, Walmsley SL, Silverman Nat Genet. 2017 May;49(5):680-691. Artery: Correlation with Fetal and M, Serghides L. Low Prolactin and High Plumptre L, Masih SP, Sohn KJ, Kim D, Neonatal Abnormalities. J Ultrasound 20-α-hydroxysteroid Dehydrogenase Visentin CE, Ly A, Berger H, Croxford Med 2017 Apr;36(4)785-790. Levels Contribute to Lower Progesterone R, O’Connor DL, Kim YI. Suboptimal Levels in HIV-infected Pregnant Women Maternal and Cord Plasma Pyridoxal 5’ Rennie MY, Whiteley KJ, Adamson SL, Exposed to Protease Inhibitor-based Phosphate Concentrations are Uncommon Sled JG. Quantification of Gestational Combination Antiretroviral Therapy. J Infect in a Cohort of Canadian Pregnant Women Changes in the Uteroplacental

ANNUAL REPORT 2016/17 85

Vascular Tree Reveals Vessel Specific Magn Reson. 2017 Mar 20;19(1):29. Newborn, Child and Adolescent Health: Hemodynamic Roles during Pregnancy in A Research Prioritization Exercise. CMAJ Russo FM, Eastwood MP, Keijzer R, Mice. Biol Reprod. 2016 Aug;95(2):43. Open. 2017 Jan 31;5(1):E82-E89. Al-Maary J, Toelen J, Van Mieghem T, Retnakaran R, Ye C, Connelly PW, Hanley AJ, Deprest JA. Lung Size and Liver Herniation Shathasivam P, Kollara A, Spybey T, Park S, Sermer M, Zinman B. Impact of Changes Predict the Need for Extra Corporeal Clarke B, Ringuette MJ, Brown TJ. VEPH1 over Time in Adipokines and Inflammatory Membrane Oxygenation but not Pulmonary Expression Decreases Vascularisation in Proteins on Changes in Insulin Sensitivity, Hypertension in Isolated Congenital Ovarian Cancer Xenografts and Inhibits β-Cell Function, and Glycemia in Women Diaphragmatic Hernia: A Systematic VEGFA and IL8 Expression through with Previous Gestational Dysglycemia. Review and Meta-analysis. Ultrasound Inhibitation of AKT Activation. Br J Diabetes Care. 2017 Aug;40(8):e101e102. Obstet Gynecol. 2017 June;49(6):704-713. Cancer. 2017 Apr 11;116(8):1065-1076.

Retnakaran R, Ye C, Kramer CK, Connelly Salem SY, Kibel M, Asztalos E, Zaltz A, Shea AK, Simpson A, Barrett J, Ladhani PW, Hanley AJ, Sermer M, Zinman B. Barrett J, Melamed N. Neonatal Outcomes NN, Nevo O. Pregnancy Outcomes of Women Maternal Serum Prolactin and Prediction of Low-Risk, Late-Preterm Twins Compared Admitted to a Tertiary Care Centre with of Postpartum β-Cell Function and with Late-Preterm Singletons.Obstet Short Cervix. JOGC 2017 39(5); 328-334 Risk of Prediabetes/Diabetes. Diabetes Gynecol. 2017 Sep;130(3):582-590. Shehata N, Chasse M, Colas JA, Murphy Care. 2016 Jul;39(7):1250-8. Sambi M, Chow T, Whiteley J, Li M, Chua M, Forster AJ, Malinowski AK, Ducharme Retnakaran R, Ye C, Kramer CK, S, Raileanu V, Rogers IM. Acellular R, Fergusson DA, Shlush E, Maghen L, Connelly PW, Hanley AJ, Sermer M, Mouse Kidney ECM can be Used as a Swanson S, Kenigsberg S, Moskovtsev Zinman B. Evaluation of Circulating Three-dimensional Substrate to Test the SI, Barretto T, Gauthier-Fisher A, Librach Determinants of Beta-Cell Function in Differentiation Potential of Embryonic Stem CL. In Vitro Generation of Sertoli-like and Women with and without Gestational Cell Derived Renal Progenitors. Stem Cell Haploid Spermatid-like Cells from Human Diabetes. J Clin Endocrinol Metab. Rev and Rep. 2017 Aug. 13(4):513-531. Umbilical Cord Perivascular Cells. Stem Cell 2016 Jul; 101(7):2683-91. Research and Therapy. 2017 Feb 15;8(1):37. Sehmbi H, D’Souza R, Bhatia A. Rich R, D’Hont T, Linton J, Murphy KE, A Narrative Review of Low Back Shehata N, Chasse M, Colas JA, Murphy Veillard J, Chatwood S. Performance Pain in Pregnancy: Investigations, M, Forster AJ, Malinoski AK, Ducharme R, Indicators for Maternity Care in a Management, and Role of Neuraxial and Fergusson DA, Tinmouth A, Wilson K. Risks Circumpolar Context: A Scoping Review. Int Anesthesia. Gynaecologic and Obstetric and Trends of Red Blood Cell Transfusion in J Circumpolar Health. 2016 Dec 9;75:31470. Investigation. 2017;82(5):417-436. Obstetric Patients: A Retrospective Study of 45,213 Deliveries Using Administrative Rosen H, Hiersch L, Freeman H, Shah PS, Lui K, Sjörs G, Mirea L, Data. Transfusion. 2017;57(9):2197-2205. Barrett J, Melamed N. The Role of Reichman B, Adams M, Modi N, Darlow Serial Measurements of Cervical BA, Kusuda S, San Feliciano L, Yang Shlush E, Maghen L, Swanson S, Length in Asymptomatic Women with J, Håkansson S, Mori R, Bassler D, Kenigsberg S, Moskovtsev SI, Barretto Triplet Pregnancy. J Matern Fetal Figueras-Aloy J, Lee SK; International T, Gauthier-Fisher A, Librach CL. In Vitro Neonatal Med. 2017 Mar 9:1-7 Network for Evaluating Outcomes (iNeo) Generation of Sertoli-like and Haploid of Neonates. Neonatal Outcomes of Spermatid-like Cells from Human Umbilical Ronzoni S, Keunen J, Arnold D, Smith J, Very Low Birth Weight and Very Preterm Cord Perivascular Cells. Stem Cell Research Ryan G. Antenatal Management of Fetal Neonates: An International Comparison. and Therapy. 2017 Feb 15;8(1):37. Neonatal Alloimmune Thromocytopenia J Pediatr. 2016 Oct;177:144-152.e6. (FNAIT) and Neonatal Outcome According Shore EM, Grantcharov TP, Husslein to the Category of Risk. Ultrasound Obstet Sharma R., Buccioni M., Gaffey M.F., H, Shirreff L, Dedy NJ, McDermott Gynecol. 2016 Sep;48 Suppl 1:357. Mansoor O., Scott H. and Bhutta Z.A; CD, Lefebvre GG. Validating a Canadian Expert Group on Maternal, Standardized Laparoscopy Curriculum for Roy C, Seed M, Kingdom JC, Macgowan C. Newborn, Child and Adolescent Health Gynaecology Residents: A Randomized Motion Compensated CINE Imagine of the (Bocking A). Setting an Implementation Controlled Trial. Am J Obstet Gynecol. Fetal Heart Using Radial Undersampling Research Agenda for Canadian 2016 Aug;215(2):204.e1-204.e11. and Compressed Sensing. J Cardiovasc Investments in Global Maternal

86 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Original Research

Siou K, Walmsley SL, Murphy KE, Raboud of First Trimester Human Umbilical MP, Ray JG. Low Rates of Aspirin Use for J, Loutfy M, Yudin MH, Silverman M, Cord Perivascular Cells into Contracting the prevention of Preeclampsia. J Obstet Ladhani NN, Papp E, Serghides L. Erratum Cardiomyocyte-like Cells. Stem Cells Gynaecol Can. 2017 Sep;39(9):722-723. to: Progesterone Supplementation for International. 2016:7513252 Viguiliouk E, Park A, Berger H, Geary M, HIV-positive Pregnant Women on Protease Smy L, Shaw K, Amstutz U, Smith A, Ray JG. A Simple Clinical Method to Identify Inhibitor-based Antiretroviral Regimens Berger H, Carleton B, Koren G. Hair Women at Higher Risk of Preeclampsia. (the ProSPAR Study): A Study Protocol Cortisol as a Hypothalamic-pituitary- Pregnancy Hypertens. 2017 Oct;10:10-13. for a Pilot Randomized Controlled Trial. adrenal Axis Biomarker in Pregnant Pilot Feasibility Stud. 2017 Apr 28;3:21. Vilos G, Ternamian A, Vilos A, Abu-Rafea, Women with Asthma: A Retrospective Cici Z. Direct Laparoscopic Trocar Insertion: Sivarajah V, Venus K, Yudin MH, Murphy Observational Study. BMC Pregnancy Lessons Learned from Nine Litigated Cases. KE, Morrison SA, Tan DHS. Does Maternal Childbirth. 2016 Jul 20;16(1):176. . J Mini Ivasiv Gyneecol. 2017; 24(6):960-70. HSV-2 Coinfection Increase Mother-to- Vachon-Marceau C, Demers S, Markey S, child Transmission of HIV? A systematic Wais M, Lee S, Liu G, Pham A, Tai M, Murji Okun N, Girard M, Kingdom JC, Bujold review. 2017 Dec;93(8):535-542. A. Surgical Experience with Ullipristal E. First-trimester Placental Thickness Acetate or Gnadotropin Releasing Hormone Souders CP, Catchpole KR, Wood LN, and the Risk of Preeclampsia or SGA. Agonist for Uterine Fibroids. J Minim Solnik MJ, et al. Reducing Operating Placenta. 2017 Sep;57:123-128. Invasive Gynecol. 2016 November. Room Turnover Time for Robotic Surgery Vannevel V, Jans G, Bialecka M, Lannoo Using a Motor Racing Pit Stop Model. Walker M, Pollard L, Talati C, Carvalho J, M, Devlieger R, Van Mieghem T. World J Surg. 2017 Aug;41(8):1943-1949. Allen L, Kachura J, Murji A, Kingdom JC, Internal Herniation in Pregnant Women Windrim R. Obstetric and Anaesthesia Srivaratharajah K, Abramson BL, Jairam with a History of Gastric Bypass: Checklists for the Management of Morbidly J, Park AL, Berger H, Ray JG. Ethnic Systematic Literature Review. Obstet Adherent Placenta. J Obstet Gynecol Differences in Visceral Adiposity Measured Gynecol. 2016 Jun;127(6):1013-20. Can. 2016 Nov;38(11):1015-1023. in Early Pregnancy. J Obstet Gynaecol Can. Van Nguyen JM, Bouchard-Fortier G, 2017 Sep 20. pii: S1701-2163(17)30502-9. Wallis CJD, Cheung DC, Garbens A, Ferguson SE, Covens A. How Common is Kroft J, Carr L, Nathens AB, Po L, Stewart DE, Vigod SN, MacMillan HL, Growing Teratoma Syndrome in Patients Nam RK, Liu G, Gien L, Satkunasivam Chandra PS, Han A, Rondon MB, MacGregor with Ovarian Immature Teratoma? Int J R. Occurrence of and Risk Factors for JCD, Riazantseva E. Current Reports on Gynecol Cancer. 2016 Sep;26(7):1201-6. Urological Intervention During Benign Perinatal Intimate Partner Violence. Curr Van Mieghem T, Doherty A, Drewlo S, Hysterectomy – Analysis of the National Psychiatry Rep. 2017 May; 19(5): 26. Baczyk D, Baud D, Carvalho J, Kingdom Surgical Quality Improvement Program Sun D, Shehata N, Ye XY, Gregorovich S, De JC. Apelin in Normal Pregnancy Database. Urology. 2016 Nov; 97: 66-72. France B, Arnold D, Shah P, Malinowski AK. and Pregnancies Complicated by Weiner E, Kahn M, Giltvedt K, Kibel M, Corticosteroids Compared with Intravenous Placental Insufficiency. Reprod Sherman C, Kingdom JC, Barrett J, Immunoglobulin for the Treatment of Sci. 2016 Aug;23(8):1037-43. Melamed N. Nonpresenting Dichorionic Immune Thrombocytopenia in Pregnancy. Vidler M, Magee LA, von Dadelszen P, Rey Twins and Placental Vascular Malperfusion. Blood. 2016;128(10):1329-1335. E, Ross S, Asztalos E, Murphy KE, Menzies Obstet Gynecol. 2017 Jun;129(6):1109-1117. Swartz RH, Cayley ML, Foley N, Ladhani J, Sanchez J, Singer J, Gafni A, Gruslin A, Willows K, Lennox G, Covens A. NN, Leffert L, Bushnell C, McClure JA, Helewa M, Hutton E, Lee SK, Lee T, Logan Fertility-sparing Management in Cervical Lindsay MP. The Incidence of Pregnancy- AG, Ganzevoort W, Welch R, Thornton JG, Cancer: Balancing Oncologic Outcomes related Stroke: A Systematic Review and Moutquin JM; CHIPS Study Group. Women’s with Reproductive Success. Gynecol Meta-analysis. International Journal Views and Postpartum Follow-up in the Oncol Res Pract. 2016 Oct 21;3:9. of Stroke 2017: 12(7); 687-697. CHIPS Trial (Control of Hypertension in Pregnancy Study). Eur J Obstet Gynecol Windrim R, Kingdom JC, Jang HJ, Burns Szaraz P, Iqbal F, Librach M, Maghen L, Reprod Biol. 2016 Nov;206:105-113. PN. Contrast Enhanced Ultrasound (CEUS) Barretto T, Kenigsberg S, Gauthier-Fisher in the Prenatal Evaluation of Suspected A, Librach CL. In Vitro Differentiation Viguiliouk E, Park AL, Berger H, Geary Invasive Placenta Percreta. J Obstet

ANNUAL REPORT 2016/17 87 Original Research

Gynaecol Can. 2016 Oct;38(10):975-978. Zipori Y, Berger H, Colak E, Geary M. Pyogenic Liver Abscess with Atypical Xu J, Sivasubramaniyam T, Yinon Y, Microbiology during Pregnancy: A Tagliaferro A, Ray J, Nevo O, Post M, Case Report. J Obstet Gynaecol. Caniggia I. Aberrant TGFß Signalling 2017 Aug;37(6):827-828. Contributes to Altered Trophoblast Differentiation in Preeclampsia. Zohni KM, Gat I, Librach CL. Endocrinology. 2016 Feb;157(2):883-99. Recurrent Implantation Failure: A Comprehensive Review. Minerva Yaniv-Salem S, Zipori Y, Prabhudesai ginecologica. 2016 Dec;68(6):653-67. V, Faughan M, Berger H, Geary M. Hereditary Hemorrhagic Telangiectasia Zipori Y, Geary M, Wong H, Berger with Atypical Pulmonary Arteriovenous H. Nontuberculous Mycobacterium Malformation during Advanced Pregnancy during Pregnancy: A Case Report. - A Case Report. Journal Clin Med Case Journal of Transmitted Diseases Stud. 2017 January: 2(1): 15-18. and Immunity. 2017 Jan: 1(13).

Yougbare I, Tai WS,Zdravic D, Oswald BE, Zipori Y, Haas J, Berger H, Barzilay E. Lang S, Zhu G, Leong-Poi H, Dawei Q, Yu Multifetal Pregnancy Reduction of Triplets L, Dunk C, Zhang J, Sled JG, Lye SJ, Brkic to Twins Compared with Non-reduced J, Peng C, Hoglund P, Croy A, Adamson SL, Triplets: A Meta-analysis. Reprod Biomed Freedman J, Ni H. Activated NK Cells Cause Online. 2017 Sep;35(3):296-304. Placental Dysfunction and Miscarriages Zipori Y, Haas J, Berger H, Barzilay in Fetal Alloimmune Thrombocytopenia. E. Multifetal Reduction of Triplets to Nat Commun. 2017 Aug 9;8(1):224. Twins Compared with Non-reduced Yousuf AA, Frecker H, Satkunaratnam Twins: A Meta-analysis. Reprod Biomed A, Shore EM. The Development Online. 2017 Jul;35(1):87-93. of a Retroperitoneal Dissection Model. Am J Obstet Gynecol. 2017 Oct;217(4):483.e1-483.e3.

Yudin MH, Kennedy VL, MacGillivray SJ. HIV and Infant Feeding in Resource- rich Settings: Considering the Clinical Significance of a Complicated Dilemma. AIDS Care. 28(8);1023-6:2016.

Yudin MH, Mistry N, De Souza LR, Besel K, Patel V, Blanco Mejia S, Bernick R, Ryan V, Urquia M, Beigi RH, Moniz MH, Sgro M. Text Messages for Influenza Vaccination Among Pregnant Women: A Randomized Controlled Trial. Vaccine 35(5);842-8:2017.

Zhang J, Shynlova O, Sabra S, Bang A, Briollais L, Lye S. Immunophenotyping and Activation Status of Maternal Peripheral Blood Leukocytes during Pregnancy and Labor, Both Term and Preterm. J Cell Mol Med. 2017 Oct;21(10):2386-2402.

88 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY CLINICAL PRACTICE GUIDELINES

Armson BA, Allan DS, Casper Wolfson A, Yashar C, Bosch W. BMJ Best Practice. BMJ Publishing RF. Sang de Cordon Ombilical: Consensus Recommendations for Group, November 2017. Counseling, Prévèvement at Mise Radiation Therapy Contouring and Wilson RD, De Bie I, Armour en Banque. J Obstet Gynaecol Can. Treatment of Vulvar Carcinoma. CM, Brown RN, Campagnolo C, 2016 Dec; 38)12S):S724-S739. Int J Radiat Oncol Biol Phys. Carroll JC, Okun N, Nelson T, July 2016: 15;95(4):1191-200. Audibert F, De Bie I, Johnson Zwingerman R, Audibert F, Brock JA, Okun N, Wilson RD, Klionsky DJ, Caniggia I, et JA, Johnson JA, Pastruck M, Vallee- Armour C, Chitayat D, Kim R. al. Guidelines for the Use and Pouliot K, Chitayat D, Fernanadez No. 348-Joint SOGC-CCMG Interpretation of Assays for S, Ki R, Lavoie J, Leonard N, Taylor Guideline: Update on Prenatal Monitoring Autophagy (3rd S, Van Allen M, Van Karnebeek C. Screening for Fetal Aneuploidy, Fetal edition). Autophagy. January Guideline: Joint SOGC – CCMG Anomalies, and Adverse Pregnancy 2016: 2;12(1): p 1-222. Opinion for Reproductive for Outcomes. J Obstet Gynaecol Reproductive Genetic Career Ladhani NN, Chari RS, Dunn MS, Can 2017: 39 (9): p 805-817. Screening: An Update for All Jones G, Shah PS, Barrett J. SOGC Canadian Providers of Maternity Castillo E, Murphy KE, van Clinical Practice Guideline No. 347: and Reproductive Healthcare in Schalkwyk J, Allen V, Bouchard Obstetric Management at Borderline the Era of Direct-to-Consumer C, Boucher M, Boucoiran I, Viability. J Obstet Gynaecol Testing. J Obstet Gynaecol Can. Caddy S, Kennedy L, Money D, Can 2017: 39 (9): p 781-791. August 2016: 38(8): p 742-62. Ogilvie G, Paquet C, Poliquin Maxwell C, McGeer A, Tai FKY, V, Yudin MH. Hepatitis B and Sermer M. Nº 225-Management Pregnancy. SOGC Clinical Practice Guidelines for Obstetric Patients Guideline. J Obstet Gynaecol and Neonates Born to Mothers Can 2017: 39 (3): p 181-190. with Suspected or Probable Severe Croke J, Fyles A, Barbera L, Acute Respiratory Syndrome D’Souza D, Pearcey R, Stuckless (SARS). J Obstet Gynaecol Can. T, Bass B, Brundage M, Milosevic August 2017: 39(8):e130-e137. M. Radiotherapy Quality-of-Care Maxwell C, McGeer A, Tai Indicators for Locally Advanced KFY, Sermer M. Nº 225-Lignes Cervical Cancer: A Consensus Directrices Quant à la Prise en Guideline. Pract Radiat Oncol. Charge des Patientes en Obstétrique September 2016: 6(5): p 315-23. Chez Lesquelles la Présence du Ferguson S. Cancer Care Ontario Sundrome Respiratoire Aigu Sévère Ovarian Cancer Pathway Map. (SRAS) est Soupçonnée ou probable, Cancer Care Ontario; 2016 Nov 9. et des Nouveau-nés Issus de ces Patientes. J Obstet Gynaecol Can. Ferguson S. Cancer Care Ontario August 2017: 39(8):e121-e129. Interventions to Address Sexual Problems in People with Cancer. Solnik MJ. Cervicitis. BMJ Cancer Care Ontario; 2016 Jul 15. Best Practice. BMJ Publishing Group, November 2017. Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel Solnik MJ. Endometriosis. BMJ P, Erickson B, Fyles A, Goulart Best Practice. BMJ Publishing J, Harkenrider M, Jhingran Group, November 2017. A, Klopp A, Koh WJ, Lim K, Solnik MJ, Papillon-Smith J. Petersen I, Portelance L, Small Evaluation of Primary Amenorrhea. W Jr, Stewart A, Wiebe E,

ANNUAL REPORT 2016/17 89 BOOKS & BOOK CHAPTERS

Allegaert K, Van Mieghem T, Van den Extracellular Vesicles. Humana Press, Practical Manual for Laparoscopic Anker JN. Safety of Medications During New York, August 2017. p. 321-341. and Hysteroscopic Gynecological Pregnancy and Breastfeeding: Infants of Surgery, 3rd Edition. Jaypee, 2017. Kibschull M, Lye S, Shynlova O. Chapter Drug-Addicted Mothers. In: Buonocore 6: Generation and Use of Trophoblast Van Mieghem T, Russo F, Engels A, De G, Bracci R, Weindling M, editors. Stem Cells and Uterine Myocytes to Study Catte L, Devlieger R, Lewi L, Deprest J. Neonataology: A Practical Approach to the Role of Connexins for Pregnancy Chapter 26: Congenital diaphragmatic Neonatal Diseases. Springer International and Labor. In: Vinken M, Johnston SR, hernia. In: Copel J, D’Alton ME, Feltwich H, Publishing Switzerland, 2016. editors. Gap Junction Protocols. Springer Gratacos E, Krakow D, Anthony O, Lawrence Chow T, Mueller S and Rogers IM. Protocols, May 2016; 1(1437): p. 83-95. P, Tutschek B, editors. Obstetric Imaging: Chapter 8: Advances in Umbilical Cord Fetal Diagnosis and Care 2nd Edition. Malinowski AK, Parrish J. Venous Blood Therapy: Hematopoietic Stem Philadelphia: Elsevier, September 2017. Thromboembolism in the Obese Pregnant Cell Transplantation and Beyond. In: Patient. In: Maxwell C, Farine D, editors. El-Badri N, editor(s). Advances in Stem Obesity Before and In Pregnancy. Cell Therapy. Bench to Bedside. Series: Canada: De Gruyter, October 2017. Stem Cell Biology and Regenerative Medicine. 1st, XV. Humana: Press Springer Maxwell CV. Chapter 17: Maternal International Publishing Switzerland, Fetal Medicine: Obesity and Academic September 2016. p. 139-168. Challenges. In: Fymat AL, Kapalanga J, editors. Science Research and Farine D, Farine J, Farine T. The World’s Education in Africa: Proceedings of a Shortest Bedtime Stories. New Century Conference on Science Advancement. Schoolbook, First Edition, 2016, p. 1-120. United Kingdom: Cambridge Scholars Fisher BM, Yudin MH. Other Infectious Publishing, February 2017. p. 248-254. Conditions. In: James D, Steer PJ, Weiner Melamed N, Kennedy A, Glanc P. Chapter CP, Gonik B, Robson SC, editors. High Risk 38: The Fetal Abdominal Wall and Pregnancy: Management Options, 5th Gastrointestinal Tract. In: Rumack C, Levine edition, Elsevier; May 2016. p. 729-77. D, editors. Diagnostic Ultrasound, 2-Volume Hershko-Klement A, Casper RF. Chapter Set, 5th Edition. Elsevier, August 2017. 16: Treatment of WHO II: Aromatase Rosen H, Hodges, R, Malvasi, A, Tinelli, Inhibitors. In: Cohlen BJ, Van Santbrink A, Farine D. Marinelli E. Chapter 10: E, Laven J, editors. Ovulation Induction: Operative Vaginal Delivery In: Malvasi A, Evidence Based Guidelines for Daily Tinelli A, Di Renzo GC, editors. Management Practice. CRC Press, July 2016. and Therapy of Late Pregnancy Jacquemyn Y, Van Mieghem T, Complications. Springer International Devlieger R. Arbeid, vaginale bevalling, Publishing, June 2017. p. 145-166. keizersnede en de belangrijkste Selk A, editor. Obstetrics. In: zwangerschapscomplicaties. In: The Toronto Notes, 2016. Anesthesie en Analgesie in de normale zwangerschap. Acco, 2017. Spitzer R, Thistle P. Chapter 15: Obstetrics and Gynaecology. In: Arya Kenigsberg S, Wyse BA, Librach CL, AK, editor. Preparing for International da Silveira JC. Chapter 26: Protocol for Health Experiences: A Practical Guide. Exosome Isolation from Small Volume Ed. New York: CRC Press, June 2017. of Ovarian Follicular Fluid: Evaluation of Ultracentrifugation and Commercial Kits. Ternamian A. Chapter 6: Risk Management In: Kuo WK, Jia S, editors. Extracellular in Endoscopic Surgery. In: Schollmeyer T, Vesicles, Methods and Protocols. Ruther D, Mettler L, Alkatout I, editors.

90 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Invited Lectures & Visiting Professorships

ANNUAL REPORT 2016/17 91 INTERNATIONAL LECTURES

Aggarwal A. The Ethics and Placenta and Sociedad Ovarian Club. Paris, Screening, Prevention, of Consent in Pediatric Chilena de Ciencias Fisiológicas France, November 2016. Early Diagnosis – North Gynaecology. North American joint meeting. Puerto American Data. International Casper R. Is There Society for Paediatric Varas, Chile, April 2017. Gynaecologic Cancer Society. Scientific Evidence for Gynaecology, Annual Lisbon, Portugal, October 2016. Casper R. Clinical Application Enhancing Mitochondrial Clinical Meeting. Chicago, of Autologous Mitochondrial Activity in IVF? Best of Covens A. Interactive Tumour IL, USA, April 2017. Injections. European Society European Society of Human Board – Cervical Cancer. Allen L. Ovarian Torsion. of Human Reproduction and Reproduction Embryology International Gynaecologic American Academy of Embryology, Annual Meeting. and the American Society Cancer Society. Lisbon, Pediatrics, Surgical Section Helsinki, Finland, July 2016. for Reproductive Medicine. Portugal, October 2016. Symposium. San Francisco, Paris, France, February 2017. Casper R. Mitochondria as a Covens A. HPV: More than CA, USA, October 2016. Source of Energy in Cumuli, Casper R. Discussion of Cervical Cancer. Society of Allen L. Menstrual and Oocytes, and Embryos and the my Career in REI. Roskilde, Gynecologic Oncology, 48th Contraceptive Issues Effects of Aging. University Denmark, May 2017. Annual Meeting on Women’s among Young Women with of California San Diego, Cancers. National Harbour, Classen C, Drozd A, O’Meara Developmental Delay. Review Course in IVF. San MD, USA, March 2017. Y, Roelfsema L, Barbera L, 3rd International PAG/ Diego, CA, USA, July 2016. Carter J, Brotto L, Robinson Covens A. Non Radical COMEGO - 1st Regional Casper R. Hormone J, Ferguson S. GyneGals: Surgery for Early Stage Meeting NASPAG. Mexico City, Replacement Cycles for Oocyte An Online Support Group for Cervical Cancer. Division Mexico, September 2016. Donation and Deffered Transfer Women Who are Sexually of Gynaecologic Oncology. Allen L. Mullerian Duct – Is There an Ideal Regimen. Distressed Following Treatment Wayne State University, Henry Anomalies in Children and University of California San for Gynecologic Cancer. 18th Ford Cancer Centre. Detroit, Adolescents. 3rd International Diego, Review Course in IVF. International Psycho Oncology MI, USA, September 2017. PAG/COMEGO - 1st Regional San Diego, CA, USA, July 2016. Society World Congress. Covens A. International Meeting NASPAG. Mexico City, Dublin, Ireland, October 2016. Casper R. Cigarettes, Red Gynaecologic Cancer Society Mexico, September 2016. Wine and Reproduction. Colgan TJ. Gynecologic Perspective. Cervix Cancer Allen L. Functional Outcomes Fertility Society of Australia Cytology Correlation – Research Network. Mexico after Creation of a Neovagina Meeting. Perth, Australia, Perspectives from Ontario, City, Mexico, January 2017. with Laparoscopic Davydov September 2016. Canada and the Literature. Farine D. What Makes a in Patients with Vaginal International Academy Casper R. Ovarian Clinician Lose the Litigation Agenesis. 3rd International and European Society of Rejuvenation: Is it Possible? Over Birth Injury? 12th Asia PAG/COMEGO - 1st Regional Pathology Meeting. Cologne, Fertility Society of Australia Pacific Congress in Maternal Meeting NASPAG. Mexico City, Germany, September 2016. Meeting. Perth, Australia, Fetal Medicine. Penang, Mexico, September 2016. September 2016. Covens A. Early Stage Malaysia, October 2016. Bernardini MQ. Optimizing Cervical Cancer: Lessons Casper R. How can We Farine D. The Use of Initial Clearance of Advanced Learned from the Past, for Help the Patient with Progesterones of Cervical Ring Ovarian Cancer. International the Future. Department of Implantation Failure in FET Pessary in Preterm Prevention: Society of Gynecologic Obstetrics & Gynaecology, Cycles? Fertility Society of Questions Remained Oncology Shingo, Fujii Young Beaumont Hospital. Troy, Australia Meeting. Perth, Unanswered. 12th Asia Doctors Summit. Lisbon, MI, USA, September 2016. Australia, September 2016. Pacific Congress in Maternal Portugal, October 2016. Covens A. IGCS Global Fetal Medicine. Penang, Casper R. Clinical Application Caniggia I. Oxygen Sensing: Curriculum. GCIG. Lisbon, Malaysia, October 2016. of Oocyte Supplementation Novel Epigenetic Mechanisms. Portugal, October 2016. by Autologous Egg Precursor Farine D. Multiple Pregnancy: Latin American Society for Cell Mitochondrial Transfer. Covens A. Cervical Cancer: Optimal Mode and Timing of Maternal Fetal Interaction

92 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY INTERNATIONAL LECTURES

Delivery. 12th Asia Pacific Kingdom, April 2017. East-European Summit of (OC): The NEO trial. ASCO, Congress in Maternal/ Obstetrics and Gynecologists. Chicago, IL, USA, June 2017. Farine D. Sex and Pregnancy. Fetal Medicine. Penang, Moscow, Russia, May 2017. 1st World Congress of Kingdom JC. Preventing Malaysia, October 2016. Maternal Fetal Neonatal Farine D. Fetal Movement Preeclampsia: Beyond Farine D. Amniotic Fluid Medicine from Periconception Assessment – One of the Aspirin. 9th Philadelphia Embolism: Myths and to Early Infancy. London, Rarely Used Diagnostic Tests. Prenatal Diagnosis Misunderstandings. 12th Asia United Kingdom, April 2017. First East European Summit of Conference. Philadelphia, Pacific Congress in Maternal Obstetrics and Gynecologists. PA, USA, June 2017. Farine D. Corticosteroids Fetal Medicine. Penang, Moscow, Russia, May 2017. for Late Prematurity (34–37 Kingdom JC. PGIF: Beyond Malaysia, October 2016. weeks) – Do the New ACOG Ferguson S, Gien L, Giede Down Syndrome. 9th Farine D. FIGO Guidelines and SMFM Guidelines Make C, Samouëlian V, Steed H, Philadelphia Prenatal Diagnosis on PPH. 12th Asia Pacific Sense? Grand Rounds, Lenox Renkosinski B, Abitbol J, Conference, Philadelphia, Congress in Maternal Hill Hospital. New York Warkus T, Le T, Martin V, PA, USA, June 2017. Fetal Medicine. Penang, City, NY, USA, May 2017. Bernardini MQ. GOC2: A Kingdom JC. Management Malaysia, October 2016. Multi-centre Prospective Trial Farine D. Fetal Well-Being of Invasive Placenta. 9th Comparing Open, Laparoscopic Farine D. Electronic Fetal Monitoring from Counting Philadelphia Prenatal Diagnosis and Robotic Surgical Outcomes Monitoring vs. Auscultation: Fetal Movements to Doppler Conference, Philadelphia, in Women with Endometrial Which One Should be Used? Measurements. Advances in PA, USA, June 2017. Cancer: Part A: Peri-operative 24th World Congress on Perinatology and Gynecology Outcomes. Society of Kingdom JC. The Placenta Controversies in Obstetrics, – Ian Donald International Gynecologic Oncology, 48th and IUGR. 9th Philadelphia Gynaecology & Infertility. School of Ultrasound in Annual Meeting on Women’s Prenatal Diagnosis Amsterdam, The Netherlands, Obstetrics and Gynecology. Cancers. National Harbor, Conference, Philadelphia, November 2016. Warsaw, Poland, May 2017. Maryland, USA, March 2017. PA, USA, June 2017. Farine D. Fetal Movement Farine D. The Use and Misuse Hare C, Torbitt L, Ferguson Kingdom JC. Screening, Count – The Neglected of Guidelines. Advances in S, Hart T. The Role of Illness Diagnosis and Management Antenatal Test. 1st World Perinatology and Gynecology Perceptions in Cancer-related of Placental Dysfunction. Congress of Maternal Fetal – Ian Donald International Fatigue Outcomes in Ovarian Department of Obstetrics Neonatal Medicine from School of Ultrasound in Cancer Patients. 38th Annual & Gynaecology, University Periconception to Early Obstetrics and Gynecology. Meeting of the Society of of Colorado, Clinical Grand Infancy. London, United Warsaw, Poland, May 2017. Behavioral Medicine. San Rounds. Denver, CO, Kingdom, April 2017. Farine D. Corticosteroids Diego, CA, USA, March 2017. USA, February 2017. Farine D. A Step-by-Step for Late Prematurity (24–37 Kanjanapan Y, Lheureux S, Kingdom JC. Can Heparin Approach to Massive weeks) – Do the New ACOG May T, Wilson M, Bernardini Prevent Severe Pre-eclampsia? Transfusion: When, What and and SMFM Make Sense? First MQ, Shaw P, Vergote I, Brenton Reproductive Sciences Seminar, How? 1st World Congress East-European Summit of J, Provencher D, McNeish University of Colorado, Denver, of Maternal Fetal Neonatal Obstetrics and Gynecologists. I, Ghatage P, Ledermann CO, USA, February 2017. Medicine from Periconception Moscow, Russia, May 2017. J, Colombo N, Gourley C, to Early Infancy. London, Kingdom JC. Can LMWH Farine D. PPH - The New Weberpals J, Ramsahai J, United Kingdom, April 2017. Heparin Prevent or Significantly FIGO Guidelines. First Ricker N, Accardi S, Wang. Reduce the Severity of Farine D. The Effect of RCT’s East-European Summit of Oza APhase II Open-Label Preeclampsia-IUGR? Maternal on Clinical Guidelines. 1st Obstetrics and Gynecologists. Randomized Multi-Centre Study Hemodynamics Conference. World Congress of Maternal Moscow, Russia, May 2017. of Neoadjuvant Olaparib in Milan, Italy, January 2017. Fetal Neonatal Medicine Patients (pts) with Platinum Farine D. How to Deliver the from Periconception to Early Sensitive (PS) Relapsed High Lee SK. Improving Qualiity Extremely Obese Patient. First Infancy. London, United Grade Serous Ovarian Cancer in the NICU. REASON

ANNUAL REPORT 2016/17 93

Conference. Coventry, United for preterm birth research. Librach CL. Extracellular Society of Andrology, Kingdom, July 2016. GCAPR. Washington, DC, Vesicles Small RNA in Annual Trainee-Directed USA, March 2017. Human Reproductive Fluids: Mini-Symposium, invited Lee SK. Family as Care- Regulators of Fertility? The panel speaker, Miami, FL, givers in the NICU. REASON Lee SK. Family Integrated Annual International Exchange USA, April 23, 2017 Conference. Coventry, United Care in the NICU. Disability Course in Developmental Kingdom, July 2016. Conference. Seattle, Murji A. Fibroids and Uterine and Perinatal Biology: A WA, USA May 2017 Bleeding: Unlocking the Lee SK. Family Integrated Care. Joint Course between the Issues. 3rd Congress of the Perinatal Rounds, Birmingham Li T, Danesh A, Van de Laar University of Toronto and the Society of Endometriosis Women’s Hospital. Birmingham, E, Clarke B, Tone A, Gallinger Karolinska Institute. Stockholm, and Uterine Disorders. United Kingdom, July 2016. S, Ferguson S, Pugh T. An Sweden, August 2016. Singapore, April 2017. Integrative Panel to Accurately Lee SK. Family Integrated Librach CL. The umbilical Detect Lynch Syndrome and Nagy A. Stem Cells “R” Care. Perinatal Rounds, cord MSCs for fertility Somatic Mismatch Repair Us. Jackson Lab Board Leeds Infirmary. Leeds, preservation and regenerative Deficiency. Annual Clinical of Scientific Counselors United Kingdom, July 2016. therapy. Society for the Genetics Meeting. Phoenix, Seminar. Bar Harbor, Maine, Study of Reproduction. San AZ, USA, March 2017. USA, August 2016. Lee SK. Family as Care- Diego, CA, USA, July 2016. givers in the NICU. Qilu Librach CL. PGS Testing and Nagy A. Addressing Cell Forum of Children’s Luketic L, Shirreff L, Kives Embryo Selection. Families Therapy Safety with Genome Medical Development. S, Solnik J, Leyland N, Liu through Surrogacy. London, Editing. Development, Aging, Jinan, PRC, July 2016. G, El Sugy R, Murji A. Does England, March 2017. Regeneration and Metabolism, Ulipristal Acetate Objectively Lee SK. Family Integrated Care. Spetses Summer School. Librach CL. PGS Testing and Affect Surgical experience at Neonatal Transition Summit. Spetses, Greece, August 2016. Embryo Selection. Families laparoscopy myomectomy. Shenzhen, PRC, October 2016. through Surrogacy. Dublin, 45th American Association of Nagy A. Pluripotency in Lee SK. Reflections on Early Ireland, March 2017. Gynecologic Laparoscopists, the Artificial Cell Space. Childhood Development Global Congress on Minimally Development, Aging, Librach CL. Understanding Forum. Canadian Institute Invasive Surgery. Orlando, Regeneration and Metabolism, IVF, Embryo Testing and for Advanced Research FL, USA, November 2016. Sptses Summer School. Transfer Decisions. Families Forum on Early Childhood Sptses, Greece, August 2016. through Surrogacy. London, May T, Bernardini MQ. Clinical Development. London, United England, March 2017. Behaviour of Low Grade Serous Nagy A. Stem Cells, Kingdom, November 2016. Ovarian Carcinoma – An Pluripotency and Librach CL. Understanding Lee SK. Evidence, Research Analysis of 714 Patients from Reprogramming. Frontiers in IVF, Embryo Testing and and the Canadian Healthcare the Ovarian Cancer Association Stem Cells and Regeneration Transfer Decisions. Families System. Ireland Health Consortium. Society of Advanced Training Course, through Surrogacy. Dublin, Research Board Conference. Gynecologic Oncology, 48th Marine Biological Laboratory Ireland, March 2017. Dublin, Ireland, November 2016. Annual Meeting on Women’s (MBL). Woods Hole, MA, Librach CL. Methods and Cancers. National Harbor, USA, September 2016. Lee SK. Family integrated Tools to Assess Embryo MD, USA. March 2017. care in the NICU. Hot Nagy A. Stem Cells: Road to the Quality in the IVF Clinic. The Topics. Washington, DC, Melamed N. Timing of Delivery Clinic (in Hungarian) Ossejtek: Annual International Exchange USA, December 2016. in Women with Gestational út a klinikára. Hungarian Course in Developmental Diabetes. 9th International Academy of Science, Hungarian and Perinatal Biology: A Lee SK. Canada’s investment Symposium on Diabetes, Society Meeting. Budapest, Joint Course between the in Preterm Birth Research. Hypertension, Metabolic Hungary, September 2016. GCAPR. Washington, DC, University of Toronto and the Syndrome and Pregnancy. USA, March 2017. Karolinska Institute. Stockholm, Barcelona, Spain, March 2017. Nagy A. Multiple Ways of Sweden, August 2016. Using Pluripotency for the Lee SK. Data harmonization Moskovtsev SI. American

94 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY International Lectures

Treatment of Diabetes. 3rd of Toledo College of Medicine Pairaudeau N. Difficult C Private Hospital, Mater Banting and Best Diabetes and Life Sciences. Toledo, Sections. Norman Bethune Hospital, Prince of Wales Centre Meeting. Boston, OH, USA, March 2017. China Medical Tour. Private Hospital, Royal MA, USA, November 2016. Zhangzhou City Hospital, Nagy A. Designer Cells: Hospital for Women. Sydney, Fujian, China, May 2017. Nagy A. Combining Gene “Fail-safe” Cells for Therapies. Australia, May 2017. and Cell Therapies to Treat Hungarian Molecular Pairaudeau N. MIS Shynlova O. Maternal Degenerative Diseases: Life Sciences 2017. Eger, Complications. Norman Peripheral Blood Leukocytes Overcoming the Obstacles. Hungary, March 2017. Bethune China Medical Tour. as Biomarkers of Preterm The Eye Center of The Second Zhangzhou City Hospital, Nulman I, Barrera M, Birth. 64th Annual Meeting of Affiliated Hospital of Zhejiang Fujian, China, May 2017. Maxwell C, Nguyen G. The the Society for Reproductive University. Zhejiang, Wenzhou, Child Neurodevelopment Pairaudeau N. Norman Investigation. Orlando, China, November 2016. Following In-Utero Exposure Bethune Eulogy. Norman FL, USA, March 2017. Nagy A. Pluripotency in the to Pharmacotherapy for Bethune China Medical Tour. Solnik J. Masses for the Artifical Cell Space: Broadening Inflammatory Bowel Disease. Zhangzhou City Hospital, Masses. Medstar, Grand the Therapeutic Potential of 30th Annual Education Fujian, China, May 2017. Rounds, George Washington Stem Cells. Center of Stem Cell Meeting for Organization Rogers I. Umbilical Cord Blood University. Washington, and Regenerative Medicine. of Teratology Information and Tissue Stem Cells for Cell DC, USA, March 2017. Zhejiang University. Zhejiang, Specialists Members and Therapy. Knox Private Hospital China, November 2016. Mother to Baby Affiliates. Ternamian A. Safe and Mitcham Private Hospital. Denver, USA, June 2017. Laparoscopic Peritoneal Entry. Nagy A. Toward Developing Melbourne, Australia, May 2017. University of Alexandria, a Partnership Network in Pairaudeau N. Cultural Rogers I. Umbilical Cord Blood Hands on Suturing and Regenerative Medicine. Differences in Implementing and Tissue Stem Cells for Cell Hysteroscopy Course. BioMelbourne Network Doctor Patient Relationships. Therapy. The Wesley Hospital, Alexandria, Egypt, May 2017. Breakfast. Melbourne, Society of Laparoendoscopic Northwest Private Hospital, Australia, December 2016. Surgeons Conference. Boston, Ternamian A. Fundamentals Sunnybank Private Hospital, MA, USA, August 2016. of Total Laparoscopic Nagy A. The Successful Pindara Private Hospital, The Hysterectomy. University of Model of the Centre for Pairaudeau N. Difficult Mater Mothers Private Hospital. Alexandria, Hands on Suturing Commercialization of C Sections. Norman Brisbane, Australia, May 2017. and Hysteroscopy Course. Regenerative Medicine: Bethune China Medical Rogers I. Mesenchymal Alexandria, Egypt, May 2017. Fostering a Global Ecosystem to Tour. Lianyungang Hemijia Stem Cells from UCT to treat Accelerate the Development of O & G Hospital. Jiangsu, Ternamian A. Risk Diabetic Wounds. Cell Care. Stem Cell Therapies. Consulate China, May 2017. Management in Operative Melbourne, Australia, May 2017. General of Canada. Sydney, Hysteroscopy. University of Pairaudeau N. MIS Australia, December 2016. Rogers I. Umbilical Cord Alexandria, Hands on Suturing Complications. Norman Blood and Tissue Stem Cells and Hysteroscopy Course. Nagy A. A Fail-safe Solution Bethune China Medical for Cell Therapy. Joondalup Alexandria, Egypt, May 2017. for Cell-based Therapies. The Tour. Lianyungang Hemijia Private Hospital. Perth, Croucher Foundation Advanced O & G Hospital. Jiangsu, Ternamian A. Urinary Australia, May 2017. Study Institute on Stem Cells: China, May 2017. Complications in Operative Biology and Applications, Rogers I. New Advances in Endoscopy. University of Pairaudeau N. Norman Hong Kong University. Hong Umbilical Cord Blood Therapies. Alexandria, Hands on Suturing Bethune Eulogy. Norman Kong, January 2017. Ashford Private Hospital, and Hysteroscopy Course. Bethune China Medical Adelaide, Australia, May 2017. Alexandria, Egypt, May 2017. Nagy A. Addressing Cell Tour. Lianyungang Hemijia Therapy Safety with Genome O & G Hospital. Jiangsu, Rogers I. New Advances Ternamian A. Hands on Editing. Council of Biomedical China, May 2017. in Umbilical Cord Blood Suturing and Hysteroscopy Graduate Students, University Therapies. North Shore Course. University of Kiel,

ANNUAL REPORT 2016/17 95 International Lectures

Department of Obstetrics & Ternamian A. How to Write Reproductive Care for People Gynaecology, Gynecological an Abstract for Publication. Living with HIV and Those at Endoscopic and Reproductive Endo Dubai Regional Risk. HIVE and UCSF Grand Medicine Course. Kiel, Conference of the Middle Rounds. UCSF at Zuckerberg Germany, May 2017. East Society of Gynecological San Francisco General Hospital Endoscopy. Dubai, United and Trauma Center. San Ternamian A. Peritoneal Arab Emirates, March 2017. Francisco, CA, USA, May 2017. Entry and Patient Safety; the Canadian SOGC Clinical Van Mieghem T. Maternal Yudin M. Zika A to Z: For the Practice Guideline. University Complications of Fetal Parent and the Parent to Be. of Kiel, Department of Surgery. 20th International The North American Society Obstetrics & Gynaecology, Conference on Prenatal for Pediatric and Adolescent Gynecological Endoscopic and Diagnosis and Therapy. Gynecology, 31st Annual Reproductive Medicine Course. Berlin, Germany, July 2016. Clinical and Research Meeting. Kiel, Germany, May 2017. Chicago, IL, USA, April 2017. Wais M, Kives S, Lee S, Liu Ternamian A. Risk G, Pham A, Murji A. Surgical Yudin M. Bacterial Vaginosis Management in Endoscopic Experience with Ulipristal and Pregnancy: Risks and Surgery. University of Kiel, Acetate or Gonadotrophin Complications. International Department of Obstetrics & Releasing Agonists for Uterine Advisory Board Meeting Gynaecology, Gynecological Fibroids. 45th American on Impact of and New Endoscopic and Reproductive Association of Gynecologic Therapies for Bacterial Medicine Course. Kiel, Laparoscopists, Global Vaginosis. San Francisco, Germany, May 2017. Congress on Minimally CA, USA, January 2017. Invasive Surgery. Orlando, Ternamian A. Total FL, USA, November 2016. Laparoscopic Hysterectomy; Global Perspective. University Yudin M. Perspectives on of Kiel, Department of the Care of the HIV-positive Obstetrics & Gynaecology, Pregnant Woman. HIVE Gynecological Endoscopic and San Francisco. University Reproductive Medicine Course. of California at San Kiel, Germany, May 2017. Francisco. San Francisco, CA, USA, October 2017. Ternamian A. Informed Consent in Gynecological Yudin M. HIV, Fatherhood, and Endoscopy. Endo Dubai Fertility/Universities without Regional Conference of Walls and the Ontario HIV the Middle East Society of Treatment Network. June 2017. Gynecological Endoscopy. Yudin M. Zika Virus and the Dubai, United Arab Placenta: Implications for Emirates, March 2017. Pregnancy Care Provider. Ternamian A. How to Review Israeli Society of Maternal Fetal a Scientific Paper. Endo Medicine and Israel Society Dubai Regional Conference for Placenta Research. Tel of the Middle East Society Hashomer Hospital, Sheba of Gynecological Endoscopy. Medical Center. Ramat Dubai, United Arab Gan, Israel, June 2017. Emirates, March 2017. Yudin M. Trauma-informed

96 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY NATIONAL LECTURES

Alayed N, Okun N, Chong Kingdom JC. Can Heparin Librach CL. Should Genetic May T. If Complete K, Noor A, Chitayat D, Prevent Severe Preeclampsia? Carrier Testing be Offered Cytoreduction to Microscopic Kolomietz E. Chromosomal 4th Annual Canadian to all Couples Getting Residual isn’t Feasible, Microarray as a First Tier Test National Perinatal Research Fertility Care? Canadian Should Primary Cytoreduction Following Diagnostic Prenatal Meeting. Montebello, QC, Fertility and Andrology be Aborted? The Society Procedures, The Toronto Mount Canada, February 2017. Society Meeting. Toronto, ON, of Obstetricians and Sinai Hospital Experience. Canada, September 2016. Gynaecologists of Canada, Kingdom JC. The Surgical Canadian National Perinatal 73rd Annual Clinical and Approach to the Invasive Librach CL. Stem Cell Banking. Research Meeting. Banff, AB, Scientific Conference. Ottawa, Placenta: Planning for Toronto East General Hospital – Canada, February 2016. ON, Canada, June 2017. Better Outcomes. The Interhospital Rounds. Toronto, Berger H. New SOGC Society of Obstetricians and ON, Canada, January 2017. May T. Robotic Radical Guidelines on Diabetes in Gynaecologists of Canada, Trachelectomy. From Routine Liu K, Cohen S. Reproductive Pregnancy – The Unanswered 73rd Annual Clinical and to Advanced Minimally Tourism: Egg Donation Questions. West Central Scientific Conference. Ottawa, Invasive Surgery. Hands- and Surrogacy. Society CME SOGC. Banff, AB, ON, Canada, June 2017. On Surgical Workshop. The of Obstetricians and Canada, March 2017. Society of Obstetricians and Ladhani N. Management Gynecologists of Canada Gynaecologists of Canada, Berger H. NIPT: What’s New. of Pregnancy Subsequent Annual Clinical and Scientific 73rd Annual Clinical and West Central CME 2017 SOGC. to Stillbirth. The Society Conference. Ottawa, ON, Scientific Conference. Ottawa, Banff, AB, Canada, March 2017. of Obstetricians and Canada, June 2017. ON, Canada, June 2017. Gynaecologists of Canada, Chitayat D. Fetal Akinesia. Liu K, Barankin B. Debunking 73rd Annual Clinical and May T. Complete Surgical Fetoscopy. Vancouver, BC, the Facts and Myths Scientific Conference. Ottawa, Resection and Impact on Canada, September 2016. Surrounding Hormonal ON, Canada, June 2017. Survival in Newly Diagnosed Acne Therapy. Dermatology Ferguson S. Update on Advanced Ovarian Cancer. Laframboise S. Diagnosis and Update. Montreal, QC, Universal Screening for 1st Annual MyGoals Meeting- Work-up of Suspicious Ovarian Canada, November 2016. Lynch Syndrome in Newly Multidisciplinary Gynecologic Neoplasms. 1st Annual MyGoals Diagnosed Ovarian Cancer Luketic L, Shirreff L, Kives Oncology Annual Lecture Series. Meeting – Multidisciplinary in Ontario. Hereditary GI S, Solnik J, Leyland N, Liu Toronto, ON, Canada, May 2017. Gynecologic Oncology Annual Cancer Symposium. Toronto, G, El Sugy R, Murji A. Does Lecture Series. Toronto, Maxwell C. Multidisciplinary ON, Canada, May 2017. Ulipristal Acetate Objectively ON, Canada, May 2017. Approach to Obstetric Affect Surgical Experience at Jacob G , Vilos A, Vilos G, Patient with Neurological Laframboise S. Management Laparoscopy Myomectomy. Abu-Rafea B, Ternamian A. Disease: From Assessment to of Newly Diagnosed Ovarian 3rd Annual Clinical and Laparoscopic Bowel Injuries: Management of Complications. Cancer. 1st Annual MyGoals Scientific Conference. Ottawa, Lessons from 23 Litigated Canadian Anaesthesia Society Meeting – Multidisciplinary ON, Canada, June 2017. Gynecologic Cases in Canada. Meeting. Niagara Falls, Gynecologic Oncology Annual 2nd Annual Conference of May T, Lheureux S, Bernardini ON. Canada, June 2017. Lecture Series. Toronto, ON, the Canadian Society for the MQ, Jiang H, Tone A. Canada, March 2017. Moskovtsev SI. Laboratory Advancement of Gynecologic Identification of Survival Evaluation of Male Fertility. Excellence. Montreal, QC, Lee SK. Parents as Caregivers Altering Parameters in McGill University. Montreal, Canada, September 2017. in the NICU. CME Activity at Low Grade Serous Ovarian QC, Canada, March 2017. University of Calgary. Calgary, Carcinoma – An Analysis of Jumah NA. Indigenous AB, Canada, March 2017. 714 Patients from the Ovarian Murji A. Fibroids and Fertility – Women’s Health Research Cancer Association Consortium. When to Operate and When Not in Northwestern Ontario. Lee SK. Family Integrated The Society of Gynecologic to. The Society of Obstetricians Parliamentary Health Care in the NICU. Calgary Oncology of Canada 38th and Gynaecologists of Canada, Research Caucus. Ottawa, Update. Calgary, AB, Annual General Meeting. 73rd Annual Clinical and ON, Canada, June 2017. Canada, March 2017. Ottawa, ON, Canada, June 2017. Scientific Conference. Ottawa,

ANNUAL REPORT 2016/17 97 National Lectures

ON, Canada, June 2017. Umbilical Cord Blood and Ternamian A. Medical Annual Clinical Meeting, Tissue for Regenerative Management of Uterine Society of Obstetricians and Murji A. Fibroids. The Medicine. Academic Half Fibroids. Medical Advisory Gynecologists of Canada. Society of Obstetricians and Day, Foothills Women’s Board Meeting – AbbVie. Ottawa, ON, Canada, June 2017. Gynaecologists of Canada, Health Centre. Calgary, AB, Montreal, QC, Canada, 73rd Annual Clinical and Yudin M. Zika Virus Canada, November 2016. February 2017. Scientific Conference. Ottawa, in Pregnancy. 72nd ON, Canada, June 2017. Rogers I. A Primer on Stem Thistle PJ. How to Prepare Annual Clinical Meeting, Cell Biology: Personalized for Short Term Volunteer Society of Obstetricians Murji A. Beyond a Simple Medicine and Diabetes. 19th Work Abroad: The Pearls and and Gynecologists of Cyst – Approach to Ovarian Annual Canadian Diabetes Pitfalls. The Society of Rural Canada. Vancouver, BC, Endometrioma Surgery. Association Meeting. Ottawa, Physicians of Canada’s 25th Canada, June 2016. 13th World Congress on ON, Canada, October 2016. Annual Rural and Remote Endometriosis. Vancouver, Medicine Course. Calgary, BC, Canada, May 2017. Rogers I. Cord Blood Derived AB, Canada, April 2017. Cells for Tissue and Organ Murji A. MIS Gynecology Regeneration. Conference: Thistle PJ. Providing Medical Principles – Basic Anatomy Graft versus Host Disease Care in Under-resourced for Laparoscopy. University Symposium/Canadian Blood Remote Environments. The of Toronto, Department of Services/Hema-Quebec Society of Rural Physicians Obstetrics & Gynaecology, Symposium. Ottawa, ON, of Canada’s 25th Annual Annual uOttawa MIS Canada, September 2016. Rural and Remote Medicine Gynecology Day. Ottawa, Course. Calgary, AB, ON, Canada, May 2017. Rogers I. Utilisation des Canada, April 2017. Cellules du Sang et du Tissue Murji A. MIS Gynecology de Cordon Ombilical dans le Vilos G, Vilos A, Jacob G, Abu- Principles – Complications Cadre des Thérapies Évoluées Rafea B, Ternamian A. Safe You Don’t Want to Have. de Cellules Souches. Hôpital Intra-peritoneal Placement for University of Toronto, de la Cité-de-la-Santé. Laval, Laparoscopic Entry – Video Department of Obstetrics & QC, Canada, September 2016. Presentation. 2nd Annual Gynaecology, Annual uOttawa Conference of the Canadian Minimally Invasive Surgery Selk A. LSIL. Society of Society for the Advancement Gynecology Day. Ottawa, Obstetrics and Gynaecology, of Gynecologic Excellence ON, Canada, May 2017. 73rd Annual Clinical and (CanSAGE2). Montreal, QC, Scientific Meeting. Ottawa, Murji A. Creating Canada, September 2017. ON, Canada, June 2017. Collaborations in Yudin M. Update on Zika Virus. Research – Reflections Selk A. Where to Biopsy. Society Controversies in Obstetrics, from the Start of a Career. of Obstetrics and Gynaecology, Gynecology and Infertility. 24th University of Saskatchewan, 73rd Annual Clinical and World Congress. Amsterdam. Department of Obstetrics & Scientific Meeting. Ottawa, Netherlands, November 2016. Gynaecology. Saskatchewan, ON, Canada, June 2017. Canada, March 2017. Yudin M. Vaccination in Shynlova O. Recent Advances Pregnancy. 73rd Annual Nagy A. A Fail-safe Solution in Regenerative Medicine Clinical Meeting, Society for Cell-based Therapies. in Pelvic Floor Disorders. of Obstetricians and Till and McCulloch Annual International Urogynecological Gynecologists of Canada. General Meeting. Whistler, Association 42nd Annual Ottawa, ON, Canada, June 2017. BC, Canada, October 2016. Meeting, Basic Science Roundtable. Vancouver, Yudin M. STI update – Drug Rogers I. Banking BC, Canada, June 2017. Resistant Gonorrhea. 73rd

98 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY LOCAL LECTURES

Allen L. Abnormal Uterine Interhospital Rounds, St. Cancer Centre. Toronto, ON, Resident Orientation Day, Bleeding Revisited: PALM Michael’s Hospital. Toronto, Canada, October 2017. University of Toronto, COEIN and the Adolescent ON, Canada, April 2017. Department of Obstetrics Bernardini MQ. Optimizing Pediatric and Adolescent & Gynaecology. Toronto, Berger H. The Effect of Initial Clearance in Gynecology Review Day. ON, Canada, June 2016. Antenatal Corticosteroids Advanced Ovarian Cancer. University of Toronto, on the Fetal Thymus. Grand Humber River Hospital, Caniggia I. Endocrinology Department of Obstetrics & Rounds, The Hospital for Department of Obstetrics of Early Pregnancy: Corpus Gynaecology. Toronto, ON, Sick Children. Toronto, ON, and Gynecology. Toronto, Luteum to Placental Shift. Canada, January 2017. Canada, October 2016. ON, Canada, October 2017. Gynaecologic Reproductive Allen L. Abnormal Uterine Endocrinology and Infertility Berger H. NIPT and Second Brown TJ. Research Opus. Bleeding Revisited: PALM Academic Half Day, University Trimester Ultrasound – Resident Orientation, University COEIN and the Adolescents. of Toronto. Toronto, ON, Companions or Competitors? of Toronto, Department of Grand Rounds, Michael Canada, January 2017. 62nd Annual Meeting, Obstetrics and Gynecology. Garron Hospital, Department Canadian Fertility and Toronto, ON, Canada, June 2017. Covens A. Possible Cervical of Pediatrics. Toronto, ON, Andrology Society. Toronto, ON, Cancer. Optimizing Referrals Canada, February 2017. Brown TJ. Mentoring and Canada, September 2016. and Workup of Gynaecologic Supervising Research Trainees: Assal A, Jones C. A Study Malignancies. University Berger H. New SOGC How to Foster a Working on the Impact of the of Toronto, Division of Guidelines on Diabetes in Knowledge of Research. Faculty Ontario Fertility Program Gynecologic Oncology. Toronto, Pregnancy – The Unanswered Development Day, University on Duplicate Consultations. ON, Canada, March 2017. Questions. Ontario Continuing of Toronto, Department of The Gatekeeper’s Dilemma Medical Education 2016, Obstetrics & Gynaecology. Covens A. Surgical Sentinel 2017, Canadian Fertility and Society of Obstetricians Department Toronto, ON, Lymph Node Mapping for Andrology Society. Toronto, and Gynecologists of Canada, November 2016. Endometrial Cancer. Inaugural ON, Canada, June 2017. Canada. Toronto, ON, MyGOALS: Multidisciplinary Brown TJ. The Trials and Barrett J, Okun N, Czikk M, Canada, December 2016. Gynecologic Oncology Annual Tribulations of Authorship. Berger H. The Southern Ontario Lecture Series. University Berger H. NIPT: What’s Faculty Development Day, Obstetric Network: Past Present of Toronto. Toronto, ON, New. Ontario Continuing University of Toronto, and Future. Interhospital Canada, March 2017. Medical Education 2016, Department of Obstetrics & Rounds, University of Toronto, Society of Obstetricians Gynaecology. Department Cusimano M, Ferguson S. Department of Obstetrics and Gynecologists of Toronto, ON, Canada, Prospective Validation of & Gynaecology. Toronto, Canada. Toronto, ON, November 2016. Sentinel Lymph Node Biopsy ON, Canada, April 2017. Canada, December 2016. with Indocyanine Green Brown TJ. Human Research Berger H. Obstetrical Flourescence Imagine in Bernardini MQ. GOC-2: Ethics. Graduate Student Ultrasound. 2nd Annual High-grade Endometrial Outcomes of the Canadian Orientation, University of Sonography Conference. Cancer. 34th Annual Research Prospective Surgical Trial Toronto, Department of Toronto, ON, Canada, Day, University of Toronto for Endometrial Cancer Physiology. Toronto, ON, November 2017. Department of Obstetrics Management: Where Does the Canada, September 2016. & Gynaecology. Toronto, Berger H. Diabetes in Robot Fit in? Grand Rounds, Brown TJ. Grant Writing, ON, Canada, April 2017. Pregnancy. Grand River Sinai Health System. Toronto, Research Process and Hospital Perinatal Lecture ON, Canada, February 2017. Derzko C. When Ovaries Retire Pearls. Fellows Research Series. Kitchener, ON, Too Soon: The Consequences Bernardini MQ. Surgical Course, University of Toronto, Canada, October 2017. and Management of Management of Epithelial Department of Obstetrics & Premature Ovarian Failure. Berger H. The Southern Ovarian Cancer. Astra Gynaecology. Toronto, ON, Endocrinology Rounds, St. Ontario Obstetric Network: Zeneca Preceptorship Canada, September 2016. Michaels Hospital. Toronto, Past, Present and Future. Lectures, Princess Margaret Brown TJ. Research Opus. ON, Canada, November 2017.

ANNUAL REPORT 2016/17 99

Derzko C. Menopause 2017 – Research Course, Mount Farine D. Medico-legal and in Pregnancy. Refresher in An Update. Family Medicine, Sinai Hospital. Toronto, ON, Obstetrical Ultrasound. Primary Maternity Care. Mount Academic Half Day. Toronto, Canada, September 2016. 20th Annual Obstetrical Sinai Hospital, Continuing ON, Canada, May 2017. Ultrasound Course. Toronto, Medical Education. Toronto, D’Souza R. Decision Analysis. ON, Canada, February 2017. ON, Canada, May 2017. Derzko C. The Role of Health Research Course, Reproductive Hormone Therapy Mount Sinai Hospital, Farine D. Sex in Pregnancy. Jones C. IVF 101 – The Ontario in Bone and Muscle Health. Department of Obstetrics & Medical Complications of Aspect. 25th Annual New Canadian Musculoskeletal Gynaecology. Toronto, ON, Pregnancy Rounds, Mount Developments in Prenatal Conference. Toronto, ON, Canada, September 2016. Sinai Hospital. Toronto, ON, Diagnosis and Medical Canada, October 2016. Canada, March 2017. Genetics. Mount Sinai Hospital, D’Souza R. Induction of Labour Continuing Medical Education. D’Souza R. Choosing the for Low-risk Women – Is 39 the Ferguson S. Sentinel Lymph Toronto, ON, Canada, May 2017. Optimal Blood-thinner New 41? St. Joseph’s Health Node Mapping in Gynecologic for Pregnant Women with Care Centre Rounds. Toronto, Cancer. Grand Rounds, Jones C. Hatch you later! – Mechanical Heart Valves – A ON, Canada, May 2017. University Health Network, Taking control of Your Fertility. Novel Three-step Approach. Department of Surgery. Toronto, Lecture on Social Egg Freezing. D’Souza R. Induction of Labour Graduate Speakers Series: ON, Canada, September 2016. Women’s Health Event, Mount for Low-risk Women – Is 39 the Women’s and Children’s Health, Sinai Hospital. Toronto, New 41? Credit Valley/ Trillium Freire-Lizama T. ICP. Grand University of Toronto. Toronto, ON, Canada, May 2017. Group Grounds. Mississauga, Rounds, Credit Valley Hospital. ON, Canada, May 2017. ON, Canada, April 2017. Toronto, ON, Canada, June 2017. Jones C. LGBTQ Family D’Souza R. Hypertensive Building. Clinical Evaluation Ermini L, Post M, Caniggia Freire-Lizama T. Select Disorders in Pregnancy. and Treatment of Infertility. I. A Single Sphingomyelin Topics in Maternal-Fetal High Risk Course for Labour Mount Sinai Hospital, Species Promotes Exosomal Medicine. Toronto, ON, and Delivery, Mount Sinai Continuing Medical Release of Endoglin into Canada, April 2017. Hospital. Toronto, ON, Education. Toronto, ON, the Maternal Circulation in Canada, April 2017. Freire-Lizama T. OB Review: Canada, September 2016. Preeclampsia. 34th Annual PET, Prematurity, IGUR, D’Souza R. Induction for Research Day, University Jones C, Chan C. Be it Resolved LBW, OB Complications. Macrosomia: When to Deliver. of Toronto Department of that Social Egg Freezing Should University of Toronto. Toronto, 15th Annual Refresher in Obstetrics & Gynaecology. be Offered to all Patients and ON, Canada, April 2017. Primary Maternity Care, is a way to Provide Women Farine D. PPH – The New University of Toronto. Toronto, Gien LT. Optimizing Reproductive Autonomy. Mount FIGO Guidelines. 13th Annual ON, Canada, May 2017. Workup and Referral for Sinai Hospital, Continuing Obstetrical Malpractice: A Postmenopausal Bleeding Medical Education. Toronto, D’Souza R. Induction of Labour Survival Guide for 2017, Mount and Uterine Masses. Cancer ON, Canada, September 2016. for Low-risk Women – Is 39 Sinai Hospital. Toronto, ON, Care Ontario Communities the New 41? Humber Valley Canada, January 2017. Jumah NA. Women’s of Practice. Toronto, ON, Regional Hospital Rounds. Reproductive Health Research Farine D. Steroids – Late Canada, March 2017. York, ON, Canada, May 2017. at the Thunder Bay Regional Preterm Birth. 13th Annual Gotz T, Jones C. Year One of Health Sciences Centre. D’Souza R. Induction of Labour Obstetrical Malpractice: A the Ontario Fertility Program: PSI Foundation Annual for Low-risk Women – Is 39 Survival Guide for 2017, Mount The Patient Experience – A General Meeting. Toronto, the New 41? Mount Sinai Sinai Hospital. Toronto, ON, Survey of 250 Patients in the ON, Canada, April 2017. Hospital Rounds. Toronto, ON, Canada, January 2017. GTA. The Gatekeeper’s Dilemma Canada, September 2016. Jumah NA. Cervical Screening Farine D. Risk Management 2017, Canadian Fertility and and Follow Up after Colposcopy. D’Souza R. Cohort Studies and Malpractice. Maternal Andrology Society. Toronto, COPE Conference. Thunder and Cross Sectional Studies. Fetal Medicine Academic ON, Canada, June 2017. Bay, ON, Canada, May 2017. Department of Obstetrics Half Day. Toronto, ON, Jones C, Chan C. Travel & Gynaecology Health Canada, February 2017. Jumah NA. Motherhood under

100 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Local Lectures

the Microscope. Thunder Bay Maternity Care. Toronto, Growth Meeting. Symposium Lee SK. Networks for Regional Health Sciences ON, Canada, May 2017. Six: Interventions to Improve Research and Quality Centre Psychiatry Retreat. IUGR Outcomes. Toronto, ON, Improvement. CAGS. Toronto, Kingdom JC. Doppler Live June 2017, Thunder Bay, ON. Canada, November 2016. ON, Canada, February 2017. Scan. 20th Annual Obstetric Keunen J. Differential Ultrasound: Setting the Kingdom JC, Morgen E. Inter- Liu K. Work-up for the Infertile Diagnosis and Investigation. Standard for 2017. Toronto, Active Case Studies: How to Couple. Ontario College of Symposium Two: Implications ON, Canada, February 2017. Interpret Pathology and Counsel Family Physicians Annual of IUGR. 5th International Fetal Post-Partum. Fetal Growth Conference. Toronto, ON, Kingdom JC. Placenta Function Growth Conference. Toronto, 2016. Symposium Three: Canada, November 2016. Evaluation. 20th Annual ON, Canada, November 2016. Placental Basis IUGR. Toronto, Obstetric Ultrasound: Setting Maxwell C. Introduction to ON, Canada, November 2016. Keunen J. Review of all the the Standard for 2017. Toronto, the MFM Fellowship Program. Imagine Protocols Discussed ON, Canada, February 2017. Laframboise S. Diagnosis Maternal-Fetal Medicine Career This Conference. 20th Annual and work-up of suspicious Night, Department of Obstetrics Kingdom JC. Invasive Obstetric Ultrasound: Setting ovarian neoplasms. Inaugural & Gynaecology. Toronto, ON, Placentation. Maternal-Fetal the Standard for 2017. Toronto, MyGOALS: Multidisciplinary Canada, February 2017. Medicine Academic Half Day, ON, Canada, February 2017. Gynecologic Oncology Annual Mount Sinai Hospital. Toronto, Maxwell C. Maternal Obesity. Lecture Series. Toronto, ON, Keunen J. Live Scan – Cervix. ON, Canada, February 2017. Grand Rounds, Sunnybrook Canada, March 2017. 20th Annual Obstetric Health Sciences Centre. Kingdom JC. Maternal Ultrasound: Setting the Lausman A. IUGR Toronto, ON, Canada. Circulating Angiogenesis- Standard for 2017. Toronto, Guidelines. Toronto Birth Regulating Proteins (PLGF Maxwell C. Expecting the ON, Canada, February 2017. Conference. Toronto, ON, and sFlt-1): Improving Unexpected: A Case of Canada, November 2016. Keunen J. CVS & Amnio Care for Women at Risk Ulcerative Colitis. Maternal Principals. Maternal of Pre-eclampsia. Grand Lausman A. New Concepts Fetal Medicine, Patient Care Fetal Medicine Fellowship Rounds, Mount Sinai Hospital, in IUGR. Queens University, Conference. Toronto, ON, Teaching Rounds, Mount Department of Obstetrics & Continuing Medical Canada, August 2016. Sinai Hospital. Toronto, Gynaecology. Toronto, ON, Education Day. Kingston, May T. The Role of Advanced ON, Canada, June 2016. Canada, February 2017. ON, Canada, October 2016. Laparoscopy in Gynaecologic Kingdom JC. Placenta Growth Kingdom JC, Van Mieghem T. Lausman A. Fetal Heart Oncology. Second Annual Factor (PlGF): A New Blood Differentiating Perspectives Rate Monitoring. St. Gynecologic Surgery Test for Clinicians to Manage on the Optimal Management Michael’s Hospital, PGY1 Conference. Toronto, ON, Suspected Hypertension or of Patients with Previous Boot Camp. Toronto, ON, Canada, September 2016. Fetal Growth Restriction. Pre-Eclampsia or IUGR – The Canada, June 2016. May T. Advances in Minimally SOGC/APOG Ontario Placenta Clinic vs. the Use of Librach CL. Human Umbilical Invasive Surgery in Gynecologic CME 2017. Toronto, ON, Aspirin. 13th Annual Obstetrical Cord Derived Stem Cell Oncology. Gynecologic Oncology Canada, December 2017. Malpractice: A Survival Technologies. Nursing Multidisciplinary Tumor Board, Guide for 2017. Toronto, ON, Kingdom JC. PlGF – Why, Journal Club. Toronto, ON, Princess Margaret Cancer Canada, January 2017. When, What and What Next? Canada, June 2016. Centre. Toronto, ON, Canada, Canadian Intrapartum Care Kingdom JC. Morbidly September 2016. Lee SK. Future of NICU Follow- Conference. Toronto, ON, Adhering Placentas. Up. Building Strong NICU McDermott CD. Managing your Canada, November 2017. Sonographer Rounds, Mount Families Symposium. Toronto, Patients’ Pelvic Floor. Everyday Sinai Hospital. Toronto, ON, Kingdom JC. Placenta ON, Canada, November 2016. Gynaecology Conference, Canada, December 2016. Growth Factor: Implications University of Toronto. Toronto, Lee SK. CIHR Foundation for Managing Suspected Kingdom JC. The Role of ON, Canada, November 2016. Scheme. IHDCYH Webinars. Pre-Eclampsia or IUGR. 15th Heparin for the Prevention of Toronto, ON, Canada, May 2017. McDermott CD. A Annual Refresher in Primary IUGR. 5th International Fetal

ANNUAL REPORT 2016/17 101

Urogynecologist’s Approach Evaluation of Male Fertility. Canada, January 2017. Canada, October 2016. to Chronic Pelvic Pain. Urology Department Rounds, Murphy KE. Zika: Update Murji A. Medical Management Pelvic Health Solutions 4th Mount Sinai Hospital. Toronto, and Review of Disagreement of Uterine Fibroids. Canadian Annual Symposium. Toronto, ON, Canada, November 2016. in Guidelines. OB Obstetrics and Gynaecology ON, Canada, April 2017. Moskovtsev SI. Malpractice: A Survival Review Program. Toronto, ON, Meffe F. Providing Medical Spermatogenesis PSL Guide for 2017. Toronto, ON, Canada, February 2017. Learners with Feedback. 420F/1420F Reproductive Canada, January 2017. Nagy A. Stem Cells “R” Department of Obstetrics Physiology. University of Murphy KE. Case Based Us. 1st Sun Life Gene and Gynecology Journal Toronto, Department of Learning - Hepatitis B. Academic Program in Club, Trillium Health Physiology. Toronto, ON, Mount Sinai Hospital. 12th Medical Science, High Partners. Mississauga, ON, Canada, October 2016. Annual Everyday Gynaecology School Student Competition Canada, September 2016. Murji A, Singh S. Debate on Conference - The Management Research Day. Toronto, ON, Meffe F. Menorrhagia and the Management of Fibroids. of Common Gynaecologic Canada, September 2016. Anemia: Old Friends. Women’s Ontario CME 2016 – The Conditions. Toronto, ON, Nagy A. Addressing Cell Health Symposium, St. Society of Gynecologic Oncology Canada, November 2106. Therapy Safety with Genome Michael’s Hospital. Toronto, of Canada. Toronto, ON, Murji A. Endometriosis. Editing. Student Society for ON, Canada, February 2017. Canada, December 2016. Gynaecology Academic Half Stem Cell Research, 2nd Annual Melamed N. Defining Fetal Murphy KE. Hepatitis B in Day, University of Toronto, Conference – Stem Cells: Growth. 5th International Fetal Pregnancy. Association of Department of Obstetrics The Next Generation. Toronto, Growth Meeting. Toronto, ON, Ontario Midwives. Toronto, ON, & Gynaecology. Toronto, ON, Canada, January 2017. Canada, November 2016. Canada, May 2017. ON, Canada, June 2017. Nagy A. Addressing Cell Melamed N. Timing of Murphy KE. Zika in Murji A. Adenomyosis: Therapy Safety with Genome Delivery in Women with Pregnancy. Association of Symptoms, Causes and Editing. Keenan Research Gestational Diabetes. BORN Ontario Midwives. Toronto, Treatment. 12th Annual Centre, St. Michael’s Annual Conference. Toronto, ON, Canada, May 2017. Everyday Gynaecology: The Hospital. Toronto, ON, ON, Canada, April 2017. Management of Common Canada, February 2017. Murphy KE. Late Preterm Gynaecologic Conditions. Melamed N. Integration Steroids. 2017 Refresher Okun N. Assisted Reproduction University of Toronto, of Growth Imaging into in Primary Maternity Care. and Birth Outcomes. 25th Department of Obstetrics & Management. Obstetrical Mount Sinai Hospital. Toronto, Annual Symposium New Gynaecology. Toronto, ON, Ultrasound Course. Toronto, ON, Canada, May 2017. Developments in Prenatal Canada, November 2016. ON, Canada, February 2017. Screening and Medical Murphy KE. Zika in Pregnancy. Murji A. Case Base Genetics. Mount Sinai Hospital. Moskovtsev SI. Automated Obstetric Medicine Rounds, Learning – A Case of Ectopic Toronto, ON, Canada, May 2017. Method to Identify Rare Sperm Mount Sinai Hospital. Toronto, Pregnancy. 12th Annual in Azoospermic in mTESE ON, Canada, April 2017. Okun N, Douggan S. Prenatal Everyday Gynaecology: The Sample. Fertility Rounds, Screening in Ontario: Past, Murphy KE. Introduction to Management of Common Mount Sinai Hospital. Toronto, Present and Future – Using Global Reproductive Health. Gynaecologic Conditions. ON, Canada, March 2017. Data to Inform Policy. 2017 Global Health Education University of Toronto, Born Conference. Toronto, Moskovtsev SI. Introduction Institute for Reproductive Department of Obstetrics & ON, Canada, April 2017. at Spermatogenesis and Health. Toronto, ON, Gynaecology. Toronto, ON, Andrology. University of Canada, March 2017. Canada, November 2016. Okun N. NIPT in the UK Toronto, Department of and Canada. 20th Annual Murphy KE. The New SOGC Murji A. Dysfunctional Engineering. Toronto, ON, Obstetric Ultrasound: Setting Guidelines on Hepatitis B. Uterine Bleeding. Annual Canada, January 2017. the Standard for 2017. Mount OB Malpractice: A Survival Clinic Day, William Osler Sinai Hospital. Toronto, ON, Moskovtsev SI. Laboratory Guide for 2017. Toronto, ON, Health System. Toronto, ON, Canada, February 2017.

102 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Local Lectures

Okun N. Case Presentations. Rogers I. Stem Cells 101, a Canada, November 2016. Department of Obstetrics & Genetics/DI/MFM Rounds. Stem Cell Primer. Cell Care and Gynaecology. Toronto, ON, Rogers I. Stem Cells from Trillium Health Partners. Inception Symposium. Toronto, Canada, November 2016. Umbilical Cord Blood and Mississauga, ON, Canada, ON, Canada, April 2017. Tissue have Therapeutic Selk A, McFaul S. Ontario February 2017. Rogers I. Umbilical Cord Blood Properties. Obstetrics and Colposcopy Update: Cases, Okun N. Case Presentations. and Tissue as a Source of iPSC Gynecology Group, Centenary Cases, Cases. Society Genetics/DI/MFM Rounds. for Advanced Cell Therapies. Hospital. Toronto, ON, of Obstetricians and Trillium Health Partners. Family Practice Rounds, St. Canada, November 2016. Gynaecologists of Canada Mississauga, ON, Canada, Joseph’s Hospital. Toronto, Regional Meeting. Toronto, Rogers I. Therapeutic November 2016. ON, Canada, March 2017. ON, Canada, December 2016. Uses for Umbilical Cord Okun N. Pitfalls in Genetic Rogers I. Pluripotent vs. blood and Umbilical Cord Selk A. The Aging Vulva. Testing. Obstetrical Multipotent Stem Cells for tissue Cells. Family Practice University of Toronto and Mount Malpractice: A Survival Replenishing the Blood Rounds, Cambridge Memorial Sinai Hospital, Department Guide for 2017. Mount System in Leukemia Patients. Hospital. Cambridge, ON, of Obstetrics & Gynaecology, Sinai Hospital. Toronto, ON, Stem Cell talks: Debate Canada, October 2016. 13th Annual Mature Women’s Canada, January 2017. with Dr. Rossant. Toronto, Health Care. Toronto, ON, Sallais J, Caniggia I. Cross- ON, Canada, March 2017. Canada, April 2017. Rogers I. Stem Cells for Talk between Oxygen and Drug Discovery, Cell Therapy Rogers I. Umbilical Cord Sphingolipid Metabolism Selk A. How your Body and Whole Organ Production. Blood Cells for Advanced In Human And Murine Changes in Pregnancy. Physiology summer student Stem Cell Therapies. Placental Development. Yolk II: Body and Brain. An talk, University of Toronto. Obstetrics and Gynaecology 34th Annual Research education event for women for Toronto, ON, Canada, June 2017. Rounds, Scarborough Day, University of Toronto International Women’s Day, General Hospital. Toronto, Department of Obstetrics The House and Mount Sinai Rogers I. Building a Pancreas ON, Canada, March 2017. & Gynaecology. Toronto, Hospital Foundation. Toronto, with Stem Cells and an ON, Canada, April 2017. ON, Canada, March 2017. Acellular Pancreas .Banting and Rogers I. Umbilical Cord Best Diabetes Centre. Toronto, Blood and Tissue Banking. Sallais J, Caniggia I. Cross- Shapiro H, Jones C, Bohnen ON, Canada, June 2017. CCRM/Industry Ontario Media Talk between Oxygen and J, Anderson G, Matlow A. Tour at Inception. Toronto, Sphingolipid Metabolism in Evaluation of a Pilot Leadership Rogers I. Advanced Cell Based ON, Canada, March 2017. Human and Murine Placental Program for Obstetrics and Therapies using Umbilical Cord Development. Institute of Gynecology Residents. Toronto Blood and Tissue Cells. Family Rogers I. Using Umbilical Medical Science Annual International Summit on Medicine Clinical Rounds, Cord Blood and Tissue Cells for Scientific Day, Toronto, Leadership Education for Niagara Health, Obstetrics and Advanced Stem Cell Therapies. ON, Canada, May 2017. Physicians. Niagara Falls, ON, Gynecology. Family Medicine Family Practice Rounds, Canada, September 2016. Clinical St. Catherine’s, Sunnybrook Hospital. Toronto, Selk A. What’s New in ON, Canada, June 2017. ON, Canada, February 2017. Vulvar Dermatoses. Toronto Shynlova O. Maternal Dermatologic Society, Atlantic Peripheral Blood Leukocytes Rogers I. Using Urine Derived Rogers I. UCB, UCT and iPSC Dermatological Conference. as Biomarkers of Pregnancy iPSC to Treat Incontinence. for Regenerative Medicine. Toronto, ON, Canada, May 2017. Complications. Annual Regenerative Medicine Coffee Family Practice Rounds, Trillium Meeting of the International Hour with Dr. Kellie Murphy. Health Centre. Mississauga, Selk A. Vulvar 911 – Society for Biological and Toronto, ON, Canada, June 2017. ON, Canada, December 2016. Common Problems and Environmental Repositories. Easy Answers. 12th Annual Rogers I. Production of Rogers I. Induced Pluripotent Toronto,ON, Canada, May 2017. Everyday Gynaecology: The Whole Organs from Stem Stem Cells from Urine. Management of Common Solnik J. Advances in Cells: Building a Kidney. Urogynecology Rounds, Sinai Gynaecologic Conditions. Female Pelvic Medicine and OIRM Symposium. Toronto, Health System. Toronto, ON, University of Toronto, Reconstructive Pelvic Surgery. ON, Canada, May 2017.

ANNUAL REPORT 2016/17 103 Local Lectures

University of Toronto. Toronto, Van Mieghem T. Live Microfloralogues. Toronto Public of Toronto, Department of ON, Canada, May 2016. Scan First Trimester. 20th Health Sexual Health Training Family Practice. Toronto, Annual Obstetric Ultrasound and Education Session. Toronto, ON, Canada, July 2016. Steinberg W. HPV and Meeting: Setting the Standard ON, Canada, May 2017. Vaccination: Translating Yudin M. HIV: Clinical Care Here for 2017. Toronto, ON, Knowledge into Action. The Yudin M. Vaginitis: How to and Abroad. Global Refugee Canada, February 2017. Society of Obstetricians Manage this Common Problem. and Immigrant Women’s Health and Gynaecologists of Van Mieghem T. Fetal Resident Teaching Lecture Continuing Medical Education Canada. Toronto, ON, Cardiac Dysfunction. 20th Series, University of Toronto, Course. University of Toronto, Canada, October 2017. Annual Obstetric Ultrasound Department of Obstetrics Department of Obstetrics Meeting: Setting the Standard and Gynecology. Toronto, and Gynecology. Toronto, Steinberg W. Clinical PEARLS for 2017. Toronto, ON, ON, Canada, April 2017. ON, Canada, May 2016. for the Medical Management Canada, February 2017. of Uterine Fibroids. University Yudin M. Viral Infections Zigras T, Brar H, Wijeysundera of Toronto. Toronto, ON, Van Mieghem T. Fetal Cardiac in Pregnancy. Toronto East H, Ferguson S. A Decision Canada, October 2016. Screening: Guidelines and Health Network Drugs and Analysis of the Treatment Techniques. Toronto Symposium Therapeutics Update, Michael Strategies for Pelvic Lymph Ternamian A. History and in Fetal Cardiology: From Basics Garron Hospital. Toronto, Node Positive Stage IB1 Evolution of Hysteroscopy. to State of the Art. Toronto, ON, Canada, April 2017. Cervical Cancer. 34th The Art of Modern Out- ON, Canada, October 2016. Annual Research Day, Patient Hysteroscopy and Yudin M. A Balancing Act: University of Toronto an Introduction to Trans- Van Mieghem T. First Considering HIV Status and Department of Obstetrics vaginal Hydro-Laparoscopy Trimester Echocardiography: Psychiatric Vulnerability & Gynaecology. Toronto, STORZ. Hysteroscopy What is Possible and How. in Pregnancy and the ON, Canada, April 2017. Symposium. Toronto, ON, Toronto Symposium in Fetal Postpartum Period. Casey Canada, October 2016. Cardiology: From Basics to House HIV/AIDS and Mental Zigras T, Ferguson S. A State of the Art. Toronto, ON, Health Series. Toronto, ON, Decision Analysis of the Ternamian A. Hysteroscopic Canada, October 2016. Canada, March 2017. Treatment Strategies for Pelvic Management of Sub-Mucous Lymph Node Positive Stage Fibroids. The Art of Modern Van Mieghem T. Are our Yudin M. Preconception IB1 Cervical Cancer. IHPME Out-Patient Hysteroscopy and Caesarean Section Rates Too Counseling in the Zika Annual Research Day. Toronto, an Introduction to Trans- High. Society of Obstetricians Area. St. Michael’s Hospital ON, Canada, April 2017. vaginal Hydro-Laparoscopy and Gynaecologists of Annual Women’s Health STORZ. Hysteroscopy Toronto Debate. Toronto, ON, Symposium. St. Michael’s Vilos G, Vilos A, Abu-Rafea Symposium. Toronto, ON, Canada, October 2016. Hospital, University of Toronto, B, Ternamian A. Evolution of Canada, October 2016. Department of Obstetrics a Safer Laparoscopic Entry Van Mieghem T, Kingdom JC. and Gynecology. Toronto, ON, Utilizing a Novel Stepwise Ternamian A. Diagnostic and Managing Women with a History Canada, February 2017. Closed Technique. Canadian Operative Hysteroscopy. APOG of Severe Pre-Eclampsia: The Symposium on Minimally Annual Minimally Invasive Placental Clinic vs. Aspirin Yudin M. Zika Virus and Invasive Gynecologic Surgery. Surgery Workshop for Residents from Early Gestation. 12th Pregnancy: More Questions Victoria College, University and Fellows. Toronto, ON, Annual Obstetric Malpractice than Answers. Scarborough of Toronto. Toronto, ON, Canada, November 2016. Conference. Toronto, ON, Hospital, Continuing Medical Canada, April 2016. Canada, January 2017. Education. Toronto, ON, Ternamian A. Complications of Canada, January 2017. Operative Hysteroscopy. APOG Yudin M. Immunization in Annual Minimally Invasive Pregnancy. Association Yudin M. Vaginitis: Surgery Workshop for Residents of Ontario Midwives Management for the Family and Fellows. Toronto, ON, webinar. Toronto, ON, Doctor. Family Practice Canada, November 2016. Canada, April 2016. Academic Half Day, St. Michael’s Hospital, University Yudin M. Vaginal

104 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Presentations

ANNUAL REPORT 2016/17 105 INTERNATIONAL ABSTRACT PRESENTATIONS

Abadde J, Tagliaferro A, Ermini L, Post M, Meeting. Orlando, FL, USA, March 2017. S, Spits C, Keymolen K, Seneca S, Tome St, Caniggia I. Novel Insight into Insulin- Miron I, Letourneau J, Liang M, Choufani Alahari S, Caniggia I. JMJD6-mediated dependent Changes in Mitochondrial S, Weksberg R, Wilson MD, Zdenek S, Histone Demethylation in Preeclampsia is Dynamics in Gestational Diabetes Gagnon C, Musova Z, Chitayat D, Shannon Compromised Due to Reduced Intracellular Mellitus. International Federation of P, Mathieu J, Sermon K, Pearson CE. CpG Iron Availability. International Federation Placental Associations. Manchester, Methylation, a Parent-of-origin Effect for of Placental Associations. Manchester, United Kingdom, August 2017. Maternal-based Transmission of Congenital United Kingdom, August 2017. Myotonic Dystrophy. International Abbasi N, Kolomietz E, Moore A, Chiu P, Alayed N, Okun N, Chong K, Chitayat D, Myotonic Dystrophy Consortium. San Chong K, Ryan G, Chitayat D. Microarray Kolomietz E. Chromosomal Microarray Francisco, CA, USA, September 2017. Abnormalities in Prenatally Diagnosed as a First Tier Test Following Diagnostic Omphaloceles. 20th International Barretto T, Park E, Liu E, Gauthier-Fisher Prenatal Procedures, The Toronto Conference on Prenatal Diagnosis and A, Gallagher D, Librach CL, Baker A. Mount Sinai Hospital Experience. Therapy. Berlin, Germany, July 2016. Blood Brain Barrier Integrity and Edema International Society of Ultrasound in Formation after Moderate Traumatic Abbasi N, Moore A, Weksberg R, Obstetrics and Gynaecology, 26th World Brain Injury is Improved with Human Shuman S, Steele L, Chiu P, Ryan G, Congress on Ultrasound in Obstetrics Umbilical Cord Perivascular Cell Therapy. Chitayat D. Beckwith-Wiedemann and Gynecology. Rome, Italy, September International Society for Cellular Therapy. Syndrome in Prenatally Diagnosed 2016. Rome, Italy, September 2016. London, United Kingdom, May 2017. Omphaloceles. 20th International Alsayegh E, Melamed N. Optimal Conference on Prenatal Diagnosis and Bhattacharjee J, Natta GK, Real AHM, Timing of Antenatal Corticosteroids in Therapy. Berlin, Germany, July 2016. Rahman MM, Caniggia I, Bhuiyan MU. Women with Bleeding Placenta Previa. Materno-fetal and Placental Relationship Abramov R, Antes R, Kuznyetsov V, Zaver Society for Maternal Fetal Medicine, in Zebu and Crossbred Cattle. International S, Balakier H, Madjunkova S, Librach 37th Annual Pregnancy Meeting. Las Conference on Reproductive Biology and CL. Morphological Blastocyst Grade Vegas, NV, USA, January 2017. Comparative Endocrinology (ICRBCE) and is not a Determinant for Implantation Andany N, Kaida A, de Pokomandy A, the 35th Annual Meeting of the Society of Euploid Embryos. International Wang L, Kennedy V, Yudin MH, Webster for Reproductive Biology and Comparative Conference on Preimplantation Genetics. K, Benoit A, Loutfy M. Early Onset Endocrinology (SRBCE-XXXV). University Valencia, Spain, March 2017. Menopause Among Women Living with HIV of Hyderabad, India, February 2017. Acuna S, Zaffar N, Bhagra C, Ross H, in Canada. Conference on Retroviruses and Berger H, Srivaratharajah K, Abramson Silversides C, D’Souza R. Pregnancy Opportunistic Infections, Annual Scientific B, Jairam J, Park A, Ray JG. First Outcomes of Cardiothoracic Transplant Meeting. Seattle, WA, USA, February 2017. Trimester Maternal Visceral Adipose Recipients: A Systematic Review and Baja H, Retnakaran R, Zinman B, Connelly Tissue Thickness is Independently Meta-analysis. Society for Maternal Fetal PW, Hanley AJ, Sermer M, Qi Y. Biomarkers Associated with Postpartum Maternal Medicine, 37th Annual Pregnancy Meeting. of Vascular Injury After Recent Glucose Adiposity. International Society of Las Vegas, NV, USA, January 2017. Intolerance in Pregnancy. American Ultrasound in Obstetrics and Gynaecology. Alahari S, Rolfo A, Caniggia I. Hypoxia Diabetes Association, 77th Scientific Vienna, Austria, September 2017. and Iron Imbalance Impairs JMJD6- Sessions. San Diego, CA, USA, June 2017. Berger H, Ray JG, De Souza LR, Park AL, mediated Histone Demethylation of Balogun K, Guzman M, Papp E, Loutfy M, Connelly PW, Bujold E. Viceral Adiposity VHL in Preeclampsia. International Yudin MH, MacGillivray J, Murphy KE, in Early Pregnancy and the Risk of Federation of Placenta Associations. Walmsley S, Silverman M, Serghides L. Preeclampsia and Preterm Birth in the Portland, OR, USA, September 2016. Protease Inhibitor Based cART is Associated Session. International Society of Ultrasound Alahari S, Caniggia I. Oxygen-dependent with High Estradiol Levels in Pregnancy. in Obstetrics and Gynaecology, 26th World JMJD6 Regulation of Fibronectin 7th International Workshop on HIV and Congress on Ultrasound in Obstetrics and Synthesis and Assembly in the Human Women. Seattle, WA, USA, February 2017. Gynecology. Rome, Italy, September 2016. Placenta. Society for Reproductive Barbe L, Lanni S, Lopez-Castel A, Franck Bernardini MQ, Gien LT, Giede C, Investigation, 64th Annual Scientific Samouelian V, Steede H, Ferguson SE,

106 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY INTERNATIONAL ABSTRACT PRESENTATIONS

Renkosinskif B, Abitbolg J, Warkush T, Lei American Primary Care Research Group, D’Souza R, Tomlinson G, McKelvey K, Krahn T, Martin V, Covens A, Panzarella T, Gotlieb Annual Scientific Meeting. Colorado M, Murphy KE, Sander B. Preferences of WH. GOC2: A Multi-centre Prospective Springs, CO, USA, November 2016. Pregnant Women and Family Members for Trial Comparing Open, Laparoscopic and Combined Maternal and Fetal Health States Burchell AN, Kendall C, Cheng S, Antoniou Robotic Surgical Outcomes in Women with Arising from the Use of Anticoagulation T, Bayoumi AM, Glazier R, Lofters A, Endometrial Cancer. Part A: Peri-operative in Pregnancy. American Congress Raboud J, Yudin MH, Loutfy M. Decline in Outcomes. Society of Gynecologic Oncology, of Obstetricians and Gynaecologists Annual Pap Testing Among HIV-positive 48th Annual Meeting on Women’s Cancers. Meeting. San Diego, CA, USA, May 2017. Women in Ontario, Canada. Conference National Harbor, MD, USA, March 2017. on Retroviruses and Opportunistic D’Souza R, Thurman R, Sermer M, Siu S, Bernardini MQ. Cost-effectiveness of Infections, Annual Scientific Meeting. Duffy J, Silversides C. Developing a Core Sentinel Node Biopsy and Pathological Boston, MA, USA, February 2016. Outcome Set for Pregnant Women with Ultrastaging in Patients with Early Stage Cardiac Disease. The COMET VI Meeting. Chauvin S, Secter M, Selk A. Vaccinating Endometroid Adenocarcinoma of the Amsterdam, Netherlands, November 2016. the Boys: A Pilot Study of Gynaecologists’ Uterus. Society of Gynecologic Oncology, and Otolaryngologists’ Attitudes Toward D’Souza R, Tomlinson G, McKelvey K, 48th Annual Meeting on Women’s Cancers. Male Vaccination. International Federation Wuebbolt D, Nguyen V, Peterson W, National Harbor, MD, USA, March 2017. for Cervical Pathology & Colposcopy World Bremner K, Krahn M, Murphy KE, Sander Bernardini MQ. TP53 Expression Status Congress. Orlando, FL, USA, April 2017. B. Preferences of Pregnant Women and and Association with Outcome within Family Members for Combined Maternal Coroneos MK, Shore EM, McDermott Grade 3 Endometrioid Carcinomas of the and Fetal Health States Arising from C. Female Pelvic Medicine and Endometrium. United States & Canadian the use of Anticoagulation in Pregnancy. Reconstructive Surgery in Canada: A Academy of Pathology’s 106th Annual The COMET VI Meeting. Amsterdam, Survey of Obstetrician-gynaecologists Meeting. San Antonio, TX, USA, March 2017. Netherlands, November 2016. and Urologists. Association of Professors Bhasin A, Gonzalez A, Zaffar N, Mullin S, of Obstetrics and Gynaecology. D’Souza R, Thomas H, Wuebbolt D, Nguyen Hui D, D’Souza R, Chan C, Hadunewich Denver, CO, USA, October 2016. V, Sermer M, Krahn M, Silversides C. M. Pregnancy Outcomes in Women on Preferences of Pregnant Women with Costain G, Inbar-Feigenberg M, Saleh Intensive Hemodialysis Compared to Cardiac Disease for Combined Maternal- M, Yaniv-Salem S, Ryan G, Morgen Renal Transplant Recipients. American fetal Health States. The COMET VI Meeting. E, Goh E, Nishimura G, Chitayat D. Society of Nephrology Conference. Amsterdam, Netherlands, November 2016. Prenatal Indications of Mucolipidosis Chicago, IL, USA, November 2016. Type II (I-cell Disease): Report of Two D’Souza R, McKelvey K, Murphy KE, Sander Brar H, Bouchard-Fortier G, Bernardini Cases. 21st International Conference B. Decision Analysis Studies Involving MQ, May T, Laframboise S, Vicus on Prenatal Diagnosis and Therapy. the Management of Pregnant Women: A D, Gien L, Covens A, Ferguson S. San Diego, CA, USA, July 2017. Systematic Review. American Congress Cost-effectiveness of Sentinel Node of Obstetricians and Gynaecologists Derzko C, Rohrich S, Chudecka A, Panay Biopsy and Pathological Ultrastaging in Meeting. San Diego, CA, USA, May 2017. N. Does Age at Start of Treatment for Patients with Early Stage Endometroid Vaginal Atrophy Predict Response to Duan AQ, Zhu MY, Portnoy S, Milligan N, Adenocarcinoma of the Uterus. Society Vaginal Estrogen Therapy. International Lim JM, Keunen J, Macgowan C, Sled J, of Gynecologic Oncology 48th Annual Menopause Society, Biannual Meeting. Kingdom JC, Seed M. Fetal Brain in Liver Meeting on Women’s Cancers. National Prague, Czech, September 2016. Volume Ratio Measured by MRI is a Useful Harbor, MD, USA, March 2017. Indicator of IUGR In Vivo in Late Gestation. D’Souza R, Thomas H, Wuebbolt D, Burchell AN, Kendall C, Cheng SY, Antoniou International Society of Ultrasound in Murphy KE, Silversides C. Preferences T, Bayoumi AM, Cotterchio M, Glazier Obstetrics and Gynaecology, 26th World of Pregnant Women with Cardiac Disease RH, Yudin MH, Lofters AK, Loutfy M. Congress on Ultrasound in Obstetrics and for Maternal-fetal Outcomes Related to Characteristics of HIV-positive Women Gynecology. Rome, Italy, September 2016. their Pregnancies. American Congress not Undergoing Cervical Cancer Screening of Obstetricians and Gynaecologists Dunlop K, Eckler R, Rosen A, Murphy over an Extended Interval: Findings from Meeting. San Diego, CA, USA, May 2017. KE, D’Souza R. Reliability of Visual a Universal Healthcare Setting. North

ANNUAL REPORT 2016/17 107

Estimation of Intrapartum Blood Loss. Gat I, Tang K, Kuznyetsov V, Abramov R, Contrast-Enhanced MRI, Diffusion- American Congress of Obstetricians Antes R, Moskovtsev SI, Librach CL. Does Weighted MRI, and FDG Positron Emission and Gynaecologists Meeting. San the Degree of Sperm DNA Fragmentation Tomography Imaging in Brachytherapy for Diego, CA, USA, May 2017. have an Effect on the Embryo Aneuploidy Cervix Cancer. ASTRO Annual Meeting. Rate? 66th Annual American Society of Boston, MA, USA, September 2016. Dunlop K, Eckler R, Rosen A, Murphy KE, Reproductive Medicine Meeting. Salt D’Souza R. Reliability of Visual Estimation Hilton JK, Liu K, Laskin CA, Havelock Lake City, UT, USA, October 2016. of Intrapartum Blood Loss. International J. Effect of Endometrial Biopsy on In Conference for Healthcare and Medical Gat I, Fuchs-Weizman N, Kenigsberg S, Vitro Fertilization Clinical Pregnancy Students. Dublin, Ireland, February 2017. Wyse B, Zohni K, Russell S, Kaballero Rates – A Randomized, Multicentre J, Balakier H, Librach CL. What is the Study. 66th Annual American Society Eckler R, Rosen A, Dunlop K, Murphy Impact of Ovulation Trigger Regimen on of Reproductive Medicine Meeting. Salt KE, D’Souza R. Prospective Validation of Cumulus Cells’ Transcriptome among Lake City, Utah, USA, October 2016. Formulae for the Estimations of Intrapartum High and Normal Responder Patients? An Blood Loss. American Congress of Hogen L, Vicus D, Covens A. Is Extensive Investigation by Next Generation Obstetricians and Gynaecologists Adjuvant Treatment Beneficial For Sequencing. Israeli Fertility Annual Meeting. San Diego, CA, USA, May 2017. Surgical Stage I Ovarian Clear Cell Conference. Tel Aviv, Israel, May 2017. Carcinoma 16th Biennial Meeting of Eckler R, Rosen A, Dunlop K, Murphy Gat I, Tang K, Quach K, Kuznyetsov V, the International Gynecologic Cancer KE, D’Souza R. Prospective Validation Antes R, Zohni K, Felice M, Librach CL. Society. Lisbon, Portugal, October 2016. of Formulae for the Estimations of Sperm DNA Fragmentation Index does Intrapartum Blood Loss. Jefferson Research Hum C, Injeyan M, Shannon P, Blaser not Correlate the Rate of Blastocyst Day. Philadelphia, USA, March 2017. S, Malinowski AK, Kingdom JC, Aneuploidy in Autologous IVF Cycles. An Chitayat D. COL4A1 Gene Mutation: Farine T, Shynlova O, Lye S. Comparative Extensive Investigation by Next Generation From Fetal Microangiopathy to Maternal Characteristics of Myometrial and Sequencing. Israeli Fertility Annual Deep Vein Thrombosis with Pulmonary Decidual Chemokines Responsible for Conference. Tel Aviv, Israel, May 2017. Embolism. American College of Medical the Infiltration of Peripheral Leukocytes Gat I, Maghen L, Shlush E, Quach K, Genetics and Genomics Meeting. into Term Uterine Tissues. Society for Felice M, Zohni K, Kenigsberg S, Wyse B, Phoenix, AZ, USA, March 2017. Reproductive Investigation, 64th Annual Gauthier-Fisher A, Librach CL. In Vitro Meeting. Orlando, FL, USA, March 2017. Iqbal F, Szaraz P, Wu J, Gauthier-Fisher Testicular Niche Modelling: The Ratio of A, Li RK, Librach CL. Co-administration Farrell A, Caniggia I. AMOT is a Novel Spermatagonial Stem Cells (SSCs) to of First Trimester Umbilical Cord-derived Target for TGFβ Mediated Disruption of Supporting Somatic Cells is Critical for Perivascular Cells (FTM HUCPVCs) with Trophoblast Cell Polarity in the Human Optimal SSC Proliferation. An Extensive Endothelial Progenitor Cells (EPCs) Leads to Placenta. International Federation of Investigation by Next Generation Enhanced Angiogenesis, both In Vitro and Placental Associations. Manchester, Sequencing. Israeli Fertility Annual In Vivo, Compared to Either Cell Type Alone. United Kingdom, August 2017. Conference. Tel Aviv, Israel, May 2017. International Society for Cellular Therapy. Ferguson SE, Gotlieb WH, Gien LT, Giede Goldberg H, Allen L, Kives S. Impact of an London, United Kingdom, May 2017. C, Samouelian V, Steed H, Renkosinskia Evidence Based Multidisciplinary Algorithm Iqbal F, Szaraz P, Wu J, Gauthier-Fisher A, Li B, Abitbolg J, Warkush T, Lei T, Martin for the Management of Adnexal Masses in RK, Librach CL. First Trimester Umbilical V, Panzarella T, Covens A, Bernardini the Pediatric Population. North American Cord Perivascular Cells (FTM HUCPVCs) MQ. GOC2: A Multi-centre Prospective Society of Pediatric and Adolescent Show Superior Angiogenic Potential Trial Comparing Open, Laparoscopic Gynaecology, 31st Annual Clinical in Angiogenic Potency Assays when and Robotic Surgical Outcomes in Meeting. Chicago, IL, USA, April 2017. Compared to Term HUCPVCS and Bone Women with Endometrial Cancer. Part Han K, Croke JM, Metser U, Foltz WD, Xie Marrow Mesenchumal Stromal Cells. Basic B: Patient-reported Outcomes. Society J, Shek T, Driscoll B, Menard C, Vines D, Cardiovascular Sciences 2016 Scientific of Gynecologic Oncology, 48th Annual Coolens C, Simeonov A, Beiki-Ardakani A, Sessions. Phoenix, AZ, USA, July 2016. Meeting on Women’s Cancers. National Leung EW, Levin W, Fyles TW, Milosevic Harbor, MD, USA, March 2017. Iqbal F, Szaraz P, Kenigsberg S, Gautheir- M. Prospective Study of Dynamic

108 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY International Abstract Presentations

Fisher A, Librach CL. First Trimester Inhibits LPS-induced Cytokine Production of Obstetricians and Gynaecologists Umbilical Cord Perivascular Cells (FTM by Human Myometrial Cells. Society for Meeting. San Diego, CA, USA, May 2017. HUCPVCs) Maintain High Expression Reproductive Investigation, 64th Annual Kurjanowicz P, Gelis P, Komosa M, Levels of Angiogenic Factors and have Meeting. Orlando, FL, USA, March 2017. Moskovtsev SI, Librach CL. Application Superior Pro-angiogenic Effects on King CP, Sheehan C, Aggarwal A, of the haloFISH Assay to Detect Distinct Endothelial Networks when Compared Allen L, Spitzer R. A Use of ACASI to Populations of Chromosomal (Chr) and to Term HUCPVCs and BMSCs in an Gather Information on Risk Behaviours Extrachromosomal (EC) Telomeric DNA Ex-vivo Rat Aortic Ring Assay. Basic in a Referral Population of Pregnant in the Human Sperm Genome. Telomeres Cardiovascular Sciences Scientific Adolescents. North American and Telomerase in Health and Disease Sessions. Phoenix, AZ, USA, July 2016. Society of Pediatric and Adolescent Meeting. Paris, France, October 2016. Jodar M, Sendler E, Moskovstev S, Librach Gynaecology, 31st Annual Clinical Kuznyetsov V, Antes R, Caballaro J, CL, Goodrich R, Swanson S, Hauser R, Meeting. Chicago, IL, USA, April 2017. Madjunkova S, Librach CL. Is there Diamond M, Krawetz SA. Diagnostic Value King C, Goldberg H, Jain L, Allen L, a Relationship between Blastocyst of Sperm RNA in Idiopathic Infertility. Kives S, Aggarwal A, Spitzer R. Development and Aneuploidy Rate? International Congress of Andrology. Bacterial Vaginosis in the Pregnant CoGEN World Conference. Barcelona, Copenhagen, Denmark, May 2017. Adolescent Population: Screening and Spain, September 2016. Khan S, Loutfy M, Yudin MH, Read S, Treatment in a Dedicated Adolescent Magee L, Lapinsky S, Seaward G, Bhutta Bitnun A, Kennedy V. “It’s Not Easy”: Prenatal Program. North American Z, Quereshi R, Irfan S, Ganzevoort JW, Infant Feeding in the HIV Context in Society of Pediatric and Adolescent de Pont AMC, Mol B, Cecatti G, Vasquez a Resource-rich Setting – Strengths, Gynaecology, 31st Annual Clinical D, Aphalo V, Goffman D, Chazotte C, Challenges and Choices. 7th International Meeting. Chicago, IL, USA, April 2017. Wallace E, Crozier T, Duan T, Zhou V, Geary Workshop on HIV and Women. Koby L, Keating S, Malinowski A, Murphy M, Bowen M, McAuliffe F, O’Herlihy C, Seattle, WA, USA, February 2017. KE, D’Souza R. Chronic Intervillositis – Togal T, Demirkiran O, Lataifeh I, Tadros Khan S, Kennedy V, Loutfy M, Yudin Clinical Biochemical and Radiological R. Precision Medicine for Pregnant and MH, Read S, Bitnun A. Infant Feeding in Associations. American Congress of Recently Pregnant Women Receiving HIV in Canada: Clinical and Research Obstetricians and Gynaecologists Critical Care: The CIPHER Collaborative Priority Meeting. 7th International Meeting. San Diego, CA, USA, May 2017. Integrated Pregnancy High-dependency Workshop on HIV and Women. Estimate of Risk Model. International Kfouri J, Gundy S, Faghfoury H, Seattle, WA, USA, February 2017. Society of Obstetric Medicine Congress. D’Souza R. Pregnancy Outcomes in Cape town, South Africa, March 2017. Kibel M, Melamed N. Fetal Growth Patients with MELAS Syndrome – A Restriction is Associated with Different Systematic Review. American Congress Lazier J, Injeyan M, Taylor G, Shannon Pattern of Placental Abnormalities of Obstetricians and Gynaecologists P, Whittle W, Chitayat D. Neu Laxova in Twin and Singleton Pregnancies. Meeting. San Diego, CA, USA, May 2017. Syndrome Caused by a Mutation in PHGDH Society for Maternal Fetal Medicine, in a Pakistani Family. 20th International Kolomietz E, Alayed N, Okun N, Chitayat 37th Annual Pregnancy Meeting. Las Conference on Prenatal Diagnosis and D, Noor A. Chromosomal Microarray as Vegas, NV, USA, January 2017. Therapy. Berlin, Germany, July 2016. a First Tier Test Following Diagnostic Kim B, Shynlova O, Bocking A, Lye S. Prenatal Procedure. The Toronto Mount Lazier J, Millar K, Keating S, Whittle W, Differential Effects of Five Lactobacilli Sinai Hospital Experience. 44th Biennial Weksberg R, Cytrnbaum C, Chitayat D. Strains on Infection-Induced Cytokine American Cytogenetics Conference. Russell-Silver Syndrome: Prenatal and Production by Human Myometrial Sunriver, OR, USA, June 2016. Placental Findings. 20th International Cells. Society for Reproductive Conference on Prenatal Diagnosis and Komorowski A, Zaffar N, Shah P, Investigation, 64th Annual Meeting. Therapy. Berlin, Germany, July 2016. Murphy KE, D’Souza R. The Use of Orlando, FL, USA, March 2017. Haemoglobin and Haematocrit Values Lennox G, Covens A. Can Sentinel Kim B, Shynlova O, Lye S. Probiotic to Estimate Intrapartum Blood Loss: A Lymph Node Biopsy Replace Pelvic Lactobacillus Rhamnosus GR-1 Supernatant Systematic Review. American Congress Lymphadenectomy for Early Cervical

ANNUAL REPORT 2016/17 109

Cancer? 16th Biennial Meeting of the Fluid from Twin-twin Transfusion McLaughlin K, Baczyk D, Potts A, International Gynecologic Cancer Society. Syndrome Recipient Twins in Relation to Hladunewich M, Parker J, Kingdom JC. Lisbon, Portugal, October 2016. Treatment and Fetal Cardiovascular Risk. Low-molecular Weight Heparin Improves International Society of Ultrasound in Endothelial Function in Pregnant Women Li A, Lee P. Patients’ Perspectives Obstetrics and Gynaecology, 26th World at High-risk of Preeclampsia. American on Vaginal Mesh Use in Pelvic Congress on Ultrasound in Obstetrics and Heart Association Scientific Sessions. Reconstructive Surgery prior to and Gynecology. Rome, Italy, September 2016. New Orleans, LA, USA, November 2016. after Initial Medical Consultation. American Association of Gynecologic Mackie P, Wang J, Moskovtsev SI, Librach Melamed N. Placental Abnormalities in Laparoscopists Annual Congress. CL. Isolation of Target Extracellular Vesicles Pregnancies Complicated by Preeclampsia Orlando, FL, USA, November 2016. Found in Seminal Fluid and Other Viscous Differ Between Twins and Singletons. Protein-rich Biological Samples Using Society for Maternal Fetal Medicine, Liang Q, Monetti C, Shutova M, Nagy A. A Magnetic Bead Immunoisolation. 49th 37th Annual Pregnancy Meeting. Las Leap Forward for Safety in Cell Therapies. Society for the Study of Reproduction. Vegas, NV, USA, January 2017. International Stem Cell. 15th Annual San Diego, CA, USA, July 2016. Meeting International Society for Stem Cell Murji A, Laberge P, Singh S, Leyland Research. Boston, MA, USA, June 2017. Malinowski A, Shehata N, D’Souza R. N, Polsky J, Jackson R, Fortin C, Vilos Constructing a Core Outcome Set for A, Sanders B, Uretsky A, Thiel J, Garzon Lichtman AS, Goff B, Parker W, Mehra Venous Thromboembolism in Pregnancy and D, Lamontagne A, Vilos G. History of N, Shore EM, Lefebvre GG, Chiang A, the Puerperium. The COMET VI Meeting. Pharmacologic and Surgical Interventions Lenin J JR, Schreuder HWR. Improving Amsterdam, Netherlands, November 2016. Among Canadian Women Presenting with Cognitive Surgical Knowledge in OBGYN Symptomatic Uterine Fibroids. Society for Residents Using an Interactive Computer- Malinowski A, Daru J, Shehata N, D’Souza Reproductive Investigation, 64th Annual Based Laparoscopic Hysterectomy R. Constructing a Core Outcome Set Meeting. Orlando, FL, USA, March 2016. Trainer. American Association of for Iron Deficiency and Ironc Deficiency Gynecologic Laparoscopists. Orlando, Anemia in Pregnancy and Postpartum. Myles-Reid, Chitayat D, Kolomietz FL, USA, November 2016. The COMET VI Meeting. Amsterdam, E. Successful Use of Preimplantation Netherlands, November 2016. Diagnosis for a Rare de Novo Chromosomal Lim JM, Muthusami P, Madathil S, Zhu Rearrangement Involving a Ring MY, Saini B, Porayette P, Macgowan C, Maloney AM, Armando L, Allen L, Curry Chromosome 11 with a Neocentromere. Sled J, Kingdom JC, Seed M, Miller S. S, Malkin E, Gupta A. Development of a 21st International Conference on Cerebral Oxygen Delivery, Brain Growth Pediatric Oncology Fertility Preservation Prenatal Diagnosis and Therapy. and White Matter Maturation are Reduced Program: Lessons Learned and Challenges San Diego, CA, USA, July 2017. in Congenital Heart Disease Fetuses. Yet to Conquer. 48th Congress of The International Society of Ultrasound in International Society of Paediatric Nadeem L, Romero H, Shynlova O, Obstetrics and Gynaecology, 26th World Oncology. Dublin, Ireland, December 2016. Mesiano S, Lye S. Human Labour: A Joint Congress on Ultrasound in Obstetrics and Venture of PRA and ERα. Society for McDermott CD. Female Pelvic Medicine Gynecology. Rome, Italy, September 2016. Reproductive Investigation, 64th Annual and Reconstructive Surgery in Canada: Meeting. Orlando, FL, USA, March 2017. Lipton N, Mackie P, Lye K, Lopez L, Iqbal A Survey of Obstetrician-gynaecologists F, Szaraz P, Kenigsberg S, Gallagher D, and Urologists. American Urogynecology Nica AI, Cesari M, Covens A, Vicus Gauthier-Fisher A, Librach CL. Extracellular Society, Annual Clinical Meeting. D, Kupets R, Osborne R, Gien LT. Vesicles Derived from Human Umbilical Denver, CO, USA, September 2016. Sentinel Lymph Nodes in Vulvar Cancer: Cord Perivascular Cells (HUCPVCs): A Management Dilemmas in Patients McGowan K, Malinowski AK, Whittle Potential Non-cell for Regnerative Therapy. with Positive Nodes and Larger Tumors. W, Minden M, Schuh A, Shehata N. International Society of Extracellular Society of Gynecologic Oncology, 48th Aplastic Anemia in Pregnancy – A Single Vesicles. Toronto, ON, Canada, May 2017. Annual Meeting on Women’s Cancers. Centre, North American Case Series. The National Harbor, MD, USA, March 2017. Mackie FL, Dunn WB, Allwood JB, Van 58th American Society of Haematology, Mieghem T, Morris RK, Fox CE, Kilby Annual Meeting and Exposition. San Nguyen V, Wuebbolt D, Thomas H, Murphy MD. Metabolomic Changes in Amniotic Diego, CA, USA, December 2016. KE, D’Souza R. Iron Deficiency Anaemia

110 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY International Abstract Presentations

and Treatment Options. American Congress Phillips M, Malinowski AK, Dolan S, Ananth Shah R, Xia C, Krailo M, Amatruda J, Arul G, of Obstetricians and Gynaecologists C, Catalano P, Hines E, Kirby R, Klebanoff Bilmire D, Brady W, Covens A, Gershenson Meeting. San Diego, CA, USA, May 2017. M, Mulvhill J, Simhan H, Wright R, Ramos D, Hale J, Hurteau J, Murray M, Nicholson EM, Kilpatrick L, Hendershot T, Maiese D, J, Olson T, Pashankar F, Rodriguez-Galindo Nguyen V, Wuebbolt D, Thomas H, Hamilton C. The PhenX Toolkit: Standard C, Shaikh F, Stark D, Frazier L, Stoneham Shehata N, Krahn M, D’Souza R. Iron Phenotype and eXposure Measures for S. Dysgerminoma In Children, Adolescent Deficiency Anaemia and Treatment Pregnancy Research. National Institute of and Young Adults: A Report From the Options. International Conference for Environmental Health Sciences Festival. Malignant Germ Cell Tumor International Healthcare and Medical Students. Durham, NC, USA, December 2016. Collaborative (Magic). 48th Congress of Dublin, Ireland, February 2017. the International Society of Paediatric Pittini A, Melamed N. Sonographic Nguyen V, Wuebbolt D, Thomas H, Shehata Oncology. Dublin, Ireland, October 2016. Characteristics of the Cervix in Women N, Krahn M, D’Souza R. Iron Deficiency with Twin Gestations at Risk of Preterm Siklenka K, Lambrot R, Xia J, Chan D, Anaemia and Treatment Options. Birth. Society for Maternal Fetal Medicine, Aarabi M, Moskovtsev SI, Librach CL, The COMET VI Meeting. Amsterdam, 37th Annual Pregnancy Meeting. Las Trasler J, Bailey J, Kimmins S. Optimizing Netherlands, November 2016. Vegas, NV, USA, January 2017. Experimental and Bioinformatic Nica A, Cesari M, Covens A, Vicus Approaches for the Analysis of Histone Qu A, Moskovtsev SI., Zhang J, Lee A, D, Kupets R, Osborne R, Gien L. Methylation in Sperm from Mice to Men. Cohen BA, Parkinson RA, Librach CL. Sentinel Lymph Nodes in Vulvar Cancer: 49th Society for the Study of Reproduction. Evaluation of Dynamic FcR Expression Management Dilemmas in Patients San Diego, CA, USA, July 2016. Patterns on Human Spermatozoa: A with Positive Nodes and Larger Tumors. Potential Novel Diagnostic Test and Ronzoni S, Keunen J, Arnold D, Smith J, Society of Gynecologic Oncology, 48th Method for Determining Optimal Timing Ryan G. Antenatal Management of Fetal Annual Meeting on Women’s Cancers. for Intrauterine Insemination (IUI). Neonatal Alloimmune Thrombocytopenia National Harbour, MD, USA, March 2017. Annual American Society of Andrology (FNAIT) and Neonatal Outcome According O’Brien M, Baczyk D, Kingdom JC. Soluble Meeting. Miami, FL, USA, April 2017. to the Category of Risk. International Factor vs. Microparticle – Mediated Society of Ultrasound in Obstetrics and Sallais J, Ermini L, Post M, Caniggia I. Endothelial Cell Dysfunction in Severe Pre- Gynaecology, 26th World Congress. Disruption of Prolyl Hydroxylase Domain eclampsia. The British Maternal and Fetal Rome, Italy, September 2016. Protein-2 (PHD2) Impairs TGFß- Medicine Society, 19th Annual Conference. dependent Sphingolipid Metabolism Satkunaratnam A. Endometrial Amsterdam, The Netherlands, March 2017. in Murine Placenta. International Hyperplasia: Pathway to Management. Philp L, Pulman K, Covens A, Vicus D, Federation of Placenta Associations. Challenges in Obstetrics and Gynaecology Kupets R, Gien LT. Feasibility and Safety Portland, OR, USA, September 2016. Conference. Kuwait, February 2017. of Same-day Discharge after Laparoscopic Salem S, Melamed N. Neonatal Outcome Satkunaratnam A. Advancing Radical Hysterectomy for Cervix Cancer. of Low-Risk Late-Preterm Twins – Are Ambulatory Procedures. Challenges Society of Gynecologic Oncology, 48th They Facing the Same Risks as Singletons? in Obstetrics and Gynaecology Annual Meeting on Women’s Cancers. Society for Maternal Fetal Medicine, Conference. Kuwait, February 2017. National Harbor, MD, USA, March 2017. 37th Annual Pregnancy Meeting. Las Sehmbi H, D’Souza R, Murphy KE, Phillips M, Malinowski AK, Dolan S, Vegas, NV, USA, January 2017. Bhatia A. Low Back Pain in Pregnancy – Ananth C, Catalano P, Hines E, Kirby R, Saini B, Zhu MY, Portnoy S, Porayette P, Investigations, Management, and the Role Klebanoff M, Mulvhill J, Simhan H, Wright Lim JM, Duan AQ, Sled J, Wald R, Windrim of Neuaxial Analgesia and Anaesthesia: R, Ramos EM, Kilpatrick L, Hendershot R, Macgowan C, Kingdom JC, Seed M. A Narrative Review. American Congress T, Maiese D, Hamilton C. The PhenX Non-invasive In Utero Measurements of of Obstetricians and Gynaecologists Toolkit: Standard Phenotype and eXposure Placental Oxygen Transport Using MRI. Meeting. San Diego, CA, USA, May 2017. Measures for Pregnancy Research. Society International Society of Ultrasound in of Toxicology 56th Annual Meeting. Selk A, Dogra N, Antanrajakumar A, Obstetrics and Gynaecology, 26th World Baltimore, MD, USA, March 2017. Sarangapani A. Vulvovaginal Education Congress on Ultrasound in Obstetrics and in North American Gynaecology Gynecology. Rome, Italy, September 2016.

ANNUAL REPORT 2016/17 111

Residency Programs. North American in Pregnancy. Scottish Undergraduate Underhill A, Kennedy V, Ion A, Greene Chapter of the International Society Obstetrics and Gynaecology Conference. S, Loutfy M, Yudin MH. Social Support for the Study of Vulvovaginal Disease. Edinburgh, United Kingdom, March 2017. and Lonliness: Are the Experiences of Chicago, IL, USA, September 2016. Mothers Living with HIV Unique? 7th Thomas H, Krahn M, Nguyen V, Wuebbolt International Workshop on HIV and Women. Sinajon P, Chitayat D, Chong K, Noor A. D, Sermer M, Silversides C, D’Souza R. Seattle, WA, USA, February 2017. Increased Nuchal Translucency and Noonan Variation in Preferences of Pregnant Women Syndrome Spectrum – A Mount Sinai with and without Cardiac Disease for Health Valiaveettil C, Caddy S, Yudin MH, Hospital Experience. 21st International States Related to the Use of Anticoagulants Benoit A, Ding E, Kaida A, de Pokomandy Conference on Prenatal Diagnosis and in Pregnancy. The COMET VI Meeting. A, Hogg RS, Loutfy M. Association of Therapy. San Diego, CA, USA, July 2017. Amsterdam, Netherlands, November 2016. Antiretroviral Use and Abnormal Uterine Bleeding in Women Living with HIV. 6th Siu S, Sermer M, Wald W, Colman J, Thurman R, Zaffar N, Sayyar P, International Workshop on HIV and Women. Silversides CK. Twenty Year Trends in Silversides C, Murphy KE, D’Souza Boston, MA, USA, February 2016, Maternal and Perinatal Complications R. Variation in Outcome Reporting in in Pregnant Women with Heart Disease. Cardiac Arrhythmias and Aortopathies Van Mieghem T, Jamaer E, Ranzini ACC 66th Annual Scientific Session & in Pregnancy. American Congress A. Aberrant Right Subclavian Artery: Expo. Washington, DC, USA, March 2017. of Obstetricians and Gynaecologists Correlation with Fetal and Neonatal Meeting. San Diego, CA, USA, May 2017. Abnormalities. 20th International Sun L, Saini B, Porayette P, Macgowan Conference on Prenatal Diagnosis and C, Sled J, Yoo SJ, Grosse-Wortmann L, Thurman R, Zaffar N, Sayyar P, Sermer M, Therapy. Berlin, Germany, July 2016. Jaeggi E, McCrindle BW, Kingdom JC, Siu S, Silversides C, D’Souza R. Labour Hickey E, Miller S, Seed M. Fetal Cerebral Profile and Outcomes in Pregnant Women Van Nguyen JM, Bouchard-Fortier G, Blood Flow and Neonatal Brain White with Cardiac Disease. Society for Maternal Ferguson SE, Covens A. How Common Matter Change in Human Fetuses with Fetal Medicine, 37th Annual Pregnancy Is the Growing Teratoma Syndrome Complex Congenital Heart Disease. Meeting. Las Vegas, NV, USA, January 2017. in Patients with Ovarian Immature International Society of Ultrasound in Teratoma? 16th Biennial Meeting of Thurman R, Zaffar N, Silversides C, Obstetrics and Gynaecology, 26th World the International Gynecologic Cancer D’Souza R. Variation in Outcome Reporting Congress on Ultrasound in Obstetrics and Society. Lisbon, Portugal, October 2016. in Cardiac Arrhythmias and Aortopathies Gynecology. Rome, Italy, September 2016. in Pregnancy. The COMET VI Meeting. Vergote I, Scambia G, O’Malley D, Van Sqapi MH, Matthews SG, Bocking A, Amsterdam, Netherlands, November 2016. Calster B, del Campo J, Meier W, Bamias A, Levitan R. Placentally Derived Serotonin in Colombo N, Wenham R, Covens A, Marth Tyagi T, Alarab M, Drutz H, Lye S, Highly Seasonally Pregnant Women. Society C, Mirza M, Kroep J, Ma H, Pickett C, Monk Shynlova O. The Effect of Local Estrogen for Reproductive Investigation, 64th Annual B. Trinova-3/Engot-Ov-2/Gog-3001: A Therapy on Extracellular Matrix Biogenesis Meeting. Orlando, FL, USA, March 2017. Randomized, Double-Blind Phase 3 Study and Remodeling in Vaginal Tissue of of Trebananib Plus Carboplatin/Paclitaxel Thomas H, Wuebbolt D, Nguyen V, Postmenopausal Women with Severe as First-Line Treatment in Advanced Murphy KE, Sermer M, D’Souza R. Pelvic Organ Prolapse. Society for Ovarian Cancer. 16th Biennial Meeting Variation in Preferences of Pregnant Reproductive Investigation, 64th Annual of the International Gynecologic Cancer Women for Outcomes Related to the Meeting. Orlando, FL, USA, March 2017. Society. Lisbon, Portugal, October 2016. Use of Anticoagulants in Pregnancy. Tyagi T, Alarab M, Leong Y, Drutz H, American Congress of Obstetricians Viau-Lapointe J, Kfouri J, D’Souza R, Rose Lye S, Shynlova O. Local Estrogen and Gynaecologists Meeting. San L, Lapinsky S. Mechanical Ventilation in Therapy Modulates the Expression of Diego, CA, USA, May 2017. Pregnant Women. International Society ECM Remodelling & Structural Genes of Obstetric Medicine Congress. Cape Thomas H, Krahn M, Nguyen V, Wuebbolt and Immune Response in Vaginal Town, South Africa, March 2017. D, Sermer M, Siversides C, D’Souza R. Tissue of Postmenopausal Women with Variation in Preferences of Pregnant Women POP. International Urogynecological Viau-Lapointe J, Kfouri J, D’Souza R, with and without Cardiac Disease for Health Association Annual Meeting. Cape Rose L, Lapinsky S. Outcome Reported States Related to the Use of Anticoagulants Town, South Africa, August 2016. in Studies on Mechanical Ventilation in

112 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY International Abstract Presentations

Critically Ill Pregnant and Postpartum Zaffar N, Bhagra C, Murphy KE, Sermer Patients: A Systematic Review. M, Ross H, D’Souza R. Pregnancy American Thoracic Society Conference. Outcomes Following Cardiac Transplant. Washington, DC, USA, May 2017. American Congress of Obstetricians and Gynaecologists Meeting. San Viau-Lapointe J, Kfouri J, Rose L, D’Souza Diego, CA, USA, May 2017. R, Lapinsky S. Development of a Core Outcome Set for Studies of Pregnant Zhang J, Schiza C, Drabovich A, Lo Women Requiring Mechanical Ventilation. K, Jarvi K, Diamandis EP, Gauthier- The COMET VI Meeting. Amsterdam, Fisher A, Moskovtsev SI, Librach CL. Netherlands, November 2016. Validation of Testis Expressed 101 (TEX101) Protein as a Potential Capture Wuebbolt D, Nguyen V, Thomas H, Bui Antigen in Live Spermatozoa Sorting. E, Murphy KE, D’Souza R. Preferences Annual American Society of Andrology of Pregnant Women with and without Meeting. Miami, FL, USA, April 2017. Epilepsy for Health States Related to the Use of Anti-epileptic Medications Zhu MY, Duan AQ, Saini B, Lim JM, Milligan in Pregnancy. American Congress N, Windrim R, Macgowan C, Kingdom of Obstetricians and Gynaecologists JC, Seed M. The Relative Utility of Lowest Meeting. San Diego, CA, USA, May 2017. versus Latest CPR for Identifying Late Onset IUGR and Predicting Requirement Wuebbolt D, Nguyen V, Thomas H, Bui for Admission to NICU. International E, Krahn M, D’Souza R. Preferences Society of Ultrasound in Obstetrics and of Pregnant Women with and without Gynaecology, 26th World Congress on Epilepsy for Health States Related to Ultrasound in Obstetrics and Gynecology. the Use of Anti-epileptic Medications Rome, Italy, September 2016. in Pregnancy. International Conference for Healthcare and Medical Students. Zwayne N, Allen L, Kives S. A Dublin, Ireland, February 2017. Retrospective Look at the Use and Safety of Tranexamic Acid in an Wuebbolt D, Nguyen V, Thomas H, Bui Adolescent Population. North American E, Krahn M, D’Souza R. Preferences Society of Pediatric and Adolescent of Pregnant Women with and without Gynaecology, 31st Annual Clinical Epilepsy for Health States Related to Meeting. Chicago, IL, USA, April 2017. the Use of Anti-epileptic Medications in Pregnancy. The COMET VI Meeting. Amsterdam, Netherlands, November 2016.

Yousuf AA, Satkunaratnam A, Frecker H, Shore EM. The Development of a Retroperitoneal Dissection Model. Journal of Minimally Invasive Gynecology. American Association of Gynecologic Laparoscopists. Orlando, FL, USA, November 2016.

Yudin MH, Beatty C, MacGillivray J. High Rates of Sexual Trauma History and Food Insecurity among HIV-positive Pregnant Women in Toronto, Canada. 7th International Workshop on HIV and Women. Seattle, WA, USA, February 2017.

ANNUAL REPORT 2016/17 113 NATIONAL ABSTRACT PRESENTATIONS

Alayed N, Okun N, Chong K, Noor A, Meeting. Montreal, QC, Canada, May 2017. Tuo J, Chan CC, Friedlander M, van der Chitayat D, Kolomietz E. Chromosomal Kooy D, Shoichet M, Nagy A. Combined Chow T, Whiteley J, Nagy A, Rogers Microarray as a First Tier Test Following Cell and Gene Therapy towards the I. Directed Differentiated of Human Diagnostic Prenatal Procedures, The Treatment of Age-related Macular CD34+ Cord Blood Induced Pluripotent Toronto Mount Sinai Hospital Experience. Degeneration. 2016 Till and McCulloch Stem Cells to Multipotent Nephron Canadian National Perinatal Research Meetings. Whistler, BC, October 2016. Progenitors. Till and McCulloch Meetings. Meeting. Banff, AB, Canada, February 2016. Whistler, BC, Canada, October 2016. Harding J, Vintersten K, Yang H, Lye Baker J, Shuman C, Chitayat D, Wasim S, Nagy A. Designer Cells: Evading Chow T, Nagy A, Rogers I. Directed S, Okun N, Keunen J, Hofstedter R, Immune Recognition and Rejection Differentiated of Human CD34+ Cord Silver R. Informed Decision-Making in without Dangerous Immunosuppressive Blood Induced Pluripotent Stem Cells the Context of Prenatal Chromosomal Drugs. Till and McCulloch Meetings. to Multipotent Nephron Progenitors. Microarray. Canadian Association of Genetic Whistler, BC, October 2016. Till and McCulloch Meetings. Counsellors, Annual Education Conference. Whistler, BC, October 2016. Helpman L, Perri T, Hag-Yahia N, Lavee Montreal, QC, Canada, November 2016. N, Kalfon S,Chariski HA, Kadan Y,Korach Ferguson SE, Gotlieb WH, Gien LT, Giede Balogun K, Guzman Lenis M, Papp E, Loutfy J, Covens A, Gien LT. Impact of Adjuvant C, Samouelian V, Steed H, Renkosinskia M, Yudin MH, MacGillivray J, Walmsley Treatment on High-risk Early-stage B, Abitbolg J, Warkush T, Lei T, Martin S, Silverman M, Serghides L. Elevated Endometrial Cancer: A Retrospective V, Panzarella T, Covens A, Bernardini Estradiol Levels in HIV-positive Pregnant 3-center Study. Society of Obstetricians MQ. GOC2: A Multi-centre Prospective Women on Protease Inhibitor-based and Gynaecologists of Canada, 73rd Trial Comparing Open, Laparoscopic and Regimens: An Association with Fetal Growth Annual Clinical and Scientific Conference. Robotic Surgical Outcomes in Women with Restriction. Canadian Conference on HIV/ Ottawa, ON, Canada, June 2017. Endometrial Cancer. Part B: Patient- AIDS Research, Annual Clinical Meeting. reported Outcomes. Society of Obstetricians Kennedy VL, Underhill A, Ion A, Loutfy April 2017, Montreal, QC, Canada. and Gynaecologists of Canada, 73rd M, Greene S, Yudin MH. Demographic Bernardini MQ, Gien LT, Giede C, Annual Clinical and Scientific Conference. Differences with Impact: Understanding Samouelian V, Steede H, Ferguson SE, Ottawa, ON, Canada, June 2017. how Mothers Living with HIV Differ from Renkosinskif B, Abitbolg J, Warkush T, Lei their HIV-negative Peers. Canadian Furmli H, Seeto R, Hewko S, Bocking T, Martin V, Covens A, Panzarella T, Gotlieb Conference on HIV/AIDS Research A, Murphy KE. Mental Health WH. GOC2: A Multi-centre Prospective (CAHR), Annual Clinical Meeting. Outcomes in Assisted versus Natural Trial Comparing Open, Laparoscopic and April 2017, Montreal, QC, Canada. Conception: A Prospective Cohort Robotic Surgical Outcomes in Women with Study. Society of Obstetricians and Khan S, Kennedy VL, Loutfy M, Yudin MH, Endometrial Cancer. Part A: Peri-operative Gynaecologists of Canada, 73rd Annual Read S, Bitnun A. Infant Feeding in HIV Outcomes. Society of Obstetricians and Clinical and Scientific Conference. in Canada: Clinical and Research Priority Gynaecologists of Canada, 73rd Annual Ottawa, ON, Canada, June 2017. Meeting. Canadian Conference on HIV/ Clinical and Scientific Conference. AIDS Research, Annual Clinical Meeting. Ottawa, ON, Canada, June 2017. Gojska N, McCuaig J, Demsky R, Volenik Montreal, QC, Canada, April 2017. A, Kim R, Shuman C, Chitayat D, Maganti Bongolan TB, Chow T, Whiteley J, Keating M, Ferguson S, Randall Armel S. GC-307 Khan S, Kennedy VL, Loutfy M, Yudin MH, A, Rogers I. Cell Source Impact on Casting a Wider Net: A Comparison Read S, Bitnun A. “It’s Not Easy”: Infant Induced Pluripotent Stem Cells (iPSCs) of the Experiences and Preferences Feeding in HIV Context in a Resource-rich Production and Differentiation. Till of Patients Pursuing BRCA1/2 and Setting – Strengths, Challenges and and McCulloch Meetings. Whistler, Multi-gene Panel Testing. Canadian Choices. Canadian Conference on HIV/ BC, Canada, October 2016. Association of Genetic Counsellors AIDS Research, Annual Clinical Meeting. Chow T, Whiteley J, Rogers I. Generation and Annual Education Conference. Montreal, QC, Canada, April 2017. and Directed Differentiation of Cord Blood Montreal, QC, Canada, November 2016. Kibschull M, Nguyen T, Chow C, Lye S, and Uterine Induced Pluripotent Stem Hacibekiroglu S, Michael IP, Mitrousis Drutz H, Alarab M, Rogers I, Shynlova Cells to Nephron Progenitors. Canadian N, Vawda R, Ballios B, Westenskow P, O. Urine-derived Induced Pluripotent Society of Nephrology, Annual General

114 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY NATIONAL ABSTRACT PRESENTATIONS

Stem Cells from Patients with Stress Lennox G, Zigras T, Covens A. The Rectus Vancouver, BC, Canada, October 2016. Urinary Incontinence: A Source for Abdominis Myoperitoneal Flap for Vaginal Massumi M, Liang Q, Nagy K, Harding Derivation of Autologous Fibroblasts for Reconstruction. 38th Annual General J, Nagy A. Designer Tissue: Generating Treatment of Pelvic Floor Disorders (Pilot Meeting, Society of Gynecologic Oncology a Dormant and Artificial Ectopic Site Project). International Urogynecological of Canada and the Annual General for Transplantation of Pancreatic Association 42th Annual Meeting. Meeting Program Planning Committee. β-cells. Till and McCulloch Meetings. Vancouver, Canada, June 2017. Ottawa, ON, Canada, June 2017. Whistler, BC, October 2016. King C, Sheehan C, Aggarwal A, Allen Li A, Lee P. The Effect of Medical McDermott CD. A Cost Utility Analysis L, Spitzer R. Use of Audio Computer- Consultation on Patients’ Concerns about of Non-Surgical Treatments for assisted Self-interviews (ACASI) to Vaginal Mesh Use in Pelvic Reconstructive the Management of Stress Urinary Gather Information on Risk Behaviours Surgery. Society of Obstetricians and Incontinence. International Urogynecology in a Referral Population of Pregnant Gynaecologists of Canada, 73rd Annual Association, Annual Clinical Meeting. Adolescents. Society of Obstetricians Clinical and Scientific Conference. Vancouver, BC, Canada, June 2017. and Gynaecologists of Canada, 73rd Ottawa, ON, Canada, June 2017. Annual Clinical and Scientific Conference. Monetti C, Liang Q, Neely E, Shutova Liang Q, Monetti C, Shutova M, Nagy Ottawa, ON, Canada, June 2017. M, Nagy A. Designer Cells: Doxycycline A. Fail-safe Cell Design for Cell Controlled Proliferation. Till and McCulloch Landon E, Selk A. Understanding the Therapies. 2016 Till and McCulloch Meetings. Whistler, BC, October 2016. Experiences of Parental Leave during Meetings. Whistler, BC, October 2016. Obstetrics and Gynaecology Training in Nashid N, Khan S, Loutfy M, MacGillivray Louridas M, Grantcharov TP, Seeman N, Canada. Society of Obstetricians and J, Yudin MH, Campbell D, Barrozzino T, Iancu AM, Steele D, Ahmed N, Shore Gynaecologists of Canada, 73rd Annual Baqui M, Kennedy VL, Read S, Bitnun EM. Modelling the Learning Curves of Clinical and Scientific Conference. A. Breastfeeding in the HIV Context Incoming Surgical Trainees. Society of Ottawa, ON, Canada, June 2017. in Canada – Better Out in the Open. Obstetricians and Gynaecologists of Canadian Conference on HIV/AIDS Lee A, May T. Investigating the Impact of Canada. Ottawa, ON, Canada, June 2017. Research, Annual Clinical Meeting. Interval from Primary Cytoreductive Surgery Luketic L, Allen L, Bernardini MQ, April 2017, Montreal, QC, Canada. to Initiation of Adjuvant Chemotherapy Jacobson M, Sobel M. Best of Three: Risk- in Advanced Epithelial Ovarian Cancer: A Neely E, Nagy A. Development of Reducing Salpingo-Oophorectomy in BRCA Multi-Institutional Study of 711 Patients. Local Acting Biologics and Novel Mutation Carriers. Society of Obstetricians 38th Annual General Meeting, Society of Delivery to Treat Rheumatoid Arthritis. and Gynaecologists of Canada, 73rd Gynecologic Oncology of Canada and the 2016 Till and McCulloch Meetings. Annual Clinical and Scientific Conference. Annual General Meeting Program Planning Whistler, BC, October 2016. Ottawa, ON, Canada, June 2017. Committee. Ottawa, ON, Canada, June 2017. Ngan T, Papillon-Smith, Murji Madjunkova S, Antes R, Kuznyetsov Lee AY, Brown T, Kollara A, May T. Impact A. Vasopressin in Gynecological V, Librach CL. Clinical Validation of of Wound Healing on Ovarian Cancer Procedures. Society of Obstetricians and NGS in PGD-PGS for Chromosomal Progression and Sensitivity to Platinum- Gynaecologists of Canada, 73rd Annual Rearrangements. American Society of based Agents: A Pilot Study Using a Clinical and Scientific Conference. Human Genetics, 66th Annual Meeting. Syngeneic Orthotopic Mouse Model. Ottawa, ON, Canada, June 2017. Vancouver, BC, Canada, October 2016. 38th Annual General Meeting, Society of Nica A, Cesari M, Covens A, Vicus Gynecologic Oncology of Canada and the Martin N, Nimmo G, Watkins N, Keunen D, Kupets R, Osborne R, Gien L. Annual General Meeting Program Planning J, Kolomietz E, Roifman M. Case Report: Sentinel Lymph Nodes in Vulvar Cancer: Committee. Ottawa, ON, Canada, June 2017. Prenatal Diagnosis of X-linked Optiz Management Dilemmas in Patients G/BBB Syndrome by Chromosomal Lee P, Li A. Patients’ Concerns with Positive Nodes and Larger Microarray in a Fetus Presenting with About Vaginal Mesh Use in Pelvic Tumors. Society of Obstetricians and Fetal Hydrops, Increased Nuchal Fold and Reconstructive Surgery. International Gynaecologists of Canada, 73rd Annual Absent Nasal Bone. American Society of Urogynecology Association Annual Meeting. Clinical and Scientific Conference. Human Genetics, 66th Annual Meeting. Vancouver, BC, Canada, June 2017.

ANNUAL REPORT 2016/17 115

Ottawa, ON, Canada, June 2017. Fibroid Treatment. Society of Obstetricians Urogynecological Association, 42th Annual and Gynaecologists of Canada, 73rd Meeting. Vancouver, Canada, June 2017. Nimmo G, Staines A, Shannon P, Annual Clinical and Scientific Conference. Keating S, Mirzaa G, Chitayat D. Fetal Vainder M, Kives S, Yudin MH. Rates Ottawa, ON, Canada, June 2017. Neuronal Migration Defects and Severe of Gonorrhea and Chlamydia Screening Cardiac Abnormalities Associated with Ronzoni S, Keunen J, Shah PS, Windrim among Pregnant Women Presenting for a de Novo Pathogenic Mutation in the R, Seaward G, Ryan G. Antenatal Prenatal Care. Society of Obstetricians PIK3R2 Gene. American Society of Management of Fetal/Neonatal Alloimmune and Gynaecologists of Canada, 73rd Human Genetics, 66th Annual Meeting. Thrombocytopenia: Should We Completely Annual Clinical and Scientific Conference. Vancouver, BC, Canada, October 2016. Abandon Invasive Procedures? The 4th Ottawa, ON, Canada, June 2017. Annual Canadian National Perinatal Osborne R, Mohan N, Covens A, Whiteley J, Chow T, Kaths M, Hamar Research Society Meeting. Montebello, Bouchard-Fortier G. Management M, Selzner M, Rogers I. Murine and QC, Canada, February 2017. of Low Risk GTN with Bi-weekly Porcine Extracellular Matrices as a Dactinomycin. Society of Obstetricians Satkunaratnam A, Kives S, Robertson Scaffold for Three-dimensional Tissue and Gynaecologists of Canada, 73rd D. Minimal Access Surgery in Maximum Culture. Till and McCulloch Meetings. Annual Clinical and Scientific Conference. BMI Patients. Society of Obstetricians Whistler, BC, Canada, October 2016. Ottawa, ON, Canada, June 2017. and Gynaecologists of Canada, 73rd Wuebbolt D, Nguyen V, Thomas H, Bui Annual Clinical and Scientific Conference. Philp L, Pulman K, Covens A, Vicus E, Murphy KE, D’Souza R. Preferences Ottawa, ON, Canada, June 2017. D, Kupets R, Gien L. Feasibility and of Pregnant Women with and without Safety of Same-day Discharge after Shore EM, Lichtman AS, Goff B, Parker Epilepsy for Health States Related to Laparoscopic Radical Hysterectomy for W, Lefebvre GG, Chiang A, Lenihan Jr the Use of Anti-Epileptic Medications in Cervix Cancer. Society of Obstetricians J, Schreuder HWR, Mehra N. Improving Pregnancy. Society for Medical Decision and Gynaecologists of Canada, 73rd Cognitive Surgical Knowledge in OBGYN Making, North American Meeting. Annual Clinical and Scientific Conference. Residents Using an Interactive Computer- Vancouver, BC, Canada, October 2016. Ottawa, ON, Canada, June 2017. Based Laparoscopic Hysterectomy Yang H, Rogers I, Nagy A. Development Trainer. Society of Obstetricians and Phillips M, Malinowski AK, Siobhan D, of Mice with Personalized Immune Gynaecologists of Canada, 73rd Annual Ananth C, Catalano P, Hines E, Kirby Systems Using Thymic Epithelial Clinical and Scientific Conference. R, Klebanoff M, Mulvhill J, Simhan H, Progenitors Differentiated from Ottawa, ON, Canada, June 2017. Wright R, Ramos E. M, Kilpatrick L, iPSCs. Till and McCulloch Meetings. Hendershot T, Maiese D, Hamilton C. Shutova M, Liang Q, Monetti C, Nagy A. Whistler, BC, October 2016. The PhenX Toolkit: Standard Phenotype Designer Cells: Modelling how Fail-safe Yeung G, Satkunaratnam A. Cost- and eXposure Measures for Pregnancy is a “Fail-safe” Cell. Till and McCulloch analysis of Surgical Treatment for Research. American Society of Human Meetings. Whistler, BC, October 2016. Endometriosis: Helium Gas Plasma vs. Genetics, 66th Annual Meeting. Steckham K, Murji A, Kingdom JC, Laser Laparoscopy. Canadian Society Vancouver, BC, Canada, October 2016. Windrim R, Allen L. Impact of Cell Saver on for Advancement in Gynecologic Philp L, Pulman K, Covens A, Vicus D, Allogenic Transfusion Rates at Caesarean Endoscopy, 2nd Annual Meeting. Kupets R, Gien LT. Feasibility and Safety Delivery in Women with Abnormal Invasive Montreal, QC, Canada, September 2017. of Same-day Discharge after Laparoscopic Placentation. Society of Obstetricians Yeung G, Satkunaratnam A. Helium Radical Hysterectomy for Cervix Cancer. and Gynaecologists of Canada, 73rd Gas Plasma Energy: Treatment of 38th Annual General Meeting, Society of Annual Clinical and Scientific Conference. Endometriosis with J-Plasma. Canadian Gynecologic Oncology of Canada and the Ottawa, ON, Canada, June 2017. Society for Advancement in Gynecologic Annual General Meeting Program Planning Tyagi T, Alarab M, Lye S, Shynlova O. Endoscopy, 2nd Annual Meeting. Committee. Ottawa, ON, Canada, June 2017. The Expression of Major ECM Proteins – Montreal, QC, Canada, September 2017. Po L, Kung R, Lee P. Factors Influencing Collagen and Elastin – is Enhanced by Yousuf AA, Frecker H, Satkunaratnam Patients’ Willingness to Undergo Local Estrogen Therapy in Postmenopausal A, Shore EM. The Development Morcellation in Minimally Invasive Surgical Women with POP. International

116 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY National Abstract Presentations

of a Retroperitoneal Dissection Model. Society of Obstetricians and Gynaecologists of Canada, 73rd Annual Clinical and Scientific Conference. Ottawa, ON, Canada, June 2017.

Yudin MH, Beatty C, MacGillivray SJ. The Importance of Trauma-informed Care Provision for HIV-positive Pregnant Women. Canadian Conference on HIV/ AIDS Research, Annu l Clinical Meeting. April 2017, Montreal, QC, Canada.

Zakhari A, Papillon-Smith J, Solnik J, Murji A. Minimizing Ovarian Damage During Endometrioma Surgery. Society of Obstetricians and Gynaecologists of Canada, 73rd Annual Clinical and Scientific Conference. Ottawa, ON, Canada, June 2017.

ANNUAL REPORT 2016/17 117 LOCAL ABSTRACT PRESENTATIONS

Alayed N, Chitayat D, Okun N, Chong Toronto, ON, Canada, May 2016. Insufficiency and Fetal Hypoxia in Mice. K, Noor A, Kolomietz E. Chromosomal 5th International Fetal Growth Meeting. Bongolan TB, Chow T, Whiteley J, Microarray as a First Tier Test Following Toronto, ON, Canada, November 2016. Moamed A, Kaths M, Hamar M, Selzner Diagnostic Prenatal Procedures, The M, Rogers I. Kidney Regeneration Carnevale A, Jarvi K, Shuman C, Toronto Mount Sinai Hospital Experience. Using Induced Pluripotent Stem Cells Yee S, Chitayat D, Morel C, Murphy Department of Obstetrics & Gynaecology, and Extracellular Matrix Scaffolds. J. Psychosocial Impacts Related to University of Toronto, 33rd Annual Research Department of Physiology’s 37th Annual Receiving a Diagnosis of Klinefelter Day. Toronto, ON, Canada, May 2016. Research Day, University of Toronto. Syndrome in Adulthood. Division of Alayed N, Chitayat D, Okun N, Chong Toronto, ON, Canada, May 2017. Clinical and Metabolic Genetics, Hospital K, Noor A, Kolomietz E. Chromosomal for Sick Children, Annual Research Day. Bongolan TB, Chow T, Whiteley J, Mohamed Microarray as a First Tier Test Following Toronto, ON, Canada, April 2016. A, Kaths M, Hamar M, Selzner M, Rogers Diagnostic Prenatal Procedures, The I. Differentiating Induced Pluripotent Chandrasekaran N, De Souza L, Storm Toronto Mount Sinai Hospital Experience. Stem Cells into Renal Progenitors for S, Hashim S, Walfischa A,Berger H. Division of Clinical and Metabolic Genetics Reseeding on Decellularized Scaffolds The Impact of Video Based Activity Annual Research Day, Hospital for Sick of the Porcine Kidney. Department of Platform on Management of Gestational Children. Toronto, ON, Canada, April 2016. Obstetrics & Gynaecology, University Diabetes – A Randomized Controlled Audette MC, Wright E, Ye XY, Keating of Toronto, 34th Annual Research Day. Trial. University of Toronto Research S, Hoffman B, Shah PS, Kingdom JC. Toronto, ON, Canada, April 2017. Day. Toronto, ON, Canada, April 2017. Screening Healthy Nulliparous Women for Boros-Rausch A, Ngyugen L, Chow Chow T, Whiteley J, Nagy A, Rogers I. Placental Disease in the Second Trimester. T, Whiteley J, Rogers I. iPSC from Kidney in a Dish: Making Kidney Organoids 5th International Fetal Growth Meeting. Umbilical Cord Blood and Umbilical from Embryonic Stem Cells – Derived Toronto, ON, Canada, November 2016. Cord Tissue. Lunenfeld-Tanenbaum Renal Progenitors. Department of Audette MC, Wright E, Ye XY, Keating S, Research Institute, Sinai Health System. Obstetrics & Gynaecology, University Hoffman B, Lye S, Shah PS, Kingdom JC. Toronto, ON, Canada, July 2016. of Toronto, 34th Annual Research Day. Screening Healthy Nulliparous Women for Toronto, ON, Canada, April 2017. Brachtchenko J, Kan-ool L, Antes R, Placental Disease in the Second Trimester. Kuznyetsov V, Galewicz-Sojecki A, Legro Chow T, Whiteley J, Nagy A, Rogers I. Department of Obstetrics & Gynaecology, N, Gauthier-Fisher A, Moskovtsev SI, Making Kidney Organoids from Renal University of Toronto, 34th Annual Research Madjunkova S, Librach CL. Impact of Progenitors Differentiated from Pluripotent Day. Toronto, ON, Canada, April 2017. Preimplantation Genetic Screening on Stem Cells. Department of Physiology’s Baillargeon A, Defer M, Zohni K, Naeini M, the Rate of Ultrasound-detected FIrst 37th Annual Research Day, University of Gauthier-Fisher A, Sharma P, Librach CL. Trimester Fetal Abnormalities. Department Toronto. Toronto, ON, Canada, May 2017. Neuronal Growth Factors in Follicular Fluid of Obstetrics & Gynaecology, University Duan AQ, Keunen J, Portnoy S, Zhu and Their Correlation with Female Infertility. of Toronto, 34th Annual Research Day. MY, Porayette P, Macgowan C, Seed M. Department of Obstetrics & Gynaecology, Toronto, ON, Canada, April 2017. Preliminary Investigation of the Utility University of Toronto, 34th Annual Research Bussiere-Cote S, Berger H, Park A, of MRI for Measuring the Hematocrit Day. Toronto, ON, Canada, April 2017. Ray JG. Twice-daily vs. Four Times Daily in Fetal Anemia. Department of Balogun K, Kala S, Siou K, Papp E, Glucose Testing in Women with Gestational Obstetrics & Gynaecology, University Mohammadi H, Guzman M, Lu J, Loutfy M, Diabetes Mellitus: Pilot Study. Department of Toronto, 33rd Annual Research Day. Yudin MH, Murphy KE, Walmsley S, Shah of Obstetrics & Gynaecology, University Toronto, ON, Canada, May 2016. R, MacGillivray SJ, Silverman M, Serghides of Toronto, 34th Annual Research Day. Dupré J, Lee P.Enhancing Patient L. HIV and Antiretrovirals: Understanding Toronto, ON, Canada, April 2017. Understanding of Bladder and Kidney the Mechanisms that Contribute to Cahill L, Rahman A, Zhou YQ, Hoggarth Infection Department of Obstetrics Adverse Birth Outcomes in HIV-positive J, Rennie M, Seed M, Macgowan C, & Gynaecology, University of Women – A Review of the Past 5 Years. Kingdom JC, Adamson SL, Sled JG. Toronto, 34th Annual Research Day. 5th Annual Interdisciplinary HIV Pregnancy Prolonged Pregnancy Results in Placental Toronto, ON, Canada, April 2017. Research Group (IHPREG) Conference.

118 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY LOCAL ABSTRACT PRESENTATIONS

Eckler R, Rosen A, Dunlop K, Murphy Fish E, Silver A, Librach L, Antes R, of Introducing an Evidence Based KE, D’Souza R. Prospective Validation Abromov R, Kuznyetsov V, Madjunkova S, Multidisciplinary Algorithm on the of Formulae for the Estimation of Librach CL. A Novel Method to Calculate Management of Adnexal Masses in the Intrapartum Blood Loss. Department of the Mitochondrial DNA/Nuclear DNA Ratio Pediatric Population. Department of Obstetrics & Gynaecology, University in Human Blastocysts as a Biomarker for Obstetrics & Gynaecology, University of Toronto, 34th Annual Research Day. Human Embryo Implementation Potential. of Toronto, 34th Annual Research Day. Toronto, ON, Canada, April 2017. Department of Obstetrics & Gynaecology, Toronto, ON, Canada, April 2017. University of Toronto, 34th Annual Research Fantin A, Rogers I. Developing a 3D Gotz T. Jones C. Distribution of Funded IVF Day. Toronto, ON, Canada, April 2017. Culture System Using Decullarized in Ontario: A Patient Perspective. Annual Pancreas to Support the Growth and Flatt S, Naeini M, Kenigsberg S, Wyse B, Departmental Research Day. Department Differentiation of iPSC Derived Islets. Gauthier-Fisher A, Librach CL. Optimizing of Obstetrics & Gynaecology, University Banting and Best Diabetes Centre. a Standard Procedure for the Isolation and of Toronto, 34th Annual Research Day. Toronto, ON, Canada, August 2016. Purification of Human Granulosa Cells Toronto, ON, Canada, April 2017. for Biobanking Purposes. Department Fantin A, Rogers I. Developing a 3D Gotz T, Jones C. Prioritization of Patients for of Obstetrics & Gynaecology, University Culture System Using Decullarized IVF Funding in Ontario. Canadian Fertility of Toronto, 34th Annual Research Day. Pancreas to Support the Growth and and Andrology Society Annual Meeting. Toronto, ON, Canada, April 2017. Differentiation of iPSC Derived Islets. Toronto, ON, Canada, September 2017. Queens University, Research Mentorship Fuchs-Weizman NM, Wyze BA, Gat I, Gratch Y, Szaraz P, Iqbal F, Sefton Course. Kingston, ON, Canada, April 2017. Balakier H, Kenigsberg S, Russel SJ, M, Librach CL. Blood Outgrowth Caballero J, Librach CL. Cumulus Cells’ Fantin A, Rogers I. Developing a 3D Endothelial Cells (BOEC) Developed (CCs) Transcriptome Under the Influence of Culture System Using Decullarized in Xeno-free Conditions for Ischemic Different Methods for Triggering Ovulation Pancreas to Support the Growth and Tissue Regeneration. International in Patients with a High Ovarian Reserve. Differentiation of iPSC Derived Islets. Conference on Stem Cell Engineering 2016. Department of Obstetrics & Gynaecology, Banting and Best Diabetes Centre. Toronto, ON, Canada, October 2016. University of Toronto, 34th Annual Research Toronto, ON, Canada, June 2017. Day. Toronto, ON, Canada, April 2017. Hacibekiroglu S, Michael IP, Mitrousis N, Fantin A, Whiteley J, Rogers I. Developing Yang H, Massumi M, Vawda, Ballios B, Garcia M, Zohni K, Lopez L, Glass K, a 3D Culture System Using Decullarized Westenskow P, Friedlander M, van der Kooy Gauthier-Fisher A, Librach CL. Intra- Pancreas to Support the Growth and D, Shoichet M, Nagy A. Combined Cell ovarian Injection of First Trimester Human Differentiation of iPSC Derived Islets. and Gene Therapy towards the Treatment Umbilical Cord-derived Perivascular Cells Research Training Centre, Lunenfeld- of Age-related Macular Degeneration (FTM HUCPVCs) May Have Protective Tanenbaum Research Institute, Sinai Health and Diabetic Retinopathy. Lunenfeld- Effects Against Cyclosphosphamide- System. Toronto, ON, Canada, July 2016. Tanenbaum Research Institute Scientific induced Ovarian Damage in a Rat Model: Retreat. Orillia, ON, Canada, May 2017. Fernandez S, Bruni T, Bishop L, Turuba R, Preliminary Results. Department of Olibris B, Jumah NA. Difference in Hospital Obstetrics & Gynaecology, University Hahn K, Moskovtsev SI, Baratz Length of Stay for Neonates with In-Utero of Toronto, 34th Annual Research Day. A, Glass K, Sharma P, Librach CL. Exposure to Buprenorphine, Methadone and Toronto, ON, Canada, April 2017. Clinical Management of Patients with Illicit Opioids. BORN Ontario Conference Suspected Azoospermia and Severe Gat I, Li N, Yasovich N, Antes R, Kuznyetsov 2017. Toronto, ON, Canada, April 2017. Oligozoospermia at a Single Canadian V, Zohni K, Weizman N, Librach CL. Sperm Fertility Clinic. Canadian Fertility and Fernandez S, Bruni T, Bishop L, Turuba DNA Fragmentation Index (DFI) does not Andrology Society Annual Meeting. R, Olibris B, Jumah NA. Length Correlate with Blastocyst Aneuploidy Toronto, ON, Canada, September 2016. of Stay for Neonates Exposed to Rate in Egg Donor Cycles. Department Buprenorphine versus Methadone in of Obstetrics & Gynaecology, University Hollingsworth J, Lau A, Tone A, Kollara Utero. BORN Ontario Conference 2017. of Toronto, 34th Annual Research Day. A, Allen L, Colgan T, Dube V, Rosen B, Toronto, ON, Canada, April 2017. Toronto, ON, Canada, April 2017. Murphy KJ, Greenblatt E, Feigenberg T, Virtanen C, Brown TJ. BRCA2 Modulates Goldberg H, Allen, L, Kives S. Impact

ANNUAL REPORT 2016/17 119

Inflammatory and EGRF Signaling in Human King C, Sheehan C, Aggarwal A, Analysis in Human Blastocysts Derived Fallopian Tube Epithelium. Department Allen L, Spitzer R. Use of Audio from Donor Cycles. Canadian Fertility of Obstetrics & Gynaecology, University Computer Assisted Self-interviews and Andrology Society Annual Meeting. of Toronto, 34th Annual Research Day. (ACASI) to Gather Information on Risk Toronto, ON, Canada, September 2016. Toronto, ON, Canada, April 2017. Behaviours in a Referral Population of Landon E, Selk A. Understanding Pregnant Adolescents. Department of Iqbal F, Szaraz P, Kenigsberg S, Wu J, the Experiences of Parental Leave Obstetrics & Gynaecology, University Gauthier-Fisher A, Li RK, Librach CL. during Obstetrics and Gynaecology of Toronto, 34th Annual Research Day. Human Platelet Lysate (HPL) is Optimal Training in Canada. Department of Toronto, ON, Canada, April 2017. for Expansion of First Trimester Human Obstetrics & Gynaecology, University Umbilical Cord Perivascular Cells for King C, Spitzer R, Aggarwal A, Jain L, of Toronto, 34th Annual Research Day. Regenerative Medicine Applications. Goldberg H, Allen L. Bacterial Vaginosis Toronto, ON, Canada, April 2017. Canadian Fertility and Andrology in the Pregnant Adolescent Population: Lee A, Yasovich N, Mackie P, Moskovtsev Society Annual Meeting. Toronto, Screening and Treatment in a Dedicated SI, Librach CL. Evidence of DNA Damage ON, Canada, September 2016. Adolescent Prenatal Program. Department after Density Gradient Centrifugation: Do of Obstetrics & Gynaecology, University Kamen C, Yanofsky D, Gratch Y, Katzman we Need to Individualize Sperm Selection of Toronto, 34th Annual Research Day. B, Lucato A, Szaraz P, Librach CL. Methodology for ART. Canadian Fertility Toronto, ON, Canada, April 2017. First Trimester Human Umbilical Cord and Andrology Society Annual Meeting. Perivascular Cells (FTM HUCPVCs) Kurjanowicz P, Moskovtsev SI, Librach Toronto, ON, Canada, September 2016. Maintain their Regenerative Properties CL. A Systematic Review of Investigations Lee Y, Lu L, Xu W, Kollara A, Brown TJ. when Expanded in Clinical Grade on Sperm Telomere Length and Male Impact of Surgical Stress on Advanced Xeno-free Conditions. Department of Infertility Demonstrates the Dramatic Ovarian Cancer Progression and Survival Obstetrics & Gynaecology, University Effect of Study Design Given the in Relation with Timing of Chemotherapy: of Toronto, 34th Annual Research Day. Multi-factorial Nature of the Human Bedside to Bench. Department of Toronto, ON, Canada, April 2017. Reproduction Field. Canadian Fertility Obstetrics & Gynaecology, University and Andrology Society Annual Meeting. Kenigsberg S, Dufort I, Librach CL, Sirard of Toronto, 34th Annual Research Day. Toronto, ON, Canada, September 2016. MA. Evaluation of an In Vitro Model to Toronto, ON, Canada, April 2017. Assess the Regulatory Effect of Human Kurjanowicz P, Gelis P, Moskovtsev SI, Liang Q, Monetti C, Shutova M, Nagy A. A Follicular Extracellular Vesicles on Librach CL. Outcomes of Telomere Length Leap Forward for Safety in Cell Therapies. Follicular Maturation. Canadian Fertility Assessment in Human Spermatozoa Department of Obstetrics & Gynaecology, and Andrology Society Annual Meeting. are Methodologically-dependent due University of Toronto, 34th Annual Research Toronto, ON, Canada, September 2016. to the Presence of Extrachromosomal Day. Toronto, ON, Canada, April 2017. Telomeric Repeats (ECTR). Department Kfouri J, Gundy S, Faghfoury H, of Obstetrics & Gynaecology, University Liang Q, Monetti C, Sutova MV, Neely D’Souza R. Pregnancy Outcomes in of Toronto, 34th Annual Research Day. E, Hacibekiroglu S, Yang H, Zhang P, Patients with Mitochondrial Myopathy, Toronto, ON, Canada, April 2017. Mileikovsky M, Sung HK, Nagy A. A Solution Encephalomyopathy, Lacidic Acidosis and for Cell Therapy Safety. Lunenfeld- Stroke-like Episodes (MELAS) Syndrome. Kurjanowicz P, Komosa M, Moskovtsev SI, Tanenbaum Research Institute Scientific Department of Obstetrics & Gynaecology, Librach CL. Application of the haloFISH Retreat. Orillia, ON, Canada, May 2017. University of Toronto, 34th Annual Research Assay to Distinguish Chromosomal (Chr) Day. Toronto, ON, Canada, April 2017. and Extrachromosomal (EC) Telomeric DNA Librach J, Moolla L, Siddiqui F, Gauthier- Populations in the Human Sperm Genome. Fisher A, Madjunkova S, Gallagher Khan S, Kennedy L, Loutfy M, Read S, Department of Obstetrics & Gynaecology, D, Librach CL. Characterization of Yudin MH, Bitnun A. Infant Feeding Clinical University of Toronto, 34th Annual Research Human Umbilical Cord Perivascular Resources – A National Perspective. 5th Day. Toronto, ON, Canada, April 2017. Cell (HUCPVC)–derived Schwann Cells. Annual Interdisciplinary HIV Pregnancy Department of Obstetrics & Gynaecology, Research Group (IHPREG) Conference. Kuznyetsov V, Antes R, Bashar S, University of Toronto, 34th Annual Research Toronto, ON, Canada, May 2016. Ibarrientos Z, Motamedi G, Sojecki A, Day. Toronto, ON, Canada, April 2017. Madjunkova S, Librach CL. Aneuploidy

120 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Local Abstract Presentations

Liu B, Lee P. Examining the Forgetting Medications during Pregnancy and Third Progesterone Receptor Modulators Curve and How it Affects Surgical Trimester Uteroplacental Hemodynamics. (SPRMs) for Uterine Fibroids: A Skills Education. Department of 45th Annual APOG Meeting. Toronto, Cochrane Meta-Analysis. Department Obstetrics & Gynaecology, University ON, Canada, December 2016. of Obstetrics & Gynaecology, University of Toronto, 34th Annual Research Day. of Toronto, 34th Annual Research Day. Mei Lim J, Muthusami P, Madathil S, Yuan Toronto, ON, Canada, April 2017. Toronto, ON, Canada, April 2017. Zhu M, Saini B, Porayette P, Chau V, Portnoy Lo CD, Kennedy VL, Shapiro HM, Yudin S, Macgowan CK, Sled JG, Kingdom JC, Neely E, Nagy A. Development of Local MH, Loutfy M. Access to Fertility Services Seed M, Miller S. Cerebral Oxygen Delivery, Acting Biologics for Combined Cell and in Canada for HIV-positive Individuals Brain Growth and White Matter Maturation Gene Therapy to Treat Rheumatoid Arthritis. and Couples: A Comparison Between are Reduced in Congenital Heart Disease. Institute of Medical Science Scientific 2007 and 2014. Canadian Fertility and 5th International Fetal Growth Meeting. Day. Toronto, ON, Canada, May 2017. Andrology Society Annual Meeting. Toronto, ON, Canada, November 2016. Neely E, Nagy A. Development of Local September 2016, Toronto, ON, Canada. Michael A, Kung R, Bodley J, Gagnon L, Acting Biologics for Combined Cell and Lye K, Lipton N, Mackie P, Iqbal F, Szaraz P, Lee P. A Novel Approach to Post-operative Gene Therapy to Treat Rheumatoid Arthritis. Kenigsberg S, Gauthier-Fisher A, Librach Pain Management in Vaginal Surgery: Department of Obstetrics & Gynaecology, CL. Extracellular Vesicles Derived from Bupivacaine use in Vaginal Packing. University of Toronto, 34th Annual Research First Trimester Umbilical Cord Perivascular Department of Obstetrics & Gynaecology, Day. Toronto, ON, Canada, April 2017. Cells: A Potential Non-cell Source for University of Toronto, 34th Annual Research Nguemo Djiometio J, Yudin MH, Schiff Regenerative Therapy. Canadian Fertility Day. Toronto, ON, Canada, April 2017. R, Kristman V, Antoniou T, Kennedy L, and Andrology Society Annual Meeting. Mohamed A, Chow T, Whiteley J, Bongolan Loutfy M. Understanding the Fertility Toronto, ON, Canada, September 2016. T, Rogers I. Characterizing and Generating Desires and Intentions among HIV-positive MacGillivray J, Yudin MH. Culturally Aware Clinically Induced Pluripotent Stem Cells Men Living in Ontario, Canada: Survey and Trauma-informed: Tools for Fostering (iPSCs) from Human Umbilical Cord Instrument Development and Validation. Resilience in Clinical Care Received. 5th MSCs using Episomal 5 Reprogramming. 5th Annual Interdisciplinary HIV Pregnancy Annual Interdisciplinary HIV Pregnancy Department of Physiology’s 37th Annual Research Group (IHPREG) Conference. Research Group (IHPREG) Conference. Research Day, University of Toronto. Toronto, ON, Canada, May 2016. Toronto, ON, Canada, May 2016. Toronto, ON, Canada, May 2017. Nguygen V, Wuebbolt D, Thomas H, Murphy Mackie P, Alfred S, Bao B, Filice M, Mohamed A, Chow T, Whiteley J, KE, D’Souza R. Iron Deficiency Anaemia Harmandayan T, Shlush E, Balakier Bongolan T, Rogers I. Generation and in Pregnancy and Treatment Options: H, Moskovtsev SI, Librach CL. Next Characterization of Induced Pluripotent A Patient-preferred Study. Department Generation Sequencing to Assess Stem Cells (iPSCs) from Human Umbilical of Obstetrics & Gynaecology, University Ploidy Status of Single Sperm: A New Cord Mesenchymal Stromal Cells using of Toronto, 34th Annual Research Day. Tool for Validating Putative Markers Episomal 5 Reprogramming. Department Toronto, ON, Canada, April 2017. of Sperm Quality. Canadian Fertility of Obstetrics & Gynaecology, University Ouyang B, Li LDX, Mount J, Jamal A., and Andrology Society Annual Meeting. of Toronto, 34th Annual Research Day. Berry L, Simone M, Tai RWM. Incidence Toronto, ON, Canada, September 2016. Toronto, ON, Canada, April 2017. and Characteristics Needlestick Injuries Madjunkova S, Antes R, Kuznyetsov V, Moolla L, Gallagher D, Siddiqui F, Among Medical Trainees at a Community Librach CL. Direct Comparison of NGS Thomason L, Gauthier-Fisher A, Stefanovic Teaching Hospital. Michael Garraon with aCGH Preimplantation Genetics B, McLaurin J, Librach CL. Combined Hospital Research and Innovation Day. Screening for Chromosomal Abnormalities Cell and Pharmaceutical Therapy for Toronto, ON, Canada, June 2017. in Human Embryos. Canadian Fertility Alzheimer’s Disease. Department of Papillon-Smith J, Sobel M, Niles K, Solnik and Andrology Society Annual Meeting. Obstetrics & Gynaecology, University J, Murji A. Surgical Management of Toronto, ON, Canada, September 2016. of Toronto, 34th Annual Research Day. Algorithm for Caesarean Scar Pregnancy. Toronto, ON, Canada, April 2017. McLean K, Shea A, Dalfen A, Murphy Department of Obstetrics & Gynaecology, KE. The Use of Antenatal Antidepressant Murji A, Chow T, Sobel M. Selective University of Toronto, 34th Annual Research

ANNUAL REPORT 2016/17 121

Day. Toronto, ON, Canada, April 2017. JG, Wald R, Macgowan CK, Kingdom JC, Stem Cell Engineering 2016. Toronto, Seed M. Quantifying Placental Oxygen ON, Canada, October 2016. QiDuan A, Anastasiadis C, Ryan G, Transport and Consumption Using Porayette P, Saini B, Sled JG, Macgowan Szaraz P, Lucato A, Iqbal F, Librach M, Li SH, CK, Seed M. Preliminary Investigation MRI. 5th International Fetal Gauthier-Fisher A, Li RK, Librach CL. First of the Utility of MRI for Measuring Growth Meeting. Toronto, ON, Trimester Cord Perivascular Cells Exhibit the Hematocrit in Fetal Anemia. 5th Canada, November 2016. MMP-mediated Invasion Post Injury In Vitro International Fetal Growth Meeting. and Superior In-vivo Tissue Remodelling Shathasivam P, Kollara A, Spybey T, Park S, Toronto, ON, Canada, November 2016. Post Myocardial Infarct. Canadian Fertility Clarke B, Ringuette MJ, Brown TJ. VEPH1 and Andrology Society Annual Meeting. Qu A, Moskovtsev SI, Zhang J, Lee A, Expression Decreases Vascularization in Toronto, ON, Canada, September 2016. Cohen BA, Parkinson RA, Librach CL. Ovarian Cancer Xenografts and Inhibits Evaluation of Dynamic FcR Expression VEGFA and IL8 Expression through Tai M, Bordin J, Wilms E, Lee S, Patterns on Human Spermatozoa: A Novel Inhibitation of AKT Activation. Department Cram J. Can Mother Education Method that may Help Determine Optimal of Obstetrics & Gynaecology, University During Labour Reduce the Incidence Timing of Intrauterine Insemination. of Toronto, 34th Annual Research Day. of Birth Trauma? Michael Garron Department of Obstetrics & Gynaecology, Toronto, ON, Canada, April 2017. Hospital Research and Innovation Day. University of Toronto, 34th Annual Research Toronto, ON, Canada, June 2017. Sheinis M, Selk A. Development of an Day. Toronto, ON, Canada, April 2017. Adult Vulvar Lichen Sclerosus Severity Tan L, Krichesky L, Casper R, Greenblatt Rabinovich D, Szaraz P, Gratch Y, Score – A Delphi Consensus Exercise. E, Gysler M, Hannam T, Karnis M, Laskin Katzman B, Lucato A, Gauthier-Fisher Department of Obstetrics & Gynaecology, C, Sierra S, Librach CL, Sharma P. A, Librach CL. Progesterone Enhances University of Toronto, 34th Annual Research Retrospective Analysis of the Efficacy of the Immunoprivileged Properties of Day. Toronto, ON, Canada, April 2017. ART and Reproductive Outcomes in Females First Trimester Human Umbilical Cord with Fragile X Associated Primary and Sojecki A, Antes R, Balakier H, Motamedi Perivascular Cells (FTM HUCPVCs). Ovarian Insufficiency. Canadian Fertility G, Kuznyetsov V, Madjunkova S, Librach Department of Obstetrics & Gynaecology, and Andrology Society Annual Meeting. CL Comparisons of Morphokinetics University of Toronto, 34th Annual Research Toronto, ON, Canada, September 2016. and Multinucleation at the 2-cell Day. Toronto, ON, Canada, April 2017. Stage between Aneuploid and Euploid Thomas H, Wuebbolt D, Nguyen V, Murphy Sagi Y, Maxwell C, D’Souza R, Snelgrove Human Embryos. Canadian Fertility KE, Sermer M, D’Souza R. Variation J, Vernon J. Wound Disruption Following and Andrology Society Annual Meeting. in Preferences of Pregnant Women Caesarean Delivery in Women with Toronto, ON, Canada, September 2016. with and without Cardiac Disease for Class III Obesity, A Retrospective Health States Related to the Use of Steckham K, Windrim R, Kingdom JC, Case Control Study. Department of Anticoagulation in Pregnancy. Department Ryan G, Carvalho J, Murji A, Allen Obstetrics & Gynaecology, University of Obstetrics & Gynaecology, University L. Impact of Cell Saver on Allogenic of Toronto, 34th Annual Research Day. of Toronto, 34th Annual Research Day. Transfusion Rates at Caesarean Toronto, ON, Canada, April 2017. Toronto, ON, Canada, April 2017. Delivery in Women with Abnormal Saini B, Ducas R, Bhagra C, Stochitoiu Invasive Placentation. Department of Vainder M, Kives S, Yudin MH. Rates I, Zhu J, Portnoy S, Sled J, Sermer M, Obstetrics & Gynaecology, University of Gonorrhea and Chlamydia Screening Macgowan C, Kingdom JC, Wald R, Seed of Toronto, 34th Annual Research Day. Among Pregnant Women Presenting M. Maternal and Fetal Hemodynamics by Toronto, ON, Canada, April 2017. for Prenatal Care. Department of Cardiovascular Magnetic Resonance in Obstetrics & Gynaecology, University Szaraz P, Librach M, Maghen L, Barretto Normal Controls and Women with Heart of Toronto, 34th Annual Research Day. T, Kenigsberg S, Gauthier-Fisher A, Disease. 4th Paediatric Heart Failure Toronto, ON, Canada, April 2017 Librach CL. First Trimester Human Summit. The Hospital for Sick Children. Umbilical Cord Perivascular Cells Vyas P, Balakier H, Librach CL. Human Toronto, ON, Canada, September 2016. Differentiated into Immunoprivileged, Pre-implantation Embryos Exhibit Saini B, Portnoy S, Yuan Zhu M, Porayette Contracting Cardiomyocyte-like Cells Morphokinetic and Metabolic Signatures P, QiDuan A, Mei Lim J, Windrim R, Sled In Vitro. International Conference on that may Predict Embryo Competency

122 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY Local Abstract Presentations

During IVF Treatment. Department of Society of Extracellular Vesicles. for Group B Streptococcus Among Obstetrics & Gynaecology, University Toronto, ON, Canada, May 2017. Pregnant Women. Association of Medical of Toronto, 34th Annual Research Day. Microbiology and Infectious Disease Yasovich N, Filice M, Moskovtsev Toronto, ON, Canada, April 2017. (AMMI) Canada Annual Conference. SI, Gauthier−Fishe A, Librach CL. May 2017, Toronto, ON, Canada. Wat J, Baczyk D, Kingdom JC. Non- Utilization of Imaging Flow Cytometry for anticoagulant Actions of Low-molecular the Identification of Rare Spermatozoa Zohni K, Lopez L, Szaraz P, Filice M, Wyse Weight Heparin in Preeclampsia. in Patients with Non-obstructive B, Garcia M, Gat I, Glass K, Gauthier-Fisher Department of Obstetrics & Gynaecology, Azoospermia. Canadian Fertility and A, Librach CL. Human Umbilical Cord University of Toronto, 34th Annual Research Andrology Society Annual Meeting. Perivascular Cells (HUCPVCs) Maintain Day. Toronto, ON, Canada, April 2017. Toronto, ON, Canada, September 2016. Mesenchymal Stromal Cell Characteristics and Regenerative Properties After Weiner E, Kahn M, Giltvedt K, Sherman Yang H, Rogers I, Nagy A. Systemic and Chemotherapy Exposure. Department C, Kingdom JC, Barrett J, Melamed Local Modulation of the Immune Response of Obstetrics & Gynaecology, University N. Suboptimal Placental Perfusion is a to Allogenic Cell Transplants. Department of Toronto, 34th Annual Research Day. Potential Mechanism for IUGR and Worse of Obstetrics & Gynaecology, University Toronto, ON, Canada, April 2017. Perinatal Outcomes of Non-presenting of Toronto, 34th Annual Research Day. Fetuses in Dichorionic Twins. Department Toronto, ON, Canada, April 2017. Zohni K, Szaraz P, Filice M, Lopez L, of Obstetrics & Gynaecology, University Garcia M, Gat I, Gauthier-Fisher A, Glass Yang H, Rogers I, Nagy A. Systemic and of Toronto, 34th Annual Research Day. K, Librach CL. Human Umbilical Cord Local Modulation of the Immune Response Toronto, ON, Canada, April 2017. Perivascular Cells (HUCPVCs) Maintain to Allogenic Cell Transplants. Lunenfeld- Mesenchymal Stromal Cell Characteristics Weiner E, Melamed N. Nonpresenting Tanenbaum Research Institute Scientific and Regenerative Properties After Dichorionic Twins and Placental Retreat. Orillia, ON, Canada, May 2017. Chemotherapy Exposure: A Promising Vascular Malperfusion.Department of Yee B, Lee A, Zhang J, Yasovich N, Hahn Cell Candidate for Gonadotoxicity Obstetrics & Gynaecology, University K, Moskovstev S, Librach CL. Effects Prevention. Canadian Fertility and of Toronto, 34th Annual Research Day. of Density Gradient Centrifugation Andrology Society Annual Meeting. Toronto, ON, Canada, April 2017. Sperm Isolation Method on Human Toronto, ON, Canada, September 2016. Wuebbolt D, Nguyen V, Thomas H, Bui E, Sperm DNA Damage. Department of Murphy KE, D’Souza R. Preferences of Obstetrics & Gynaecology, University Pregnant Women with and without Epilepsy of Toronto, 34th Annual Research Day. for Health States Related to the Use of Toronto, ON, Canada, April 2017. Anti-epileptic Medications in Pregnancy. Yeo SC, Shathasivam P, Kollara A, Brown Department of Obstetrics & Gynaecology, TJ. Regulation of mTOR by Human Orthology University of Toronto, 34th Annual Research of Drosphila Melted. China-Canada-USA Day. Toronto, ON, Canada, April 2017. Pharmacology/Physiology Conference. Wyse B, Kenigsberg S, Balakier H, Toronto, ON, Canada, June 2017. Caballero J, Gat I, Librach CL. Differential Yeo S, Shathasivam P, Kollara A, Brown eExpression of Long Noncoding RNAs TJ. VEPH1 Decreases TSC1: A Potential in Cumulus Cells Isolated from Oocytes Modulation of mTOR Signaling. Department at Different Stages of Maturation. of Obstetrics & Gynaecology, University Canadian Fertility and Andrology of Toronto, 34th Annual Research Day. Society Annual Meeting. Toronto, Toronto, ON, Canada, April 2017. ON, Canada, September 2016. Yudin MH, Tadros M, Nadarajah J, Hasso Wyse B, Shlomit K, Librach CL. Human M, Beatty C, Cirone V, Lacroix M, De Souza Follicular Fluid-derived Exosome L, Geary M, Matukas LM. A Comparison (Folliculosome) RNA Content is Associated of eSwab and M40 Swabs for Testing with Ovarian Reserve. International

ANNUAL REPORT 2016/17 123 COMMON ABBREVIATIONS

AACR American Association for CFAS Canadian Fertility and CCSRI Canadian Cancer Society Cancer Research Andrology Society Research Institute AAGL American Association of CAGS Canadian Association of CDA Canadian Diabetes Gynaecologic Laparos- General Surgeons Association copists CAHR Canadian Association of CEPD Continuing Education AAP American Academy of HIV Research and Professional Paediatrics Development CAHSPR Canadian Association (University of Toronto) ABOG American Board for Health Services and of Obstetrics and Policy Research CERI Canadian Epilepsy Gynaecology Research Initiative CanDIPS Canadian Diabetes in ABU American Board of Pregnancy Study Group CFPC College of Family Urology Physicians of Canada CANN Canadian Association of ACOG American Congress Neonatal Nurses CFRC Centre for Fertility of Obstetricians and and Reproductive Care Gynaecologists CANPAGO Canadian Paediatric and (MSH) Adolescent Gynaecology ACS American Cancer Society and Obstetricians CHI Canada Health Infoway (SOGC) AEPC Association for European CHU Centre hospitalier Paediatric Cardiology CAPHC Canadian Association of universitaire Paediatric Health Centres Sainte-Justine AHA American Heart Association CAPRI Canadian Alliance for CIHR Canadian Institutes of Paediatric Rheumatology Health Research AHFMR Alberta Heritage Investigators Foundation for Medical CMAS The Centre for Minimal Research CAPSNet Canadian Paediatric Access Surgery Surgery Network AHSC Academic Health CMICR The Centre for Mother, Sciences Centres CAR Canadian Association of Infant, and Child Radiologists Research AIUM American Institute of Ultrasound in Medicine CaRMS The Canadian Resident COGI World Congress on Matching Service Obstetrics, Gyanecology AMPATH Academic Model and Infertility Providing Access to CARO/ACRO Canadian Association of Healthcare Radiation Oncology | COMEGO Colegio Mexicano Association canadienne de Especialistas en APGO Association of Professors de radio-oncologie Ginecología y of Gynaecology and Obstetricia, A.C. Obstetrics CBCF Canadian Breast Cancer Foundation COSA Clinical Oncological APOG The Association of Society of Australia Academic Professionals CBCRA Canadian Breast Cancer in Obstetrics and Research Alliance CPA Canadian Physiotherapy Gynaecology of Canada Association CCASN Canadian Congenital ASBMR American Society for Anomalies Surveillance CPAC Canadian Partnership Bone and Mineral Network Against Cancer Research CCC Canadian Cardiovascular CPS Canadian Paediatric ASCCP American Society for Congress Society Colposcopy and Cervical Pathology CCHCSP Canadian Child Health CREMS Comprehensive Research Clinician Scientist Experience for Medical ASCP American Society for Program Students Clinical Pathology CFPC College of Family CREOG Council on Resident ASCO American Society of Physicians of Canada Education in Obstetrics Clinical Oncology and Gyanecology CCME Canadian Conference on ASHG American Society of Medical Education CSEM Canadian Society of Human Genetics Endocrinology and CCMG Canadian College of Metabolism ASRM American Society for Medical Geneticists Reproductive Medicine CSMFM Canadian Society of CCMS Chinese Canadian Maternal Fetal Medicine AWHONN Association of Women’s Medical Society Heath, Obstetric and (Ontario) CSTM Canadian Society for Neonatal Nurses Transfusion Medicine CCO Cancer Care Ontario BICOG British International CTN CIHR Canadian HIV Congress of Obstetrics CCOCR Canadian Conference on Trials Network and Gynaecology Ovarian Cancer Research

124 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY COMMON ABBREVIATIONS

CUA Canadian Urologic ICAAC Interscience Conference ISSTD International Society Association on Antimicrobial Agents for the Study of and Chemotherapy Trophoblastic Diseases DPSG Diabetic Pregnancy Study Group ICONN The International IUGA International Collaboration of Urogynaecological EASD European Association for Neonatal Networks Association the Study of Diabetes ICS International Continence LHIN Local Health Integration ECNP European College of Society Network Neuropsychopharma- cology ICHG International Congress LTRI Lunenfeld-Tanenbaum of Human Genetics Research Institute EORTC European Organisation for Research and IDSA Infectious Diseases MEFS Middle East Fertility Treatment of Cancer Society of America Society EPA European Placenta Group IDSOG Infectious Diseases MICYRN Maternal Infant Child Society for Obstetrics and Youth Research ESC European Society of and Gynaecology Network Cardiology IEEE Institute of Electrical and MOHLTC Ministry of Health ESGE European Society Electronics Engineers and Long-Term Care for Gynaecological (Ontario) Endoscopy IFMSS The International Fetal Medicine and Surgery MSH Mount Sinai Hospital ESHRE European Society of Society Human Reproduction NAFTNet The North American and Embryology IFPA International Federation Fetal Therapy Network of Placenta Associations FAIS Federation of African NAMS North American Immunological Societies IGORS International Menopause Society Gynaecologic Oncology FAOPS Federation of Asian Robotic Symposium NASOM North American Society and Oceania Perinatal of Obstetric Medicine Societies IGCS International Gynaecologic Cancer NASPAG North American FCMS Federation of Chinese Society Society for Paediatric and American and Chinese Adolescent Gynaecology Canadian Medical IHDCYH Institute of Human Societies Development, Child and NESA New European Surgical Youth Health Academy FIGO International Federation of Gynaecology and IMS International Menopause NCI National Cancer Institute Obstetrics Society NIDA National Institute on FMWC Federation of Medical INTAPP An International Drug Abuse Women of Canada Trial of Antioxidants NIH National Institutes of in the Prevention of Health FORCE Facing Our Risk of Preeclampsia Cancer Empowered NSERC Natural Sciences and IPEG International Paediatric Engineering Research GAPPS Global Alliance to Endoscopy Group Prevent Prematurity and Council of Canada Stillbirth IPE Interprofessional NYGH North York General Education GOC The Society of Hospital Gynaecologic Oncology IPOS International NYSORA The New York School of Canada Psycho-Oncology of Regional Anesthesia Society GOGO Gynaecologic Oncology OCFP Ontario College of Group Ontario ISDS International Skeletal Family Physicians Dysplasia Society GREI Gynaecologic OGS/OGSST Ontario Graduate Reproductive ISMRM The International Society Scholarship/Ontario Endocrinology & for Magnetic Resonance Graduate Scholarship in Infertility in Medicine Science and Technology HHR Health and Human ISSCR International Society for OHTAC Ontario Health Relations Stem Cell Research Technology Advisory HSFO Heart and Stroke ISSHP The International Committee Foundation of Ontario Society for the Study OMA Ontario Medical of Hypertension in Association HUPO Human Proteome Pregnancy Organisation OOA Obstetric Anaesthetists’ IBD Inflammatory Bowel Association Disease

ANNUAL REPORT 2016/17 125 Common Abbreviations

OTIS Organization of SHUTC Sunnybrook Hospital USCAP United States and Teratology Information University of Toronto Canadian Academy of Specialists Clinic (legal name, Pathology operates, as of 1973, as PAG Paediatric and Adolescent Academic Clinicians’ WAGO Western Association Gynaecology Management Services) of Gynaecologic Oncologists PARO Professional Association SIBEN SIBEN, the Sociedad of Residents of Ontario Iberoamericana de WEBC Weekend to End Breast Cancer PAS The Paediatric Academic Neonatología Societies SIECCAN Sex Information and WFUMB World Federation for Education Council of Ultrasound in Medicine PCRS Pacific Coast and Biology Reproductive Society Canada SIR Society of Interventional WHI Women’s Health PEBC Program in Initiative Evidence-Based Care Radiology SJHC St. Joseph’s Health WHO World Health PMH Princess Margaret Organization Hospital Centre SK SickKids WRGC World Robotic PNOGA Pacific Northwest Gynaecology Congress Obstetrical and SLS Society of Gynaecological Laparoendoscopic Association Surgeons POGO Paediatric Oncology SMFM Society for Group of Ontario Maternal-Fetal Medicine PREBIC Preterm Birth Collective SMH St. Michael’s Hospital PSANZ Perinatal Society of SMIG Society of Minimally Australia and New Invasive Gynaecology Zealand SOGC Society of Obstetricians PSI Physicians’ Services and Gynaecologists of Incorporated Canada QBP Quality-Based SOGIBA Sociedad de Obstetricia Procedures y Ginecología de Buenos RCOG Royal College of Aires Obstetricians and SOGS Saudi Obstetrics and Gynaecologists (UK) Gynaecological Society RCT Randomized Control SOGT Society of Obstetricians Trials and Gynaecologists of RCPSC Royal College of Toronto Physicians and Surgeons SORB Southern Ontario of Canada Reproductive Biology RSNA Radiological Society SSR Society for the Study of North America of Reproduction SAEM Society for Academic STGO Tunisian Societies Emergency Medicine of Gynaecology and SAGES Society of American Obstetrics Gastrointestinal and STLHE Society for Teaching Endoscopic Surgeons and Learning in Higher SCMR Society of Cardiovascular Education Magnetic Resonance TAHSN Toronto Academic SGI Society for Gynaecologic Health Science Network Investigation TEGH Toronto East General SGO Society of Gynaecologic Hospital Oncology TWH Toronto Western SHSC Sunnybrook Health Hospital at UHN Sciences Centre UGSA UroGynaecological Society of Australasia UHN University Health Network

126 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY ANNUAL REPORT 2016/17 127 UNIVERSITY OF TORONTO TORONTO OF UNIVERSITY OBSTETRICS & GYNAECOLOGY & GYNAECOLOGY OBSTETRICS ANNUAL REPORT 2016–2017 REPORT ANNUAL

Department of Obstetrics & Gynaecology Faculty of Medicine University of Toronto 123 Edward Street, Suite 1200 Toronto, ON M5G 1E2 Canada Tel: 416-978-2216 Fax: 416-978-8350

obgyn.utoronto.ca /uoftobgyn @uoftobgyn #uoftobgyn

128 UNIVERSITY OF TORONTO OBSTETRICS & GYNAECOLOGY