DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2009/0156670 A1 Chaudhary (43) Pub

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2009/0156670 A1 Chaudhary (43) Pub US 20090156670A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0156670 A1 Chaudhary (43) Pub. Date: Jun. 18, 2009 (54) NONAQUEOUS LIQUID PARENTERAL Publication Classification ACECLOFENAC FORMULATION (51) Int. Cl. Inventor: Manu Chaudhary, Haryana (IN) A6II 3L/26 (2006.01) (75) A6IP 29/00 (2006.01) Correspondence Address: (52) U.S. Cl. ........................................................ 514/533 Laura A. Chub AMIN HALLIAN, LLC (57) ABSTRACT 217 N. Jefferson Street, Suite 100 A nonaqueous liquid parenterally deliverable pharmaceutical Chicago, IL 60661 (US) formulation, and more particularly a nonaqueous liquid parenteral Aceclofenac formulation comprising the selective (73) Assignee: VENUS REMEDIES LIMITED, NSAID Aceclofenac, is disclosed. A process of preparing Panchkula- Haryana (IN) Aceclofenac formulation, the therapeutic dosage form and storage of dose, and the method of treating a subject having a (21) Appl. No.: 11/719,906 condition or a disorder wherein treatment with NSAID is indicated, are also disclosed. Diclofenac formed by conver (22) PCT Fled: Oct. 19, 2005 sion of Aceclofenac is solubilized by the nonaqueous solubi PCT NO.: PCT/IN05/00339 lizer(s), which are substantially inert with respect to such (86) conversion. The composition has Aceclofenac salt stabilizing S371 (c)(1), means for inhibiting precipitation of Aceclofenac. The com May 22, 2007 positions disclosed in the present invention are stable upon (2), (4) Date: storage at room temperature and at refrigerated temperatures. (30) Foreign Application Priority Data Compositions disclosed in the present invention, whether ready-to-use or requiring dilution prior to administration, can Nov. 22, 2004 (IN) ........................... 2332/DELA2004 be prepared by inexpensive processes disclosed herein. US 2009/0156670 A1 Jun. 18, 2009 NONAQUEOUS LIQUID PARENTERAL drug typically results in attainment of a therapeutically effec ACECLOFENAC FORMULATION tive blood serum concentration of the drug in a shorter time than is achievable by oral administration. This is especially FIELD OF INVENTION true of intravenous injection, whereby the drug is placed 0001. The present invention generally relates to nonaque directly in the bloodstream. Parenteral administration can ous liquid parenterally deliverable pharmaceutical formula also result in more predictable blood serum concentrations of tion and more particularly to nonaqueous liquid parenteral a drug, because losses in the gastrointestinal tract due to metabolism, binding to food and other causes are eliminated. Aceclofenac formulation comprising the selective NSAID For similar reasons, parenteral administration often permits Aceclofenac and still more particularly to pharmaceutically dose reduction. Parenteral administration is generally the pre acceptable salts of Aceclofenac. The invention also relates to ferred method of drug delivery in emergency situations, and is a process of preparing Aceclofenac formulation, the thera also useful in treating Subjects who are uncooperative, uncon peutic dosage form and storage of dose, and the method of scious, or otherwise unable or unwilling to accept oral medi treating a Subject having a condition or a disorder wherein cation, and where a faster relief is required in lesser time, treatment with NSAID is indicated. specially in acute and chronic painful condition. 0022. If a parenteral drug formulation is to be prepared, it BACKGROUND OF INVENTION is preferable from patient convenience and safety standpoints 0002 The non-steroidal anti-inflammatory drug (NSAID) that such a formulation be a ready-to-use formulation, i.e. one has a wide range and it is. available both in non-prescription that does not require dilution or mixing immediately prior to and prescription mode. The major groups of NSAID are as use (as opposed to a reconstitutable formulation). Ready-to follows: use and dilutable liquid parenteral formulations can also be 0003 a. Salicyclic acid group: aspirin (acetyl salicyclic advantageous from a manufacturing standpoint by avoiding acid), Choline magnesium trisalicylate, diflunisal and sal expensive iyophilization and/or other similar manufacturing salate. steps. 0004 b. Propionic acid group: fenoprofen, flurbiprofen, 0023 Aceclofenac is a phenyl acetic acid derivative which ibuprofen, ketoprofen, naproxen, and Oxaprozin. inhibits interleukin 18-induced prostaglandin E2 production 0005 c. Acetic and acid group: diclofenac, aceclofenac, but has poor COX-I inhibitor effect in oral form. This formu indomethacin, Sulindac, and tolmetin. lation converts it to the Diclofenac, the COX-I and COX-II 0006 d. Enolic acid group: meloxicam and piroxicam. inhibitor, following administration to a subject, itself shows 0007 e. Fenamic acid group: meclofenamate and mefe enhanced inhibitory activity against both COX-1 and COX-2. namic acid. 0024. Because Diclofenac has very poor gastrointestinal 0008 f. Napthylalkenone group: nabumetone. (GI) tolerability, it is not particularly well suited for formu 0009. g. Pyarnocarboxylic acid group: etodallac. lation. By contrast, because of the better GI tolerability of 0010 h. Pyrrole group: Keterolac. aceclofenac and lesser side effects than diclofenac, Ace 0011 i. COX-2 inhibitor group: Celecoxib, Valdecoxib clofenac has been proposed by the inventor for liquid formu and rofecoxib. lation. 0012 Some of different NSAIDs are available in one or 0025. Unfortunately, attempts to formulate Aceclofenac more forms like tablets, injections, and dry powder for injec as a ready-to-use solution for injection have heretofore been tion form. The present invention relates to “ready to use complicated by the fact that Aceclofenac, when in solution injection of aceclofenac. and especially in presence of certain excipients, is unstable, 0013 The disadvantages of other NSAIDs as compared to and undergoes degradation which may precipitate out making the present invention are given below. injection unsuitable for use. 0014) 1) Dry powder injectable NSAID needs to be lyo 0026. One potential solution to this problem is to provide philized and then reconstituted before use. The process is a dry reconstitutable Aceclofenac formulation which is mixed costly and cumbersome. with a liquid vehicle just prior to administration but this too is 0015. 2) Injection form is more advantageous over oral not stable for longer period. However, in many situations it is form as serum concentration of oral NSAID is lesser because particularly advantageous to provide a liquid formulation, of intestinal metabolism of the drug. more especially a ready-to-use formulation, as indicated 0016 3) Serum concentration of oral NSAID is unpredict above. able. 0027. If a liquid parenterally deliverable formulation of 0017 4) The frequency of administration of oral NSAID is Aceclofenac or a pharmaceutically acceptable salt thereof, higher. particularly Such a formulation that is ready-to-use, that is 0018 5) Diclofenac has more side-effects than Ace storage stable at room temperature could be prepared, a sig clofenac. nificant advance in treatment of COX-2 mediated conditions 0019 6) NSAID's injections such as indometacin have and disorders would result. This would be especially true for lesser tolerability than Aceclofenac. Such conditions and disorders characterized by or accompa 0020 7) Ketoprofen is less stable than Aceclofenac. nied by pain, particularly where rapid onset of pain relief is 0021 Parenteral drug formulations have become a very desired (as, for example, in migraine and otherforms of acute important component in the arsenal of available drug delivery and/or severe pain). options, particularly for drugs having analgesic effect. (0028 US Patent application publication no. 20040180961 Parenteral routes of administration, including Subcutaneous, of Lee, Beom-Jin, etal discuss the composition and prepara intramuscular and intravenous injection, offer numerous ben tion method for bioavailable oral Aceclofenac dosage forms. efits over oral delivery in particular situations, for a wide The composition contains water-insoluble Aceclofenac, a variety of drugs. For example, parenteral administration of a polymeric base and a Surfactant. It is stated that the oral US 2009/0156670 A1 Jun. 18, 2009 preparation according to this invention has excellent solubil found to be significantly more effective than ketoprofen, both ity in gastrointestinal tract, thereby improving dissolution with regard to the Ritchie Index and morning stiffness. rate and thus bioavailability, as well as rapid dispersion and 0034. The main disadvantage of long-term therapy with dissolution properties in gastrointestinal tract. In addition, NSAIDs is the risk of gastrointestinal disturbances. NSAIDs when being orally administered in an amount much smaller carry a greater risk of inducing upper gastrointestinal bleed than the conventional preparation, the oral preparation is ing than simple analgesics, though the risk is dependent on therapeutically effective, thus minimizing gastrointestinal the dose and is highest in patients who have previously suf disorder. fered bleeding episodes. Ibuprofen and diclofenac have recently been shown to be the NSAIDs, of those most fre 0029 G. Pasero et al., in their paper “A multi-centre, quently used, which have the lowest risk of causing upper double-blind comparative study of the efficacy and safety of gastrointestinal bleeding. Any NSAID which, therefore, has aceclofenac and diclofenac in the treatment of rheumatoid comparable or better gastrointestinal
Load more

Recommended publications
  • Colitis Caused by Non-Steroidal Anti-Inflammatory Drugs
    Postgrad Med J: first published as 10.1136/pgmj.62.730.773 on 1 August 1986. Downloaded from Postgraduate Medical Journal (1986) 62, 773-776 Colitis caused by non-steroidal anti-inflammatory drugs S. Ravi', A.C. Keat2 and E.C.B. Keat1 'Cuckfield Hospital, Cuckfield, West Sussex, and2Westminster Hospital, Horseferry Road, London SWIP2AP, UK. Summary: Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid relapse. Introduction Ulcerative colitis is a disease of unknown aetiology Case reports with characteristic clinical features and a protracted course. A similar clinical picture, but running a shorter Case I and usually benign course, is occasionally seen follow- ing the administration of certain drugs. This was first A 77 year old woman was referred with intermittent noticed following the administration of antibiotics, bleeding per rectum for 6 months, associated for the often with pseudomembrane formation. Later, this last 2 months with bloody diarrhoea up to eight times was shown to be associated with infection by toxigenic daily. Previously, she had had troublesome symptoms Clostridium difficile. Until 1978, most cases were from osteoarthritis of her back and knees for which copyright. associated with treatment with clindamycin but since she had been prescribed flufenamic acid 200 mg thrice that time nearly all antibiotics have been implicated. daily. Her general health had remained good but she Other drugs capable of causing proctocolitis, though appeared pale and her haemoglobin was reduced to by different mechanisms, include phenindione (Keat & 8 g/dl.
    [Show full text]
  • United States Patent [19] [11] Patent Number: 6,149,923 Shirahase Et Al
    US006149923A United States Patent [19] [11] Patent Number: 6,149,923 Shirahase et al. [45] Date of Patent: Nov. 21, 2000 [54] ANTIRHEUMATIC AGENT OTHER PUBLICATIONS [75] Inventors: Hiroaki Shirahase, Nagaokakyo; Yoshimi et al Importance of Hydrolysis of Amino Acid Akihisa Yoshimi, Takatsuki; Fumio Moiety in Water—Soluble Prodrugs of Disodium Cromogly Fukata, Osaka; Hideki Okunishi; Yuta cate for Increased Oral Bioavailability 1992 J. Pharmaco Kobayashi, both of IZumo, all of Japan bio—Dyn 15:339—345. Mori et al Pro—drugs for the Oral Deliver of Disodium [73] Assignee: Kyoto Pharmaceutical Industries, Cromoglycate 1988 Chem. Pharm. Bull. 36:338—344. Ltd., Kyoto, Japan Primary Examiner—Thurman K. Page Appl. N0.: Assistant Examiner—Todd D. Ware 09/202,368 Attorney, Agent, or Firm—Leydig, Voit & Mayer, Ltd. PCT Filed: Jun. 6, 1997 [57] ABSTRACT PCT No.: PCT/JP97/01974 An antirheumatic agent comprising diethyl § 371 Date: Dec. 10, 1998 L-lysylcromoglycate of the following formula § 102(e) Date: Dec. 10, 1998 NH; PCT Pub. No.: WO97/47297 [87] OCOCH(CH2)4NH2 PCT Pub. Date: Dec. 18, 1997 o OCHZCHCHZO o [30] Foreign Application Priority Data Jun. 11, 1996 [JP] Japan .................................. .. 8-149549 [51] Int. Cl.7 .......................... .. A61K 9/00; A61K 31/35; A01N 43/16 H5c2ooc o o cooczns US. Cl. ......................... .. 424/400; 514/825; 514/456 Field of Search ........................... .. 424/400; 514/825, or a nontoxic salt thereof as an active ingredient. This 514/456 compound has an anti-in?ammatory action and immuno modulating action, is absorbed by oral administration to be References Cited delivered efficiently to local sites, and is associated With feWer side effects, so that it serves Well as an antirheumatic U.S.
    [Show full text]
  • Solid Solution Compositions and Use in Chronic Inflammation
    (19) *EP003578172A1* (11) EP 3 578 172 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 11.12.2019 Bulletin 2019/50 A61K 9/14 (2006.01) A61K 47/14 (2017.01) A61K 47/44 (2017.01) A61K 31/12 (2006.01) (2006.01) (2006.01) (21) Application number: 19188174.7 A61K 31/137 A61K 31/167 A61K 31/192 (2006.01) A61K 31/216 (2006.01) (2006.01) (2006.01) (22) Date of filing: 14.01.2014 A61K 31/357 A61K 31/366 A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/522 (2006.01) A61K 31/616 (2006.01) A61K 31/196 (2006.01) (84) Designated Contracting States: • BREW, John AL AT BE BG CH CY CZ DE DK EE ES FI FR GB London, Greater London EC2Y 8AD (GB) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • REILEY, Richard Robert PL PT RO RS SE SI SK SM TR London, Greater London EC2Y 8AD (GB) • CAPARRÓS-WANDERLEY, Wilson (30) Priority: 14.01.2013 US 201361752356 P London, Greater London EC2Y 8AD (GB) 04.02.2013 US 201361752309 P (74) Representative: Clements, Andrew Russell Niel et (62) Document number(s) of the earlier application(s) in al accordance with Art. 76 EPC: Schlich 14702460.8 / 2 925 367 9 St Catherine’s Road Littlehampton, West Sussex BN17 5HS (GB) (71) Applicant: InFirst Healthcare Limited London EC2Y 8AD (GB) Remarks: This application was filed on 24-07-2019 as a (72) Inventors: divisional application to the application mentioned • BANNISTER, Robin Mark under INID code 62.
    [Show full text]
  • Comparing the Effects of Salts of Diclofenac and Almioprofen with Aspirin on Serum Electrolytes, Creatinine and Urea Levels in Rabbits
    Comparing the effects of salts of diclofenac and almioprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits Nawazish-i-Husain Syed*, Farnaz Zehra, Amir Ali Rizvi Syed, Sabiha Karim and Farrakh Zia Khan University College of Pharmacy, University of the Punjab, Lahore, Pakistan Abstract: The effects of diclofenac sodium, diclofenac potassium, alminoprofen and aspirin on serum electrolytes (serum Na+ and K+), urea and creatinine were compared in rabbits in acute and chronic phases of treatment. The data suggested that all the four drugs markedly increased the serum electrolytes, urea and creatinine levels in both post- treatment phases. In conclusion, present study does not present any advantage of diclofenac sodium over diclofenac potassium at electrolyte levels on short and long term treatment. Nevertheless, current data support the evidence of renal function impairment by all the four drug therapies used in the present study, which is generally caused by NSAIDS. Keywords: NSAIDs, renal function, serum electrolytes. INTRODUCTION were given fodder twice daily, while water was available ad libitum. Throughout the study, environmental Inflammatory diseases including rheumatoid arthritis and conditions remained constant. Rabbits were divided into osteoarthritis are initially treated with non-steroidal anti- five groups, each of six animals. Same group of animals inflammatory drugs (NSAIDS) (Patrono and Rocca, were used for acute and chronic phases of the study. In 2009). Previously, steroids were prescribed to manage the both studies, rabbits of each group were orally chronic inflammatory diseases, however, due to their administered diclofenac Na+, diclofenac K+, severe adverse effects, NSAIDS has become the first alminoprofen, acetyl salicylic acid in a doses of 2.5mg, choice to treat these diseases.
    [Show full text]
  • Table S1: Sensitivity, Specificity, PPV, NPV, and F1 Score of NLP Vs. ICD for Identification of Symptoms for (A) Biome Developm
    Table S1: Sensitivity, specificity, PPV, NPV, and F1 score of NLP vs. ICD for identification of symptoms for (A) BioMe development cohort; (B) BioMe validation cohort; (C) MIMIC-III; (D) 1 year of notes from patients in BioMe calculated using manual chart review. A) Fatigue Nausea and/or vomiting Anxiety Depression NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.99 (0.93- 0.59 (0.43- <0.00 0.25 (0.12- <0.00 <0.00 0.54 (0.33- Sensitivity 0.99 (0.9 – 1) 0.98 (0.88 -1) 0.3 (0.15-0.5) 0.85 (0.65-96) 0.02 1) 0.73) 1 0.42) 1 1 0.73) 0.57 (0.29- 0.9 (0.68- Specificity 0.89 (0.4-1) 0.75 (0.19-1) 0.68 0.97 (0.77-1) 0.03 0.98 (0.83-1) 0.22 0.81 (0.53-0.9) 0.96 (0.79-1) 0.06 0.82) 0.99) 0.99 (0.92- 0.86 (0.71- 0.94 (0.79- 0.79 (0.59- PPV 0.96 (0.82-1) 0.3 0.95 (0.66-1) 0.02 0.95 (0.66-1) 0.16 0.93 (0.68-1) 0.12 1) 0.95) 0.99) 0.92) 0.13 (0.03- <0.00 0.49 (0.33- <0.00 0.66 (0.48- NPV 0.89 (0.4-1) 0.007 0.94 (0.63-1) 0.34 (0.2-0.51) 0.97 (0.81-1) 0.86 (0.6-0.95) 0.04 0.35) 1 0.65) 1 0.81) <0.00 <0.00 <0.00 F1 Score 0.99 0.83 0.88 0.57 0.95 0.63 0.82 0.79 0.002 1 1 1 Itching Cramp Pain NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.98 (0.86- 0.24 (0.09- <0.00 0.09 (0.01- <0.00 0.52 (0.37- <0.00 Sensitivity 0.98 (0.85-1) 0.99 (0.93-1) 1) 0.45) 1 0.29) 1 0.66) 1 0.89 (0.72- 0.5 (0.37- Specificity 0.96 (0.8-1) 0.98 (0.86-1) 0.68 0.98 (0.88-1) 0.18 0.5 (0-1) 1 0.98) 0.66) 0.88 (0.69- PPV 0.96 (0.8-1) 0.8 (0.54-1) 0.32 0.8 (0.16-1) 0.22 0.99 (0.93-1) 0.98 (0.87-1) NA* 0.97) 0.98 (0.85- 0.57 (0.41- <0.00 0.58 (0.43- <0.00 NPV 0.98 (0.86-1) 0.5 (0-1) 0.02 (0-0.08) NA* 1) 0.72) 1 0.72) 1 <0.00 <0.00 <0.00 F1 Score 0.97 0.56 0.91 0.28 0.99 0.68 1 1 1 *Denotes 95% confidence intervals and P values that could not be calculated due to insufficient cells in 2x2 tables.
    [Show full text]
  • Investigating the Influence of Polymers on Supersaturated
    Page 1 of 45 Molecular Pharmaceutics 1 2 3 4 5 6 7 Investigating the Influence of Polymers on 8 9 10 11 12 Supersaturated Flufenamic Acid Cocrystal Solutions 13 14 15 16 1 1 2 2 1 17 Minshan Guo , Ke Wang , Noel Hamill , Keith Lorimer and Mingzhong Li * 18 19 20 1School of pharmacy, De Montfort University, Leicester, UK 21 22 23 2Almac Science, Seagoe Industrial Estate, Craigavon, UK 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 ACS Paragon Plus Environment 1 Molecular Pharmaceutics Page 2 of 45 1 2 3 4 5 6 7 Table of contents graphic 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 ACS Paragon Plus Environment 2 Page 3 of 45 Molecular Pharmaceutics 1 2 3 Abstract 4 5 6 7 The development of enabling formulations is a key stage when demonstrating the effectiveness 8 9 10 of pharmaceutical cocrystals to maximize the oral bioavailability for poorly water soluble drugs. 11 12 Inhibition of drug crystallization from a supersaturated cocrystal solution through a fundamental 13 14 understanding of the nucleation and crystal growth is important. In this study, the influence of 15 16 17 the three polymers of polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and a copolymer 18 19 of N-vinly-2-pyrrodidone (60%) and vinyl acetate (40%) (PVP-VA) on the flufenamic acid 20 21 22 (FFA) crystallization from three different supersaturated solutions of the pure FFA and two 23 24 cocrystals of FFA-NIC CO and FFA-TP CO has been investigated by measuring nucleation 25 26 induction times and desupersaturation rates in the presence and absence of seed crystals.
    [Show full text]
  • Use of Aspirin and Nsaids to Prevent Colorectal Cancer
    Evidence Synthesis Number 45 Use of Aspirin and NSAIDs to Prevent Colorectal Cancer Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov Contract No. 290-02-0021 Prepared by: University of Ottawa Evidence-based Practice Center at The University of Ottawa, Ottawa Canada David Moher, PhD Director Investigators Alaa Rostom, MD, MSc, FRCPC Catherine Dube, MD, MSc, FRCPC Gabriela Lewin, MD Alexander Tsertsvadze, MD Msc Nicholas Barrowman, PhD Catherine Code, MD, FRCPC Margaret Sampson, MILS David Moher, PhD AHRQ Publication No. 07-0596-EF-1 March 2007 This report is based on research conducted by the University of Ottawa Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0021). Funding was provided by the Centers for Disease Control and Prevention. The findings and conclusions in this document are those of the author(s), who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment. This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.
    [Show full text]
  • Aceclofenac As a Potential Threat to Critically Endangered Vultures in India: a Review Author(S): Pradeep Sharma Source: Journal of Raptor Research, 46(3):314-318
    Aceclofenac as a Potential Threat to Critically Endangered Vultures in India: A Review Author(s): Pradeep Sharma Source: Journal of Raptor Research, 46(3):314-318. 2012. Published By: The Raptor Research Foundation DOI: http://dx.doi.org/10.3356/JRR-11-66.1 URL: http://www.bioone.org/doi/full/10.3356/JRR-11-66.1 BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Your use of this PDF, the BioOne Web site, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/ page/terms_of_use. Usage of BioOne content is strictly limited to personal, educational, and non- commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research. SHORT COMMUNICATIONS J. Raptor Res. 46(3):314–318 E 2012 The Raptor Research Foundation, Inc. ACECLOFENAC AS A POTENTIAL THREAT TO CRITICALLY ENDANGERED VULTURES IN INDIA:AREVIEW PRADEEP SHARMA1 Department of Veterinary Microbiology and Biotechnology, Rajasthan University of Veterinary and Animal Science, Bikaner 334001, Rajasthan, India KEY WORDS: Vultures; Gyps; aceclofenac; diclofenac; India; cations in humans (Kay and Alldred 2003) and marked South Asia; toxicity. analgesic, antiarthritic and antipyretic properties.
    [Show full text]
  • Rationale of Aceclofenac in Management of Pyrexia in Paediatric Practice
    ISSN: 2574-1241 Volume 5- Issue 4: 2018 DOI: 10.26717/BJSTR.2018.11.002112 Avinash Shankar. Biomed J Sci & Tech Res Research Article Open Access Rationale of Aceclofenac in Management of Pyrexia in Paediatric Practice Avinash Shankar*1, Amresh Shankar2 and Anuradha Shankar3 1Postgraduate in Endocrinology & Metabolism (AIIMS Delhi), Chairman National Institute of Health & Research Warisaliganj (Nawada), India 2Aarogyam Punarjeevan Ram Bhawan, India 3Centre for Indigenous Medicine & Research Senior Research Fellow Regional Institute of Ayurveda, India Received: : November 19, 2018; Published: : November 28, 2018 *Corresponding author: Avinash Shankar, Postgraduate in Endocrinology & Metabolism (AIIMS Delhi) Chairman National Institute of Health & Research Warisaliganj (Nawada) Bihar, India Abstract Pyrexia, a complex physiological response triggered by infection or aseptic stimuli causes increase in Prostaglandin E2(PGE2)concentration children with pyrexia of varied origin and to calm the temperature at optimal level various therapeutics are in vogue but attendance of children with antipyreticsin brain and adversity later firing presenting rate of neuronesas morbidity of thermoregulatoryand mortality necessiated centre i.e.an evaluationHypothalamus. of presenting Majority hazardsattendance with at consuming paediatrician antipyretics. chamber are of Objective of Study: Analyse the rationality of Aceclofenac paracetamol combination, as antipyretics in paediatric practice. Material & Methods: Analysis of datasheet of patients admitted with antipyretics adversity at Centre For Children Disease & Research. Result: Children consuming Aceclofenac Sodium Paracetamol presented with grave status of prolonged hypothermia, CNS disturbances like Dizziness, Convulsion, coma in addition to more pronounced other presentation like persistant vomiting, haematemesis, blood dyscariasis, rash, albuminuria than other. Conclusion: Acceclofenac sodium Paracetamol combination must be restricted for paediatrics use considering its dreaded outcome.
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • Comparison of Efficacy of Diclofenac Versus Aceclofenac
    The Internet Journal of Orthopedic Surgery ISPUB.COM Volume 19 Number 2 Comparison of Efficacy of Diclofenac versus Aceclofenac in Post Operative Pain in Lower limb fractures: a Double blind, Randomized Study V Sharma, B Awasthi, S Rana, S Sharma Citation V Sharma, B Awasthi, S Rana, S Sharma. Comparison of Efficacy of Diclofenac versus Aceclofenac in Post Operative Pain in Lower limb fractures: a Double blind, Randomized Study. The Internet Journal of Orthopedic Surgery. 2012 Volume 19 Number 2. Abstract INTRODUCTION: Providing effective postoperative analgesia is a significant challenge in patients undergoing orthopedic surgery. Non steroidal anti-inflammatory group of drugs is used mostly to achieve it. This clinical study was done to investigate efficacy of Injectable Aceclofenac over inj. Diclofenac in patients with severe postoperative pain in lower limb fractures. METHODS: 100 patients (aged 18-60 yr) of lower limb fractures were enrolled as per inclusion criteria . They were randomly assigned to Group A or Group B (50 patients each ) .Severe pain was postoperative pain 7 or >7 on Numerical Rating Scale. For postoperative analgesia, in Group A Inj. Aceclofenac ( 12 hourly) and in Group B Inj. Diclofenac (8 hourly) was given . To abort pain in case of no relief Inj. Tramadol was given. Decrease in Numerical Rating Scale score in either the group and associated adverse effects were noted . Patients’ overall subjective response to therapy was rated as poor , fair , good or excellent . RESULTS: After treatment at 10 min. only the mean pain score had 47.8% fall in Group A and 40.3% in Group B.
    [Show full text]