An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Mob3bCyc: Methylosinus trichosporium OB3b Cellular Overview Connections between pathways are omitted for legibility. Author: Katherine Rostkowski, Stanford University

Aminoacyl- C1 Compound Utilization and Assimilation Amine and Polyamine Metabolic Regulator Detoxification tRNA Charging Biosynthesis Respiration respiration (anaerobic) Biosynthesis N-6-isopentenyl superpathway of C1 compounds oxidation to CO a reduced ammonium 2 a sulfurated 37 UQ a peptidoglycan O-phospho- L-glutamine ppGpp biosynthesis superoxide adenosine electron-transfer cys hydroxide glutathionylspermidine [sulfur carrier] L-homoserine biosynthesis II 2-phospho-D-glycerate radicals in tRNA flavoprotein nitrite biosynthesis (tRNA-dependent) methane reductase pppGpp degradation N-acetylmuramoyl- enolase: eno Electron- [NAD(P)H], glutathione spermidine glt superoxide Methane succinate L-alanine Cystathionine transferring- large subunit: Superoxide monooxygenase: dehydrogenase, amidase: gamma- flavoprotein MTRI02239 phosphoenolpyruvate dismutase: MTRI03541 hydrophobic MTRI03674 synthase: glutathionylspermidine dehydrogenase: an L-glutamyl- MTRI01611 membrane MTRI01910 nitrite synthase: MTRI00570 hydrogen MTRI00175 N-acetylmuramoyl- Gln methylamine methanol anchor protein: reductase [tRNA ] peroxide L-alanine pyruvate MTRI03869 Electron- [NAD(P)H], glutamyl-tRNA(Gln) kinase: pvtK amidase: glutathionylspermidine Catalase: transferring- small subunit: amidotransferase, MTRI03675 L-cystathionine GTP ppGpp Pyruvate MTRI00683 flavoprotein MTRI02240 B subunit: gatB oxaloacetate 2-methylthio- kinase: 5'-deoxyadenosine an unsulfurated dehydrogenase: nitrite [+ 2 isozymes] MTRI02411 O N-6-isopentyl met N-acetyl-D- 2 formaldehyde [sulfur carrier] MTRI00695 tRNA charging Nucleoside- adenosine- muramate Peptide an L-glutaminyl- diphosphate 37 tRNA Gln [tRNA ] kinase: pyruvate formaldehyde- an oxidized Phe Gly UQH gly 2 phe a tRNA a tRNA MTRI01595 (S)-malate activating electron-transfer enzyme: flavoprotein glt a tRNA glu fumarate MTRI03339 5,10- phenylalanyl-tRNA glycyl-tRNA GDP hydratase, [+ 2 isozymes] methylenetetrahydrofolate synthetase, alpha synthetase, beta class II: a [protein]-L- an N-modified a supercoiled Lys Trp Cys Thr Ile Met Leu Tyr ser asp His Val Ala Pro Arg Methylenetetrahydrofolate arachidoyl-CoA a lipid II lys a tRNA trp a tRNA cys a tRNA thr a tRNA ile a tRNA met a tRNA leu a tRNA tyr a tRNA ser a tRNA tRNA asp his a tRNA val a tRNA a tRNA ala pro a tRNA arg a tRNA acetyl-CoA formate 5,10-methylene- a malonyl-[acp] β-isoaspartate duplex DNA subunit: pheS subunit: glyS glutamyl-tRNA tRNA Asn gln Gln fumC_II aminoacyl-[tRNA] asn a tRNA tetrahydromethanopterin dehydrogenase Protein-L- replicative phenylalanyl-tRNA glycyl-tRNA synthetase: gltXb citrate (NADP(+)): MTRI03589 isoaspartate(D- fumarate Serine-type DNA lysyl-tRNA tryptophanyl-tRNA cysteinyl-tRNA threonyl-tRNA isoleucyl-tRNA methionyl-tRNA synthetase, beta leucyl-tRNA synthetase, alpha tyrosyl-tRNA seryl-tRNA aspartyl-tRNA histidyl-tRNA glutamyl-tRNA valyl-tRNA alanyl-tRNA prolyl-tRNA arginyl-tRNA synthase I: Aldehyde aspartate) O- 5,10- 3-oxoacyl-(acyl- D-Ala-D-Ala peptidyl- helicase: synthetase: lysSa synthetase: trpS synthetase: cysS synthetase: thrS synthetase: ileS synthetase: metG subunit: pheTb synthetase: leuS subunit: glyQ synthetase: tyrS synthetase: serS synthetase: aspSb synthetase: hisS1 synthetase: gltXb synthetase: valS synthetase: alaS synthetase: proS1 synthetase: argS MTRI00933 dehydrogenase methyltransferase: methenyltetrahydrofolate carrier-protein) carboxypeptidase: tRNA DnaB (NAD(+)): MTRI01436 CO H MTRI03744 5,10-methenyltetrahydromethanopterin S-hydroxymethylglutathione synthase III: fabH MTRI01604 hydrolase: ATP- citrate 2 2 an L-lysyl-[tRNA Lys ] an L-tryptophanyl-[tRNA Trp ] an L-cysteinyl-[tRNA Cys ] an L-threonyl-[tRNA Thr ] an L-isoleucyl-[tRNA Ile ] an L-methionyl-[elongator tRNA Met ] an L-phenylalanyl-[tRNA Phe ] an L-leucyl-[tRNA Leu ] a glycyl-[tRNA Gly ] an L-tyrosyl-[tRNA Tyr ] an L-seryl-[tRNA ser ] an L-aspartyl-[tRNA asp ] an L-histidyl-[tRNA His ] an L-glutamyl-[tRNA Glu ] an L-valyl-[tRNA Val ] an L-alanyl-[tRNA Ala ] an L-prolyl-[tRNA Pro ] an L-arginyl-[tRNA Arg ] an L-asparaginyl-[tRNA Asn ] an L-glutaminyl-[tRNA Gln ] 3-oxoacyl-(acyl- [+ 2 isozymes] protein-L- pth dependent aconitate succinate methenyltetrahydromethanopterin isoaspartate(D- DNA 10-formyl- carrier-protein) hydratase cyclohydrolase: MTRI03336 synthase III: fabH aspartate) O- helicase tetrahydrofolate a N- an N-modified 1: aco 5-formyl- methyltransferase: a tRNA RecQ: S-formylglutathione D-alanine acetylglucosamine- MTRI03956 amino acid tetrahydromethanopterin β recQ_fam cis-aconitate Formate-- -N-acetylmuramyl- a protein L- - a single Tetrapyrrole Biosynthesis coenzyme A tetrahydrofolate a 3-oxodocosanoyl-[acp] (tetrapeptide) isoaspartate stranded DNA Cofactor, Carrier, and Vitamin Biosynthesis aconitate ligase: MTRI03592 pyrophosphoryl- α-methyl ester tetrapyrrole biosynthesis I hydratase undecaprenol adenosylcobalamin biosynthesis II (late cobalt incorporation) superpathway of heme biosynthesis 1: aco adenosylcobalamin biosynthesis I (early cobalt insertion) biotin biosynthesis I superpathway of ubiquinol- ubiquinol-9 biosynthesis superpathway of pyridoxal 5'-phosphate biosynthesis and salvage adenosylcobalamin salvage from cobinamide I from uroporphyrinogen-III tetrapyrrole formate 8 biosynthesis (prokaryotic) (prokaryotic) biosynthesis II D-threo-isocitrate ditrans,octacis UDP-N- glt NAD + a nucleoside uroporphyrinogen-III D-erythrose- -undecaprenyl acetylmuramoyl- NADPH RNA citrate carbonic acid uroporphyrinogen-III malonyl-CoA all-trans- cobinamide glutamyl-tRNA uroporphyrinogen-III methanol triphosphate (2E,6E)-farnesyl isocitrate γ nonaprenyl 4-phosphate gly oxidation to phosphate L-alanyl- -D- diphosphate 4-hydroxybenzoate synthetase: gltXb dehydrogenase, chorismate diphosphate uroporphyrinogen 5-aminolevulinic formaldehyde II glutamyl-L-lysyl- glutamyl-tRNA NADP- CO NAD(P)(+) Citrate (pro-3S)- Carbonate malonyl-CoA decarboxylase: hemE acid synthase: 2 D-alanyl-D-alanine DNA- synthetase: gltXb dependent: idh1 methanol transhydrogenase lyase: MTRI03467 dehydratase: methyl ester 4-hydroxybenzoate an L-glutamyl-[tRNA Glu ] MTRI02263 phospho-N- directed RNA precorrin-1 erythronate- (AB-specific) Citrate (pro-3S)- MTRI03466 precorrin-1 polyprenyl adenosylcobinamide coproporphyrinogen III 5-amino-levulinate acetylmuramoyl- polymerase, all-trans- 4-phosphate 2-oxoglutarate : MTRI03418 lyase: MTRI03584 [+ 3 isozymes] transferase: ubiA pentapeptide- beta' subunit: 4-hydroxybenzoate octaprenyl Porphobilinogen formaldehyde transferase: mraY NAD(P)(+) MTRI02623 diphosphate oxygen-independent synthase: formaldehyde assimilation I (serine pathway) nonaprenyl-4- transhydrogenase [+ 3 isozymes] a 3-oxoglutaryl- coproporphyrinogen MTRI01637 N-acetylmuramoyl-L- acetate oxaloacetate CO H O (AB-specific) 2 2 precorrin-2 [acp] methyl ester 4-hydroxybenzoate hydroxybenzoate 2-oxo-3-hydroxy-4- adenosyl-cobinamide glutamate-1-semialdehyde III oxidase: MTRI02338 γ UMP precorrin-2 aerobic respiration (alternative oxidase pathway) formaldehyde alanyl- -D-glutamyl-L- : MTRI03420 polyprenyl phosphobutanoate phosphate nicotinate protoporphyrinogen IX porphobilinogen Nucleoside 5,6-dimethylbenzimidazole oxygen-independent lysyl- D-alanyl-D-alanine- precorrin-2 C20- transferase: ubiA mononucleotide and Nucleotide RNA Adenosylcobinamide- coproporphyrinogen diphosphoundecaprenol methyltransferase: UbiA porphobilinogen NAD + Degradation phosphate III oxidase: hemN NADH NADP + cobI_cbiL a (3R)-3- prenyltransferase: 2-nonaprenylphenol deaminase: hemC adenosine hydroxyglutaryl- 4-phospho- guanylyltransferase: 5-amino-levulinate UQH 5,10- MTRI00242 2 nucleotides precorrin-3A cobalt-precorrin-2 MTRI01382 methylenetetrahydrofolate [acp] methyl ester hydroxy-L-threonine protoporphyrinogen IX hydroxymethylbilane degradation II Porphobilinogen N-acetylmuramoyl-L- a protein with a (3R,11Z)-3- precorrin-3B 3-octaprenyl-4- 4-hydroxythreonine- adenosylcobinamide- α-ribazole-5'-phosphate coenzyme A biosynthesis synthase: Uroporphyrinogen gly Glycine a malonyl-[acp] a palmitoleoyl-[acp] alanyl-D-isoglutaminyl- reduced L- hydroxyoctadec- synthase: hydroxybenzoate 3-(all-trans- 4-phosphate GDP AMP ATP a glutamine MTRI01637 III synthase hydroxymethyltransferase: L-lysyl-(glycyl) - cysteine residuesDSBA 11-enoyl-[acp] MTRI04055 a (2E)- nonaprenyl) dehydrogenase: D-4'- 5 synthetase beta- D-glyceraldehyde- HEM4: MTRI00590 MTRI00618 D-alanyl-D-alanine- cobalt-precorrin-3 enoylglutaryl- benzene-1,2-diol pyruvate pdxA phosphopantothenate porphobilinogen NADH-ubiquinone oxidoreductase: hydroxyacyl- 3-phosphate 3-oxoacyl- diphosphoundecaprenyl- MTRI00875 precorrin-3B [acp] methyl ester (2S)-2-amino-3-oxo-4- protoporphyrin IX uroporphyrinogen-III oxidoreductase (acyl-carrier- Uroporphyrin-III R-4'- porphobilinogen [acyl-carrier- N-acetylglucosamine [Glutamate-- DSBA protein) precorrin-3B C17- 2-octaprenylphenol phosphonooxybutanoate adenosylcobalamin chain 4L: adenosine C/tetrapyrrole deoxyxylulose- phosphopantothenoyl- deaminase: hemC ferrochelatase: an oxidized glyoxylate ser protein] ammonia-ligase] oxidoreductase: dehydratase methyltransferase: 2-methoxy- 5'-phosphate MTRI00822 H O (Corrin/Porphyrin) 5-phosphate L-cysteine hemH ferroprotein (Fe III) 2 synthase 2: Peptidoglycan adenylyltransferase: MTRI01734 FabZ: fabZ cobJ_cbiH 2-polyprenylphenol 6-(all-trans- a (2E,11Z)- methyltransferase: synthase: dxs hydroxymethylbilane MTRI02540 glycosyltransferase: MTRI03489 a protein with a glutaryl-[acp] 6-hydroxylase: UbiB nonaprenyl)phenol octadeca-2,11- MTRI00504 3-amino-1- protoheme IX MTRI03791 a disulfide bond precorrin-4 methyl ester 3-(all-trans dienoyl-[acp] 1-deoxy-D-xylulose hydroxyacetone- Uroporphyrinogen adenylyl- 3-oxoacyl- -octaprenyl) III synthase an (11Z)-3- precorrin-4 C11- cobalt-precorrin-4 5-phosphate 1-phosphate coenzyme B 4'-phosphopantetheine [glutamine [acyl-carrier- benzene-1,2-diol 12 HEM4: MTRI00590 acetyl-CoA hydroxypyruvate inosine oxooctadec- acyl-carrier protein a peptidoglycan di-trans,octa-cis methyltransferase: 2-methoxy-6-all synthase] protein] 3-demethylubiquinone- 11-enoyl-[acp] dimer (S. aureus) -undecaprenyl cobM_cbiF trans-nonaprenyl- pyridoxal pantetheine- synthase 2: 9 3-methyltransferase: uroporphyrinogen-III NADH diphosphate 2-methoxy-1,4- phosphate phosphate precorrin-5 MTRI02540 MTRI02813 biosynthetic pyridoxine adenylyltransferase: cobalt- 2-methoxy- benzoquinol pyridoxamine β N 2 acetyl-α- precorrin-5A a 3-oxopimeloyl- protein S-adenosyl-L- MTRI01570 4-( -D- N-acetylmuramoyl-L- a (3R)-3- precorrin- 6-(all-trans- (S)-malyl-CoA D-glycerate a malonyl-[acp] an acyl-[acyl- aminoadipyl- [acp] methyl ester PdxJ: pdxJ methionine biosynthesis fumarate ribofuranosyl) 6-hydroxymethyl- alanyl-D-isoglutaminyl- hydroxyhexacosanoyl- 6A synthase octaprenyl)phenol dephospho-CoA hypoxanthine carrier protein] β δ-phosphate aminobenzene- dihydropterin N-( -D-asparatyl)-L- [acp] beta- N-acetyl- (deacetylating) 6-methoxy-3- 5'-phosphate diphosphate lysyl-D-alanyl-D-alanine- methyl-2-all- dephospho- hydroxyacyl- gamma- : MTRI04064 cobalt- pyridoxamine ATP diphosphoundecaprenyl- trans-nonaprenyl- pyridoxine-5'-phosphate met CoA kinase: Polyprenyl Biosynthesis 3-oxoacyl- asparagine (acyl-carrier- glutamyl- precorrin-5B a (3R)-3- 2-methoxy-6-all 5'-phosphate [acyl-carrier- N-acetylglucosamine precorrin-6A 1,4-benzoquinol MTRI03476 2-phospho- dihydropteroate synthase: protein) phosphate hydroxypimeloyl- trans-octaprenyl- (S)-malate pyridoxal trans, trans-farnesyl protein] MTRI00562 dehydratase reductase: 2-methoxy-1,4- enolase:D-glycerate synthase: dhps N-acetylmuramoyl-L- precorrin-6x [acp] methyl ester pyridoxamine pyridoxamine S-adenosylmethionine coenzyme A di-trans,poly-cis xanthine synthase 2: 2 diphosphate biosynthesis succinate a reduced [+ 2 isozymes] FabZ: fabZ N -acetyl-argCα- reductase: benzoquinol 5'-phosphate 5'-phosphate synthetase: metK -undecaprenyl O eno MTRI02540 alanyl-D-isoglutaminyl- a (2E)-hexacos- cobalt- dehydrogenase, ferroprotein (Fe II) 2 aminoadipate pcr oxidase: pdxH oxidase: pdxH isopentenyl phosphate biosynthesis 3-phospho- 7,8-H pterin-6- N-(β-D-asparaginyl)-L- 2-enoyl-[acp] precorrin-6A 3-demethylubiquinol-9 cytochrome 2 semialdehyde diphosphate (2E,6E)-farnesyl D-glycerate yl-methyl-4-(β- lysyl-D-alanyl-D-alanine- a (2E)- b556 subunit: precorrin-6B superpathway of tetrahydrofolate biosynthesis and salvage SAM phosphoenol D-ribofuranosyl) diphosphoundecaprenyl- enoylpimeloyl- 6-methoxy-3- diphosphateundecaprenyl oxaloacetate acyl-carrier protein a 3-oxoacyl-[acp] pyridoxal-P MTRI03870 pyruvate urate aminobenzene N-acetylglucosamine precorrin-6Y C5,15- [acp] methyl ester methyl-2-all- dimethylallyl diphosphate 5'-phosphate methyltransferase cobalt- trans-octaprenyl- adenosylcobalamin diphosphate di-trans,octa-synthase:cis uppS (decarboxylating) precorrin-6B 1,4-benzoquinol ubiquinol-9 GTP salvage from cobalamin -undecaprenyl , CbiT subunit: diphosphate GlcNAc-MurNAc- a (3R)-3- a pimeloyl-[acp] cob(I)alamin a (7Z)-tetradec- a uracil in DNA MTRI04060 GTP folate transformations II UQ a malonyl-[acp] pentapeptide hydroxytetracosanoyl- methyl ester cob(I)alamin 7-enoyl-[acp] dGMP cyclohydrolase geranyl [acp] beta- precorrin-8x 3-demethylubiquinol-8 adenosyltransferase: succinate cobalt-precorrin-7 I: folE 7,8-dihydrofolate diphosphate lytic murein hydroxyacyl- guanylate 7,8- cobA uracil-DNA Precorrin-8X monoglutamate 3-oxoacyl- transglycosylase: (acyl-carrier- kinase: 3-demethylubiquinone- dihydroneopterin coenzyme B Geranyltranstransferase: glycosylase: methylmutase: 9 3-methyltransferase: 12 [acyl-carrier- MTRI00064 protein) MTRI02537 triphosphate MTRI02334 aerobic respiration (cytochrome c) Amine and Polyamine Degradation ung MTRI04056 a pimeloyl-[acp] MTRI02813 protein] lytic murein dehydratase (2E,6E)-farnesyl synthase 2: dGDP cobalt- transglycosylase: an AP (apurinic FabZ: fabZ hydrogenobyrinate ubiquinol-8 diphosphate creatinine MTRI02540 uracil a (2E)-tetracos- precorrin-8x 8-amino-7- NADH MTRI00995 or apyrimidinic) 7,8- degradation I urea degradation I 4-aminobutyrate urea oxononanoate 2-enoyl-[acp] Cobyrinic dihydroneopterin UQ degradation II degradation II site created acid ac- synthase: Glycine a (9Z)-3- a peptidoglycan GlcNAc-1,6- by glycosylic 3'-phosphate creatinine urea diamide MTRI03667 hydroxymethyltransferase: 4-aminobutyrate urea oxohexadec- acyl-carrier protein polymer with anhydro-MurNAc- bond cleavage Creatininase: urea synthase: cobyrinate MTRI00618 urease, alpha 9-enoyl-[acp] GlcNAc end tetrapeptide 8-amino-7- 5,10- MTRI00584 amidolyase MTRI03484 tetrahydrofolate subunit: ureC oxononanoate methylenetetrahydrofolate related 7,8-dihydro- creatine succinate [+ 2 isozymes] [+ 4 isozymes] synthase: flavin biosynthesis I (bacteria and plants) protein: an N-acetyl-β- a (3R)-3- chorismate NADH-ubiquinone semialdehyde + MTRI01498 D-neopterin ammonia a ceramide UDP-D-glucose NAD(P) FMNH hydrogenobyrinate oxidoreductase MTRI00608 D-hexosaminide 2 hydroxyoctadecanoyl- met cob(II)yrinate dihydroneopterin para- succinic a,c-diamide 7-keto-8- chain 4L: urea-1-carboxylate [acp] beta- methionine- a,c-diamide aldolase: semialdehyde cobalt aminopelargonate GTP aminobenzoate R-sulfoxide MTRI02962 5,10- O a reduced c-type cytochrome MTRI00822 dehydrogenase: ceramide Beta-N- NADPH- hydroxyacyl- cob(II)yrinic synthase, 2 Allophanate chelatase, adenosylmethionine- methylenetetrahydrofolate acetylhexosaminidase: (acyl-carrier- reductase: acid a,c- 6-hydroxymethyl- subunit I: pabB sarcosine hydrolase ssadh glucosyltransferase: dependent pCobS 8-amino-7- GTP reductase: fadh2 MTRI02638 FMN protein) MTRI03593 diamide 7,8-dihydropterin 4-amino-4- subunit 1: MTRI02582 L-methionine- small oxononanoate cyclohydrolase succinate Beta-N- reductase: dehydratase reductase: 2-amino-4-hydroxy-6- deoxychorismate MTRI00607 Ceramide (R)-S-oxide subunit: aminotransferase: bioA II: MTRI04248 acetylhexosaminidase: MTRI02142 FabZ: fabZ MTRI01506 2,5-diamino-6- hydroxymethyldihydropteridine glucosyltransferase: cobS 7,8- aminodeoxychorismate 5-methyl- ammonia MTRI00651 a (2E)-octadec- (5-phospho-D- pyrophosphokinase: folK MTRI00102 [+ 3 isozymes] cob(I)yrinate diaminopelargonate lyase: MTRI02539 tetrahydrofolate Amino Acid Degradation 2-enoyl-[acp] ribosylamino) 6-hydroxymethyl- a,c-diamide ubiquinol- + gly + cob(II)yrinate dethiobiotin cytochrome c NAD β FMN NAD(P)H H pyrimidin- dihydropterin Formate-- a D-glucosyl-N- an N-acetyl- - H + MTRI01755 H + cob(I)alamin synthase: 4-aminobenzoate cytochrome c UDP Rh a,c-diamide 4(3H)-one diphosphate tetrahydrofolate oxidase subunit lysine fermentation to acylsphingosine D-hexosamine adenosyltransferase: bioD reductase, iron- isoleucine degradation I cob(II)yrinic ligase: MTRI03592 III: MTRI00743 acetate and butyrate histidine degradation II cobA sulfur subunit: acid a,c- dihydropteroate [+ 6 isozymes] succinate adenosyl- dethiobiotin 10-formyl- MTRI01848 a [TusE sulfur a 2'- a [pyruvate a (3R)-3- an [RNA]-3'- diamide synthase: dhps superpathway of thiamin diphosphate biosynthesis I + + cobyrinate 5-amino-6-(5- Cofactor, Prosthetic Group, lys ile his carrier protein]-S a uridine 34 in tRNA ribonucleoside- H MTRI03420 H reductase: biotin tetrahydrofolate deoxyribonucleoside [DNA] dehydrogenase hydroxydocosanoyl- a,c-diamide phospho-D- 5,10- Electron Carrier Degradation 6 7,8- -sulfanylcysteine 5'-triphosphate E2 protein] N [acp] 3'-phosphateRNA 3'- MTRI01506 synthase: D-ribulose- ribosylamino)uracil methenyltetrahydrofolate a ThiS sulfur- branched-chain beta- cobyric -dihydrolipoyl- phosphate cob(I)yrinate bioB 5-phosphate dihydropteroate Methylenetetrahydrofolate carrier protein vitamin B degradation amino acid dihydrolipoamide hydroxyacyl- acid cys 6 urocanate L-lysine dehydrogenase tRNA (5- DNA (acyl-carrier- cyclase: H + MTRI03418 + a,c-diamide synthase biotin 3,4- 5,10- aminotransferase: dehydrogenase: H (NADP(+)): MTRI03589 (3S)-3,6- methylaminomethyl- polymerase protein) an [RNA]-3'-MTRI04287 cob(I)alamin CobQ: dihydroxy-2- methenyltetrahydrofolate succinate pyridoxamine pyridoxine ilvE_I MTRI00519 5-amino-6-(5- 10-formyl- H O an oxidized c-type cytochrome diaminohexanoate 2-thiouridylate)- III, beta dehydratase ribonucleoside-2',3'- adenosyltransferase: cobQ butanone 4- 7,8-dihydrofolate 2 dehydrogenase, 2-keto-3- dihydrolipoamide (R)-1-amino- phospho-D- tetrahydrofolate a carboxy- methyltransferase: subunit: dnaN FabZ: fabZ cyclophosphate cobA phosphate monoglutamate cytochrome methyl-valerate dehydrogenase: 2-propanol O ribitylamino)uracil a [ThiI sulfur- adenylated- 4-imidazolone- trmU [+ 8 isozymes] a [pyruvate a (2E)-docos- adenosyl- adenosyl-cobyrate synthase: 5-formyltetrahydrofolate D-glyceraldehyde- b556 subunit: dehydrogenaseMTRI03609 2-enoyl-[acp] cobyrinate -2-phosphate phosphoribosylglycinamide cyclo-ligase: MTRI00655 carrier protein]-S [ThiS sulfur- 5-propionate ribB MTRI03870 (3S,5S)-3,5- 6 thioredoxin formyltransferase: PurN 3-phosphate -sulfanylcysteine carrier protein] E2 protein] N a,c-diamide 1-deoxy-L- tyr diaminohexanoate a 2-thiouridine 34 a [TusE sulfur carrier pathway deoxyxylulose- pyridoxal [DNA] -lipoyl-L-lysine cobyric glycero-tetrulose 5-amino-6-(D- 2-methylbutanoyl- in tRNA protein]-L-cysteine 5-formyl- 5-phosphate acid an oxidized 4-phosphate ribitylamino)uracil molybdenum cofactor biosynthesis I tetrahydrofolate 5-amino-1-(5- Pyridoxal 4- CoA adenosyl- tetrahydrofolate synthase: dxs N-formimino- synthase thioredoxin phospho-D- dehydrogenase: cobinamide a small subunit of 1-deoxy-D- L-glutamate a [protein]-L- a (3R)-3- CobQ: 6,7-dimethyl-8- NAD salvage pathway I ribosyl)imidazole a thiocarboxy- UQH MTRI02418 (S)-5-amino-3- a [protein]- FMNH phosphate molybdopterin Fermentation mixed acid fermentation 2 an acetylated 5 2 xylulose 5- glutamate-O hydroxydocosanoyl- L-histidine cobQ 5,6-dimethylbenzimidazole ribityllumazine 2-iminoacetate [ThiS-Protein] oxohexanoate (E)-2- dGTP histone (R)-1-amino- Adenosylcobinamide- synthase phosphate 4-pyridoxolactone -methyl-ester [acp] Histidine thioredoxin synthase: ribH nicotinamide fumarate methylcrotonoyl- beta- adenosyl-cobyrate 2-propanol O phosphate phosphoenolpyruvate kinase: reductase: CoA hydroxyacyl- -2-phosphate guanylyltransferase: 4-amino-2-methyl-5- MTRI03147 trxr 6,7-dimethyl-8-(1- Fatty Acid and Lipid Biosynthesis N-formyl- Histone Protein-glutamate (acyl-carrier- MTRI01382 phosphomethylpyrimidine deoxyguanosinetriphosphate [+ 2 isozymes] 5,6-dimethylbenzimidazole D-ribityl)lumazine a carboxy- pyruvate L-glutamate deacetylase: methylesterase: protein) a [protein]- adenosylcobinamide- α-ribazole- 2-[(2R,5Z)- L-3-aminobutyryl-CoA acetoacetate triphosphohydrolase: riboflavin adenylated phosphomethylpyrimidine kinase: pvtK N-formylglutamate MTRI00629 MTRI02179 dehydratase N-phospho- GDP 5'-phosphate + (2-carboxy-4- palmitate biosynthesis 4-pyridoxate 2-methyl-3- MTRI00021 synthase, [small subunit of NAD kinase: MTRI03412 lipid IV biosynthesis CDP-diacylglycerol [+ 2 isozymes] [+ 2 isozymes] FabZ: fabZ L-histidine adenosyl- a reduced methylthiazol-5(2H II (bacteria and plants) A Pyruvate amidohydrolase: molybdopterin biosynthesis I oxaloacetate hydroxybutyryl- a (2E)-docos- cobinamide thioredoxin alpha 4-amino-2-methyl-5- kinase: MTRI01674 synthase] GTP )-ylidene]ethyl a (3R)-3- CoA 2-enoyl-[acp] phosphate subunit: ribE MTRI02411 α-ribazole- diphosphomethylpyrimidine phosphate an acetoacetyl-[acp] hydroxytetradecanoyl- α dihydroxyacetone PPP a [protein]- UDP- -N-acetyl- glt i 6 a deacetylated methanol Adenosylcobinamide- phosphate crotonyl-CoA deoxyguanosine N -acetyl-L-lysine L-glutamate 5'-phosphate riboflavin [acp] D-glucosamine 5-formyl-3-hydroxy-2- histone phosphate adenosylcobalamin Glycerol-3- pyruvate methylpyidine-4-carboxylate guanylyltransferase: 5'-phosphate a thiocarboxylated phosphate 2-methylacetoacetyl- acyl-[acyl-carrier- dehydrogenase (S)-malate MTRI01382 NAD biosynthesis [small subunit of CoA protein]--UDP-N- (NAD(P)(+)) (1S,2R)-1- a (3R)-3- I (from aspartate) adenosylcobalamin salvage from cobinamide II molybdopterin cyclic pyranopterin thiamin phosphate fumarate a [protein]-L- adenosylcobinamide- α biotin biosynthesis II a (3R)-3- acetylglucosamine O- a RNA-DNA hybrid -ribazole monophosphate nicotinate adenine nicotinamide epoxysqualene : MTRI03710 butanoyl-CoA IMP ser C-(indol-3- hydroxyicosanoyl- methionine GDP FMN synthase] hydroxybutanoyl-[acp] acyltransferase: lpxA sn-glycerol- hydratase, 3-hydroxy-2-methylpyridine- glutamine dinucleotide mononucleotide thiamine- biosynthesis yl)glycerol [acp] beta- methionine- asp coenzyme B cobinamide 3-phosphate class II: 4,5-dicarboxylate degradation II 12 pimelate beta- (R)-lactate 3-phosphate R-sulfoxide molybdopterin nicotinate monophosphate UDP-3-O-[(3R)-3- fumC_II hydroxyacyl- hydroxyacyl- (2E,6E)-farnesyl formate acetyl-CoA acetyl-CoA propanoyl-CoA ribonuclease reductase: L-aspartate biosynthesis kinase: thiL hydroxymyristoyl]-N (acyl-carrier- (nicotinamide) diphosphate gln Xanthine tryptophan H: MTRI02574 MTRI03593 oxidase: nadB MoaE protein: (acyl-carrier- α squalene fumarate protein) a protein-L- nucleotide thiamin - -acetylglucosamine L-glutamate:NADP+ synthase, Ribonuclease coenzyme B α-iminosuccinate FAD MTRI01135 pimeloyl-CoA protein) UDP-3-0-acyl N- citrate 3-hydroxy-2-methylpyridine- phosphoribosyltransferase: 12 diphosphate synthase a 1-acyl-sn acetoacetyl-CoA n-butanoate dehydratase methionine- adenylyltransferase: oxidoreductase MTRI01093 beta H: MTRI00080 dehydratase acetylglucosamine HpnC: -glycerol 3- synthase I: 5-carboxylate FabZ: fabZ (R)-S-oxide adenosylcobinamide MTRI02943 (transaminating) subunit: trpB 8-amino-7- FabZ: fabZ deacetylase: lpxC MTRI03682 phosphate MTRI00933 acetyl-CoA a (2E)-icos- molybdopterin oxononanoate CO H acetaldehyde acetyltransferase: tyrosine degradation I : gltB gltD nicotinate UDP-3-O-(3- 2 2 acetylphosphate 5-phospho- a nucleoside 5'- 2-enoyl-[acp] nicotinamide squalene D-glyceraldehyde- DNA mononucleotide synthase: MTRI03667 a (2E)-but-2-enoyl-[acp] hydroxymyristoyl) succinate MTRI03447 Glutamate synthase α-D-ribose 1- synthase citrate hypoxanthine 3-phosphate trp monophosphate phosphopantothenate biosynthesis I quinolinate (R)-1-amino- 8-amino-7- -α-D-glucosamine 2-(acetamidomethylene) (NADPH): MTRI00803 diphosphate HpnD: a 1,2-diacyl- acetate [+ 2 isozymes] tyr 2-propanol O oxononanoate UDP-3-O-[3- succinate glt nicotinate-nucleotide adenosyl-cobyrate MTRI03683 sn-glycerol kinase: ackA aconitate -2-phosphate adenylyl- synthase: MTRI01498 hydroxymyristoyl] presqualene acetyl-CoA 2-oxoisovalerate pyrophosphorylase: nicotinate 3-phosphate ethanol hydratase 5,6-dimethylbenzimidazole molybdopterin glucosamine N- diphosphate pyruvate fermentation acetate 1: aco a [protein]- a 3'-half-tRNA nadC mononucleotide nicotinate phosphatidate 4-hydroxyphenylpyruvate 4-amino-2-methyl-5- 4-methyl-5-(2- O-acetyl-L- S-methyl-L- 3-methyl-2-oxobutanoate 7-keto-8-aminopelargonate acyltransferase: lpxD to butanoate cys L-homocysteine L-tyrosine molecule with nicotinate phosphoribosyltransferase: a butanoyl-[acp] UDP-2,3-bis[O-(3R)- squalene cytidylyltransferase: diphosphomethylpyrimidine phosphonooxyethyl)thiazole homoserine methionine hydroxymethyltransferase: adenosylmethionine-8- cis-aconitate succinate semialdehyde phosphate a 5'-OH end mononucleotide adenosyl- MTRI03624 3-hydroxymyristoyl]- synthase MTRI01772 pyruvate 4-hydroxyphenylpyruvate Protein-tyrosine- 2'-5' RNA panB amino-7-oxononanoate 3-oxoacyl- nicotinate cobinamide molybdenum α-D-glucosamine HpnC: a CDP- aconitate acetylphosphate dioxygenase: 4HPPD thiamine phosphatase: ligase: nicotinate aminotransferase: bioA (acyl-carrier- MTRI03682 hydratase Cystathionine homocysteine S- 2-dehydropantoate (nicotinamide) phosphate α-ribazole- cofactor diacylglycerol (R)-acetoin monophosphate MTRI02669 MTRI01474 protein) biosynthesis I 1: aco homogentisate gamma- methyltransferase: nucleotide Adenosylcobinamide- 5'-phosphate 7,8-diaminopelargonate squalene acetate synthase: MTRI00086 Protein-tyrosine- 2-dehydropantoate folate transformations I synthase acetyl-CoA synthase: MTRI03561 a ligated tRNA adenylyltransferase: phosphate 2,3-bis[(3R)-3- synthase Secondary Metabolite kinase: ackA thiamine-phosphate phosphatase: 2-reductase: γ-glutamyl cycle III: fabH pyruvate D-threo-isocitrate homogentisate 1,2- MTRI01910 MTRI02943 guanylyltransferase: dethiobiotin hydroxymyristoyl]- HpnD: acetyl-CoA Degradation pyrophosphorylase: thiE MTRI01701 apbA_panE [+ 2 isozymes] acetate dioxygenase: hmgA a [protein]- nicotinate adenine MTRI01382 tetrahydrofolate synthase: bioD α MTRI03683 acetyltransferase: acetolactate isocitrate -D-glucosaminyl L-tyrosine β-alanine MTRI03447 synthase, dehydrogenase, N-acetylglucosamine met (R)-pantoate dinucleotide adenosylcobinamide- α-ribazole glutathione a 3-oxohexanoyl-[acp] 1-phosphate 4-maleyl-acetoacetate acetate dethiobiotin squalene large subunit, degradation II L-cystathionine NAD+ GDP lipid-A- [+ 2 isozymes] NADP- thiamin phosphate biosynthetic β synthetase: gamma- dependent: idh1 N-acetyl- -D- maleylacetoacetate Formate-- disaccharide acetoacetyl-CoA type: acolacL nadE biotin synthase: bioB glutamyltransferase: glucosamine isomerase: maiA tetrahydrofolate synthase: lpxB 2-oxoglutarate methionine degradation MTRI01393 acetolactate + ligase: MTRI03592 lipid A (3S)-2,3- 3-hydroxyacyl- I (to homocysteine) NAD synthase, N-acetyl-D- 4-fumaryl-acetoacetate pyruvate NADPH NAD + a peptide with a an acyl-CoA H O a ribonucleoside NAD biosynthesis III a (3R)-3- 2 (R)-pantothenate acyl carrier coenzyme B biotin disaccharide epoxy-2,3- CoA 12 small subunit: glucosamine leader sequence diphosphate protein metabolism 10-formyl- hydroxyhexanoyl-[acp] dihydrosqualene dehydrogenase L-ascorbate tetraacyldisaccharide acolacS 6-phosphate met fumarylacetoacetate (FAA) Nucleoside- pantothenate lipoate tetrahydrofolate glutathione NAD-binding: biosynthesis V nicotinamide beta- 4'-kinase: lpxK (S)-2-acetolactate N-acetylglucosamine- hydrolase: MTRI00754 pyruvate, putative NAD(P) acyl-CoA diphosphate kinase: panKb biosynthesis and Nicotinamide synthetase: MTRI02980 (S)-acetoin S-adenosylmethionine signal acyl-carrier protein hydroxyacyl- 6-phosphate fumarylacetoacetate (FAA) phosphate transhydrogenase thioesterase: kinase: MTRI02222 lipid IV (S)-3- biosynthesis synthetase: metK D-4'- D-sorbitol incorporation I phosphoribosyltransferase: α γ A peptidase I: MTRI01595 NAD γ an -( -L- (acyl-carrier- deacetylase: nagA hydrolase: MTRI03573 dikinase: subunit alpha part MTRI00908 MTRI04331 L- - cysteinylglycine CDP-diacylglycerol hydroxybutanoyl- SAM MTRI03347 a ribonucleoside phosphopantothenate phosphorylation and nicotinamide glutamyl)-L- protein) D-glucosamine MTRI00980 2 transmembrane an octanoyl-[acp] 5,10- glutamylcysteine biosynthesis II CoA pyruvate fumarate triphosphate amino acid dehydratase 6-phosphate protein: MTRI03419 dephosphorylation lipoate- holo-acyl-carrier- mononucleotide methenyltetrahydrofolate acetolactate L-sorbopyranose FabZ: fabZ dihydroxyacetone diacetyl a carboxylate NAD + protein protein synthase: acpS synthase, phosphoenol 5-formyltetrahydrofolate glycine cleavage complex + a leader sequence Peptide ligase phosphatidylethanolamine phosphate diphosphate H 4'-phosphopantetheinyl cyclo-ligase: MTRI00655 Glycerol-3- large subunit, AMP pyruvate a [lipoyl-carrier a (2E)-hex-2-enoyl-[acp] NADH NADP + B: lipB transferase: MTRI04150 Glycine biosynthesis I phosphate crotonyl-CoA biosynthetic D-fructose- S-adenosyl-L- a [glycine-cleavage NAD(P)(+) protein] N 6 - + Methylenetetrahydrofolate 5-formyl- cys 6 NAD hydroxymethyltransferase: gly dehydrogenase type: acolacL 6-phosphate homocysteine complex H protein] N Glycine L-sorbosone transhydrogenase dehydrogenase tetrahydrofolate guanylyl molybdenum octanoyl-L-lysine MTRI00618 a CDP-diacylglycerol (NAD(P)(+)) (R)-acetoin -[(R)-lipoyl]-L-lysine dehydrogenase (AB-specific) lipoic acid (NADP(+)): MTRI03589 cofactor biosynthesis acetolactate adenosylhomocysteinase: : MTRI03710 dihydrolipoamide (decarboxylating) S-methyl-5'- : MTRI03418 synthetase: an acyl-carrier protein synthase, ahcY stearoyl-CoA a ferrocytochrome sn-glycerol- molybdenum sn-glycerol- dehydrogenase: : MTRI03364 a PII protein thioadenosine lipA a 3-sn-phosphatidyl- small subunit: b 3-phosphate ATP NAD(P)(+) 5-methyl- 5,10- cofactor a hexanoyl-[acp] 3-phosphate butanoyl-CoA 5 UTP L-sorbosone a lipoylated molybdopterin- acolacS MTRI00519 Glycine anaerobic transhydrogenase tetrahydrofolate methylenetetrahydrofolate L-serine L-homocysteine 1,4-lactone protein guanine glt 5-oxoproline Phosphate (S)-2-acetolactate dihydrolipoamide dehydrogenase methylthioadenosine glycerol-3- adenylate (AB-specific) 3-oxoacyl- phosphatidylserine fatty acid L-sorbosone lipoyl-domain dinucleotide butyryltransferase: dehydrogenase: (decarboxylating) protein-P-II phosphorylase: phosphate cyclase: : MTRI03420 5,10- [acyl-carrier- decarboxylase desaturase: biosynthesis a 1-acyl-sn MTRI02926 MTRI03609 : MTRI03365 uridylyltransferase: MTRI01805 dehydrogenase MTRI02321 dehydrogenase: methylenetetrahydrofolate protein] related protein: a [glycine-cleavage MTRI03071 MTRI00015 protein A: -glycerol 3- a [glycine-cleavage glnD subunit C: cyclic-AMP reductase: fadh2 synthase 2: MTRI01211 butanoyl complex H protein] N 6 - MTRI01681 6 [+ 2 isozymes] MTRI00624 guanylyl MTRI02540 phosphate phosphate complex H protein] N S-methyl-5- L-ascorbate an L-1- diacetyl aminomethyldihydrolipoyl- dihydroxyacetone + molybdenum -dihydrolipoyl-L-lysine α NADP [+ 2 isozymes] L-lysine a uridylylated thio- -D-ribose phosphate phosphatidylethanolamine phenylalanine degradation I (aerobic) a ferricytochrome adenine cofactor oleoyl-CoA PII protein 1-phosphate b a 3-oxooctanoyl-[acp] a 1,2-diacyl- 5 sn-glycerol a tetrahydrobiopterin n-butanoate phenylalanine- 3-phosphate (S)-acetoin glycine cleavage phosphatidate 4-hydroxylase: a [protein]-L- phe system T (R)-lactate an oxidized c- menadione NADH H + H + bicarbonate cytidylyltransferase: MTRI00074 proline (ω = 180) a protein protein: gcvT type cytochrome PpiC-type a (3R)-3- MTRI01772 ATP- peptidyl-prolyl histidine biosynthesis Amino Acid Biosynthesis hydroxyoctanoyl-[acp] a CDP- pyruvate fermentation to propionate I NADH-quinone Carbonate dependent superpathway of leucine, valine, and isoleucine biosynthesis lysine biosynthesis I arginine biosynthesis I alanine homocysteine biosynthesis tyr D-lactate cis-trans superpathway of serine phenylalanine diacylglycerol pyruvate protease biosynthesis I beta- α dehydrogenase oxidoreductase, dehydratase: isomerase: 5-phospho- and glycine biosynthesis I biosynthesis I fermentation a 7,8-dihydrobiopterin 4 -hydroxy- La: lon hydroxyacyl- oxaloacetate citrulline degradation (cytochrome) F subunit: nuoF MTRI03466 MTRI03491 α-D-ribose 1- pyruvate tetrahydrobiopterin thr asp glt 3-phospho- 2-oxoisovalerate L-homoserine to lactate [+ 2 isozymes] [+ 3 isozymes] Peptide diphosphate chorismate (acyl-carrier- : MTRI01009 [+ 4 isozymes] D-glycerate protein) acyl-CoA hydrolysis pyruvate a [protein]-L- ATP acetolactate aspartate D-3- chorismate homoserine O- L-citrulline kinase: aspK homoserine and phosphoglycerate dehydratase proline (ω = 0) phosphoribosyltransferase: synthase, mutase: acetyltransferase: biotin-carboxyl carrier a reduced c- + FabZ: fabZ a 2,3,4-saturated ornithine pyruvate menadiol NAD CO H O hisG large subunit, L-aspartyl-4-phosphate methionine biosynthesis dehydrogenase: MTRI00132 val hsat protein assembly type cytochrome 2 2 fatty acyl CoA transcriptional carbamoyltransferase: otc phosphoribosyl- biosynthetic pgdh chorismate (S)-methylmalonyl- (S)-lactate carbamoyl- 2-oxobutanoate N-acetyl-L- 3-phospho- O-acetyl-L- a (2E)-oct-2-enoyl-[acp] (S)-malate coactivator/pterin ATP type: acolacL asp mutase: biotin carboxyl- acyl-CoA CoA phosphate aspartate- glutamate hydroxypyruvate homoserine hydrogen sulfide fumarate dehydratase: acetolactate MTRI01641 carrier protein thioesterase: a [protein]- phosphoenol 5-(methylthio)- RNase II phosphoribosyl- semialdehyde phosphoserine methylmalonyl- hydratase, MTRI03972 O ubiquinol-8 acetylglutamate aspartate arginine degradation prephenate MTRI00908 2 pyridoxal-P D-alanine 2,3-dioxopentyl degradation ATP synthase, dehydrogenase: aminotransferase: CoA epimerase: alanine L-histidine pyruvate kinase: I (arginase pathway) class II: phosphate substrate mRNA diphosphatase: small subunit: 2-aceto-2- MTRI02523 kinase: argB serC_2 ala degradation IV 2,3-diketo-5- aspK Prephenate MTRI00828 fumC_II Macromolecule Modification MTRI00363 acolacS a 2,3,4-saturated CO methylthio-1- ribonuclease hydroxy- L-aspartate- N-acetylglutamyl- dehydratase: coenzyme A 2 phosphoenolpyruvate- ubiquinol 3-phospho- arg alanine glutamate an octanoyl-[acp] a biotinylated fatty acid (R)-methylmalonyl- alanine phosphopentane 1-(5-phospho- butanoate semialdehyde phosphate L-aspartyl- MTRI00966 fumarate ala protein oxidase, R: 3xrn (S)-2-acetolactate L-serine racemase: L-homocysteine [BCCP monomer] CoA tRNA processing pathway I Carbohydrate Degradation racemase: D-ribosyl)-AMP 4-phosphate biosynthesis V alanine phosphotransferase: subunit II: cyoA phosphatase: dihydrodipicolinate N-acetyl- keto- 3-oxoacyl- Methylmalonyl- alr a nucleoside 5'- ketol-acid phosphoserine alr dehydrogenase: MTRI01656 1,2-dihydroxy-MTRI01981 Phosphoribosyl- synthase: dapA gamma- aspartate- phenylpyruvate [acyl-carrier- CoA mutase: a polycistronic [+ 2 isozymes] monophosphate reductoisomerase: phosphatase glycogen degradation I alaDH 5-(methylthio) AMP L-ornithine D-alanine 2-oxoglutarate gln protein] 2,3-dihydroxy- dihydrodipicolinate glutamyl- semialdehyde SerB: MTRI02379 MTRI02588 tRNA precursor galactose degradation pyruvate π cyclohydrolase: ilvC a protein-N pyridoxamine pyruvate pent-1-en-3-one 3-methylvalerate synthetase: phosphate dehydrogenase: synthase 2: [+ 2 isozymes] I (Leloir pathway) MTRI02086 2,3-dihydroxy-3- a biotinylated a glycogen -phospho- pyruvate ubiquinone-8 H O 5'-phosphate reductase: MTRI02523 ser ornithine MTRI02540 2 1-(5-phosphoribosyl)-5- dihydroxy-acid MTRI03001 Glutamate [BCCP dimer] succinyl-CoA succinate methylbutanoate aminotransferase: oat [+ 2 isozymes] β-D-galactose L-histidine dehydratase: argC L-aspartate- phe cysteine biosynthesis I synthase [(5-phosphoribosylamino) dihydroxy-acid (S)-2,3- Glycine ilvD N-acetyl-L- γ acetyl-CoA methylideneamino]imidazole- dihydrodipicolinate semialdehyde hydroxymethyltransferase: L-glutamate - (ferredoxin): acetyl-CoA a tRNA precursor a tRNA precursor Aldose 1- dehydratase: glutamate 5- a 3-oxodecanoyl-[acp] carboxylase, 5-phospho-α-D- (R)-3- 4-carboxamide 2-keto-3- Homoserine MTRI00618 semialdehyde MTRI01349 carboxylase, with a 5' with a 5' epimerase: 4-aminobenzoate O-succinyl-L- D-alanyl-D-alanine ilvD dihydrodipicolinate semialdehyde ser carboxyl an α-limit dextrin ribose 1-diphosphate a tRNA precursor hydroxybutanoyl- phosphoribosylformimino- methyl-valerate dehydrogenase: biotin extension and extension and a MTRI01679 homoserine reductase: dapB acetylornithine and transferase, CoA D-Ala-D-Ala 5-aminoimidazole 2-oxoisovalerate branched-chain MTRI01963 gly carboxylase: a long 3' trailer short 3' extension 3-hydroxyacyl- (S)-2,3,4,5- bicarbonate succinylornithine serine O- glt beta subunit: α-D-galactose dipeptidase: carboxamide ribotide amino acid asparagine accC ribonuclease Amylo- beta- CoA tetrahydrodipicolinate aminotransferase: acetyltransferase: accD MTRI01561 isomerase: MTRI00367 L-homoserine (S)-1-pyrroline- biosynthesis III P protein alpha-16- Protein Degradation ribonuclease dehydrogenase 2-isopropylmalate aminotransferase: Carbamoyl- argD cysE a (3R)-3- ribofuranosylaminobenzene O-succinylhomoserine 2,3,4,5- 5-carboxylate (tRNA-dependent) a carboxylated- component: glucosidase: D: rnd NAD-binding: phosphoribulosylformimino- ilvE_I phosphate [+ 3 isozymes] hydroxydecanoyl-[acp] 5'-phosphate synthase sulfhydrylase: oshs D-alanine synthase: leuA tetrahydropyridine- N-acetyl-L- biotinylated a tRNA rnpA MTRI02144 MTRI02980 AICAR-P synthase L delta-1-pyrroline- α wound-induced seed germination family: MTRI03971 2,6-dicarboxylate N- ornithine asp beta- [BCCP dimer] precursor with a tRNA precursor -D-galactose ile chain ATP- 5-carboxylate O-acetyl-L-serine proteolysis I protein turnover acetoacetyl-CoA (2S)-2- val succinyltransferase: hydrogen sulfide hydroxyacyl- a 5' extension with a short a debranched 1-phosphate binding: acetylornithine dehydrogenase: maltotetraose succinate a nucleoside 5'- a tRNA imidazoleglycerol isopropylmalate dapD (acyl-carrier- TCA cycle TCA cycle 3' extension α-limit dextrin 4-(β-D-ribofuranosyl) L-homocysteine MTRI03444 deacetylase O-succinyl-L- dpcdh Peptide Peptide monophosphate phosphate 3-isopropylmalate cys an L-aspartyl- protein) aminobenzene-5'-phosphate N-succinyl-2-amino- (ArgE): argE homoserine Asn cysteine Leucyl Leucyl synthase, cyclase dehydratase, [+ 3 isozymes] [tRNA ] dehydratase 6-ketopimelate glt synthase A: cysK oxaloacetate aminopeptidase: aminopeptidase: subunit: hisF small subunit: leuD carbamoyl- FabZ: fabZ UDP-D-galactose α-D-glucose succinyl- L-ornithine Cystathionine MTRI00871 MTRI00871 imidazole glycerol 3-isopropylmalate proline phosphate an uncharged α-D-glucose 1-phosphate a [protein] N- adenosine 3',5'- diaminopimelate gamma- maltotriose UDP- Leucyl Leucyl histidinol phosphate dehydratase, biosynthesis I cys a (2E)-dec-2-enoyl-[acp] tRNA 1-phosphate arg gly a prolipoprotein terminal-formyl- bisphosphate desuccinylase: synthase: citrate synthase glucose 4- aminopeptidase: aminopeptidase: L-methionine synthase, glutamine large subunit: leuC ornithine an L-asparaginyl- 3'(2'),5'- histidinol dapE MTRI01910 I: MTRI00933 epimerase: MTRI00678 MTRI00678 amidotransferase [tRNA Asn ] bisphosphate dehydrogenase: glt carbamoyltransferase: otc tryptophan biosynthesis galE β Peptide Peptide subunit: hisH 2-isopropylmaleate N-succinyl-L,L-2,6- -D-glucose Glycine peptide nucleotidase: hisD glutamate α lipoprotein signal diaminopimelate (S)-malate citrate -D-glucose 1-phosphate amidinotransferase: deformylase: cysQ 5-kinase: L-cystathionine α-D-glucose maltose UDP-D-glucose peptidase: lspA aminoimidazole D-erythro- 3-isopropylmalate succinyl- L-citrulline chorismate 6-phosphate MTRI02275 his proB superpathway of a decanoyl-[acp] MTRI00867 carboxamide imidazole-glycerol- dehydratase, L-glutamate- diaminopimelate AMP asparagine biosynthesis fumarate hydratase, ribonucleotide phosphate small subunit: leuD 5-phosphate desuccinylase: cystathionine anthranilate synthase tyrosine biosynthesis I asn aconitate argininosuccinate 3-oxoacyl- class II: fumC_II β-D-glucose- an N-terminal L- Imidazoleglycerol- 3-isopropylmalate gamma- dapE beta-lyase: cysB component I: trpE hydratase 1: aco guanidinoacetate apolipoprotein a signal peptide formate synthase: argG [acyl-carrier- 6-phosphate L-ornithine methionyl-[protein] phosphate dehydratase, glutamyl chorismate asp glycogen β-D-glucose L-arginino- anthranilate protein] superpathway of fatty acid biosynthesis I (E. coli) dehydratase: large subunit: leuC phosphate L,L-diaminopimelate L-homocysteine chorismate mutase: cis-aconitate degradation II succinate synthase 2: fumarate MTRI00370 (2R,3S)-3- reductase: MTRI00132 aconitate anthranilate MTRI02540 argininosuccinate asparagine asparagine acetyl-CoA a glycogen RNase III mRNA 1D-myo- a uridine 38- imidazole acetol- isopropylmalate proA diaminopimelate chorismate mutase: succinate hydratase 1: aco a proteinogenic a 5-L-glutamyl- Rh lyase: argH phosphoribosyltransferase: trpD synthase: synthase [+ 2 isozymes] β-D-glucose- processing inositol (1)- 40 in tRNA phosphate 3-isopropylmalate γ epimerase: DapF MTRI01641 superpathway dehydrogenase, amino acid [peptide] L-glutamate - MTRI00562 (glutamine- 6-phosphate substrate monophosphate pseudouridine cytochrome dehydrogenase: prephenate of glutamate acetyl-CoA cytochrome b556 inositol histidinol-phosphate semialdehyde N-(5'-phosphoribosyl)-anthranilate [+ 2 isozymes] hydrolyzing) a 3-oxododecanoyl-[acp] an α-limit dextrin synthase, P450: leuB arg biosynthesis subunit: MTRI03870 aminotransferase: meso-diaminopimelate met carboxylase, monophosphatase: MTRI02769 Prephenate : MTRI02127 Carboxylate Degradation gamma- RluA family: hisC (2S)-2-isopropyl- Phosphoribosylanthranilate biotin carboxyl succinate D-threo-isocitrate ribonuclease MTRI02559 serine biosynthesis dehydrogenase: glt [+ 3 isozymes] isocitrate glutamyltransferase: MTRI00810 [+ 2 isozymes] 3-oxosuccinate diaminopimelate isomerase: MTRI02653 an acetyl-[acp] carrier III: MTRI03346 inositol L-histidinol- MTRI00134 Glutamate--ammonia asn dehydrogenase, MTRI01393 [+ 3 isozymes] an alcohol decarboxylase: lysA ligase: MTRI01977 protein: BCCP a α-limit glutaryl-CoA monophosphatase: a pseudouridine 38- phosphate (S)-1-pyrroline- 3-phospho- 1-(o-carboxyphenylamino)-1'- NADP- superpathway of methylmalonyl 4-hydroxyphenylpyruvate a (3R)-3- degradation MTRI01633 5-carboxylate D-glycerate deoxyribulose-5'-phosphate glutamine synthetase, asn acetyl-CoA dependent: idh1 dextrin with α γ RNase III 40 in tRNA histidinol- tyrosine D-3- hydroxydodecanoyl-[acp] D-glucarate and D- pathway an -( -L- a single- myo-inositol pyrroline-5- lys Indole-3-glycerol- type I: GlnA carboxylase, short branches Peptide processing phosphate 4-methyl-2- biosynthesis IV phosphoglycerate threonine biosynthesis glutaryl-CoA galactarate degradation glutamyl)-L- stranded RNA carboxylate phosphate synthase: gln beta- biotin Amylo- product mRNA phosphatase: oxopentanoate dehydrogenase: from homoserine propanoyl-CoA amino acid carboxylase: accC succinyl-CoA alpha-16- D-galactarate D-glucarate reductase: pgdh MTRI02075 hydroxyacyl- 2-oxoglutarate MTRI01673 phe 3-phospho- L-glutamate:NADP+ glucosidase: proC (1S,2R)-1-C-(indol-3- (acyl-carrier- phenylalanine- hydroxypyruvate tyr oxidoreductase L-homoserine MTRI02144 glutaconyl-CoA histidinol protein) (S)-methylmalonyl- H O a phenol sulfate 4-hydroxylase: yl)glycerol 3-phosphate homoserine malonyl-CoA dihydrolipoate ribose-1-arsenate diphosphate 2 RNA (R)-lactate pro alanine phosphoserine (transaminating) dehydratase a debranched CoA MTRI00074 kinase: 3-oxoacyl-(acyl- D-isomer specific sulfatase: histidinol leu biosynthesis III aminotransferase: tryptophan synthase, : gltB gltD FabZ: fabZ malonyl CoA-acyl 2-oxoglutarate α-limit dextrin methylmalonyl- thrB_alt carrier-protein) 5-dehydro-4- 2-hydroxyacid MTRI04241 dehydrogenase: tyr serC_2 alpha subunit: trpA Glutamate synthase O-phospho- carrier protein dehydrogenase, CoA epimerase: a (2E)-dodec- synthase III: fabH deoxy-D-glucarate arsenate hisD E1 subunit: akgdhE1 MTRI00828 Inorganic ribonuclease dehydrogenase sulfatase: cys 3-phospho- (NADPH): MTRI00803 L-homoserine transacylase: fabD crotonyl-CoA reductase: arsC indole ser 2-enoyl-[acp] [+ 2 isozymes] diphosphatase: PH: RNasePH NAD-binding: MTRI02433 threonine an acetoacetyl-[acp] malonyl CoA-acyl α-D-glucose (R)-methylmalonyl- histidinal L-serine glt arsenate MTRI01022 MTRI03590 a phenol synthase: carrier protein 1-phosphate CoA reductase: arsC histidinol phosphoserine tartronate pyruvate tryptophan synthase, thrC transacylase: fabD TCA cycle variation I Methylmalonyl- a nucleoside dehydrogenase: ala phosphatase RNA (S)-3- semialdehyde + SerB: MTRI02379 beta subunit: trpB CoA mutase: phosphate H diphosphate hisD thr a dodecanoyl-[acp] a malonyl-[acp] hydroxybutanoyl- 2-hydroxy-3- MTRI02588 arsenite (R)-lipoate D-ribose (S)-malate α-D-glucose ser Beta-ketoacyl- CoA oxopropionate trp a 3-oxoacyl-[acp] 6-phosphate [+ 2 isozymes] his acyl-carrier- 3-hydroxyacyl- reductase: protein synthase 3-oxoacyl- CoA MTRI02034 succinyl-CoA 34 α-D-glucose guanine in tRNA an oligopeptide an organic [acyl-carrier- III: MTRI04299 dehydrogenase queuine 1-phosphate UTP D-glycerate Storage Compound Biosynthesis fumarate hydratase, D-glycerate with GUN anticodon hydroperoxide protein] fumarate oxaloacetate NAD-binding: alkyl 2-hydroxy-3- laurate class II: fumC_II synthase 2: MTRI02980 hydroperoxide oxopropionate 3-oxoacyl-(acyl- UTP-glucose- Peptidyl- polyhydroxybutyrate biosynthesis MTRI02540 citrate synthase queuine tRNA- reductase, reductase: carrier-protein) conversion of succinate to propionate 1-phosphate dipeptidase [+ 2 isozymes] I: MTRI00933 acetoacetyl-CoA ribosyltransferase: tgt F subunit: MTRI02034 synthase III: fabH uridylyltransferase: Dcp: MTRI01855 acetyl-CoA 2-phospho- MTRI02138 tartronate acetyl-CoA galU 3-oxoacyl-(acyl- succinate citrate D-glycerate succinyl-CoA semialdehyde purine nucleotides de novo biosynthesis II Nucleoside and Nucleotide Biosynthesis a 3-oxotetradecanoyl- acetyltransferase: Methylmalonyl- a tRNA containing an alcohol pyrimidine deoxyribonucleotides de novo biosynthesis II superpathway of 5-aminoimidazole acetyl-CoA carrier-protein) glyoxylate guanosine nucleotides adenosine nucleotides [acp] aconitate MTRI03447 CoA mutase: GUN anticodon with a dipeptide an oligopeptide ribonucleotide biosynthesis acetyltransferase: a 2,3,4-saturatedsynthase III: fabH a (3R)-3-hydroxyacyl- guanine de novo biosynthesis de novo biosynthesis hydratase 1: aco MTRI02588 quenosine at position 34 UDP-D-glucose 5-phospho-α-D-ribose 1-diphosphate CDP MTRI03447 fatty acyl-[acp] [acyl-carrier protein] succinic semialdehyde [+ 2 isozymes] 5-phospho-α-D- beta-hydroxyacyl- [+ 2 isozymes] [+ 2 isozymes] dehydrogenase: ssadh cis-aconitate IMP ribose 1-diphosphate (acyl-carrier- succinate semialdehyde aconitate acetyl-CoA amidophosphoribosyltransferase: purF IMP amidophosphoribosyltransferase: purF acetoacetyl-CoA a (3R)-3- protein) hydratase 1: aco all-trans- dehydratase (R)-methylmalonyl- an L-arginyl- dihydrolipoamide octanal dCDP 5-phospho-β- hydroxytetradecanoyl- propanoyl-CoA a protein hexaprenyl inosine-5'- CoA [tRNA Arg ] 4-hydroxybenzoate GTP 5-phospho-β-D-ribosyl-amine adenylosuccinate acetoacetyl- [acp] FabZ: fabZ diphosphate dihydrolipoamide Aldehyde monophosphate D-ribosyl-amine a (3R)-3- synthetase: purA Nucleoside- CTP CoA beta- Degradation/Utilization/Assimilation - Other dehydrogenase: dehydrogenase dehydrogenase: hydroxydecanoyl-[acp] 2-oxoglutarate D-threo-isocitrate diguanylate diphosphate reductase: hydroxyacyl- 4-hydroxybenzoate MTRI00519 cyclase: (NAD(+)): impdh UDP beta-hydroxyacyl- Arginyltransferase: adenylo-succinate kinase: MTRI01595 MTRI02528 (acyl-carrier- alkylnitronates polyprenyl dihydrolipoamide GGDEF MTRI03744 (R)-3- protein) (acyl-carrier- acrylonitrile degradation MTRI02593 XMP 5-phospho-ribosyl- isocitrate degradation transferase: ubiA dehydrogenase: [+ 11 isozymes] octanoate 5-phospho-ribosyl-glycineamide adenylosuccinate hydroxybutanoyl- poly-[(R)-3- dehydratase a trans-2-enoyl- protein) cyclic di-3',5'- dCTP glycineamide dehydrogenase, MTRI03609 lyase: purB CoA hydroxybutanoate] FabZ: fabZ dehydratase guanylate dUDP phosphoribosylglycinamide [acyl-carrier protein] ethylnitronate phosphoribosylglycinamide GMP GMP phosphoribosylglycinamide FabZ: fabZ NADP-dependent: idh1 acrylonitrile a [protein]- 3-hexaprenyl-4- lipoamide 2-deoxycytidine formyltransferase: PurN 2-nitropropane a tRNA Arg formyltransferase: PurN synthase, synthase, formyltransferase: PurN a (2E)-tetradec- L-arginine hydroxybenzoate Nucleoside- 5-triphosphate UTP dioxygenase large subunit: large subunit: AMP 5'-phosphoribosyl-N 2-enoyl-[acp] a (2E)-dec-2-enoyl-[acp] diphosphate deaminase: NPD: MTRI04212 Aromatic Compound Degradation 5'-phosphoribosyl-N-formylglycineamide guaA_Cterm guaA_Cterm -formylglycineamide kinase: MTRI01595 MTRI02050 poly-[(R)-3- Pentose Phosphate Pathways nitrite UDP-α-N-acetyl-D-glucosamine N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-L-lysyl- adenylate phosphoribosylformylglycinamidine hydroxybutanoate] a kanamycin a reduced c- phosphoribosylformylglycinamidine 4-hydroxyphenylacetate D-alanyl-D-alanine-diphosphoundecaprenol RNA squalene GMP kinase: adk synthase II: fgams nitrite reductase acrylate acrylamide 3-chlorocatechol salicylate type cytochrome synthase II: fgams dUTP pentose phosphate pathway (non-oxidative branch) degradation aminoglycoside squalene- [+ 2 isozymes] [NAD(P)H], large degradation II (ortho) degradation I Cytochrome- [+ 2 isozymes] a myristoyl-[acp] Undecaprenyldiphospho- phosphotransferase: hopene guanylate a (3Z)-dec-3-enoyl-[acp] subunit: MTRI02239 Amidase: c peroxidase: 5-phosphoribosyl-N- D-ribulose- FAD muramoylpentapeptide beta-N- polyribonucleotide MTRI03905 ADP MTRI01748 salicylate MTRI01105 cyclase: 5-phosphoribosyl-N-formylglycineamidine kinase: formylglycineamidine 3-oxoacyl- 5-phosphate nitrite reductase 3-chlorocatechol acetylglucosaminyltransferase: nucleotidyltransferase: Salicylate 1- aminoglycoside MTRI02657 MTRI02537 dUMP [acyl-carrier- 3-oxoacyl-[acyl- [NAD(P)H], small MTRI03785 MTRI01906 [+ 8 isozymes] phosphoribosylformylglycinamidine acrylate monooxygenase: phosphotransferase: an oxidized c- hop-22(29)-ene phosphoribosylformylglycinamidine carrier-protein] ribose 5- ribulose- subunit: MTRI02240 thymidylate protein] MTRI03052 cyclo-ligase: purM H+transporting cyclo-ligase: purM synthase 2: 2-chloro- MTRI00044 type cytochrome GDP synthase, flavin- pyrimidine ribonucleotides de novo biosynthesis synthase 2: phosphate phosphate 3- N-acetylmuramoyl-L-alanyl-D- a kanamycin two-sector 5-amino-1-(5-phospho- MTRI02540 ammonium 4-hydroxyphenylacetate FADH cis,cis-muconate catechol UDP a nucleoside RNA dependent: MTRI02540 isomerase: epimerase: 2 glutamyl-L-lysyl-D-alanyl-D-alanine- 3'-phosphate 5-amino-1-(5-phospho-D-ribosyl)imidazole ATPase D-ribosyl)imidazole diphosphate a (5Z)-3-oxododec- rpiA rpe diphosphoundecaprenyl-N-acetylglucosamine gamma subunit: MTRI02401 bicarbonate [+ 2 isozymes] phosphoribosylaminoimidazole Nucleoside- dADP 5-enoyl-[acp] MTRI01751 dTMP purine and pyrimidine metabolism a 3-oxohexadecanoyl- carboxylase, ATPase subunit: purK diphosphate Carbamoyl- D-ribose 5- D-xylulose- (+)-5- [+ 12 isozymes] [acp] phosphate 5-phosphate (2E,6E)-farnesyl (S)-1-pyrroline- phosphoribosylaminoimidazole kinase: thymidylate phosphate chloromuconolactone glutathione canavaninosuccinate preQ thymine a phytochelatin protoheme IX 5-carboxylate 1 MTRI01595 uridine 3,4-dihydroxyphenylacetate diphosphate carboxylase, catalytic subunit: purE dGDP Nucleoside- kinase: MTRI01603 synthase L delta-1-pyrroline- 7-cyano-7- adenosine guanosine transketolase: tkl 5-amino-1-(5-phospho-D- diphosphate dTDP chain ATP- a (3R,5Z)-3-hydroxydodec- 5-carboxylate deazaguanine ATP ribosyl)imidazole-4-carboxylate kinase: binding: a (3R)-3- 5-enoyl-[acp] Glutathione gamma- protoheme IX argininosuccinate dehydrogenase: reductase: Nucleoside- D-sedoheptulose D-glyceraldehyde- GTP MTRI01595 MTRI03444 thymidine uracil hydroxyhexadecanoyl- cis-dienelactone glutamylcysteinyltransferase: farnesyltransferase: lyase: argH dpcdh MTRI02823 phosphoribosylaminoimidazole- Nucleoside- diphosphate beta-hydroxyacyl- 7-phosphate 3-phosphate Alcohol Degradation 2-hydroxy-5- succinocarboxamide diphosphate [+ 3 isozymes] [acp] (acyl-carrier- MTRI01392 cyoE_ctaB preQ kinase: MTRI01595 carboxymethylmuconate dienelactone glt 0 beta- synthase: purC kinase: carbamoyl- protein) semialdehyde dTTP glycerol and hydrolase: MTRI01595 hydroxyacyl- dehydratase L-canavanine fumarate 5'-phosphoribosyl-4-(N- phosphate adenine guanine dTMP MTRI03626 gly a phytochelatin xanthine and UMP (acyl-carrier- FabZ: fabZ glycerophosphodiester degradation heme o succinocarboxamide)-5-aminoimidazole D-erythrose- D-fructose- dATP xanthosine salvage aspartate protein) 2-maleylacetate adenylosuccinate Xanthine thymidylate a (2E,5Z)-dodeca- 4-phosphate 6-phosphate a glycerophosphodiester carbamoyltransferase: atc adenine dehydratase 5-carboxymethyl-2- lyase: purB phosphoribosyltransferase: kinase: 3,5-dienoyl-[acp] CTP phosphoribosyltransferase: apt FabZ: fabZ glycerol hydroxymuconate a 2,3,4-saturated xanthosine N-carbamoyl- MTRI01093 MTRI01603 transketolase: tkl pentose phosphate pathway (partial) an L-aspartyl- L(or D)-O- dUMP 1,2-diacyl-sn- asp trp aminoimidazole carboxamide ribonucleotide L-aspartate uridine UDP a (2E)-hexadec- glycerophosphoryl O-ureidohomoserine Asn CTP [tRNA ] phosphoserine 2-enoyl-[acp] D-glyceraldehyde- D-ribulose- diester glycerol glycerol 3-phosphate AMP GMP dTDP 3-oxoadipate glutamyl-tRNA(Gln) phosphoserine L-amino-acid dGTP Nucleoside- 3-phosphate 5-phosphate phosphodiesterase: kinase: xanthine 4-chlorocatechol amidotransferase, phosphatase oxidase: CMP diphosphate a (5Z)-dodec-5-enoyl-[acp] MTRI01047 glyK 5-carboxy-2-oxohept-3-enedioate phosphatidate CTP guanylate ribulose- degradation argininosuccinate B subunit: gatB SerB: MTRI02379 MTRI02110 kinase: adenylate cytidine cytidylyltransferase: Xanthine synthase: cytidylate kinase: phosphate 3- synthase: argG [+ 2 isozymes] 2-imino-3-(indol- phosphoribosyl-formamido-carboxamide MTRI01595 (S)-dihydroorotate kinase: adk MTRI01772 an L-asparaginyl- phosphoribosyltransferase: PyrG kinase: cmk MTRI02537 epimerase: sn-glycerol- 4-chlorocatechol serine 3-yl)propanoate a palmitoyl-[acp] [tRNA Asn ] MTRI01093 rpe 3-phosphate aldoxime 5-phospho- degradation ADP GDP CMP D-xylulose- D-erythrose- 2-hydroxyhepta-2,4-dienedioate a CDP-2,3,4-saturated- canavaninosuccinate CDP α-D-ribose 1- 3-chloro- XMP 5-phosphate 4-phosphate E-pyridine- diacylglycerol salvage pathways of pyrimidine ribonucleotides orotate diphosphate cis,cis-muconate 3-aldoxime IMP UTP dihydroxyacetone palmitate transketolase: tkl transketolase: tkl cytidine Nucleoside- orotate CDP phosphate dimethylallyl an organic a [protein]- a [protein]- an oxidized a protein diphosphate orotidine 5'- phosphoribosyltransferase: 4-hydroxy-2-ketopimelate 3-cyanopyridine diphosphate a tRNA hydroperoxide L-cysteine L-glutamate D-glyceraldehyde- Protein-glutamate O- cytochrome c kinase: phosphate pyrE cis-dienelactone 3 adenylosuccinate inosine-5'-monophosphate cytosine 3-phosphate methyltransferase: Cytochrome-c3 MTRI01595 decarboxylase: Fatty Acid and Endopeptidase synthetase: purA dehydrogenase: impdh peroxiredoxin: MTRI00187 hydrogenase: uridine CMP pyrF orotidine-5'- Lipid Degradation dienelactone tRNA delta(2)- Clp: MTRI01952 UDP UMP isopentenylpyrophosphate MTRI02137 MTRI02284 phosphate hydrolase: a [protein]-L-[+ 5 isozymes] fatty acid β-oxidation I transferase: miaA [+ 3 isozymes] a reduced adenylo-succinate succinate semialdehyde nicotinamide MTRI03626 5 Peptide XMP glutamate-O Carbohydrate Biosynthesis glycolysis I Glycolysis cytochrome c gluconeogenesis I a (3Z)-alk-3- -methyl-ester 3 adenylosuccinate CDP trehalose biosynthesis I succinic 2-maleylacetate a tRNA containing N 6 - an intra- lyase: purB uracil UMP O-antigen building blocks biosynthesis (E. coli) β-D-glucose- enoyl-CoA semialdehyde an alcohol GMP synthase, large Nucleoside- dimethylallyladenosine protein disulfide (S)-malate α-D-glucose 6-phosphate dehydrogenase: subunit: guaA_Cterm diphosphate α UDP-D-glucose UDP-D-galactose -D-glucose D-fructose- 6-phosphate ssadh nicotinate AMP kinase: 1-phosphate 6-phosphate Glucose-6- an N-acyl- MTRI01595 glucose-1-phosphate Glutamine- GDP-mannose phosphate a (2E)-2- succinate 3-oxoadipate a [protein] C-terminal di-trans,octacis a proteinogenic GMP Alpha,alpha- a 2-oxo acid L-ornithine UDP-D-galacto- thymidylyltransferase: -fructose-6- biosynthesis isomerase: enoyl-CoA neuraminate CTP S-farnesyl-L-cysteine -undecaprenol amino acid CTP 1,4-furanose rmlA phosphate trehalose- MTRI04037 Isoprenylcysteine pyruvate dTDP-α-D-glucose phosphate β-D-glucose- carboxyl undecaprenol L-amino-acid oxaloacetate transaminase CMP-KDO biosynthesis I acylneuraminate synthase 6-phosphate D-fructose- methyltransferase: kinase: undecK oxidase: dTDP- (isomerizing) Glucose-6- ornithine cytidylyltransferase: (UDP-forming) 6-phosphate a 2,3,4- MTRI00890 ditrans,octacis MTRI02110 phosphoenolpyruvate glucose 4,6- : MTRI02636 D-ribulose- phosphate aminotransferase: oat MTRI04076 a [protein] C-terminal D-glucosamine : MTRI03437 saturated (3R)-3- -undecaprenyl synthase: peps dehydratase: 5-phosphate isomerase: S-farnesyl-L- a 2-oxo acid 6-phosphate fructose-1,6- a 2,3,4- hydroxyacyl-CoA phosphate MTRI00641 Alpha,alpha- MTRI04037 a 2,3,4-saturated saturated (3S)-3- cysteine methyl ester D-fructose- bisphosphatase, a proteinogenic L-glutamate γ- a CMP-N-acyl- phosphoenol phosphoglucosamine trehalose- D-arabinose fatty acyl CoA dTDP-4-dehydro- 6-phosphate class II: glpX hydroxyacyl-CoA3-hydroxyacyl- neuraminate pyruvate mutase: glmM 5-phosphate amino acid semialdehyde 6-deoxy-α-D- phosphate CoA D-glucosamine fructose-1,6- enolase: glucopyranose synthase 2-dehydro-3- dihydroxyacetone dehydrogenase dTDP-4- 1-phosphate (UDP-forming) deoxyphosphooctonate phosphate bisphosphate eno NAD-binding: α-D-glucose dehydrorhamnose : MTRI01209 aldolase: kdo D-mannose carbamoyl- fumarate long chain 2-phospho- coenzyme A MTRI02980 L-canaline asp L-homocysteine polyphosphate 6-phosphate 3,5-epimerase: rmlC 3-deoxy-D-manno 6-phosphate phosphate Glucose-6- D-glycerate dTDP-4-dehydro- triosephosphate a 2,3,4-saturated a 2,3,4-saturated N-acetyl-α-D- trehalose 6- -octulosonate Phosphomannomutase: homocysteine S- Polyphosphate phosphate 6-deoxy- isomerase: tim fatty acyl CoA 3-oxoacyl-CoA glucosamine phosphate 8-phosphate MTRI02762 L-aspartate methyltransferase: kinase: isomerase: L-mannose a 2,3,4-saturated MTRI01310 1-phosphate trehalose- α ornithine oxidase: MTRI03561 MTRI04037 dTDP-4- -D-mannose fatty acid phosphatase: D-glyceraldehyde- carbamoyltransferase: otc nadB long chain D-fructose- 3-phospho- dehydrorhamnose UDP-N- 1-phosphate met MTRI03439 3-deoxy-D-manno 3-phosphate polyphosphate 6-phosphate D-glycerate reductase: rmlD acetylglucosamine glycocholate metabolism (bacteria) pyrophosphorylase: -octulosonate peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis Phosphoglycerate dTDP-α-L- trehalose 2-keto-L-gulonate α-iminosuccinate succinate peptidoglycan biosynthesis III (mycobacteria) glmU 3-deoxy-D-manno- acetyl-CoA O-ureidohomoserine kinase: MTRI03654 rhamnose α biosynthesis α octulosonate GDP- -D- glycocholate UDP-α-N-acetyl-D-glucosamine UDP-α-N-acetyl- UDP- -N-acetyl- 1,3-bisphospho- cytidylyltransferase: mannose D-sorbitol D-glucosamine D-glucosamine Choloylglycine D-glycerate kdsB 1,3-bisphospho- hydrolase: (S)-methylmalonyl-CoA NADPH propanoyl-CoA H + a peptidoglycan a relaxed DNA a phenolic donor GDP-D-rhamnose CMP-3-deoxy- an acyl phosphate UDP-N-acetylglucosamine- CMP-KDO biosynthesis GDP-L-colitose D-glycerate MTRI02733 biosynthesis D-manno- L-sorbopyranose acylphosphatase: DNA gyrase, enolpyruvate II (from D-arabinose biosynthesis Choloylglycine Catalase: UDP-N-acetylglucosamine- octulosonate MTRI04246 B subunit: gyrB dihydroxyacetone D-glyceraldehyde- 5-phosphate) CMP-N- hydrolase: 6-deoxyerythronolide-B Lysozyme: MTRI00683 UDP-N- enolpyruvate α GDP-α-D-mannose Phosphoglycerate DNA gyrase, phosphate 3-phosphate D-arabinose GDP- -D-mannose acetylneuraminate MTRI00429 acylphosphatase: acetylenolpyruvoylglucosamine GDP- kinase: MTRI03654 MTRI02734 synthase: MTRI04132 A subunit: gyrA glt UDP-N- 5-phosphate GDP- biosynthesis II (bacteria) MTRI00960 a phenoxyl radical reductase: murB acetylenolpyruvoylglucosamine 2-dehydro-3- UDP-α-N-acetyl- mannose 4,6- [+ 4 isozymes] a negatively ala glt mannose 4,6- L-sorbosone cholate a carboxylate of a phenolic donor reductase: murB deoxyphosphooctonate D-glucosamine dehydratase: supercoiled DNA UDP-N-acetylmuramate dehydratase: UDP-N- 3-phospho- N-acetyl-D- a peptidoglycan glutamate racemase: ala gmd PRPP biosynthesis I glutamate 3-deoxy-D-mannoaldolase: kdo gmd GDP-4-dehydro-6- D-glycerate glucosamine with cleaved N- MTRI03794 UDP-N-acetylmuramate fructose-1,6- GDP-4-dehydro-6- acetylglucosamine 6-deoxyerythronolide b racemase: -octulosonate deoxy-D-mannose acetyl-glucosamine bisphosphate deoxy-D-mannose β 2-epimerase: wecB D-ribose 5- MTRI03794 8-phosphate N-acetyl- -D- L-sorbosone D-glutamate fructose-1,6- phosphate α α 3α,7α- mannosamine ribose-phosphate 2,6-lactone 3 ,12 - UDP-N-acetylmuramyl-L-Ala 3-dehydrocholate a guanine 46 a negatively a monocarboxylic D-glutamate bisphosphatase, pyrophosphokinase: dihydroxy-7- dihydroxy-12- a phosphatidylcholine a sterol a formylmethanofuran UDP-N-acetylmuramyl-L-Ala L-sorbosone β β in tRNA supercoiled DNA acid amide class II: glpX GDP-4-dehydro- GDP-D-rhamnose rpppk oxo-5 -cholanate oxo-5 -cholanate 3-deoxy-D-manno dehydrogenase: 2-phospho- formylmethanofuran tRNA (guanine-N(7)- DNA D-fructose- 3,6-dideoxymannose ribose-phosphate homolactic fermentation oleate β-oxidation Amidase: -octulosonate N-acetylneuraminate MTRI00015 D-glycerate dehydrogenase )-methyltransferase: topoisomerase 6-phosphate pyrophosphokinase: Lecithin:cholesterol MTRI01748 meso-diaminopimelate UDP-N-acetylmuramoyl- 3-deoxy-D-manno- subunit C: MTRI01109 MTRI00912 I: topA rpppk 2-keto-L-gulonate 2-trans,5-cis- acyltransferase: 7 Glucose-6- octulosonate 5-phospho- β-D-glucose isocholate formylmethanofuran an N - [+ 3 isozymes] L-alanyl-D-glutamate meso-diaminopimelate UDP-N-acetylmuramoyl- enolase: 7-epicholate 12-epicholate MTRI00280 phosphate cytidylyltransferase: α-D-ribose 1- tetradecadienoyl-CoA methylguanine 46 a monocarboxylate L-alanyl-D-glutamate GDP-L-colitose eno dehydrogenase a relaxed DNA UDP-N- D-alanine isomerase: kdsB CMP-N- diphosphate subunit A: MTRI01111 in tRNA acetylmuramyl- UDP-N- MTRI04037 CMP-3-deoxy- acetylneuraminate a 1-acyl-sn-glycero- a steryl-ester a methanofuran tripeptide acetylmuramyl- D-alanine β-D-glucose- D-manno- phosphoenol β-D-glucose- 3-phosphocholine synthetase: murE tripeptide 6-phosphate octulosonate pyruvate 6-phosphate 3,5-tetradecadienoyl- 3-hydroxy-5-cis- synthetase: murE CoA tetradecenoyl-CoA Aromatic Compound Biosynthesis pyruvate Glucose-6- UDP-N-acetylmuramoyl-L-alanyl-D- D-alanyl-D-alanine Secondary Metabolite Biosynthesis acyl-CoA phytanoyl-CoA S-lactoyl- kinase: phosphate 2-oxoglutarate a tRNA an aldehyde 2-oxoglutarate glutamyl-meso-2,6-diaminopimelate UDP-N-acetylmuramoyl- thioesterase: glutathione pvtK isomerase: Aldehyde L-alanyl-D-glutamyl-meso enterobacterial common antigen biosynthesis chorismate biosynthesis I phosphoenolpyruvate MTRI00908 tRNA (guanine-N1)- homocitrate D-alanyl-D-alanine 4-hydroxybenzoate methylerythritol phosphate pathway MTRI04037 dehydrogenase -2,6-diaminopimelate aerobactin mevalonate pathway I synthase: peps Pyruvate Inorganic Nutrient Metabolism Phytanoyl-CoA methyltransferase: synthase: biosynthesis II D-fructose- hydroxyacylglutathione (NAD(+)): biosynthesis kinase: 3,5-tetradecadienoate dioxygenase: trmD MTRI00170 α D-erythrose-4-phosphate 6-phosphate 1 UDP-N-acetylmuramoyl-L- -D-glucose 1-phosphate (bacteria and fungi) D-glyceraldehyde-3-phosphate pyruvate MTRI02411 hydrolase: MTRI01914 an N - MTRI03744 ditrans,octacis- phospho-2-dehydro- acetyl-CoA superpathway of sulfate assimilation MTRI00563 (R)-homocitrate alanyl-D-glutamyl-meso-2,6- chorismate sulfate reduction methylguanine a carboxylate undecaprenyl phosphate 3-deoxyheptonate acetyl-CoA fructose-1,6- and cysteine biosynthesis diaminopimelyl-D-alanyl-D-alanine UDP-α-N-acetyl- glucose-1-phosphate lys II (assimilatory) in tRNA UDP-N-acetylmuramoyl- aldolase: dahps acetyltransferase: pyruvate bisphosphatase, ditrans,octacis- D-glucosamine thymidylyltransferase: deoxyxylulose-5- L-lysine 6- 3-phospho- 2-hydroxyphytanoyl- L-alanyl-D-glutamyl-meso UDP-α-N-acetyl- MTRI03447 class II: glpX succinate (R)-lactate glutathione phospho-N- rmlA phospho-2-dehydro- phosphate synthase: dxs monooxygenase dihydroxyacetone D-glycerate -2,6-diaminopimelyl- undecaprenyl phosphate UDP-N- fructose-1,6- sulfate CoA D-glucosamine 4-hydroxybenzoate (NADPH): [+ 2 isozymes] acetylmuramoyl- D-alanyl-D-alanine acetylglucosamine dTDP-α-D-glucose 3-deoxyheptonate phosphate D-3- sulfate MTRI00232 acetoacetyl-CoA bisphosphate pentapeptide- phospho-N- undecaprenyl-phosphate alpha 2-epimerase: wecB aldolase: aroFGH 1-deoxy-D-xylulose 5-phosphate sulfate phosphoglycerate adenylyltransferase, dTDP-glucose 3-deoxy-D-arabino- triosephosphate a DNA containing an a long-chain (3R)- transferase: mraY acetylmuramoyl- N-acetylglucosaminyltransferase: L-lysine 6- Hydroxymethylglutaryl- glycolysis III dehydrogenase: large subunit: apsK a tRNA a cytosine in DNA ethanol UDP-N-acetyl-D-mannosamine 4,6-dehydratase: heptulosonate-7-phosphate 1-deoxy-D-xylulose isomerase: tim sulfate apurinic/apyrimidinic site 3-hydroxyacyl-CoA pentapeptide- MTRI01150 monooxygenase CoA synthase: pgdh [+ 3 isozymes] N-acetylmuramoyl-L-alanyl- MTRI00641 5-phosphate adenosine 5'- tRNA (5- DNA-cytosine acetoacetyl- transferase: mraY 3-dehydroquinate (NADPH): adenylyltransferase, MTRI04139 β-D-glucose D-glyceraldehyde- 3-phospho- phosphosulfate methylaminomethyl- methyltransferase: CoA Catalase: D-glutamyl-meso-2,6- N-acetylmuramoyl- N-acetyl-α-D-glucosaminyl- dTDP-4-dehydro-6- synthase: aroB reductoisomerase: Dxr MTRI04354 large subunit: apsK N 6 -Hydroxy- (S)-3-hydroxy-3- hydroxypyruvate endonuclease 2-thiouridylate)- dcm reductase: MTRI00683 diaminopimelyl-D-alanyl-D- pentapeptide- diphospho-ditrans,octacis UDP-N-acetyl-β-D- deoxy-α-D-glucopyranose 3-phosphate [+ 3 isozymes] 2-C-methyl-D-erythritol-4-phosphate L-lysine methylglutaryl-CoA phosphoserine III: nth methyltransferase: [+ 2 isozymes] MTRI02528 alanine-diphosphoundecaprenol diphospho-decaprenol -undecaprenol mannosaminouronate 3-dehydroquinate adenosine 5'- aminotransferase: trmU a 5-methylcytosine a long-chain 3- acetaldehyde phosphosulfate in DNA oxoacyl-CoA 3-dehydroquinate 4-diphosphocytidyl- β-D-glucose- serC_2 sulfite a 5-methylaminomethyl- a 3'-terminal 34 dehydratase, 2C-methyl-D-erythritol 6-phosphate 1,3-bisphospho- a 5'-phosphopolynucleotide 2-thiouridine in tRNA N-acetylmuramoyl-L-alanyl- N-acetylglucosamine--N- dTDP-D-fucosamine myo-inositol D-glycerate 3-phospho- unsaturated sugar N-acetyl-β-D- type II: aroQ synthase: MTRI04237 N 6 -acetyl-N 6 - (R)-mevalonate Glucose-6- D-glutamyl-meso-2,6- acetylmuramyl-(pentapeptide) biosynthesis L-serine mannosaminouronyl- 4-(cytidine 5'-diphospho) hydroxy-L-lysine phosphate Phosphoglycerate phosphoadenosine- diaminopimelyl-D-alanyl-D- pyrophosphoryl-decaprenol 3-dehydroshikimate phosphoserine (1->4)-N-acetyl-α-D- -2-C-methyl-D-erythritol D-glucose 6- isomerase: kinase: MTRI03654 5'-phosphosulfate a ring-opened 7- 31-O- alanine-diphosphoundecaprenyl- an L-methionyl- an aliphatic amine Peptidoglycan 4-(cytidine 5'-diphospho) phosphate MTRI04037 phosphatase hydrogen sulfide nicotinamide glucosaminyl-diphospho- dTDP-4-acetamido-4,6- shikimate 5- 3-phospho- Phosphoadenylyl- methylguanine in DNA [initiator tRNA Met ] desmethylFK-506 N-acetylglucosamine glycosyltransferase: SerB: MTRI02379 methyltransferase ditrans,octacis-undecaprenol dideoxy-D-galactose dehydrogenase: aroE -2-C-methyl-D-erythritol mevalonate- D-glycerate sulfate reductase amine oxidase: Peptidoglycan MTRI03791 1D-myo- D-fructose-6-phosphate FkbM family: Amidase: kinase: MTRI02276 5-phosphate (thioredoxin) methionyl-tRNA MTRI00067 glycosyltransferase: a peptidoglycan aerobactin ser MTRI03529 MTRI01748 shikimate 2-phospho-4-(cytidine 5'- inositol (3)- : MTRI01792 formamidopyrimidine- formyltransferase: fmt [+ 2 isozymes] MTRI03791 dimer (mycobacteria) monophosphate DNA glycosylase: fpg diphospho)-2-C-methyl-D-erythritol serine O- an N-formyl- [+ 4 isozymes] a peptidoglycan dimer (meso an aldehyde nicotinate undecaprenyl N-acetyl- 2C-methyl-D-erythritol inositol 2-phospho- sulfite L-methionyl- FK-506 -diaminopimelate containing) acetyltransferase: monophosphatase: fructose-1,6- met glucosaminyl-N-acetyl- 2,4-cyclodiphosphate D-glycerate cysE [initiator tRNA ] mevalonate- bisphosphate 2,6-diamino-4-hydroxy- mannosaminuronate-4- synthase: MTRI01531 MTRI02559 [DNA] a peptidoglycan with L,D a peptidoglycan with D,D diphosphate enolase: [+ 3 isozymes] 5-formamidopyrimidine acetamido-4,6-dideoxy-D- shikimate-3-phosphate inositol cross-links (mycobacteria) cross-links (mycobacteria) 2-C-methyl-D-erythritol- eno a peptidoglycan with galactose pyrophosphate monophosphatase: 2,4-cyclodiphosphate hydrogen sulfide O-acetyl-L-serine D,D cross-links (meso- 3-phosphoshikimate 1- MTRI01633 phosphoenol an [apo BCAA dehydrogenase ammonium UMP carboxyvinyltransferase: 1-hydroxy-2-methyl-2-(E) pyruvate E2 protein] N 6 -S-[2- a nucleobase lesion in DNA 2-phosphoglycolate an oligopeptide diaminopimelate containing) isopentenyl transport aroA -butenyl 4-diphosphate myo-inositol triosephosphate pyruvate methylpropanoyl]dihydrolipoyl-L-lysine uridylate diphosphate cysteine Dihydrolipoyllysine- a peptidoglycan synthase: ispG_gcpE dihydroxyacetoneisomerase: D-glyceraldehyde-tim kinase: formamidopyrimidine- phosphoglycolate Oligopeptidase kinase: 5-enolpyruvyl- synthase ammonium residue (2- phosphate 3-phosphate DNA glycosylase: fpg phosphatase: pgp B: MTRI01113 shikimate-3-phosphate 1-hydroxy-2-methyl-2-(E) phosphoenolpyruvate pvtK A: cysK ammonium MTRI01114 a peptidoglycan Peptidoglycan methylpropanoyl) -butenyl 4-diphosphate synthase: peps Pyruvate transporter: an AP (apurinic or UDP glycosyltransferase: chorismate transferase: MTRI00543 Peptide hydroxymethylbutenyl kinase: amt an [apo BCAA dehydrogenase E2 apyrimidinic) site created glycolate Peptidoglycan synthase: aroC dimethylallyl MTRI03791 pyrophosphate MTRI02411 cys ammonium protein] N 6 -dihydrolipoyl-L-lysine by glycosylic bond cleavage glycosyltransferase: diphosphate 1,3-bisphospho- reductase: ispH_lytB MTRI03791 a peptidoglycan chorismate D-glycerate hydroxymethylbutenyl pyruvate isopentenyl diphosphate a 5-carboxymethylaminomethyl- a single (R)-3- dCMP a peptidoglycan pyrophosphate Phosphoglycerate a polypeptide reductase: ispH_lytB kinase: MTRI03654 2-thiouridine 34 in tRNA stranded DNA hydroxybutanoate tRNA (5- exodeoxyribonuclease 3-hydroxybutyrate cytidylate aminopeptidase 3-phospho-D-glycerate methylaminomethyl- VII, large subunit: xseA dehydrogenase: kinase: cmk N: MTRI02210 (S)-lactate 2-thiouridylate)- exodeoxyribonuclease phbdh methyltransferase: trmU VII, small subunit: xseB dCDP dimethylallyl diphosphate a 5-methylaminomethyl- a double-stranded acetoacetate a polypeptide 2-thiouridine 34 in tRNA oligonucleotide 2-phospho-D-glycerate a DNA D-ribulose- an L-1- acetoacetate enolase: eno phosphatidylethanolamine cyclobutadipyrimidine 5-phosphate Phosphatidylethanolamine Acetoacetate Deoxyribodipyrimidine Phosphoribulokinase: N-methyltransferase: decarboxylase: phosphoenolpyruvate photo-lyase: MTRI03324 MTRI02406 MTRI00510 MTRI01973 pyruvate a phosphatidyl-N- two adjacent pyrimidine D-ribulose-1,5- acetone kinase: pvtK methylethanolamine nucleosides in DNA bisphosphate Pyruvate kinase: MTRI02411

pyruvate

Mg 2+ ammonium

MTRI02599 Amt

Mg 2+ ammonium This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.