The Ocular Surface 15 (2017) A4eA8

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The Ocular Surface

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TFOS DEWS II REPORT - Abbreviations

Acronym/ Definition within TFOS DEWS II report Acronym/ Definition within TFOS DEWS II report abbreviation abbreviation

a-MSH alpha-melanocyte stimulating hormone BIO binocular indirect ophthalmoscope a2-M alpha 2-macroglobulin BiPAP bilevel positive airway pressure 3a-diol-G androstane-3a,17b-diol glucuronide BK bradkinin 5-FU 5-fluorouracil BLA biological license application 5-HT 5-hydroxytryptamine BM bone marrow AA arachidonic acid BPAg bullous pemphigoid antigens ACR American Congress of Rheumatology BPI Brief Pain Inventory ACTB beta actin BSS balanced salt solution ACTH adrenocorticotropic hormone BTX botulinum toxin ADDE aqueous deficient dry eye BW body weight ADT-G androsterone glucuronide C-C cysteine-cysteine AHSCT allogeneic hematopoietic stem cell transplantation C-X-C cystein-an -cysteine AHSG alpha-2-HS- C-X3-C cysteine-any three amino acids-cysteine AIRE autoimmune regulator C3 complement component 3 AK astigmatic keratotomy C4A complement component 4A AKC atopic keratoconjunctivitis CA candidate antigen AKT protein kinase B CAE controlled adverse environment ALA alpha-linolenic acid CAIS complete androgen insensitivity syndrome ALCOA attributable, legible, contemporaneous, original, and accurate CALCA calcitonin related polypeptide alpha ALDH3A1 aldehyde hydrogenase 3A1 CALR calreticulin ALK anterior lamellar keratoplasty CALT -associated lymphoid tissue ANOVA analysis of variance cAMP cyclic adenosine monophosphate anti-M3R Ab type 3 anti-muscarinic acetylcholine receptor antibody CANDEES Canadian Dry Eye Epidemiology Study ANVISA Agencia^ Nacional de Vigilancia^ Sanitaria CASP14 caspase 14 ANXA1 annexin A1 CCD charge-coupled device ANXA11 annexin A11 CCL11 chemokine (C-C motif) ligand 11 ANXA2 annexin A2 CCL15 chemokine (C-C motif) ligand 15 ANXA5 annexin A5 CCL2 chemokine (C-C motif) ligand 2 AOD aerosol optical depth CCL3 chemokine (C-C motif) ligand 3 APC antigen presenting cell CCL4 chemokine (C-C motif) ligand 4 API Active Pharmaceutical Ingredient CCL5 chemokine (C-C motif) ligand 5 APOA2 apolipoprotein A-II CCR chemokine receptor AQP5 aquaporin 5 CCT central corneal thickness ArKO aromatase knockout CD cluster of differentiation ARVO Association for Research in Vision and Ophthalmology CDK climatic droplet keratopathy AS autologous serum CDRH Center for Device and Radiological Health ASGPR asialoglycoprotein receptor CFL1 cofilin 1 ASIC acid-sensing ion channels CFS corneal fluorescein staining AT artificial CGRP calcitonin gene related peptide ATP adenosine triphosphate cGVHD chronic graft-versus-host disease ATS artificial tear solution CH corneal hysteresis AUC area under the curve CHMP Committee for Medicinal Products for Human Use AZGP1 alpha-2-glycoprotein 1 CID clinically important difference AZU1 azurocidin 1 (cationic antimicrobial protein 37) CL contact lens B2M beta-2-microglobulin CLADE contact lens-associated dry eye BAFF B-cell activating factor CLD contact lens discomfort BAK benzalkonium chloride CLDE contact lens-related dry eye BAZ2B bromodomain adjacent to zinc finger domain 2B CLDEQ Contact Lens Dry Eye Questionnaire BCL-2 B-cell lymphoma 2 CLDEQ-8 8-item Contact Lens Dry Eye Questionnaire BCTC N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) CLEERE Collaborative Longitudinal Evaluation of Ethnicity and tetrahydropyrazine-1(2H)-carbox-amide Refractive Error BCVA best corrected visual acuity CLEK Collaborative Longitudinal Evaluation of Keratoconus BDNF brain-derived neurotrophic factor CLIDE contact lens induced dry eye BEST Biomarkers, EndpointS, and other Tools CLIQ Contact Lens Impact on Quality of Life BGE Belmonte's gas esthesiometer CLU clusterin http://dx.doi.org/10.1016/S1542-0124(17)30158-1 1542-0124 TFOS DEWS II REPORT - Abbreviations / The Ocular Surface 15 (2017) A4eA8 A5

Acronym/ Definition within TFOS DEWS II report Acronym/ Definition within TFOS DEWS II report abbreviation abbreviation

CMC carboxymethyl cellulose EGFR epidermal growth factor receptor CME cystoid macular edema EK endothelial keratoplasty CoA coenzyme A EKC epidemic keratoconjunctivitis COBO Cochet-Bonnet esthesiometer ELANE neutrophil elastase COMET cultivated oral mucosal epithelial transplantation ELISA enzyme-likned immunosorbent assay CONSORT CONsolidated Standards Of Reporting Trials EMA European Medicines Agency CPAP continuous positive airway pressure EMMPRIN extracellular matrix metalloproteinase inducer CRD carbohydrate recognition domains EMT epithelial-mesenchymal transition CRF* case report form ENO1 enolase 1 CRF* corneal resistance factor EPA eicosapentaenoic acid CRP C-reactive protein EPO erythropoietin CsA cyclosporine A EPRP eye platelet-rich plasma CSF3 colony stimulating factor 3 (granulocyte) ER endoplasmic reticulum CST1 cystatin SN ERK extracellular signal-regulated kinase CST4 cystatin S ERM ezrin/radixin/moesin CTSB ES effect size CTSS cathepsin S ETDRS Early Treatment Diabetic Retinopathy Study CVA percentage intra-observer variation EU European Union CVI percentage within-subject variation F-WGA fluorescein-labeled wheat germ agglutinin CVSS17 Computer-Vision Symptom Scale F2 coagulation factor II () CX3C class of cytokine that includes fractalkine FBS foreign body sensation CX3CL1 chemokine (C-X3-C motif) ligand 1 FBUT fluorescein breakup time CX3CR1 receptor for fractalkine FDA Food and Drug Administration CXCL10 chemokine (C-X-C motif) ligand 10 FDAAA Food and Drug Administration Amendments Act CXCL11 chemokine (C-X-C motif) ligand 11 FDCA Federal Food, Drug and Cosmetic Act CXCL5 chemokine (C-X-C motif) ligand 5 FED Fuchs' endothelial dystrophy CXCL8 chemokine (C-X-C motif) ligand 8 FES floppy eyelid syndrome CXCL9 chemokine (C-X-C motif) ligand 9 FK fusarium keratitis CXL crosslinking FKN fractalkine (also known as chemokine (C-X3-C motif) ligand 1 DALK deep anterior lamellar keratoplasty (CX3CL1)) DBH dopamine-hydroxylase FL fluorescein DC dendritic cell FLACS femtosecond laser-assisted cataract surgery DCD dermcidin FML fluorometholone DCs dendritic cells fMRI functional magnetic resonance imaging DDEB dominant form of dystrophic EB FN false negatives DED dry FOXO1 forkhead box protein O1 DEEP Dry Eye Epidemiology Project (Questionnaire) FOXP3 forkhead box P3 DEQ Dry Eye Questionnaire FP false positives DEQ-5 5-item Dry Eye Questionnaire FPS Faces Pain Scale DEQS Dry Eye-Related Quality-of-Life Score FSH follicle-stimulating hormone DES desiccating environmental stress FVA functional visual acuity DEWS TFOS Dry Eye Workshop (2007) GABA gamma amino butyric acid DEWS II TFOS Dry Eye Workshop II (2017) GaINAc N-acetyl galactosamine DHA docosahexaenoic acid GalNAc-T GalNAc-transferases DHEA dehydroepiandrosterone Gap43 growth-associated protein 43 DHEA-S dehydroepiandrosterone sulfate GC glucocorticoid DHT dihydrotestosterone GCD goblet cell density DLI donor lymphocyte infusion GCP Good Clinical Practice DLNs draining lymph nodes GCSF granulocyte colony stimulating factor DM diabetes mellitus GDNF glial cell line-derived neurotrophic factor DMBT deleted in malignant brain tumor GFRa3 glial cell line-derived neurotrophic factor family receptor DMC Data Monitoring Committee alpha3 DME diabetic macular edema GH growth hormone DMEK Descemet's membrane endothelial keratoplasty GHA growth hormone antagonist DMPG 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol GHR growth hormone receptor DMSP Defense Meteorological Satellite Program GI gastro-intestinal DN TGFbRII dominant negative TGF-b receptor type II GILZ glucocorticoid-induced leucine zipper DNA deoxyribonucleic acid GIS geographical information systems DPA docosapentaenoic acid GLA gamma-linoleic acid DQSA Drug Quality and Security Act GM-CSF granulocyte-macrophage colony-stimulating factor DRG dorsal root ganglion GMP Good Manufacturing Practice Dsg desmoglein GO Graves' orbitopathy DTH delayed-type hypersensitivity GPC giant papillary conjunctivitis EALT eye-associated lymphoid tissues GPCR G protein coupled receptors EB* epidermolysis bullosa GQL-15 Glaucoma Quality of Life 15-Item EB* essential blepharospasm GR glucocorticoid receptor EBS epidermolysis bullosa simplex GRE glucocorticoid response elements EBV Epstein Barr virus GSK Glaxo Smith Kline ECCE extracapsular cataract surgery GSTP1 glutathione S-transferase pi 1 EDE evaporative dry eye GVHD graft-versus-host disease eDNA extracellular DNA GWAS genome-wide association studies EEC Ectrodactyly, Ectodermal dysplasia, and Clefting HA hyaluronic acid / hyaluronate EFA essential fatty acids HB-LT high background, low threshold EGF epidermal growth factor (continued on next page) A6 TFOS DEWS II REPORT - Abbreviations / The Ocular Surface 15 (2017) A4eA8

Acronym/ Definition within TFOS DEWS II report Acronym/ Definition within TFOS DEWS II report abbreviation abbreviation

HCV hepatitis C virus KOR kappa opioid receptor HGF hepatocyte growth factor LA linolenic acid HHS Health and Human Services LACRT HIS histamine LADD lacrimal-auriculo-dental-digital syndrome HIV human immunodeficiency virus LAIR-1 leukocyte-associated immunoglobulin-like receptor-1 HLA-DR human leukocyte antigen D related LASEK laser epithelial keratomileusis HMG-CoA 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) LASIK laser in situ keratomileusis HNE hydroxynonenal LB-HT low background, high threshold HP haptoglobin LC-MS liquid chromatography-mass spectrometry HPMC hydroxypropyl methylcellulose LCA latent class analysis HRT hormone replacement therapy LCN1 lipocalin-1 HRT/RCM Heidelberg Retina Tomograph with Rostock Module LED light-emitting diode HSCT hematopoietic stem cell transplantation LEF late endothelial failure HSD hydroxysteroid dehydrogenase LEPs late envelope proteins HSPB1 heat shock protein family B (small) member 1 LFA-1 lymphocyte function-associated antigen 1 HSV herpes simplex virus LFU lacrimal functional unit HTLV human T-cell lymphotropic virus LG lacrimal gland HZO herpes zoster ophthalmicus LGALS3 galectin 3 HZV herpes zoster virus LGALS7B galectin 7B i-DDrOP interfacial dewetting and drainage optical platform LGW lacrimal gland weight IASP The International Association for the Study of Pain LH luteinizing hormone IB investigator’s brochure LINE LASIK-induced neurotrophic epitheliopathy ICA independent component analysis LIPCOF lid parallel conjunctival folds ICAM-1 intercellular adhesion molecule 1 (also known as CD54) LK lamellar keratoplasty ICC intra-class correlation LLT lipid layer thickness ICCE intracapsular cataract extraction LP levator palpebrae ICD International Classification of Disease LPS lipopolysaccharide ICH International Council for Harmonisation of Technical LRI limbal relaxing incisions Requirements for Pharmaceuticals for Human Use LSC limbal stem cells ICMJE International Committee of Medical Journal Editors LSCD limbal stem cell deficiency ICRS intrastromal corneal ring segments LTB4 leukotriene B4 IDEEL Impact of Dry Eye on Everyday Life LTF lactoferrin IEC Independent Ethics Committee LWE lid wiper epitheliopathy IFAP ichthyosis follicularis, atrichia, and photophobia LYZ lysozyme IFN interferon M3R antimuscarinic receptor type 3 IFN-g interferon gamma MAC membrane attack complex Ig immunoglobulin MALDI-TOF MS matrix-assisted laser desorption/ionization time-of-flight IGF-1 insulin-like growth factor 1 mass spectrometry IGHa1 immunoglobulin heavy constant alpha 1 MAPK mitogen activated protein kinase IGKV3-20 immunoglobulin kappa variable 3-20 MBTP membrane-bound transcription factor peptidase IGLC2 immunoglobulin lambda constant 2 MC1R melanocortin-1 receptor IHMGECs immortalized human epithelial cells MCID minimum clinically important difference IL interleukin MCJ mucocutaneous junction IL-1Ra interleukin-1 receptor antagonist MDN1 midasin homolog IL16 interleukin 16 (lymphocyte chemoattractant factor) MEMS Medication Event Monitoring System IL1R1 interleukin 1 receptor, type I (soluble) MG meibomian gland IL1RN interleukin 1 receptor antagonist MGD meibomian gland dysfunction IL-1a interleukin 1 alpha MGH 40 macrogolglycerol hydroxystearate 40 IL-1b interleukin 1 beta MGYLS meibomian glands yielding lipid IL6Ra interleukin 6 receptor alpha MHC major histocompatibility complex IL6ST interleukin 6 signal transducer MIF macrophage migration inhibitory factor IND Investigational New Drug MiHA minor histocompatibility antigen INF-g-IP interferon gamma-induced protein miRNAs microRNAs IOL intraocular lens MIT meniscus induced thinning IOP intraocular pressure MMC mitomycin-C IR* immunoreactivity MMF mycophenolate mofetil IR* insulin receptor MMP matrix metalloproteinase IRB Institutional Review Board MMP-9 matrix metalloproteinase-9 IRR* incidence rate ratio MODIS Moderate Resolution Imaging Spectroradiometry IRR* innate repair receptor MPQ McGill Pain Questionnaire IRS insulin receptor substrate MPS multipurpose solutions iTRAQ isobaric tag for relative and absolute quantitation MQ McMonnies Questionnaire IVCM in vivo confocal microscopy MRKC meibomitis-related keratoconjunctivitis JAK2 Janus-kinase 2 mRNA messenger RNA JAMA Journal of the American Medical Association MRSA methicillin-resistant staphylococcus aureus JCHAIN joining chain of multimeric IgA and IgM MRSE methicillin-resistant staphylococcus epidermidis JEB junctional epidermolysis bullosa MS mass spectrometry JNK c-Jun N-terminal kinase MS/MS tandem mass spectrometry Kþ potassium MSC mesenchymal stem/stromal cells KCS keratoconjunctivitis sicca MSG minor salivary gland kDa kilodalton mTOR mechanistic target of rapamycin KFSD keratosis follicularis spinulosa decalvans MUC mucin Klk kallikrein MUC1 mucin-1 KO knockout MUC1-CT cytoplasmic tail of mucin 1 TFOS DEWS II REPORT - Abbreviations / The Ocular Surface 15 (2017) A4eA8 A7

Acronym/ Definition within TFOS DEWS II report Acronym/ Definition within TFOS DEWS II report abbreviation abbreviation

Naþ sodium PRK photorefractive keratectomy NaCl sodium chloride / saline PRO patient-reported outcome NaV channel voltage-gated Naþ channel PROL1 proline rich, lacrimal 1 NDA new drug application PROSE prosthetic replacement of the ocular surface ecosystem NEI National Eye Institute PRR4 proline rich 4 (lacrimal) NEI VFQ-25 National Eye Institute 25-Item Visual Function Questionnaire PRRs pattern recognition receptors NETs neutrophil extracellular traps PRT phenol red thread

NFKB nuclear factor KB PSI pounds per square inch NGF nerve growth factor (beta polypeptide) pSS primary Sjogren€ syndrome NI non-inferiority PTGER3 prostaglandin E receptor 3 NIBUT non-invasive breakup time PUFA polyunsaturated fatty acid NIH National Institutes of Health PV pemphigus vulgaris NIV noninvasive ventilation PVA polyvinyl alcohol NK neurotrophic keratopathy PVP polyvinylpyrrolidone NK cells natural killer cells QOL quality of life NLR NOD-like receptor qPCR quantitative polymerase chain reaction NMDA N-methyl-D-aspartate R1 blinking short latency blinking response NMR nuclear magnetic resonance response NO nitric oxide R2 blinking long latency blinking response NOAEL no-observed-adverse effect level response NOD non-obese diabetic RA* retinoic acid NOMGD non-obvious MGD RA* rheumatoid arthritis NPY neuropeptide Y RAGs regeneration-associated NR not reported RAS renin-angiotensin system NRS numeric rating scale RCT randomized controlled trial NSAID non-steroidal anti-inflammatory drug RCV reference change value NSDE non-Sjogren€ dry eye RDEB recessive form of dystrophic EB NTs neurotrophins RH relative humidity o/w oil-in-water RIAT restoring invisible and abandoned trials OAHFAs O-acyl-u-hydroxy fatty acids RK radial keratotomy OCI Ocular Comfort Index RNA ribonucleic acid OCP ocular cicatricial pemphigoid ROC receiver operating characteristic OCT optical coherence tomography ROCK Rho-associated kinase OO orbicularis oculi ROS reactive oxygen species OPAS Ocular Pain Assessment Survey RREB1 ras responsive element binding protein 1 (zinc finger motif OPI Ocular Protection Index enhancer-binding protein 1) OPN osteopontin RTx radiation treatment OR odds ratio S100A11 S100 calcium binding protein A11 (calgizzarin) ORM1 orosomucoid 1 S100A12 S100 calcium-binding protein A12 (calgranulin C) ORM2 orosomucoid 2 S100A4 S100 calcium binding protein A4 OSAHS obstructive sleep apnea hypopnea syndrome S100A6 S100 calcium binding protein A6 (calcyclin) OSD ocular surface disease S100A7 s100 calcium binding protein A7 (psoriasin) OSDI Ocular Surface Disease Index S100A8 S100 calcium binding protein A8 (calgranulin A) OTC over-the-counter S100A9 S100 calcium binding protein A9 (calgranulin B)

P2X7 P2X purinoreceptor 7 SAC seasonal allergic conjunctivitis PAC perennial allergic conjunctivitis SANDE Symptom Assessment in Dry Eye PCF pharyngoconjunctival fever SAS statistical analysis software PCR polymerase chain reaction SBUDE short breakup time DED PD Parkinson's disease SC secretory component PEBP1 phosphatidyl-ethanolamine binding protein 1 SCGB1D1 secretoglobin family 1D member 1 (lipophilin A) PEK punctate epithelial keratopathy SCGB1D2 secretoglobin, family 1D, member 2 PEX pseudoexfoliation SCGB2A1 secretoglobin, family 2A, member 1 (mammaglobin B, PF preservative-free mammaglobin 2 & lipophilin C) PG prostaglandin SCGB2A2 secretoglobin, family 2A, member 2 PI3K phosphoinositide 3-kinase SCP scopolamine pIgR polymeric immunoglobulin receptor (secretory component) SD standard deviation PIP prolactin-induced protein SELDI-TOF-MS surface-enhanced laser desorption/ionization -time of flight- pk parakeratinised mass spectrometry PK penetrating keratoplasty SelP selenoprotein P PL phospholipids SERPINA1 serpin peptidase inhibitor clade A member 1 PLA2G2A group IIA phospholipase A2 SESoD Subjective Evaluation of Symptom of Dryness PLAA phospholipase A2-activating protein SF-36 Short Form-36 PLC phospholipase C SGK1 serum and glucocorticoid regulated kinase 1 PLDE post-LASIK dry eye sIgA secretory IgA PLG plasminogen SiHy silicone hydrogel PLL-g-PEG poly(l-lysine)-graft-poly(ethylene glycol) SJS/TEN Stevens-Johnson syndrome/toxic epidermal necrosis PMA post-market approval SLE systemic lupus erythematosus PMMA polymethyl methacrylate SLET simple limbal epithelial transplantation PMN polymorphonuclear leukocyte SLK superior limbic keratoconjunctivitis POTEI POTE Ankyrin Domain Family Member I SMARCA4 transcription activator BRG1 PPAR peroxisome proliferator-activated receptor SMILE small incision lenticule extraction PPV* pars plana vitrectomy SMR3B submaxillary gland androgen regulator protein 3B PPV* positive predictive value SNPs single-nucleotide polymorphisms PRDX5 peroxiredoxin 5 (continued on next page) A8 TFOS DEWS II REPORT - Abbreviations / The Ocular Surface 15 (2017) A4eA8

Acronym/ Definition within TFOS DEWS II report Acronym/ Definition within TFOS DEWS II report abbreviation abbreviation

SOD superoxide dismutase TNF-a tumor necrosis factor alpha SP substance P TNFRSF1B soluble TNF receptor superfamily member 1B SP-D surfactant protein-D TP true positives SPEED Standard Patient Evaluation of Eye Dryness Treg regulatory T cells SPK superficial punctate keratitis TREK A member of the two-pore-domain family of potassium SPPR2A small proline-rich protein 2A channels Sprr1A small proline-rich repeat protein 1A TrkA tropomyosin receptor kinase A SPRRs small proline-rich proteins TRP channels transient receptor potential channels SREBPs sterol regulatory element binding proteins TRPA1 channels transient receptor potential cation channel subfamily A SS Sjogren€ syndrome member 1 SSDE Sjogren€ syndrome dry eye TRPM8 transient receptor potential member 8 sSS secondary Sjogren€ syndrome TRPV1 transient receptor potential vanilloid type 1 STATs signal transducers and activators of transcription TS-1® tegafur gimeracil oteracil potassium SUSAR Serious Unexpected Suspected Adverse Reactions TSG-6 TNF-stimulated gene/protein-6 SV40 simian virus 40 TSH -stimulating hormone SVW seminal vesicle weight TSP-1KO thrombospondin knockout TACR1 tachykinin receptor 1 TTO tea tree oil TAO thyroid-associated orbitopathy TTR tear turnover rate TBNC trigeminal brain stem nuclear complex TTX tetrodotoxin TBUT tear breakup time Tubb3 beta III tubulin TCN1 transcobalamin I UNC DEMS University of North Carolina Dry Eye Management Scale TEN toxic epidermal necrosis US United States TF transferrin USA United States of America TFF3 trefoil factor family peptide 3 USD United States Dollar TFLL tear film lipid layer UV ultraviolet Tfm testicular feminized UVA ultraviolet A TFOS Tear Film and Ocular Surface Society VA visual acuity Tg transgenic VAS visual analog scale TG trigeminal ganglion VDR vitamin D receptor TGF transforming growth factor VDT visual display terminal TGF-a transforming growth factor alpha VDU visual display units TGF-b transforming growth factor beta VEGF vascular endothelial growth factor TGM2 VIP vasoactive intestinal peptide TH* tyrosine hydroxylase VKC vernal keratoconjunctivitis TH* thyroid hormone VMO1 vitelline membrane outer layer protein 1 homolog TLRs toll-like receptors VNTR variable number of tandem repeats TLS tertiary or ectopic lymphoid structures WHO World Health Organization Tm melting temperature WHS Womens Health Study TMA tear meniscus area YFP yellow fluorescent protein TMH tear meniscus height ZG16B zymogen granule protein 16B TMR tear meniscus curvature (radius) * Caution: Consider context as more than one definition is provided for this entry TN true negatives TNF tumor necrosis factor