FERUARY 2015 NEWSLETTER from the Institute for Engineering in Medicine

. Otto Schmitt Distinguished Lecture, Dr. Marcus Raichle March 3rd . Minnesota Neuromodulation Symposium April 16-17 . Design of Medical Devices Conference April 13-16 . Nanoengineering for Medicine & Biology Conference April 19-22 . BioCoR Short Course Programs May 19-20 & May 20-21 . IEM Clinical Immersion Program for Non-Clinicians

News

The Otto Schmitt Distinguished Lecture Series – Dr. Marcus Raichle The Restless Brain: How Intrinsic Activity Organizes Brain Function

March 3, 2015 Networking lunch starting at 11:30AM, Presentation 12:00PM – 1:15PM Mayo Auditorium Minneapolis, MN

This event is free, and open to the public!

The Institute for Engineering in Medicine is pleased to announce the next session of the Otto Schmitt Distinguished Lecture Series with a presentation by Dr. Marcus Raichle, “The Restless Brain: How Intrinsic Activity Organizes Brain Function”.

Offered quarterly, this series is open to the University of Minnesota community to build collaborative projects between the disciplines of engineering and medicine, as well as provide an opportunity to hear presentations from national opinion leaders in research, industry, and government.

Dr. Marcus Raichle is the Alan A. and Edith L. Wolff Distinguished Professor in Medicine at Washington University in St Louis and member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences and is a Fellow of the American Association for the Advancement of Science. He was also the 2014 recipient of the Kavli Prize in Neuroscience awarded by the Norwegian Academy of Science and Letters.

Dr. Raichle and his group have consistently led in defining the frontiers of cognitive neuroscience through the development and use of functional brain imaging techniques. He and his colleagues have made outstanding contributions to the study of human brain function through the development and use of positron emission tomography and functional magnetic resonance imaging. Their landmark study (Nature, 1988) described the first integrated strategy for the design, execution and interpretation of functional brain images.

Dr. Raichle’s presentation “The Restless Brain: How Intrinsic Activity Organizes Brain Function” will take place March 3, 2015 at the 4th floor Mayo Auditorium. Free lunch will be provided during the networking session from 11:30am – 12:00pm, followed by Dr. Raichle’s presentation from 12:00pm – 1:15pm. Due to limited seating, early arrival is recommended.

Additional information on Dr. Raichle’s presentation, as well as the Otto Schmitt Distinguished Lecture Series can be found through the following link: Otto Schmitt Distinguished Lecture Series

Dr. Matthew Johnson Receives McKnight Land-Grant Professorship Dr. Matthew Johnson, Assistant Professor of Biomedical Engineering, and member of the Institute for Engineering in Medicine, was awarded the designation of McKnight Land-Grant Professor for the years of 2015 – 2017.

Bridging engineering and neuroscience disciplines, Dr. Johnson’s research is being recognized for building a principled understanding for how to target electrical stimulation within the brain to correct abnormal patterns of neural activity. Using these principles, he is creating new neural interface technology to more precisely modulate networks of neurons within the brain to ultimately improve the clinical care of individuals with neurological and neuropsychiatric disorders. 2015-2017 McKnight Land-Grant Professors

Dr. Robert Tranquillo Elected IAMBE Fellow Dr. Robert Tranquillo, Distinguished McKnight University Professor and Head of the University of Minnesota’s Department of Biomedical Engineering, and member of the Institute for Engineering in Medicine, was elected a Fellow of the International Academy of Medical and Biological Engineering (IAMBE), in honor of his distinguished contributions to and leadership in the field of medical and biological engineering at an international level.

Every year existing fellows of the academy vote on new members who have been nominated and screened by the academy membership committee. IAMBE also offers an Early Career Award which is used to encourage and support young researchers as they develop their careers. Additional information on IAMBE, as well as a list of current fellows can be found on their website. IAMBE Website

The Drone Revolution Is Going Mainstream – U of MN Study Featured on ‘Good Morning America’ ABC Good Morning America published a story on the drone phenomenon, and featured the University of Minnesota’s BCI study, led by Institute for Engineering in Medicine Director, Dr. Bin He. The BCI study featured in the video news piece demonstrates how brainwaves through an EEG cap are used to control a flying robot. Monitoring electrical activity from the brain, the 64 scalp electrodes of the EEG cap report the signals (or lack of signals) they detect to a computer, which translates the pattern into an electronic command. ABC Good Morning America commented on how drone technology is changing the way people interact with the world around them, and says that the sky is the limit. Dr. He’s BCI study aims to apply the flying robot technology to help disabled patients interact with the world. ABC Good Morning America | Mind Over Mechanics

Daily Low-Dose Aspirin for Heart Attack Prevention Dr. Alan T. Hirsch, Professor of Medicine, Director of the University of Minnesota’s Vascular Medicine Program, and IEM Member, is leading a study that aims to minimize the rate of stroke and heart attack in groups of people that are of moderate to high risk–men age 45 to 79 and women age 55 to 79.

The result of a trial version of this study was that the proportion of the people in the targeted population who took a low-dose aspirin rose from 36 percent to 54 percent in four months, helping them better manage their health. In article recent article published in the StarTribune, Dr. Hirsch explains that this was a higher percentage increase than expected, and that if this same pattern could be achieved statewide, as many as 7,000 first heart attacks and strokes a year could be prevented over the next five years. Dr. Hirsch also emphasized the importance of individuals to first determine with their doctor if they have the right heart risk rate and the lowest bleeding risk before committing to the program. U of MN to expand low-dose aspirin campaign as stroke, heart attack prevention

U of MN Collaboration with Industry – Innovative Approach to Fighting Cancer Dr. Perry Hackett, Professor of Genetics, Cell Biology and Development, and IEM Member, developed, with his international team, a DNA-based gene delivery platform called “Sleeping Beauty” (SB). This genetic technology, combined with University of Texas’ M.D. Anderson Cancer Center’s cancer therapies, has resulted in a $100 million licensing deal with Intrexon Corp., a biotech company, and Ziopharm Oncology, a pharmaceutical company. Instead of designating royalties to be paid after the launch, the licensing deal arranged for the University of Minnesota to be paid up-front for the use of the non-viral gene therapy treatment technology. A portion of these funds will be used to provide substantial support for future research at the university. Dr. Hackett states that it’s an exciting victory for genome engineering technology — one that promises a sigh of relief from sufferers of many genetic diseases. Industry, university deal moves novel cancer treatment forward Nasdaq: Intrexon, ZIOPHARM, and MD Anderson in Exclusive CAR T Pact

Minnesota Black Bear Research Partnership with Medtronic – Preserving Organs and Preventing Clots Dr. Paul Iaizzo, Associate Director for Education and Outreach, Institute for Engineering in Medicine, and Professor of Surgery; Integrative Biology and Physiology; and the Carlson School of Management, was featured in an article by Legacy Magazine discussing his ongoing partnership with Medtronic Inc., on his Minnesota Black Bear research.

Dr. Iaizzo, with the collaboration of Tim Laske, Vice President of Research and Development of Medtronic AF Solutions, and U of MN scientist Dr. Tinen Iles, is studying black bear hibernation and how components of hibernation could prevent the risk of blood clots in sedentary humans. Dr. Iaizzo is also investigating how components of hibernation induction triggers can be used in human patients in order to increase the functioning of affected tissues or to preserve organs that are to be used in transplant surgery. Dr. Iaizzo states that Medtronic’s support allows for the training of undergraduate and graduate medical students, promotion of medical careers to young children, better understanding of cardiac health, and the development of black bear research. From the lab to the north woods

2015 – 2016 IEM Interdisciplinary Doctoral Fellowship Recipients The Institute for Engineering in Medicine is pleased to host two University of Minnesota Interdisciplinary Doctoral Fellows in 2015-2016. Fellows are selected for this honor through the University’s Graduate School, allowing them to benefit from interaction with faculty at one of the University’s interdisciplinary research centers or institutes. IEM would like to congratulate this year’s recipients.

Julia Quindlen Department of Biomedical Engineering “Mechano-to-neural Transduction of the Pacinian Corpuscle” Mentors: Drs. Victor Barocas and Martha Flanders

Kathryn Geldart Department of Chemical Engineering “Engineering Antibiotic Probiotics for the Treatment of Vancomycin-Resistant Enterococcus” Mentors: Drs. Yiannis Kaznessis and Gary Dunny

Announcements

The 3rd Annual Minnesota Neuromodulation Symposium April 16-17, 2015 Commons Hotel Minneapolis, MN

The 3rd Annual Minnesota Neuromodulation Symposium (http://neuromodulation.umn.edu) will be held April 16-17, 2015 (from 2:00 PM April 16th) at the Commons Hotel in Minneapolis immediately following the Design of Medical Devices Conference.

Organized by the University of Minnesota’s Institute for Engineering in Medicine, this symposium highlights recent advances in the field of neuromodulation, showcasing presentations from internationally recognized leaders in academia, industry, and government. Networking opportunities will be made available as well throughout the two days to help facilitate energetic discussions on the most recent topics in Neuromodulation.

Poster Presentations and Travel Awards: We invite researchers, educators, and clinicians to submit abstracts for any topic relating to neuromodulation, including invasive and noninvasive techniques, modeling, neurophysiology, behavior, new technologies, clinical applications, and education/training approaches. All abstracts will be peer reviewed, and accepted abstracts will be e-published. There will be a poster competition for all non-faculty presenters in which the top posters will be awarded with a certificate and monetary prize at the Closing Ceremony on April 17th. We will select one 1st place, two 2nd place, and three 3rd place winners ($500, $300, $200, respectively). Ten travel awards will also be made available of up to $500, each, for national and international students, and postdoctoral researchers presenting posters at the Symposium. The deadline for abstract and travel award submissions is March 2, 2015.

Abstract Submission | Travel Award

Invited Speakers (confirmed):

Mahlon R. DeLong, MD Professor of Neurology Emory University School of Medicine Member, Institute of Medicine Lasker-DeBakey Clinical Medical Research Awardee

Tim Fayram Vice President of Research St. Jude Medical

John LaLonde Vice President, Research, Technology & Development Medtronic Neuromodulation

Sarah Hollingsworth Lisanby, MD J.P. Gibbons Professor and Chair, Department of Psychiatry and Behavioral Sciences Professor, Department of Psychology and Neuroscience Duke University

Michael A. Nitsche, PhD Associate Professor of Clinical Neurophysiology Georg-August-University, Goettingen, Germany

P. Hunter Peckham, PhD Donnell Institute Professor of Biomedical Engineering and Distinguished University Professor Case Western Reserve University Member, National Academy of Engineering

Shoogo Ueno, PhD (Dr. Eng.) Professor, Department of Applied Quantum Physics Kyushu University, Japan

Jerrold L. Vitek MD, PhD Professor and Head of the Department of Neurology University of Minnesota

Registration: The event was sold out last year due to limited sitting. In order to secure your place at this year’s program, please register ASAP through the following link: Registration

2015 Design of Medical Devices Conference April 13-16, 2015 Commons Hotel and MacNamara Alumni Center Minneapolis, MN

The University of Minnesota’s Medical Devices Center (part of the Institute for Engineering in Medicine), the College of Science and Engineering, and the Academic Health Center presents the 14th Annual Design of Medical Devices Conference, April 13-16, 2015. The world’s largest medical device conference will be held at The Commons Hotel & McNamara Alumni Center, located on the University of Minnesota Twin Cities Campus.

Keynote and featured speakers scheduled to appear include: Susan Alpert, SFA Consulting LLC Phil Ebeling, St. Jude Medical Igor Efimov, Washington University John Evans, Tractus Dan Johnson, Levo Standing Wheelchair Company John Mack, Medtronic Coronary and Structural Heart Disease Management Todd McAlistar, Cytograft Tissue Engineering, Inc. Andy Phahnl, Devicix John Rogers, College of Engineering, University of Illinois Urbana-Champaign Leslie Saxon, University of Southern California Randall Schiestl, Boston Scientific Corporation Jesus Soriano, National Science Foundation Sze Wee Wan, Agency for Science, Technology and Research (A*STAR)

Visit the conference website to view the Current Program and Registration information.

DMD Conference Hotel Room Block A block of rooms has been reserved at the University Hotel Minneapolis. Please plan to make your reservation before the deadline on Thursday, March 12, 2015. Accommodations

DMD Sponsorship Opportunities Available The mission of the Design of Medical Devices conference is to facilitate collaboration between academia and industry. Exhibit Space is limited. To learn more, contact Jenny Holden, Conference Administrator at [email protected].

ASME 2015 4th Annual Global Conference on Nanoengineering for Medicine and Biology (NEMB 2015) April 19-22, 2015 Commons Hotel and MacNamara Alumni Center Minneapolis, MN

Mark your calendar for ASME’s 2015 Global Conference on Nanoengineering for Medicine and Biology (NEMB) which is taking place April 19-22, 2015 in Minneapolis.

There is a packed schedule with stellar plenary speakers who will discuss nanoscale materials, methods, and devices for the study of biology and the treatment of disease:

Speakers: Rashid Bashir, University of Illinois at Urbana Champaign Shuichi Takayama, University of Michigan Lihong Wang, Washington University in St. Louis Paul Weiss, UCLA Denis Wirtz, Johns Hopkins University Susan Wolf, University of Minnesota

Visit NEMB 2015 for full track listing and details on speakers, sponsorship, and registration: NEMB 2015

BioCoR Short Course Programs – Preservation of Molecular, Cellular, and Tissue Biospecimens; Preservation of Cellular Therapies May 19-20, and 20-21, 2015 Minneapolis, MN (With simultaneous webcast) Early registration ends April 17, 2015.

In May 2015, the University of Minnesota’s Biopreservation Core Resource (BioCoR) is offering two back- to-back short courses, Preservation of Molecular, Cellular, and Tissue Biospecimens, and Preservation of Cellular Therapies. Individuals registering for both courses will receive a discount. Two or more individuals from the same organization registering for a single course will also receive a discount. Please contact [email protected] for more details.

Preservation of Molecular, Cellular, and Tissue Biospecimens Short Course: May 19-20, 2015 Biospecimens are macromolecules (DNA, proteins, enzymes, etc.), cells, tissues, and bodily fluids that are used for diagnostic, therapeutic, and epidemiologic purposes. The ability to maintain the critical biological characteristics of the biospecimen during transit and storage is critical for its use. Participants in the course will be introduced to the fundamentals of preservation, protocol development, repository design, documentation and validation of preservation protocols and regulatory issues. Schedule of lectures – May 19-20, 2015 | Registration

Preservation of Cellular Therapies Short Course: May 20-21, 2015

Currently 1.2 million patients are receiving treatment from regenerative medicine products produced by 171 companies. Preservation issues are critical, in particular, for cell therapy clinical trials. Cells used therapeutically, are typically processed in specialized facilities and the cell must be preserved as they are shipped between the site of manufacture and the site of use. Preservation permits coordination between the manufacture of the therapy and patient care regimes. Finally, effective methods of preserving the cell therapy permit time for completion of safety and quality control testing. Come learn about fundamentals of preservation, protocol development, design of a storage facility, regulatory issues associated with preservation of cell therapies, clinical issues and more. Schedule of lectures – May 20-21, 2015 | Registration

IEM Clinical Immersion Program for Non-Clinicians March 30 – April 3, 2015 Minneapolis, MN

Cost: $5,000/week (Funds will be used to support research programs for Surgical residents)

The Institute for Engineering in Medicine (IEM) Clinical Immersion Program for Non-Clinicians is tailored towards professionals within the medical device community looking to move outside of the design suite and into the surgical suite — an environment where their products are used on a day-to-day basis.

Participants in the program will undertake a week long course observing various surgeries, while receiving formal training in a clinical setting on processes, policies, and procedures relating to a variety of healthcare situations. A minimum of 5 participants are needed per rotation, with a maximum of 8. Once registration is full, teams will be placed on a waiting list for future rotations. Private groups can be arranged for companies looking to send full teams. Please contact the Institute for Engineering in Medicine for questions relating to the program, or inquiries about tailoring the program to meet specific goals.

For registration information please contact: IEM office (612) 624-8483 [email protected] www.iem.umn.edu

5th Summer School on Neurorehabilitation (SSNR2015) September 13 - 18, 2015 El Saler, Valencia, Spain

SSNR2015 will provide in depth education on advanced procedures for neurorehabilitation of motor dysfunction following stroke, SCI, CP and other neurological conditions, covering practical applications based on neuroprosthetics, robotics interfaces and other combinational and technological approaches. World-class experts in various related disciplines will deliver plenary talks and a set of hands-on workshops will be organized.

Registration: Prospective applicants must fill in the Application Form by May 15, 2015. The admission to the School will be decided upon a selection made by the General Conference Committee.

Applications received before March 31, 2015 will be given priority. The General Conference Committee will select a first group among these early applications. Selected participants will be notified by April 15, 2015 and the registrations must be completed before May 15, 2015.

Remaining positions will be allocated among the rest of applications received until May 15, 2015.

Plenary Speakers: Metin Akay, University of Houston, USA José Carmena, University of California, Berkeley Gregoire Courtine, Swiss Federal Institute of Technology (EPFL), Switzerland Volker Dietz, Balgrist University Hospital, Switzerland Bernhard Graimann, Otto Bock HealthCare GmbH, Germany David Guiraud, INRIA research scientist, leader of DEMAR team, France Bin He, University of Minnesota, USA Ilse Jonkers, Katholieke Universiteit Leuven, Belgium Hermano Igo Krebs, Massachusetts Institute of Technology, USA Silvestro Micera, ARTS and CRIM Labs, Scuola Superiore Sant’Anna, Italy Eric Perreault, Northwestern University, USA Dejan Popovic, University of Belgrade, Serbia Zev Rymer, Northwestern University, USA Aiko K. Thompson, Medical University of South Carolina, USA Jonathan Wolpaw, Wadsworth Center, New York State Dept. of Health and State, University of New York

For further and up-to-date information, please visit the conference website: www.ssnr2015.org

Call for Abstracts – IWSP7: Epilepsy Mechanisms, Models, Prediction & Control The 7th International Workshop on Seizure Prediction (IWSP7: Epilepsy Mechanisms, Models, Prediction & Control) will bring together world leading epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists to focus on epilepsy research in Melbourne Australia from 3-6 August 2015.

Invited Speakers: Samuel Berkovic, University of Melbourne, Australia (Genetics and individual-specific nature of epilepsy) Bin He, University of Minnesota, USA (EEG-based imaging to localize seizure and high frequency activity) Louis Lemieux, University College London, UK (Multi-modal imaging of human epileptic zone and networks) Martha Morrell, Stanford University, Neuropace, USA (Responsive seizure control and its clinical implications) Philippe Ryvlin, Lyon University, France (Vagal nerve stimulation and seizure prediction) John Terry, University of Exeter, UK (Modelling multiscale brain networks: seizure initiation, evolution and prediction) Gregory Worrell, Mayo Clinic, USA (Forecasting epileptic seizures in dogs)

Abstract submission deadline: April 16th, 2015. Notification of acceptance: May 31st, 2015.

Early bird registration: full: AU$465; Student/Early Career Researcher: AU$165. Early bird registration deadline: June 30th, 2015. Standard registration: full: AU$565; Student/Early Career Researcher: AU$265.

Over 30 generous travel stipends will be awarded with the majority going to students and early career researchers.

Topics for abstracts include, but are not limited to: seizure prediction, detection and control; seizure mechanisms, animal models and human neurophysiology; neuroimaging of epilepsy/seizure localization; computational modeling of epilepsy; epilepsy networks; high frequency oscillations; model-based estimation, statistical signal processing or control theory applied to epilepsy.

For information on invited speakers and the preliminary conference program, and how to submit abstracts and register visit: www.iwsp7.org

Funding Opportunities

National Institutes of Health - New SPARC Funding Opportunity The NIH Common Fund Program on Stimulating Peripheral Activity to Relieve Conditions (SPARC) has released its first request for applications, RFA-RM-15-002: Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18). The RFA solicits applications to develop new and/or enhance existing tools and technologies tailored to elucidate the neurobiology and neurophysiology underlying autonomic control of internal organs in health or disease, to inform next generation neuromodulation therapies.

SPARC is uniquely positioned to serve as a community resource that provides the broader public and private research communities with the scientific foundation necessary to create more effective and minimally invasive neuromodulation therapies. The program has the central goal of providing a basic understanding of the peripheral nervous system to catalyze development of new or more efficacious therapies based on neuromodulation of end-organ system function. This first step will support exploratory studies to develop a broad range of technologies, spanning sensing to stimulation to surgical techniques to model systems. The 2 year awards resulting from this FOA will establish feasibility for further technology development and lay the groundwork to more systematically facilitate biological mapping activities in future SPARC initiatives.

Detailed in the FOA, the cooperative agreement mechanism will involve active participation in SPARC program events and NIH partnership in supporting and stimulating the recipients’ activities.

Letter of Intent Deadline - March 14, 2015 Application Deadline - April 14, 2015

Please contact: [email protected] with any questions regarding this funding opportunity.