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A Successful Intra-Pleural Fibrinolytic Therapy with Alteplase in a Patient with Empyematous Multiloculated Chylothorax

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A Successful Intra-Pleural Fibrinolytic Therapy with Alteplase in a Patient with Empyematous Multiloculated Chylothorax CASE REPORT East J Med 24(3): 379-382, 2019 DOI: 10.5505/ejm.2019.72621 A Successful Intra-Pleural Fibrinolytic Therapy With Alteplase in A Patient with Empyematous Multiloculated Chylothorax Mohamed Faisal1*, Rayhan Amiseno1, Nurashikin Mohammad2 1Respiratory Unit, Universiti Kebangsaan Malaysia Medical Centre, Malaysia 2Medical Department, Universiti Sains Malaysia ABSTRACT Chylothorax is a collection of chyle in the pleural cavity resulting from leakage of lymphatic vessels, usually from the thoracic duct. In majority of cases, chylothorax is a bacteriostatic pleural effusion. Incidence of infected or even empyematous chylothorax are not common. Here, we report a case of a 57-year-old man with end stage renal disease and complete central venous stenosis who presented with recurrent right-sided chylothorax. It was complicated with sepsis and multilocated empyema and treated successfully with intra-pleural fibrinolytic therapy using alteplase. Key Words: Chylothorax, empyema, intrapleural fibrinolysis Introduction effusions and empyema in the adult population for the outcomes of treatment failure (surgical Chyle is a non-inflammatory, bacteriostatic fluid intervention or death) and surgical intervention with a variable protein, fat and a lymphocyte alone (4). Our patient had chylothorax which was predominance of the total nucleated cells. (1,2) complicated with empyema and treated with Incidence data are available for only post- combination of intravenous antibiotic and operative chylothorax, which can occur after sequential intra-pleural alteplase (without almost any surgical operation in the chest. It is deoxyribonuclease) administered to different most often observed after esophagectomy (about pleural locules. 3% of cases), or after heart surgery in children (up to about 6% of cases) (1). It is uncommon for Case Report chylothorax to be infected and loculated (2). Chylothoraxis a condition that needs to be taken Our patient is a 57-year-old man with end stage seriously; a patient who persistently loses chyle renal failure due to long standing hypertension; will be losing considerable amounts of fat and fat- dyslipidaemia and ischaemic heart disease. He soluble vitamins, proteins, electrolytes, attended regular dialysis 3 times per week using immunoglobulins, and T-lymphocytes, with right brachiocephalic (BCV) fistula. He had resulting malnutrition, weight loss, and an multiple admissions to hospital for thrombosed impaired immune system. (1) The management of loop graft and veno-thromboplasty between 2011 chylothorax depends on the underlying cause and to 2015. In early 2015, computed tomography most of the cases were treated conservatively(1-2). (CT) scan of thorax showed complete occlusion of Empyematous chylothorax on the other hand left brachiocephalic subclavian vein with well- should be treated more aggressively. Many of established collaterals and severe stenosis (95%) these patients will require antibiotics, of right BCV with multiple collaterals. But he thoracoscopic or open debridement and remained asymptomatic during that period. drainage.[3] Intra-pleural fibrinolytic therapy In November 2016, he was admitted to a district (IPFT) has been established as one of potentially hospital due to progressive shortness of breath beneficial treatment option for parapneumonic which turned out to be massive right-sided *Corresponding Author: Mohamed Faisal Abdul Hamid, Respiratory Unit, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. E-mail: [email protected], [email protected] Received: 22.10.2018, Accepted: 04.12.2018 Faisal et al / Empyematous Multiloculated Chyolothorax Fig.1. Chest radiograph showed massive right-sided pleural effusion Fig.2.a,b. CT scan thorax axial view (a) showed multiloculated right-sided pleural effusion with split pleural sign. CT Scan thorax coronal view (b) revealed a multiloculated pleural effusion with chest drain in-situ at the right lower lobe chylothorax. He was referred to our center for with respiratory rate 30/min, heart rate was further management. CT scan of thorax showed 110/min and febrile at 38 degrees with blood complete central venous stenosis with established pressure of 85/50 mmHg. He had reduced breath collaterals. A subsequent CT lymphagiogram sounds and stony dullness over the right lung. revealed termination of lipiodol opacification in Chest radiograph showed massive right-sided the lymph nodes and lymphatic vessel at level of pleural effusion (figure 1A). A bed side thoracic right third thoracic vertebrae (T3) and left 5th ultrasound showed multiseptated, multiloculated thoracic vertebrae (T5). Pigtail-catheter (8F) was right pleural effusion. The blood investigations inserted to drain the chylothorax and he was showed leukocytosis with total white cell count subsequently scheduled for lymphovenous bypass (TWCC) was 31x109 and C-reactive protein (CRP) surgery in february 2017. was 26.54 mmol/L. Unfortunately, he had recurrence of the Pleural fluid was milkish in colour. Biochemistry chylothorax while waiting for surgery and during of the pleural fluid revealed LDH: 1147 mmol/L), one of the admission; he was discharged with and triglyceride of 9.6 mmol/L (849.5 mg/dL), pigtail catheter. Two weeks later, he presented with pH of 7.0. Pleural fluid bacterial culture, with septicaemia. He reported poor drainage from Mycobacterium Tuberculosis culture and AFB the pigtail catheter. Clinically, he was tachypneic were negative. East J Med Volume:24, Number:3, July-September/2019 380 Faisal et al / Empyematous Multiloculated Chyolothorax Fig. 3. a,b,c.Chest radiograph (A) after the first administration of intra-pleural alteplase to lower chest drain showed reduced opacity at the right lower lobe. Chest radiograph (B) showed improving opacity of right lower lobe after first instillation of alteplase to upper chest drain. Chest radiograph before discharge (C) showed near resolution with area of non-expandable lung at the right apex Patient was treated for empyema with intravenous lung at the right apex (figure 3C). As he was tazobactam/piperacillin 4.5 gram twice daily; and asymptomatic, he was treated conservatively. He is intradialytic total parenteral nutrition was initiated. doing well currently. Despite regular flushing, the pleural catheter was not draining well. Another CT scan of thorax was Discussion performed, showed increasing size of right-sided pleural effusion which was loculated with pleural Chylothorax refers to accumulation of chyle in the thickening suggestive of early sign of empyema pleural space and is an infrequent, but potentially (Figure 2A and 2B). A new rocket seldinger chest life-threatening complication, with profound drain (12F) was inserted at the right lower thoracic respiratory, nutritional, and immunological area, however the drainage was still minimal consequences (5). It is characterized by elevated (<50cc/day). pleural fluid triglyceride level of more than 110 A multidisciplinary team consisting of mg/dL (1.24mmol/L), lack of cholesterol crystals pulmonologist, vascular surgeon, cardiothoracic and the presence of chylomicrons which is a gold surgeon, interventional radiologist, nephrologist, standard in diagnosing chyle pleural effusion (2). and dietician were involved in his care. Due to the The causes of chylothorax can be divided as underlying comorbidities and high risk of traumatic (iatrogenic and non-iatrogenic), non mortality with thoracotomy and decortication, we traumatic (tumour e.g lymphoma, malignant or decided to instill intra-pleural fibrinolytic therapy benign tumor), idiopathic (congenital) and other using alteplase for the multiloculated pleural cause chylothorax (2). effusion with. Another chest drain was inserted at As for our patient, CT lymphangiogram showed the upper right thoracic region. Sequential intra- cessation of lipiodol opacification of lymph nodes pleural alteplase was given to each chest drain. and lymphatic vessel at level T3 on the right and A total of 20mg intrapleural alteplase given at T5 on the left consistent with central venous right lower chest drain (5 mg 12 hourly) and 30mg thrombosis due to multiple jugular catheter alteplase (5 mg 12 hourly) at the upper right chest insertion in the past. The finding of central drain. venous thrombosis is a known cause of the Patient made a remarkable improvement even recurrent chylothorax. Due to multiple procedures after the first instillation of alteplase (figure 3A- involving pleura, he developed empyema. The B). A total of 2.5 L milkish-pink coloured effusion management of our patient was complex in which was drained collectively. After completing we had to deal with chylothorax and empyema as antibiotics, he was discharged well after 4 weeks two different entities. The empyema which was of admission. Dietary restriction (fat free diet and loculated; and him being high risk procedure for medium-chain triglycerides) were emphasized. He surgery makes the situation more complicated. did not develop any recurrence of chylothorax Treatment for chylothorax can be divided into since then and surgery was cancelled. Chest treatment of underlying disease, conservative or radiograph before he was discharged showed surgically approach (1-2). After thoracentesis, minimal effusion with an area of non-expandable patient can be treated conservatively with East J Med Volume:24, Number:3, July-September/2019 381 Faisal et al / Empyematous Multiloculated Chyolothorax adequate fluid and
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