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VIEW Open Access Muscle Spindle Function in Healthy and Diseased Muscle Stephan Kröger* and Bridgette Watkins
Kröger and Watkins Skeletal Muscle (2021) 11:3 https://doi.org/10.1186/s13395-020-00258-x REVIEW Open Access Muscle spindle function in healthy and diseased muscle Stephan Kröger* and Bridgette Watkins Abstract Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which is a requirement for motor control, for maintaining posture and for a stable gait. Many neuromuscular diseases affect muscle spindle function contributing, among others, to an unstable gait, frequent falls and ataxic behavior in the affected patients. Nevertheless, muscle spindles are usually ignored during examination and analysis of muscle function and when designing therapeutic strategies for neuromuscular diseases. This review summarizes the development and function of muscle spindles and the changes observed under pathological conditions, in particular in the various forms of muscular dystrophies. Keywords: Mechanotransduction, Sensory physiology, Proprioception, Neuromuscular diseases, Intrafusal fibers, Muscular dystrophy In its original sense, the term proprioception refers to development of head control and walking, an early im- sensory information arising in our own musculoskeletal pairment of fine motor skills, sensory ataxia with un- system itself [1–4]. Proprioceptive information informs steady gait, increased stride-to-stride variability in force us about the contractile state and movement of muscles, and step length, an inability to maintain balance with about muscle force, heaviness, stiffness, viscosity and ef- eyes closed (Romberg’s sign), a severely reduced ability fort and, thus, is required for any coordinated move- to identify the direction of joint movements, and an ab- ment, normal gait and for the maintenance of a stable sence of tendon reflexes [6–12]. -
Tissue Engineered Myelination and the Stretch Reflex Arc Sensory Circuit: Defined Medium Ormulation,F Interface Design and Microfabrication
University of Central Florida STARS Electronic Theses and Dissertations, 2004-2019 2009 Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium ormulation,F Interface Design And Microfabrication John Rumsey University of Central Florida Part of the Biology Commons Find similar works at: https://stars.library.ucf.edu/etd University of Central Florida Libraries http://library.ucf.edu This Doctoral Dissertation (Open Access) is brought to you for free and open access by STARS. It has been accepted for inclusion in Electronic Theses and Dissertations, 2004-2019 by an authorized administrator of STARS. For more information, please contact [email protected]. STARS Citation Rumsey, John, "Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication" (2009). Electronic Theses and Dissertations, 2004-2019. 3826. https://stars.library.ucf.edu/etd/3826 TISSUE ENGINEERED MYELINATION AND THE STRETCH REFLEX ARC SENSORY CIRCUIT: DEFINED MEDIUM FORMULATION, INTERFACE DESIGN AND MICROFABRICATION by JOHN WAYNE RUMSEY B.S. University of Florida, 2001 M.S. University of Central Florida, 2004 A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Burnett School of Biomedical Sciences in the College of Medicine at the University of Central Florida Orlando, Florida Fall Term 2009 Major Professor: James J. Hickman ABSTRACT The overall focus of this research project was to develop an in vitro tissue- engineered system that accurately reproduced the physiology of the sensory elements of the stretch reflex arc as well as engineer the myelination of neurons in the systems. In order to achieve this goal we hypothesized that myelinating culture systems, intrafusal muscle fibers and the sensory circuit of the stretch reflex arc could be bioengineered using serum-free medium formulations, growth substrate interface design and microfabrication technology. -
Back-To-Basics: the Intricacies of Muscle Contraction
Back-to- MIOTA Basics: The CONFERENCE OCTOBER 11, Intricacies 2019 CHERI RAMIREZ, MS, of Muscle OTRL Contraction OBJECTIVES: 1.Review the anatomical structure of a skeletal muscle. 2.Review and understand the process and relationship between skeletal muscle contraction with the vital components of the nervous system, endocrine system, and skeletal system. 3.Review the basic similarities and differences between skeletal muscle tissue, smooth muscle tissue, and cardiac muscle tissue. 4.Review the names, locations, origins, and insertions of the skeletal muscles found in the human body. 5.Apply the information learned to enhance clinical practice and understanding of the intricacies and complexity of the skeletal muscle system. 6.Apply the information learned to further educate clients on the importance of skeletal muscle movement, posture, and coordination in the process of rehabilitation, healing, and functional return. 1. Epithelial Four Basic Tissue Categories 2. Muscle 3. Nervous 4. Connective A. Loose Connective B. Bone C. Cartilage D. Blood Introduction There are 3 types of muscle tissue in the muscular system: . Skeletal muscle: Attached to bones of skeleton. Voluntary. Striated. Tubular shape. Cardiac muscle: Makes up most of the wall of the heart. Involuntary. Striated with intercalated discs. Branched shape. Smooth muscle: Found in walls of internal organs and walls of vascular system. Involuntary. Non-striated. Spindle shape. 4 Structure of a Skeletal Muscle Skeletal Muscles: Skeletal muscles are composed of: • Skeletal muscle tissue • Nervous tissue • Blood • Connective tissues 5 Connective Tissue Coverings Connective tissue coverings over skeletal muscles: .Fascia .Tendons .Aponeuroses 6 Fascia: Definition: Layers of dense connective tissue that separates muscle from adjacent muscles, by surrounding each muscle belly. -
A Device to Measure Tensile Forces in the Deep Fascia of the Human Abdominal Wall
A Device to Measure Tensile Forces in the Deep Fascia of the Human Abdominal Wall Sponsored by Dr. Raymond Dunn of the University of Massachusetts Medical School A Major Qualifying Report Submitted to the Faculty Of the WORCESTER POLYTECHNIC INSTITUTE In partial fulfillment of the requirements for the Degree of Bachelor of Science By Olivia Doane _______________________ Claudia Lee _______________________ Meredith Saucier _______________________ April 18, 2013 Advisor: Professor Kristen Billiar _______________________ Co-Advisor: Dr. Raymond Dunn _______________________ Table of Contents Table of Figures ............................................................................................................................. iv List of Tables ................................................................................................................................. vi Authorship Page ............................................................................................................................ vii Acknowledgements ...................................................................................................................... viii Abstract .......................................................................................................................................... ix Chapter 1: Introduction ................................................................................................................... 1 Chapter 2: Literature Review ......................................................................................................... -
Parts of the Body 1) Head – Caput, Capitus 2) Skull- Cranium Cephalic- Toward the Skull Caudal- Toward the Tail Rostral- Toward the Nose 3) Collum (Pl
BIO 3330 Advanced Human Cadaver Anatomy Instructor: Dr. Jeff Simpson Department of Biology Metropolitan State College of Denver 1 PARTS OF THE BODY 1) HEAD – CAPUT, CAPITUS 2) SKULL- CRANIUM CEPHALIC- TOWARD THE SKULL CAUDAL- TOWARD THE TAIL ROSTRAL- TOWARD THE NOSE 3) COLLUM (PL. COLLI), CERVIX 4) TRUNK- THORAX, CHEST 5) ABDOMEN- AREA BETWEEN THE DIAPHRAGM AND THE HIP BONES 6) PELVIS- AREA BETWEEN OS COXAS EXTREMITIES -UPPER 1) SHOULDER GIRDLE - SCAPULA, CLAVICLE 2) BRACHIUM - ARM 3) ANTEBRACHIUM -FOREARM 4) CUBITAL FOSSA 6) METACARPALS 7) PHALANGES 2 Lower Extremities Pelvis Os Coxae (2) Inominant Bones Sacrum Coccyx Terms of Position and Direction Anatomical Position Body Erect, head, eyes and toes facing forward. Limbs at side, palms facing forward Anterior-ventral Posterior-dorsal Superficial Deep Internal/external Vertical & horizontal- refer to the body in the standing position Lateral/ medial Superior/inferior Ipsilateral Contralateral Planes of the Body Median-cuts the body into left and right halves Sagittal- parallel to median Frontal (Coronal)- divides the body into front and back halves 3 Horizontal(transverse)- cuts the body into upper and lower portions Positions of the Body Proximal Distal Limbs Radial Ulnar Tibial Fibular Foot Dorsum Plantar Hallicus HAND Dorsum- back of hand Palmar (volar)- palm side Pollicus Index finger Middle finger Ring finger Pinky finger TERMS OF MOVEMENT 1) FLEXION: DECREASE ANGLE BETWEEN TWO BONES OF A JOINT 2) EXTENSION: INCREASE ANGLE BETWEEN TWO BONES OF A JOINT 3) ADDUCTION: TOWARDS MIDLINE -
Be Able to Describe a Stretch Reflex
be able to describe a stretch reflex .(1) (2) Define muscle tone (3) be able to explain what is muscle tone (4) describe the structure , innervations and function of the muscle spindle . (5) explain what is meant by static and dynamic stretch reflex . (6) describe the spinal and supraspinal regulation of the stretch reflex . (7) describe the inverse stretch reflex and its function Stretch reflex: Whenever a muscle is stretched suddenly, excitation of the muscle spindle causes reflex contraction of the large muscle fiber (See the pictures). It is deep and monosynaptic reflex. Stretch response is produced by co-activation of alpha & gamma motor neurons. But it is maintained mainly by the tonic ( continuous) discharge of Gamma Efferent neurons. Muscle spindle: It is a sensory receptors which are distributed throughout the muscle and it sends information to nervous system about muscle length or rate of change in muscle length. - Each spindle is built around 3-12 intrafusal muscle fibers. - Muscle spindles are parallel to extrafusal muscle fibers and they are attached to them or to the tendon. Types of Intrafusal fibers Each intrafusal fiber consists of: (1) Central non-contractile area (receptor 2) Nuclear chain fibers: area). thinner and shorter 1) Nuclear bag fibers: than nuclear bag fibers (2) Peripheral contractile area. contain many nuclei in , and have one line of a dilated central area ( “ nuclei spread in a chain bag ” ) . Typically there along the receptor area are 2 nuclear bag fibers . There are 4 – 9 per spindle . nuclear chain -
Fascial Contraction Fascia Can Be Divided Into Two General Categories: Sub Cutaneous Fascia and Deep Fascia, Also Known As Muscu Lar Fascia
by joe muscolino body mechanics Bodywork and movement therapy can help with contracted fascial tissue. fascial contraction Fascia can be divided into two general categories: sub- examples of deep fibrous fascia, as cutaneous fascia and deep fascia, also known as muscu- are ligaments and intermuscular lar fascia. Subcutaneous fascia, as the name implies, is septa. The loosely packed struc- located immediately deep to the skin. It is largely com- ture of subcutaneous fascia allows www.amtamassage.org/mtj posed of adipose (fat) cells, giving it its gel-like consis- for a healthy blood supply, giving it tency. Collagen fibers and fibroblast cells are embedded strong reparative properties when within this mix of adipose cells. Deep fascia is located injured. Alternatively, the dense ar- deeper in the body and is primarily comprised of dense- rangement of fibrous fascia does not ly packed collagen fibers, accounting for its description allow adequate room for blood ves- as fibrous fascia. Fibroblasts are located between these sels; therefore, fibrous fascia has a collagen fibers (Figure 1). poor blood supply and does not heal Endomysium, perimysium and epimysium, which well when injured. In addition to 145 create the tendons and aponeuroses of muscles, are collagen fibers and fibroblasts, both body mechanics Recent research suggests that fascia does and stretched, having the ability to transfer these pull- ing forces to other tissues. For example, when a muscle not function only in a belly contracts and pulls upon its tendons, these fibrous passive tensile manner, tissue tendons transfer that pulling force to the bony at- tachments of the muscle. -
Pectoral Region and Axilla Doctors Notes Notes/Extra Explanation Editing File Objectives
Color Code Important Pectoral Region and Axilla Doctors Notes Notes/Extra explanation Editing File Objectives By the end of the lecture the students should be able to : Identify and describe the muscles of the pectoral region. I. Pectoralis major. II. Pectoralis minor. III. Subclavius. IV. Serratus anterior. Describe and demonstrate the boundaries and contents of the axilla. Describe the formation of the brachial plexus and its branches. The movements of the upper limb Note: differentiate between the different regions Flexion & extension of Flexion & extension of Flexion & extension of wrist = hand elbow = forearm shoulder = arm = humerus I. Pectoralis Major Origin 2 heads Clavicular head: From Medial ½ of the front of the clavicle. Sternocostal head: From; Sternum. Upper 6 costal cartilages. Aponeurosis of the external oblique muscle. Insertion Lateral lip of bicipital groove (humerus)* Costal cartilage (hyaline Nerve Supply Medial & lateral pectoral nerves. cartilage that connects the ribs to the sternum) Action Adduction and medial rotation of the arm. Recall what we took in foundation: Only the clavicular head helps in flexion of arm Muscles are attached to bones / (shoulder). ligaments / cartilage by 1) tendons * 3 muscles are attached at the bicipital groove: 2) aponeurosis Latissimus dorsi, pectoral major, teres major 3) raphe Extra Extra picture for understanding II. Pectoralis Minor Origin From 3rd ,4th, & 5th ribs close to their costal cartilages. Insertion Coracoid process (scapula)* 3 Nerve Supply Medial pectoral nerve. 4 Action 1. Depression of the shoulder. 5 2. Draw the ribs upward and outwards during deep inspiration. *Don’t confuse the coracoid process on the scapula with the coronoid process on the ulna Extra III. -
A Comprehensive Review of Anatomy and Regional Anesthesia Techniques of Clavicle Surgeries
vv ISSN: 2641-3116 DOI: https://dx.doi.org/10.17352/ojor CLINICAL GROUP Received: 31 March, 2021 Research Article Accepted: 07 April, 2021 Published: 10 April, 2021 *Corresponding author: Dr. Kartik Sonawane, Uncovering secrets of the Junior Consultant, Department of Anesthesiol- ogy, Ganga Medical Centre & Hospitals, Pvt. Ltd. Coimbatore, Tamil Nadu, India, E-mail: beauty bone: A comprehensive Keywords: Clavicle fractures; Floating shoulder sur- gery; Clavicle surgery; Clavicle anesthesia; Procedure review of anatomy and specific anesthesia; Clavicular block regional anesthesia techniques https://www.peertechzpublications.com of clavicle surgeries Kartik Sonawane1*, Hrudini Dixit2, J.Balavenkatasubramanian3 and Palanichamy Gurumoorthi4 1Junior Consultant, Department of Anesthesiology, Ganga Medical Centre & Hospitals, Pvt. Ltd., Coimbatore, Tamil Nadu, India 2Fellow in Regional Anesthesia, Department of Anesthesiology, Ganga Medical Centre & Hospitals, Pvt. Ltd., Coimbatore, Tamil Nadu, India 3Senior Consultant, Department of Anesthesiology, Ganga Medical Centre & Hospitals, Pvt. Ltd., Coimbatore, Tamil Nadu, India 4Consultant, Department of Anesthesiology, Ganga Medical Centre & Hospitals, Pvt. Ltd., Coimbatore, Tamil Nadu, India Abstract The clavicle is the most frequently fractured bone in humans. General anesthesia with or without Regional Anesthesia (RA) is most frequently used for clavicle surgeries due to its complex innervation. Many RA techniques, alone or in combination, have been used for clavicle surgeries. These include interscalene block, cervical plexus (superficial and deep) blocks, SCUT (supraclavicular nerve + selective upper trunk) block, and pectoral nerve blocks (PEC I and PEC II). The clavipectoral fascial plane block is also a safe and simple option and replaces most other RA techniques due to its lack of side effects like phrenic nerve palsy or motor block of the upper limb. -
Multi-Scale Modelling of the Neuromuscular System -- Coupling
Received: 21 January 2019 Revised: 13 May 2019 Accepted: 14 May 2019 DOI: 10.1002/wsbm.1457 ADVANCED REVIEW Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics Oliver Röhrle1,2 | Utku S¸. Yavuz1,3 | Thomas Klotz1,2 | Francesco Negro4 | Thomas Heidlauf5 1Institute for Modelling and Simulation of Biomechanical Systems, University of Abstract Stuttgart, Stuttgart, Germany Mathematical models and computer simulations have the great potential to substan- 2Stuttgart Center for Simulation Sciences tially increase our understanding of the biophysical behavior of the neuromuscular (SC SimTech), University of Stuttgart, system. This, however, requires detailed multiscale, and multiphysics models. Stuttgart, Germany Once validated, such models allow systematic in silico investigations that are not 3Biomedical Signals and Systems, Universiteit Twente, Enschede, necessarily feasible within experiments and, therefore, have the ability to provide The Netherlands valuable insights into the complex interrelations within the healthy system and for 4 Department of Clinical and Experimental pathological conditions. Most of the existing models focus on individual parts of Sciences, Universià degli Studi di Brescia, Brescia, Italy the neuromuscular system and do not consider the neuromuscular system as an 5EPS5 – Simulation and System Analysis, integrated physiological system. Hence, the aim of this advanced review is to facili- Hofer pdc GmbH, Stuttgart, Germany tate the prospective development of detailed biophysical models of the entire neu- romuscular system. For this purpose, this review is subdivided into three parts. The Correspondence Oliver Röhrle, Institute for Modelling and first part introduces the key anatomical and physiological aspects of the healthy Simulation of Biomechanical Systems, neuromuscular system necessary for modeling the neuromuscular system. -
A Detailed Review on the Clinical Anatomy of the Pectoralis Major Muscle
SMGr up Review Article SM Journal of A Detailed Review on the Clinical Clinical Anatomy Anatomy of the Pectoralis Major Muscle Alexey Larionov, Peter Yotovski and Luis Filgueira* University of Fribourg, Faculty of Science and Medicine, Switzerland Article Information Abstract Received date: Aug 25, 2018 The pectoralis major is a muscle of the upper limb girdle. This muscle has a unique morphological Accepted date: Sep 07, 2018 architectonic and a high rate of clinical applications. However, there is lack of data regarding the morphological and functional interactions of the pectoralis major with other muscle and fascial compartments. According to the Published date: Sep 12, 2018 applied knowledge, the “Humero-pectoral” morpho-functional concept has been postulated. The purpose of this review was the dissectible investigation of the muscle anatomy and literature review of surgical applications. *Corresponding author Luis Filgueira, University of Fribourg, General Anatomy Faculty of Science and Medicine,1 Albert Gockel, CH-1700 Fribourg, Switzerland, The pectoralis major is a large, flat muscle of the pectoral girdle of the upper limb. It has a fan- Tel: +41 26 300 8441; shaped appearance with three heads or portions: the clavicular, the sternocostal and the abdominal Email: [email protected] head. Distributed under Creative Commons The clavicular head originates from the medial two-thirds of the clavicle (collar bone). The muscle fibers of the clavicular head have a broad origin on the caudal-anterior and caudal-posterior surface CC-BY 4.0 of the clavicle covering approximately half to two-thirds of that surface and converting toward the humerus, resulting in a triangular shape [1]. -
Biology 218 – Human Anatomy RIDDELL
Biology 218 – Human Anatomy RIDDELL Chapter 10 Adapted form Tortora 10th ed. LECTURE OUTLINE A. Introduction (p. 265) 1. Bones provide leverage and form the framework of the body, but motion results from alternating contraction (shortening) and relaxation of muscles. 2. Muscle tissue also stabilizes the body’s position, regulates organ volume, generates heat, and propels fluids and food through various body systems. 3. The study of muscles is called myology. B. Overview of Muscle Tissue (p. 266) 1. There are three types of muscle tissue (see Table 10.2): i. Skeletal muscle tissue a. moves bones (and, in some cases, skin and other soft tissues) b. striated c. voluntary ii. Cardiac muscle tissue a. forms most of the wall of the heart b. striated c. involuntary d. some cells have autorhythmicity iii. Smooth muscle tissue a. located in the walls of hollow internal structures (and arrector pili muscles) b. nonstriated, i.e., smooth c. involuntary d. some cells have autorhythmicity 2. Muscle tissue has four major functions: i. producing body movements ii. stabilizing body positions iii. storing and moving substances within the body iv. producing heat 3. Muscle tissue has four major characteristics that enable it to perform its functions: i. Electrical excitability is the ability to respond to certain stimuli by producing electrical signals called action potentials (impulses) ii. Contractility is the ability to shorten, thus developing tension (force of contraction) a. in an isometric contraction, a muscle develops tension but does not shorten b. in an isotonic contraction, tension remains relatively constant while the muscle shortens iii.