Flavonoids with Potential Anti-Inflammatory Activity: in Vitro Structure/Activity Studies of Their Effects in Pro- Inflammatory Signalling Systems
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Clinical Study Is Nonmicronized Diosmin 600Mg As Effective As
Hindawi International Journal of Vascular Medicine Volume 2020, Article ID 4237204, 9 pages https://doi.org/10.1155/2020/4237204 Clinical Study Is Nonmicronized Diosmin 600mg as Effective as Micronized Diosmin 900mg plus Hesperidin 100mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study Marcio Steinbruch,1 Carlos Nunes,2 Romualdo Gama,3 Renato Kaufman,4 Gustavo Gama,5 Mendel Suchmacher Neto,6 Rafael Nigri,7 Natasha Cytrynbaum,8 Lisa Brauer Oliveira,9 Isabelle Bertaina,10 François Verrière,10 and Mauro Geller 3,6,9 1Hospital Albert Einstein (São Paulo-Brasil), R. Mauricio F Klabin 357/17, Vila Mariana, SP, Brazil 04120-020 2Instituto de Pós-Graduação Médica Carlos Chagas-Fundação Educacional Serra dos Órgãos-UNIFESO (Rio de Janeiro/Teresópolis- Brasil), Av. Alberto Torres 111, Teresópolis, RJ, Brazil 25964-004 3Fundação Educacional Serra dos Órgãos-UNIFESO (Teresópolis-Brasil), Av. Alberto Torres 111, Teresópolis, RJ, Brazil 25964-004 4Faculdade de Ciências Médicas, Universidade Estadual do Rio de Janeiro (UERJ) (Rio de Janeiro-Brazil), Av. N. Sra. De Copacapana, 664/206, Rio de Janeiro, RJ, Brazil 22050-903 5Fundação Educacional Serra dos Órgãos-UNIFESO (Teresópolis-Brasil), Rua Prefeito Sebastião Teixeira 400/504-1, Rio de Janeiro, RJ, Brazil 25953-200 6Instituto de Pós-Graduação Médica Carlos Chagas (Rio de Janeiro-Brazil), R. General Canabarro 68/902, Rio de Janeiro, RJ, Brazil 20271-200 7Department of Medicine, Rutgers New Jersey Medical School-USA, 185 S Orange Ave., Newark, NJ 07103, USA 8Hospital Universitário Pedro Ernesto, Universidade Estadual do Rio de Janeiro (UERJ) (Rio de Janeiro-Brazil), R. Hilário de Gouveia, 87/801, Rio de Janeiro, RJ, Brazil 22040-020 9Universidade Federal do Rio de Janeiro (UFRJ) (Rio de Janeiro-Brazil), Av. -
Candidate Gene Identification from the Wheat QTL-2DL for Resistance Against Fusarium Head Blight Based on Metabolo-Genomics Approach
Candidate gene identification from the wheat QTL-2DL for resistance against Fusarium head blight based on metabolo-genomics approach Udaykumar Kage Department of Plant Science McGill University, Montreal, Canada August 2016 A thesis submitted to the McGill University in partial fulfillment of the requirements of the degree of Doctor of Philosophy ©Udaykumar Kage (2016) i Dedicated to my beloved parents ii TABLE OF CONTENTS TABLE OF CONTENTS………………………………………………………………………...iii LIST OF TABLES……………………………………………………………………………...viii LIST OF FIGURES………………………………………………………………………………ix LIST OF APPENDICES…………………………………………………………………………xv LIST OF ABBREVIATIONS…………………………………………………………………...xvi ABSTRACT…………………………………………………………………………………...xviii ACKNOWLEDGEMENT……………………………………………………………………...xxi PREFACE AND CONTRIBUTION OF THE AUTHORS……………………………………..01 PREFACE……………………………………………………………………………………......01 CONTRIBUTION OF THE AUTHORS………………………………………………………...02 CHAPTER I: GENERAL INTRODUCTION…………………………………………………...03 GENERAL HYPOTHESIS……………………………………………………………………...07 GENERAL OBJECTIVES……………………………………………………………………....07 CHAPTER II: REVIEW OF THE LITERATURE……………………………………………...08 2.1 Fusarium head blight of wheat at a glance…………………………………………………...08 2.1.1 Fusarium head blight epidemiology and impact on wheat production…………………08 2.1.2 FHB management practices ……………………………………………………….……10 2.1.3 FHB management through breeding for disease resistance…………………………….11 2.1.3.1 Types of Fusarium head blight resistance………………………………………….12 2.1.3.2 Molecular markers and QTL for FHB resistance……………………………….…13 -
Small Molecule–Mediated Reprogramming of the Epithelial–Mesenchymal Transition
bioRxiv preprint doi: https://doi.org/10.1101/106591; this version posted February 16, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Small molecule–mediated reprogramming of the epithelial–mesenchymal transition prevents fibrosis Running title: Reversion of fibrosis by chromones Han-Soo Kim,1,2* Jun-Hwan Kim,1,3* Ji Yong Lee,2 Young-Min Yoon,3 Ik-Hwan Kim,4 Ho- Sup Yoon5 and Byung-Soo Youn3# 1Institute for BioMedical Convergence, Catholic Kwandong University-International St. Mary’s Hospital, Incheon 22711, Republic of Korea , 2Department of Biomedical Sciences, Catholic Kwandong University College of Medicine, Gangneung-si, Gangwon-do 25601, Republic of Korea. 3#705 Ace High-end Tower 9th 233,Gasandigital-1-ro, Geumcheon- gu, Seoul, 08501, Republic of Korea, 4Department of Biotechnology, Korea University. Seoul 02841and 5Department of Genetic Engineering, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea and 5School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore *These contributes equally to this work. #Corresponding author: Byung-Soo Youn, PhD, OsteoNeuroGen, Inc. Ace High-end Tower 9th 233, Gasandigital-1-ro, Geumcheon-gu, Seoul, 08501, Republic of Korea Email: [email protected], Tel) 822- 6267 2737 Fax) 822-6267-2740 1 bioRxiv preprint doi: https://doi.org/10.1101/106591; this version posted February 16, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. -
The Benefits of Flavonoids in Diabetic Retinopathy
nutrients Review The Benefits of Flavonoids in Diabetic Retinopathy 1, 1, 2,3,4,5 1,2,3,4, Ana L. Matos y, Diogo F. Bruno y, António F. Ambrósio and Paulo F. Santos * 1 Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal; [email protected] (A.L.M.); [email protected] (D.F.B.) 2 Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal; [email protected] 3 Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal 4 Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal 5 Association for Innovation and Biomedical Research on Light and Image (AIBILI), 3000-548 Coimbra, Portugal * Correspondence: [email protected]; Tel.: +351-239-240-762 These authors contributed equally to the work. y Received: 10 September 2020; Accepted: 13 October 2020; Published: 16 October 2020 Abstract: Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading cause of legal blindness among adults of working age in developed countries. After 20 years of diabetes, almost all patients suffering from type I diabetes mellitus and about 60% of type II diabetics have DR. Several studies have tried to identify drugs and therapies to treat DR though little attention has been given to flavonoids, one type of polyphenols, which can be found in high levels mainly in fruits and vegetables, but also in other foods such as grains, cocoa, green tea or even in red wine. -
Astragalin: a Bioactive Phytochemical with Potential Therapeutic Activities
Hindawi Advances in Pharmacological Sciences Volume 2018, Article ID 9794625, 15 pages https://doi.org/10.1155/2018/9794625 Review Article Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities Ammara Riaz,1 Azhar Rasul ,1 Ghulam Hussain,2 Muhammad Kashif Zahoor ,1 Farhat Jabeen,1 Zinayyera Subhani,3 Tahira Younis,1 Muhammad Ali,1 Iqra Sarfraz,1 and Zeliha Selamoglu4 1Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan 2Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan 3Department of Biochemistry, University of Agriculture, Faisalabad 38000, Pakistan 4Department of Medical Biology, Faculty of Medicine, Nigde O¨ mer Halisdemir University, Nigde 51240, Turkey Correspondence should be addressed to Azhar Rasul; [email protected] Received 8 January 2018; Revised 5 April 2018; Accepted 12 April 2018; Published 2 May 2018 Academic Editor: Paola Patrignani Copyright © 2018 Ammara Riaz et al. %is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. %is review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional -
Flavonoids: an Overview
Vidya V. Gawande et al. / Journal of Pharmacy Research 2012,5(11),5099-5101 Review Article Available online through ISSN: 0974-6943 http://jprsolutions.info Flavonoids: An Overview Vidya V. Gawande* and S. V. Kalikar Department of Pharmacy,Government Polytechnic, Gadgenagar, VMV Road, Amravati(MS), India 444603 Received on:14-07-2012; Revised on: 19-08-2012; Accepted on:23-09-2012 ABSTRACT Flavonoids belong to a group of polyphenolic compounds, which are classified as flavonols, flavonones, flavones, flavan-3-ols and isoflavones, anthocynidins according to the positions of the substitutes present on the parent molecule. Flavonoids occur as aglycones, glycosides and methylated derivatives in plants. Flavonoids occur naturally in fruit, vegetables, and beverages such as tea and wine and over 4000 structurally unique flavonoids have been identified in plant sources. These are primarily recognized as the pigments responsible for the many shades of yellow, orange, and red in flowers, fruits, and leaves. The major actions of flavonoids are those against cardiovascular diseases, ulcers, viruses, inflammation, osteoporosis, diarrhea and arthritis. Flavonoids have also been known to possess biochemical effects, which inhibit a number of enzymes such as aldosereductase, xanthine oxidase, phosphodiesterase, Ca+2-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormones. Flavonoids like quercetin are shown to produce anti-inflammatory effect. The flavonoids in tea are found to be responsible for the prevention of osteoporosis. Quercetin is now found to show inhibiting effects against herpes simplex virus. Antidiarrheal effect is found to be shown by the flavonoids present in cocoa. -
Supplementary Materials Evodiamine Inhibits Both Stem Cell and Non-Stem
Supplementary materials Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70 Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee - 1 - Table S1. Short tandem repeat (STR) DNA profiles for human cancer cell lines used in this study. MDA-MB-231 Marker H1299 H460 A549 HCT116 (MDA231) Amelogenin XX XY XY XX XX D8S1179 10, 13 12 13, 14 10, 14, 15 13 D21S11 32.2 30 29 29, 30 30, 33.2 D7S820 10 9, 12 8, 11 11, 12 8 CSF1PO 12 11, 12 10, 12 7, 10 12, 13 D3S1358 17 15, 18 16 12, 16, 17 16 TH01 6, 9.3 9.3 8, 9.3 8, 9 7, 9.3 D13S317 12 13 11 10, 12 13 D16S539 12, 13 9 11, 12 11, 13 12 D2S1338 23, 24 17, 25 24 16 21 D19S433 14 14 13 11, 12 11, 14 vWA 16, 18 17 14 17, 22 15 TPOX 8 8 8, 11 8, 9 8, 9 D18S51 16 13, 15 14, 17 15, 17 11, 16 D5S818 11 9, 10 11 10, 11 12 FGA 20 21, 23 23 18, 23 22, 23 - 2 - Table S2. Antibodies used in this study. Catalogue Target Vendor Clone Dilution ratio Application1) Number 1:1000 (WB) ADI-SPA- 1:50 (IHC) HSP70 Enzo C92F3A-5 WB, IHC, IF, IP 810-F 1:50 (IF) 1 :1000 (IP) ADI-SPA- HSP90 Enzo 9D2 1:1000 WB 840-F 1:1000 (WB) Oct4 Abcam ab19857 WB, IF 1:100 (IF) Nanog Cell Signaling 4903S D73G4 1:1000 WB Sox2 Abcam ab97959 1:1000 WB ADI-SRA- Hop Enzo DS14F5 1:1000 WB 1500-F HIF-1α BD 610958 54/HIF-1α 1:1000 WB pAkt (S473) Cell Signaling 4060S D9E 1:1000 WB Akt Cell Signaling 9272S 1:1000 WB pMEK Cell Signaling 9121S 1:1000 WB (S217/221) MEK Cell Signaling 9122S 1:1000 -
Graphical Abstract CG 18-1-MS
Send Orders for Reprints to [email protected] 3 Current Genomics, 2017, 18, 3-26 REVIEW ARTICLE ISSN: 1389-2029 eISSN: 1875-5488 Impact Factor: 2.43 Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids BENTHAM SCIENCE Katrin Sak* and Hele Everaus Department of Hematology and Oncology, University of Tartu, Tartu, Estonia Abstract: Despite the extensive work on pathological mechanisms and some recent advances in the treatment of different hematological malignancies, leukemia continues to present a significant challenge being frequently considered as incurable disease. Therefore, the development of novel therapeutic agents with high efficacy and low toxicity is urgently needed to improve the overall survival rate of pa- A R T I C L E H I S T O R Y tients. In this comprehensive review article, the current knowledge about the anticancer activities of Received: May 11, 2015 flavonoids as plant secondary polyphenolic metabolites in the most commonly used human established Revised: November 20, 2015 Accepted: November 27, 2015 leukemia cell lines (HL-60, NB4, KG1a, U937, THP-1, K562, Jurkat, CCRF- CEM, MOLT-3, and MOLT-4) is compiled, revealing clear anti-proliferative, pro-apoptotic, cell cycle arresting, and differ- DOI: 10.2174/138920291766616080316 entiation inducing effects for certain compounds. Considering the low toxicity of these substances in 5447 normal blood cells, the presented data show a great potential of flavonoids to be developed into novel anti-leukemia agents applicable also in the malignant cells resistant to the current conventional che- motherapeutic drugs. Keywords: Antiproliferation, Apoptosis, Cell cycle arrest, Cytotoxicity, Differentiation, Flavonoids, Leukemia, Human cell lines. -
Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant
molecules Review Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review Javad Mottaghipisheh 1,* and Marcello Iriti 2,* 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary 2 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy * Correspondence: [email protected] (J.M.); [email protected] (M.I.); Tel.: +36-60702756066 (J.M.); +39-0250316766 (M.I.) Academic Editor: Francesco Cacciola Received: 20 August 2020; Accepted: 8 September 2020; Published: 10 September 2020 Abstract: Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated from the Asparagaceae and Lauraceae families, respectively, while the Asteraceae was the richest in flavones possessing 22 derivatives. Six flavones, four flavonols, three homoisoflavonoids, one flavanone, a flavanol, and an isoflavanol have been isolated as the new secondary metabolites. This technique has been able to isolate quercetin from 19 plant species, along with its 31 derivatives. Pure methanol and in combination with water, chloroform, and dichloromethane have generally been used as eluents. This comprehensive review provides significant information regarding to remarkably use of SLH in isolation and purification of flavonoids from all the plant families; thus, it might be considered an appreciable guideline for further phytochemical investigation of these compounds. -
Isorhamnetin a Review of Pharmacological Effects
LJMU Research Online Gong, G, Guan, Y-Y, Zhang, Z-L, Rahman, K, Wang, S-J, Zhou, S, Luan, X and Zhang, H Isorhamnetin: A review of pharmacological effects. http://researchonline.ljmu.ac.uk/id/eprint/13470/ Article Citation (please note it is advisable to refer to the publisher’s version if you intend to cite from this work) Gong, G, Guan, Y-Y, Zhang, Z-L, Rahman, K, Wang, S-J, Zhou, S, Luan, X and Zhang, H (2020) Isorhamnetin: A review of pharmacological effects. Biomedicine & Pharmacotherapy, 128. ISSN 0753-3322 LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain. The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. For more information please contact [email protected] http://researchonline.ljmu.ac.uk/ Biomedicine & Pharmacotherapy 128 (2020) 110301 Contents lists available at ScienceDirect Biomedicine & Pharmacotherapy journal homepage: www.elsevier.com/locate/biopha Review Isorhamnetin: A review -
Mechanisms of Toxic Action of the Flavonoid Quercetin and Its Phase II Metabolites
Mechanisms of toxic action of the flavonoid quercetin and its phase II metabolites Hester van der Woude Promotor: Prof. Dr. Ir. I.M.C.M. Rietjens Hoogleraar in de Toxicologie Wageningen Universiteit Co-promotor: Dr. G.M. Alink Universitair Hoofddocent, Sectie Toxicologie Wageningen Universiteit. Promotiecommissie: Prof. Dr. A. Bast Universiteit Maastricht Dr. Ir. P.C.H. Hollman RIKILT Instituut voor Voedselveiligheid, Wageningen Prof. Dr. Ir. F.J. Kok Wageningen Universiteit Prof. Dr. T. Walle Medical University of South Carolina, Charleston, SC, USA Dit onderzoek is uitgevoerd binnen de onderzoekschool VLAG Mechanisms of toxic action of the flavonoid quercetin and its phase II metabolites Hester van der Woude Proefschrift ter verkrijging van de graad van doctor op gezag van de rector magnificus van Wageningen Universiteit, Prof. Dr. M.J. Kropff, in het openbaar te verdedigen op vrijdag 7 april 2006 des namiddags te half twee in de Aula Title Mechanisms of toxic action of the flavonoid quercetin and its phase II metabolites Author Hester van der Woude Thesis Wageningen University, Wageningen, the Netherlands (2006) with abstract, with references, with summary in Dutch. ISBN 90-8504-349-2 Abstract During and after absorption in the intestine, quercetin is extensively metabolised by the phase II biotransformation system. Because the biological activity of flavonoids is dependent on the number and position of free hydroxyl groups, a first objective of this thesis was to investigate the consequences of phase II metabolism of quercetin for its biological activity. For this purpose, a set of analysis methods comprising HPLC-DAD, LC-MS and 1H NMR proved to be a useful tool in the identification of the phase II metabolite pattern of quercetin in various biological systems. -
And East Siberian Rhododendron (Rh. Adamsii) Using Supercritical CO2-Extraction and HPLC-ESI-MS/MS Spectrometry
molecules Article Comparative Analysis of Far East Sikhotinsky Rhododendron (Rh. sichotense) and East Siberian Rhododendron (Rh. adamsii) Using Supercritical CO2-Extraction and HPLC-ESI-MS/MS Spectrometry Mayya Razgonova 1,2,* , Alexander Zakharenko 1,2 , Sezai Ercisli 3 , Vasily Grudev 4 and Kirill Golokhvast 1,2,5 1 N.I. Vavilov All-Russian Institute of Plant Genetic Resources, 190000 Saint-Petersburg, Russia; [email protected] (A.Z.); [email protected] (K.G.) 2 SEC Nanotechnology, Far Eastern Federal University, 690950 Vladivostok, Russia 3 Agricultural Faculty, Department of Horticulture, Ataturk University, 25240 Erzurum, Turkey; [email protected] 4 Far Eastern Investment and Export Agency, 123112 Moscow, Russia; [email protected] 5 Pacific Geographical Institute, Far Eastern Branch of the Russian Academy of Sciences, 690041 Vladivostok, Russia * Correspondence: [email protected] Academic Editors: Seung Hwan Yang and Satyajit Sarker Received: 29 June 2020; Accepted: 12 August 2020; Published: 19 August 2020 Abstract: Rhododendron sichotense Pojark. and Rhododendron adamsii Rheder have been actively used in ethnomedicine in Mongolia, China and Buryatia (Russia) for centuries, as an antioxidant, immunomodulating, anti-inflammatory, vitality-restoring agent. These plants contain various phenolic compounds and fatty acids with valuable biological activity. Among green and selective extraction methods, supercritical carbon dioxide (SC-CO2) extraction has been shown to be the method of choice for the recovery of these naturally occurring compounds. Operative parameters and working conditions have been optimized by experimenting with different pressures (300–400 bar), temperatures (50–60 ◦C) and CO2 flow rates (50 mL/min) with 1% ethanol as co-solvent. The extraction time varied from 60 to 70 min.