DOCSLIB.ORG

The Atomic Energy Commission

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The Atomic Energy Commission L ARGONNE CANCER RESEARCH HOS 95,O EA'ST FIFTY-NINTH STREET CHICAGO 37 * -ILLINOIS A, L . Semiannual Report to THE ATOMIC ENERGY COMMISSION ' MARCH 1961' LEON a JACOBSON; AD. Editor iop@%TED BY WE UM~OF CMICAGICS '. UNDER CONTRACT' AT-(7 1-l)-6C)I .' ' LC I>-. .- .s " - L', - -- - - I _.- - -- --VA DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency Thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. LEGAL NOT-ICE' ~n~wSe$~~stl-db.tof~~ant@-dw&.~d~thb~nkeci &aa~;nw&Gd~noranppersonsd"ulgonWofUteCd: ~easny~Warwpmte~~~orh~liad~~~ttotha~-. corn- or Muhesg of tb Somutiq~~cmt&ied in W W~B$ QP hfi,the ~ae6f any fefomnatim, mtue~method, or prooees disclosed in thie npwt msg not privately B, ~manyIi&~d~hhaseob,oafm~d~hhose ofwsaS-Oa, appwtus, maEhos, afpmw~Wdin thkeport. L used in tbe &om. 6%4n belurli of the c'&atr'* iqcladea any emplopc~ urr ~~of the Get011ta thsartaaz tbsa edempl@we or centmetor ppmm, Ian& or Mb- or provida aceaa~& aq;p Wormphi pmnsnt to his emplopwit or contra& *the- . .on. ACRH-15 ARGONNE CANCER RESEARCH HOSPITAL 950 EAST FIFTY-N1NT.H STREET CHICAGO 37 ILLINOIS Semiannual Report to THE ATOMIC ENERGY COMMISSION MARCH 1961 LEON 0. .JACOBSON, M.D. Editor MARGOT DOYLE, Ph.D. Associate Editor OPERATED BY THE UNIVERSITY OF CHICAGO UNDER CONTRACT AT-(1 1-1)-69 TABLE OF CONTENTS Comparison of the effects of isologous, homologous, and heterologous hematopoietic . tissues on post-irradiation survival. L. 0. Jaeoboon and E. L. Simmnns ................................ Studles UII Llit survival of transfused blnnrl in rats. J. S. Thompson, C. W. Gurney, A. Hanel, E. Ford, and D. Rofstra ........... Studies on erythropoiesis XVII. Some quantitative aspects of the erythropoietic re- sponse to erythropoietin. C. W. Gurney, N. Wackman, and E. Filmanowicz ....................... Inhibition of erythropcsiesis by estrogens. P. P. Dukes-and E. Goldwasser .................................. Studies on tryptophan metabolism. I. Urinary tryptophan metabolites in hypoplastic anemias and other hematologic disorders. H. S.. Marver. .............................................. Effect of daily exposure to 15 r Y -radiation on susceptibility of mice to experimental infection. C. W. Hammond, S. K. Anderle, and C. P. Miller ...................... Attempts to increase resistance of mice to bacterial infection by prolonged low dose Y -irradiation. C. W. Hammond, S. K. Anderle, and C. P. Miller ...................... Restoration of serum bactericidal activity and prevention of its loss in x-irradiated mice. L. Kornfeld and C. P. Miller .................................... Immunohistochemical study of Ehrlich ascites tumor. F. W. Fitch ................................................ Comparison of effects of 1l3'-induced hypothyroidism axid L-triiodothyronine on irra- diated hair roots in mice. M. L. Griem, J. A. Stein, R. P. Reinertson, R. Reinertson, and B. R. Brown.. ... Modification of radiation responses of tissue by colchicine: effects on mouse hair roots. M. L. Griem, F. D. Malkinson, and P. H. Morse ....................... Production and use of Iodine -125. P. V. Harper, W. D. Siemens, K. A. Lathrop, and H. Endlich ............... The localization of octoiodofluorescein-1l3' in human brain tumors. E. C. Tocus, G. T. Okita, J. P. Evans, and S. Mullan .................... A theoretical evaluation of brain scaru~ingsystems. R.N.Beck ................................................ The thick target yield and excitation function for the reaction ~h'O~(~n)~d103., P. V. Harper, K. Lathrop, and J. L. Need. ........................... Brain cholesterol: incorporation .of select carbon- 14 and tritium precursors into brain. J. J. Kabara and G. T. Okita ............... ; .................... Net synthesis of RNA with a microbial enzyme requiring DNA and four ribonucleoside triphosphates S. B. Weiss and T. Nakamoto .......................... '; '......... 32 A new synthesis of (P )uridine 5' -phosphate. D. B. Straus and E. Goldwasser ................................ 139 Metabolism of 17 a-hydronyprogesterone-4-~14-17- a -capoate by homogenates of rat liver and human placenta. M. Wiener, G. I. Lupu, and E. J. Plotz. ............................ 14 1 Staff Publications. .............................................. 148 COMPARISON OF THE EFFECTS OF ISOLOGOUS, HOMOLOGOUS, AND HETEROLOGOU~TOPOIETIC TISSUES r==-* o~-&D&gg&!bgg$$L*T BY L. 0. Jacobson and E. L. Simmons The dream of replacing injured or diseased members of the body by a transplant of healthy tissue of human or other animal origin is of some antiquity. One of the earliest authenticated reports of such an attempt dates from 1682, and is described by ~ibson.' History does not tell US how successful this substitution of a dog's cranium for part of a human skull may have been considered, since the Church disapproved of the operation, and in consequence the offending bone was removed. In more recent times, successful transplantation of tissues from one animal to another has become a reality, made possible by the development of the atomic bomb and the subsequent in- crease in our knowledge of radiation and its biologic effects. Research in the fields of radiation biology and medicine has brought new understanding of the fundamental principles of the im- mune mechanism' involved in tissue and organ transplantation, with the possibility of effecting cures. Even ten years ago, despite the fact that Roentgen discovered x-rays in 1895 and that they have been in use ever since, no treatment for post-irradiation damage was known. It was recog- nized, to be sure, that the biologic action of irradiation could be modified by pre-irradiation treatment. For example, Treadwell and Gardner 2 had shown in 1938 that mice given estrogens ten days before irradiation were able to survive dosages well above the lethal range. Similarly, in the late 1940's ~arron,~Patt 4 and Cronkite5 demonstrated that such sulfhydryl compounds as glutathione and cysteine would protect, provided that they were present at the time of irradi- ation. At about the same time, we ourselves were exploring the effect of lead protection of the spleen on regeneration of the blood-forming tissues following total-body irradiation. We real- ized that this procedure prevented radiation mortality even after lethal dosages. Furthermore, not only did the spleen itself hypertrophy and so prevent the fatal depression of the blood ele- ments, but the spl.een shielding was accompanied by a rapid regeneration of the bone marrow which had previously been depopulated. Other protective treatments such as transplantation of spleens of new-born mice, and intravenous injection of homogenates of spleen and embryo liver were also found to protect the mice from dosages well above the lethal range,6-8 and Lorenz9 expanded the list of protective hematopoietic tissues to include bone marrow cells. Thus, it be- came apparent that 28-day survival following administration of a lethal dose of radiation could *Summary of the address presented as part of a Panel Discussion on Bone Marrow Trans- plants and the General Immunological Problems, atthe Forty-Fifth Annual Meeting of the Radi- ological Society of North America, Chicago, Ill., November 15-20, 1959, and appearing in Radi- ology, 75:6, 1960. be enhanced by injection of a variety of hematopoietic tissues (even from such genetically dis- tinct species as the guinea pig and rat), into the irradiated mouse. Many explanations were put forward to account for the mechanism responsible for this re- covery. Among others, it was suggested that the transplanted cells detoxified a poison supposed- ly formed in the irradiated tissues, that the healthy cells were self-seeding, or that they re- leased some humoral substance which hastened the recovery of the damaged tissues. At this time we favored the humoral hypothesis because it seemed inconceivable that rat or guinea pig cells would not be rejected by the body of a mouse. From the outset it was obvious that isologous tissue, that is, tissue from the same inbred strain as the host, was capable of providing long-term survival against irradiation death from dosages often as high as twice the normal LD50. In 1954 however, a new phenomenon was ob- served which suggested that the injected cells actually colonized the weakened host. Evidence for this was presented by Barnes and out it" who discovered that although hematopoietic cells of a different strain or species would give excellent survival following the acute radiation cri- sis, the animals so treated worsened and slowly succumbed by 120 days to what came to be known as "secondary disease" or "homologous disease."
Load more

Recommended publications
  • Tariff Elimination Schedule of Canada
    Tariff Schedule of Canada Staging Tariff Item Tariff Description Rate Category 01011100 Pure-bred breeding animals Free A 01011900 Other Free A 01012000 Asses, mules and hinnies Free A 01021000 Pure-bred breeding animals Free A 01029000 Other Free A 01031000 Pure-bred breeding animals Free A 01039100 Weighing less than 50 kg Free A 01039200 Weighing 50 kg or more Free A 01041000 Sheep Free A 01042000 Goats Free A 01051110 For breeding purposes Free A 01051121 Within access commitment 0.86¢ each E 238% but not less than 30.8¢ 01051122 Over access commitment each E 01051190 Other Free A 01051210 For breeding purposes Free A 01051290 Other 8% A 01051910 For breeding purposes Free A 01051992 Guinea fowls 2.5% A 01051993 Ducks and geese 8% A For breeding purposes; Spent fowl; 01059210 Started pullets 2.82¢/kg A 01059291 Within access commitment 1.90¢/kg E 238% but not less than 01059292 Over access commitment $1.25/kg E For breeding purposes; Spent fowl; 01059310 Started pullets 2.82¢/kg A 01059391 Within access commitment 1.90¢/kg E 238% but not less than 01059392 Over access commitment $1.25/kg E 01059911 Within access commitment 1.90¢/kg E 154.5% but not less than 01059912 Over access commitment $1.60/kg E 01059990 Other 3% A 01060000 Other live animals. Free A 02011010 Within access commitment Free A 02011020 Over access commitment 26.5% E 02012010 Within access commitment Free A 02012020 Over access commitment 26.5% E 02013010 Within access commitment Free A 02013020 Over access commitment 26.5% E 02021010 Within access commitment Free
    [Show full text]
  • Factors Influencing Bone Fragility in Chickens
    Fragility ia :;aicken^r Fcic.actors Tnficenc^ng Bone By LENTOi-; 0. W\rL^'KD, JR. COUNCXJ, OF A DISSERTATION PKZSENTEO TO IBE GkA])U.A-Z FARTIA'u- THE. UNTVERSITY Or 7L0KIDA iK THE DEGREE GF FUI.^IL1.N^NT OF THE E3qUIRE>rr:NTS FOR DOCTOR OF PHIEOSOPKY irNI''/E?.SITi" OF FIATRIDA 1972 la the distance, A mournful wail of s train. It calls to all. Come wander with me. All hear. And a few obey. They are trapped. To them the call. Must be obeyed. They must follow. Thru sorrow and happiness. Follow it to the end. And even Further. K , L . Hayden (July 8, 1963) ACKNO\\T.FDGEl-ai:NTS to the The author wishes to express his dsepes; gratitude H. Har^ns, for chairiiian of his supervisory coTiuT.it tee, Dr. Robert continual encouragement his understanding, patience, assistance and Special appreciation is in the preparation of this dissertation. whose alsc expressed to Dr. Jack L. Fry and Dr. H. R. V7ilson made indispensable guidance, assistance, and helpful suggestions this research possible. and Sincere thanks are also extended to Dr. J. P. Feaster Dr. D. S. ^^ii.-hony for their interest and ccvmsel. the use of their Tlie Food Science Department is thanked for shear press. their Finally, the author wishes to thank his parents for careei understanding, enccurageicent, and guidance during his graduate 111 TABLE OF CONTENTS Page ACi'L^IOUT.^DGEMENTS iii LIST OF T^VBLES , v ABSTRACT vi INTRODUCTION 1 LITERATURE REVIEW 4 EXPERIMENT I C0:-7ARIS0N OF BONE STRENGTH OF CAGED A:>D FLOOR L^A'ERS AND FaDOSTERS 14 EXPERI^OiKT II THE EFFECT OF WIRE PENS, FLOOR PENS, AND CAGES ON BONE GLARACTERISTICS OF LAYING HENS 19 EXPERIMENT III INFLUENCE OF PROTAMONE AND DTENESTROL DIACETATE ON BONE FRAGILITY OF CAGED LAYERS 25 EXPERIMENT IV DIFFERENCES IN TIBIA STRENGTH AND BONE ASH AI'IONG STRAINS OF LAYERS 33 EXPHRIL'ENT V TIME PJ-QUIRED TO DEVELOP BONE FRAGILITY IN LAYING HENS 40 EXPERIMENT VI COKPARISONS OF EONE CHARACTERISTICS EZTwESN FL-OOR AND BATTERY- GROI-.'N BROILERS 47 SW!1-L^.Y 54 LIST OF REFERENCES 57 BIOGRAPHICAL SKETCH , 63 iv LIST OF TABLES Table Page 1.
    [Show full text]
  • Precautions Interactions Pharmacokinetics Uses and Administration
    2266 Sex Hormones and their Modulators sufficient to cause distress, has been described in a woman Preparations and is mainly excreted as peptide fragments in the faeces. given danazol for mastalgia. The hirsutism improved after About 20 to 30% of a dose is renally excreted. Degarelix is stopping the danazol.' ProprietaryPreparations (details are given in Volume B) injected to form a subcutaneous depot, and the I. Gately LE, Andes WA. Danazol and erythema multiforrne. Ann Intern Single-ingredient Preparations. Arg.: Ladoga!; Austral.: Azol; pharmacokinetics of the drug is strongly Influenced by the Med 1988; 109: 85. Danocrinet; Austria: Danokrin; Belg.: Danatrol; Braz.: Ladogal; concentration of the injected solution. After subcutaneous 2. Reynolds NJ, Sansom JE. Erythema multiforme during danazol therapy. Canad. : Cyclamen; China: Gong Fu Yi Kang (:g;ffl!jj>�); Cz. : injection of 240 mg at a concentration of 40 mg/mL, Clin Exp Dermato/ 1992; 17: 140. 3. Zawar V, Sankalecha C. Facial hirsutism following danazol therapy. Cutis Danoval; Fr.: Danatrol; Gr.: Danatrol; Hong Kong: Anargil; degarelix has a terminal half-life of about 43 to 53 days; after 2004; 74: 301-3. Azolt; Danocrine; Hung.: Danoval; India: Benzol; Danogen; maintenance doses of 80 mg as 20 mg/mL the half-life is Endozol; Gonablok; Gynadom; Gynazol; Gynodan; Ladoga!; about 28 days. Zendol; Indon.: Azol; Danocrine; Irl.: Danolt; Israel: Danol; Precautions Ital.: Danatrol; Jpn: Bonzol; Malaysia: Anargil; Azolt; Ladogal; Preparat ons Nazol; Mex. : Danalem; Ladogal; Novaprin; Neth.: Danatrol; NZ: i . Danazol should be used with caution in conditions that may ······························· ................................ Azol; D-Zolt; Philipp.: Ladoga!; Port. : Danatrol; Rus.: Danol ProprietaryPreparations (details are given in Volume B) be adversely affected by fluid retention, such as in (,!\aHon); Danoval (,!\aHoBaJJ); S.Afr.
    [Show full text]
  • Directory of Reference Standards 2010
    Directory of Reference Standards 2010 Reference Materials for Residue Analysis Product Codes Catalogue number XA10330100AC X solution 100 ng/μl A in ampoules Dr. Ehrenstorfer GmbH 10330100 Atrazine D5 AC Acetone Our business model is founded on Description: a clear philosophy: the provision of high quality products providing C certified neat added-value to our customers, E neat Y solution >= 101 ng/μl backed by superior customer X solution <= 100 ng/μl service. We passionately care L solution <= 10 ng/μl about the products and the service Z solution <= 1 ng/μl that we provide you! A in ampoules Our aims are to create value for our AB Aceton/Benzene customers, business partners and AC Acetone our employees and to build a AD Acetone D6 company, that our customers and AH Acetone/H2O business partners admire and one AL Acetonitrile in which our employees have AM Acetone/Methanol 1:1 enormous pride. BE Benzene BM Benzene/Methanol We have a committment to quality CT Cyclohexane/Toluene 1:1 and distinction in the development CY Cyclohexane and delivery of dependable, high DE 1,2-Dichloroethane quality solutions, which serve your DH Diethylether needs. DI Dichloromethane DM DMF With this in mind we are pleased DO Deuteriumoxide to present our latest Directory of EA Ethylacetate Reference Materials. EL Ethanol HE n-Hexane We appreciate your interest and IO Iso-Octane look forward to serving your needs IP Isopropanol now and in the future. IT Iso-Octane/Toluene MB Methyl-tert. butyl ether ME Methanol MO Mineral Oil MW Methanol/H20 PE n-Pentane TH Toluene/Hexane TO Toluene WA Water www.analytical-standards.com Dr.
    [Show full text]
  • Tariff Schedule of Canada
    Tariff Schedule of Canada Tariff Item Description of Goods Base Rate Staging Category 0101.10.00 Pure-bred breeding animals Free A 0101.90.00 Other Free A 0102.10.00 Pure-bred breeding animals Free A 0102.90.00 Other Free A 0103.10.00 Pure-bred breeding animals Free A 0103.91.00 Weighing less than 50 kg Free A 0103.92.00 Weighing 50 kg or more Free A 0104.10.00 Sheep Free A 0104.20.00 Goats Free A 0105.11.10 For breeding purposes Free A 0105.11.21 Broilers for domestic production: Within access 0.86¢ each A commitment 0105.11.22 Broilers for domestic production: Over access 238% but not less E commitment than 30.8¢ each 0105.11.90 Other Free A 0105.12.10 For breeding purposes Free A 0105.12.90 Other 8% A 0105.19.10 For breeding purposes Free A 0105.19.92 Other: Guinea fowls 2.5% A 0105.19.93 Other: Ducks and geese 8% A 0105.94.10 For breeding purposes; 2.82¢/kg A Spent fowl; Started pullets 0105.94.91 Other: Within access commitment 1.90¢/kg C 0105.94.92 Other: Over access commitment 238% but not less E than $1.25/kg 0105.99.11 Turkeys: Within access commitment 1.90¢/kg C 0105.99.12 Turkeys: Over access commitment 154.5% but not less E than $1.60/kg 0105.99.90 Other 3% A 0106.11.00 Primates Free A 0106.12.00 Whales, dolphins and porpoises (mammals of the order Free A Cetacea); manatees and dugongs (mammals of the order Sirenia) 0106.19.00 Other Free A 0106.20.00 Reptiles (including snakes and turtles) Free A 0106.31.00 Birds of prey Free A 0106.32.00 Psittaciformes (including parrots, parakeets, macaws and Free A cockatoos) 0106.39.00
    [Show full text]
  • Pharmaceutical and Veterinary Compounds and Metabolites
    PHARMACEUTICAL AND VETERINARY COMPOUNDS AND METABOLITES High quality reference materials for analytical testing of pharmaceutical and veterinary compounds and metabolites. lgcstandards.com/drehrenstorfer [email protected] LGC Quality | ISO 17034 | ISO/IEC 17025 | ISO 9001 PHARMACEUTICAL AND VETERINARY COMPOUNDS AND METABOLITES What you need to know Pharmaceutical and veterinary medicines are essential for To facilitate the fair trade of food, and to ensure a consistent human and animal welfare, but their use can leave residues and evidence-based approach to consumer protection across in both the food chain and the environment. In a 2019 survey the globe, the Codex Alimentarius Commission (“Codex”) was of EU member states, the European Food Safety Authority established in 1963. Codex is a joint agency of the FAO (Food (EFSA) found that the number one food safety concern was and Agriculture Office of the United Nations) and the WHO the misuse of antibiotics, hormones and steroids in farm (World Health Organisation). It is responsible for producing animals. This is, in part, related to the issue of growing antibiotic and maintaining the Codex Alimentarius: a compendium of resistance in humans as a result of their potential overuse in standards, guidelines and codes of practice relating to food animals. This level of concern and increasing awareness of safety. The legal framework for the authorisation, distribution the risks associated with veterinary residues entering the food and control of Veterinary Medicinal Products (VMPs) varies chain has led to many regulatory bodies increasing surveillance from country to country, but certain common principles activities for pharmaceutical and veterinary residues in food and apply which are described in the Codex guidelines.
    [Show full text]
  • Prospective Performance Evaluation of Selected Common Virtual Screening Tools
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector European Journal of Medicinal Chemistry 96 (2015) 445e457 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.elsevier.com/locate/ejmech Original article Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2 Teresa Kaserer a, Veronika Temml a, Zsofia Kutil b, c, Tomas Vanek b, Premysl Landa b, * Daniela Schuster a, a Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria b Laboratory of Plant Biotechnologies, Institute of Experimental Botany AS CR. v.v.i., Rozvojova 263, 165 02 Prague 6 e Lysolaje, Czech Republic c Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, 165 21 Prague6e Suchdol, Czech Republic article info abstract Article history: Computational methods can be applied in drug development for the identification of novel lead can- Received 10 December 2014 didates, but also for the prediction of pharmacokinetic properties and potential adverse effects, thereby Received in revised form aiding to prioritize and identify the most promising compounds. In principle, several techniques are 20 February 2015 available for this purpose, however, which one is the most suitable for a specific research objective still Accepted 7 April 2015 requires further investigation. Within this study, the performance of several programs, representing Available online 8 April 2015 common virtual screening methods, was compared in a prospective manner.
    [Show full text]
  • LD5655.V856 1978.B46.Pdf (6.074Mb)
    , FERMENTATION, UTILIZATION, AND PALATABILITY OF SWINE WASTE ENSILED WITH VARIOUS PROPORTIONS OF GROUND ORCHARDGRASS HAY OR GROUND CORN GRAIN, by Jerry Carl Albert Berger. Dissertation suktmitted to the Graduate Faculty of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Animal. Science APPROVED: 1 P, Retent Co-Chairman E. T. Kornegay, Co-Chairman a 7 oat yi a % o Oe Une, iu, D, Fron < K. E. We b, Ir. W. D. Lamm ROA) fF ; - A / r a G Cia pae — ae Vb S vas ~ C. E. Polan M. B. Wise, Department Head December, 1978 Blacksburg, Virginia Nee ACKNOWLEDGEMENTS The author is deeply indebted to the Virginia Agricultural Foundation without whose financial assistance this study would not have been possible. The author wishes to express his sincere appreciation to all individuals whose assistance and encouragement permitted completion of this study and graduate program. To the members of his graduate committee, Dr. E. T. Xornegay, Co-chaizman, Dr. J. P. Fontenot, Co-chairman, Dr. K. E. Webb, Jr., Dr. R. E. Blaser, Dr. C. E. Polan, Dr. W. D. Lamm and Dr. M. B. Wise, the author expresses his thanks for their encouragement and assistance. The author would especially like to thank Dr. E. T. Kornegay and Dr. J. P. Fontenot for their expert guidance, patience, and encouragement throughout preparation of this manuscript and his graduate study. To Dr. K. E. Webb, Jr., the author is indebted for his technical assistance, patience, insight, and invaluable encouragement. Thanks and sincere appreciation is extended to Mrs.
    [Show full text]
  • Diethylstilbestrol(BAN, Rinn)
    2094 Sex Hormones and their Modulators powder. It is odourless. Practically insoluble in water; soluble in USP 31 (Diethylstilbestrol). A white, odourless, crystalline pow- of 40 years the risk increased to 1.91 (95% confidence interval alcohol, in acetone, in ether, in methyl alcohol, in propylene gly- der. Practically insoluble in water; soluble in alcohol, in chloro- 1.09 to 3.33). The risk appeared to increase further with greater col, and in solutions of alkali hydroxides; slightly soluble in chlo- form, in ether, in fatty oils, and in dilute alkali hydroxides. Store age, but the relatively small number of cases in women aged 50 roform and in fatty oils. in airtight containers. Protect from light. years and over made this harder to establish. Profile 1. Bibbo M, et al. A twenty-five-year follow-up study of women (BANM, rINNM) exposed to diethylstilbestrol during pregnancy. N Engl J Med Dienestrol is a synthetic nonsteroidal oestrogen structurally relat- Diethylstilbestrol Dipropionate 1978; 298: 763–7. ed to diethylstilbestrol (p.2094). It has been used as a 0.01% Diéthylstilbestrol, Dipropionate de; Diethylstilbestroli Dipropio- 2. Clark LC, Portier KM. Diethylstilbestrol and the risk of cancer. cream in the treatment of menopausal atrophic vaginitis. If used nas; Dipropionato de dietilestilbestrol; Stilboestrol Dipropionate. N Engl J Med 1979; 300: 263–4. 3. Greenberg ER, et al. Breast cancer in mothers given diethyl- on a long-term basis in women with a uterus a progestogen is (E)-αβ-Diethylstilbene-4,4′-diol dipropionate. required. stilbestrol in pregnancy. N Engl J Med 1984; 311: 1393–8.
    [Show full text]
  • Adverse Effects and Precautions Interactions Pharmacokinetics
    2267 of monophasic combined oral contraceptive preparations. ette; Gr. : Cerazette; Hong Kong: Cerazette; Hung. : Azalia; Cer­ Doses of 50 to 150 micrograms daily may be used in triphasic azette; India: Cerazette; Indon.: Cerazette; Irl. : Cerazette; combined preparations. A dose of 75 micrograms daily is Israel: Cerazette; Ital.: Cerazet; Cerazette; Mex.: Cerazette; used as an oral progestogen -only contraceptive; unlike Neth.: Cerazette; Norw.: Cerazette; NZ: Cerazette; Philipp.: traditional progestogen-only contraceptives, desogestrel is Cerazette; Pol.: Azalia; Cerazette; Port.: Cerazette; Rus.: Ceraz­ ('lap03erra); (JlaKTHHer); Spain: said to reliably inhibit ovulation. Progestogen-only ette Lactinette Azalia; Cerazet; Swed.: Cerazette; Switz. : Cerazette; Thai.: Cerazette; UK: contraceptive efficacy is reduced if a dose of desogestrel is Aizea; Cerazette; Cerelle; Zelleta; Ukr.: Cerazette (qapo3erra); Dienogest is a nonethinylated progestogen (see Progester­ delayed by more than 12 hours. Lactinette (JlaK.TnHer); Venez.: Arlette; Cerazette. one, p. 2300.2) structurally related to nortestosterone. It is reported to have anti-androgenic properties. Dienogest is The effects of a progestogen-only Arg.: Aus­ Contraception. Multi-ingredient Preparations. Marvelon; Mercilon; used as the progestogen component of some combined oral contraceptive containing desogestrel have been tral. : Marvelon; Austria: Gracial; Liberel; Marvelon; Mercilon; contraceptives (see p. 2231.3). A dose of 2mg daily is reported.1·3 Oral desogestrel has also been investigated as Belg.: Desorellet; Gracial; Marvelon; Mercilon; Ovidol; Braz.: typically used in monophasic preparations, and doses of 2 or a male contraceptive, combined with testosterone given Femina; Gestradiol; Gracia]; Malu; Mercilon Conti; Merdlon; 3 mg daily may be found in multiphasic sequential by intramuscular injection,4 subcutaneous implant,5•6 or Microdiol; Minian; Novial; Primera; Primeravintet; Canad.
    [Show full text]
  • Annex I Headnote 1. the Schedule of a Party Sets Out, Pursuant to Article
    Annex I Headnote 1. The Schedule of a Party sets out, pursuant to Article 809 (Investment - Non- Conforming Measures) and Article 906 (Cross-Border Trade in Services - Non- Conforming Measures), the reservations taken by that Party with respect to existing measures by a Party that do not conform with obligations imposed by: (a) Articles 803, 902 (Investment, Cross-Border Trade in Services - National Treatment); (b) Articles 804, 903 (Investment, Cross-Border Trade in Services - Most- Favoured-Nation Treatment); (c) Article 905 (Cross-Border Trade in Services - Local Presence); (d) Article 807 (Investment - Performance Requirements); (e) Article 808 (Investment - Senior Management and Boards of Directors); (f) Article 904 (Cross-Border Trade in Services - Market Access); and, in certain cases, sets out commitments for immediate or future liberalization. 2. Each reservation sets out the following elements: (a) Sector refers to the general sector in which the reservation is taken; (b) Sub-Sector refers to the specific sector in which the reservation is taken; (c) Industry Classification refers, where applicable, to the activity covered by the reservation according to domestic industry classification codes; (d) Type of Reservation specifies the obligation referred to in paragraph 1 for which a reservation is taken; (e) Measures identifies the laws, regulations or other measures, as qualified, where indicated, by the Description element, for which the reservation is taken. A measure cited in the Measures element: (i) means the measure as amended, continued or renewed as of the date of entry into force of this Agreement, and (ii) includes any subordinate measure adopted or maintained under the authority of and consistent with the measure; (f) Description sets out commitments, if any, for liberalization on the date of entry into force of this Agreement, and the remaining non-conforming aspects of the existing measures for which the reservation is taken.
    [Show full text]
  • Sigma Biochemical Condensed Phase
    Sigma Biochemical Condensed Phase Library Listing – 10,411 spectra This library provides a comprehensive spectral collection of the most common chemicals found in the Sigma Biochemicals and Reagents catalog. It includes an extensive combination of spectra of interest to the biochemical field. The Sigma Biochemical Condensed Phase Library contains 10,411 spectra acquired by Sigma-Aldrich Co. which were examined and processed at Thermo Fisher Scientific. These spectra represent a wide range of chemical classes of particular interest to those engaged in biochemical research or QC. The spectra include compound name, molecular formula, CAS (Chemical Abstract Service) registry number, and Sigma catalog number. Sigma Biochemical Condensed Phase Index Compound Name Index Compound Name 8951 (+)-1,2-O-Isopropylidene-sn-glycerol 4674 (+/-)-Epinephrine methyl ether .HCl 7703 (+)-10-Camphorsulfonic acid 8718 (+/-)-Homocitric acid lactone 10051 (+)-2,2,2-Trifluoro-1-(9-anthryl)ethanol 4739 (+/-)-Isoproterenol .HCl 8016 (+)-2,3-Dibenzoyl-D-tartaric acid 4738 (+/-)-Isoproterenol, hemisulfate salt 8948 (+)-2,3-O-Isopropylidene-2,3- 5031 (+/-)-Methadone .HCl dihydroxy-1,4-bis- 9267 (+/-)-Methylsuccinic acid (diphenylphosphino)but 9297 (+/-)-Miconazole, nitrate salt 6164 (+)-2-Octanol 9361 (+/-)-Nipecotic acid 9110 (+)-6-Methoxy-a-methyl-2- 9618 (+/-)-Phenylpropanolamine .HCl naphthaleneacetic acid 4923 (+/-)-Sulfinpyrazone 7271 (+)-Amethopterin 10404 (+/-)-Taxifolin 4368 (+)-Bicuculline 4469 (+/-)-Tetrahydropapaveroline .HBr 7697 (+)-Camphor 4992 (+/-)-Verapamil,
    [Show full text]