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Budesonide Nasal Irrigation Improved Lund–Kennedy Endoscopic Score of Chronic Rhinosinusitis Patients After Endoscopic Sinus Surgery

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Budesonide Nasal Irrigation Improved Lund–Kennedy Endoscopic Score of Chronic Rhinosinusitis Patients After Endoscopic Sinus Surgery European Archives of Oto-Rhino-Laryngology (2019) 276:1397–1403 https://doi.org/10.1007/s00405-019-05327-6 RHINOLOGY Budesonide nasal irrigation improved Lund–Kennedy endoscopic score of chronic rhinosinusitis patients after endoscopic sinus surgery Zi‑zhen Huang1 · Xian‑zhen Chen2 · Jian‑cong Huang1 · Zhi‑yuan Wang1 · Xia Li1 · Xiao‑hong Chen1 · Xiao‑ping Lai1 · Li‑hong Chang1 · Ge‑hua Zhang1 Received: 25 November 2018 / Accepted: 31 January 2019 / Published online: 20 February 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract Purpose Budesonide improves the prognosis of chronic rhinosinusitis (CRS). However, few reports have examined whether its use for nasal irrigation, compared to normal saline, improves the prognosis of patients after endoscopic sinus surgery (ESS). We compared the effects of nasal irrigation with budesonide and normal saline in CRS patients after ESS. Methods Sixty CRS patients who had undergone ESS were randomly divided into an experimental group (30 patients), which used budesonide nasal irrigation, and a control group (30 patients), which used normal saline nasal irrigation. All patients received regular follow-up evaluations and were assessed via questionnaires, including the Lund–Kennedy endoscopic score (LKES), the symptom visual analog scale (VAS), the 22-item Sino-Nasal Outcome Test (SNOT-22), the Short-Form 36-Item Questionnaire (SF-36), the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS) and a side effects scale. Results Scores of polyposis, mucosal edema, secretions and total score of LKES; VAS scores of nasal blockage, hyposmia and rhinorrhea; and SNOT-22 results in both groups were significantly improved 3 months after ESS. Scores of polyposis, mucosal edema, secretions and scarring and total score of LKES in experimental group were significantly better than in control group 3 months after ESS. No significant differences were observed in SF-36, SAS or SDS before or 3 months after ESS within or between the two groups. The side effects of the two groups were not significantly different. Conclusions Nasal irrigation improved the prognosis of CRS patients after ESS. Budesonide nasal irrigation had a better effect than normal saline nasal irrigation. Keywords Budesonide · Irrigation · Chronic rhinosinusitis · Prognosis · Endoscopy Introduction Chronic rhinosinusitis (CRS) is a chronic inflammation of the nose and the paranasal sinuses lasting 12 weeks or longer without complete resolution of symptoms [1]. It is a common health problem worldwide. In China, the overall Zi-zhen Huang and Xian-zhen Chen contributed equally to this article. prevalence of CRS is 8.0% [2], and in Europe and the USA, the overall prevalence is 10.9% [3] and 14% [4], respectively. * Li-hong Chang CRS is strongly associated with asthma at all ages (adjusted [email protected] OR: 11.85). In the absence of nasal allergies, CRS is posi- * Ge-hua Zhang tively associated with late-onset asthma [5]. [email protected] As a severe health problem, CRS affects individual qual- 1 Department of Otolaryngology-Head and Neck Surgery, ity of life (QoL), societies and economies worldwide. The The Third Affiliated Hospital of Sun Yat-sen University, symptoms of CRS include nasal blockage, rhinorrhea, loss No. 600, Tianhe Road, Guangzhou 510630, Guangdong, of smell, facial pain and symptoms derived from lower air- People’s Republic of China way involvement; these symptoms significantly affect the 2 Department of Otolaryngology-Head and Neck Surgery, QoL of patients and have negative effects on physical health, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519020, Guangdong, People’s Republic of China Vol.:(0123456789)1 3 1398 European Archives of Oto-Rhino-Laryngology (2019) 276:1397–1403 sleep, social functioning, mental health and general health, and a control group via simple randomization according leading to workplace absenteeism [6–8]. to a random number table. Surgery was unilateral or bilat- The goal of CRS treatment is to achieve and maintain eral and consisted of removing all gross polyps and suf- clinical control after appropriate treatment (recommended ficiently widening the natural ostia of all affected sinuses medication and surgery). Although the majority of CRS to allow access for topical medications. The experimental patients can achieve control, some patients will not, and group used topical corticosteroid (budesonide dissolved CRS has a high potential for recurrence even with maximal in normal saline) nasal irrigation and the control group medical therapy and surgery [1]. This characteristic makes used normal saline nasal irrigation. All patients were CRS a severe problem, and improving the prognosis of CRS also prescribed conventional oral antibiotics, mucolyt- patients is important and urgent. ics, expectorants, nasal steroid sprays and antihistamines We reviewed the literature and analyzed the effects of after ESS. Patients performed postoperative nasal irriga- nasal irrigation with various solutions on the prognosis of tion once daily for 6 days postoperatively after the first patients with CRS after endoscopic sinus surgery (ESS). A cleaning of the nasal cavity and sinus, and each patient’s total of 824 studies were included, and 5 were included in medication records were reviewed. Only patients who a systematic review. The effects of the following solutions used budesonide or normal saline nasal irrigation therapy for the treatment of the CRS patients (331 cases) after ESS for 3 months while complying with oral antibiotic, nasal were reviewed: lactated Ringer’s solution-electrolyzed acid steroid spray, mucolytic, expectorant and antihistamine water, amphotericin B, hyaluronan plus saline and sulfur- use were included in the study. The Lund–Kennedy endo- ous–arsenical–ferruginous thermal water. Nasal irrigation scopic score (LKES), visual analog scale (VAS) of CRS with these five solutions was effective in CRS patients after symptoms, 22-item SinoNasal Outcome Test (SNOT-22) ESS and significantly improved symptoms and nasal endos- results, Short-Form 36-Item Questionnaire (SF-36) results, copy scores. However, the results were not significantly dif- Self-Rating Anxiety Scale (SAS) scores, Self-Rating ferent from those of normal saline use alone. Since normal Depression Scale (SDS) scores and reported CRS-related saline is less expensive and safer, we concluded that normal absenteeism were recorded pre- and postoperatively for saline was the first and best choice for nasal irrigation [9]. all patients. All patients underwent regular follow-up Nasal steroids play an important role in the postopera- evaluations after ESS and provided VAS scores of CRS tive management of patients with CRS. However, com- symptoms, LKES and scale assessments. In addition, we mercially available nasal steroid sprays may not deliver recorded the side effects, including a nasal burning sen- adequate amounts of medication to the entire postoperative sation, nasal itching, nasal pain, epistaxis, headache, ear nasal and sinus cavity because of polyposis, mucosal edema, pain, cough, nausea and vomiting, postnasal drip, aural secretions, scarring and crusting after ESS. Off-label use of fullness and dizziness. We performed a paired parametric budesonide nasal irrigation can theoretically deliver concen- statistical analysis (Student’s t test) to compare outcomes trated steroid solution to the entire postoperative nasal and for all visits. Any visit in which a patient reported no use sinus cavity through a high-pressure, high-volume system. of budesonide nasal irrigation or normal saline nasal irri- Moreover, budesonide can remain in the sinus cavity for a gation was categorized as “without nasal irrigation” and long time and is the only topical corticosteroid that has been was not included in the analysis. This prospective cohort proven to improve the prognosis of CRS. Several studies study was approved by the Medical Ethics Committee at have demonstrated the safety of budesonide nasal irriga- the Third Affiliated Hospital of Sun Yat-sen University. In tion [10–14], but few reports have examined its efficacy and our practice, most CRS patients are prescribed short-term whether its use for nasal irrigation could improve the prog- conventional oral antibiotics, mucolytics and expectorants nosis of CRS patients after ESS compared to normal saline. and a long-term regimen consisting of nasal saline irriga- We performed a study to compare the effects of nasal irri- tion, nasal steroid sprays and antihistamines. gation with budesonide and normal saline in CRS patients after ESS. Statistical analysis Materials and methods Statistical analysis was performed with IBM® SPSS Statis- tics version 20.0 (IBM SPSS, Armonk, NY). Demographic This study was a prospective cohort analysis of prospec- and clinical data are expressed as the means and SDs, and tively collected data. All patients with or without polyps other data are expressed as the means and SEMs. Student’s had undergone primary ESS for CRS by a single surgeon t test, the rank-sum test and the Mann–Whitney U test were in our department between May 2017 and January 2018. used to compare groups. Significance was defined at the CRS patients were divided into an experimental group P < 0.05 level. 1 3 European Archives of Oto-Rhino-Laryngology (2019) 276:1397–1403 1399 Results No significant differences were found in the VAS scores for nasal blockage, hyposmia, rhinorrhea or facial pain There were 30 patients in the
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