Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer

DEPARTMENTS Book Review

R.M. Reilly, ed.

Hoboken, NJ: John Wiley and Sons, 2010, 624 pages, $149.95

Radioimmunotherapy and peptide-directed radiotherapy elements. Unique aspects of this book include a trans- of solid tumors have been restricted by low tumor uptake; lational focus on development and evaluation of targeted dose-limiting toxicity to normal tissues, including the bone radiopharmaceuticals for treating tumors, discussions marrow; and an intrinsic radioresistance. However, the suc- on health economics issues and the utility of targeted cess of radioimmunotherapy of non-Hodgkin lymphoma has radiotherapy, and new areas such as molecular imaging, proven that this approach is scientifically sound, translatable the bystander effect, and combined radioimmunotherapy. to clinical practice, and feasible. Continuing to gain momen- This book delivers a wealth of information to push future tum as a novel treatment strategy, targeted radiotherapy relies discovery for targeted radiotherapy. A review of the cur- on and exploits the characteristics of malignant cells to attack rent state of the art in the radioimmunotherapy field tumors with radiation. provides insight from today’s cancer researchers as they Thirty-five internationally well-recognized scientists reach for tomorrow’s cures. have written this book to cover a range of diverse topics Most figures are black and white, but that appears to pose associated with targeted radiotherapy, including the opti- no problem in illustrating the key points. The tables and mization of biomolecule design and radiochemistry, cell index are helpful, and the references are updated. This book and animal models for preclinical trials, radiation biology is suitable for students and trainees in the field of radio- and dosimetry, and considerations in regulatory approval. immunotherapy and for physicians in nuclear medicine, This book consists of 17 chapters dealing with antibody radiation, and medical oncology. The book will also be of engineering, radiochemistry of antibodies and peptides, interest to any research workers who look for new avenues radioimmunotherapy of radiolabeled peptides, peptide re- to more effective killing of cancer cells. ceptor radionuclide therapy, radioimmunotherapy of central nervous system tumors, lymphoma and leukemia, pretar- E. Edmund Kim geted radioimmunotherapy, Auger electron therapy, viral M.D. Anderson Cancer Center introduction of receptors, cell and tumor models, radiation 1515 Holcombe Blvd., Unit 1264 biology, dosimetry, the bystander effect, evaluation of Houston, TX 77030 tumor response, economic attractiveness, and regulatory E-mail: [email protected]

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