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| Hai Lama Altina Alta Li Ma Tu Na Maana Haiti |HAI LAMA ALTINA ALTAUS010076546B2 LI MA TU NA MAANA HAITI (12 ) United States Patent (10 ) Patent No. : US 10 ,076 , 546 B2 Henn et al. (45 ) Date of Patent: * Sep . 18 , 2018 (54 ) NETWORK - BASED MICROBIAL 3 ,608 ,030 A 11/ 1971 Grant COMPOSITIONS AND METHODS 4 ,077 ,227 A 3 / 1978 Larson 4 , 205 , 132 A 5 / 1980 Sandine 4 ,655 ,047 A 4 / 1987 Temple (71 ) Applicant : Seres Therapeutics , Inc ., Cambridge , 4 ,689 ,226 A 8 / 1987 Nurmi MA (US ) 4 ,839 ,281 A 6 / 1989 Gorbach et al. 5 , 196 , 205 A 3 / 1993 Borody (72 ) Inventors : Matthew R . Henn , Somerville , MA 5 ,425 ,951 A 6 / 1995 Goodrich 5 ,436 , 002 A 7 / 1995 Payne (US ) ; David N . Cook , Brooklyn , NY 5 , 443 , 826 A 8 / 1995 Borody (US ) ; Toshiro K . Ohsumi, Cambridge , 5 , 599 , 795 A 2 / 1997 McCann MA (US ) ; Mary - Jane Lombardo 5 . 648 , 206 A 7 / 1997 Goodrich McKenzie , Arlington , MA (US ) ; Kevin 5 ,951 , 977 A 9 / 1999 Nisbet et al. D . 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C . 154 (b ) by 0 days . 8 , 034 , 601 B2 10 / 2011 Boileau 8 , 039, 006 B2 10 / 2011 Prato This patent is subject to a terminal dis 8 , 147, 482 B2 4 / 2012 Shimizu claimer. 8 ,187 , 590 B2 5 / 2012 Farmer 8 , 236 , 508 B2 8 / 2012 Mutharasan 8, 388 ,996 B2 3 / 2013 Gehling ( 21) Appl. No. : 14/ 777, 252 8 ,460 , 648 B2 6 /2013 Borody ( 22 ) PCT Filed : Mar. 17, 2014 (Continued ) ( 86 ) PCT No. : PCT/ US2014 / 030817 FOREIGN PATENT DOCUMENTS § 371 (c )( 1 ), | 006847 B1 4 / 2006 ( 2 ) Date : Sep . 15 , 2015 EN 0033584 A3 1 / 1981 (Continued ) ( 87) PCT Pub . No. : WO2014 /145958 PCT Pub . Date : Sep . 18 , 2014 OTHER PUBLICATIONS Aas , J . ,Gessert , C . E . , and Bakken , J . S . (2003 ). Recurrent Clostridium (65 ) Prior Publication Data difficile colitis : case series involving 18 patients treated with donor US 2016 /0030494 A1 Feb . 4 , 2016 stool administered via a nasogastric tube. Clinical Infectious Dis eases 36 ( 5 ) , 580 -585 . Abrams, R . S . , " Open - Label , Uncontrolled Trial of Bowel Steriliza Related U . S . Application Data tion and Repopulation with Normal Bowel Flora for Treatment of Inflammatory Bowel Disease, " Current Therapeutic Research , Dec . (60 ) Provisional application No . 61 / 798 , 666 , filed on Mar. 1997 , pp . 1001 - 1012 , vol. 58 , No . 12 . 15 , 2013 . Achtman , M . , and Wagner, M . (2008 ) . Microbial diversity and the (51 ) Int. Ci. genetic nature of microbial species . Nat . Rev . Microbiol. 6 ( 6 ) , A61K 35 / 74 ( 2015 . 01 ) 431 -440 . A61K 35 / 742 ( 2015 .01 ) (Continued ) A61K 35 / 741 ( 2015 .01 ) A61K 35 / 745 ( 2015 . 01 ) Primary Examiner — Oluwatosin A Ogunbiyi ( 52 ) U .S . CI. CPC . .. .. .. A61K 35 / 742 ( 2013 .01 ) ; A61K 35 / 74 ( 74 ) Attorney , Agent, or Firm — Fenwick & West LLP ( 2013 .01 ) ; A61K 35 / 741 ( 2013 .01 ) ; A61K 35 / 745 (2013 . 01 ) (57 ) ABSTRACT (58 ) Field of Classification Search None Provided are therapeutic compositions containing combina See application file for complete search history . tions of bacteria , for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mam ( 56 ) References Cited malian subject, and methods for use thereof. U . S . PATENT DOCUMENTS 3 ,009 , 864 A 11/ 1961 Gordon - Aldterton et al . 12 Claims, 21 Drawing Sheets 3 ,228 ,838 A 1 / 1966 Rinfret Specification includes a Sequence Listing . US 10 ,076 ,546 B2 Page 2 (56 ) References Cited WO WO 1997 /009886 AL 3 / 1997 Wo WO 98 / 26787 A 6 / 1998 U . S . PATENT DOCUMENTS WO WO 2000 /010582 A2 3 / 2000 WO WO 01/ 93904 Al 12 / 2001 8 , 906 ,668 B2 12 / 2014 Henn et al. wo WO 2002 /007741 A1 1 /2002 9 , 011, 834 B14 /2015 McKenzie et al. 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