Product Name: RB1CC1 Polyclonal Antibody, Cy3 Conjugated Catalog No. : TAP01-91835R-Cy3 Intended Use: For Research Use Only. Not for used in diagnostic procedures.

Size 100ul Concentration 1ug/ul Gene ID 9821 ISO Type Rabbit IgG Clone N/A Immunogen Range 515-550/1594 Conjugation Cy3 Subcellular Locations

Applications IF(IHC-P) Cross Reactive Species Human, Mouse, Rat Source KLH conjugated synthetic peptide derived from human RB1CC1 Applications with IF(IHC-P)(1:50-200) Dilutions Purification Purified by Protein A. Background Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation andnegatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potentregulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways. Synonyms CC1; ATG17; FIP200; PPP1R131; RB1-inducible coiled-coil protein 1; FAK family kinase-interacting protein of 200 kDa; RB1CC1; KIAA0203; RBICC

Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

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