PUBLICATIONS

AIDS DeBeck K, Kerr T, Li K, Milloy M-J, Montaner JS, Milloy M-J, Buxton J, Wood E, Li K, Montaner Wood E. Incarceration and drug use patterns JS, Kerr T. Elevated HIV risk behaviour among Harrigan, Dr. Paul R. among a cohort of injection drug users. recently incarcerated injection drug users in a Addiction, 2009; 104(1): 69-76. Canadian setting: a longitudinal analysis. BMC Brumme Z, John M, Carlson J, Brumme C, Public Health. 2009; 9(1): 156. Chan D, Brockman M, Swenson L, Tao I, Szeto Lloyd-Smith E, Wood E, Li K, Montaner JS, Kerr S, Rosato P, Sela J, Kadie C, Frahm N, Brander T. Incidence and determinants of initiation into Lloyd-Smith E, Wood E, Zhang R, Tyndall C, Haas D, Riddler S, Haubrich R, Walker B, cocaine injection and correlates of frequent M, Montaner JS, Kerr T. Determinants of Harrigan PR, Heckerman D, Mallal S. HLA- cocaine injectors. Drug & Alcohol Dependence, cutaneous injection-related infection care associated immune escape pathways in HIV-1 2009; 99(1-3):176-182. at a supervised injecting facility. Annals of subtype B Gag, Pol and Nef proteins. PLoS One. Epidemiology, 2009; 19(6): 404-409. 2009 August 19; 4(8):e6687. Marshall B, Kerr T. Shoveller J, Montaner JS, Wood E. Structural factors associated with an Kerr T, Marshall B, Miller C, Shannon Kate, Wang D, Larder B, Revell A, Montaner JS, increased risk of HIV and sexually transmitted Zhang R, Montaner JS, Wood E. Injection drug Harrigan PR, De Wolf F, Lange J, Wegner S, Ruiz infection transmission among street-involved use among street-involved youth in a Canadian L, Perez-Elias, MJ, Emery S, Gatell J, D’Arminio youth. BMC Public Health, 2009; 9(1) 7. setting. BMC Public Health, 2009; 9(1): 171. Monforte A, Torti C, Zazzi M, Lane C. A comparison of three computational modelling DeBeck K, Wood E, Montaner JS, Kerr T. Canada’s Wood E, Kerr T, Marshall B, Li K, Zhang R, methods for the prediction of virological new federal “national anti-drug strategy”: an Harrigan P, Hogg R, Montaner JS. Longitudinal response to combination therapy. Artificial informal audit of reported funding allocation. community plasma HIV-1 RNA levels and HIV-1 Intelligence in Medicine. 2009 September; International Journal of Drug Policy, 2009; 20(2): incidence among injection drug users. BMJ, 47(1):63-74. 188-191. 2009; 338: b1649.

Hull M, Lima V, Hogg R, Harrigan PR, Montaner Shannon K, Strathdee S, Shoveller J, Rusch M, Grebely J, Raffa J, Lai C, Krajden M, Kerr T, JS. Epidemiology of treatment failure: a focus on Kerr T, Tyndall M. Structural and environmental Fischer B, Tyndall M. Low uptake of treatment recent trends. Current Opinion in HIV and AIDS. barriers to condom use negotiation with clients for hepatitis C virus infection in a large 2009 November; 4 (6);467-473. among female sex workers: implications for community-based study of inner city residents. HIV-prevention strategies and policy. American Journal of Viral Hepatitis, 2009; 16(5): 352- Poon A, Swenson L, Dong W, Deng W, Journal of Public Health, 2009; 99(4): 659-665. 358. Kosakovsky Pond S, Brumme Z, Mullins J, Richman D, Harrigan PR, Frost S. Phylogenetic Hadland S, Kerr T, Li K, Montaner JS, Wood E. Small W, VanBorek N, Fairbairn N, Wood E, Analysis of Population-Based and Deep Access to drug and alcohol treatment among a Kerr T. Access to health and social services Sequencing Data to Identify Coevolving Sites in cohort of street-involved youth. Drug and Alcohol for IDU: the impact of a medically supervised the nef Gene of HIV-1. Molecular Biology and Dependence, 2009; 101(1-2): 1-7. injection facility. Drug and Alcohol Review, Evolution. 2009 December 2. [Epub ahead of 2009, 28: 341-346. print]. Miller C, Kerr T, Fischer B, Zhang R, Wood E. Methamphetamine injection independently Krüsi A, Small W, Wood E, Kerr T. An integrated Bousheri S, Burke C, Ssewanyana I, Harrigan predicts hepatitis C injection among street supervised injecting program within a PR, Emenyonu N, Hunt P, Bangsberg D, Cao involved youth in a Canadian setting. Journal of care facility for HIV-positive individuals: a H. Infection with different HIV subtypes is Adolescent Health, 2009; 44(3): 302-304. qualitative evaluation. AIDS Care, 2009; 21 (5): associated with CD4 activation-associated 638-644. dysfunction and apoptosis. Journal of Acquired Marshall B, Wood E, Zhang R, Tyndall M, Immune Deficiency Syndrome. 2009 December; Montaner JS, Kerr T. Condom use among Rachlis B, Kerr T, Montaner JS, Wood E. 52(5):548-52. injection drug users accessing a supervised Harm reduction in hospitals: is it time? Harm injecting facility. Sexually Transmitted Infections, Reduction Journal, 2009; 6 (1): 19. Kerr, Dr. Thomas H. 2009; 85(2):121-126. Werb D, Hayashi K, Fairbairn N, Kaplan K, Fast D, Small W, Wood E, Kerr T. Coming ‘down Marshall B, Kerr T, Shoveller J, Patterson T, Suwannawong P, Lai C, Kerr T. Drug use here’: young people’s reflections on becoming Buxton J, Wood E. Homelessness and unstable patterns among Thai illicit drug users amidst entrenched in a local drug scene. Social Science housing associated with an increased risk of increased police presence. Substance Abuse & Medicine, 2009 Oct; 69 (8):1204-10. HIV and STI transmission among street-involved Treatment, Prevention, and Policy, 2009; 4 (1): youth. Health & Place, 2009; 15(3): 753-760. 16. Rachlis B, Wood E, Zhang R, Montaner JS, Kerr T. High rates of homelessness among a cohort Wood E, Werb D, Marshall B, Montaner JS, Kerr Small W, Wood E, Betteridge G, Montaner of street-involved youth. Health & Place, 2009; T. The war on drugs: one of recent history’s most J, Kerr T. The impact of incarceration upon 15(1): 10-17. devastating public policy disasters. The Lancet. adherence to HIV treatment among HIV- 2009; 373(9668): 989-990. positive injection drug users: a qualitative Martin I, Palepu A, Wood E, Li K, Montaner JS, study. AIDS Care, 2009; 21 (6): 708-714. Kerr T. Violence among street-involved youth: Wood E, Marshall B, Lai C, Kerr T. Increase in the role of methamphetamine. European fatal methamphetamine overdoses in a Canadian Milloy M-J, Buxton J, Montaner JS, Kerr T, Addiction Research, 2009; 15(1): 32-8. setting. American Journal on Addictions, 2009; Wood E. Methamphetamine use and rates of 18(3): 248-249. incarceration among street-involved youth in DeBeck K, Small W, Wood E, Li K, Montaner a Canadian setting: a cross-sectional analysis. JS, Kerr T. Public injecting among a cohort of Small W, Fast D, Krüsi A, Wood E, Kerr T. Social Substance Abuse Treatment, Prevention, and injection drug users in Vancouver, Canada. J Epi influences upon injection initiation among Policy, 2009; 4(1): 17. & Community Health, 2009; 63(1): 81-86. street-involved youth in Vancouver, Canada: a qualitative study. Substance Abuse Treatment, Prevention, and Policy, 2009, 4(1): 8.

1 | Annual Report 2009 Publication List

Shannon K, Kerr T, Strathdee S, Shoveller Druyts EF, Yip B, Lima VD, Burke TA, Kesovski D, Druyts EF, Yip B, Lima VD, Burke TA, Lesovski D, J, Montaner JS, Tyndall M. Prevalence and Fernandes KA, McInnes CW, Rustad CA, Fernandes KA, McInnes CW, Rustad CA, structural correlates of gender-based violence Montaner JSG, Hogg RS. Health care services Montaner JSG, Hogg RS. Health care services among a prospective cohort of female sex utlization stratified by virological and utilization stratified by virological and workers. BMJ, 2009; 339:b2939. immunological markers of HIV: evidence from immunological markers of HIV: evidence from a universal health care setting. HIV Medicine a universal health care setting. HIV Medicine Kim C, Kerr T, Li Kathy, Zhang R, Tyndall M, 2009;10:88-93. 2009;10:88-93. Montaner JS, Wood E. Unstable housing and hepatitis C incidence among injection drug users Hull MW, Harris M, Lima V, Guillemi S, Harrigan Hadland S, Kerr T, Li K, Montaner JS, Wood E. in a Canadian setting. BMC Public Health, 2009; PR, Montaner JSG. Lopinavir/ritonavir Access to drug and alcohol treatment among a 9 (1): 270. pharmacokinetics in a substitution of high-dose cohort of street-involved youth. Drug Alcohol soft-gelatin capsule to tablet formulation. J Clin Depend. Drug and Alcohol Dependence, 2009; Wong J, Marshall B, Kerr T, Lai C, Wood E. Pharmacol 2009;49:155-61. 101(1-2): 1-7. Addiction treatment experience among a cohort of street-involved youth and young adults. Lima VD, Fink V, Yip B, Hogg RS, Harrigan PR, Harrigan PR, Lima V, Montaner JS. Reconsidering Journal of Child and Adolescent Substance Montaner JS. Association between HIV-1 RNA first-line antiretroviral therapy in resource- Abuse, 2009; 81 (4): 398-409. level and CD4 cell count among untreated HIV- limited settings: the need for operational infected individuals. Am J Public Health research. The Journal of Infectious Diseases. Grebely J, Raffa J, Lai C, Krajden M, Kerr 2009;99(S1):S193-96. 2009 May 1; 199(9):1407-8. T, Fischer B and Tyndall M. Low uptake of treatment for hepatitis C virus infection in Lloyd-Smith E, Wood E, Li K, Montaner JS, Kerr T. Harris M, Cote H, Ochoa C, Allavena C, Negredo a large community-based study of inner Incidence and determinants of initiation into E, Thorne A, Cahn P, Zala C, Raffi F, Clotet B, city residents in Vancouver. Journal of Viral cocaine injection and correlates of frequent Singer J, Montaner J. A Randomized, Open-label Hepatitis, 2009 May;16(5):352-8. cocaine injectors. Drug & Alcohol Dependence. Study of a Nucleoside Analogue Reverse 2009 Jan 1;99(1-3):176-82. Transcriptase Inhibitor Sparing Regimen in Kerr T, Stoltz J, Marshall B, Lai C, Strathdee Antiretroviral-Naïve, HIV-Infected Patients. J S, Wood E. Childhood trauma and injection Marshall BDL, Kerr T, Shoveller JA, Montaner Acquir Immune Defic Syndr 2009;50(3):335-337. drug use among high-risk youth. Journal of JSG, Wood E. Structural factors associated with Adolescent Health, 2009 Sep;45(3):300-2. an increased risk of HIV and sexually transmitted Hull MW, Lima VD, Hogg RS, Harrigan PR, infection transmission among street-involved Montaner JS. Epidemiology of treatment failure: Fast D, Small W, Wood E, Kerr T. Coming ‘down youth. BMC Public Health 2009;9(7). a focus on recent trends. Curr Opin HIV AIDS here’: young people’s reflections on becoming 2009;4(6):467-473. PubMed PMID: 20048712 entrenched in a local drug scene. Social Science Martin I, Palepu A, Wood E, Li K, Montaner JS, & Medicine, 2009 Oct;69(8):1204-10. Kerr T. Violence among street-involved youth: Hull M, Harris M, Montaner JSG. When to start the role of methamphetamine. European antiretroviral therapy in HIV-positive treatment- Hayashi K, Milloy M-J, Fairbairn N, Kaplan K, Lai Addiction Research. 2009;15(1):32-8. naïve adult patients. European Infectious C, Wood E, Kerr T. Incarceration experiences Disease 2009;3: 26-30. among a community-recruited sample of Anema A, Lima VD, Johnston K, Levy A, injection drug users in Bangkok, Thailand. BMC Montaner JSG. Expanded highly active Kerr T, Marshall B, Miller C, Shannon K, Zhang R, Public Health, 2009, 9: 492. antiretroviral therapy coverage-a powerful Montaner JS, Wood E. Injection drug use among strategy to curb progression to AIDS, death and street-involved youth in a Canadian setting. DeBeck K, Kerr T, Li K, Fischer B, Buxton J, new infections. European Infect Dis 2009. BMC Public Health, 2009; 9(1): 171. Montaner JS, Wood E. Smoking of crack cocaine as a risk factor for HIV infection among people Barraclough K, Er L, Ng F, Harris M, Montaner J, Kim C, Kerr T, Li K, Zhang R, Tyndall MW, who use injection drugs. CMAJ, 2009; 181(9): Levin A. A comparison of the predictive Montaner JSG, Wood E. Unstable housing and 585-589. performance of different methods of kidney hepatitis C incidence among injection drug function estimation in a well-characterized use in a Canadian setting. BMC Public Health Montaner, Dr. Julio S. HIV-infected population. Nephron Clin Pract 2009;9:270. 2009;111(1):c39-48. Alfonso V, Toulson A, Bermbach N, Erskine Y, Kitahata MM, Gange SJ, Abraham AG, Merriman Montaner J. Psychosocial issues influencing Calmy A, Vallier N, Nguyen A, Lange JM, B, Saag M, Justice A, Hogg RS et al. Effect of treatment adherence in patients on multidrug Battegay M, de Wolf F, Reiss P, Lima VD, Hirschel early versus deferred antiretroviral therapy for rescue therapy: Perspectives from patiens and B, Hogg RS, Yip B, Montaner JS, Wit FW. Safety HIV on survival (J Montaner, PI-Research Site). their health care providers. AIDS Patient Care & and efficacy of once-daily nevirapine dosing: a New Eng J Med 2009;360(18):1815-26. STDs 2009;23(2):119-26. multicohort study. Antivir Ther. 2009; 14(7):931- 8. PubMed PMID: 19918097 Lima V, Fernandes Ki, Rachlis B, Druyts E, DeBeck K, Wood E, Montaner JS, Kerr T. Montaner J, Hogg R. Migration adversely affects Canada’s new federal “national anti-drug Debeck K, Kerr T, Li K, Fischer B, Buxton J, antiretroviral adherence in a population-based strategy”: an informal audit of reported funding Montaner JS, Wood E. Smoking of crack cocaine cohort of HIV/AIDS patients. Soc Sci Med. 2009 allocation. International Journal of Drug Policy as a risk factor for HIV infection among people Mar; 68(6):1044-9. Epub 2009 PubMed PMID: 2009 Mar;20(2):188-91. who use injection drugs. Canadian Medical 19157668. Association Journal, 2009; 181(9): 585-589. DeBeck K, Kerr T, Li K, Milloy MJ, Montaner J, Lima VD, Harrigan R, Bangsberg DR, Hogg RS, Wood E. Incarceration and drug use patterns Druyts EF, Rachlis BS, Lima VD, Harvard SS, Gross R, Yip B, Montaner JS. The combined among a cohort of injection drug users. Zhang W, Brandson EK, Strathdee SA, Montaner effect of modern highly active antiretroviral Addiction. 2009 Jan;104(1):69-76. JSG, Hgg RS. Mortality is influenced by locality therapy regimens and adherence on mortality in a major HIV/AIDS epidemic. HIV Medicine over time. J Acquir Immune Defic Syndr DeBeck K, Small W, Wood E, Li K, Montaner JS, 2009;10:274-81. 2009;50(5):529-36. Kerr T. Public injecting among a cohort of injection drug users in Vancouver, Canada. J Epi & Community Health. 2009 Jan;63(1):81-6.

Publication List Annual Report 2009 | 2

Lima VD, Harrigan R, Montaner JSG. Increased Wood E, Kerr T, Marshall DL, Li K, Zhang R, Hogg DeBeck K, Small W, Wood E, Li K, Montaner reporting of detectable plasma HIV-1 RNA levels RS, Harrigan PR, Montaner JSG. Longitudinal JS, Kerr T. Public injecting among a cohort of at the critical threshold of 50 copies/mL community plasma HIV-1 RNA concentrations injection drug users in Vancouver, Canada. J Epi with the Taqman Assay in comparison to the and incidence of HIV-1 among injecting & Community Health. 2009 Jan;63(1):81-6. Amplicor Assay. J Acquir Immune Defic Syndr drug users: prospective cohort study. BMJ 2009;51:3-6. 2009;338;b1649. Marshall B, Kerr T, Shoveller J, Montaner JS, Wood E. Structural factors associated with an Lloyd-Smith E, Wood E, Zhang R, Tyndall M, Wood E, Werb D, Marshall B, Montaner JS, Kerr increased risk of HIV and sexually transmitted Montaner JS, Kerr T. Determinants of cutaneous T. The war on drugs: a devastating public policy infection transmission among street-involved injection-related infection care at a supervised disaster. Lancet. 2009; 373(9668): 989-990. youth. BMC Public Health, 2009; 9(1): 7. injecting facility. Annals of Epidemiology, 2009; 19(6): 404-409. Moore, Dr. David M. Lloyd-Smith E, Wood E, Li K, Montaner JS, Kerr T. Incidence and determinants of initiation into Marshall BDL, Wood E, Zhang R, Tyndall MW, Forna F, Moore D, Mermin J, Brooks JT, Were W, cocaine injection and correlates of frequent Montaner JSG, Kerr T. Condom use among Buchacz K, Campbell JD, Downing R, Borkowf cocaine injectors. Drug & Alcohol Dependence. injection drug users accessing a supervised CB, Weidle PJ. Hematologic Changes Associated 2009 Jan 1;99(1-3):176-82. injecting facility. Sexually Transmitted Infections With Zidovudine Following Single-Drug 2009;85(2):121-126. Substitution From Stavudine in a Home-Based DeBeck K, Wood E, Montaner JS, Kerr T. AIDS Care Program in Rural Uganda. J Int Assoc Canada’s new federal “national anti-drug McInnes CW, Druyts E, Harvard SS, Gilbert M, Physicians AIDS Care. 2009 Mar 6. strategy”: an informal audit of reported funding Tyndall MW, Lima VD, Wood E, Montaner JSG, allocation. International Journal of Drug Policy. Hogg RS. HIV/AIDS in Vancouver, British Were W, Moore D, Ekwaru P, Mwima G, Bunnell 2008 June 18. 2009 Mar;20(2):188-91. Columbia: a growing epidemic. Harm Reduction R, Kaharuza F, Rutherford G, Mermin J. A simple J 2009;6(5). screening tool for active tuberculosis in Marshall BDL, Wood E. Sex work and sex HIV-infected adults receiving antiretroviral exchange among street children: an urgent need Milloy MJ, Buxton J, Wood E, Li K, Montaner JS, treatment in Uganda. Int J Tuberc Lung Dis. 2009 for a global response. Journal of Adolescent Kerr T. Elevated HIV risk behaviour among Jan;13(1):47-53. Health. 2009;44(3):201-202. recently incarcerated injection drug users in a Canadian setting: a longitudinal analysis. BMC Homsy J, Bunnell R, Moore D, King R, Malamba Marshall B, Kerr T, Shoveller J, Patterson T, Public Health. 2009; 9(1): 156. S, Nakityo R, Glidden D, Tappero J, Mermin J. Buxton J, Wood E. Homelessness and Unstable Reproductive intentions and outcomes among Housing Associated with an Increased Risk of Milloy MJ, Kerr T, Buxton J, Montaner JS, women on antiretroviral therapy in rural HIV and STI Transmission among Street-Involved Wood E. Methamphetamine use and rates of Uganda: a prospective cohort study. PLoS ONE. Youth. Health & Place, 2009; 15(3): 753-760. incarceration among street-involved youth in 2009;4(1):e4149. Epub 2009 Jan 8. a Canadian setting: a cross-sectional analysis. Milloy MJ, Wood E, Tyndall M, Lai C, Montaner Substance Abuse Treatment, Prevention, and Moore DM, Harris R, Lima V, Hogg B, May M, Yip JS, Kerr T. Recent incarceration and use of a Policy, 2009; 4(1): 17. B, Justice A, Mocroft A, Reiss P, Lampe F, supervised injection facility in Vancouver, Chêne G, Costagliola D, Elzi L, Mugavero Canada. Addiction Research and Theory, 2009; Phillips P, Lee JK, Wang C, Yoshida E, Lima VD, MJ, Monforte AD, Sabin C, Podzamczer D, 17(5): 538-515. Montaner J. Chylous ascites: a late complication Fätkenheuer G, Staszewski S, Gill J, Sterne JA; of intra-abdominal Mycobacterium avium Antiretroviral Therapy Cohort Collaboration. Wong J, Marshall B, Kerr T, Lai C, Wood E. complex immune reconstitution syndrome in Clinical significance of short-term immunologic Addiction treatment experience among a cohort HIV-infected patients. International J STD & responses to antiretroviral therapy in individuals of street-involved youth and young adults. AIDS 2009;20:285-87. with virologic suppression. 2009 J Acquir Journal of Child and Adolescent Substance Immune Defic Syndr 2009 Nov 1;52(3):357-63 Abuse, 2009; 81 (4): 398-409. Rachlis B, Kerr T, Montaner JS, Wood E. Harm reduction in hospitals: is it time? Harm Shannon, Dr. Kate Krüsi A, Small W, Wood E, Kerr T. An integrated Reduction Journal, 2009; 6 (1): 19. supervised injecting program within a care Kerr T, B Marshall, C Miller, K Shannon, JS facility for HIV-positive individuals: a qualitative Rachlis B, Wood E, Zhang R, Montaner JS, Kerr T. Montaner, E Wood. Injection drug use among evaluation. AIDS Care, 2009; 21 (5): 638-644. High rates of homelessness among a cohort of street-involved youth in a Canadian setting. street-involved youth. Health & Place, 2009; BMC Public Health, 2009; 9: 171. Small W, Wood E, Betteridge G, Montaner J, Kerr 15(1): 10-17. T. The impact of incarceration upon adherence Shannon K, SA Strathdee, M Rusch, J Shoveller, T to HIV treatment among HIV-positive injection Shannon K, Kerr T, Strathdee S, Shoveller Kerr, MW Tyndall. Structural and environmental drug users: a qualitative study. AIDS Care, 2009; J, Montaner JS, Tyndall M. Prevalence and barriers to condom negotiation with clients 21 (6): 708-714. structural correlates of gender-based violence among female sex workers: Implications for among a prospective cohort of female sex HIV prevention strategies and policy. American DeBeck K, Kerr T, Li K, Milloy MJ, Montaner JS, workers. BMJ, 2009; 339:b2939. Journal of Public Health. 2009; 99(4):659-65. Wood E. Incarceration and drug use patterns among a prospective cohort of injection drug Small W, Wood E, Betteridge G, Montaner J, Kerr users. Addiction, 2009; 104(1): 69-76. T. The impact of incarceration upon adherence Wood, Dr. Evan to HIV treatment among HIV-positive injection Kerr T, Stoltz J, Marshall B, Lai C, Strathdee drug users: a qualitative study. AIDS Care, 2009; Martin I, Palepu A, Wood E, Li K, Montaner JS, S, Wood E. Childhood trauma and injection 21 (6): 708-714. Kerr T. Violence among street-involved youth: drug use among high-risk youth. Journal of the role of methamphetamine. European Adolescent Health, 2009; 45(3): 300-302. Weiser SD, Fernandes KA, Brandson E, Lima VD, Addiction Research. 2009;15(1):32-8. Anema A, Bangsberg DR, Montaner JS, Hogg RS. Kim C, Kerr T, Li K, Zhang R, Tyndall M, Montaner The association between food insecurity and DeBeck K, Kerr T, Li K, Milloy MJ, Montaner J, JS, Wood E. Unstable housing and hepatitis C mortality among HIV-infected individuals on Wood E. Incarceration and drug use patterns incidence among injection drug users in a HAART.Journal of acquired immune deficiency among a cohort of injection drug users. Canadian setting. BMC Public Health, 2009; 9 syndromes (1999) 2009; 52(3):342-9. PMID: Addiction. 2009 Jan; 104(1):69-76. (1): 270. 19675463. 3 | Annual Report 2009 Publication List

Kerr T, Marshall B, Miller C, Shannon K, Zhang R, Wood E, Kerr T, Marshall B, Li K, Zhang R, ALLERGY & IMMUNOLOGY Montaner JS, Wood E. Injection drug use among Harrigan P, Hogg R, Montaner JS. Longitudinal street-involved youth in a Canadian setting. community plasma HIV-1 RNA levels and HIV-1 BMC Public Health, 2009; 9(1): 171. incidence among injection drug users. BMJ, Schellenberg, Dr. Robert R. 2009; 338: B1649. Rachlis B, Wood E, Zhang R, Montaner JS, Kerr T. Keith PK, Koch C, Djandji M, Bouchard J, High rates of homelessness among a cohort of Des Jarlais D, Arasteh K, Semaan S, Wood Psaradellis E, Sampalis JS, Schellenberg RR, street-involved youth. Health & Place, 2009; E. HIV among injecting drug users: current McIvor RA. Montelukast as add-on therapy 15(1): 10-17. epidemiology, biologic markers, respondent- with inhaled corticosteroids alone or inhaled driven sampling, and supervised-injection corticosteroids and long-acting beta-2-agonists Milloy MJ, Wood E. Emerging role of supervised facilities. Current Opinion in HIV and AIDS, 2009; in the management of patients diagnosed with injecting facilities in human immunodeficiency 4(4): 308-313. asthma and concurrent allergic rhinitis (the virus prevention. Addiction, 2009; 104(4): 620- RADAR trial). Can Respir J. 16 Suppl A:17A-31A. 621. Small W, VanBorek N, Fairbairn N, Wood E, Kerr 2009. T. Access to health and social services for IDU: Werb D, Wood E. Commentary on Vorobjov et the impact of a medically supervised injection Schellenberg RR. Oral Corticosteroids in Asthma. al., “Comparison of injection drug users who facility. Drug and Alcohol Review, 2009, 28: Allergy & Asthma. 17-20, 2009. obtain syringes from pharmacies and syringe 341-346. exchange programs in Tallinn, Estonia”. Harm Wong, Dr. H. C. George Reduction Journal. 2009 March; 6(1): 33. Rachlis B, Kerr T, Montaner JS, Wood E. Harm reduction in hospitals: is it time? Harm Wong HCG. Patient consent. BC Med J 2009; Hadland S, Kerr T, Li K, Montaner JS, Wood E. Reduction Journal, 2009; 6 (1): 19. 51(1):8. Access to drug and alcohol treatment among a cohort of street-involved youth. Drug Alcohol Milloy MJ, Kerr T, Buxton J, Montaner JS, Wong HCG. Re: Let’s support naturopathy. BC Depend. Drug and Alcohol Dependence, 2009; Wood E. Methamphetamine use and rates of Med J 2009; 51(6):244-245. 101(1-2): 1-7. incarceration among street-involved youth in a Canadian setting: a cross-sectional analysis. Miller C, Kerr T, Fischer B, Zhang R, Wood E. Substance Abuse Treatment, Prevention, and CARDIOLOGY Methamphetamine injection independently Policy, 2009; 4(1): 17. predicts hepatitis C injection among street Buller, Dr. Christopher E. involved youth in a Canadian setting. Journal of Fast D, Small W, Wood E, Kerr T. Coming ‘down Adolescent Health, 2009; 44(3): 302-304. here’: young people’s reflections on becoming entrenched in a local drug scene. Social Science Menon V, Pearte CA, Buller CE, Steg PG, Forman Wood E, Lai C, Marshall B, Kerr T. Increase & Medicine, 2009 Oct; 69 (8):1204-1210. SA, White HD, Marino PN, Katritsis DG, in fatal methamphetamine overdoses in Caramori P, Lasevitch R, Loboz-Grudzien K, a Canadian setting. American Journal on Wood E, Kerr T, Marshall B, Li K, Zhang R, Zurakowski A, Lamas GA, Hochman JS. Lack Addictions, 2009; 18(3): 248-249. Harrigan P, Hogg R, Montaner JS. Longitudinal of benefit from percutaneous intervention of community plasma HIV-1 RNA concentrations persistently occluded infarct arteries after the Marshall B, Wood E, Zhang R, Tyndall M, and incidence of HIV-1 among injecting drug acute phase of myocardial infarction is time Montaner JS, Kerr T. Condom use among users: prospective cohort study. British Medical independent: insights from Occluded Artery injection drug users accessing a supervised Journal, 2009; 338: b1649 Trial. Eur Heart J. 2009;30:183-91. injecting facility. Sexually Transmitted Infections, 2009; 85(2):121-126. Fairbairn N, Kaplan K, Hayashi K, Suwannawong Rashba EJ, Lamas GA, Couderc JP, Hollist SM, P, Lai C, Wood E, Kerr T. Reports of evidence Dzavik V, Ruzyllo W, Fridrich V, Buller CE, Forman McInnes C, Druyts E, Harvard S, Gilbert M, planting by police among a community-based SA, Kufera JA, Carvalho AC, Hochman JS. Tyndall M, Lima V, Wood E, Montaner JS, Hogg sample of injection drug users in Bangkok, Electrophysiological effects of late percutaneous R. HIV/AIDS in Vancouver, British Columbia: a Thailand. BMC International Health and Human coronary intervention for infarct-related growing epidemic. Harm Reduction Journal, Rights, 2009; 9(1): 24. coronary artery occlusion: the Occluded Artery 2009, 6 (1):5. Trial-Electrophysiological Mechanisms (OAT-EP). Debeck K, Kerr T, Li K, Fischer B, Buxton J, Circulation. 2009;119:779-87. Wood E, Werb D, Marshall B, Montaner JS, Kerr Montaner JS, Wood E. Smoking of crack cocaine T. The war on drugs: a devastating public policy as a risk factor for HIV infection among people Džavik V, Buller CE, Devlin G, Carere RG, disaster. Lancet. 2009; 373(9668): 989-990. who use injection drugs. Canadian Medical Mancini GB, Cantor WJ, Buszman PE, Rankin Association Journal, 2009; 181(9): 585-589. JM, Vozzi C, Ross JR, Forman S, Barton BA, Lloyd-Smith E, Wood E, Zhang R, Tyndall M, Lamas AG, Hochman JS. Angiographic and Montaner JS, Kerr T. Determinants of cutaneous Nevirapine Toxicity Multicohort Collaboration. clinical outcomes of drug-eluting versus bare injection-related infection care at a supervised Risk factors for treatment-limiting toxicities metal stent deployment in the Occluded Artery injecting facility. Annals of Epidemiology, 2009; in patients starting nevirapine-containing Trial. Catheter Cardiovasc Interv. 2009 May 19(6): 404-409. antiretroviral therapy. AIDS, 2009; 23(13): 1689- 1;73(6):771-779. 1699. Small W, Fast D, Krüsi A, Wood E, Kerr T. Social Fung AY, Saw J, Starovoytov A, Densem C, influences upon injection initiation among Antiretroviral Therapy Cohort Collaboration Jokhi P, Walsh SJ, Fox RS, Humphries KH, street-involved youth in Vancouver, Canada: a (ART-CC). Variable impact on mortality of AIDS- Aymong E, Ricci DR, Webb JG, Hamburger JN, qualitative study. Substance Abuse Treatment, defining events diagnosed during combination Carere RG, Buller CE. Abbreviated infusion Prevention, and Policy, 2009, 4(1): 8. antiretroviral therapy: not all AIDS-defining of eptifibatide after successful coronary conditions are created equal. Clinical Infectious intervention The BRIEF-PCI (Brief Infusion of Milloy MJ, Buxton J, Wood E, Li K, Montaner JS, Diseases, 2009; 48(8): 1138-1151. Eptifibatide Following Percutaneous Coronary Kerr T. Elevated HIV risk behaviour among Intervention) randomized trial. J Am Coll Cardiol. recently incarcerated injection drug users in a Hayashi K, Milloy M-J, Fairbairn N, Kaplan K, Lai 2009;53:837-45. Canadian setting: a longitudinal analysis. BMC C, Wood E, Kerr T. Incarceration experiences Public Health. 2009; 9(1): 156. among a community-recruited sample of injection drug users in Bangkok, Thailand. BMC Public Health, 2009, 9:492. Publication List Annual Report 2009 | 4

Jokhi PP, Ramanathan K, Walsh S, Fung AY, Saw Fung, Dr. Anthony Wood DA, Tops LF, Mayo JF, Pasupati S, Schalij J, Fox RS, Zalunardo N, Buller CE. Experience of MJ, Humphries KH, Lee M, Al Ali A, Munt B, stenting for atherosclerotic renal artery stenosis Fung AY, Saw J, Starovoytov A, Densem C, Jokhi Moss R, Thompson CR, Bax JJ, Webb JG. in a cardiac catheterization laboratory: technical P, Walsh SJ, Fox RS, Humphries KH, Aymong E, Role of Multislice Computed Tomography in considerations and complications. Can J Cardiol. Ricci DR, Webb JG, Hamburger JN, Carere RG, Transcatheter Aortic Valve Replacement. Am J 2009;25:e273-8. Buller CE. Abbreviated Infusion of Eptifibatide Cardiol. 2009 May 1;103(9):1295-301. after Successful Coronary Intervention: Buller CE, Rankin JM, Carere RG, Buszman PE, The BRIEF-PCI Randomized Trial. J Am Coll Lear SA, Humphries KH, Hage-Moussa S, Pfisterer ME, Dzavik V, Thomas B, Forman S, Cardiology, 2009; 58: 837-45. Chockalingam A, Mancini GB. Immigration Ruzyllo W, Mancini GB, Michalis LK, Abreu PF, presents a potential increased risk for Lamas GA, Hochman JS. Percutaneous coronary Hamburger JN, Walsh SJ, Khurana R, Ding L, atherosclerosis. Atherosclerosis. 2009 intervention in the Occluded Artery Trial: Gao M, Humphries KH, Carere R, Fung AY, Aug;205(2):584-9. Epub 2009 Jan 9. procedural success, hazard, and outcomes over Mildenberger RR, Simkus GJ, Webb JG, Buller 5 years. Am Heart J. 2009;158:408-15. CE. Percutaneous Coronary Intervention and Jackevicius CA, Cox JL, Carreon D, Tu JV, Rinfret 30-Day Mortality: The British Columbia PCI S, So D, Johansen H, Kalavrouziotis D, Demers V, Hamburger JN, Walsh SJ, Khurana R, Ding L, Risk Score. Catheterization and Cardiovascular Humphries K, Pilote L; Canadian Cardiovascular Gao M, Humphries KH, Carere R, Fung AY, Interventions, 2009; 74:377-385. Outcomes Research Team Long-term trends Mildenberger RR, Simkus GJ, Webb JG, Buller in use of and expenditures for cardiovascular CE. Percutaneous coronary intervention and P. Jokhi, K Ramanathan, S Walsh, AY Fung, J Saw, medications in Canada.CMAJ. 2009 Jul 7;181(1- 30-day mortality: the British Columbia PCI risk RS Fox, N Zalunardo, CE Buller. Experience of 2):E19-28. score. Catheter Cardiovasc Interv. 2009;74:377- stenting for atherosclerotic renal artery stenosis 85. in a cardiac catheterization laboratory: Technical Webb JG, Altwegg L, Boone RH, Cheung A, Ye J, considerations and complications. Canadian Lichtenstein S, Lee M, Masson JB, Thompson C, Madan M, Nikhil J, Hellkamp AS, Pieper KS, Journal of Cardiology, August 2009, Volume 25 Moss R, Carere R, Munt B, Nietlispach F, Labinaz M, Cohen EA, Buller CE, Cantor WJ, Issue 8: e273-e278. Humphries K. Transcatheter aortic valve Seidelin P, Ducas J, Carere RG, Natarajan MK, implantation: impact on clinical and valve- O’Shea JC, Tcheng JE. Effect of operator and Andrade J, Stadnick E, Fung A. Thrombolysis related outcomes. Circulation. 2009 Jun institutional volume on clinical outcomes in Pulmonary Embolism. Canadian Journal of 16;119(23):3009-16. Epub 2009 Jun 1. after percutaneous coronary interventions General Internal Medicine, 2009; 4 (1): 34-36. performed in Canada and the United States: a Richardson L, Hemsing N, Greaves L, Assanand brief report from the Enhanced Suppression of Saw J, Walsh SJ, Teal P, Starovoytov A, Fox S, Allen P, McCullough L, Bauld L, Humphries K, the Platelet glycoprotein IIb/IIIa Receptor with R, Jokhi P, Fung AY. Carotid Artery Stenting Amos A. Preventing smoking in young people: Integrilin Therapy (ESPRIT) study. Can J Cardiol. Experience by Interventional Cardiologists in a a systematic review of the impact of access 2009;25:e269-72. Canadian Cardiac Catheterization Laboratory. interventions. Int J Environ Res Public Health. Canadian Journal of General Internal Medicine, 2009 Apr;6(4):1485-514. Epub 2009 Apr 20. Kandzari DE, Rao SV, Moses JW, Dzavik V, Strauss Dec 2009. BH, Kutryk MJ, Simonton CA, Garg J, Lokhnygina Cook RC, Humphries KH, Gin K, Janusz MT, Y, Mancini GB, Yeoh E, Buller CE. Clinical and Gin, Dr. Kenneth G. Slavik RS, Bernstein V, Tholin MT, Lee MK. angiographic outcomes with sirolimus-eluting Prophylacatic Intravenous Magnesium Sulfate stents in total coronary occlusions: the ACROSS/ Cook RC, Humphries KH, Gin K, Janusz MT, in Addition to Oral ß-blockade does not TOSCA-4 (Approaches to Chronic Occlusions Slavik RS, Bernstein V, Tholin MT, Lee MK. prevent Atrial Arrhythmias after Coronary With Sirolimus-Eluting Stents/Total Occlusion Prophylacatic Intravenous Magnesium Sulfate Artery or Valvular Heart Surgery. A Randomized Study of Coronary Arteries-4) trial. JACC in Addition to Oral ß-blockade does not Clinical Trial. Circulation. 2009 Sep 15;120(11 Cardiovasc Interv. 2009;2:97-106. prevent Atrial Arrhythmias after Coronary Suppl):S163-9. Artery or Valvular Heart Surgery. A Randomized Fleischmann KE, Beckman JA, Buller CE, Clinical Trial. Circulation. 2009 Sep 15;120(11 Thanassoulis G, Karp I, Humphries K, Tu, JV, et al. 2009 ACCF/AHA Focused Update on Suppl):S163-9. Eisenberg MJ, Pilote L. Impact of restrictive Perioperative Beta Blockade. J Am Coll Cardiol prescription plans on heart failure medication 2009;54:2102-2128. use. Circ Cardiovasc Qual Outcomes. 2009 Hamburger, Dr. Jaap Sep;2(5):484-90. Epub 2009 Sep 1. Cairns, Dr. John A. Hamburger JN, Walsh SJ, Khurana R, Ding L, Hamburger JN, Walsh SJ, Khurana R, Ding L, Gao Cairns JA. Effect of clopidogrel added to aspirin Gao M, Humphries KH, Carere R, Fung AY, M, Humphries KH, Carere R, Fung AY, in patients with atrial fibrillation. ACP Journal Mildenberger RR, Simkus GJ, Webb JG, Buller Mildenberger RR, Simkus GJ, Webb JG, Buller Club. 2009. CE. Percutaneous coronary intervention and CE. Percutaneous coronary intervention and 30-day mortality: the British Columbia PCI risk 30-day mortality: the British Columbia PCI risk score. Catheter Cardiovasc Interv. 2009;74:377- Carere, Dr. Ronald G. score. Catheter Cardiovasc Interv. 2009 Sep 85. 1;74(3):377-85. Ye J, Cheung A, Lichtenstein SV, Altwegg LA, Wong DR, Carere RG, Thompson CR, Moss RR, Humphries, Dr. Karin H. Richardson L, Hemsing N, Greaves L, Assanand Munt B, Pasupati S, Boone RH, Masson JB, S, Allen P, McCullough L, Bauld L, Humphries K, Al Ali A, Webb JG. Transapical transcatheter Fung AY, Saw J, Starovoytov A, Densem C, Jokhi Amos A. Preventing smoking in young people: a aortic valve implantation: 1 year outcome P, Walsh SJ, Fox RS, Humphries KH, Aymong E, systematic review of the impact of access in 26 patients (in process citation). J Thorac Ricci DR, Webb JG, Hamburger JN, Carere RG, interventions. Int J Environ Res Public Health. Cardiovasc Surg 2009 Jan;137(1):p167-73. Buller CE. Abbreviated Infusion of Eptifibatide 2009 Apr;6(4):1485-514. Epub 2009 Apr 20. after Successful Coronary Intervention: The BRIEF-PCI Randomized Trial. J Am Coll Cardiol Ignaszewski, Dr. Andrew P. 2009;53:837-45. Bayliss M, Andrade J, Heydari B, Ignaszewski AP. Jeremy Swan and the pulmonary atery catheter: Paving the way for effective hemodynamic monitoring. BC Medical Journal. Vol.51 NO. 7, 302-307, 2009. 5 | Annual Report 2009 Publication List

Lin D, Hollander Z, Ng RT, Imai C, Ignaszewski AP, M. Assessing the need for nuclear cardiology Kandzari DE, Rao SV, Moses JW, Dzavik V, Balshaw R, Freue G, Wilson-Mcmanus J, Qasimi and other advanced cardiac imaging modalities Strauss BH, Kutryk MJ, Simonton CA, Garg J, P, Meredith A, Mui A, Triche T, McMaster R, Phil in the developing world. J Nucl Cardiol. 16:956- Lokhnygina Y, Mancini GBJ, Yeoh E, Buller CE D, Keown PA, Mcmanus BM. Whole Blood 61, 2009. for the ACROSS/TOSCA-4 Investigators, Clinical Genomic Biomarkers of Acute Cardiac Allograft and Angiographic Outcomes with Sirolimus- Rejection. The Journal of Heart and Lung Lear, Dr. Scott A. Eluting Stents in Total Coronary Occlusions: Transplant. 2009, Vol. 28 NO. 09. The ACROSS/TOSCA-4 (Approaches to Chronic Barzi F, Woodward M, Czernichow S, Lee CM, Occlusions with Sirolimus-Eluting Stents/Total Maric B, Kaan A, Ignaszewski A, Lear SA. Kang JH, Janus E, Lear S, Patel A, Caterson I, Occlusion Study of Coronary Arteries-4) Trial, A systematic review of telemonitoring Patel J, Lam TH, Suriyawongpaisal P, Huxley JACC Intervention 2009;2:97-106. technologies in heart failure. Eur J Heart Fail R. The discrimination of dyslipidaemia using 2009;11:506-517. anthropometric measures in ethnically diverse Chow BJW, Larose E, Bilodeau S, Ellins ML, populations of the Asia Pacific Region: The Galiwango P, Kass M, Sheth T, Jasal DS, Kerr, Dr. Charles R. Obesity in Asia Collaboration. Obes Re. 2009 Jun Kirkpatrick IDC, Mancini GBJ, Mayo J, Abraham 2. [Epub ahead of print]. A, White J. The ‘what, when, where, who, and Benjamin EJ, Chen PS, Bild DE, Mascette AM, how?’ of Cardiac Computed Tomography in Albert CM, Alonso A, Calkins H, Connolly SJ, Lear SA, Kohli S, Bondy GP, Tchernof A, 2009: Guidelines for the Clinician, Can J Cardiol Curtis AB, Darbar D, Ellinor PT, Go AS, Sniderman A. Ethnic variation in fat and 2009, 25(3): 135-139. Goldschlager NF, Heckbert SR, Jalife J, Kerr CR, lean body mass and the association with Levy D, Lloyd-Jones DM, Massie BM, Nattel insulin resistance. J Clin Endocrinol Metab Hobbs FDR, Gensini G, Mancini GBJ, Manolis AJ, S, Olgin JE, Packer DL, Po SS, Tsang TS, Van 2009;94:4696-4702. Bauer B, Genest J, Feldman RD, Harvey P, Wagoner DR, Waldo AL, Wyse DG. Prevention of Jenssen TG, Marques da Silva P, for the JEWEL atrial fibrillation: report from a national heart, Lear SA, Araki Y, Maric B, Kaan A, Horvat D. Study Group. International open-label studies to lung, and blood institute workshop. Circulation . Prevalence and characteristics of home Internet assess the efficacy and safety of single-pill Volume: 119, Issue: 4, Date: 2009 Feb 3, Pages: access in patients with cardiovascular disease amlodipine/atorvastatin in attaining blood 606-18. from diverse geographic locations. Can J Cardiol pressure and lipid targets recommended 2009;25:589-593. by country-specific guidelines: the JEWEL Marcus FI, Zareba W, Calkins H, Towbin JA, Basso programme. Eur J Cardiovasc Prev Rehab 2009; C, Bluemke DA, Estes NA 3rd, Picard MH, Zimmerman AC, Lear SA, Holmes DT. Age 16(4); 472. Sanborn D, Thiene G, Wichter T, Cannom D, dependent reference intervals for measured Wilber DJ, Scheinman M, Duff H, Daubert bioavailable testosterone on the Siemens Advia Mancini GBJ, Bates E, Maron D, Hartigan P, Dada J, Talajic M, Krahn A, Sweeney M, Garan H, Centaur: Ethnicity specific values not necessary M, Gosselin G, Kostuk W, Sedlis S, Shaw L, Sakaguchi S, Lerman BB, Kerr C, Kron J, Steinberg for South Asians. Clin Biochem. 2009;42:922- Berman D, Berger P, Spertus J, Mavromatis JS, Sherrill D, Gear K, Brown M, Severski P, 925. K, Knudtson M, Chaitman B, O’Rourke R, Polonsky S, McNitt S. Arrhythmogenic right Weintraub W, Teo K, Boden W on behalf of the ventricular cardiomyopathy/dysplasia clinical Maric B, Kaan A, Ignaszewski A, Lear SA. COURAGE Trial Investigators and Coordinators, presentation and diagnostic evaluation: results A systematic review of telemonitoring Quantitative Results of Baseline Angiography from the North American Multidisciplinary technologies in heart failure. Eur J Heart Fail and Percutaneous Coronary Intervention in the Study Heart Rhythm. 2009 Jul;6(7):984-92. 2009;11:506-517. COURAGE Trial. Circ Cardiovasc Qual Outcomes. 2009;2:320-327. Khaykin Y, Wang X, Natal A, Wazni OM, Skanes Lear SA, Humphries KH, Hage-Moussa S, A, Humphries KH, Kerr CR, Morillo CA. Cost Chockalingam A, Mancini GBJ. Immigration Boden WE, O’Rourke RA, Teo KK, Maron DJ, Comparison Of Ablation Versus Antiarrhythmic presents a unique increased risk for Hartigan PM, Sedlis SP, Dada M, Labedi M, Drugs As First Line Therapy For Atrial Fibrillation: cardiovascular disease. Atherosclerosis Spertus JA, Kostuk WJ, Berman DS, Shaw LJ, An Economic Evaluation of the RAAFT Pilot 2009;205:584-589. Chaitman BR, Mancini GBJ, Weintraub WS on Study. J Cardiovasc Electrophysiol, 2009; 20: behalf of the COURAGE Trial Investigators, 7-12. Tillotson S, Lear S, Araki Y, Horvat D, Prkachin K, Impact of Optimal Medical Therapy With or Bates J, Balka E. Innovation in the North: are Without Percutaneous Coronary Intervention on Healey JS, Dorian D, Mitchell LB, Talajic M, health service providers ready for the uptake of Long-Term Cardiovascular End Points in Patients Philippon F, Simpson C, Yee R, Morillo CA, an internet-based chronic disease management with Stable Coronary Artery Disease (from the Lamy A, Basta M, Birnie DH, Wang X, Nair platform? Stud Health Technol Inform COURAGE Trial). Am J Cardiol 2009;104:1-4. GM, Crystal E, Kerr CR, Connolly SJ. Canadian 2009;143:472-477. Registry of ICD Implant Testing Procedures Lear SA, Humphries KH, Hage-Moussa S, (CREDIT): Current Practice, Risks, and Costs of Kohli S, Gao M, Lear SA. Using simple Chockalingam A, Mancini GBJ. Immigration Intraoperative Defibrillation Testing. J Cardiovasc anthropometric measures to predict body presents a potential increased risk for Electrophysiol: 2009; 21: 177-182. fat in South Asians. Appl Physiol Nutr Metab atherosclerosis. Atherosclerosis 205 (2009) 2009;34:40-48. 584–589. Dorian P, Guerra PG, Kerr CR, O’Donnell SS, Crystal E, Gillis AM, Mitchell LB, Roy D, Skanes Mancini, Dr. G. B. John Buller CE, Rankin JM, Carere RG, Buszman PE, AC, Rose MS, Wyse DG. Validation of a New Pfisterer ME, Dzavik V, Thomas B, Forman S, Simple Scale to Measure Symptoms in Atrial Malek LA, Reynolds H, Forman S, Vozzi C, Ruzyllo W, Mancini GBJ, Michalis LK, Abreu PF, Fibrillation: The Canadian Cardiovascular Society Mancini GBJ, French J, Dziarmaga M, Renkin J, Lamas GA, Hochman JS. Percutaneous coronary Severity in Atrial Fibrillation Scale. Circulation: Kochman J, Lamas G, Hochman J. Late coronary intervention in the Occluded Artery Trial: Arrhythmia and Electrophysiology, 2009: 2: intervention for totally occluded left anterior Procedural success, hazard, and outcomes over 218-224. descending coronary arteries in stable patients 5 years; Am Heart J 2009; 158-408-15. after myocardial infarction: Results fro the Kiess, Dr. Marla Occluded Artery Trial (OAT), Am Heart J 2009; Mohamed A, Andrade J, Ignaszewski A, Mancini 157:724-32. GBJ. Validity of carotid initima-media thickness Vitola JV, Shaw LJ, Allam AH, Orellana P, Peix as a surrogate endpoint for atherosclerosis: A, Ellmann A, Allman KC, Lee BN, Siritara C, Lessons from the ENHANCE trial; BC Medical Keng FY, Sambuceti G, Kiess MC, Giubbini R, Journal 2009; 51; 168-172. Bouyoucef SE, He ZX, Thomas GS, Mut F, Dondi

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Dzavík V, Buller CE, Devlin G, Carere RG, Mancini Johnson MA, Munt B, Moss RR. Determining considerations and complications. Can J Cardiol. GBJ, Cantor WJ, Buszman PE, Rankin JM, Vozzi Aortic Stenosis Severity – What to do When 2009 Aug;25(8):e273-8. C, Ross JR, Forman S, Barton BA, Lamas Measuring Left Ventricular Outflow Tract AG, Hochman JS. Angiographic and clinical Diameter is Difficult? JASE 2009. Saw J, Walsh SJ, Teal P, Starovoytov A, Fox outcomes of drug-eluting versus bare-metal R, Jokhi P, Fung AY. Carotid artery stenting stent deployment in the Occluded Artery Trial. Nasmith, Dr. James B. experience by interventional cardiologists in Catheter Cardiovasc Interv 2009, May 1 73(6), a Canadian cardiac catheterization laboratory. 780. Thao Huynh MD MSC, James Nasmith MD, The CJGIM 2009 Dec;4(4):242-5. Minh Luong MSC, Martin Bernier MD, Chantal Trial Investigators. Optimal medical therapy with Pharand ParmD, Zhao Xue-Qiao MD, Fung A, Saw J, Starovoytov A, Densem C, Jokhi P, or without percutaneous coronary intervention Robert Giugliano MD, Pierre Theroux MD. Walsh SJ, Fox RS, Humphries KH, Aymong E, in older patients with stable coronary disease: Complimentary prognostic values of ST segment Ricci DR, Webb JG, Hamburger J, Carere RG, a pre-specified subset analysis of the COURAGE deviation and Thrombolysis in Myocardial Buller CE. The BRIEF PCI (Brief infusion of (Clinical Outcomes Utilizing Revascularization Infarction (TIMI) risk score in non-ST elevation eptifibitide following following percutaneous and Aggressive druG Evaluation) trial. J Am acute coronary syndromes: Insights from coronary intervention) Randomized Trial. JACC College of Cardiol Sep 2009; 54(14):1303-8. the Platelet Receptor Inhibition in Ischemic 2009;53:837-45. Syndrome Management in Patients Limited by Genest J, McPherson R, Frohlich J, Anderson T, Unstable Signs and Symptoms (PRISM-PLUS) Virani, Dr. Shahnawaz (Sean) A. Campbell N, Carpentier A, Couture P, Dufour R, study. Can J Cardiology 2009;25(12):e417-21. Fodor G, Francis GA, Grover S, Gupta M, Hegele Haddad F., Fisher P., Pham M., Berry G., RA, Lau DC, Leiter L, Lewis GF. Lonn E. Mancini Rabkin, Dr. Simon W. Weisshaar D., Kuppahally S., Vrtovec B., Deuse GB. Ng D. Pearson GJ. Sniderman A. Stone JA. Ur T., Virani S., Fearon W., Valantine H. and Hunt E. 2009 Canadian Cardiovascular Rabkin SW, Klassen SS. Jumonji is a potential S. (2009) Right Ventricular Dysfunction Predicts Society/Canadian guidelines for the diagnosis Poor Outcome Following Hemodynamically and treatment of dyslipidemia and prevention regulatory factor mediating NO-induced modulation of cardiac hypertrophy. J of Compromising Rejection. The Journal of Heart of cardiovascular disease in the adult - 2009 and Lung Transplantation 28(4):312-319. recommendations; Canadian Journal of Cardiovascular Medicine 2009;10(2):206-11. Cardiology. October 2009; 25(10):567-79. Klassen SS, Rabkin SW. The metalloporphyrin Webb, Dr. John G. Maron DJ, Spertus JA, Mancini GB, Hartigan PM, FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen Webb JG. Strategies in the management of Sedlis SP, Bates ER, Kostuk WJ, Dada M, Berman coronary artery disease and transcatheter aortic DS, Shaw LJ, Chaitman BR, Teo KK, O’Rourke RA, peroxide on cardiomyocyte cell death. Arch Pharm 379: 149-155, 2009. valve implantation. Cathet Cardiovasc Interv Weintraub WS and Boden WE. COURAGE Trial 2009; 73: 68. Research Group. Impact of an initial strategy of medical therapy without percutaneous coronary Rabkin SW. The role of interleukin 18 in the pathogenesis of hypertension-induced vascular Wong DR, Boone RH, Thompson CR, Allard MF, intervention in high-risk patients from the Altwegg L, Carere RG, MD, Cheung A, Ye J, Clinical Outcomes Utilizing Revascularization disease. Nature cardiovascular Reviews 2009:6:192-199. Lichtenstein SV, Ling H, Webb JG. Mitral and Aggressive DruG Evaluation (COURAGE) valve injury after transcatheter aortic valve trial; Am J Cardiol October 2009; 104(8):1055- implantation. J Thorac Cardiovasc Surg 2009; 62. Rabkin SW. Apoptosis in Human Acute Myocardial Infarction: the Rationale for 137: 1547-9. Clinical Trials of Apoptosis Inhibition in Acute Moss, Dr. Robert R. Myocardial Infarction. Scholarly Research Webb JG, Altwegg L, Masson JB, Al Bugami S, Exchange, 2009. Al Ali A, Boone RA. A new transcatheter aortic Ye J, Cheung A, Lichtenstein S, Altwegg L, Wong valve and percutaneous valve delivery system. J DR, Carere RG,. Thompson CR, Moss RR, Munt Luong, MW, Rabkin SW Verapamil but not Am Coll Cardiol 2009; 53: 1855-8 B, Pasupati S, Boone RH, Masson JB, Ali AA, calpain or creatine alters arsenate-induced Webb JG. Transapical transcatheter aortic valve cardiac cell death. Toxicology & Industrial Health Fung AY, Saw J, Starovoytov A, Densem C, Jokhi implantation: 1-year outcome in 26 patients J. 2009;25(3):169-76. P, Walsh SH, Fox RS, Aymong E, Ricci RS, Webb Thorac. Cardiovasc. Surg., January 2009; 137: JG, Hamburger JN, Carere RG, Buller CE. 167 - 173. Tsang MYC, Rabkin SW, P38 MAPK is activated Abbreviated infusion of eptifibatide after by norepinephrine and serves a cardioprotective successful coronary intervention. The BRIEF-PCI Webb JG, Altwegg L, Boone R H, Anson Cheung role while epinephrine induces p38 MAPK trial. JACC Intervention 2009; 53: 837-45. A, Ye J, Samuel Lichtenstein S, Lee M, Masson dephosphorylation. Clin & Exp Physiol Pharm JB, Thompson C, Moss R, Carere R, Munt B, 2009;36:e12-19. Ye J, Cheung A, Lichtenstein SV, Altwegg LA, Nietlispach F, Humphries K. Transcatheter Aortic Wong DR, Carere RG, Thompson CR, Moss R, Valve Implantation: Impact on Clinical and Rabkin SW, Lodha P. Stearic acid-induced Munt B, Pasupati S, Boone RH, Masson JB, Valve-Related Outcomes. Circulation, Jun 2009; cardiac lipotoxicity is independent of cellular Al Ali A, Webb JG. Transapical transcatheter 119: 3009 - 3016. lipid and is mitigated by the fatty acids oleic and aortic valve implantation: 1-year outcome in capric but not by the PPAR agonist troglitazone. 26 patients. J Thorac Cardiovas Surg 2009; 137: Ye J, Webb JG, Cheung A, Masson JB, Carere RG, Experimental Physiology 2009;94:871-887. 167-173. Thompson CR, Munt B, Moss R, Lichtenstein SV. Transcatheter valve-in-valve implantation: Saw, Dr. Jacqueline W Jokhi PP, Walsh SJ, Saw J. Masson JB, Webb JG. Endovascular balloon 16-month follow-up. Ann Thorac Surg Successful percutaneous coronary intervention occlusion for catheter-induced large arterial 2009;88:1322-1324. of anomalous origin right coronary arteries with perforation in the catheterization laboratory. 3-D RCA guide catheters: a report of three cases. Cathet Cardiovasc Interv 2009; 73: 514-518. Wood DA, , Tops LF, Mayo JR, Pasupati S, Schalij Acute Card Care. 2009 May 18:1-4. MJ, Humphries K, Lee M, Ali AA. Munt B, Webb JG, Lukas Altwegg L, Boone RH, Cheung A, Moss R, Thompson CR, Bax JJ, Webb JG. Role of Jokhi PP, Ramanathan K, Walsh S, Fung AY, Saw J, Ye J, Lichtenstein L, Lee M, Carere R, Masson Multi-slice Computed Tomography in Fox RS, Zalunardo N, Buller CE. Experience of JB, Thompson C, Moss R, Munt B, Humphries Transcatheter Aortic Valve Replacement, AJC stenting for atherosclerotic renal artery stenosis K Transcatheter aortic valve replacement. Online 2009. in a cardiac catheterization laboratory: technical Impact on clinical and valve-related outcomes. Circulation 2009; 119:3009-3016.

7 | Annual Report 2009 Publication List

Leipsic J, Wood DA, Manders D, Nietlisbach F, COMMUNITY INTERNAL Dhingra, Dr. Vinay K. Masson JB, Mayo JR, Webb JG. The evolving role of multidetector computed tomography MEDICINE Simon Finfer, Dean R. Chittock, Steve Yu-Shuo in transcatheter aortic valve replacement: a Su, Deborah Blair, Denise Foster, Dhingra V, radiologist’s perspective. Am J Radiol 2009; 193: Jaffer, Dr. Shahin Rinaldo Bellomo, Deborah Cook, Peter Dodek, 214-9. William R. Henderson, Paul C. Hébert, Stephane P. Valensi, M. Benroubi, V. Borzi, J. Gumprecht, Heritier, Daren K. Heyland, Colin McArthur, Ellen Webb JG. Coronary obstruction due to R. Kawamori, J. Shaban, S. Shah, M. Shestakova, McDonald, Imogen Mitchell, John A. Myburgh, transcatheter valve implantation. Cathet Y. Wenying on behalf of the IMPROVETM Study Robyn Norton, Julie Potter, Bruce G. Robinson, Cardiovasc Interv 2009; 73; 973. Group Expert Panel. Initiating insulin therapy Juan J. Ronco. Intensive versus Conventional with, or switching existing insulin therapy to, Glucose Control in Critically Ill Patients, The Hamburger JN, Walsh SJ, Khurana R, Ding L, Tan biphasic insulin aspart 30/70 (NovoMix_ 30) in NICE-SUGAR Study Investigators. The New Z, Gao M, Humphries KH, Carere R, Fung AY, routine care: safety and effectiveness in patients England Journal of Medicine, 360(13): 1283- Mildenberger RR, Simkus GJ, Webb JG, Buller with type 2 diabetes in the IMPROVETM 1297, March 26, 2009. CEH. Percutaneous coronary intervention and observational study. J Clin Pract, March 2009, 30-day mortality: The British Columbia PCI Risk 63, 3, 522–531. Gorman SK, M Stewart LM, Slavik RS, de Lemos Score. Cathet Cardiovasc Interv 2009; 74: 377- J, Chittock D, Dhingra V, Ronco JJ, Parwana H. 85. Teoh H, Mendelsohn A, Goodman S, Jaffer S, et Identifying Missed Opportunities to Curtail al. Usefulness of Statin-Ezetimibe Combination Antimicrobial Therapy for Presumed Ventilator- Nietlispach F, LeipsicJB, Al-Bugamia S, Masson to Reduce the Care Gap in Dyslipidemia Associated Pneumonia using the Clinical JB, Carere RG, Webb JG. CT of the ilio-femoral Management in Patients with a High Risk of Pulmonary Infection Score. Can J Hosp Pharm arteries using direct aortic contrast injection: Atherosclerotic Disease. American Journal of 62(3): 217-225, May-June 2009. proof of feasibility in patients screened towards Cardiology, Sept 2009. percutaneous aortic valve replacement. Swiss Van den Berghe G., Bouillon R., Mesotten D., Med Wkly 2009; 139: 458-462. J. Gumprecht, M. Benroubi, V. Borzi, R. Braithwaite S. S., Pei J., Yi D., Khoo T. K., Olsen K. Kawamori, J. Shaban, S. Shah, M. Shestakova, A., Mohammedi K., Roussel R., Marre M., Hallas Ye J, Webb JG, Cheung A, Masson JB, Carere RG, Y. Wenying, R. Ligthelm, P. Valensi, on behalf P., Finfer S., Chittock D., the NICE-SUGAR Study Thompson CR, Munt B, Moss R, Lichtenstein S. of the IMPROVE TM. Intensification to biphasic Investigators Glucose Control in Critically Ill Transcatheter valve-in-valve implantation. insulin aspart 30/70 (BIAsp 30,NovoMix_R Patients. N Engl J Med 2009; 361:89-92, Jul 2, 16 month follow-up. Ann Thorac Surg. 30) can improve glycaemic control in patients 2009. 2009;88:1322-1324. treated with basal insulins: a subgroup analysis of the IMPROVE TM observational study. Henderson WR, Dhingra V, Chittock D, Foster D, Wong, Dr. Graham C. International Journal of Clinical Practice 2009 Hebert P, Cook D, Heyland D, Dodek P, Griesdale Jun;63(6):966-72. D, Schultzer M, Ronco JJ. The efficacy and Safety S. Jedrzkiewicz, SG Goodman, RT Yan, RC Welse, of Glucose Control algorithms in Intensive Care. J Kornder, JP DeYoung, GC Wong, B Rose, FR. S. Shah, M. Benroubi, V. Borzi, J. Gumprecht, Pol Arch Med Wewn. 119 (7-8): 439-444, 2009. Grondin, R Gallo, W Huang, JM Gore, AT Yan. R. Kawamori, J. Shaban, M. Shestakova, Temporal Trends in the Use of Invasive Cardiac Y. Wenying, P. Valensi, on behalf of the Dodek, Dr. Peter M. Procedures for Non-ST-Segment Elevation Acute IMPROVETM Study Group Expert Panel. Safety Coronary Syndromes According to Initial Risk and effectiveness of biphasic insulin aspart Lamarche Y, Cheung A, Walley K, Dodek P. Stratification. Can J Cardiol 2009; 25: e370-6. 30/70 (NovoMix_ 30) when switching from Combined use of extracorporeal membrane human premix insulin in patients with type 2 oxygenation and activated protein C for severe B. Elbarouni, SG Goodman, RT Yan, RC Welsh, diabetes: subgroup analysis from the 6-month ARDS and septic shock. Journal of Thoracic and JM Kornder, JP DeYoung, GC Wong, B Rose, FR IMPROVETM observational study. International J Cardiovascular Surgery, 2009; 138: 246-247. Grondin, R. Gallo, M. Tan, A. Casanova, KA Eagle Clin Pract 63:4,574-582, 2009. and AT Yan. Validation of the Global Registry of Heyland DK, Allan DE, Rocker G, Dodek P, Acute Coronary Event (GRACE) risk score for Pichora D, Gafni A. Discussing prognosis with in-hospital mortality in patients with acute patients and their families near the end of life: coronary syndrome in Canada. Am Heart J. CRITICAL CARE Impact on satisfaction with end of life care. 2009; 158: 392-9. Open Medicine. 2009; 3: 71-80. Chittock, Dr. Dean R. B Banihashemi, SG Goodman, RT Yan, RC Welsh, Bagshaw SM, Lapinsky S, Dial S, Arabi Y, Dodek P, SR Mehta, G. Montelescot, GC Wong, G Gyenes, Gorman SK, M Stewart LM, Slavik RS, de Lemos Wood G, Ellis P, Guzman J, Marshall J, Parrillo PG Steg and AT Yan. Underutilization of JE, Skrobik Y, Kumar A and the Cooperative clopidogrel and glycoprotein IIb/IIIa inhibitors in J, Chittock D, Dhingra V, Ronco JJ, Parwana H. Identifying Missed Opportunities to Curtail Antimicrobial Therapy of Septic Shock (CATSS) non-ST-elevation acute coronary syndrome Database Research Group. Acute Kidney Injury patients: the Canadian global registry of acute Antimicrobial Therapy for Presumed Ventilator- Associated Pneumonia using the Clinical in Septic Shock: Clinical Outcomes and Impact of coronary events (GRACE) experience. Am Heart Duration of Hypotension Prior to Initiation of J. 2009; 158: 917-924. Pulmonary Infection Score. Can J Hosp Pharm 62(3): 217-225, May-June 2009. Antimicrobial Therapy. Intensive Care Medicine 2009; 35: 871-881. JA Wong, SG Goodman, RT Yan, R. Wald, AJ Bagnall, RC Welsh, GC Wong, J. Kornder, Emergency Department driven Sepsis Protocol improves delivery of therapy in severely septic Mountain S, Dodek P, Hameed M, Ayas N, KA Eagle, PG Steg and AT Yan. Temporal Norena M, Chittock D, Wong H. The Effect of management patterns and outcomes of non-ST patient admitted in the Intensive Care Unit. Intensive Care Medicine. 2009. Ambient Workload in the Intensive Care Unit on elevation acute coronary syndromes in patients Mortality and Time to Discharge Alive from ICU. with kidney dysfunction. Eur Heart J. 2009; 30: Healthcare Quarterly 2009; 12: 8-14. 549-57. Dodek PM, Kozak J-F, Norena M, Wong H. More Men than Women are Admitted to 9 Intensive Care Units in British Columbia. Journal of Critical Care, 2009; 24: 630.e1-630.e8.

Publication List Annual Report 2009 | 8

Dodek PM. Review: Tight glucose control Henderson, Dr. William R. reduces risk for septicemia, but not death, and Kumar A, Zarychanski R, Pinto R, Cook DJ, increases hypoglycemia in critically ill adults. Henderson WR, Finfer S. Differences in outcome Marshall J, Lacroix J, Stelfox T, Bagshaw S, ACP Journal Club 2009; 150: JC1-5. between the NICE-SUGAR and Leuven trials: Choong K, Lamontagne F, Turgeon AF, Lapinsky possible methodological explanations. Crit Care S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja Strachan, P.H., Ross, H., Rocker, G.M., Resusc. 2009 Sep;11(3):175-7. K, McIntyre L, Menon K, Hutchison J, Hornstein Dodek, P.M., Heyland, D.K. for the Canadian D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Researchers at the End of Life Network Henderson WR, Dhingra V, Chittock D, Foster D, Olafson K, Ramsey C, Sharma S, Dodek P, Meade (CARENET). Mind the Gap: Opportunities for Hebert P, Cook D, Heyland D, Dodek P, Griesdale M, Hall R, Fowler RA; Canadian Critical Care Improving End-of-Life Care for Patients with D, Schulzer M, Ronco JJ; Canadian Critical Trials Trials Group H1N1 Collaborative. Critically ill Advanced Heart Failure. The Canadian Journal Group. The efficacy and safety of glucose control patients with 2009 Influenza A (H1N1) infection of Cardiology, 2009, 25: 635-640. algorithms in intensive care: a pilot study of the in Canada. JAMA. 2009 Nov 4;302(17):1872-9. Survival Using Glucose Algorithm Regulation The NICE-SUGAR Study Investigators. Intensive (SUGAR) trial. Pol Arch Med Wewn. 2009 Jul- MacRedmond, Dr. Ruth versus conventional glucose control in critically Aug;119(7-8):439-46. ill patients. N Engl J Med. 2009; 360: 1283-1297. MacRedmond R, Singhera GK, Dorscheid DR. The NICE-SUGAR Study Investigators. Intensive Erythropoietin inhibits Fas- and neutrophil- Wenner JB, Norena M, Khan N, Palepu A, Ayas versus conventional glucose control in critically mediated apoptosis of respiratory epithelium. NT, Wong H, Dodek PM. Reliability of ICU ill patients. N Engl J Med 2009;360:1283-97. Eur Respir J. 2009 Jun;33(6):1403-14. Admitting and Comorbid Diagnoses, Race, Elements of APACHE II Score, and Predicted Griesdale DEG, de Souza RJ, van Dam RM, Kelly E, MacRedmond R, Cullen G, Greene CM, Probability of Mortality in an Electronic ICU Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, McElvaney NG, O’ Neill SJ. The effect of age on Database. Journal of Critical Care. 2009; 24: Henderson WR, Chittock DR, Finfer S, Talmor D. systemic cytokine levels in Community Acquired 401-407. Intensive insulin therapy and mortality among Pneumonia. Respirology (2009) 14, 210-216. critically ill patients: a meta-analysis including Schroder C, Heyland D, Jiang X, Rocker G, Dodek NICE-SUGAR study data. CMAJ. 2009. 180:821 Peets, Dr. Adam D. P for the Canadian Researchers at the End of - 827. Life Network. Educating Medical Residents in Fraser K, Peets AD, Tworek J, Walker I, Wright B, End-of-Life Care: Insights from a Multicenter Keenan, Dr. Sean P. McLaughlin K. Simulator training can improve Survey. Journal of Palliative Medicine. 2009; 12: medical students’ acquisition and retention of 459-470. Burns KE, Meade MO, Lessard MR, Keenan SP, clinical skills. Med Educ, 2009;43:784-789. Lellouche F. Wean Earlier and Automatically Henderson W, Dhingra V, Chittock D, Foster D, with New technology (the WEAN study): a Peets AD, Coderre S, Wright B, Jenkins D, Burak Hebert P, Cook D, Heyland D, Dodek P, Griesdale protocol of a multicentre, pilot randomized K, Leskosky S, McLaughlin K. Involvement in D, Schulzer M, Ronco JJ in association with the controlled trial. Trials. 2009 Sep 4;10:81 teaching improves learning in medical students: Canadian Critical Care Trials Group. The Efficacy a randomized cross-over study. BMC Medical and Safety of Glucose Control Algorithms in Mehta S, Al-Hashim AK, Keenan SP. Noninvasive Education 2009;9:55. Intensive Care: A Pilot Study of the Survival positive pressure ventilation in patients with Using Glucose Algorithm Regulation (SUGAR) acute cardiogenic pulmonary edema. Resp Care Billington EO, Zygun D, Stelfox HT, Peets Trial. Pol Arch Med Wewn. 2009; 119 (7-8): 2009, Feb;54(2):186-97. AD. Intensivists’ base specialty of training is 439-446. associated with variations in mortality and Keenan SP, Mehta S. Noninvasive positive practice patterns. Critical Care 2009;13:R209. Kumar A, Zarychanski R, Pinto R, Cook DJ, pressure ventilation for patients presenting Marshall J, Lacroix J, Stelfox T, Bagshaw S, with acute respiratory failure: the randomized Ronco, Dr. Juan J. Choong K, Lamontagne F, Turgeon AF, Lapinsky controlled trials. Resp Care 2009, Jan;54(1):116- S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja 26. K, McIntyre L, Menon K, Hutchison J, Hornstein The NICE SUGAR Investigators. Intensive vs. D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Conventional Glucose Control in Critically Ill Martin CM, Priestap F, Fisher H, Fowler RA, Patients. New Engl J Med 2009; 360:1283-1297. Olafson K, Ramsey C, Sharma S, Dodek P, Meade Heyland DK, Keenan SP, Longo C, Morrison T, M, Hall R, Fowler R for the Canadian Critical Bentley D, Antman N. Outcomes, prevalence Henderson, WR, Dhingra V, Chittock DR, Foster Care Trials Group H1N1 Collaborative. Critically and incidence for patients with severe sepsis ill patients with 2009 influenza A (H1N1) D, Hebert P, Cook D, Heyland D, Dodek PM, in a prospective, observational registry: The Griesdale D, Schulzer M, Ronco JJ. The Efficacy infection in Canada. JAMA, 2009; 302:1872- Canadian Sepsis Treatment and Response (STAR) 1879. and Safety of Glucose Control Algorithms in Registry. Crit Care Med 2009 Jan;37(1):81-8. Intensive Care: A Pilot Study of the Survival Using Glucose Algorithm Regulation (SUGAR) Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Burns KEA, Adhikari NKJ, Keenan SP, Meade Parillo JE, Dodek P, Wood G, Kumar A, Simon D, Trial. Polskie Archiwum Medycyny Wewnêtrznej M. Noninvasive ventilation to wean critically ill 2009; 119 (7-8):439-446. Peters C, Ahsan M, Chateau D, and the adults from invasive mechanical ventilation: a Cooperative Antimicrobial Therapy of Septic meta-analysis update. BMJ 2009;338:b1574 Shock Database Research Group. Initiation of Russell, Dr. James A. inappropriate antimicrobial therapy results in Azoulay E, Timsit JF, Sprung CL, et al. for the a fivefold reduction of survival of human septic Conflicus Study Investigators. Prevalence and Russell JA. Vasopressin and its copilot copeptin shock. Chest. 2009; 136: 1237-1248. factors of Intensive Care Unit conflicts: The in sepsis and septic shock. Crit Care Med 37(2): Conflicus Study. Am J Respir Crit Care Med 749 – 750, 2009. Dorscheid, Dr. Delbert R. 2009;180:853-860. Shaw DM, Sutherland AM, Russell JA, MacRedmond R, Singhera GK, Dorscheid DR. Kesecioglu J, Beale R, Stewart TE, et al. for the Lichtenstein SV, Walley KR. Novel polymorphism Erythropoietin inhibits respiratory epithelial cell HL10 INT Study Group. Exogenous natural of interleukin-18 associated with greater apoptosis in a model of ALI. Eur Respir J. surfactant for treatment of acute lung injury and inflammation after cardiac surgery. Crit Care 33(6):1403-1414, 2009. the acute respiratory distress syndrome. Am J 29;13(1):R9, 2009. Respir Crit Care Med 2009; 180:989-994.

9 | Annual Report 2009 Publication List

Russell JA, Walley KR, Singer J, Gordon AC, Nakada E, Walley KR, Nakada T, Hu Y, von Simonelli C, Adler RA, Blake GM, Caudill JP, Khan Hébert PC, Cooper DJ, Holmes CL, Mehta S, Dadelszen P, Boyd JH. Toll-like receptor-3 A, Leib E, Maricic M, Prior JC, Eis SR, Rosen C, Granton JT, Storms MM, Cook DJ, Presneill JJ, stimulation upregulates sFLT-1 production by Kendler DL. Dual-Energy X-Ray Absorptiometry Ayers D for the VASST investigators. Interaction trophoblast cells. Placenta. Jul 23 [Epub ahead Technical issues: the 2007 ISCD Official of vasopressin infusion, corticosteroid treatment of print] PMID 19631980, 2009. Positions. J Clin Densitom. 2008 Jan- and mortality of septic shock. Crit Care Med Mar;11(1):109-22. 37(3):811-818, 2009. Gordon AC, Russell JA, Walley KR, Singer J, Ayers D, Storms MM, Holmes CL, Hébert PC, Cooper Baim S, Binkley N, Bilezikian JP, Kendler DL, Hans Hodder RV, Hall R, Russell JA, Fisher HN, DJ, Mehta S, Granton JT, Cook DJ, Presneill JJ, for DB, Lewiecki EM, Silverman S. Official Positions Lee B. Early drotrecogin alpha (activated) the Vasopressin and Septic Shock Trial (VASST) of the International Society for Clinical administration in severe sepsis is associated Investigators. The effects of vasopressin on Densitometry and executive summary of the with lower mortality: a retrospective analysis acute kidney injury in septic shock. Intensive 2007 ISCD Position Development Conference. J of the Canadian ENHANCE cohort. Crit Care. Care Med. [Epub ahead of print] PMID Clin Densitom. 2008 Jan-Mar;11(1):75-91. 13(3):R78, 2009. 19841897, 2009. Chen P, Miller PD, Binkley NC, Kendler DL, Wong Tsang, Dr. John Y. Nakada TA, Russell JA, Boyd JH, Aguirre- M, Krohn K. Use of lowest single lumbar spine Hernandez R, Thain KR, Thair SA, Nakada E, vertebra bone mineral density T-score and other Tsang JY, Lamm WJE, Swenson ER. Regioinal CO2 McConechy M, Walley KR. ß2-Adrenergic T-score approaches for diagnosing osteoporosis tension quantitatively mediates homeostatic receptor gene polymorphism is associated and relationships with vertebral fracture status. redistribution of ventilation following acute with mortality in septic shock. Am J Respir Crit J Clin Densitom. 2008 Oct-Dec;11(4):525-31 pulmonary thromboembolism in pigs. J Appl Care Med. Oct 22 [Epub ahead of print] PMID Physiol 2009; 107: 755-762. 19850944, 2009. Khan AA, Sándor GK, Dore E, Morrison AD, Alsahli M, Amin F, Peters E, Hanley DA, Chaudry Walley, Dr. Keith R. SR, Lentle B, Dempster DW, Glorieux FH, Neville ENDOCRINOLOGY AJ, Talwar RM, Clokie CM, Mardini MA, Paul T, Lamarche Y, Cheung A, Walley KR, Dodek PD. Khosla S, Josse RG, Sutherland S, Lam DK, Combined use of extracorporeal membrane Finegood, Dr. Diane T. Carmichael RP, Blanas N, Kendler D, Petak S, oxygenation and activated protein C for severe Ste-Marie LG, Brown J, Evans AW, Rios L, Compston JE; Canadian Taskforce on ARDS and septic shock. J Thoracic Cardiovasc Malhi, L., Karanfil, Ö., Merth, T., Acheson, M., Surg. 138(1):246-247, 2009. Osteonecrosis of the Jaw. Bisphosphonate Palmer, A., Finegood, D.T. Places to Intervene to associated osteonecrosis of the jaw. J Make Complex Food Systems More Healthy, Rheumatol. 2009 Mar;36(3):478-90. Russell JA, Walley KR, Gordon AC, Cooper Green, Fair, and Affordable. J Hunger and DJ, Hébert PC, Singer J, Holmes CL, Mehta S, Environmental Nutrition, 4 (3 & 4): 466- 476, Kendler DL, Adachi JD, Josse RG, Slosman Granton JT, Storms MM, Cook DJ, Presneill JJ, 2009. Ayers D for the Vasopressin and Septic Shock DO. Monitoring strontium ranelate therapy in Trial (VASST) Investigators. Interaction of patients with osteoporosis. Osteoporos Int. Atkinson, L.L., Topp, B.G., Au, J., Vinerian, H.V., 2009 Jul;20(7):1101-6. vasopressin infusion, corticosteroid treatment Dhatt, N., Finegood, D.T. Quantification of the and mortality of septic shock. Crit Care Med. Relationship between Glycemia and Beta 37(3):811-8, 2009. Leslie WD, O’Donnell S, Jean S, Lagacé C, Walsh Cell Mass Adaptation in vivo. Can J Physiol P, Bancej C, Morin S, Hanley DA, Papaioannou A; Pharmacol 87: 602-9, 2009. Shaw DM, Sutherland AM, Russell JA, Osteoporosis Surveillance Expert Working Lichtenstein SV, Walley KR. Novel polymorphism Group. Trends in hip fracture rates in Canada. Bauman, A. Finegood, D.T., Matsudo, M. JAMA. 2009 Aug 26;302(8):883-9. of interleukin-18 associated with greater International Perspectives on the Physical inflammation after cardiac surgery. Critical Care Inactivity Crisis – Structural Solutions Over 13(1):R9, 2009. Cummings SR, San Martin J, McClung MR, Siris Evidence Generation? Preventive Medicine 49: ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin 309-12, 2009. Murkin JM, Walley KR. Genetic susceptibility M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; to inflammatory injury and various adverse Kendler, Dr. David L. outcomes. J Extra Corpor Technol. 41(1):43-9, FREEDOM Trial. Denosumab for prevention 2009. of fractures in postmenopausal women Kendler DL, Roux C, Benhamou CL, Brown with osteoporosis. N Engl J Med. 2009 Aug JP, Lillestol M, Siddhanti S, Man HS, San Boyd JH, Walley KR. The role of 20;361(8):756-65. Epub 2009 Aug 11. Erratum Martin J, Bone HG. Effects of Denosumab on in: N Engl J Med. 2009 Nov 5;361(19):1914. echocardiography in hemodynamic monitoring. Bone Mineral Density and Bone Turnover in Curr Opin Crit Care, 15(3):239-43, 2009. Postmenopausal Women Transitioning from Kendler DL, Bessette L, Hill CD, Gold DT, Horne Alendronate Therapy. J Bone Miner Res. 2009 R, Varon SF, Borenstein J, Wang H, Man HS, Sutherland AM, Walley KR. Bench-to-Bedside Jul 13. Review: Association of Genetic Variation with Wagman RB, Siddhanti S, Macarios D, Bone HG. Sepsis. Critical Care. 13:210, 2009. Preference and satisfaction with a 6-month Khan AA, Colquhoun A, Hanley DA, Jankowski subcutaneous injection versus a weekly tablet LG, Josse RG, Kendler DL, Lentle B, Leslie WD, Indrambarya T, Boyd JH, Wang Y, McConechy M, for treatment of low bone mass. Osteoporos Lewiecki EM, O’neill E, Robertson S, Syed ZA, Int. 2009 Aug 6. Walley KR. Low-dose vasopressin infusion Tanner SB, Webster D. Standards and guidelines results in increased mortality and cardiac for technologists performing central dual-energy Eastell R, Black DM, Boonen S, Adami S, dysfunction following ischemia-reperfusion X-ray absorptiometry. J Clin Densitom. 2007 injury in mice. Crit Care 13(3):R98, 2009. Felsenberg D, Lippuner K, Cummings SR, Apr-Jun;10(2):189-95. Epub 2007 Feb 28. Delmas PD, Palermo L, Mesenbrink P, Cauley Holmes CL, Walley KR. Vasoactive drugs for JA; HORIZON Pivotal Fracture Trial. Effect of Blake GM, Lewiecki EM, Kendler DL, Fogelman I. once-yearly zoledronic acid five milligrams on vasodilatory shock in ICU. Curr Opin Crit Care. A review of strontium ranelate and its effect on 15: 398-402, 2009. fracture risk and change in femoral neck bone DXA scans. J Clin Densitom. 2007 Apr- mineral density. J Clin Endocrinol Metab. 2009 Jun;10(2):113-9. Epub 2007 Feb 28. Review. Sep;94(9):3215-25.

Publication List Annual Report 2009 | 10

Delmas PD, Munoz F, Black DM, Cosman F, Study Group. The impact of incident fractures Thompson, Dr. David M. Boonen S, Watts NB, Kendler D, Eriksen EF, on health-related quality of life: 5 years of data Mesenbrink PG, Eastell R; HORIZON-PFT from the Canadian Multicentre Osteoporosis Klimek AM, Soukhatcheva G, Thompson DM, Research Group. Effects of yearly zoledronic Study. Osteoporosis International 2009, 20:703- Warnock GL, Salehi M, Rilo H, D’Alessio D, acid 5 mg on bone turnover markers and 714. Meneilly GS, Panagiotopoulos C, Verchere CB. relation of PINP with fracture reduction in Impaired proinsulin processing is a characteristic postmenopausal women with osteoporosis. J Chen P., Krege J.H., Adachi J.D., Prior J.C., of transplanted islets. Am J Transplantation Bone Miner Res. 2009 Sep;24(9):1544-51. Tenenhouse A., Brown J.P., Papadimitropoulos 2009;9:2119-2125. M., Kreiger N., Olszynski W.P., Josse R.G., Eastell R, Lang T, Boonen S, Cummings S, Delmas Goltzman D., Vertebral Fracture Status and the Johnson JD, Ao Z, Ao P, Li H, Dia L, He Z, Tee M, PD, Cauley JA, Horowitz Z, Kerzberg E, Bianchi World Health Organization (WHO)Risk Factors Potter KJ, Klimek AM, Meloche RM, Thompson G, Kendler D, Leung P, Man Z, Mesenbrink P, for Predicting Osteoporotic Fracture Risk. DM, Verchere CB, Warnock GL. Different effects Eriksen EF, Black DM; for the HORIZON Pivotal Journal of Bone Mineral Research, 2009, 24(3): of FK506, rapamycin and mycophenolate mofetil Fracture Trial. Effect of once-yearly zoledronic 495-502. on glucose-stimulated insulin release and acid on the spine and hip as measured by apoptosis in human islets. Cell Transplantation quantitative computed tomography: results of Berger, C., Langsetmo, L., Joseph, L., Hanley, 2009;18:833-45. the HORIZON Pivotal Fracture Trial. Osteoporos D.A., Davison, S.K., Josse, R.G., Prior, J.C., Int. 2009 Oct 3. Krieger, N., Tenenhouse, A., Goltzman, D., and Tham E, Liu J, Innis S, Thompson DM, Gaylinn the CaMos Research Group (2009). Association B, Bogarin R, Haim A, Thorner M, Chanoine J-P. Leslie WD, O’Donnell S, Lagacé C, Walsh P, Between Change in BMD and Fragility Fracture Acylated ghrelin concentrations are markedly Bancej C, Jean S, Siminoski K, Kaiser S, Kendler in Women and Men. JBMR, 24(2): 361-371. decreased during pregnancy in mothers with DL, Jaglal S; For the Osteoporosis Surveillance and without gestational diabetes: relationship Expert Working Group. Population-based Harvey A.T., Hitchcock C.L., Prior J.C. (2009). with cholinesterase. Am J Physiol EM Canadian hip fracture rates with international Ovulation disturbances and mood across the 2009;296:E1093-E1100. comparisons. Osteoporos Int. 2009 Oct 3. menstrual cycles of healthy women. Journal of Psychosomatic Obstetrics and Gynecology, Tildesley, Dr. Hugh D. Elefteriou F, Kolanczyk M, Schindeler A, Viskochil 30(4), 207-214. DH, Hock JM, Schorry EK, Crawford AH, Yung K, Aydin C, Mazanderani A, Johnson M, Friedman JM, Little D, Peltonen J, Carey JC, Ioannidis G., Papaioannou A., Hopman W.M., Chui L, Tildesley H. Marfan Syndrome and Early Feldman D, Yu X, Armstrong L, Birch P, Kendler Akhatar-Danesh N., Anastassiades T., Pickard L., Onset Diabetic Retinopathy - Case Report. DL, Mundlos S, Yang FC, Agiostratidou G, Kennedy C.C., Prior J.C., Olszynski W.P., Davison International Journal of Endocrinology and Hunter-Schaedle K, Stevenson DA. Skeletal K.S., Goltzman D., Thabane L., Gafni A., Metabolism, 2009; 1: 41-45. abnormalities in neurofibromatosis type 1: Papadimitriopoulos E.A., Brown J.P., Josse R.G., approaches to therapeutic options. Am J Med Hanley D.A., Adachi J.D.(2009) Relationship Mazanderani A, Wise S., Tildesley H. Genet A. 2009 Oct;149A(10):2327-38. between fractures and mortality: results from Apolipoprotein B Levels in Adults with Type 1 the Canadian Multicentre Osteoporosis Study. Diabetes Not Receiving Lipid-Lowering Therapy. Kendler DL, Ringe JD, Ste-Marie LG, Vrijens Canadian Medical Association Journal, 181: Clinical Biochemistry 2009;42(12):1218-1221. B, Taylor EB, Delmas PD. Risedronate dosing 265-271. before breakfast compared with dosing later Tildesley H, Fraser T, Wise S, Mazanderani A, in the day in women with postmenopausal Bedford J.L., Prior J.C., Hitchcock C.L., & Barr S.I. Aydin C, Johns K, Yu E, Bondy G. Low Prevalence osteoporosis. Osteoporos Int. 2009 (2009). Detecting evidence of luteal activity by of Elevated apoB levels in Type 2 Diabetes not Nov;20(11):1895-902. least-squares quantitative basal temperature receiving Lipid-Lowering therapy. Canadian analysis against urinary progesterone Journal of Diabetes 2009;33: 163-169. Davison KS, Kendler DL, Ammann P, Bauer DC, metabolites and the effect of wake-time Dempster DW, Dian L, Hanley DA, Harris ST, variability. European Journal of Obstetrics and McClung MR, Olszynski WP, Yuen CK. Assessing Gynecology and Reproductive Biology, 146:76- fracture risk and effects of osteoporosis drugs: 80. GASTROENTEROLGY bone mineral density and beyond. Am J Med. 2009 Nov;122(11):992-7. Langsetmo L., Goltzman D., Kovacs C.S., Adachi Bressler, Dr. Brian J.D., Hanley D.A., Kreiger N., Josse R., Van Tongeren LS, Duncan GG, Kendler DL, Pai H. Papaionnou A., Olszynski W.P., Jamal SA., Segal B, Lam E, Amar J, Bressler B, Halparin L, Implementation of osteoporosis screening CaMOS Research Group. Repeat low-trauma Ramji A, Telford J, Whittaker S, Enns R. Add-on guidelines in prostate cancer patients on fractures occur frequently among men and cases in the endoscopy unit: Factors that androgen ablation. J Clin Densitom. 2009 women who have osteopenic BMD. (2009) affect volume. Can J Gastroenterol. 2009 Jul-Sep;12(3):287-91. Journal of Bone and Mineral Research, (9):1515- Jul;23(7):485-8. 22. Prior, Dr. Jerilynn C. Ko HH, Jamieson T, Bressler B.Acute pancreatitis Jamal S.A., Swan V.J., Brown J.P., Hanley D.A., and ileus post colonoscopy. Can J Gastroenterol. Langsetmo L.A, Morin, S., Richards, J.B., Prior J.C., Papaioannou A., Langsetmo L., Josse 2009 Aug;23(8):551-3. Davison, K.S., Olszynski W.P, Prior, J.C., Josse, R., R.G., Canadian Multicentre Osteoporosis Study Goltzman, D., & CaMos Research Group Research Group. (2009) Kidney Function and Schneeweiss S, Korzenik J, Solomon DH, Canning (2009). Effectiveness of antiresorptives for Rate of Bone Loss at the Hip and Spine: The C, Lee J, Bressler B. Infliximab and other the prevention of non-vertebral low-trauma Canadian Multicentre Osteoporosis Study. immunomodulating drugs in patients with fractures in a population-based cohort of American Journal of Kidney Function, 55(2) inflammatory bowel disease and the risk of women. Osteoporosis International, 291-299. serious bacterial infections. Aliment Pharmacol 20:283–290. Ther 2009 Aug;30(3):253-64.

Papaioannou A, Kennedy C.C., Ioanidis G., Sawka Krygrier DS, Ko HH, Bressler, B. How to manage A., Hopman W.M., Pickard L., Brown J.P., Josse difficult Crohn’s disese: optimum delivery of R.G., Kaiser S., Anastassiades T., Goltzman D., anti-TNFs. Expert Rev Gastroenterol Hepatol Papadimirtopoulous M., Tenenhouse A., Prior 2009 Aug;3:307-15. J.C., Olszynski W.P., Adachi J.D., for the CaMos

11 | Annual Report 2009 Publication List

Brian Bressler, Ka Wang, Joseph F. Grippo, Coss A, Enns R. The investigation of unexplained Fishman, Dr. Martin J. E. Jenny Heathcote. Pharmacokinetics and biliary dilation. Current Gastroenterology response of obese patients with chronic Reports 2009;11(2):155-159. Love J, Bernard EJ, Cockeram A, Cohen L, hepatitis C treated with different doses of PEG- Fishman M, Gray J, Morgan D. A multicentre IFN -2a (40KD) (PEGASYS®). British Journal of Ko Hin Hin, Enns R. Factors influencing patient observational study of sodium picosulfate and Clinical Pharmacology 2009;(67)3:280-287. satisfaction in patients undergoing endoscopic magnesium citrate as precolonoscopy bowel procedures. Gastrointestinal Endoscopy 2009; preparation. Can J Gastroenterol 2009 Oct 23 Byrne, Dr. Michael F. 69: 883-891. 10): 706-10. Byrne MF, McLoughlin MT, Mitchell RM, Gerke Wong V, Zhang HB and Enns R. Factors Freeman, Dr. Hugh J. H, Kim K, Pappas TN, Branch MS, Jowell PS, associated with patients absenteeism for Baillie J. For patients with predicted low risk for scheduled endoscopy. World J of Gastroenterol Freeman HJ. Relevance of segmental colitis choledocholithiasis undergoing laparoscopic 2009;15(23): 2882-2886. with diverticulosis (SCAD) to other forms cholecystectomy, selective intraoperative of inflammatory bowel disease. Can J cholangiography and postoperative endoscopic Segal B, Lam E, Amar J, Bressler B, Halparin L, Gastroenterol 2009; 23: 439-440. retrograde cholangiopancreatography is Ramji A, Telford J, Whittaker S, Enns R. Add on an effective strategy to limit unnecessary cases in the endoscopy unit, factors that affect Freeman HJ, Webber DL, Meneghetti AT. An procedures. Surg Endosc. 2009 Sep;23(9):1933- volume. CJG 2009;23(7): 485-8. appendiceal neoplastic lesion. A case report and 7. implications for colonoscopic screening and Lee M, Enns R. Narrow Band Imaging In surveillance. Can J Gastroenterol 2009; 23: Lynd LD, Najafzadeh M, Colley L, Byrne MF, Gastroesophageal reflux and Barrett’s 379-381. Willan AR, Sculpher MJ, Johnson FR, Hauber AB. esophagus. Can J Gastroenterol 2009;23(2):84- Using an incremental net-benefit framework for 7. Freeman HJ. Longstanding eosinophilic quantitative benefit-risk analysis in regulatory gastroenteritis over 20 years. Can J decision making - a case study of alosetron in Poynard T, Colombo M, Bruix J, Schiff E, Terg R, Gastroenterol 2009; 23: 632-634. irritable bowel syndrome. Value Health. 2009 Flamm S, Moreno-Otero R, Carrilho F, Schmidt Sep 10. W, Berg T, McGarrity T, Heathcote EJ, Gonçales F, Freeman HJ. Malignancy in adult celiac disease. Diago M, Craxi A, Silva M, Bedossa P, World J Gastroenterol 2009; 15: 1581-1583. Byrne MF, McLoughlin MT, Mitchell RM, Mukhopadhyay P, Griffel L, Burroughs M, Brass Gerke H, Pappas TN, Branch MS, Jowell PS, C, Albrecht J; Epic Study Group. Peginterferon Freeman HJ. Selected luminal complications Baillie J. The fate of patients who undergo alfa-2b and ribavirin: effective in patients of adult celiac disease. Clin Exp Gastroenterol “preoperative” ERCP to clear known or with hepatitis C who failed interferon alfa/ 2009; 2: 9-12. suspected bile duct stones. Surg Endosc. 2009; ribavirin therapy. Gastroenterology. 2009 23 (1): 74-9. May;136(5):1618-28. Freeman HJ. Long-term natural history of Crohn’s disease. World J Gastroenterol 2009; 15: Coss A, Byrne MF. Preoperative biliary J-F Colombel, D A Schwartz, W J Sandborn, M A 1315-1318. drainage in malignant obstruction: indications, Kamm, G D’Haens, P Rutgeerts, R Enns, R techniques, and the debate over risk. Curr Panaccione, S Schreiber, J Li, J D Kent, K G Freeman HJ, Gillett HR, Gillett PM, Oger J. Adult Gastroenterol Rep. 2009 Apr;11(2):145-9. Lomax, P F Pollack. Adalimumab for the celiac disease with acetylcholine receptor treatment of fistulas in patients with Crohn’s antibody positive myasthenia gravis. World J Al Ali J, Monk P, Byrne MF. Pancreatic disease. Gut 2009 Jul; 58(7): 940-8. Gastroenterol 2009; 15: 4741-4744. pseudocyst with fistula to the common bile duct resolved by combined biliary and pancreatic JK Law1, MD; CN Andrews2, MD; R Enns3, Freeman HJ. Adult celiac disease and its stenting-A case report and literature review. MD Intravenous Proton Pump Inhibition malignant complications. Gut and Liver, 2009 Canadian Journal of Gastroenterology 2009 Utilization and Prescribing Patterns Escalation: A Dec, 3(4): 237-246. Aug;23(8):557-9. Comparison Between Early and Present Trends in Use. Gastrointestinal Endoscopy 2009 Jan; Freeman HJ. Tropheryma whipplei infection. Chatur, Dr. Nazira 69(1): 3-9. World J Gastroenterol 2009; 15: 2078-2080.

Chang A, Krygier DS, Chatur N, Yoshida, EM. Enns R., Bressler, B. Current Endoscopic Freeman HJ. Collagenous sprue: a distinctive Clozapine-induced fatal fulminant hepatic Practices: The Experts Speak – Dysplasia and and heterogeneous clinicopathologic disorder. failure: A Case Report. Can J Gastroenterol 2009; colitis. Can J Gastroenterol. 2009 May; 23(5): Gastroenterol & Hepatol 2009; 5: 425-426. 23(5): 376-8. 345-347. Freeman HJ, Webber DL. Free perforation in Enns, Dr. Robert A. Sadowski DC, Bernstein CN, Bitton A, Croitoru collagenous sprue. World J Gastroenterol 2009; K,Fedorak RN, Griffiths A, and the CAG Crohn’s 15: 4446-4448. Consensus Group (R Enns - Panel Member). J. Law, C Andrews, R. Enns. Intravenous proton Canadian Association of Gastroenterology Freeman HJ. Multifocal ulcerating stenoses of pump inhibition utilization and prescribing Clinical Practice Guidelines: The use of tumour patterns escalation: a comparison between the small intestine. World J Gastroenterol 2009; necrosis factor-alpha antagonist therapy in 15: 4883-4885. early and current trends in use. Gastrointestinal Crohn’s disease. March 2009 23(3),185-202. Endoscopy 2009;69(1):3 – 9. Freeman HJ, Berean K. Lethal neuroendocrine Colombel JF, Schwartz DA, Sandborn WJ, Kamm Lee M, Enns R. Narrow Band Imaging for the carcinoma in ulcerative colitis. World J MA, D’Haens G, Rutgeerts P, Enns R, Panaccione Gastroenterol 2009; 15: 5882-5883. Detection of Neoplastic Lesions of the Colon. R, Schreiber S, Li J, Kent J, Lomax KG, Pollack Can J Gastroenterol 2009;23(1):15-18. P. Adalimumab for the treatment of fistulas in patients with Crohn’s disease. Gut 2009;58:940- Gray, Dr. James R. Rosta A, Hunt R. CAG Canadian Consensus 948. Guidelines on long-term nsaid therapy and Skinner BJ, Gray JR, Attara G. Increased health the need for gastroprotection (Voting panel costs from mandated Therapeutic Substitution member). Aliment Pharmacol Ther. 2009 Mar of proton pump inhibitors in British Columbia. 1;29(5):481-96. Aliment Pharmacol Ther 2009; 29: 882-891.

Publication List Annual Report 2009 | 12

Gray JR, Leung E, Scales J. Treatment of I.S. H. Cadden, E.D. Greanya, S. R. Erb, C.H. Krygier, DS., Steingbrecher, UP., Petric, M., Erb, ulcerative colitis from the patient’s perspective: Scudamore, E.M. Yoshida. The Use of Sildenafil SR., Chung, SW., Buzchowski, AK. Parvovirus a survey of preferences and satisfaction with to Treat Portopulmonary Hypertension Prior B19 induced hepatic failure in an adult requiring therapy. Aliment Pharmacol Ther 2009; 29: to Liver Transplantation. Annals of Hepatology liver transplantation. World J Gastroenterol 1114-1120. 2009; 8: 158-61. 2009; 15(32): 4067-4069

Salh, Dr. Baljinder Singh DF Schaeffer, EM Yoshida , AL Buczkowski, Haque, M., Schumacher, PA., Harris, A., SR Erb, , UP Steinbrecher, SW Chung, CH Scudamore, CH., Steinbrecher, UP., Chung, SW., Law J, Salh B and Yoshida E. All that bleeds is not Scudamore. Surgical Morbidity in Severely Buczkowshi, AK., Erb, SR., Yoshida, EM. Late ulcerative colitis. Can J Gastroenterol 23:91-2, Obese Liver Transplant Recipients: A Single Acute Celiac and Hepatic Artery Thrombosis 2009. Centre Experience. Annals of Hepatology 2009; with Portal Vein Thrombosis Resulting in 8: 38-40. Hepatic Infaction 12 years Post-Orthotopic Liver Tai, Dr. Isabella T. Transplantation. Annals of Hepatology 2009; 8: Albert Chang, Darin S. Krygier, Nazira Chatur, 396-99. Chung C, Ali JA, Owen DA, Weiss AA, Yoshida Eric M. Yoshida. Clozapine-Induced Fulminant EM, Tai IT. A Rare Case of Isolated Duodenal Hepatic Failure: A Case Report. Canadian Journal Chung, C. Ali, JA., Owen, D., Weiss, A., Yoshida, Metastases from Hepatocellular Carcinoma of Gastroenterology 2009; 23: 376-78. E., Tai, I. A Rare Case of Isolated Duodenal Assoiated with p53 and Ki-67 Expression. Cases Metastases from Hepatocellular Carcinoma J. 2009 Dec 17;2:9344. J.K. Law, B. Salh, E.M. Yoshida. All that Bleeds is Associated with p53 and ki67 Expression: a Case not Infliximab-refractory Ulcerative Colitis. Report. Cases Journal 2009; 2: 9344 (www. Canadian Journal of Gastroenterology 2009; 23: casesjournal.com). Telford, Dr. Jennifer J. 91-92. Ko H, Zhang H, Telford JJ, Enns R. Patient Keyur Patel, Yves Benhamou, Eric M. GENERAL INTERNAL Satisfaction with Endoscopy Is Influenced By Yoshida, Kelly D. Kaita, Stefan Zeuzem, the Timing of the Survey. Gastrointestinal Michael Torbensen, Erik Pulkstenis, G. Mani MEDICINE Endoscopy 2009;69:883-91. Subramanian, John G. McHutchison. An Independent and Prospective Comparison Baillie, Dr. Hector M. Segal B, Lam E, Amar J, Bressler B, Halparin L, of Two Commercial Fibrosis Marker Panels Ramji A, Telford J, Whittaker S, Enns R. Add-on (FibroSURE and FIBROSpect II) During Baillie H. Eponyms in medicine. Can J Gen Intern cases in the endoscopy unit: factors that affect Albinterferon alfa-2b Combination Therapy for Med 2009;4(2):77-78. volume. Canadian Journal of Gastroenterology Chronic Hepatitis C. Journal of Viral Hepatitis. 2009;23:485-8. 2009; 16: 178-86. Hatala, Dr. Rose Yoshida, Dr. Eric M. Eric M. Yoshida, Morris Sherman, Vincent G. Hatala R, Scalese RJ, Cole G, Bacchus M, Kassen Bain, Curtis L. Cooper, Marc Deschenes, Paul J. B, Issenberg SB. Development and validation Michelle Buresi, Iman Zandiah, Alexander Nagy, Marotta, Samuel S. Lee, Mel Krajden, Helga of a cardiac findings checklist for use with Alan A. Weiss, William C. Yee, Audrey Spielman, Witt-Sullivan, Robert J. Bailey, Christopher Usaty, simulator-based assessments of cardiac physical Eric M, Yoshida. The Use of Endoscopic Kevork Peltekian. Re-Treatment with examination competence. Simulation in Ultrasonography (EUS) and Magnetic Resonance Peginterferon alfa-2a and Ribavirin in Patients Healthcare. 2009; 4(1):17-21. Imaging (MRI) in the Preoperative Staging of with Chronic Hepatitis C who have Relapsed or Rectal Villous Tumors: a Case of Overstaging by not Responded to a First Course of Pegylated Sidhu RS, Hatala R, Barron S, Broudo M, Pachev Magnetic Resonance Imaging (MRI). Canadian Interferon-Based Therapy. Canadian Journal of G, Page G. Reliability and acceptance of the Journal of Gastroenterology 2009; 9: 639-41. Gastroenterology 2009; 23: 180-84. mini-CEX as a performance assessment of practicing physicians. Acad Med. 2009; Janakie Singham, Eric M. Yoshida, Charles Avidan U. Neumann, Keyur Patel, Vincent G. 84(10):S113-115. H. Scudamore. Choledochal Cysts: A Bain, Eric M. Yoshida, G. Mani Subramanian. Comprehensive Review: A Three Part Early Prediction of SVR at Day 3 of Treatment Comprehensive Review: Part I – A Review of with Albinterferon alfa-2b in Patients with Hawley, Dr. Philippa H. Classification and Pathogenesis. Canadian Hepatitis C Genotype 2,3 Infection. Liver Journal of Surgery 2009; 52: 434-40. International 2009; 29: 1350-55. Hawley P, Beddard-Huber E, Grose C, McDonald W, Lobb D and Malysh L. Intrathecal infusions Janakie Singham, Eric M. Yoshida, Charles Avidan.U Neumann, Stephen Pianko, Stefan for intractable cancer pain: a qualitative study H. Scudamore. Choledochal Cysts: A Zeuzem, Eric M. Yoshida, Yves Benhamou, of the impact on a case series of patients and Comprehensive Review: A Three Part Moshe Mishan, John G. McHutchinson, Erik caregivers. Pain Res Manage 2009; 14(5):371- Comprehensive Review: Part II – Diagnosis of Pulkstenis G. Mani Subramanian. Positive and 379. Choledochal Cysts. Canadian Journal of Surgery Negative Prediction of Sustained Virologic 2009; 52: 506-11. Response at Week 2 and 4of treatment with Hui D, Con A, Christie G, Hawley P. Goals of Care Albinterferon alfa-2b or Peginterferon alfa 2-a and End-of-Life Decision Making for Hospitalized Peter Phillips, Jason K. Lee, Charlie Wang, Eric in Treatmen-Naïve Patients with Genotype Patients at a Canadian Tertiary Care cancer Yoshida, Julio Montaner. Chylous Ascites: A Late 1, Chronic Hepatitis C. Journal of Hepatology Center. J Pain Symptom Manage 2009;38:871- Complication of Intraabdominal Mycobacterium 2009; 51: 21-28. 881. Avium Complex Immune Reconstitution Syndrome in HIV-Infected Patients. International John-Baptiste, AA., Tomlinson, G., Hsu, PC., Holmes, Dr. Cheryl L. Journal of STD and AIDS 2009; 20: 285-87. (MS Krajden, M., Heathcote, EJ., Laporte, A., Yoshida, IJSA-08-275). EM., Anderson, FH., Krahn, MD. Sustained Russell JA, Walley KR, Gordon AC, Cooper Responders Have Better Quality of Life and DJ, Hébert PC, Singer J, Holmes CL, Mehta S, Priscilla C. Hsu, Mel Krajden, Eric M. Yoshida, Productivity Compared With Treatment Failures Granton JT, Storms MM, Cook DJ, Presneill Frank H. Anderson, George Tomlinson, Murray Long After Antiviral Therapy for Hepatitis C. The JJ; Dieter Ayers for the Vasopressin and D. Krahn. Does Cirrhosis Affect Quality of Life American Journal of Gastroenterology, 2009, Septic Shock Trial Investigators. Interaction of in Hepatitis C-Virus Infected Patients? Liver 104: 2439-2448. vasopressin infusion, corticosteroid treatment, International 2009; 29: 449-58.(MS# 08- LIV int and mortality of septic shock. Crit Care Med. 00151.R1). 2009 Mar;37(3):811-8. 13 | Annual Report 2009 Publication List

Holmes CL, Walley K. Vasoactive Drugs for King KM, Khan NA, Quan H. Ethnic variation in Côté AM, Lam EM, von Dadelszen P, Mattman A, Vasodilatory Shock in ICU. Current Opinion in acute myocardial infarction presentation and Magee LA. Monitoring renal function in Critical Care. 2009 Oct; 15 (5): 398-402. access to care. Am J Cardiol. 2009;103(10):1368- hypertensive pregnancy. Hypertens Pregn 2009 73. (also featured on OMNI television, CTV news Nov27 [Epub ahead of print] (MS# LHIP-2008- Kassen, Dr. Barry O. Calgary). 0088).

Millington SJ, Wong RY, Kassen B, Roberts JM, Kelli Kalb, Stephen Shalansky, Michael Legal, Magee LA for the CHIPS Study Group. The CHIPS Ma, IW. Improving internal medicine residents’ Nadia Khan, Irene Ma, Garth Hunte. Unintended Trial (Control of Hypertension In Pregnancy performance, knowledge and confidence in Medication Discrepancies Associated with Study) – Protocol (17Mar2009). Lancet 2009 central venous catheterization using simulators. Reliance on Prescription Databases for (http://www.thelancet.com/protocol- J Hosp Med. 2009 Sept;4(7):410-6. Medication Reconciliation on Admission to a reviews/09PRT-3980). General Medical Ward. Canadian Journal of Hatala R, Scalese RJ, Cole G, Bacchus CM, Kassen Hospital Pharmacy. 2009 62(4). Magee LA, Sibai BM, Walkinshaw S, Abalos E, B, Issenberg SB. Development and validation of von Dadelszen P for the CHIPS Study Group. a cardiac findings checklist for use with Wenner JB, Norena M, Khan N, Palepu A, Ayas Special situations in the management of simulator-based assessments of cardiac physical NT, Wong H, Dodek PM. Reliability of intensive hypertension - Control of hypertension in examination competence. Simulation in care unit admitting and comorbid diagnoses, pregnancy. Current Hypertension Reports Healthcare. 2009; 4(1): 17-21. race, elements of Acute Physiology and Chronic 2009;11:429-36. Health Evaluation II score, and predicted Kennedy, Dr. James R. probability of mortality in an electronic Ma, Dr. Irene W. intensive care unit database. J Crit Care. 2009 Lepik KJ, Levy AR, Sobolev BG, Purssell RA, De Jul 2. [epub ahead of print]. Wong RY, Saber SS, Ma I, Roberts JM. Using Witt CR, Erhardt GD, Kennedy JR, Daws DE, television shows to teach communication skills Brignall JL. Adverse Drug Events Associated with Hude Quan, Nadia Khan, Brenda Hemmelgarn, in internal medicine residency. BMC Med Educ. the Antidotes for Methanol and Ethylene Glycol Karen Tu, Guanmin Chen, Norm Campbell, 2009 Feb 3;9(1):9. [Epub ahead of print]. Poisoning: A Comparison of Ethanol and Michael D Hill, William Ghali, Finlay McAlister Fomepizole. Ann Emerg Med 2009, 53:439-450. for the Canadian Hypertension Education Kelli Kalb, Stephen Shalansky, Michael Legal, Program Outcomes Research Task Force. Nadia Khan, Irene Ma, Garth Hunte. Unintended Khan, Dr. Nadia A. Validation of a Case definition to Define medication discrepancies associated with Hypertension Using Administrative Data. reliance on prescription databases for Hypertension 2009; 54;1423-1428. Campbell NR, Khan NA, Hill MD, Tremblay G, medication reconciliation on admission to Lebel M, Kaczorowski J, McAlister FA, Lewanczuk a general medical ward. Can J Hosp Pharm RZ, Tobe S; Canadian Hypertension Education Magee, Dr. Laura A. 62(6):284-289, 2009. Program. 2009 Canadian Hypertension Education Program recommendations: the Rey E, Garneau P, David M, Gauthier R, Leduc L, Millington SJ, Wong RY, Kassen BO, Roberts JM, scientific summary--an annual update. Can J Michon N, Morin F, Khan SR, Magee LA, Ma IW. Improving internal medicine residents’ Cardiol. 2009;25(5):271-7. Rodgers M . Dalteparin for the prevention performance, knowledge, and confidence in of recurrence of severe placental-mediated central venous catheterization using simulators. Padwal RS, Hemmelgarn BR, Khan NA, Grover S, complications of pregnancy in women without J Hosp Med. 2009 Sep 14;4(7):410-416. McKay DW, Wilson T, Penner B, Burgess E, thrombophilia: a pilot a randomized controlled McAlister FA, Bolli P, Hill MD, Mahon J, Myers trial. J Thromb Haemost 2009;7(1):58-64 Palepu, Dr. Anita MG, Abbott C, Schiffrin EL, Honos G, Mann K, (MSFHR). Tremblay G, Milot A, Cloutier L, Chockalingam A, Martin I, Palepu A, Wood E, Li K, Montaner J, Rabkin SW, Dawes M, Touyz RM, Bell C, Burns Massey KA, Ansermino M, von Dadelszen P, Kerr T. Violence among street-involved youth: KD, Ruzicka M, Campbell NR, Vallée M, Prasad R, Morris TJ, Liston RM, Magee LA. What is the role of methamphetamine. European Lebel M, Tobe SW; Canadian Hypertension SNOMED-CT® and why should the ISSHP care? Addiction Research. 2009; 15: 32-8. Education Program. The 2009 Canadian Hypertens Pregn 2009;28(1):119-21 (IWRH, Hypertension Education Program MSFHR). Roberts, Dr. James M. recommendations for the management of hypertension: Part 1--blood pressure Magee LA; Yong PJ; Espinosa V Côté AM; Chen I, Wong RY, Saber SS, Ma I, Roberts JM. Using measurement, diagnosis and assessment of risk. von Dadelszen P. Expectant management of television shows to teach communication skills Can J Cardiol. 2009;25(5):279-86. pre-eclampsia remote from term: A structured in internal medicine residency. BMC Med Educ. systematic review. Hypertens Pregn 2009;25:1- 2009 Feb 3; 9(1):9. Khan NA, Hemmelgarn B, Herman RJ, Bell CM, 36 (MSFHR). Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin Magee LA, von Dadelszen P. The management of GERIATRIC MEDICINE EL, Campbell NR, Moe G, Prasad R, Arnold MO, severe hypertension. In: Severe pre-eclampsia. Campbell TS, Milot A, Stone JA, Jones C, Ogilvie Eds: Cleary KL and Sibai BM. Semin Perinatol RI, Hamet P, Fodor G, Carruthers G, Burns KD, 2009;33(3):138-42 (MSFHR). Cook, Dr. Wendy L. Ruzicka M, DeChamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, von Dadelszen P, Menzies JM, Payne B, Magee Cook WL. The intersection of geriatrics and McFarlane P, Vallée M, Howlett J, Bacon SL, LA, Predicting adverse outcomes in women with chronic kidney disease: Frailty and disability Lindsay P, Gilbert RE, Lewanczuk RZ, Tobe S; severe preeclampsia. In: Severe pre-eclampsia. among older adults with kidney disease. Canadian Hypertension Education Program. The Eds: Cleary KL and Sibai BM. Semin Perinatol Advances in Chronic Kidney Disease 2009 2009 Canadian Hypertension Education Program 2009;33(3):152-7 [CIHR, WHO, MSFHR]. Nov;16(6):420-9. recommendations for the management of hypertension: Part 2--therapy. Can J Cardiol. Castillo E, Magee LA, Bichet D, Halperin M. Lee, Dr. Philip E. 2009;25(5):287-98. Hereditory nephrogenic diabetes insipidus: A major conundrum during labour and delivery. Wong, CL, Bansback N, Lee PE & Anis AH. Cost- NDT 2009 04 August;doi: 10.1093/ndtplus/ Effectiveness: Cholinesterase Inhibitors and sfp098 [MSFHR]. Memantine in Vascular Dementia. Can J Neuro Sci 2009; 36: 735-739.

Publication List Annual Report 2009 | 14

Madden, Dr. Kenneth M. Mui TS, Man JM, McElhaney JE, Sandford AJ, HEMATOLOGY Coxson HO, Birmingham CL, Li Y, Man SF, Sin DD. Madden KM, Lockhart C. Arterial baroreflex Telomere length and chronic obstructive Abou-Mourad, Dr. Yasser R. function in older adults with neurocardiogenic pulmonary disease: evidence of accelerated aging. J Am Geriatr Soc. 57:2372-4, 2009. syncope, Clinical Investigative Medicine Abou-Mourad YR, Lau BC, Barnett MJ, Forrest 32(3):E191-E198, 2009. DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd Meneilly, Dr. Graydon S. JD, Smith CA, Song KW, Sutherland HJ, Toze Rhynold E, Lockhart C, Liu-Ambrose T, Madden CL, Lavoie JC. Long-term outcome after Allo- KM. Increasing Arterial Stiffness is Associated Guimaraes C, Marra CA, Gill S, Simpson S, SCT: close follow-up on a large cohort treated with Cognitive Dysfunction. Canadian Journal of Meneilly G, Queiroz RHC, Lynd LD. Socio- with myeloablative regimens. Bone Marrow Geriatrics, Volume 12(2):24-29, 2009. economic Differences in Preferences and Transplant. 2009 Jul 13. Willingness-To-Pay for Insulin Delivery Systems Madden KM, Lockhart C, Cuff D, Potter TF, in Type 1 and Type 2 Diabetes. Diabetes Matos-Fernandez NA, Abou Mourad YR, Meneilly GS. Short-term Aerobic Exercise Technology and Therapeutics, 11:567-73, 2009. Caceres W, Kharfan-Dabaja MA. Current Reduces Arterial Stiffness in Older Adults status of allogeneic hematopoietic stem cell with Type 2 Diabetes, Hypertension and Abu-Hamdah R, Rabiee A, Meneilly GS, Shannon transplantation for paroxysmal nocturnal Hypercholesterolemia. Diabetes Care, 2009 Jun RP, Andersen DK, Elahi D. The Extra-Pancreatic hemoglobinuria. Biol Blood Marrow Transplant 9. [Electronic publication ahead of print DOI: Effects of GLP-1 and Related Peptides. J Clin 15(6):656-61, 2009. 10.2337/dc09-0149]. This paper was featured Endocrinol Metab. 2009 94: 1843-1852. as the sixth most read Geriatric Medicine article Wright MP, Shepherd JD, Barnett MJ, Nantel in the ACP (American College of Physicians) Madden KM, Lockhart C, Cuff D, Potter TF, SH, Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Journal Club “Hit Parade” for August 2009. Meneilly, GS. Short-term Aerobic Exercise Song KW, Abou Mourad YR, Narayanan S, Power Reduces Arterial Stiffness in Older Adults MM, Smith CA, Forrest DL. Response to Tyrosine Halaschek-Wiener J, Amirabbasi-Beik M, with Type 2 Diabetes, Hypertension and Kinase Inhibitor Therapy in Patients with Monfared N, Pieczyk M, Sailer C, Kollar A, Hypercholesterolemia. Diabetes Care. 2009 Chronic Myeloid Leukemia Relapsing in Chronic Thomas R, Agalaridis G, Yamada S, Oliveira L, 32:1531-5. and Advanced Phase Following Allogeneic Collins JA, Meneilly G, Marra MA, Madden KM, Hematopoietic Stem Cell Transplantation. Biol Le ND, Connors JM, and Brooks-Wilson AR. Klimek AM, Soukhatcheva G, Thompson DM, Blood Marrow Transplant 2009 [Epub ahead of Genetic Variation in Healthy Oldest-Old. PLoS Warnock GL, Salehi M, Rilo H, D’Alessio D, print]. One 4(8): e6641, 2009. Meneilly GS, Panagiotopoulos C, Verchere CB. Impaired Proinsulin Processing is a Nevill TJ, Shepherd JD, Sutherland HJ, Abou Halaschek-Wiener J, Amirabbasi-Beik M, Characteristic of Transplanted Islets. Am J Mourad YR, Lavoie JC, Barnett MJ, Nantel SH, Monfared N, Pieczyk M, Sailer C, Kollar A, Transplant 2009 9: 2119-2125. Toze CL, Hogge DE, Forrest DL, Song KW, Power Thomas R, Agalaridis G, Yamada S, Oliveira L, MM, Nitta JY, Dai Y, Smith CA. IPSS poor-risk Collins JA, Meneilly G, Marra MA, Madden KM, Halaschek-Wiener J, Amirabbasi-Beik M, karyotype as a predictor of outcome for patients Le ND, Connors JM, Brooks-Wilson AR. Genetic Monfared N, Pieczyk M, Sailer C, Kollar A, with myelodysplastic syndrome following Variation in Healthy Oldest-Old. PLoS ONE 2009 Thomas R, Agalaridis G, Yamada S, Oliveira L, myeloablative stem cell transplantation. Biol 4(8): e6641. doi:10.1371/journal.pone.0006641. Collins JA, Meneilly G, Marra MA, Madden KM, Blood Marrow Transplant 15(2):205-13, 2009. Le ND, Connors JM, Brooks-Wilson AR. Genetic McElhaney, Dr. Janet E. Variation in Healthy Oldest-Old. PLoS ONE 2009 Abou Mourad YR, Kharfan-Dabaja MA, 4: e6641. Song KW & Nantel SH. Allogeneic stem cell McElhaney JE. Prevention of infectious diseases transplantation in adult acute lymphoblastic in older adults through immunization: The Guimarães C, Marra CA, Colley L, Gill S, Simpson leukemia: a comprehensive review. Leuk challenge of the senescent immune response. SH, Meneilly GS, Queiroz RH, Lynd LD. A Lymphoma 17: 1-11, 2009. Expert Rev Vaccines. 8:593-606, 2009. valuation of patients’ willingness-to-pay for insulin delivery in diabetes. Int J Assess Health Barnett, Dr. Michael J. McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, Care. 2009 Jul;25(3):359-66. Hager WD, Barry MB, Kleppinger A, Wang Y, Forrest DL, Trainor S, Brinkman RR, Barnett MJ, Bleackley RC. Granzyme B: Correlates with Wong, Dr. Roger Y. Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, protection and enhanced CTL response to Toze CL, Sutherland HJ, Song KW, Lavoie JC, influenza vaccination in older adults. Vaccine. Wong RY, Saber SS, Ma I, Roberts JM. Using Power MM, Abou-Mourad Y & Smith CA. 27:2418-2425, 2009. television shows to teach communication skills Cytogenetic and molecular responses to in internal medicine residency. BMC Medical standard-dose imatinib in chronic myeloid Monto AS, Ansaldi F, Aspinall R, McElhaney JE, Education 2009; revisions with editor. (Senior leukemia are correlated with Sokal risk scores Montaño LF, Nichol KL, Puig-Barberà J, Schmitt J, Author. Supervised Mr. Saber). and duration of therapy but not trough imatinib Stephenson I. Influenza control in the 21st plasma levels. Leuk Res 33: 271-275, 2009. century: Optimizing protection of older adults. Millington SJ, Wong R, Kassen BO, Roberts JM, Vaccine. 2009 Jun 23. Ma IWY. Improving internal medicine residents’ Wright MP, Shepherd JD, Barnett MJ, Nantel SH, performance, knowledge, and confidence in Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, McElhaney JE, Effros RB. Immunosenescence: central venous catheterization using simulators. Song KW, Abou Mourad YR, Narayanan S, Power what does it mean to health outcomes in older Journal of Hospital Medicine 2009; 4: 410–416 MM, Smith CA, Forrest DL. Response to adults? Curr Opin Immunol. 21:418-24, 2009. (Co-Senior Author with Dr. IWY Ma). Tyrosine Kinase Inhibitor Therapy in Patients with Chronic Myeloid Leukemia Relapsing Johnson RW, McElhaney J. Postherpetic Cuncic C, Miller WC, Weger L, Wong RYM. in Chronic and Advanced Phase Following neuralgia in the elderly. Int J Clin Pract. 2009 Community mobility of older patients following Allogeneic Hematopoietic Stem Cell Sep;63:1386-91, 2009. acute hospitalization. Can J Geriatr 2009; 12(2): Transplantation. Biol Blood Marrow 80-83 (Senior Author. Supervised Dr. Cuncic). Transplant 2009 Epub ahead of print]. Sambhara S, McElhaney JE. Immunosenescence and influenza vaccine efficacy. Curr Top Wong RY, Liao J, Li A, Parmar N. Perioperative Microbiol Immunol. 2009;333:413-29. considerations in frail older adults. Can J Gen Int Med 2009; 4 (2): 70-72 (Senior Author, Supervised Drs. Liao, Li, Parmar).

15 | Annual Report 2009 Publication List

Maurer-Spurej E, Labrie A, Pittendreigh C, myeloablative stem cell transplantation. Biol Fisher CL, Pineault N, Brookes C, Helgason CD, Chipperfield K, Smith C, Heddle N, Liu Y, Yi Blood Marrow Transplant 15(2):205-13, 2009. Ohta H, Bodner C, Hess JL, Humphries RK & Q-L & Barnett M. Platelet quality measured Brock HW. Loss-of-function additional sex with dynamic light scattering correlates Forrest DL, Trainor S, Brinkman RR, Barnett MJ, combs-like1 mutations disrupt hematopoiesis with transfusion outcome in hematologic Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, but do not cause severe myelodysplasia or malignancies. Transfusion 49:2276-2284, 2009. Toze CL, Sutherland HJ, Song KW, Lavoie leukemia. Blood 115: 38-46, 2009. JC, Power MM, Abou-Mourad Y, Smith CA. Broady, Dr. Raewyn Cytogenetic and molecular responses to Heuser M, Kuchenbauer F, Argiropoulos B, standard-dose imatinib in chronic myeloid Sekulovic S, Leung M, Stasiak M, Ganser A & Broady R, Yu J, Levings MK. ATG-induced leukemia are correlated with Sokal risk scores Humphries RK. Priming reloaded? Blood 114: expression of FOXP3 in human CD4(+) T cells and duration of therapy but not trough imatinib 925-926, 2009. in vitro is associated with T-cell activation and plasma levels. Leuk Res 33(2):271-5, not the induction of FOXP3+ T regulatory cells. 2009. Heuser M, Sly L, Argiropoulos B, Kuchenbauer F, Blood 114: 5003-5006, 2009. Lai C, Weng A, Leung M, Lin G, Brookes C, Fung Forrest D, Trainor S, Brinkman R, Barnett M, S, Valk PJ, Delwel R, Lowenberg B, Krystal G & Conway, Dr. Edward M. Hogge D, Nevill T, Shepherd J, Nantel S, Toze C, Humphries RK. Modelling the functional Sutherland H, Song K, Lavoie J, Power M, Abou- heterogeneity of leukemia stem cells: Role of Delvaeye M, De Vriese A, , Zwerts F, Betz I, Mourad Y, Smith C. Correlation between trough STAT5 in leukemia stem cell self-renewal. Blood Moons M, Autiero M, Conway EM. Role of the 2 plasma concentration and clinical response in 114: 3983-3993, 2009. zebrafish survivin genes in vasculo-angiogenesis, chronic myeloid leukemia. Leukemia Research neurogenesis, cardiogenesis and hematopoiesis. 33: 1149-1150, 2009. Reindl C, Quentmeier H, Petropoulos K, Greif PA, BMC Developmental Biology 2009 Mar 26;9:2. Benthaus T, Argiropoulos B, Mellert G, Vempati Hogge, Dr. Donna S, Duyster J, Buske C, Bohlander SK, Humphries Delvaeye M, De Vriese A, Esmon CT, Esmon KR, Hiddemann W & Spiekermann K. CBL exon N, Ferrell G, Claes B, Lambrechts D, Remuzzi Wright MP, Shepherd JD, Barnett MJ, Nantel SH, 8/9 mutants activate the FLT3 pathway and G, Noris M, Conway EM. Mutations in Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, cluster in core binding factor/11q deletion acute thrombomodulin in hemolytic-uremic Song KW, Abou Mourad YR, Narayanan S, Power myeloid leukemia/myelodysplastic syndrome syndrome. New England Journal of MM, Smith CA, Forrest DL. Response to subtypes. Clin Cancer Res 15: 2238-2247, 2009. Medicine (IF 51) 361:345-357, 2009. Tyrosine Kinase Inhibitor Therapy in Patients with Chronic Myeloid Leukemia Relapsing Jackson, Dr. Shannon C. Fukuda S, Singh P, Abe M, Conway EM, Moh in Chronic and Advanced Phase Following A, Yamaguchi S, Pelus L. Survivin mediates Allogeneic Hematopoietic Stem Cell Fieldwalker M, Jackson S.C., Seal D. High aberrant hematopoietic progenitor cell Transplantation. Biol Blood Marrow Transoxygenator Pressure Gradient in a proliferation and acute leukemia in mice Transplant 2009 [Epub ahead of print]. Patient With Polycythemia Vera. Journal of induced by internal tandem duplication of Flt3. Cardiothoracic and Vascular Anesthesia. April Blood Jul 9;114(2):394-403, 2009. Forrest DL, Trainor S, Brinkman RR, Barnett 2009. DOI: 10.1053/j.jvca.2009.01.031. MJ, Hogge DE, Nevill TJ, Shepherd JD, Nantel Delvaeye M, Conway EM. Coagulation and SH, Toze CL, Sutherland HJ, Song KW, Lavoie Jackson SC, Sinclair GD, Cloutier S, Duan Z, Innate Immune responses: Can they be viewed JC, Power MM, Abou-Mourad Y & Smith CA. Rand ML & Poon M-C. The Montreal platelet separately? Blood 2009. 114(2):2367-74. Cytogenetic and molecular responses to syndrome kindred has type 2B von Willebrand standard-dose imatinib in chronic myeloid disease with the VWF V1316M mutation. Blood Conway EM. Super factor B”- gets atypical HUS. leukemia are correlated with Sokal risk scores 113:3348-3351, 2009. Blood 2009. 114(13):2572-4. and duration of therapy but not trough imatinib plasma levels. Leuk Res 33:271-275, 2009. Lansdorp, Dr. Peter M. Forrest, Dr. Donna L. Muranyi AL, Dedhar S & Hogge DE. Combined Banath JP, Banuelos CA, Klokov D, MacPhail SM, Abou-Mourad YR, Lau BC, Barnett MJ, Forrest inhibition of integrin linked kinase and FMS-like Lansdorp PM & Olive PL. Explanation for DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, tyrosine kinase 3 is cytotoxic to acute myeloid excessive DNA single-strand breaks and Smith CA, Song KW, Sutherland HJ, Toze CL, leukemia progenitor cells. Exp Hematol 37: endogenous repair foci in pluripotent mouse Lavoie JC. Long-term outcome after Allo-SCT: 450-460, 2009. embryonic stem cells. Exp Cell Res 315: 1505- close follow-up on a large cohort treated 1520, 2009. with myeloablative regimens. Bone Marrow Calado RT, Regal JA, Hills M, Yewdell WT, Transplant. 2009 Jul 13 [Epub ahead of print]. Dalmazzo LF, Zago MA, Lansdorp PM, Hogge Breakey VR, Meyn S, Ng V, Allen C, Dokal I, D, Chanock SJ, Estey EH, Falcao RP & Young Lansdorp PM, Abla O & Dror Y. Hepatitis- Wright MP, Shepherd JD, Barnett MJ, Nantel SH, NS. Constitutional hypomorphic telomerase associated aplastic anemia presenting as a Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, mutations in patients with acute myeloid familial bone marrow failure syndrome. J Song KW, Abou Mourad YR, Narayanan S, Power leukemia. Proc Natl Acad Sci USA 106: 1187- Pediatr Hematol Oncol 31: 884-887, 2009. MM, Smith CA, Forrest DL. Response to 1192, 2009. Tyrosine Kinase Inhibitor Therapy in Patients Calado RT, Regal JA, Hills M, Yewdell WT, with Chronic Myeloid Leukemia Relapsing Humphries, Dr. Richard Keith Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, in Chronic and Advanced Phase Following Chanock SJ, Estey EH, Falcao RP & Young Allogeneic Hematopoietic Stem Cell Heuser M*, Yap D*, Leung M, de Algara TR, NS. Constitutional hypomorphic telomerase Transplantation. Biol Blood Marrow Tafech A, McKinney S, Dixon J, Thresher R, mutations in patients with acute myeloid Transplant 2009 Epub ahead of print]. Colledge B, Carlton M, Humphries RK** & leukemia. Proc Natl Acad Sci USA 106: 1187- Aparicio S**. Loss of MLL5 results in pleiotropic 1192, 2009. Nevill TJ, Shepherd JD, Sutherland HJ, Abou hematopoietic defects, reduced neutrophil Mourad YR, Lavoie JC, Barnett MJ, Nantel SH, immune function and extreme sensitivity to Calado RT, Regal JA, Kleiner DE, Schrump DS, Toze CL, Hogge DE, Forrest DL, Song KW, Power DNA demethylation. Blood 113:1432-1443, Peterson NR, Pons V, Chanock SJ, Lansdorp MM, Nitta JY, Dai Y, Smith CA. IPSS poor-risk 2009. (*authors contributed equally to this PM & Young NS. A spectrum of severe liver karyotype as a predictor of outcome for patients study; **co-senior authors). and blood disorders associate with telomerase with myelodysplastic syndrome following mutations. PLoS One 4: e7926 2009.

Publication List Annual Report 2009 | 16

Decker ML, Chavez E, Vulto I & Lansdorp PM. Leger, Dr. Chantal S. Nevill TJ, Shepherd JD, Sutherland HJ, Abou Telomere length in Hutchinson-Gilford progeria Mourad YR, Lavoie JC, Barnett MJ, Nantel SH, syndrome. Mech Ageing Dev 130: 377-383, Leger CS, Leitch HA, Galbraith PF, Li CH & Vickars Toze CL, Hogge DE, Forrest DL, Song KW, Power 2009. LM. Acute leukemia in patients sixty years of MM, Nitta JY, Dai Y, Smith CA. IPSS poor-risk age and older – a twenty year single institution karyotype as a predictor of outcome for patients Falconer E, Chavez EA, Henderson A, Poon SSS, review. Am J Clin Oncol 32: 137-141, 2009. with myelodysplastic syndrome following McKinney S, Brown L, Huntsman DG & Lansdorp myeloablative stem cell transplantation. Biol PM. Identification of sister chromatids by DNA Leitch, Dr. Heather A. Blood Marrow Transplant 15(2):205-13, 2009. template strand sequences. Nature 463: 93-7, 2009. Leger CS, Leitch HA, Galbraith PF, Li CH, Vickars Forrest DL, Trainor S, Brinkman RR, Barnett MJ, LM. “Acute Leukemia in Patients Sixty Years of Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, Hills M & Lansdorp PM. Short telomeres Age and Older; A Twenty Year Single Institution Toze CL, Sutherland HJ, Song KW, Lavoie resulting from heritable mutations in the Review”. Am J Clin Oncol. 2009 Apr;32(2):137- JC, Power MM, Abou-Mourad Y, Smith CA. telomerase reverse transcriptase gene 41. Cytogenetic and molecular responses to predispose for a variety of malignancies. Ann N standard-dose imatinib in chronic myeloid Y Acad Sci 1176: 179-190, 2009. Leitch HA and Vickars LM. “Supportive Care and leukemia are correlated with Sokal risk scores Chelation Therapy in MDS; Are We Saving Lives and duration of therapy but not trough imatinib Hills M, Lucke K, Chavez EA, Eaves CJ & or Just Lowering Iron?” Hematology 2009, plasma levels. Leuk Res 33(2):271-5, 2009. Lansdorp PM. Probing the mitotic history and American Society of Hematology Education developmental stage of hematopoietic cells Program Book: 664-72. Ramadan, Dr. Khaled M. using single telomere length analysis (STELA). Blood 113: 5765-5775, 2009. Leitch HA, Chase JM, Goodman TA, Ezzat H, Leitch HA, Chase JM, Goodman TA, Ezzat H, Rollins MD, Wong DH, Badawi M, Leger CS, Rollins MD, Wong DH, Badawi M, Leger CS, Lansdorp PM. Telomeres and disease. EMBO J Ramadan KM, Barnett MJ, Foltz LM, Vickars LM. Ramadan KM, Barnett MJ, Foltz LM, Vickars LM. 28: 2532-2540, 2009. “Improved survival in red blood cell transfusion Improved survival in red blood cell transfusion dependent patients with primary myelofibrosis dependent patients with primary myelofibrosis Lee, Dr. Agnes (PMF) receiving iron chelation therapy”. (PMF) receiving iron chelation therapy. Hematol Hematol Oncol. 2009 Jun 25. [Epub ahead of Oncol 2009 Jun 25. [Epub ahead of print]. Fitchett D, Eikelboom J, Fremes S, Mazer D, print]. Singh S, Bittira B, Brister s, Graham J, Gupta Schrader, Dr. John W. M, Karkouti K, Lee AY, Love M, McArthur R, Li, Dr. Charles H. Peterson M Verma S & Yau T. Dual Antiplatelet Kolobova E, Efimov A, Kaerina I, Rishi AK, therapy in patients requiring urgent coronary Leger C, Leitch H, Galbraith P, Li CH, Vickars L. Schrader JW, Ham A, Larocca MC & Goldenring artery bypass grafting surgery: A position Acute leukemia in patients sixty years of age and JR. Microtubule-dependent association of statement of the Canadian Cardiovascular older – a twenty year single institution review. AKAP350A and CCAR1 with RNA stress granules. Society. Can J Cardiol 25: 683-689, 2009. AJCO 32(2): 137-141, 2009. Exp Cell Res 315:542-555, 2009.

Cook D, Sinuff T, Zytaruk N, Rabbat C, Nantel, Dr. Stephen H. Lorén CE, Schrader JW, Ahlgren U & Gunhaga Lee A, O’Donnell M, Thabane L, Linkins L, L. FGF signals induce Caprin2 expression in the Treleaven D, Patel R, Meade M, Crowther M, Wright MP, Shepherd JD, Barnett MJ, Nantel SH, vertebrate lens. Differentiation 77:386-394, Marshall J & Douketis J. Event adjudication 2009. and data monitoring in an intensive care unit Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, observational study of thromboprophylasis. J Song KW, Abou Mourad YR, Narayanan S, Power Crit Care 24:168-175, 2009. MM, Smith CA, Forrest DL. Response to Shepherd, Dr. John D. Tyrosine Kinase Inhibitor Therapy in Patients Lee AY. Anticoagulation in the treatment of with Chronic Myeloid Leukemia Relapsing Abou-Mourad YR, Lau BC, Barnett MJ, Forrest established venous thromboembolism in in Chronic and Advanced Phase Following DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, patients with cancer. J Clin Oncol 27:4895-4901, Allogeneic Hematopoietic Stem Cell Smith CA, Song KW, Sutherland HJ, Toze CL, 2009. Transplantation. Biol Blood Marrow Transplant Lavoie JC. Long-term outcome after Allo-SCT: 2009 [Epub ahead of print]. close follow-up on a large cohort treated Carrier M, Le Gal G, Cho R, Tierney A, Rodger with myeloablative regimens. Bone Marrow M, Lee AY. Dose escalation of low molecular Nevill, Dr. Thomas J. Transplant 2009 Jul 13 [Epub ahead of print]. weight heparin to manage recurrent venous thromboembolic events despite systemic Wright MP, Shepherd JD, Barnett MJ, Nantel SH, Wright MP, Shepherd JD, Barnett MJ, Nantel SH, anticoagulation in cancer patients. J Thromb Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Haemost 7:760-765, 2009. Song KW, Abou Mourad YR, Narayanan S, Power Song KW, Abou Mourad YR, Narayanan S, Power MM, Smith CA, Forrest DL. Response to MM, Smith CA, Forrest DL. Response to Lyman GH, Khorana AA, Kuderer NM & Lee Tyrosine Kinase Inhibitor Therapy in Patients Tyrosine Kinase Inhibitor Therapy in Patients AY. Cancer and Thrombosis: back to the future with Chronic Myeloid Leukemia Relapsing with Chronic Myeloid Leukemia Relapsing renewed interest in an old problem. Cancer in Chronic and Advanced Phase Following in Chronic and Advanced Phase Following Invest 27:472-473, 2009. Allogeneic Hematopoietic Stem Cell Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant Transplantation. Biol Blood Marrow Transplant Scully M & Lee AY. The challenge of cancer and [Epub ahead of print]. 2009 [Epub ahead of print]. thromboembolic disease: current trends and recommendations. Oncology Exchange 8: 6-10, Abou-Mourad YR, Lau BC, Barnett MJ, Forrest Nevill TJ, Shepherd JD, Sutherland HJ, Abou 2009. DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Mourad YR, Lavoie JC, Barnett MJ, Nantel SH, Smith CA, Song KW, Sutherland HJ, Toze CL, Toze CL, Hogge DE, Forrest DL, Song KW, Power Lee AY. Treatment of venous thromboembolism Lavoie JC. Long-term outcome after Allo-SCT: MM, Nitta JY, Dai Y, Smith CA. IPSS poor-risk in cancer patients. Best Pract Res Clin Haematol close follow-up on a large cohort treated karyotype as a predictor of outcome for patients 22:93-101, 2009. with myeloablative regimens. Bone Marrow with myelodysplastic syndrome following Transplant 2009 Jul 13 [Epub ahead of print]. myeloablative stem cell transplantation. Biol Blood Marrow Transplant 15(2):205-13, 2009.

17 | Annual Report 2009 Publication List

Forrest DL, Trainor S, Brinkman RR, Barnett MJ, Nevill TJ, Shepherd JD, Sutherland HJ, Abou Attarian, R., Bach, H., Bennie, C., and Av-Gay, Y. Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, Mourad YR, Lavoie JC, Barnett MJ, Nantel SH, (2009). Glutathione Disulfide and Toze CL, Sutherland HJ, Song KW, Lavoie Toze CL, Hogge DE, Forrest DL, Song KW, Power S-Nitrosoglutathione Detoxification by JC, Power MM, Abou-Mourad Y, Smith CA. MM, Nitta JY, Dai Y, Smith CA. IPSS poor-risk Mycobacterium tuberculosis Thioredoxin Cytogenetic and molecular responses to karyotype as a predictor of outcome for patients System. FEBS Letters. 583: 3215-3220. standard-dose imatinib in chronic myeloid with myelodysplastic syndrome following leukemia are correlated with Sokal risk scores myeloablative stem cell transplantation. Biol Gopalasawamy, R., Narayanan, S., Chen, B., and duration of therapy but not trough imatinib Blood Marrow Transplant 15(2):205-13, 2009. Jacobs, W. R., and Av-Gay, Y. (2009). The plasma levels. Leuk Res 33(2):271-5, 2009. serine/threonine kinase PknI controls the Forrest DL, Trainor S, Brinkman RR, Barnett MJ, growth of Mycobacterium tuberculosis upon Irvine DA, Shepherd JD. Recurrence of lymphoid Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, infection. FEMS microbiology Letters. 295:23-29. blast crisis over 20 years after successful sibling Toze CL, Sutherland HJ, Song KW, Lavoie allo-SCT for CML: short lived complete JC, Power MM, Abou-Mourad Y, Smith CA. Bowie, Dr. William R. cytogenetic response to imatinib. Bone Marrow Cytogenetic and molecular responses to Transplant 44(4):267-8, 2009. standard-dose imatinib in chronic myeloid Marra F, Marra CA, Richardson K, Lynd LD, leukemia are correlated with Sokal risk scores Kozyrskyj A, Patrick DM, Bowie WR, FitzGerald Smith, Dr. Clayton A. and duration of therapy but not trough imatinib JM. Antibiotic Use in children is associated with plasma levels. Leuk Res 33(2):271-5, 2009. increased risk of asthma. Pediatrics 2009; 123: Wright MP, Shepherd JD, Barnett MJ, Nantel SH, 1003-1010. Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Reece D, Song KW, Fu T, Roland B, Chang H, Song KW, Abou Mourad YR, Narayanan S, Power Horsman DE, Mansoor A, Chen C, Masih-Khan E, Phillips P, Chapman K, Sharp M, Harrison P, MM, Smith CA, Forrest DL. Response to Trieu Y, Bruyere H, Stewart DA, Bahlis NJ. Vortel J, Steiner T, Bowie W. Dexamethasone in Tyrosine Kinase Inhibitor Therapy in Patients Influence of cytogenetics in patients with Cryptococcus gattii Central Nervous System with Chronic Myeloid Leukemia Relapsing relapsed or refractory multiple myeloma treated Infection. Clinical Infectious Diseases 2009; 49: in Chronic and Advanced Phase Following with lenalidomide plus dexamethasone: adverse 591-595. Allogeneic Hematopoietic Stem Cell effect of deletion 17p13. Blood 114(3):522-5, Transplantation. Biol Blood Marrow Transplant 2009. Brunham, Dr. Robert C. 2009 [Epub ahead of print]. Sutherland, Dr. Heather J. Noël PA, Davoudi B, Brunham RC, Dubé LJ, Stewart DA, Smith C, McFarland R & Calandra Pourbohloul B. Time evolution of epidemic G. Pharmacokinetics and pharmacodynamics Wright MP, Shepherd JD, Barnett MJ, Nantel SH, disease on finite and infinite networks. Phys Rev of plerixafor in patients with non-Hodgkin’s Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt lymphoma and multiple myeloma. Biol Blood Song KW, Abou Mourad YR, Narayanan S, Power 2):026101. Marrow Transplant 15:39-46, 2009. MM, Smith CA, Forrest DL. Response to Tyrosine Kinase Inhibitor Therapy in Patients Ondondo BO, Brunham RC, Harrison WG, Kinyari Kent DG, Copley MR, Benz C, Dykstra BJ, with Chronic Myeloid Leukemia Relapsing T, Sheth PM, Mugo NR, Cohen CR. Frequency Ma E, Cheyna J, Zhao Y, Bowie M, Zhao M, in Chronic and Advanced Phase Following and magnitude of Chlamydia trachomatis Gasparetto M, Delaney A, Smith C, Marra M & Allogeneic Hematopoietic Stem Cell elementary body- and heat shock protein Eaves CJ. Prospective isolation and molecular Transplantation. Biol Blood Marrow Transplant 60-stimulated interferon gamma responses characterization of hematopoietic stem cells 2009 [Epub ahead of print]. in peripheral blood mononuclear cells and with durable self renewal potential. Blood endometrial biopsy samples from women with 113:6342-6350, 2009. Toze, Dr. Cynthia L high exposure to infection. J Infect Dis. 2009 Jun 15;199(12):1771-9. Rempel R, Gasparetto M, Glozak M, Smith Wright MP, Shepherd JD, Barnett MJ, Nantel SH, C & Nevins J. Loss of E2F2 accelerates Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Pourbohloul B, Ahued A, Davoudi B, Meza R, lymphomagenesis in myc overexpressing murine Song KW, Abou Mourad YR, Narayanan S, Power Meyers LA, Skowronski DM, Villaseñor I, Galván B-cells. PLoS Genet 5:e1000640, 2009. MM, Smith CA, Forrest DL. Response to F, Cravioto P, Earn DJ, Dushoff J, Fisman D, Tyrosine Kinase Inhibitor Therapy in Patients Edmunds WJ, Hupert N, Scarpino SV, Trujillo Song, Dr. Kevin W. with Chronic Myeloid Leukemia Relapsing J, Lutzow M, Morales J, Contreras A, Chávez in Chronic and Advanced Phase Following C, Patrick DM, Brunham RC. Initial human Abou-Mourad YR, Lau BC, Barnett MJ, Forrest Allogeneic Hematopoietic Stem Cell transmission dynamics of the pandemic (H1N1) DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Transplantation. Biol Blood Marrow Transplant 2009 virus in North America. Influenza Other Smith CA, Song KW, Sutherland HJ, Toze CL, 2009 [Epub ahead of print]. Respi Viruses. 2009 Sep;3(5):215-22. Lavoie JC. Long-term outcome after Allo-SCT: close follow-up on a large cohort treated Jiang X, Shen C, Yu H, Karunakaran P, Brunham with myeloablative regimens. Bone Marrow INFECTIOUS DISEASES RC. Differences in innate immune responses Transplant 2009 Jul 13 [Epub ahead of print]. correlate with differences in murine Av-Gay, Dr. Yossef Y. susceptibility to Chlamydia muridarum Wright MP, Shepherd JD, Barnett MJ, Nantel SH, pulmonary infection. Immunology. Sept 11 Sutherland HJ, Toze CL, Hogge DE, Nevill TJ, Miller CC, McMullin B, Ghaffari A, Pick N, Roscoe 2009; (published online ahead of print). Song KW, Abou Mourad YR, Narayanan S, Power D, Road J, Ghahary A, and Av-Gay Y. (2009). MM, Smith CA, Forrest DL. Response to Gaseous nitric oxide bactericidal activity Myers GS, Mathews SA, Eppinger M, Mitchell C, Tyrosine Kinase Inhibitor Therapy in Patients retained during intermittent high-dose short O’Brien KK, White OR, Benahmed F, Brunham with Chronic Myeloid Leukemia Relapsing duration exposure. Nitric Oxide 20(1):16-23. RC, Read TD, Ravel J, Bavoil PM, Timms P. in Chronic and Advanced Phase Following Evidence that human Chlamydia pneumoniae Allogeneic Hematopoietic Stem Cell Bach, H. Wong, D. and Av-Gay, Y. (2009). was zoonotically acquired. Journal of Transplantation. Biol Blood Marrow Transplant Mycobacterium tuberculosis PtkA is a novel Bacteriology. 2009 Dec;191(23):7225-33. 2009 [Epub ahead of print]. protein tyrosine kinase whose substrate is PtpA. Biochem J. 420:155-160.

Publication List Annual Report 2009 | 18

Yu H, Jiang X, Shen C, Karunakaran KP, Brunham Chow AW. Anaerobic infections. In: ACP Mills EJ, Peeri D, Cooper C, Nachega JB, Wung P, RC. Novel Chlamydia muridarum T cell antigens Medicine, Nabel EG (ed), American College of Tleyjeh I, Phillips P. Antifungal treatment for induce protective immunity against lung and Physicians, Philadelphia, Oct 2009 (http://www. invasive Candida infections: a mixed treatment genital tract infection in murine models. J acpmedicine.com/acpmedicine). comparison meta-analysis. Ann Clin Microb & Immunol. 2009; 182(3):1602-8. Antimicrob 2009;8:25. Reynolds SC, Chow AW. Severe soft tissue Brunham RC, Rekart ML. Considerations on infections of the head and neck: a primer for Pick, Dr. Neora Chlamydia trachomatis disease expression. critical care physicians. Lung 187:271-279. 2009. FEMS Immunol Med Microbiol. 2009; 55(2):162- Miller C, McMullin B, Ghaffari A, Stenzler A, Pick 6. Kalyan S, Chow AW. Linking innate and N, Roscoe D, Ghahary A, Road J, Av-Gay Y. adaptive immunity: human Vgamma9Vdelta2 Gaseous nitric oxide bactericidal activity Brunham RC. Infectious disease prevention and T cells enhance CD40 expression and HMGB-1 retained during intermittent high-dose control: remember 1908 and imagining 2108. secretion. Mediators.Inflamm. 2009: 819408, short duration exposure. Nitric Oxide. 2009 Can J Public Health. 2009; 100(1):5-8. 2009. Feb;20(1):16-23.

Pourbohloul B, Ahued A, Davoudi B, Meza R, Hmama, Dr. Zakaria Klein MB, Saeed S, Yang H, Cohen J, Conway B, Meyers L, Skowronski D, Villasenor I, Galvan F, Cooper C, Cote P, Cox J, Gill J, Haase D, Haider Cravioto P, Earn D, dushoff J, Fisman D, Edmunds Sun J, Lau AT, Wang X, Liao TA, Zoubeidi A, S, Montaner J, Pick N, rachlis A, Rouleau D, WJ, Hupert N, Scarpino S, Trujillo J, Lutzow M, Hmama Z. A Broad-Range of Recombination Sandre R, Tyndall M, Walmsley S. Cohort Profile: Morales J, Contreras A, Chavez C, Patrick D, Cloning Vectors in Mycobacteria, Plasmid 62: The Canadian HIV-Hepatitis C Co-infection Brunham RC. Initial human transmission 158-165, 2009. Cohort Study. Int J Epidemiol 2009 Sept. dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza and Other Respiratory Chao J, Wong D, Zheng X, Poirier V, Bach H, Reiner, Dr. Neil E. Viruses. 2009; 3(5):215-222. Hmama Z, Av-Gay Y. Protein kinases and phosphatases signaling in Mycobacterium Reiner NE (2009). Preface. Macrophages Cherkasov, Dr. Artem tuberculosis physiology and pathogenesis. BBA - and dendritic cells. Methods and Protocols. Proteins and Proteomics 1804:620-627, 2009. Methods Mol Biol. 531:v-vi. Thorsteinson N, Ban F, Santos-Filho O, Tabaei SM, Miguel-Queralt S, Underhill C, Cherkasov A Montessori, Dr. Valentina C. Lee JS, Reiner NE (2009). Stable lentiviral vector- (40%), Hammond GL. In silico identification of mediated gene silencing in human monocytic anthropogenic chemicals as ligands of zebrafish Mocroft A, Sterne JA, Egger M, et al, cell lines. Methods Mol Biol. 531:287-300. sex hormone binding globulin. Toxicol Appl Antiretroviral Therapy Cohort Collaboration Pharmacol. 2009; 234, 47-57. (ART-CC), Montessori, V (collaborator). Variable Rekart, Dr. Michael L. impact on mortality of AIDS-defining events Hormozdiari F, Salari R, Hsing M, Schönhuth A, diagnosed during combination antiretroviral Brunham, Robert C., Rekart, Michael L. Chan SK, Sahinalp SC, Cherkasov A. therapy: not all AIDS-defining conditions Considerations on Chlamydia trachomatis The effect of insertions and deletions on wirings are created equal. Clin Infect Dis 2009 Apr disease expression FEMS Immunology & in protein-protein interaction networks: a large- 14;48(8):1138-51. Medical Microbiology, Volume 55, Number 2, scale study. J Comput Biol. 2009 Feb;16(2):159- March 2009, pp. 162-166 (5). 67. Kesselring AM, Wit FW, Lundgren, et al. Nevirapine Toxicity Multicohort Collaboration. Hyeong- Jin Kim P, Petric M, Krajden M, Cherkasov A (30%), Hilpert K, Jenssen H, Fjell Montessori, V (collaborator). Risk factors for Isaac-Renton J, Ogilvie G, Rekart M. Trends of CD, Waldbrook M, Mullaly SC, Volkmer R, treatment-limiting toxicities in patients starting Anogenital HSV-1 and HSV-2 Infection in British Hancock RE. Use of Artificial Intelligence in the nevirapine-containing antiretroviral therapy. Columbia, 1997-2005. ISSTDR London, June 28 – Design of Small Peptide Antibiotics Effective AIDS 2009 Aug 24;23(13):1689-99. July 1, 2009. against a Broad Spectrum of Highly Antibiotic- Resistant Superbugs. ACS Chem Biol. 2009, 4, Phillips, Dr. Peter Mark Gilbert, MD, Michael L. Rekart, MD. 65-74. Recent trends in chlamydia and gonorrhea in Nunweiler C, Brown JA, Phillips P, Ellis J, Müller British Columbia. BCMJ, Vol. 51, No. 10, page F Hormozdiari, R. Salari, M. Hsing, A. Schonhuth, 435 December 2009. S.K. Chan, C.S. Sahinalp, A. Cherkasov (10%). N. The imaging features of non-tuberculous Mycobacterial immune reconstitution Effect on Insertions and Deletions (Indels) on Ogilvie GS, Taylor D, Moniruzzaman A, Knowles Wiring in Protein-Protein Interaction Networks: syndrome. J Comput Assist Tomogr 2009;33(2):242-6. L, Jones HD, Kim P, Rekart ML. (2009) A A Large-Scale Study. J. Comp. Biol., 2009, 16, 2, Population Based Study of Syphilis Re-infection 1-9. Galanis E, Hoang L, Kibsey P, Morshed M, in British Columbia, Canada over a Decade. Clin Infect Dis. 48(11):1154-1158. Fjell CD, Jenssen H, Hilpert K, Cheung WA, Panté Phillips P. Clinical presentation, diagnosis and management of Cryptococcus gattii cases: N, Hancock RE, Cherkasov A (25%). Jones H, Taylor D, Montgomery C, Patrick DM, Identification of novel antibacterial peptides by lessons learned from British Columbia. Can J Infect Dis Med Microbiol 2009:20(1);23-28. Money D. Vipond JC, Morshed M, Ruissard DA, chemoinformatics and machine learning. J Med Rekart ML. (2009) Prenatal and congenital Chem. 2009, 52, 2006-2015. Phillips P, Chapman K, Sharp M, Harrison P, syphilis in British Columbia. J Obstet Gynaecol Vortel J, Steiner T, Bowie W. Dexamethasone in Can. 27(5):467-247. Chow, Dr. Anthony W. Cryptococcus gattii central nervous system infection. CID 2009;49:591-5. Rekart ML. The Rise and Fall of Azrithromycin Chow AW: Deep neck space infections. In: for Sexually Transmitted Infections. BC Med J UpToDate, vol. 17, Basow DS (ed), Wolters Phillips P, Lee JK, Wang C, Yoshida E, Lima VD, 2009:51(5)195-196. Kluwer Health, Waltham, MA. Dec 2009 (http:// Montaner JSGM. Chylous ascites: a late www.uptodate.com). complication of intraabdominal Mycobacterium Ogilvie GS, Taylor DL, Moniruzzaman A, Knowles avium complex immune reconstitution L, Jones H, Kim P, Rekart ML. A population-based syndrome in HIV infected patients. Intl J STD & study of infectious syphilis rediagnosis in BC, AIDS Apr 2009;4(3):285-287. 1995-2005. Clinical Infectious Diseases 2009; 481554-8.

19 | Annual Report 2009 Publication List

Reynolds, Dr. Steven C. Milloy MJ, Kerr T, Zhang R, Tyndall M, Montaner Chlebowski R, Cuzick J, Amakye D, Bauerfeind I, J, Wood E. Inability to access addiction Buzdar A, Chia S, Cutuli B, Linforth R, Maass N, Keirs, HD, Litchfield A, Reynolds S, Griesdale D, treatment and risk of HIV infection among Noguchi S, robidoux A, Verma S and Hadji P. Gibney RT, Pickkers P, Chittock D, Sweet DD. injection drug users recruited from a supervised Clinical perspectives on the utility of aromatase Early goal-directed therapy of septic patients injection facility. J Public Health (Oxf). 2009 Sep inhibitors for the adjuvant treatment of breast coming from the ward does not protect the 23. [Epub ahead of print]. cancer. The Breast 2009;18 (S2):S1-S11. kidneys. Crit Care 2009, 13(Suppl 1):p259. Klein MB, Saeed S, Yang H, Cohen J, Conway B, Connors, Dr. Joseph M. Reynolds S, Chow A. Severe Soft Tissue Cooper C, Côté P, Cox J, Gill J, Haase D, Haider Infections of the Head and Neck: A primer S, Montaner J, Pick N, Rachlis A, Rouleau D, Cheung KJ, Shah SP, Steidl C, Johnson N, for Critical Care Physicians. Lung. 2009 Sep- Sandre R, Tyndall M, Walmsley S. Cohort Profile: Relander T, Telenius A, Lai B, Murphy KP, Lam W, Oct;187(5):271-9. Epub 2009 Aug 5. The Canadian HIV-Hepatitis C Co-infection Al-Tourah AJ, Connors JM, Ng RT, Gascoyne RD, Cohort Study. Int J Epidemiol. 2009 Sep 28. Horsman DE. Genome-wide profiling of follicular Steiner, Dr. Theodore S. [Epub ahead of print]. lymphoma by array comparative genomic hybridization reveals prognostically significant Phillips P, Chapman K, Sharp M, Harrison P, DNA copy number imbalances. Blood Vortel J, Steiner TS, Bowie W. Dexamethasone in MEDICAL ONCOLOGY 2009;113:137-48. Cryptococcal gattii Central Nervous System Infection. Clin. Infect. Dis. 2009 Aug; 49:591- Chia, Dr. Stephen K. Johnson NA, Boyle M, Bashashati A, Leach 595. S, Brooks-Wilson A, Sehn LH, Chhanabhai M, Au H, Golmohammadi, Younis T, Verma S, Chia S, Brinkman RR, Connors JM, Weng AP, Gascoyne Tyndall, Dr. Mark W. and Jacobs P. A Cost-Effectiveness Analysis of RD. Diffuse large B cell lymphoma: reduced Adjuvant Docetaxel, Adriamycin, and CD20 expression is associated with an inferior Grebaly J,Raffa J, Lai C, Krajden M, Kerr T, Fischer Cyclophosphamide (TAC) for Node-Positive survival. Blood 2009;113:3773-80. B, Tyndall M. Low uptake of treatment for Breast Cancer: Modeling the Downstream hepatitis C virus infection in a large community- Effects. Breast Cancer Res Treat 2009;114:579- Johnson NA, Leach S, Woolcock B, deLeeuw RJ, based study of inner city residents. J Viral Hepat. 87. Bashashati A, Sehn LH, Connors JM, Chhanabhai 2009 Feb 17. [Epub ahead of print]. M, Brooks-Wilson A, Gascoyne RD. CD20 Liu S, Chia S, Mehl E, Leung S, Rajput A, Cheang mutations involving the rituximab epitope Steenbeek A, Tyndall M, Sheps S, Rothenberg R. MCU and Nielsen TO. Progesterone receptor is a are rare in diffuse large B-cell lymphomas and An epidemiological survey of chlamydial and significant factor associated with clinical are not a significant cause of R-CHOP failure. gonococcal infections in a Canadian arctic outcomes and effect of adjuvant tamoxifen Haematologica 2009;94:423-7. community. Sex Transm Dis. 2009 Feb;36(2):79- therapy in breast cancer patients. Breast Cancer 83. Res Treat 2009 (published online Feb 10, 2009). Krzywinski MI, Schein JE, Birol I, Connors J, Gascoyne R, Horsman D, Jones SJ, Marra MA. Shannon K, Strathdee SA, Shoveller J, Rusch Chia S, Dent S, Ellard S, Ellis PM, Vandenberg T, Circos: An information aesthetic for comparative M, Kerr T, Tyndall MW. Structural and Gelmon K, Powers J, Walsh W, Seymour L and genomics. Genome Res 2009 epub. Environmental Barriers to Condom Use Eisenhauer EA, et al. Phase II trial of OGX-011 Negotiation With Clients Among Female Sex in Combination with Docetaxel in Metastatic Birol I, Jackman SD, Nielsen C, Qian JQ, Varhol R, Workers: Implications for HIV-Prevention Breast Cancer. Clin Cancer Res 2009;15:708-713. Stazyk G, Morin RD, Zhao Y, Hirst M, Schein JE, Strategies and Policy. Am J Public Health. 2009; Horsman DE, Connors JM, Gascoyne RD, Marra 99(4):659-65. Shaffer R, Tyldesley S, Rolles M, Chia S MA, Jones SJ. De novo Transcriptome Assembly and Mohamed I. Acute cardiotoxicity with with ABySS. Bioinformatics 2009;25:2872-7. Deering KN, Shannon K, Sinclair H, Parsad D, concurrent trastuzumab and radiotherapy Gilbert E, Tyndall MW. Piloting a peer-driven including internal mammary chain nodes: Campbell BA, Connors JM. Involved-node intervention model to increase access and A retrospective single institution study. radiotherapy for limited-stage Hodgkin adherence to antiretroviral therapy and HIV care Radiotherapy and Oncology 2009;90:122-126. lymphoma: Is it safe to reduce the radiotherapy among street-entrenched HIV-positive women field size? Amer J Hem Oncol 2009;8:284-287. in Vancouver. AIDS Patient Care STDS. 2009 Batist G, Gelmon KA, Chi KN, Miller WH, Chia S, Aug;23(8):603-9. et al. Safety, pharmacokinetics, and efficacy of Connors JM. Clinical manifestations and natural CPX-1 liposome injection in patients with history of Hodgkin’s lymphoma. Cancer Journal McInnes CW, Druyts E, Harvard SS, Gilbert advanced solid tumors. Clin Cancer Res 2009;15:124-128. M, Tyndall MW, Lima VD, Wood E, Montaner 2009;15:692-700. JS, Hogg RS.HIV/AIDS in Vancouver, British Schuetz JM, Spinelli JJ, Leach S, MacArthur A, Lai Columbia: a growing epidemic. Harm Reduct J. Ellard SL, Clemons M, Gelmon KA, Norris B, A, Gallagher RP, Connors JM, Gascoyne RD, 2009 Mar 5;6:5. Kennecke H, Chia S, Pritchard K, Eisen A, Brooks-Wilson AR. Genetic variation in the Vandenberg T, Taylor M, Sauerbrei E, Mishaeli NBS1, MRE11, RAD50 and BLM genes and Lloyd-Smith E, Wood E, Zhang R, Tyndall MW, M, Huntsman D, Walsh W, Olivo M, McIntosh susceptibility to non-Hodgkin lymphoma (NHL). Montaner JS, Kerr T. Determinants of cutaneous L and Seymour L. Randomized phase II study BMC Med Genet 2009;10:117. injection-related infection care at a supervised comparing two schedules of everolimus in injecting facility. Ann Epidemiol. 2009 patients with recurrent/metastatic breast Halaschek-Wiener J, Amirabbasi-Beik M, Jun;19(6):404-409. cancer: NCIC Clinical Trials Group IND.163. J Clin Monfared N, Pieczyk M, Sailer C, Kollar A, Oncol 2009;27:4536-43. Thomas R, Agalaridis G, Yamada S, Oliveira L, Kim C, Kerr T, Li K, Zhang R, Tyndall MW, Collins JA, Meneilly G, Marra MA, Madden KM, Montaner JS, Wood E.Unstable housing and Yerushalmi R, Hayes MM, Gelmon KA, Chia S, Le ND, Connors JM, Brooks-Wilson AR. Genetic hepatitis C incidence among injection drug users Bajdik C, Norris B, Speers C, Hassell P, O’Reilly variation in healthy oldest-old. PLoS One in a Canadian setting. BMC Public Health. 2009 SE, Allan S and Shenkier TN. A phase II study 2009;4:e6641. Jul 29;9:270. of neoadjuvant platinum regimen for locally advanced breast cancer: Pathologic response, longer term follow-up and correlation with biomarkers. Clin Breast Cancer 2009;9:166-172.

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Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah Gelmon, Dr. Karen A. Yerushalmi R. woods R, Kennecke H, Speers C, S, Woods R, Steidl C, Dyer MJ, Siebert R, Knowling M, Gelmon K. Patterns of relapse in Kuruvilla J, Klasa R, Connors JM, Gascoyne RD, Batist G, Gelmon KA, Chi KN, Miller WH Jr, Chia breast cancer: changes over time. Breast Cancer Horsman DE. Lymphomas with concurrent BCL2 SKL, Mayer LD, Swenson CE, Janoff AS, Louie Research and Treatment 2009; 120 (3): 753-759. and MYC translocations: the critical factors AC. Safety, Pharmacokinetics and Efficacy of associated with survival. Blood 2009;114:2273- CPX-1 (Irinotecan HCL: Floxuridine) Liposome Borugian MJ, Kan L, Poole B, Xu CL, St Germain 9. injection in patients with advanced solid tumors. L, Gelmon KA. The top issues patients mention Clinical Cancer Res 2009; 15(2): 692 -700. when family physicians recommend screening Savage KJ, Johnson NA, Ben-Neriah S, Connors mammography. BCMJ, 2009; 51(10): 436-439. JM, Sehn LH, Farinha P, Horsman DE, Gascoyne Courneya KS, Friedenreich CM, Reid RD, Gelmon RD. MYC gene rearrangements are associated K, Mackey JR, Ladha AB, Proulx C, Valllance Mackey J, Gelmon K, Martin M, McCarthy N, with a poor prognosis in diffuse large B-cell JK, Segal RJ. Predictors of follow-up exercise Pinter T, Rupin M, Youssoufin H. TRIO-012: a lymphoma patients treated with R-CHOP behaviour 6 months after a randomized trial multicentre, multinational randomized chemotherapy. Blood 2009;114:3533-7. of exercise training during breast cancer double blind phase II study of IMC-1121B plus chemotherapy. Breast Cancer Res Treat 2009: docetaxel versus placebo plus docetaxel in Farinha P, Al-Tourah A, Gill K, Klasa R, Connors 114 (1): 179- 87. previously untreated patient with HER2 negative JM, Gascoyne RD. The architectural pattern of unresectable and locally recurrent or metastatic FOXP3-positive T cells in follicular lymphoma Chia Stephen, Dent Susan, Ellard Susan, Ellis breast cancer. Clin Breast Cancer 2009; 9 (4): is an independent predictor of survival and Peter M, Vandenberg Ted, Gelmon Karen, 258 -61. histologic transformation. Blood 2009 115: Powers Jean, Walsh Wendy, Seymour Lesley, 289-295. Eisenhauer Elizabeth. Phase II trial of OGX 011 Gill, Dr. Sharlene in combination with docetaxel in metastatic Ellard, Dr. Susan L. breast cancer. Clin Cancer Research 2009; 15 (2); Schomas D, Miller R, Gill S, Quevedo F, Haddock 708 - 713. M and Donohue J etal. Intraperitoneal McArthur HL, Gelmon KA, Olivotto IA, Speers Treatment for Peritoneal Mucinous CH, Ellard SL, O’Reilly SE, Kennecke HF. The Mackey J, McLeod D, Ragaz J, Gelmon K, Verma Carcinomatosis of Appendiceal Origin After effectiveness of a letter notification program for S, Prichard K, Laing K, Provencher L, Operative Management: Long-term Follow-up of women with early stage breast cancer eligible Charbonneau LF. Cancer 2009; Epub ahead of the Mayo Clinic Experience, Annals of Surgery, for extended adjuvant letrozole. Journal of print. 249(4) April 2009 588-595. Clinical Oncology. 1388-1393. March 2009. Yerushalmi R, Kramer MR, Rizel S, Sulkes A, Van Cutsem E, Vervenne WL, Bennouna J, Ellard SL, Clemons MJ, Gelmon K, Norris BD, Gelmon K, Granot T, Neiman V, Stemmer SM. Humblet Y, Gill S, Van Laethem J, Verslype C, Kennecke HF, Chia SK, Pritchard KI, Eisen A, Decline in pulmonary function in patients Schiethauer W, Shang A, Cosaert J and Moore M Vandenberg T, Taylor M, Sauerbrei EE, Mishaeli with breast cancer receiving dose-dense Bevacizumab in Combination with Gemcitabine M, Huntsman D, Walsh WR, Olivo M, McIntosh chemotherapy: a prospective study. Ann Oncol and Erlotinib in Patients with Metastatic L, Seymour L. A Randomized phase II study 2009; 20 (3): 437-40. Pancreatic Cancer: A Randomized Phase III comparing two schedules of everolimus in Trial, Journal of Clinical Oncology, 2009 May patients with recurrent/metastatic breast Yerushalmi, R, Hayes M, Gelmon, K, Chia 1;27(13):2231-7. cancer; National Cancer Institute of Canada S, Bajdik, C, Norris, B, Speers C, Hassell P, Clinical Trials Group IND.163. Journal of Clinical O’Reilly S, Allan S, Shenkier, T. A Phase II trial Lim H, Gill S, Speers C, Melosky B, Barnett J, Oncology 27(27):4536-41, September 2009. of a neoadjuvant platinum regimen for locally Fitzgerald C, O’Reilly S and Kennecke H. Impact advanced breast cancer: Pathologic response, of Irinotecan and Oxaliplatin on Overall Survival Chia S, Dent S, Ellard S, Ellis PM, Vandenberg T, long term followup and correlation with in Patients with Metastatic Colorectal Cancer Gelmon K, Powers J, Walsh W, Seymour L, biomarkers. Clinical Breast Cancer 2009 Aug; (MCRC): a Population Based Study, Journal of Eisenhauer EA. Phase II Trial of OGX-011 in Vol. 9 (3), pp. 166-72. Oncology Practice, 5(4) July 2009, 153-8. combination with docetaxel in metastatic breast cancer. Clin Cancer Res. 15 708-713, 2009. Ellard SL, Clemons MJ, Gelmon K, Norris BC, Monzon J, Cremlin C, Armstrong L, Nuk J, Young Kennecke HF, Chia SK, Pritchard KI, Eisen A, S, Horsman D, Garbutt K, Bajdik C and Gill S, Fitzgerald, Dr. Catherine A. Vandenberg T, Taylor M, Sauerbrei EE, Mishaeli Validation of predictive models for germline M, Huntsman D, Walsh WR, Olivo M, McIntosh mutations in DNA mismatch repair genes in Lim H. J., Gill S., Speers C., Melosky B., Barnett L, Seymour L. A randomized Phase II study colorectal cancer’, International Journal of J., Fitzgerald C., O’Reilly S., Kennecke H. Impact comparing two schedules of everolimus in Cancer, 2009 August 3. of irinotecan and oxaliplatin on overall survival patients with recurrent/metastatic breast in patients with metastatic colorectal cancer: A cancer; NCIC CTG- IND 163. Jour Clin Oncol Chan T, Brown C, Ho C and Gill S. Primary population-based study. J Oncol Pract 2009; 2009; 27 (9): 1388-93. Tumour Resection in Metastatic Colorectal 5(4): 153-8. Cancer, American Journal of Oncology, 2009 Aug Yerushalmi R, Hayes M, Gelmon KA. Rare 21. Fretz, Dr. Eric Epithelial Breast Cancers. Annals of Oncology, 2009; 20 (11): 1763-70. 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21 | Annual Report 2009 Publication List

Hart, Dr. Jason Nichols CR, Kollmannsberger C: Clinical Claims Savage, Dr. Kerry J. from claims based data (letter). J Clin Oncol 27: E Carlotti, D Wrench, J Matthews, S Igbal, A e282-3, 2009. Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah Davies, A Norton, J Hart, R Lai, S Montoto, JG S, Woods R, Steidl C, Dyer MJS, Kurvilla K, Gribben, TA Lister, J Fitzgibbon. Transformation Lee, Dr. Christopher W. Klasa R, Connors JM, Gascoyne RD, Horsman DE. of follicular lymphoma to diffuse large B cell Lymphomas with concurrent BCL2 and MYC lymphoma may occur by divergent evolution Lee CW, Murray N, Anderson H, Rao SC, Bishop translocations: The critical factors associated form a common progenitor cell or by direct W. Outcomes with first-line platinum-based with survival. Blood. 2009 Sept 9; 114(11): evolution from the follicular lymphoma clone. combination chemotherapy for malignant 2273-9. July 13 2009 Epub. Blood 2009;113:3553-7. pleural mesothelioma: a review of practice in British Columbia. Lung Cancer 2009; 64: 308- Villa D, Connors JM, Shenkier TN, Gascoyne PT Truong, SO Jones, B Martens, C Alexander, M 313. RD, Sehn LH, Savage KJ Incidence and risk Paquette, H Joe, J Hart, SJ Allan. Treatment and factors for central nervous system relapse in outcomes in adult patients with primary cardiac Lee, Dr. Ursula J. patients with diffuse large B-cell lymphoma: The sarcoma: The British Columbia Cancer Agency impact of the addition of rituximab to CHOP Experience. Annals of Surgical Oncology. 2009; Lyly L, Kenneth S, Laurie Elit, Diane Procencher, chemotherapy. Annals of Oncology. Oct 27 Oct 15. (Epub ahead of print). Gavin Stuart, Tien Le, Ursula Lee, Angela 2009 (Epub) doi: 10.1093/annonc/mdp432. Rodgers, Gregory Pond, Amit Oza. “Phase II PT Truong, T Parhar, J Hart, C Alexander, ES Wai. multicentre open-label study of Carboplatin and Sehn, Dr. Laurie H. Population-based analysis of the frequency of Pegylated Liposomal Doxorubicin in Uterine and anemia and its management before and during Cervical Malignancies.” International Journal SavageJ, Johnson N, Ben-Neriah S, Connors JM, chemotherapy in patients with malignant of Gynecologic Oncology, Sep-Oct 2005 Vol Sehn LH, Farinha P, Horsman DE, Gascoyne RD. lymphoma. American Journal of Clinical 15(5),pp799-806. MYC gene re-arrangements are associated Oncology. 2009; Nov 22 (Epub ahead of print). with a poor prognosis in diffuse large B-cell Lê, Dr. Lyly H. lymphoma patients treated with R-CHOP Knowling, Dr. Margaret Anne (Meg) chemotherapy. Blood, epub September 2009. Michels J, Ellard SL, Le L, Kollmannsberger C, Yerushalmi R, Woods R, Kennecke H, Speers C, Murray N, Tomlinson Guns ES, Carr R, Chi KN. A Gratzinger D, Advani R, Zhao S, Talreja N, Knowling M, Gelmon K. Patterns of relapse in phase IB study of ABT-751 in combination with Tibshirani R, Shyam R, Horning S, Sehn L, Farinha breast cancer: changes over time. Breast Cancer docetaxel in patients with advanced castration- P, Briones J, Lossos IS, Gascoyne RD, Natkunam Res Treat. 2009 Aug 22. resistant prostate cancer. Ann Oncol. 2009 Jul Y. Lymphoma cell VEGFR2 expression detected 24. [Epub ahead of print]. by immunohistochemistry predicts poor overall Kollmannsberger, Dr. Christian survival in diffuse large B-cell lymphoma treated MacLean, Dr. Grant D. with immunochemotherapy (R-CHOP). British Heng DY, Xie W, Regan MM, Warren MA, Journal of Haematology, e-pub September 2009. Golshayan AR, Sahi C, Eigl B, Ruether JD, Del Vento, A., Bavelas, J., Healing, S., MacLean, Cheng T, North S, Venner P, Knox JJ, Chi KN, G., & Kirk, P. (2009). An experimental Johnson NA, Boyle M, Bashashati A, Leach Kollmannsberger C, McDermott DF, Oh WK, investigationof the dilemma of delivering bad S, Brooks-Wilson A, Sehn LH, Chhanabhai M, Atkins MB, Bukowski RM, Rini BI, and Choueiri news. Patient Education and Counseling, 77, Brinkman RR, Connors JM, Weng AP, Gascoyne TK: Prognostic factors for overall survival in 443-449. RD. Diffuse large B-cell lymphoma: reduced patients with metastatic renal cell carcinoma CD20 expression is associated with an inferior survival. Blood 113, 3773-80, 2009. treated with vascular endothelial growth factor Melosky, Dr. Barbara L. (VEGF)-targeted agents: Results from a large Johnson NA, Leach S, Woolcock B, deLeeuw RJ, retrospective multicenter study. J Clin Oncol Dec Melosky, B, Burkes, R, DRayson, Alcindor, T, 27: 5794-5799, 2009. Bashashati A, Sehn LH, Connors JM, Chhanabhai Shear, N, Lacouture, M. Management of skin M, Brooks-Wilson A, Gascoyne RD. CD20 rash during EGFR-targeted monoclonal antibody mutations involving the rituximab epitope Oechsle K, Bokemeyer C, Hartmann JT, treatment for gastrointestinal malignancies: Budach W, Trarbach T, Stahl M, Boehlke are rare in diffuse large B-cell lymphomas and Canadian recommendations. Current Oncology are not a significant cause of R-CHOP failure. I, Kollmannsberger C.: Four consecutive 2009;16,(1). multicenter phase II trials of adjuvant Haematologica 94, 423-7, 2009. chemoradiation in patients with completely Melosky, B Burkes, R; Rayson, D; Alcindor, T; resected high-risk gastric cancer: the experience Shustik J, Guangming H, Farinha P, Johnson N, Shear, N; Lacouture, M. Management of skin Connors JM, Sehn LH, Gascoyne RD, Steid C. of the German AIO/ARO/CAO group. J Cancer rash during EGFR-targeted monoclonal antibody Res Clin Oncol. 135:163-72, 2009. Outcome correlations of BCL6 rearrangement treatment for gastrointestinal malignancies: in diffuse large B cell lymphoma treated with Canadian recommendations. Curr Oncol . Heng DY, Chi KN, Murray N, Jin T, Garcia JA, CHOP or R-CHOP. Haematologica, Ocober 1, Volume: 16, Issue: 1, Date: 2009 Jan , Pages: 2009. Bukowski RM, Rini BI, Kollmannsberger C.: A 16-26. population-based study evaluating the impact of sunitinib on overall survival in the treatment Ellis, P M Morzycki, W; Melosky, B; Butts, C; Shenkier, Dr. Tamara N. of patients with metastatic renal cell cancer. Hirsh, V; Krasnoshtein, F; Murray, N; Shepherd, Cancer, e-pub ahead of print. F A; Soulieres, D; Tsao, M S; Goss, G. The role of Yerushalmi, R., M. M. Hayes, Gelmon, K. A. Chia, the epidermal growth factor receptor tyrosine S. Bajdik, C. Norris, B. Speers, C. Hassell, P. Kollmannsberger C, Moore C, Chi KN, Murray N, kinase inhibitors as therapy for advanced, O’Reilly, S. E, Allan, S. Shenkier, T. N et al. (2009). Daneshmand S, Gleave M, Hayes-Lattin B, metastatic, and recurrent non-small-cell “A phase II trial of a neoadjuvant platinum Nichols CR: Non-risk adapted Surveillance lung cancer: a Canadian national consensus regimen for locally advanced breast cancer: for Patients with Stage I nonseminomatous statement. Curr Oncol . Volume: 16, Issue: 1, pathologic response, long-term follow-up, and Testicular Germ Cell Tumors: Diminishing Date: 2009 Jan , Pages: 27-48 2009. correlation with biomarkers.” Clin Breast Cancer treatment-related morbidity while maintaining 9(3): 166-72. efficacy. Ann Oncol Oct 29 [Epub ahead of print] 2009.

Publication List Annual Report 2009 | 22

Villa, D., J. M. Connors, et al. (2009). “Incidence MEDICINE Simkus, Dr. Gerald J. and risk factors for central nervous system relapse in patients with diffuse large B-cell Ashton, Dr. Thomas Hamburger JN. Walsh SJ. Khurana R. Ding L. Gao lymphoma: the impact of the addition of M. Humphries KH. Carere R. Fung AY. rituximab to CHOP chemotherapy.” Ann Oncol. Ashton TH. Canadian Cardiovascular Society Mildenberger RR. Simkus GJ. Webb JG. Buller ( Advance Access published online on October CE. Percutaneous coronary intervention and 27, 2009). Consensus Conference Guidelines on Heart Failure, update 2009: Diagnosis and 30-day mortality: the British Columbia PCI Management of right sided heart failure, risk score.[see comment]. Catheterization & Swenerton, Dr. Kenneth D. myocarditis, device therapy and recent Cardiovascular Interventions. 74(3):377-85, important clinical trials. Secondary Panelist. Can 2009 Sep. McAlpine JN, Wiegand KW, Vang R, Ronnett BM, J Cardiol Vol. 25, No. 2, February 2009. Adamiak A, Koebel M, Kalloger SE, Swenerton Takaro, Dr. Timothy K. KD, Huntsman DG, Gilks CB, Miller DM. HER2 Cuff, Dr. Darcye overexpression and amplification is present in a Krieger JW, Takaro TK, Song L, Beaudet N, subset of ovarian mucinous carcinomas and can Madden KM, Lockhart C, Cuff D, Potter TF, Edwards K. The Seattle-King County Healthy be targeted with trastuzumab therapy. BMC Homes II Project: A Randomized Controlled Cancer 2009, 9, 433. Meneilly, GS. Short-term Aerobic Exercise Reduces Arterial Stiffness in Older Adults Trial of Asthma Self-Management Support with Type 2 Diabetes, Hypertension and Comparing Clinic-Based Nurses and In-Home Shah SP, Kobel M, Senz J, Morin R, Clarke B, Community Health Workers. Archives of Wiegand K, Leung G, Zayed AA, Mehl E, Kalloger Hypercholesterolemia. Published ahead of print at http://care.diabetesjournals.org June 9, Pediatrics & Adolescent Medicine 2009; 163: SE, Sun M, Guiliany R, Yorida E, Jones S, Varhol 141 - 149. R, Swenerton KD, Miller D, Clement PB, Crane C, 2009, doi: 10.2337/dc09-0149. Madore J, Provencher D, Leung P, DeFazio A, Roberts JW, Wallace LA, Camann DE, Dickey P, Khattra J, Turashvili G, Zhao Y, Zeng T, Glover Guzman, Dr. Jaime Gilbert SG, Le,wis RG, Takaro TK. Monitoring and JNM, Vanderhyden B, Zhao C, Parkinson C, Reducing Exposure of Infants to Pollutants Jimenez-Linan M, the Australian Ovarian Cancer Alamgir H, Yu S, Gorman E, Ngan K, Guzman J. in House Dust. Reviews of Environmental Study Group, Mes-Masson Anne-Marie, Brenton Near Miss and Minor Occupational Injury — Contamination and Toxicology . 2009, 201: 1-40. J, Aparacio SA, Boyd N, Hirst M, Gilks B, Marra Does It Share a Common Causal Pathway with M, Huntsman DG. Mutation of the FOXL2 gene Major Injury? Am J Ind Med. 2009 Jan;52(1):69- Subbarao PJ, Becker A, Brook J, Daley D, Miller in granulosa cell tumors of the ovary. N Engl J 75. Co-principal author. G, Mandhane P, Turvey S, Sears M, and CHILD Med 360;26, 2009. study investigators. Expert Review in Clinical Loisel P, Hong QN, Imbeau D, Lippel K, Guzman Immunology. 5;77-95. 2009. Mackay HJ, Tinker A, Winquist E, Thomas G, J, Maceachen E, Corbière M, Santos BR, Anema Swenerton K, Oza A, Sederias J, Ivy P, Eisenhauer JR. The work disability prevention CIHR strategic Uhlman S, Galanis E, Takaro TK, Mak S, EA. A phase II study of sunitinib in patients training program: program performance after 5 Gustafson L, Embree G, Bellack N, Corbett, K, with locally advanced or metastatic cervical years of implementation. J Occup Rehabil. 2009 Isaac-Renton J. Where’s the pump? Associating carcinoma: NCIC CTG Trial IND.184. Gynecol Mar;19(1):1-7. Co-principal author. sporadic enteric disease with drinking water Oncol 2009. using a Geographic Information System, in Alamgir H, Siow S, Yu S, Ngan K, Guzman J. British Columbia, Canada, 1996-2005. Water Tinker, Dr. Anna Compensation patterns for healthcare workers and Health 7:692-698. 2009. in British Columbia, Canada. Occup Environ Blaise Clarke, Anna V. Tinker, Chenghan Lee, Med. 2009 Jun;66(6):381-7. Co-principal author. Subbaya Subramanian, Matt van de Rijn, Dmitry NEPHROLOGY Turbin, Steve Kalloger, Mark G. Cadungog, David Guzman J. Neck pain and low-level laser: does Huntsman, George Coukos, and C. Blake Gilks. it work and how? Lancet. 2009 Nov 12. [Epub Intraepithelial T cells and Prognosis in Ovarian ahead of print]. Principal author. Gill, Dr. Jagbir Carcinoma: Novel Associations with Stage, Tumor Type and BRCA1 Loss. Mod Path 2009 Cabral DA, Uribe AG, Benseler S, O’Neil KM, Gill J, Shah T, Hristea I, Chavalithdamrong Mar;22(3):393-402. Hashkes PJ, Higgins G, Zeft AS, Lovell DJ, D, Anastasi B, Takemoto SK, Bunnapradist Kingsbury DJ, Stevens A, McCurdy D, Chira P, S. Outcomes of Simultaneous Heart Kidney Dariush Etemadmoghadam, Anna deFazio, Abramson L, rkachaisri T, Campillo S, Eberhard Transplant in the US: A Retrospective Analysis Rameen Beroukhim, Craig Mermel, Joshy A, Hersh AO, Huber AM, Kim S, Klein-Gitelman of the OPTN/UNOS Database. Am J Transplant. George, Gaddy Getz, Richard Tothill, Aikou M, Levy DM, Li SC, Mason T, Dewitt EM, 2009 Apr;9(4):844-52. Okamoto, Maria B Raeder, AOCS Study Group, Muscal E, Nassi L, Reiff A, Schikler K, Singer NG, Paul Harnett, Stephen Lade, Lars A Akslen, Wahezi D, Woodward A; ARChiVe (A Registry Young BY, Gill J, Huang E, Takemoto SK, Anastasi Anna Tinker, Bianca Locandro, Kathryn Alsop, for Childhood Vasculitis: e-entry)Investigators B, Shah T, Bunnapradist S. Living Donor Kidney Yoke-Eng Chiew, Nadia Traficante, Sian Fereday, Network. Classification, presentation, and versus Simultaneous Pancreas-Kidney Transplant Daryl Johnson, Stephen Fox, William Sellers, initial treatment of Wegener’s granulomatosis in Type I Diabetics: An Analysis of the OPTN/ Mitsuyoshi Urashima, Helga B Salvesen, in childhood. Arthritis Rheum. 2009 UNOS Database. Clin J Am Soc Nephrol 2009 Matthew Meyerson and David Bowtell. Nov;60(11):3413-24. Collaborator. Apr;4(4):845-52. Epub 2009 Feb 6. Integrated Genome-wide DNA Copy Number and Expression Analysis Identifies Distinct Klinke, Dr. Wolf P. Gill, Dr. John S. Mechanisms of Primary Chemo-resistance in Ovarian Carcinomas. Clin Cancer Res 2009 Feb Byrne J, Spence M, Fretz EB, Mildenberger R, Barraclough KA, Landsberg DN, Shapiro RJ, 15; 15 (4): 1417-27. Chase AJ, Berry B, Pi D, Janssen C, Klinke WP, Gill JS, Li G, Balshaw RF, Chailimpamontree Hilton JD. Body Mass Index, Periprocedureal W, Keown PA. A matched cohort Bleeding and Outcome Following Percutaneous pharmacoepidemilogical analysis of steroid free Coronary Intervention; Insights from the British immunosuppression in renal transplantation. Columbia Cardiac Registry. Am J Cardiol Transplantation. 2009 Mar 15;87(5):672-80. 2009;103:507-511. Provided input into data interpretation, and manuscript writing 10% contribution.

23 | Annual Report 2009 Publication List

Tonelli M, Klarenbach S, Wiebe N, Rose C, Gill JS. Yeates K, Wiebe N, Gill J, Sima C, Schaubel D, steroid free immunosuppression in renal Access to kidney transplantation among remote- Holland D, Hemmelgarn B, Tonelli M transplantation. Transplantation 2009; 87 (5); and rural-dwelling patients with kidney Similar outcomes among black and white renal 672-80. failure in the United States JAMA 2009 Apr allograft recipients. JASN. 2009 Jan;20(1):172-9. 22;301(16):1681-90. Designed and Oversaw Provided input into study design, analyses, Chailimpamontree W, Dmitrienko S, Li G, analyses, interpreted data, input in data interpretation and manuscript editing 0% Balshaw RF, Mahil A, Shapiro RJ, Landsberg writing and revision of manuscript. 33% contribution. DN, Gill J, Keown PA, and the Genome contribution. Canada Biomarkers in Transplantation Group. Landsberg, Dr. David N. Probability, predictors, and prognosis of post- Chailimpamontree W, Dmitrienko S, Li G, transplant glomerulonephritis. Journal of the Balshaw, Magil A, Shapiro RJ, Landsberg D, Gill J, Barraclough K, Landsberg D, Shapiro R, Gill J, Li Am Soc Neph 2009; 20 (4); 843-51. Keown PA. Probability, predictors and prognosis G, Balshaw R, Chailimpamontree W, Keown P. A of postransplantation glomerulonephritis. matched cohort pharmacoepidemiological Taylor, Dr. Paul JASN 2009 Apr;20(4):843-51. Contributed data, analysis of steroid free immunosuppression in interpreted analysis, revised manuscript. 10% renal transplantation. Transplantation 2009; Levin A, Schachter M, Zalunardo N, Taylor P, contribution. 87(5):672-680. Buller C, Duncan J, Rose C, Kiaii M, ‘Incidental Atherosclerotic Renal Artery Stenosis in Patients Tonelli M, Wiebe N, Hemmelgarn B, Klarenbach Clailimpamontree W, Dmitrienko S, Li G, Undergoing Elective Coronary Angiography: Are S, Field C, Manns B, Thadhani R, Gill J; Alberta Balshaw R, Magil A, Shapiro R, Landsberg D, Gill these lesions significant?’, Am J Neph , has been Kidney Disease Network. Trace elements in J, Keown P. Probability, predictors, and prognosis published online: Am J Nephrol 2009;29:434- hemodialysis patients: a systematic review and of post transplantation glomerulonephritis. 439. meta-analysis. BMC Medicine. 2009 May 19; Journal of the American Society of Nephrology 7-25. Provided input into data interpretation, 2009; 20(4):843-851. and manuscript writing. 10% contribution. NEUROLOGY Levin, Dr. Adeera Kim SJ, Gill JS. H-Y Incompatability Predicts Anderson, Dr. Duncan P. Short Term Outcomes For Kidney Transplant Lee D, Levin A, McMahon L, Roger S, Recipients. J Am Soc Nephrol. 2009 June 18; “Longitudinal analysis of performance of Epub ahead of print. Provided input into study Seth A, Anderson, DP, Albiani D, Barton JJS. estimated glomerular filtration rate as renal Orbital inflammation and optic neuropathy with design, data interpretation and manuscript function declines in chronic kidney disease”, writing and revision. 35% contribution. zoledronic acid for metastatic prostate cancer. NDT 2009 Jan; 24: 109-16. Can J Ophthalmol 2009; 44: 467-8. Bromberg J, Gill J. Heavy LYFTing: KASting pearls Levin A, Schachter M, Zalunardo N, Taylor P, before swine. Am J Transplant. 2009 Buller C, Duncan J, Rose C, Kiaii M, ‘Incidental Barton, Dr. Jason J. Jul;9(7):1489-90. Revised original draft and Atherosclerotic Renal Artery Stenosis in Patients edited manuscript. 40% Contribution. Undergoing Elective Coronary Angiography: Fox CJ, Moon S-Y, Iaria G, Barton JJS. The Are these lesions significant?’, Am J Nephrol correlates of subjective perception of identity Gill JS, Zalunardo N, Rose C, Tonelli M. The 2009;29:434-9. and expression in the face network: an fMRI pregnancy rate and live birth rate in kidney adaptation study. Neuroimage 2009; 44: 569-80. transplant recipients. Am J Transplant. 2009 Komenda P, Chan C, Pauly RP, Levin A, Copland July;9(7): 1541-9. Conceived study, oversaw M, Pierratos A, Sood MM,”The Evaluation of a Iaria G, Bogod N, Fox CJ, Barton JJS. Congenital analysis, interpreted data, wrote manuscript, successful home hemodialysis program: topographical disorientation: case one. corresponding author. 60% contribution. establishing a prospective framework for Neuropsychologia 2009; 47: 30-40. quality”, Clinical Nephrology 2009 Jan; Vol 71, Iordanous Y, Seymour N, Young A, Johnson J, pp. Iaria G, Palermo L, Committeri G, Barton.JJS. Age Iansavichus AV, Cuerden MS, Gill JS, Poggio E, differences in the formation and use of cognitive Garg AX; for the Donor Nephrectomy Outcomes Sigrist M, Chiarelli G, Lim L, Levin A, “Early maps. Behav Brain Res 2009; 196: 187-91. Research (DONOR) Network. Recipient Initiation of Phosphate Lowering Dietary outcomes for expanded criteria living donors: Therapy in Non-Dialysis Chronic Kidney Disease: Fox CJ, Iaria G, Barton JJS. Defining the face- The disconnect between current evidence and A Critical Review”, Journal of Renal Care 2009 processing network: optimization of the practice. Am J Transplant. 2009 July;9(7):1558- Mar; 35 (s1), pp71-8. functional localizer in fMRI. Human Brain Mapp 73. Provided input into study design, data 2009; 30: 1637-51. interpretation, and manuscript writing. 10% Levin A, “Predicting Outcomes in CKD: the contribution. Importance of Perspectives, Populations and Barton JJS. What is meant by impaired Practices”, NDT 2009 Advance Access Published. configural processing in acquired Kiberd B, Rose C, Gill JS. Cancer Mortality in prosopagnosia? Perception 2009; 39: 242-60. Kidney Transplant Recipients. Am J Transplant. Rigatto C, Levin A, House A, Barrett B, Carlisle E, 2009 August;9(8):1868-75. Designed and Fine A, “Atheroma Progression in Chronic Kidney Rodriguez AR, Egan R, Barton JJS. Paroxysmal oversaw analysis, interpreted data, input Disease”, CJASN 2009 Feb; Vol 4, No. 2, pp291-8. ocular tilt reaction. Neurology 2009; 72: e67-8. into writing and revision of manuscript. 30% contribution. Lanyon LJ, Giaschi D, Young SA, Fitzpatrick K, Shapiro, Dr. R. J. Diao L, Rasool N, Bjornson BH, Barton JJS. Pauly R, Gill JS, Rose C, Reem A., Chery A, Combined functional MRI & diffusion tensor Pierratos A, Chan CT. Survival among nocturnal Dmitrienko S, Balshaw R, Machnicki G, Shapiro imaging analysis of extrastriate cerebral motion home hemodialysis patients compared to RJ, Keown PA. Probabilistic modeling of CMV pathways. J Neuroophthalmol 2009; 29: 96-103. kidney transplant recipients. Nephrology Dial infection under consensus clinical management Transplantation. 2009 Sept;24(9):2915-9. guidelines. Transplantation 2009; 87 (4); 570- Polli FE, Wright CI, Milad MR, Dickerson BC, Oversaw study design, all aspect of statistical Vangel M, Barton JJS, Rauch SL, Manoach DS. analysis, review and edit of manuscript. 25% Barraclough KA, Landsberg DN, Shapiro RJ, Hemispheric differences in amygdala contribution. Gill JS, Li G, Balshaw RF, Chailimpamontree W, contributions to response monitoring. Keown PA, for the Genome Canada Biomarkers Neuroreport 2009; 20: 398-402. in Transplantation Group. A matched cohort pharmacoepidemiological analysis of Publication List Annual Report 2009 | 24

Foulsham T, Barton JJS, Kingstone A, Dewhurst Briemberg, Dr. Hannah transporter relation to levodopa-derived R, Underwood G. Fixation and saliency during synaptic dopamine in a rat model of Parkinson’s: search of natural scenes: the case of visual Richardson PG, Xie W, Mitsiades C, Chanan-Khan an in-vivo imaging study. J Neurochem. 109: agnosia. Neuropsychologia 2009; 47:1994-2003. AA, Lonial S, Hassoun H, Avigan DE, Oaklander 85-92. AL, Kuter DJ, Wen PY, Kesari S, Briemberg, HR, Dalrymple KA, Bischof W, Cameron D, Schlossman RL, Munshi NC, Heffner LT, Doss D, Santos-Garcia D, Abella J, De Domingo B, Barton JJS, Kingstone A. Global perception in Esseltine DL, Weller E, Anderson KC, Amato AA. de la Fuente-Fernandez R (2009). Leber simultanagnosia is not as simple as a game of Single-agent bortezomib in previously untreated hereditary optic neuropathy associated with connect-the-dots. Vision Res 2009; 49: 1901-8. multiple myeloma: efficacy, characterization malabsorption syndrome after bariatric surgery. of peripheral neuropathy, and molecular J Neuroophthalmol. 29: 75-76. Seth A, Anderson DP, Albiani D, Barton JJS. correlations with response and neuropathy. Orbital inflammation and optic neuropathy with Journal of Clinical Oncology 2009;27(21):3518- Troiano AR, de la Fuente-Fernandez R, Sossi zoledronic acid for metastatic prostate cancer. 3525. V, Schulzer M, Mak E, Ruth TJ, Stoessl AJ Can J Ophthalmol 2009; 44: 467-8. (2009). PET demonstrates reduced dopamine Qasem A, Tanha F, Briemberg, HR. Diabetic transporter expression in PD with dyskinesias. Guo M, Oruç I, Barton JJS. Cross-orientation Muscle Infarction. Can.J.Neurol.Sci. Neurology. 72: 1211-1216. transfer of adaptation for facial identity is 2009:36;651-653. asymmetric: A study using contrast-based Santos-Garcia D, Llaneza M, Macias M, de la recognition thresholds. Vision Res 2009; 49: Briemberg, HR. Peripheral nerve complications Fuente-Fernandez R (2009). Multiple craneal 2254-60. of medical disease. Seminars in Neurology neuropathy associated with herpes simplex 2009:29(2);124-135. virus infection and anti-GM2 immunoglobulin M Rostamirad S, Barton JJS, Oruç I. Center- antibodies. J Clin Neuromuscul Dis. 10: 199-201. surround organization of face-space: evidence Cashman, Dr. Neil R. from contrast-based face-priming. Neuroreport Nandhagopal R, Kuramoto L, Schulzer M, Mak E, 2009; 20: 1177-82. Li L, Guest W, Huang A, Plotkin S, Cashman Cragg J, Lee CS, McKenzie J, McCormick S, NR. Immunological mimicry of PrPC-PrPSc Samii A, Troiano A, Ruth TJ, Sossi V, de la Fuente- Barton JJS, Fox CJ, Sekunova A, Iaria G. interactions: Antibody-induced PrP misfolding. Fernandez R, Calne DB, Stoessl AJ (2009). Encoding in the visual word form area: an fMRI- Protein Engineering, Design and Selection, Longitudinal progression of sporadic Parkinson’s adaptation study of words versus handwriting. J Protein Eng Des Sel. 2009 Aug;22(8):523-9. disease: a multi-tracer positron emission Cogn Neurosci 2009; epub Jul 6. tomography study. Brain.132: 2970-9. Haddon JD, Hughes MR, Antignano F, David Lee H, Abegg M, Rodriguez A, Koehn JD, Barton Westaway D, Cashman NR, McNagny KM. Prion Santos-García D, Cabanillas M, Suarez-Dono I, JJS. Why do subjects make antisaccade errors? protein is expressed on mast cells and is Monteagudo B, de la Fuente-Fernandez R, Exp Brain Res 2009; epub Sep 17. released upon their activation. The Journal of Suarez-Amor O (2009). [Type 1 Infectious Diseases, 2009 Sep 1;200(5):827-31. neurofibromatosis and Arnold-Chiari Barton JJS, Hanif H, Ashraf S. Relating visual to malformation]. Actas Dermosifiliogr. 100: 820-2. verbal semantic knowledge: the evaluation of Wong M, Toth J, Haney S, Toth, Tyshenko MG, Spanish. object recognition in prosopagnosia. Brain 2009; Darshan S, Krewski D, Leighton FA, Westaway D, epub Oct 5. Moore SS, Ricketts M, Cashman NR. PrioNet Devonshire, Dr. Virginia A. Canada: A Network of Centres of Excellence for Scheel M, Abegg M, Lanyon LJ, Mattman A, Research into Prions and Prion Diseases. Journal Tremlett H, Zhao Y, Devonshire, V; UBC Barton JJS. Eye movement and diffusion tensor of Toxiocology and Environmental Health Neurologists.Natural history comparisons of imaging analysis of treatment effects in a 2009;72(17):1000-7. primary and secondary progressive multiple Niemann Pick Type C patient. Mol Genet Metab sclerosis reveals differences and similarities. J 2009; epub Oct 30. Hedlin PD, Cashman NR, Li L, Gupta J, Babiuk LA, Neurol. 2009 Mar;256(3):374-81. Potter AA, Griebel P, Napper S. Design and Iaria G, Fox CJ, Scheel M, Stowe RM, Barton JJS delivery of a cryptic PrP(C) epitope for induction Tremlett H, Yousefi M, Devonshire, V, Rieckmann (2009). A case of persistent visual hallucinations of PrP(Sc)-specific antibody responses. Vaccine. P, Zhao Y; UBC Neurologists. Impact of multiple of faces following LSD abuse: A functional 2009. sclerosis relapses on progression diminishes magnetic resonance imaging study. Neurocase, with time. Neurology. 2009 Nov 17;73(20):1616- November 18:1-13. Cashman N, Darshan S, Krewski D, Tyshenko 23. MG.Prion research in perspective. Preface. J Iaria, G., Bogod, N., Fox, C. J., & Barton, Toxicol Environ Health A. 2009;72(17):999. Doudet, Dr. Doris J. JJS (2009). Developmental Topographical Disorientation: Case One. Neuropsychologia, Chapman, Dr. Kristine M. Sossi, K. Dinelle, R. de la Fuente-Fernandez, AJ 47(1), 30-40. Stoessl, G.J. Topping, J.E. Holden, M Schulzer, TJ Sayao AL, Heran MK, Chapman, K, Redekop Ruth, Doudet, D. Dopamine transporter relation Bogod, Dr. Nicholas M. G, Foti D. Intracranial hypotension causing to levodopa-derived synaptic dopamine in a rat reversible frontotemporal dementia and coma. model of Parkinson’s: an in-vivo imaging study. Iaria G, Bogod N, Fox CJ & Barton JJ. (2009). Can J Neurol Sci. 2009 Mar;36(2):252-6. J. Neurochemistry. 109:85-92 (2009). Developmental topographical disorientation: Case one. Neuropsychologia, 47(1), 30-40. De la Fuente-Fernandez, Dr. Raul Feldman, Dr. Howard H. Iaria G, Bogod, N, Fox CJ, Barton JJS. Congenital de la Fuente-Fernandez R, Sossi V, McCormick Davidson JE, Irizarry MC, Bray BC, Wetten topographical disorientation: case one. S, Galwey N, Gibson R, Borrie M, Delisle R, Neuropsychologia 2009; 47:30-40. S, Schulzer M, Ruth TJ, Stoessl AJ (2009). Visualizing vesicular dopamine dynamics in Feldman, HH, Hsiung G-Y, Fornazzari L, Gauthier Parkinson’s disease. Synapse. 63: 713-716. S, Guzman D, Loy-English I, Keren R, Kertesz A, St. George-Hyslop P, Wherrett J, and Monsch Sossi V, Dinelle K, Topping GJ, Holden JE, Doudet AU. An exploration of cognitive subgroups in D, Schulzer M, TJ Ruth TJ, Stoessl AJ, de la Alzheimer’s Disease. Journal of the International Fuente-Fernandez R (2009). Dopamine Neuropsychological Society 2009 Dec4: 1-11 [epub ahead of print].

25 | Annual Report 2009 Publication List

Moorhouse P, Song X, Rockwood K, Black S, Feldman, HH, Pirttila T, Dartigues JF, Everitt B, An exploration of cognitive subgroups in Kertesz A, Gauthier S, and Feldman, HH, on Van Baelen B, Brashear HR, Berlin J, Battisti W Alzheimer’s disease. J Int Neuropsychol Soc. behalf of the Consortium to Investigate Vascular and Kavanagh S. Analyses of mortality risk in 2009 Dec 4:1-11. Impairment of Cognition. Executive dysfunction dementia patients treated with galantamine. in vascular cognitive impairment in the Acta Neurologica Scandinavica 2009; 119(1): Illes, Dr. Judy consortium to investigate vascular impairment 22-31. of cognition study. Journal of the Neurological Tairyan, K., Illes, J. Imaging genetics and the Sciences [Epub ahead of print October 17, Foti, Dr. Dean J. power of combined technologies: A perspective 2009]. from neuroethics. Neuroscience, 2009, Epub Sayao AL, Heran MK, Chapman K, Redekop ahead of print. Woodward M, Black S, Jacova C, Kertesz A, G, Foti, D. Intracranial hypotension causing Mackenzie IR, Feldman, HH and the ACCORD reversible frontotemporal dementia and coma. Crawley, L.M., Illes, J. Direct-to-consumer Investigator Group. Differentiating the frontal Can J Neurol Sci. 2009 Mar;36(2):252-6. advertising in black and white: Racial differences variant of Alzheimer’s Disease. International in placement patterns of print advertisements Journal of Geriatric Psychiatry 2009 [Epub ahead Gibson, Dr. Gillian M. for health products and messages. Health of print October 12, 2009]. Marketing Quarterly, 2009, 27(2). Merkies IS, Bril V, Dalakas MC, Deng C, Donofrio Jones RW, Schwam E, Wilkinson D, Waldemar G, P, Hanna K, Hartung HP, Hughes RA, Latov N, Singh, J., Illes, J., Lazzeroni, L., Hallmayer, J. Feldman, HH, Zhang R, Albert K, and Schindler R. van Doorn PA; ICE Study Group. “Health- Clinical and research trends in autism. Journal Rates of Cognitive Change in Alzheimer’s related quality-of-life improvements in CIDP of Autism and Developmental Disorders, 2009, Disease: Observations Across a Decade with immune globulin IV 10%:the ICE Study” Epub ahead of print. of Placebo Controlled Clinical Trials With Neurology. 2009 Apr 14;72(15):1337-44. Donepezil. Alzheimer’s Disease & Associated Lau, P.W., Illes, J. The gray zones of privatized Disorders 2009; 23(4): 357-364. McMaster J. Gibson, G. Castro_Prado F. Honey imaging. American Journal of Bioethics - CR. ”Neurosurgical treatment of tremor in Neuroscience, 2009, Epub ahead of print. Wilkinson D, Schindler R, Schwam E, Waldemar anti-myelin-associated glycoprotein G, Jones R, Gauthier S, Lopez OL, Cummings neuropathy”. Neurology 73 (20) 1707-8, 2009 Illes, J, Lombera, S. Identifiable neuro ethics J, Xu Y, and Feldman, HH. Effectiveness of Nov 17. challenges to the banking of neuro data. Donepezil in Reducing Clinical Worsening in Minnesota Journal of Law, Science and Patients with Mild-to-Moderate Alzheimer’s Technology, 2009, 10(1):71-94. Disease. Dementia & Geriatric Cognitive Hashimoto, Dr. Stanley A. Disorders 2009; 28(3): 244-251. Ball NJ, Cowan B, Hashimoto, SA. Lobules Tairyan, K., Illes, J. Imaging genetics and the power of combined technologies: A perspective Lanctot KL, Hsiung G-YR, Feldman, HH, Masoud panniculitis at site of subcutaneious beta interferon injections for multiple sclerosis can from neuroethics. Neuroscience, 2009, 164(1):7- ST, Sham L, and Herrmann N. Assessing the 15. validity of deriving Clinical Dementia Rating histologically mimic pancreatic panniculitis. (CDR) Global scores from independently- A study of 12 cases. Journal of Cutaneous Pathology 2009. 36:331-337. Crawley, L.M., Illes, J. Direct-to-consumer obtained Functional Rating Scale (FRS) scores in advertising in black and white: Racial differences vascular dementia with and without Alzheimer’s Hashimoto, SA, Ball NJ, Tremlett H. Progressive in placement patterns of print advertisements disease. International Journal of Geriatric for health products and messages. Health Psychiatry 2009; 24(10):1174-1176. lipoatrophy after cessation of glatiramer acetale injections; a case report. Multiple Sclerosis Marketing Quarterly, 2009, 26(4):279-92. 2009; 15:521-22. Ferris S, Lane R, Sfikas N, Winblad B, Farlow M, Singh, J., Illes, J., Lazzeroni, L., Hallmayer, J. and Feldman, HH. Effects of gender on response Trends in US Autism Research Funding. Journal to treatment with rivastigmine in mild cognitive Hooge, Dr. John P. of Autism and Developmental Disorders, 2009, impairment: A post hoc statistical modeling 39(5):788-95. approach. Gender Medicine 2009; 6(2): 345- Pfeffer G, Prout A, Hooge, J, Maguire J. Biopsy- 355. proven immune reconstitution syndrome in a Lau, P.W., Illes, J. The gray zones of privatized patient with AIDS and cerebral toxoplasmosis. imaging. American Journal of Bioethics – Kandiah N and Feldman, HH. Therapeutic Neurology 2009;73:321-322. Neuroscience, 2009, 9(4):21-2. potential of statins in Alzheimer’s disease. Journal of the Neurological Sciences 2009; Hsiung, Dr. Ging-Yuek R. Racine, E., Iles, J., Lansberg, M.G., Dion, M.J., 283(1-2): 230-234. Wijman, C. Profiles of neurological outcome Lanctôt K, Hsiung, GYR. , Feldman HH, Masoud prediction among intensivists. Neurocritical Brooks BL, Iverson GL, Feldman, HH, and ST, Sham L, Herrmann N. Assessing the validity Care, 2009, 11(3):345-52. Holdnack JA. Minimizing misdiagnosis: of deriving Clinical Dementia Rating (CDR) Psychometric criteria for possible or probable Global scores from independently-obtained Caulfield, T., Zarzeczny, A., McCormick, J., memory impairment. Dementia & Geriatric Functional Rating Scale (FRS) scores in vascular Bubela, T., Critchley, C., Einsiedel, E., Galipeau, Cognitive Disorders 2009; 27(5): 439-450. dementia with and without Alzheimer’s disease. J., Harmon, S., Huynh, M., Hyun, I., Illes, J., Isasi, International Journal of Geriatric Psychiatry. R., Joly, Y., Laurie, G., Lomax, G., Longstaff, H., Feldman, HH, Pirttila T, Dartigues JF, Everitt B, 2009 Oct;24 (10):1174-6. McDonald, M., Murdoch, C., Ogbogu, U., Van Baelen B, Schwalen S, and Kavanagh S. Owen-Smith, J., Pattinson, S., Premji, S., Treatment with galantamine and time to nursing Puangthong U & Hsiung, GYR. Critical appraisal von Tigerstrom, B., Winickoff, D.E. The Stem home admission in Alzheimer disease patients of the long-term impact of memantine in Cell Research Environment: A Patchwork of with and without cerebrovascular disease. treatment of moderate to severe Alzheimer’s Patchworks. Stem Cell Reviews and Reports, International Journal of Geriatric Psychiatry disease. Neuropsychiatric Disease and 2009, 5(2):82-8. 2009; 24(5): 479-488. Treatment 2009;5:553-561. Illes, J. Neurologisms. American Journal of Feldman, HH and Jacova C. Predicting treatment Davidson JE, Irizarry MC, Bray BC, Wetten Bioethics. 2009, (9)9: 1. response to acetylcholinesterase inhibitor S, Galwey N, Gibson R, Borrie M, Delisle R, treatment in Alzheimer disease: has the time Feldman HH, Hsiung, GY, Fornazzari L, Gauthier come? Nature Clinical Practice Neurology 2009; S, Guzman D, Loy-English I, Keren R, Kertesz A, 5(3):128-129. George-Hyslop PS, Wherrett J, Monsch AU. Publication List Annual Report 2009 | 26

Illes, J., Borgelt, E. Incidental findings: In practice Kim JY, Kim EH, Kim, SU, Kwon TK, Choi KS. Lee HJ, Park IH, Kim HJ, Kim, SU. Human neural and in person. Nature Reviews Neurology. Capsaicin sensitizes malignant glioma cells to stem cells overexpressing glial cell line-derived December 2009. 5:643-644. TRAIL-mediated apoptosis via DR5 upregulation neurotrophic factor in experimental cerebral and survivin down regulation. Carcinogenesis. hemorrhage. Gene Ther. 2009 Sep;16(9):1066- Caulfield, T., Zarzeczny, A., McCormick, J., 2009 Nov 25. [Epub ahead of print]. 76. Bubela, T., Chritchley, C., Einsiedel, E., Galipeau, J., Harmon, S., Huynh, M., Hyun, I., Illes, J., Isasi, Ito S, Natsume A, Shimato S, Ohno M, Kato T, Lee SI, Kim BG, Hwang DH, Kim HM, Kim, SU. R., Joly, Y., Laurie, G., Lomax, G., Longstaff, H., Chansakul P, Wakabayashi T, Kim, SU. Human Overexpression of Bcl-XL in human neural stem McDonald, M., Murdoch, C., Ogbogu, U., neural stem cells transduced with IFN-beta and cells promotes graft survival and functional Owen-Smith, J., Pattinson, S., Premji, S., von cytosine deaminase genes intensify bystander recovery following transplantation in spinal cord Tigerstrom, B., Winickoff, D.E. International stem effect in experimental glioma. Cancer Gene injury. J Neurosci Res. 2009 Nov 1;87(14):3186- cell environments: A world of difference. Nature Ther. 2009 Nov 6. [Epub ahead of print]. 3197. Reports Stem Cells, 2009. Wakabayashi K, Nagai A, Sheikh AM, Shiota Y, Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno Jacova, Dr. Claudia Narantuya D, Watanabe T, Masuda J, Kobayashi M, Kato T, Chansakul P, Ito M, Kim, SU, S, Kim, SU, Yamaguchi S. Transplantation of Wakabayashi T. Induction of oligodendrogenesis Feldman, H., Jacova, C. Predicting response human mesenchymal stem cells promotes in glioblastoma-initiating cells by IFN-mediated to acetylcholinesterase inhibitor treatment in functional improvement and increased activation of STAT3 signaling. Cancer Lett. 2009 Alzheimer disease: Has the time come? Nat Clin expression of neurotrophic factors in a rat focal Oct 18;284(1):71-79. Pract Neurol 2009 Feb 3 [Epub ahead of print]. cerebral ischemia model. J Neurosci Res. 2009 Nov 2. [Epub ahead of print]. Lee HJ, Kim MK, Kim HJ, Kim, SU. Human neural Woodward, M., Jacova, C., Black, S., Kertesz, A., stem cells genetically modified to overexpress Mackenzie, I., Feldman, H. Differentiating the Satoh JI, Obayashi S, Tabunoki H, Wakana T, Kim, Akt1 provide neuroprotection and functional frontal variant of Alzheimer Disease. SU. Stable Expression of Neurogenin 1 Induces improvement in mouse stroke model. PLoS One. International Journal of Geriatric Psychiatry LGR5, a Novel Stem Cell Marker, in an 2009;4(5):e5586. Epub 2009 May 18. 2009, Oct 12 [Epub ahead of print]. Immortalized Human Neural Stem Cell Line HB1. F3. Cell Mol Neurobiol. 2009 Oct 8. [Epub ahead Song M, Kim Y, Kim Y, Ryu S, Song I, Kim, SU, Javidan, Dr. Manouchehr of print]. Yoon BW. MRI tracking of intravenously transplanted human neural stem cells in rat R. Al Roughani, M. Javidan, N. Al-Otaibi, A Frank RT, Edmiston M, Kendall SE, Najbauer J, focal ischemia model. Neurosci Res. 2009 Qasem. Prevalence of non-convulsive status Cheung CW, Kassa T, Metz MZ, Kim, SU, Glackin Jun;64(2):235-239. epilepticus in patients with impaired level of CA, Wu AM, Yazaki PJ, Aboody KS. Neural stem consciousness. CJNS: Vol 33, Suppl. 2, May 2007. cells as a novel platform for tumor-specific An JH, Lee SY, Jeon JY, Cho KG, Kim, SU, Lee MA. delivery of therapeutic antibodies. PLoS One. Identification of gliotropic factors that induce Editorial: M. Javidan: Investigations for syncope. 2009 Dec 15;4(12):e8314. human stem cell migration to malignant tumor. J Role of EEG and the Specialty of the Ordering Proteome Res. 2009 Jun;8(6): 2873-2881. Physician; Can. J . Neurol. Sci. Vol. 36, No. 6, Thu MS, Najbauer J, Kendall SE, Harutyunyan Nov. 2009. I, Sangalang N, Gutova M, Metz MZ, Garcia Kim HM, Hwang DH, Lee JE, Kim, SU, Kim BG. Ex E, Frank RT, Kim, SU, Moats RA, Aboody KS. vivo VEGF delivery by neural stem cells Alroughani, M. Javidan, A. Qasem, N. Alotaibi. Iron labeling and pre-clinical MRI visualization enhances proliferation of glial progenitors, Non-Convulsive status epilepticus; the rate of of therapeutic human neural stem cells in a angiogenesis, and tissue sparing after spinal occurrence in a general hospital. Seizure 18 murine glioma model. PLoS One. 2009 Sep cord injury. PLoS One. 2009;4(3):e4987. Epub (2009) pages 38-42. 29;4(9):e7218. 2009 Mar 25. Hwang DH, Kim BG, Kim EJ, Lee SI, Joo IS, Suh- Kim, SU, de Vellis J. Stem cell-based cell therapy Kim, Dr. Seung U. Kim H, Sohn S, Kim, SU. Transplantation of in neurological diseases: a review. J Neurosci human neural stem cells transduced with Res. 2009 Aug 1;87(10):2183-2200. Obayashi S, Tabunoki H, Kim SU, Satoh JI. Gene Olig2 transcription factor improves locomotor expression profiling of human neural progenitor recovery and enhances myelination in the white Kim SY, Cho HS, Yang SH, Shin JY, Kim JS, Lee ST, cells following the serum-induced astrocyte matter of rat spinal cord following contusive Chu K, Roh JK, Kim, SU, Park CG. Soluble differentiation. 2009 Jan 6, [Epub ahead of injury. BMC Neurosci. 2009 Sep 22;10:117. mediators from human neural stem cells play print]. a critical role in suppression of T-cell activation Lee DH, Ahn Y, Kim, SU, Wang KC, Cho BK, Phi and proliferation. J Neurosci Res. 2009 Aug Joo K, Park IH, Shin JY, Jin J, Kang BG, Kim SY, Kim JH, Park IH, Black PM, Carroll RS, Lee J, Kim 1;87(10):2264-2272. MH, Kim SU, Nam D. Human neural stem SK. Targeting rat brainstem glioma using human cells target and deliver therapeutic genes to neural stem cells and human mesenchymal stem Schmidt NO, Koeder D, Messing M, Mueller FJ, breast cancer brain metastasis. Mol Ther, 2009 cells. Clin Cancer Res. 2009 Aug 1;15(15):4925- Aboody KS, Kim, SU, Black PM, Carroll RS, Jan 6 [Epub ahead of print]. 4934. Epub 2009 Jul 28. Westphal M, Lamszus K. Vascular endothelial growth factor-stimulated cerebral microvascular Narantuya D, Nagai A, Sheikh AM, Wakabayashi Hwang DH, Lee HJ, Park IH, Seok JI, Kim BG, endothelial cells mediate the recruitment of K, Shiota Y, Watanabe T, Masuda J, Kobayashi S, Joo IS, Kim, SU. Intrathecal transplantation of neural stem cells to the neurovascular niche. Kim, SU, Yamaguchi S. Microglia transplantation human neural stem cells overexpressing VEGF Brain Res. 2009 May 1;1268:24-37. Epub 2009 attenuates white matter injury in rat chronic provide behavioral improvement, disease onset Mar 10. ischemia model via matrix metalloproteinase-2 delay and survival extension in transgenic ALS inhibition. Brain Res. 2009 Dec 23. [Epub ahead mice. Gene Ther. 2009 Oct; 16(10):1234-1244. Sims TL Jr, Hamner JB, Bush RA, Fischer PE, Kim, of print]. SU, Aboody KS, McCarville B, Danks MK, Park MH, Lee YK, Lee YH, Kim YB, Yun YW, Nam Davidoff AM. Neural progenitor cell- Gutova M, Najbauer J, Chen MY, Kim, SU, SY, Hwang SJ, Han SB, Kim, SU, Hong JT. mediated delivery of osteoprotegerin limits Aboody KS. Therapeutic Targeting of Melanoma Chemokines released from astrocytes promote disease progression in a preclinical model of Cells Using Neural Stem Cells Expressing chemokine receptor 5-mediated neuronal cell neuroblastoma bone metastasis. J Pediatr Surg. Carboxylesterase, a CPT-11 Activating Enzyme. differentiation. Exp Cell Res. 2009 Oct 2009 Jan;44(1):204-210; discussion 210-211. Curr Stem Cell Res Ther. 2009 Dec 2. [Epub 1;315(16):2715-2726. ahead of print].

27 | Annual Report 2009 Publication List

Lee SH, Chung YN, Kim YH, Kim YJ, Park JP, Kwon Palmer SJ, Ng B, Abugharbieh R, Eigenraam L, Raymond, Dr. Lynn A. DK, Kwon OS, Heo JH, Kim YH, Ryu S, and McKeown MJ. Motor reserve and novel Kang HJ, Paek SH, Wang KC, Kim, SU, area recruitment: amplitude and spatial Graham, R.K., Pouladi, M. A., Joshi, P., Lu, G., Yoon BW. Effects of human neural stem characteristics of compensation in Parkinson’s Deng, Y., Wu, N-P., Figueroa, B.E., Metzler, M., cell transplantation in canine spinal cord disease. European Journal of Neuroscience, Andre, V.M., Slow, E.J., Raymond, L., Friedlander, hemisection. Neurol Res. 2009 Nov;31(9):996- 2009, 29: 2187-2196. R., Levine, M.S., Leavitt, B.R., Hayden, M.R. 1002. (2009) Differential susceptibility to excitotoxic Mezei, Dr. Michelle M. stress in YAC128 mouse models of HD between Obayashi S, Tabunoki H, Kim, SU, Satoh J. Gene initiation and progression of disease. Journal of expression profiling of human neural progenitor Briscoe, N and Mezei, MM. Polyglandular Neuroscience, 29(7):2193-2204. cells following the serum-induced astrocyte Autoimmune Syndrome Type 3 in a patient with differentiation. Cell Mol Neurobiol. 2009 Ocular Myasthenia Gravis. Muscle and Nerve Fan, J., Cowan, C.M., Zhang, L., Hayden, M.R., May;29(3):423-438. 2009.40:6;1064-5. Raymond, L.A. (2009) Interaction of postsynaptic density protein-95 with N-methyl-D-aspartate Joo KM, Park IH, Shin JY, Jin J, Kang BG, Kim MH, Pfeffer G, Côté HC, Montaner JS, Li CC, receptors influences excitotoxicity in the YAC Lee SJ, Jo MY, Kim, SU, Nam DH. Human Jitratkosol M, Mezei, MM. Ophthalmoplegia mouse model of Huntington’s disease. Journal neural stem cells can target and deliver and ptosis: mitochondrial toxicity in patients of Neuroscience, 29(35):10928-10938. therapeutic genes to breast cancer brain receiving HIV therapy. Neurology. 2009 Jul metastases. Mol Ther. 2009 Mar;17(3):570-575. 7;73(1):71-2. No abstract available. Rieckmann, Dr. Peter E.

Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim, Oger, Dr. Joel Tremlett H, Yousefi M, Devonshire V, Rieckmann, SU, Masuda J. Lysophosphatidylcholine induces P, Zhao Y and the UBC Neurologists. The impact glial cell activation: role of rho kinase. Glia. 2009 Vavasour IM, Laule C, Li DK, Oger J, Moore GR, of multiple sclerosis relapses on progression Jun;57(8):898-907. Traboulsee A, MacKay AL Longitudinal changes diminishes with time. Neurology 2009; 73:1616- in myelin water fraction in two MS patients with 1623. Leavitt, Dr. Blair R. active disease. J Neurol Sci. 2009 Jan 15;276(1-2):49-53. Koch M, Kingwell E, Rieckmann, P, and Tremlett Graham, R.K., Pouladi, M. A., Joshi, P., Lu, G., H and the UBC Neurologists. The natural history Deng, Y., Wu, N-P., Figueroa, B.E., Metzler, M., Bar-Or A, Oger J, Gibbs E, Niino M, Aziz T, of primary progressive MS. Neurology 2009; 73 Andre, V.M., Slow, E.J., Raymond, L., Friedlander, Renoux C, Alatab S, Shi FD, Campagnolo D, 1996-2002. R., Levine, M.S., Leavitt, BR, Hayden, M.R. Jalili F, Rhodes S, Yamashita T, Fan B, Freedman (2009) Differential susceptibility to excitotoxic MS, Panitch H, Arnold DL, Vollmer T. Serial Ruth, Dr. Thomas J. stress in YAC128 mouse models of HD between combination therapy: is immune modulation in initiation and progression of disease. Journal of multiple sclerosis enhanced by initial immune TJ Ruth. Accelerating production of medical Neuroscience, 29(7):2193-2204. suppression? Multiple Sclerosis 2009 (Aug) isotopes. Nature 457:536-537 (Invited Essay - 29 15(8) 959-964. January 2009). McKeown, Dr. Martin J. Freeman HJ, Gillett HR, Gillett PM, Oger J. Adult V. Sossi, K. Dinelle, R. de la Fuente-Fernandez, AJ Ng B, Abugharbieh R, Hamarneh G, McKeown celiac disease with acetylcholine receptor Stoessl, G.J. Topping, J.E. Holden, M Schulzer, TJ MJ. “Random Walker Based Estimation and antibody positive myasthenia gravis. World J Ruth, D Doudet. Dopamine transporter relation Spatial Analysis of Probabilistic fMRI Activation Gastroenterol. 2009 Oct 14;15(38):4741-4. to levodopa-derived synaptic dopamine in a rat Maps”. MICCAI Workshop on Statistical model of Parkinson’s: an in-vivo imaging study. Modeling and Detection Issues in Intra- and Soliven, E, K Rezania, B Gundogdu,, J Oger, B. J. Neurochemistry. 109:85-92 (2009). Inter-Subject Functional MRI Data Analysis, Arnason, MD Terbutaline in myasthenia: a pilot London-UK, Sep 2009, pp. 37-44 . study. J. neurol Sc. 2009 Feb 15;277(1-2):150-4. DM Semeniuk, JT Cullen, K Gagnon, TJ Ruth, MT Maldonado. Plankton copper requirements and Palmer S J, M. EL, T H, GR M, Troiano A, Pelech, Dr. Steven uptake in the sub-Arctic NE Pacific Ocean. Deep McKeown MJ. Levodopa-sensitive, dynamic Sea Research I. 56, 1130-1142 (2009). changes in effective connectivity during Mukherjee, S., Pelech, S., Neve, R.M., Kuo, W.L., simultaneous movements in Parkinson’s Ziyad, S., Spellman, P.T., Gray, J.W., and Speed, R de la Fuente-Fernández, V Sossi, S McCormick, Disease. Neuroscience. 158(2):693-704. 2009. T.P. Sparse combinatorial inference with an M Schulzer, TJ Ruth, AJ Stoessl. Visualizing application in cancer biology. Bioinformatics. vesicular dopamine dynamics in Parkinson’s Ma Z, Wang JZ, McKeown MJ. Probabilistic 25:265-71 (2009). disease. Synapse 63:713-716 (2009). Boolean Network Analysis of Brain Connectivity in Parkinson’s Disease. IEEE Journal of Selected Pettersen, Dr. Jacqueline A. JA H. Inkster, MJ Adam, T Storr, TJ Ruth. Topics In Signal Processing (special Issue on fMRI Labelling of an Antisense Oligonucleotide with Analysis for Human Brain Mapping). vol. 2, issue Pettersen JA, Black SE, Naqvi S, Jin S, Murray BJ. [18F]FPy5yne. Nucleosides, Nucleotides and 6, pp. 975-985. Nocturnal limb movements are correlated with Nucleic Acids, 28: 1131-1143 (2009). cerebral white matter disease burden. Uthama A, Abugharbieh R, PS J, Traboulsee A, Cerebrovascular Diseases 2009;27(suppl 6):201. Troiano AR, de la Fuente-Fernandez R, Sossi V, McKeown MJ. SPHARM-Based Spatial fMRI Schulzer M, Mak E, Ruth, TJ, Stoessl AJ (2009). Characterization with Intersubject Anatomical Friedman Y, Pettersen JA, Aviv RA, Murray BJ. PET demonstrates reduced dopamine Variability Reduction IEEE Journal of Selected The “eye sign” in acute stroke: Not necessarily transporter expression in PD with dyskinesias. Topics In Signal Processing (special Issue on poor outcome. JNNP 2009 Mar;80(3):291. Neurology. 72: 1211-1216. fMRI Analysis for Human Brain Mapping).2009, vol. 2, issue 6, pp. 907-918. Prout, Dr. Alister Nandhagopal R, Kuramoto L, Schulzer M, Mak E, Cragg J, Lee CS, McKenzie J, McCormick S, Wang ZJ, Lee P and McKeown MJ. A Novel Samii A, Troiano A, Ruth, TJ, Sossi V, de la Segmentation, Mutual Information Network Pfeffer, G., Prout, AJE., Hooge, J., Maguire, J. “Biopsy-proven immune reconstitution Fuente-Fernandez R, Calne DB, Stoessl AJ Frame-work for EEG Analysis of Motor Tasks (2009). Longitudinal progression of sporadic BioMedical Engineering OnLine, 2009. syndrome in a patient with AIDS and cerebral toxoplasmosis” Neurology, (2009);73(4):321. Parkinson’s disease: a multi-tracer positron emission tomography study. Brain.132: 2970-9. Publication List Annual Report 2009 | 28

Sadovnick, Dr. Adele D. Sadovnick, AD. Charcot Lecture: The natural Spacey, Dr. Sian history of multiple sclerosis and gender. J Banwell B, Kennedy J, Sadovnick, AD, Arnold DL, Neurol Sci, 2009, 286:1-5 (doi:10.1016/j. Adams PJ, Garcia E, David LS, Mulatz KJ, Spacey, Magalhaes S, Wambera K, Connolly MB, Yager jns.2009.09.005). SD, Snutch TP.. Ca(V)2.1 P/Q-type calcium J, Mah JK, Shah N, Sebire G, Meaney B, Dilenge channel alternative splicing affects the M-E, Lortie A, Whiting S, Doja A, Levin S, Ramagopalan SV, Dyment DA, Guimond C, Yee functional impact of familial hemiplegic MacDonald EA, Meek D, Wood E, Lowry N, IML, Ebers GC, Sadovnick, AD. No Effect of migraine mutations: implications for calcium Buckley D, Yim C, Awuku M, Guimond C, Cooper Parental Age and the Risk of Multiple Sclerosis: channelopathies. Channels (Austin). 2009 Mar- P, Grand’Maison F, Baird JB, Bhan V, Bar-Or A. A Population Based Study. Neuroepidemiology, Apr;3(2):110-21. Epub 2009 Mar 23. The incidence of acquired demyelination of the 2009;34:106-109. central nervous system in Canadian children, Stoessl, Dr. A. J. Neurology 2009, 72:232-239. Ramagopalan SV, Jake JK, Orton S-M, Dyment DA, Guimond C3, Yee IM, Ebers GC, Sadovnick, Wider C, Dickson DW, Stoessl AJ, Tsuboi Y, Ramagopalan SV, Valdar W, Dyment DA, DeLuca AD.Sex-Ratio of Multiple Sclerosis and Clinical Chapon F, Gutmann L, Lechevalier B, Calne DB, GC, Yee IM, Giovannoni G, Ebers GC, Phenotype. Eur J of Neurol 2009; Epub Nov Personnet DA, Hulihan M, Kachergus J, Sadovnick, AD for the Canadian Collaborative 24,2009. Rademakers R, Baker MC, Grantier LL, Sujith Study Group. Asssociation of Infectious OK, Calne S, Farrer MJ, Wszolek ZK (2009). Mononucleosis with multiple sclerosis: A Jagodic M, Colacios C, Nohra R, Dejean Pallidonigral TDP-43 pathology in Perry population-based study. Neuroepidemiology, A, BeyeenAD, Khademi M, Casemayou A, syndrome. Parkinsonism & Related Disorders Neuroepidemiology 2009;32:257-262 (DOI: Lamouroux L, Duthoit C, Papapietro O, Sjöholm 15: 281-286. 10.1159/000201564). L, Bernard I, Lagrange D, Dahlman I, Lundmark F, Oturai AB, Soendergaard HB, Kemppinen Hasegawa K, Stoessl AJ, Yokoyama T, Kowa H, Green RC, Roberts JS, Cupples LA, Relkin NR, A, Saarela J, Tienari P, Harbo HF, Spurkland A, Wszolek ZK, Yagashita S (2009). Familial Whitehouse PJ, Brown T, La Russe S, Butson M, Ramagopalan SV, Sadovnick, AD, GC Ebers, Parkinsonism: Study of Original Sagamihara Sadovnick, AD, Quaid KA, Chen C, Cook-Deegan Seddighzadeh M, Klareskog L, Alfredsson L, PARK8 (I2020T) Kindred With Variable R, Farrer LA for the REVEAL Group. A Padyukov L, Hillert J, Clanet M, Edan G, Fontaine Clinicopathologic Outcomes. Parkinsonism & Randomized Trial of APOE Genotype Disclosure B, Fournie GJ, Kockum Saoudi I, Olsson T.A Related Disorders 15: 300-306. for Risk of Alzheimer’s Disease: The REVEAL role for VAV1 in experimental autoimmune Study. N Engl J Medl 2009;361:245-254. encephalomyelitis and multiple sclerosis.Science Troiano AR, de la Fuente-Fernandez R, Sossi Translational Medicine, Dec 9 2009 (online). V, Schulzer M, Mak E, Ruth TJ, Stoessl AJ Chao MJ, Ramagopalan SV, Herrera BM, Lincoln (2009). PET demonstrates reduced dopamine MR, Dyment DA, Sadovnick, AD, Ebers GC. Ramagopalan SV, Dyment DA, Guimond C, Orton transporter expression in PD with dyskinesias. Epigenetics in multiple sclerosis susceptibility: S-M, Yee IM, Ebers GC, Sadovnick, AD. Neurology 72: 1211-1216. difference in transgenerational risk localizes Childhood Cow’s Milk Allergy and the Risk of to major histocompatibility complex. Hum Mol Multiple Sclerosis: A Population Based Study. J Olanow CW, Gracies JM, Goetz CG, Stoessl AJ, Genet. 2009; 18:261-266. Neurol Sci 2009;doi:10.1016/j.jns.2009.10.021. Freeman T, Kordower JH, Godbold J, Obeso JA (2009). Clinical pattern and risk factors for Ramagopalan SV, McMahon R, Dyment DA, Ramagopalan SV, Dyment DA, Ebers GC, dyskinesias following fetal nigral transplantation Sadovnick, AD, Ebers GC, Wittkowski KM. An Sadovnick, AD. Gestational Diabetes and in Parkinson’s disease: a double blind video- extended statistical approach provides insights Multiple Sclerosis. Epidemiology 2009; 20:.783- based analysis. Movement Disorders 24: 336- into genetic risk factors for multiple sclerosis 784. 343. in the HLA-DRB1 Gene. BMC Medical Genetics 2009 Feb 4:10:10. Lincoln MR, Ramagopalan SV, Chao MJ, Herrera Farrer MJ, Hulihan MM, Kachergus JM, Dachsel BM, DeLuca GC, Orton SM, Dyment DA, J, Stoessl AJ, Grantier LL, Calne S, Calne DB, Ramagopalan SV, Maugeri NJ, Handunnetthi L, Sadovnick, AD, Ebers GC. Epistasis among HLA- Lechevalier B, Chapon F, Tsuboi Y, Yamada T, Lincoln MR, Orton SM, Dyment DA, Deluca GC, DRB1, HLA-DQA1 and HLA-DQB1 determines Gutmann L, Elibol E, Bhatia KP, Wider CW, Herrera BM, Chao MJ, Sadovnick, AD, Ebers GC, multiple sclerosis susceptibility. PNAS Vilarino-Guell C, Ross OA, Brown LA, Catanedes- Knight JC. Expression of the multiple 2009;106:7542-7547. Casey M, Dickson DW, Wszolek ZK (2009). sclerosis-associated MHC class II Allele HLA- DCTN1 mutations in Perry syndrome. Nature DRB1*1501 is regulated by vitamin D. PLoS Ramagopalan SV, Yee IM, Dyment DA, Orton Genetics 41: 163-165. Genet. 2009 Feb;5(2):e1000369. Epub 2009 Feb SM,Marrie RA, Sadovnick, AD, Ebers GC for the 6. Canadian Collaborative Study Group. Parent-of- Stoessl AJ (2009). Radionuclide scanning to origin effects in multiple sclerosis:observations diagnose Parkinson disease: is it cost effective? Sadovnick, AD, Yee IML, Reis J, . Dyment DA, from interracial matings. Neurol 2009;73:602- Nature Clinical Practice Neurology 5: 10-11. Ebers GC. Age of Onset in Concordant Twins and 605. Other Relative Pairs with MS. Am J Epidemiol Sossi V, Dinelle K, Topping GJ, Holden JE, Doudet 2009;170:289-296. D’Netto MJ, Ward H, Morrison K, Ramagopalan D, Schulzer M, Ruth TJ, Stoessl AJ, de la SV, Dyment DA, DeLuca GC, Handunnetthi L, Fuente-Fernandez R (2009). Dopamine Ramagopalan SV, Byrnes JK, Dyment DA, Sadovnick, AD, Ebers GC. Risk alleles for transporter relation to levodopa-derived Guimond C, Handunnetthi L, Disanto G, Yee multiple scleriosis in multiplex families. Neurol synaptic dopamine in a rat model of Parkinson’s: IM, Ebers GC, Sadovnick, AD. Parent-of-origin 2009; 212:142-144. an in-vivo imaging study. J. Neurochem. 109: of HLA-DRB1*1501 and the Age of Onset of 85-92. Multiple Sclerosis. J Hum Genet 2009;54:547- Ramagopalan SV, Morrison KM, Para A, Handel 549. A, Disanto G, Handunnetthi L, Orton SM, de la Fuente-Fernandez R, Sossi V, McCormick S, Sadovnick, AD, Ebers GC. Variants in ST8SIA1 do Schulzer M, Ruth TJ, Stoessl AJ (2009). Ramagopalan S,Link J,Byrnes J, Dyment D, not play a major role in susceptibility to multiple Visualizing vesicular dopamine dynamics in Giovannoni G, Hintzen R,Sundqvist E, Kockum, sclerosis. J Neuroimmunology 2009; 212:142- Parkinson’s disease. Synapse 63: 713-716. Smestad C, Lie B, Harbo H, Padyukov L, 144. Alfredsson L, Olsson T, Sadovnick, AD, Hillert Nandhagopal R, Kuramoto L, Schulzer M, Mak E, J, Ebers G HLA-DRB1 and Month-of-Birth in Ramagopalan SV, Dyment DA, Guimond C, Yee Cragg J, Lee CS, McKenzie J, McCormick S, Multiple Sclerosis. Neurology 2009;73:2107- IM, Ebers GC, Sadovnick, AD. Mother-child Samii A, Troiano A, Ruth TJ, Sossi V, de la Fuente- 2111. blood group incompatibilities. J Neurol (Epub Oct 1 2009). 29 | Annual Report 2009 Publication List

Fernandez R, Calne DB, Stoessl AJ (2009). Taghibiglou C, C Bradley, T Gaertner, Y Li, Y Krassioukov, A.V., Eng, JJ., Warburton, DE, Longitudinal progression of sporadic Parkinson’s Wang, and YT Wang, Mechanisms involved in Teasell, R; Spinal Cord Injury Rehabilitation disease: a multi-tracer positron emission cholesterol-induced neuronal insulin resistance, Evidence Research Team. A systematic review tomography study. Brain 132: 2970-2979. Neuropharmacology. 57(3): 268-76, 2009. of the management of orthostatic hypotension after spinal cord injury. Arch Phys Med Rehabil. Stoessl AJ (2009). Functional imaging studies Taghibiglou C, HGS Martin, TW Lai, T Cho, S 2009 May;90(5):876-85. Review. of non-motoric manifestations of Parkinson’s Prasad, L Kojic, J Lu, Y Liu, E Lo, S Zhang, JZZ Wu, disease. Parkinsonism Relat Disord 15 (Suppl. 3): YP Li, YH Wen, JH Imm, MS Cynader and YT Townson, Dr. Andrea F. S13-16. Wang. Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic Koo D, Townson A, Dvorak M, Fisher C. Spinal Stowe, Dr. Robert M. neuronal injuries, Nature Medicine. 15: 1399- Epidural Abscess: A Five-Year Case-Controlled 1406, 2009. Review of Neurologic. Outcomes Following Iaria G, Fox CJ, Scheel M, Stowe, RM, Barton JJS Rehabilitation. Archives of Physical Medicine (2009). A case of persistent visual hallucinations and Rehabilitation. 2009 March; (90)3:512-16. of faces following LSD abuse: A functional PHYSICAL MEDICINE & magnetic resonance imaging study. Neurocase, AKY Lee, WC Miller, AF Townson , HA Anton and November 18:1-13. REHABILITATION the F2N2 Research Group. Medication use is associated with fatigue in a sample of Traboulsee, Dr. Anthony Krassioukov, Dr. Andrei community-living individuals who have a spinal cord injury: a chart review. Spinal Cord e-pub, Ebers GC, Reder AT, Traboulsee, A, Li D, Langdon Mailis-Gagnon A, Yegneswaran B, Bharatwal B, 17 Nov 2009. D, Goodin DS, Wolf C, Beckmann K, Konieczny A; Krassioukov AV. Effects of intravenous sodium Investigators of the 16-Year Long-Term Follow- amobarbital vs lidocaine on pain and sensory Travlos, Dr. Andrew Up Study. Long-term follow-up of the original abnormalities in patients with spinal cord injury. interferon-beta1b trial in multiple sclerosis: J Spinal Cord Med. 2009;32(1):49-53. McConkey, M., Oxland, T., Schwab, T., Travlos, design and lessons from a 16-year observational A., Goetz, T. Isometric Testings of Pronation study. Clin Ther. 2009 Aug;31(8):1724-36. McGillivray CF, Hitzig SL, Craven BC, Tonack MI, Strength After Paralysis of Pronator Quadratus Krassioukov AV. Evaluating knowledge of with Lidocaine. Journal of Hand Surgery, Nov Vavasour IM, Laule C, Li DK, Oger J, Moore GR, autonomic dysreflexia among individuals with 2009, 34A: 1612-1617. Traboulsee, A, MacKay AL Longitudinal changes spinal cord injury and their families. J Spinal in myelin water fraction in two MS patients with Cord Med. 2009;32(1):54-62. van Rijn, Dr. Theo active disease.. J Neurol Sci. 2009 Jan 15;276(1- 2):49-53. Alexander MS, Biering-Sorensen F, Bodner D, Brackett NL, Cardenas D, Charlifue S, Creasey G, van Rijn, T. A Physiatrist’s View of Response Dietz V, Ditunno J, Donovan W, Elliott SL, Estores Shift. Journal of Clinical Epidemiology 2009; 62: Tremlett, Dr. Helen L. I, Graves DE, Green B, Gousse A, Jackson AB, 1191-1195. Kennelly M, Karlsson AK, Krassioukov A, Krogh K, Tremlett H, Zhao Y, Devonshire V. Natural Linsenmeyer T, Marino R, Mathias CJ, Perkash history comparisons of primary and secondary I, Sheel AW, Shilero G, Schurch B, Sonksen J, RESPIRATORY progressive multiple sclerosis reveals differences Stiens S, Wecht J, Wuermser LA, Wyndaele JJ. and similarities. Journal of Neurology. 2009 International standards to document remaining Ayas, Dr. Najib T. Mar;256(3):374-81. autonomic function after spinal cord injury. Spinal Cord. 2009 Jan;47(1):36-43. Tremlett H, Yousefi M, Devonshire V, Rieckmann Sadatsafavi M, Marra CA, Ayas NT, Stradling P, Zhao Y and the UBC Neurologists. The impact JR, Fleetham JA. Cost-effectiveness of Oral Inskip, J., Ramer, L., Ramer, M., and Krassioukov, Appliances in treatment of Obstructive Sleep ofmultiple sclerosis relapses on progression A. Autonomic assessment of animals with spinal diminishes with time. Neurology 2009; 73:1616- Apnea-Hypopnea. Sleep and Breathing 2009. cord injury: tools, techniques and translation. 13:241-52. 1623. Accompanying Editorial: Ruth Ann Marrie Spinal Cord. 2009 Jan;47(1):2-35. and Gary Cutter Relapses in multiple sclerosis. AlLawati N, Mulgrew A, Cheema R, VanEeden S, Important or not? Neurology 2009; 73:1612- Calder KB, Estores IM, Krassioukov A. Autonomic 1613. Butt A, Fleetham J, Ayas N. Pro-atherogenic dysreflexia and associated acute neurogenic cytokine profile of patients with suspected pulmonary edema in a patient with spinal cord Koch M, Kingwell E, Rieckmann P and Tremlett obstructive sleep apnea. Sleep and Breathing injury: a case report and review of the literature. 2009. 13: 391-5. H and the UBC Neurologists. The natural history Spinal Cord. Spinal Cord. 2009 Jan 13. [Epub of primary progressive MS. Neurology 2009; 73 ahead of print]. 1996-2002. Wenner J, Norena M, Khan N, Palepu A, Ayas N, Wong H, Dodek P. Reliability of ICU Admitting Harkema SJ, Ferreira CK, van den Brand RJ, and Comorbid Diagnoses, APACHE II score, and Wang, Dr. Yu Tian Krassioukov AV. Improvements in Orthostatic Race in an Electronic ICU Database. Journal of Instability with Stand Locomotor Training Critical Care 2009. 24: 401-7. Ryu JK, T Cho, HB Choi, YT Wang, JB McLarnon. in Individuals with Spinal Cord Injury. J Microglial VEGF Receptor response is an integral Neurotrauma. 2009 Jan 2. [Epub ahead of print]. Mountain S, Hameed M, Dodek P, Ayas N, chemotactic component in alzheimer’s disease Norena M, Chittock D, Wong H. Effect of ICU pathology. J. Neurosci. 29(1): 3-13, 2009. Teasell RW, Hsieh JT, Aubut JA, Eng JJ, Workload as Reflected by ICU Activity on Krassioukov A, Tu L; Spinal Cord Injury Mortality and Time to discharge Alive from ICU. Taghibiglou C, HGS Martin, JK Rose, N Ivanoca, Rehabilitation Evidence Review Research Healthcare Quarterly 2009; 12: 8-14. CHC Lin, HL Lee, S Rai, YT Wang*, and CH Team. Venous thromboembolism after spinal Rankin* (*equal corresponding authors). cord injury. Arch Phys Med Rehabil. 2009 Essential role of SBP-1 activation in oxygen Feb;90(2):232-45. deprivation induced lipid accumulation and increase in body width/length ratio in Ashe, M., J.J. Eng, A. Krassioukov. Physiatrists’ Caenorhabditis elegans. FEBS Letters, 583: 831- opinions and practice patterns for bone health 834, 2009. after SCI. Spinal Cord, 2009 Mar;47(3):242-8.

Publication List Annual Report 2009 | 30

Bai, Dr. Tony R. Daley D, Lemire M, Alkhabir L, Chan-Yeung M, Elwood, Dr. Richard K. He JQ, McDonald T, Sandford A, Stefanowicz D, Hackett TL, Warner SM, Stefanowicz D, Shaheen Tripp B, Zamar D,Bosse Y, Ferretti V, Montpetit Yamada S, Tang M, Richardson K, Halaschek- F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Tessier M-C, Becker A, Kozyrskyj AL, Beilby J, Weiner J, Chan M, Cook, VJ, FitzGerald JM, A, Stick SM, Bai TR, Knight DA. Induction of McCaskie PA, Musk B, Warrington N , James A, Elwood, RK, Brooks-Wilson A, Marra F. Genetic epithelial-mesenchymal transition in primary Laprise A, Palmer LJ , Paré PD, Hudson TJ. variations of NAT2 and CYP2E1 and isoniazid airway epithelial cells from patients with asthma Analyses of associations with asthma in four hepatotoxicity in a diverse population. by transforming growth factor-beta1. Am J asthma population samples from Canada and Pharmacogenomics (2009) 10(0), 1433-1445. Respir Crit Care Med. 180(2):122-133. 2009. Australia. Hum Genet. 2009;125(4): 445-59. Hernández-Garduño E., Rodrigues M., James AL, Bai TR, Mauad T, Abramson MJ, He J-Q, Hallstrand T, Knight D, Chan-Yeung M, Elwood RK. The incidence of pulmonary non- Dolhnikoff M, McKay KO, Maxwell PS, Elliot JG, Sandford A, Tripp B, Zamar D, Bossé Y, Kozyrskyj tuberculous mycobacteria in British Columbia, Green FH. Airway smooth muscle thickness in AL, James A, Laprise C, Daley D. A Thymic Canada. Int J Tuberc Lung Dis. September 2009; asthma is related to severity but not duration of Stromal Lymphopoietin Gene Variant 13:1086-1093. asthma. Eur Respir J.34(5):1040-1045. 2009. Is Associated with Asthma and Airway Hyperresponsiveness. J Allergy Clin Immunol FitzGerald, Dr. J. Mark Carlsten, Dr. Christopher 2009;124(2):222-229. Bahadori, K Doyle-Waters, M Marra,C Lynd, L Tarlo SM, Malo JL. Collaborators (94). Anto J, Zamar D, Tripp B, Ellis G, and Daley D. Path: a tool to facilitate pathway-based Alasaly,K Swiston,J FitzGerald, JM. Economic Bacon S, Beach J, Becklake M, Bernstein D, burden of asthma: a systematic review. BMC Bernstein IL, Boulet LP, Blanc P, Brooks S, Burge genetic association analysis. Bioinformatics 2009;10(1):62. Pulm Med. 2009; 9: 24. Published online 2009 S, Cartier A, Cruz M, Cullinan P, Desrosiers M, May 19. doi: 10.1186/1471-466-9-24. Heederick D, Gautrin D, Hamid Q, Henneberger Zhang J, Daley D, Akhabir L, Stefanowicz D, P, Holness L, Jaakkola M, Jeebhay M, Jones M, Sadatsafavi M, Shahidi N, Marra F, Fitzgerald MJ, Kauffmann F, Kennedy S, Labrecque M, Laraqui Chan-Yeung M, Becker AB, Laprise C, Paré PD, Sandford AJ. Links lack of association of TIM3 Elwood KR, Guo N, Marra CA.A statistical CE, Latza U, Lavoie K, Lemière C, Liss GM, method was used for the meta-analysis of tests Lummus Z, Maestrelli P, Maghni K, Mapp Polymorphisms and allergic phenotypes. BMC Med Genet. 2009;10(1):62. for latent TB in the absence of a gold standard, C, Martin J, Merget R, Moscato G, Muñoz combining random-effect and latent-class X, Newman Taylor A, Nordman H, Pacheco Bosse Y, Lemire M, Poon AH, Daley D, He JQ, methods to estimate test accuracy. J Clin K, Park HS, Quirce S, Redlich C, Ribeiro M, Epidemiol. 2009 Aug 17. Sadeghniiat K, Sastre J, Sigsgaard T, Silverman Sandford A, et al. Asthma and genes encoding F, Siracusa A, Swanson M, Toren K, Vandenplas components of the vitamin D pathway. Respir Res 2009; 10:98. Janda S, Park K, FitzGerald JM, Etminan M, O, Wisnewski A, Arrandale VH, Beniuk S, Swiston J. Statins in COPD: A Systematic Review. Betschel SD, Bonlokke J, Carlsten C, Castellanos Chest 2009;136:734-743. L, Chiry S, Cloutier Y, Cloutier V, DeGuire L, Duronio, Dr. Vincent Dion C, Dudley J, Farah M, Favreau H, Favret S, Tan WC, Lo C, Jong A, Xing L, Wang E, FitzGerald Gaudet D, Gaulin C, Goyer N, Hellyer D, Jolly A, Hundal et al. Oxidized Low Density Lipoprotein MJ, Vollmer W, Buist S, Sin D. Mariijuana and Joseph M, Lafontaine V, Laoué T, Maludzinski Inhibits Macrophage Apoptosis by Blocking chronic obstructive lung disease: a population J, Neis B, Noël A, Phenix P, Roberto C, Simone Ceramide Generation, Thereby Maintaining based study. CMAJ 2009; 180 :814-20. P, St-Jacques B, Straszek S, Sturm P, Suarthana PKB Activation and Bcl-XL Levels. J Biol Chem. E, Truncale T, Turcot J, Villeneuve H, Wade 278:24399-24408 (2003). Bahadori K, FitzGerald JM, Levy RD, Fera T, W, Welman M, Wouters IM, Wozniak G. Links Swiston J. Risk factors and outcomes associated An official ATS proceedings: asthma in the Chen JH, Riazy M, Smith EM, Proud CG, with chronic obstructive pulmonary disease workplace: the Third Jack Pepys Workshop Steinbrecher UP, Duronio, V. Oxidized LDL- exacerbations requiring hospitalization Can Resp on Asthma in the Workplace: answered and mediated macrophage survival involves J 2009; 16: e43-e49. unanswered questions. Proc Am Thorac Soc. elongation factor 2-kinase. Art. Thromb. Vasc. 2009 Aug 1;6(4):339-49. Biol. 29(1): 92-98 (2009). Etminan M, Sadatsafavi M, Jafari S, Doyle- Waters M, Aminzadeh K, Fitzgerald JM. Allen J, Trenga CA, Peretz A, Sullivan JH, Schaeffer DF, Riazy M, Parkar KS, Chen JH, Acetaminophen Use and the Risk of Asthma in Carlsten C, Kaufman JD. Effect of Diesel Exhaust Duronio V, Sawamura T, Steinbrecher UP. LOX-1 Children and Adults: A Systematic Review and Inhalation on Antitoxidant and Oxidative Stress augments oxLDL uptake by lysoPC-stimulated Meta-analysis. Chest. 2009. Responses in Adults with Metabolic Syndrome. murine macrophages but is not required for Inhalation Toxicology. 2009; 21(13):1061. oxLDL clearance from plasma. J Lipid Res, 50: FitzGerald JM, Foucart S, Coyle S, Sampalis J, 1676-1684 (2009). Haine D, Psaradellis E, McIvor RA. Montelukast Ferguson A, Dimich-Ward H, Becker A, Watson as add-on therapy to inhaled corticosteroids in W, DyBuncio A, Carlsten C, Chan-Yeung M. Astanehe A, Finkbeiner MR, Hojabrpour P, To K, the management of asthma (the SAS trial).Can Elevated cord blood IgE is associated with Fotovati A, Shadeo A, Stratford AL, Lam WL, Respir J. 2009 16 Suppl A: 5A-14A. recurrent wheeze and atopy at 7 years in a high Berquin IM, Duronvio V, Dunn SE. The risk cohort. Pediatric Allergy Immunology 2009; transcriptional induction of PIK3CA in tumor Johnston, JC Shahidi NC, Sadatsafavi, M 20:710-713. cells is dependent on the oncoprotein Y-box FitzGerald JM. Treatment Outcomes of binding protein-1. Oncogene 28: 2406-18 Multidrug-Resistant Tuberculosis: A Systematic Daley, Dr. Denise (2009). Review and Meta-Analysis. PLoS 2009.

Subbarao P, Becker A, Brook JR, Daley D, Chen JH, Riazy M, Wang SW, Dai JM, Duronio V, Etminan M, levesque L, Fitzgerlad JM, Brophy Mandhane PJ, Miller G, Turvey S, and Sears Steinbrecher UP. Sphingosine kinase regulates JM. Risk of upper gastro intestinal bleeding MR on behalf of the CHILD study investigators oxidized low density lipoprotein mediated with oral biphosphonates and non steroidal : Epidemiology of asthma: Risk factors for calcium oscilliations and macrophage survival. J anti inflammatory drugs: a case control study. development. Expert Review of Clinical Lipid Res, 2009, Nov. 5 (epub ahead of print). Alimnet Pharmacol Ther 2009;29: 1188-92. Immunology 2009;5(1).

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Yamada S, Richardson K, Halaschek-Wiener J, Lane P, Lam S, McWilliams A, Leriche J, Zhu G, ICGN investigators (includes Levy RD), Chan M, Cook VJ, Fitzgerald JM, Elwood RK, Anderson M, Macaulay C. Confocal fluorescence Gulsvik A, Bakke P, Ghatta S, Anderson W, Lomas Brooks-Wilson A, Marra F. genetic variation of microendoscopy of bronchial epithelium. J DA, Silverman EK, Pillai SG. Association of TRPV4 NAT2 and CYP2E1 and isoniazid hepatotoxicty in Biomed Opt. 2009 Mar-Apr;14(2):024008. Gene Polymorphisms with Chronic Obstructive a diverse population. Pharmacogenomics 2009; Pulmonary Disease. Hum Mol Genet 2009; 18: 10: 1433-1445. Massion P, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, 2053 - 2062. Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, Fleetham, Dr. John A. Miller YE, Franklin WA, Varella-Garcia M Bahadori K, FitzGerald JM, Levy RD, Fera T, Recurrent genomic gains in preinvasive lesions Swiston J. Risk factors and outcomes associated Comondore VR, Cheema R, Fox J, Butt A, as a biomarker of risk for lung cancer. PLoS One. with chronic obstructive pulmonary disease Mancini JGB, Fleetham JA, Ryan CF, Chan S, 2009 Jun 9;4(6):e5611. exacerbations requiring hospitalization. Can Ayas NT. The impact of CPAP on cardiovascular Resp J 2009;16: e43-e49. biomarkers in minimally symptomatic patients Lee P, van den Berg R, Lam S, et al. Color with obstructive sleep apnea: A pilot feasibility fluorescence ratio for detection of bronchial Man, Dr. S. F. Paul randomized crossover trial. Lung. 2009 Jan- dysplasia and carcinoma in situ. Clin Cancer Feb;187(1):17-22. Res. 2009 Jul 15;15(14):4700-5. Epub 2009 Jul Man SF, Zhang X, Vessey R, Walker T, Lee K, Park 7. D, Sin DD. The effects of inhaled and oral Chen H, Lowe AA, Bai Y, Hamilton P, Fleetham corticosteroids on serum inflammatory JA, Almeida FR..Evaluation of a portable Coxson H, Mayo J, Lam S, Santyr G, Parraga biomarkers in COPD: an exploratory study. Ther recording device (ApneaLinktrade mark) for G, Sin D. New and current clinical imaging Adv Respir Dis. 2009; 3: 73-80. case selection of obstructive sleep apnea. Sleep techniques to study chronic obstructive Breath, 13(3):213-9, 2009. pulmonary disease. Am J Respir Crit Care Med. Ngan DA, Vickerman SV, Granville DJ, Man SF, 2009 Oct 1;180(7):588-97. [Epub 2009 July 16]. Sin DD. The possible role of Granzyme B in the Sadatsafavi,M Marra C,Ayas N,Stradling pathogenesis of chronic obstructive pulmonary J,Fleetham J Cost-effectiveness of oral Coxson H, Lam S. Quantitative assessment of disease. Ther Adv Respir Dis. 2009; 3: 113-29. appliances in the treatment of obstructive sleep the airway wall using computed tomography apnea-hypopnea. Sleep Breath 13(3):241-52, and optical coherence tomography. Proc Am Rizkallah J, Man SF, Sin DD. Prevalence of 2009. Thorac Soc. 2009 Aug 15;6(5):439-43. pulmonary embolism in acute exacerbations of COPD: a systematic review and meta-analysis. Al Lawati N, Mulgrew A, Cheema R, VanEeden Yuan R, Hogg J, Pare P, Sin D, Wong J, Nakano Y, Chest. 2009; 135: 786-93. Review. S, Butt A, Fleetham J, Ryan F, Ayas N. Pro- McWilliams A, Lam S, Coxson H. Prediction of atherogenic cytokine profile of patients with the rate of decline in FEV1 in smokers using Tamagawa E, Suda K, Yuan Wei, Xing L, Mui T, suspected obstructive sleep apnea. Sleep & quantitative computed tomography. Thorax. Yuexin Li, van Eeden SF, Man SF, Sin DD. Breathing. 13(4):391-5, 2009. 2009 Nov;64(11):944-9. [Epub 2009 Sep 3]. Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation. Innate Lam, Dr. Stephen C. Soh J, Okumuro N, Lockwood W, Yamamoto H, Immun. 2009; 15: 251-8. Shigematsu H, Zhang W, Chari R, Shames D, Tang Edell E, Lam S, Pass H, et al. Detection and X, MacAulay C, Varella-Garcia M, Vooder T, Yee J, Sadar MD, Sin DD, Kuzyk M, Xing L, Kondra localization of intraepithelial neoplasia and Wistuba II, Lam S, Brekken R, Toyooka S, Minna J, McWilliams A, Man SF, Lam S. Connective invasive carcinoma using fluorescence- J, Lam W, Gazdar A. Oncogene mutations, tissue-activating peptide III: a novel blood reflectance bronchoscopy: an international, copy number gains and mutant allele biomarker for early lung cancer detection. J Clin multicenter clinical trial. J Thorac Oncol. 2009 specific imbalance (MASI) frequently occur Oncol. 2009; 27: 2787-92. Jan;4(1):49-54. together in tumor cells. PLoS One. 2009 Oct 14;4(10):e7464. He JQ, Foreman MG, Shumansky K, Zhang X, Guan J, Lo M, Dockery P, Lam S et al. The x (c) Akhabir L, Sin DD, Man SF, DeMeo DL, Litonjua (-) cystine/glutamate antiporter as a potential Sheel A, Guenette J, Yuan R, Holy L, Mayo J, AA, Silverman EK, Connett JE, Anthonisen NR, therapeutic target for small-cell lung cancer; use McWilliams A, Lam S, Coxson H. Evidence for Wise RA, Pare PD, Sandford AJ. Associations of of sulfasalazine. Cancer Chemother Pharmacol. dysanapsis using computed tomographic IL6 polymorphisms with lung function decline 2009 Aug;64(3):463-72. imaging of the airways in older ex-smokers. J and COPD. Thorax. 2009; 64: 698-704. Appl Physiol. 2009 Nov;107(5):1622-8. Epub Yee J, Sadar M, Sin D, Kyzyk M, Xing L, 2009 Sep 17. Man SF, Sin DD. Thinning Bone and Inhaled Rattenbury J, McWilliams A, Man SFP, Lam S. Corticosteroid in COPD: What to do until there Connective tissue-activating peptide III: a novel Levy, Dr. Robert D. is definitive proof. Chest. 2009; 136:1448-1449. blood biomarker for early lung cancer detection. Editorial. J Clin Oncol. 2009 Jun 10;27(17):2787-92. Epub Zhu G, Agusti A, Gulsvik A, Bakke P, ICGN 2009 May 4. investigators (includes Levy RD), Coxson H, Mui TS, Man JM, McElhaney JE, Sandford AJ, Lomas DA, Silverman EK, Pillai SG. CTLA4 gene Coxson HO, Birmingham CL, Li Y, Man SF, Sin DD. Mayo J, Clifton J, Powell T, McWilliams A, Lam S polymorphisms are associated with chronic Telomere Length and Chronic Obstructive et al. Lung nodules: CT-guided placement of bronchitis. Eur Resp J 2009; 34: 598 - 604. Pulmonary Disease: Evidence of Accelerated microcoils to direct video-assisted thoracoscopic Aging. J Am Geriatr Soc. 2009: 57: 2372-2373. surgical resection. Radiology. 2009 Camp PG, Coxson HO, Levy RD, Pillai S, Anderson Review. Feb;250(2):576-85. W, Vestbo J, Kennedy S, Silverman EK, Lomas DA, Paré PD. Sex differences in emphysema McWilliams, Dr. Annette M. Han W, Gills J, Memmott R, Lam S, Dennis P. The and airway disease in smokers. Chest 2009 chemopreventive agent myoinositol inhibits 136:1480-1488. Yee J, Sadar M, Sin D, Kuzyk M, Xing L, Kondra J, Akt and extracellular signal-regulated kinase in McWilliams A, Man S, Lam S. Connective bronchial lesions from heavy smokers. Cancer Levy AR, Sobolev BG, James D, Barrable W, tissue-activating peptide III: a novel blood Prev Res (Phila Pa). 2009 Apr;2(4):370-6. Epub Clarke-Richardson P, Sullivan SD, Keown P, biomarker for early lung cancer detection. J Clin 2009 Mar 31. Chung S, Straatman L, Levy RD. The costs of Oncol. 2009 Jun 10;27(17):2787-92. Epub 2009 change: direct medical costs of solid organ May 4. transplantation in British Columbia, Canada, 1995-2003. Value in Health. 2009; 12: 282-292.

Publication List Annual Report 2009 | 32

Lee P, vanden Berg R, Lam S, Gazdar A, Grunberg two major susceptibility loci. PLoS Genet. 2009 Behzad AR, Walker DC, Abraham T, McDonough K, McWilliams A, Leriche J, Postmus P, Sutedja Mar;5(3):e1000421. J, Mahmudi-Azer S, Chu F, Shaheen F, Hogg JC, T. Color fluorescence ratio for detection of Paré PD. Localization of DNA and RNA in bronchial dysplasia and carcinoma in situ. Clin Deng L, Bosse Y, Brown N, Chin LY, Sarah C Eosinophil Secretory Granules. Int Arch Allergy Cancer Res. 2009 Jul 15;15(14):4700-5. Epub Connolly, Fairbank NJ, King GG, Maksym GN, Immunol. 2009;152(1):12-27. 2009 Jul 7. Paré PD, Seow CY, Stephen NL. Stress and strain in the contractile and cytoskeletal filaments of Road, Dr. Jeremy Sheel A, Guenette J, Yuan R, Holy L, Mayo J, airway smooth muscle. Pulm Pharmacol Ther. McWilliams A, Lam S, Coxson H. Evidence for 2009;22(5):407-416. Onders R, Elmo M, Khansarinia S, Bowman dysanapsis using computed tomographic B, Yee J, Road J et al. Complete worldwide imaging of the airways in older ex-smokers. J Bosse Y, Chin LY, Paré PD, Seow CY. Chronic operative experience in laparoscopic diaphragm Appl Physiol. 2009 Nov;107(5):1622-8. Epub Activation in Shortened Airway Smooth Muscle: pacing: results and differences in spinal cord 2009 Sep 17. A Synergistic Combination Underlying Airway injured patients and amyotrophic lateral Hyperresponsiveness? Am J Respir Cell Mol sclerosis patients. Surg Endosc 23(7): 1433-43, Mayo J, Clifton J, Powell T, et al. Lung nodules: Biol. 2009 42: 341-348. First published online as 2009. CT-guided placement of microcoils to direct doi:10.1165/rcmb.2008-0448OC. video-assisted thorascopic surgical resection. Miller C, McMullin B, Ghaffari A, Stenzler A, Pick Radiology. 2009 Feb;250(2):576-85. Kasuga I, Hogg JC, Paré PD, Hayashi S, Sedgwick N, Roscoe D, Ghahary A, Road J, Av-Gay Y. EG, Ruan J, Wallace AM, He JQ, Zhang X, Gaseous nitric oxide bactericidal activity Edell E, Lam S, Pass H, et al. Detection and Sandford AJ. Role of genetic susceptibility to retained during intermittent high dose short localization of intraepithelial neoplasia and latent adenoviral infection and decreased lung duration exposure. Nitric Oxide 20:16-23, 2009. invasive carcinoma using fluorescence - function. Respir Med. 2009;103(11):1672-1680. reflectance bronchoscopy: an international, multi-centre clinical trial. J Thorac Oncol. 2009 Zhang J, Daley D, Akhabir L, Stefanowicz D, Ryan, Dr. Francis (Frank) C. Jan;4(1):49-54. Chan-Yeung M, Becker AB, Laprise C, Paré PD, Sandford AJ. Links lack of association of TIM3 Comondore VR, Cheema R, Fox J Butt A, Mancini Lane P, Lam S, McWilliams A, LeRiche Polymorphisms and allergic phenotypes. BMC JGB, Fleetham JA, Ryan CF, Chan S, Ayas NT. J, Anderson M, MacAulay C. Confocal Med Genet. 2009;10(1):62. The impact of CPAP on cardiovascular fluorescence microendoscopy of bronchial biomarkers in minimally symptomatic patients epithelium. J Biomed Opt. 2009 Mar- Camp PG, Coxson HO, Levy RD, Pillai S, Anderson with obstructive sleep apnea: a pilot easibility Apr;14(2):024008. W, Vestbo J, Kennedy SM, Silverman EK, randomized crossover trial. Lung 2009;187:17- Lomas DA, Paré PD. Sex Differences in 22. Pare, Dr. Peter D. Emphysema and Airway Disease in Smokers. Chest 2009;136(6):1480-1488. Sandford, Dr. Andrew J. Bosse Y, Chin LY, Paré PD, Seow CY. Adaptation of airway smooth muscle to basal tone: relevance He JQ, Foreman MG, Shumansky K, Zhang X, Daley D, Lemire M, Akhabir L, Chan-Yeung M, He to airway hyperresponsiveness. Am J Respir Cell Akhabir L, Sin DD, Man SF, DeMeo DL, Litonjua J-Q, McDonald T, Sandford A, Stefanowicz D, Mol Biol 2009;40:13-8. AA, Silverman EK, Connett JE, Anthonisen NR, Tripp B, Zamar D, Bossé Y, Ferretti V, Montpetit Wise RA, Paré PD, Sandford AJ. Associations of A, Tessier M-C, Becker A, Kozyrskyj AL, Beilby J, Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, IL6 polymorphisms with lung function decline McCaskie PA, Musk B, Warrington N, James A, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka and COPD. Thorax 2009;64:698-704. Laprise C, Palmer LJ, Paré PD, Hudson TJ. M, Niimi A, Chin K, Paré PD, Mishima M. Body Analyses of associations with asthma in four Mass Index in Male Patients with Chronic Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford asthma population samples from Canada and Obstructive Pulmonary Disease; Correlation A, Paré PD, McKay K, Kayserova H, Piskackova Australia. Hum Genet. 2009;125:445-59. with Low Attenuation Areas on CT. Thorax. 2009 T, Macek M, Czerska K, Sands D, Tiddens H, Jan;64(1):20-5. Margarit S, Repetto G, Sontag MK, Accurso FJ, He J-Q, Foreman MG, Shumansky K, Zhang X, Blackman S, Cutting GR, Tsui LC, Corey M, Durie Akhabir L, Sin DD, Man SFP, DeMeo DL, Litonjua Kozyrskyj AL, HayGlass KT, Sandford A, Paré PD, P, Zielenski J, Strug LJ. Modifier gene study of AA, Silverman EK, Connett JE, Anthonisen NR, Chan-Yeung M, Becker AB. A novel study meconium ileus in cystic fibrosis: statistical Wise RA, Paré PD, Sandford AJ. Associations of design to investigate the early life origins of considerations and gene mapping results. Hum IL6 polymorphisms with lung function decline asthma in children. Allergy. 2009;64(8):1185-93. Genet. 2009 Aug 7. and COPD. Thorax. 2009;64:698-704.

Daley D, Lemire M, Akhabir L, Chan-Yeung M, He Silverman EK, Spira A, Paré PD. Genetics and Kozyrskyj AL, HayGlass KT, Sandford AJ, Paré PD, JQ, McDonald T, Sandford A, Stefanowicz D, genomics of chronic obstructive pulmonary Chan-Yeung M, Becker AB. A novel study Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit disease.Proc Am Thorac Soc. 2009 Sep design to investigate the early life origins of A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, 15;6(6):539-42. asthma in children (SAGE study). Allergy. McCaskie PA, Musk B, Warrington N, James A, 2009;64:1185-1193. Laprise C, Palmer LJ, Paré PD, Hudson TJ. Yuan R, Hogg JC, Paré PD, Sin DD, Wong JC, Analyses of associations with asthma in four Nakano Y, McWilliams AM, Lam S, Coxson HO. He J-Q, Hallstrand TS, Knight D, Chan-Yeung M, asthma population samples from Canada and Prediction of the rate of decline in FEV(1) Sandford A, Tripp B, Zamar D, Bossé Y, Australia. Hum Genet. 2009;125(4):445-59. in smokers using quantitative Computed Kozyrskyj AL, James A, Laprise C, Daley Tomography. Thorax. 2009 Nov;64(11):944-9. D. A thymic stromal lymphopoietin gene Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need variant is associated with asthma and airway AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Chin LY, Bossé Y, Jiao Y, Solomon D, Hackett TL, hyperresponsiveness. J. Allergy Clin. Immunol. Ruppert A, Lødrup Carlsen KC, Roses A, Paré PD, Seow CY. Human airway smooth 2009;124:222-229. Anderson W, Rennard SI, Lomas DA, Silverman muscle is structurally and mechanically similar EK, Goldstein DB; ICGN Investigators: Agusti AG, to that of other species. Eur Respir J. 2009 Nov Kasuga I, Hogg JC, Paré PD, Hayashi S, Sedgwick Calverley PM, Donner CF, Levy RD, Make BJ, Paré 19 [e-Print] doi:10.1183/09031936.00136709 EG, Ruan J, Wallace AM, He J-Q, Zhang X, PD, Vestbo J, Wouters EF. A genome-wide Sandford AJ. Role of genetic susceptibility to association study in chronic obstructive latent adenoviral infection and decreased lung pulmonary disease (COPD): identification of function. Respir. Med. 2009 Jun 5. [Epub ahead of print].

33 | Annual Report 2009 Publication List

Zhang J, Daley D, Akhabir L, Stefanowicz D, Mui TSY*, Man JM*, McElhaney JE, Sandford AJ, Tan WC, Seale P, Ip M, Shim YS, Chiang CH, Chan-Yeung M, Becker AB, Laprise C, Paré PD, Coxson HO, Birmingham CL, Li Y, Man SFP, Ng TP, Abisheganadan J, Charoenratanakul S, Sandford AJ. Lack of association of TIM3 and Sin DD. Telomere length and chronic DeGuia T, Mahayiddin A, Mangunnegoro H, polymorphisms and allergic phenotypes. BMC obstructive pulmonary disease: evidence Xu YJ, Zhong NS. Trends in COPD mortality and Med Genet. 2009:10;62. of accelerated aging. Journal of American hospitalizations in countries and regions of Geriatrics Society 2009;57:2372-74. Asia-Pacific. Respirology: 2009 Jan;14(1):90-7. Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford PubMed PMID: 19144054. A, Paré PD, McKay K, Kayserova H, Piskackova Sin DD, Tashkin D, Zhang X, Radner F, Sjobring U, T, Macek M, Czerska K, Sands D, Tiddens H, Thoren A, Calverley PM, Rennard SI. Budesonide Tan WC, Lo C, Jong A, Xing L, Fitzgerald MJ, Margarit S, Repetto G, Sontag MK, Accurso FJ, and the risk of pneumonia: a meta-analysis of Vollmer WM, Buist SA, Sin DD. Vancouver Blackman S, Cutting GR, Tsui LC, Corey M, Durie individual patient data. Lancet 2009;374:712-9. Burden of Obstructive Lung Disease (BOLD) P, Zielenski J, Strug LJ. Modifier gene study of Research Group. Marijuana and chronic meconium ileus in cystic fibrosis: statistical Coxson HO, Mayo J, Lam S, Santyr G, Parraga G, obstructive lung disease: a population-based considerations and gene mapping results. Hum and Sin DD. New and current clinical imaging study. CMAJ. 2009 Apr 14;180(8):814-20. Genet. 2009 Aug 7. [Epub ahead of print]. techniques to study chronic obstructive PubMed PMID: 19364790; PubMed Central pulmonary disease. American Journal of PMCID: PMC2665947. Sin, Dr. Donald D. Respiratory and Critical Care Medicine 2009;180:588-97. Ng TP, Niti M, Fones C, Yap KB, Tan WC. Co- Rizkallah J, Man SFP, Sin DD. Prevalence of morbid association of depression and COPD: a pulmonary embolism in acute exacerbations Yuan R*, Hogg JC, Pare PD, Sin DD, McWilliams population-based study. Respir Med. 2009 of chronic obstructive pulmonary disease: a AM, Lam S, Coxson HO. Prediction of the rate of Jun;103(6):895-901. Epub 2009 Jan 10. PubMed systematic review and metaanalysis. Chest decline in FEV1 in smokers using quantitative PMID: 19136238. 2009;135:786-93. computed tomography. Thorax 2009;64:944-9. O’Byrne PM, Lamm CJ, Busse WW, Tan WC, Tan WC, Lo C, Jong A, Xing L, FitzGerald MJ, van Gestel YRB, Hoeks SE, Sin DD, Huzeir V, Stam Pedersen S. The Effects of Inhaled Budesonide Vollmer WM, Buist AS, Sin DD. Marijuana and H, Mertens FW, van Domburg RT, Bax JJ, on Lung Function in Smokers and Nonsmokers chronic obstructive lung disease-a population Poldermans D. Chronic obstructive pulmonary With Mild Persistent Asthma. Chest. 2009 Dec, based study. Canadian Medical Association disease and cancer mortality: influence of 136(6):1514-20. [Epub 2009 Aug 26] PubMed Journal 2009;180:814-20. statins. Thorax 2009;64:963-7. PMID: 19710291.

Lee J and Sin DD. Biomarkers in chronic Shakoori TA, Sin DD, Ghafoor F, Bashir S, Bokhari Van Eeden, Dr. Stephanus F. obstructive pulmonary disease. Minerva SZ. Serum surfactant protein D during acute Pneumologica 2009 Marzo; 48:31-44. exacerbations of chronic obstructive pulmonary Sakamoto N, Hayashi S, Mukae H, Vincent R, disease. Disease Markers, 2009: 27(6): 287. Hogg JC, van Eeden SF. Effect of atorvastatin on Yee J, Sadar MD, Sin DD, Kuzyk M, Xing L, Kondra PM10-induced cytokine production by human J, McWilliams A, Man SF, Lam S. Connective Churg A, Sin DD, Everett D, Brown K, Cool C. alveolar macrophages and bronchial epithelial tissue-activating peptide III: a novel blood Pathologic patterns and survival in chronic cells. Int J Toxicol. 28(1):17-23. 2009. biomarker for early lung cancer detection. hypersensitivity pneumonitis. American Journal Journal of Clinical Oncology 2009;27:2787-92. of Surgical Pathology 2009;33:1765-70. Tamagawa E, Suda K, Yuan W, Li X, Mui T, Yuexin L, van Eeden SF, Man SF, Sin DD. Tamagawa E, Suda K, Wei Y, Xing L, Mui T, Li Y, Swiston, Dr. John R. Endotoxin-induced translocation of interleukin-6 van Eeden SF, Man SF, Sin DD. Endotoxin from lungs to the systemic circulation. Innate induced translocation of interleukin-6 from Katayoun Bahadori, J Mark FitzGerald, Robert Immun. 15(4):251-258. 2009. lungs to the systemic circulation. Innate Levy, Tharwat Fera, and John Swiston. Risk Immunity 2009;15:251-8. Factors and outcomes associated with COPD Ling SH, van Eeden SF. Particulate matter air exacerbations requiring hospitalization. pollution exposure: role in the development and He JQ, Foreman M, Shumansky K, Zhang X, Canadian Respiratory Journal 2009;16:e43-49. exacerbation of chronic obstructive pulmonary Akhabir L, Sin DD, Man SFP, DeMeo D, Litonjua disease. Int J Chron Obstruct Pulmon Dis. AA, Silverman E, Connett JE, Anthonisen NR, McGowan C, Swiston J, Notarius C, Mak S, 4(1):233-243. 2009. Wise RA, Pare PD, Sandford AJ. Associations of Morris B, Picton P, Granton J, and Floras J. IL-6 polymorphisms with lung function decline Discordance between microneurographic and Hogg JC, van Eeden SF. Pulmonary and systemic and COPD. Thorax 2009;64:698-704. heart rate spectral indices of sympathetic response to atmospheric pollution. Respirology. activity in pulmonary arterial hypertension. 14(3):336-346. 2009. van Gestel YR, Hoeks S, Sin DD, Stam H, Mertens Heart 2009;95:754-758. FW, van Domburg RT, Poldermans D. Beta Al Lawati N, Mulgrew A, Cheema R, vanEeden S, blockers and quality of life in patients with Katayoun Bahadori, Carlo Marra, Kadria Alasaly, Butt A, Fleetham J, Ryan F, Ayas N. chronic obstructive pulmonary disease and Larry Lynd, Mary MR Doyle-Waters, John Robert Pro-atherogenic cytokine profile of patients peripheral arterial disease. International Journal Swiston, and J Mark FitzGerald. Economic with suspected obstructive sleep apnea. Sleep of COPD 2009;4:177-183. burden of asthma – a systematic review. BMC Breath. 13(4):391-395. 2009. Pulmonary Medicine 2009;9:24. Man SF, Zhang X, Vessey R, Walker T, Lee K, Park Wilcox, Dr. Pearce G. D, and Sin DD. The effects of inhaled and oral Surinder Janda, Kirily Park, J Mark FitzGerald, corticosteroids on serum inflammatory Mahyar Etminan, and John Robert Swiston. Ryerson C, Churg A, Wilcox P. Pleural Effusion: A biomarkers in COPD: an exploratory study. Statins in COPD. Chest 2009;136:734-743. Diagnostic Dilemma. Chest. 136(3): 934-7, 2009. Therapeutic Advances in Respiratory Disease Vandemheen K, O’Connor A, Bell S, Freitag 2009;4:177-183. Tan-Hogg, Dr. Wan C. A, Bye P, Jeanneret A, Bertiaumme Y, Brown N, Wilcox P, Ryan G, Rabin H, Morrisson N, Ngan DA, Vickerman SV, Granville DJ, Man SFP O’Byrne PM, Pedersen S, Lamm CJ, Tan WC, Paterson N, Aaron S. Randomized Trial of and Sin DD. The possible role of granzyme Busse WW; START Investigators Group. Severe a Decision Aid for Cystic Fibrosis Patients B in the pathogenesis of chronic obstructive exacerbations and decline in lung function in considering Lung Transplantation Am J Resp Crit pulmonary disease. Therapeutic Advances in asthma. Am J Respir Crit Care Med. 2009 Jan Care Med. 180: 761-8, 2009. Respiratory Disease 2009;3:113-29. 1;179(1):19-24. PubMed PMID: 18990678.

Publication List Annual Report 2009 | 34

Wilcox P. Interstitial Lung Disease in Systemic RHEUMATOLOGY Esdaile, Dr. John M. Sclerosis Canadian Respiratory Journal. 17: 42, 2009. Chalmers, Dr. Andrew Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong Yeung, Dr. Moira M. Mease PJ, Hobbs K, Chalmers A, El-Gabalawy H, H, Singer J, Kopec J, Guermazi A, Peterfy C, Bookman A, Keystone E, Furst D, Anklesaria P, Nicolaou S, Munk PL, Esdaile JM. Association of Kozyrsky A, Hayglass K, Pare P, Sandford A, Chan- Heald AE. Local delivery of a recombinant biomarkers with pre-radiographically defined Yeung M, Becker AB. A Novel Study Design to adenoassociated vector containing a tumour and radiographically defined knee osteoarthritis investigate the early life origins of asthma in necrosis factor alpha antagonist gene in in a population-based study. Arthritis Rheum children. Allergy 2009; 64:1185-93. inflammatory arthritis: a phase 1 dose 2009;60:1372-80. escalation safety and tolerability study. Ann Beyers N, Chan-Yeung M, Pierard C. A bigger and Rheum Dis 2009;68:1247-1254. Kur, Dr. Jason better International Journal of Tuberculosis and Lung Disease. Int J Tuberc Lung Dis. 2009 Choi, Dr. Hyon K. Kur J and Esdaile JM. Posterior Reversible Jan;13(1):3. Encephalopathy - An Under Recognized Forman JP, Choi H, Curhan GC. Uric acid Manifestation of Systemic Lupus Erythematosus. Malo JL, Chan-Yeung M. Agents causing J Rheum 2006; 33:2178-83. occupational asthma. J Allergy Clin Immunol. and insulin sensitivity and risk of incident 2009; 123: 545-50. hypertension. Arch Intern Med. 2009 Jan 26; 169(2):155-62. PMCID: PMC2712216. Lacaille, Dr. Diane V. Ferguson A, Dimich-Ward H, Becker A Watson Choi HK, Gao X, Curhan G. Vitamin C intake and Simon TA, Smitten AL, Franklin J, Askling J, W, DyBuncio A, Carlsten C, Chan-Yeung M. Short Lacaille D, Wolfe F, Hochberg MC, Qi K, Suissa S. Report: Elevated cord blood IgE is associated the risk of gout in men: A Prospective Study. Arch Intern Med. 2009 Mar 9; 169(5):502-7. Malignancies in the rheumatoid arthritis with recurrent wheeze and atopy at 7 years in abatacept clinical development program: An a high risk cohort. Pediatir Allergy Immunology epidemiological assessment. Ann Rheum Dis 2009; Feb 13; e-pub. Qureshi AA, Choi HK, Setty AR, Curhan GC. Psoriasis and the risk of diabetes and 2009;(68)12:1819-1826. hypertension: a prospective study of US female Mak J CW, Chan-Yeung M, Ho SP, Chan KS, Choo FitzGerald J, Mandl L, Cron R, Lacaille D, Deane K, Yee KS, Chau CH, Cheung AHK, Ip SM nurses. Arch Dermatol. 2009 Apr; 145(4):379- 82. K, Franchin G, Lim S, Park CC. Rheumatology and members of the Hong Kong Thoracic Society fellows’ perception on training and careers COPD study group. Elevated plasma TGF-beta1 in academia: Results from the Rheumatology levels in patients with chronic obstructive Jick SS, Choi H, Li L, McInnes IB, Sattar N. Hyperlipidemia, statin use and the risk of Fellow Research and Academic Training Survey. pulmonary disease. Respir Med. 2009; Arthritis Rheum 2009;61(2):266-73. Jul;103(7):1083-9. developing rheumatoid arthritis. Ann Rheum Dis. 2009 Apr; 68(4):546-51. Li LC, Adam P, Townsend AF, Stacey D, Lacaille D, Chan-Yeung M, Carlsten C.Reasonable Cox S, McGowan J, Tugwell P, Sinclair G, Ho alternatives to spirometry for diagnosing Forman JP, Choi H, Curhan GC. Fructose and vitamin C intake do not influence risk for K, Backman CL. Improving healthcare consumer chronic obstructive pulmonary disease: is the effectiveness: An Animated, Self-serve, Web- peak flow meter the answer? Int J Tuberc Lung developing hypertension. J Am Soc Nephrol. 2009 Apr; 20(4):863-71. PMCID: PMC2663841. based Research Tool (ANSWER) for people Dis. 2009 Mar;13(3):279-80. with early rheumatoid arthritis. BMC Medical Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar- Informatics and Decision Making. 2009, 9:40, Daley D, Lemire M, Akhabir L, Chan-Yeung M, He http://www.biomedcentral.com/content/ JQ, McDonald T, Sandford A, Stefanowicz D, sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. 2009 pdf/1472-6947-9-40.pdf doi:10.1186/1472- Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit 6947-9-40. A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, Jun; 154(6):807-13. McCaskie PA, Musk B, Warrington N, James A, Beaton D, Bombardier C, Escorpizo R, Zhang W, Laprise C, Palmer LJ, Paré PD, Hudson TJ. Luk AJ, Levin GP, Moore EE, Zhou XH, Kestenbaum BR, Choi HK. Allopurinol Lacaille D, Boonen A, Osborne RH, Anis AH, Analyses of associations with asthma in four Strand CV, Tugwell PS. Measuring worker asthma population samples from Canada and and mortality in hyperuricemic patients. Rheumatology (Oxford). 2009 Jul; 48(7):804-6. productivity: frameworks and measures. J Australia. Hum Genet. 2009 May;125(4):445-59. Rheumatol 2009;36;9:2100-9. Daley D, Anita Kozyrskyj , Yohan Boss, Catherine Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Laprise Alan James , Moira Chan-Yeung, Andrew Albert DA. Hyperuricemia and risk of stroke: Shojania, Dr. Kamran Sandford , Ben Tripp , Darryl Knight , David A systematic review and meta-analysis. Arthritis Zamar , Jianqing He , Teal Hallstrand Catherine Rheum. 2009 Jul 15; 61(7):885-92. PMCID: Choi HK. Al-Arfaj AM. Eftekhari A. Munk PL. Laprise A Thymic Stromal Lymphopoietin Gene PMC2714267. Shojania K. Reid G. Nicolaou S. Dual energy Variant Is Associated with Asthma and Airway computed tomography in tophaceous gout. Ann Hyperresponsiveness. J Allergy Clin Immunol; Hak AE, Curhan G, Grodstein FD, Choi HK. Rheum Dis 2009;68(10):1609-12. 2009: 124(2):222-9. Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis. 2009 Jul 9. Hemmati I, Ensworth S, Shojania K. Coarctation Zhang J, Daley D, Akhabir L, Stefanowicz D, [Epub ahead of print]. of the Aorta in an Infant Exposed to Etanercept Chan-Yeung M, Becker A, Laprise C, Pare PD in Utero. J Rheumatol 2009;36(12):2848. and Sandford AJ. Lack of Association of TIM3 Bansback N, Ara R, Ward S, Anis A, Choi HK. Polymorphisms and Allergic Phenotypes. BMC Statin therapy in rheumatoid arthritis: A cost Shojania K, Ratzlaff M. Group visits for Medical Genetics 2009 Jun 30;10(1):62. [Epub effectiveness and value-of-information analysis. rheumatoid arthritis. A pilot study. Clin ahead of print]. Pharmacoeconomics. 2009; 27(1):25-37. Rheumatol. Online first. Vol 29 (1).

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