Abstracts E- Posters World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Page 36 Ophthalmology 2018 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Korobova Lyudmila Sergeevna et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Anesthesia and levels of glucose, lactate, cortisol in plasma in ophthalmic surgery in children Korobova Lyudmila Sergeevna¹, Lazarev V B², Balashova L M² and Kantarzhi E P² ¹Morozov Russian Children's Clinical Hospital, Department of Health of Moskow, Moscow, Russia ²Pirogov Russian National Research Medical University, Moscow, Russia
perations on the eyeball and the auxiliary apparatus of the eye, as Biography well as any intervention in the body, lead to a stress reaction in the O Korobova Lyudmila Sergeevna is a Doctor (Anesthesiologist) of the highest body with a change in the function of all organs and systems in general, qualification category of the Department of anesthesiology and intensive which has been shown in numerous studies. The task of anesthesia is care. She is an applicant for the Degree of candidate of Medical Sciences. to protect the body in response to stress. She has more than five publications and a patent for the method of Anesthesia in Ophthalmic Surgery in children.
Material & Methods: 100 patients aged from 4 to 18 years, who [email protected] were evaluated with glucose, lactate, and cortisol at three stages of operation in 5 groups with different methods of anesthesia, were studied. Patients were randomized by 20 people. Maintenance of anesthesia with spontaneous breathing through the laryngeal mask was carried out in the following groups: inhalation of sevoflurane in an
oxygen-air mixture with an O2 content of 40%, as well as intravenous administration of a propofol solution at a dose of 2 mg/kg immediately after induction and in groups; 1) the anesthetic concentration of 1.0 MAC (mimimum alveolar concentration); regional anesthesia (RA): block van lint and infraorbital anesthesia; 2) the anesthetic concentration to 1.5 MAC; intravenously within 10 minutes after induction of anesthesia paracetamol solution at a dose of 15 mg/kg; 3) anesthetic concentrations of 0.7- 0.9 MAC; RA: van lint block and the wing-palatal anesthesia (palatal access); 4) anesthetic concentration 0.7-0.9 MAC; RA: block van lint, intraorbitally anesthesia and wing- palatal anesthesia; 5) anaesthetic concentrations of 0.7-0.9 MAC; RA: van lint block and retro bulbar anesthesia.
Research result: Despite the fact that in a number of cases at the study stages there were sufficient changes in the estimated values, the values of which were within the WHO reference values, all variants of anesthesia allowed to provide a high degree of anesthetic protection in ophthalmic surgical interventions and can be recommended for routine practical application
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 37 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Bilalov B E et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 The modified antiglaucomatous operation in terminal glaucoma with pain syndrome Bilalov B E, Bakhritdinova F A and Bilalov E N Tashkent medical academy, Uzbekistan
Relevance: Terminal glaucoma is one of the most severe forms of glaucomatous Biography process and is usually accompanied by pain syndrome, which practically does Bilalov B E has graduated from Tashkent Medical Academy in 2012. In not lend itself to drug therapy. 2015 he has completed Ophthalmology Master’s degree. From 2016, he is working as the Head of Department of Ophthalmology in 2nd clinic Purpose: To improve the results of surgical treatment of terminal glaucoma of TMA. Recently, he is working on dissertation for PhD degree, entitled with pain syndrome by preventing excessive scarring by autodrenation of the Optimization of surgery in terminal glaucoma. He was the author of more than 15 publications. His specialization includes glaucoma, filtration zone. neuroophthalmology, pterigium and pathology of eye in general diseases.
Material & Methods: The results of treatment of 30 patients with terminal [email protected] glaucoma with pain syndrome are summarized in the work. The visual functions in patients with terminal glaucoma were almost lost. The average level of ophthalmotonus against the background of the maximum drug therapy was 47.1±5.2 mmHg. Pain syndrome of varying degrees of intensity occurred in all patients with terminal glaucoma. The proposed method was carried out as follows. In the 12-hour zone, a quadrangular scleral flap was formed by cutting off the base to the limbus 4 ˟ 4 mm in size. Then, from the deep layers of the sclera in the drainage zone, a triangular flap was cut out and excised by a base to the limbus with the size of 3 mm and the height of 4 mm. Basal iridectomy was performed. The free angles of the quadrangular flap, cut from the surface layers of the sclera, were fixed by two nodular sutures from silk 8/0 to 1/3 of the vertical boundaries of the scleral bed, thus forming a scleral roller that prevents intimate sclero-scleral adaptation. All patients examined by standard ophthalmologic methods of diagnosis.
Results & Discussion: Intra Ocular Pressure (IOP) decreased in 2.3 concerning postoperative indices and averaged over 20.3±1.8 mmHg. In the long-term period after 1 year in 28 (93.3%) patients the pain syndrome was completely stopped. It is necessary to note the main thing that up to 1 year after the operation, we avoid enucleation of the eye in all 30 patients. In this case, the phenomena of developing of subatrophy of the eye in these terms were not recorded in any patient.
Conclusions: The proposed operation of deep sclerectomy with autodrenation of the filtration zone allowed increasing the effectiveness of terminal glaucoma treatment. Pain relief was noted in 96.6% of cases
Research result: Despite the fact that in a number of cases at the study stages there were sufficient changes in the estimated values, the values of which were within the WHO reference values, all variants of anesthesia allowed to provide a high degree of anesthetic protection in ophthalmic surgical interventions and can be recommended for routine practical application
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 38 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Bilalov E N et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Improvement of treatment of exudative age-related macular degeneration Bilalov E N1, Yusupov A F2, Mukhanov Sh A2 1Tashkent medical academy, Uzbekistan 2Eye Clinic “Sikhat-Kuz”, Uzbekistan
Relevance: Efficiency assessment of combined treatment of exudative Biography age-related macular degeneration with different types of choroidal Bilalov E N is the Head of Ophthalmology Department in Tashkent Medical neovascularization (CNV) including anti-angiogenic drug with transpupillary Academy, the biggest medical HEI in Uzbekistan. He has acquired PhD thermotherapy. degree on the topic Elaboration and Pathogenetic Explanation of New Method of Surgical Treatment of Pterygium in 1998, in 2010 he has Material & Methods: 60 patients: 30 patients (30 eyes) with mixed CNV, acquired DSc degree on the topic Aspects of Pterygium Development and Elaboration of its Treatment Algorithms. He has more than 150 30 patients (30 eyes) with occult CNV were examined. The age of patients publications among which there are not only articles and abstracts, but ranged from 50 to 80 years (23 men and 37 women). 2 groups of patients also methodical guidelines and textbooks for students. For more than were formed depending on the obtained treatment. Antivazoproliferative 14 years he has been Director for Master’s degree program in TMA. He is an expert in Glaucoma, Cataract Surgery as well as Oculoplastic Surgery, therapy with ranibizumab was applied in first group patients. Intravitreal Pterygium, AMD. injection of ranibizumab was prescribed in a dose 0.2 ml (0.2 mg) on the 3+PRN. The second group of patients received combined treatment: one [email protected] session of transpupillary thermotherapy then in 10 days intravitreal injections of ranibizumab for 1+PRN.
Results: In the first group during 12 months of observations more than 3 injections of ranibizumab were needed in 50% of cases (10 eyes) in the patients with mixed CNV. The average number of injections per year was 4.0. In the patients with occult CNV more than 3 injections of ranibizumab needed for 11 eyes (73.3%), the average number of injections per year was 5.0. In the second group with combined therapy repeated injections of ranibizumab was necessary for some patients. During 12 months of observation in patients with mixed CNV 2 injections of ranibizumab were needed in 8 eyes (53.3%), the 3 injections in 5 (33.3%) eyes. The total number of injections per year in these patients was 2.2. Patients with occult CNV: 2 injections in 6 eyes (30%), 3 injections in 5 (25%). The average number of injections per year was 1.8. That is much less than monotherapy with ranibizumab.
Conclusion: A combined method of treatment in patients with exudative age- related macular degeneration provides cost reduction in 2 times, that is economically efficient in ophthalmologic practice.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 39 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Nozimov A E et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Optimized method of surgical treatment of persistently recurrent pterigium Nozimov A E1, Bilalov E N2 and Narzikulova K I2 1Eye Clinic Sikhat-Kuz, Uzbekistan 2Tashkent medical Academy, Uzbekistan
Relevance: The problem of recurrence of the pterygium remains a topical issue of ophthalmic surgery and, according to the data of different authors, ranges from 30 to 70%.
Aim: The purpose of this study was to optimize the method of surgical treatment of persistently recurring pterygium.
Material & Methods: The study group consisted of 15 (15 eyes) patients with persistently recurring pterygium. In all cases, pterygium was operated more than 2 times or more, after which in the area of removed pterygium the formation of persistent opacity, incorrect astigmatism, gross of scaring of the bulbar conjunctiva at great length were not¬ed. All patients underwent standard preoperative examination, and optical coherence tomography was additionally performed to assess the thickness of the cornea in the projection of the pterygium. According to the keratometry, the cylindrical component was from 1.0 to 6.0 dptr. Preoperative visual acuity in the analyzed cases was 0.3-0.7 with correction. The proposed method consists of cutting off and excising the body and head of the pterygium with the surrounding altered tissues within the healthy conjunctiva and along the semilunar fold, cleansing the surface of the cornea. After excision of the pterygium, produces a recession of the internal rectus muscle 3-4 mm posteriorly. From the surface layers of the upper segment of the bulbar conjunctiva, a thin autograft of the semilunar form is cut out on the feeding leg, commensurate with the formed tissue defect on the sclera. The autograft is moved and laid on the formed defect in the inner segment and sew to the healthy part of the conjunctiva by 5-6 knotty sutures. All patients underwent surgical treatment according to this method. After the operation, all patients underwent standard postoperative anti-inflammatory and keratoprotective therapy.
Results & Discussion: During the surgical treatment and in the postoperative period, no complications were detected. According to keratometry, the cylindrical component decreased to 0.8 Diopters. Visual acuity in 10 cases increased to 0.7-0.9 without correction, which is associated with excision of scar-altered tissues and a decrease in the values of corneal astigmatism. The period of observation of patients was 12 months. Relapse of the disease according to remote observations of patients was observed on 1 eye and was amounted 6.6%.
Conclusions: The proposed modified method of treatment based on the recession of the internal rectus muscle with conjunctival autoplasty on the stalk can be used as a method of choice for a persistently relapsing pterygium.
Biography
Nozimov A E has graduated from Tashkent Medical Academy in 2014. In 2017 he has completed his Masters’degree in Ophthalmology. From 2017 he is working as Ophthalmologist in Eye Clinic Sikhat-Kuz. Recently he started working on dissertation of his PhD degree, entitled Development and Estimation of Effectiveness of Combine Treatment in Recurrent Pterigium. He was the author of more than 10 publications. His specializations include Glaucoma, Neuroophthalmology, Pterigium and Pathology of Eye in General Diseases.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 40 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Khera Akshey et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Effectiveness of preliminary laser coagulation of retina in vitroretinal surgery of proliferative diabetic retinopathy Khera Akshey1, Bakhritdinova F A, Bilalov E N and Hodjaeva U Z 1Ophthalmology Clinic Vedanta Medical, Uzbekistan 2Tashkent medical academy, Uzbekistan
Relevance: Diabetic retinopathy is the main cause of irreversible blindness Biography amongst people of working age. Khera Akshey is Head of the Surgical Department in Ophthalmology Clinic Vedanta medical. He has graduated from Tashkent State Medical Objective: The objective of this study was optimization of prophylactic activities institute in 1998. From 1999 to 2001 he was Resident in Department of on prevention of complications of vitreoretinal surgery at proliferative diabetic eye diseases in Tashkent State Medical institute. From 2002 to 2010 he retinopathy (PDR). worked as Ophthalmologist in clinic KO’Z-TIB SERVIS. Then, from 2011 to 2015 he worked as head of the clinic in ORION MEDICITY. He has more Materials & Methods: There have been examined 80 patients (100 eyes) with than 50 publications. In 2018 he successfully protected his dissertation of PhD degree entitled Improvement of Methods of Vitreoretinal Surgery diabetes mellitus (DM) of I and II type, complicated with PDR. All patients in Patients with Proliferative Diabetic Retinopathy and Cataract. He were divided into 2 clinical groups. Group I comprised 58 (58 eyes) patients is an expert in Vitreoretinal Surgery, Diabetic Retinopathy and Retinal with prior panretinal laser coagulation (PLC+) in the III and early IV stages of Detachment. PDR. and Group II consisted of 42 (42 eyes) patients without previous laser [email protected] coagulation (PLC). All patients underwent a full ophthalmological examination. Long-term results were evaluated after 3, 6, 9 and 12 months.
Results & Discussion: Overall, the success of vitreoretinal surgery (restoration of the anatomical structure of the organ - elimination of hemophthalmia and retinal detachment) was in 83.3% (35 eyes) in the PLC group and 94.8% (55 eyes) in the PLC+ group (differences between the groups - P < 0.05). In the course of our studies it was revealed that the previous laser coagulation of the retina in the eyes with proliferative diabetic retinopathy changes the frequency of the indications for vitreoretinal intervention. In the eyes with the previous laser coagulation, there was no combined retinal detachment, there were reliably less frequent shallow detachments of macula and not resorbing hemorrhages. Patients retain a higher visual function, which is known to be a prognostically favorable factor in the functional outcome of the surgery. Another positive predictive effect is the lower incidence of intraocular hypertension in the eyes with the previous PLC. Also, the previous PLC can reduce the time of surgery and reduce the risk of intraoperative hemorrhages. Reduction of the surgery time is associated with a lower volume of intravitreal hemorrhages, less severity of traction, lower demand for using silicone oil and a lower need for intraoperative laser coagulation of retina (due to coagulates).
Conclusions: A significantly positive effect of the preliminary laser coagulation of the retina in the eyes with PDR was revealed even in the conditions of the arising of indications for vitreoretinal surgery. A tendency to reduction of the need for using silicone oil in the eyes with a preliminary laser coagulation of retina has been found.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 41 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Imomalieva K M et al., J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 The assessment of tolerance of the eye medicated film glazavir in the experiment Imomalieva K M, Bilalov E N Tashkent medical Academy, Uzbekistan
Topicality: At present the medical preparations in the form of biodegradable Biography films have been using widely in modern medicine, which allows to prolong K M Imomalieva has graduated from Tashkent Medical Academy in 2014. the effect of medical product and they are indispensable in some cases. On In 2015 she has completed his Masters’degree in Ophthalmology. From the base of experimental investigations of research centre of chemistry and 2015 she is working as the Assistant of the Ophthalmology Department of physics of polymers at National University of Uzbekistan the antiviral eye Tashkent Medical Academy. Recently she started working on dissertation for PhD degree entitled Complex Evaluation of the Effectiveness of medicated films (EMF) GlazAvir containing 10-50% of active starting of inducer Ophthalmic Drug Films in the Treatment of Viral Eye Diseases (clinical and of interferon with antiviral activity TselAgrip was produced.The purpose of experimental study). She was the author of more than 14 publications. study: To study the tolerance of medicated film GlazAvir in the experiment Her specialization includes Inflammatory Diseases of Eye: Conjunctivitis, Keratitis, Scleritis, Uveitis, Glaucoma, Cataract, Pterigium and Medical Preparations of Eye. Material & Methods: GlazAvir presents antiviral EMF, which contains 10-50% active substance (TselAgrip): inductor of interferon with antiviral activity. [email protected] The natural water soluble polysaccharide was used as polymer support in producing EMF. The size of film: length 0.6- 0.9 cm, width 0.3-0.45 cm, thickness 0.004-0.008 cm, mass 0.007-0.015 gm. Studying the tolerance and effect on the functional condition of the healthy eyes, EMF GlazAvir was carried out in 4 (4 eyes) of outbreed rabbits with mass 2.5–3.0 kg, at 6 months by standard methods. During seven days, GlazAvir was placed into conjunctiva cavity of the studying animals once a day. Observation date is one month. With the aim of exception of affected influence of preparation to the cornea, fluorescence sample with the subsequent biomicroscopy, tonometry and pupillometry was carried out and the sensitivity of cornea has been revealed. The tolerance of EMF GlazAvir was studied in general condition of animals by the following parameters: character of behavior (aggressiveness, paleness), external appearance, the condition of woolen cover, mucous membrane, body temperature, appetite, character of discharges, change of the weight.
Results: It was established that daily replacing of EMF GlazAvir into the conjunctival cavity during all term of experimental investigation did not have negative impact on the animal’s eyes and did not make side effects on the general condition of laboratory animals. The result analysis of histological investigations of eye tissue of the animals shows the absence of some path morphological changes from the structure of eye ball.
Conclusion: Developed new EMF GlazAvir can be used in clinical practice in the treatment of viral diseases of eye.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 42 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Zeinab Elsanabary, J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Diagnosis of rare pediatric diseases by Retcam imaging Zeinab Elsanabary University of Cairo, Egypt
etcam imaging is known for its use in early diagnosis of ROP, however, many Biography rare pediatric diseases are detected by its widely professional use. The aim R Dr Zeinab Elsanabary has completed her PhD at the age in 1991 from Cairo of this poster is to highlight the diagnosis of rare conditions as congenital University. She has published about 30 publications as single author or in peripheral active toxoplasmosis (1), Aicardi syndrome showing retinal lacunae collaboration with others and supervised about 35 theses, as Master and (2) and morning glory in infants, papilledema in Down’s syndrome due to Doctorate. She was the Founder and Vise CEO of Bostan Diagnostic Eye Center since 2005, a specialized center for investigative ophthalmology uncommon premature closure of skull fontanelles and sutures leading to which is now a recognized and pioneer center for ophthalmic diagnosis. increased ICT and papilledema and multiple hamartomas in Tuberous sclerosis She was Head of Ophthalmic Diagnostic Laser Unit, Kasr El Eini Hospitals, (3) in infants, to be differentiated from retinoblastoma. Cairo University starting from August 2011 till August 2015. She was assigned as Sub-investigator in a clinical trial about treat and extend in wet AMD (Novartis) in 2013 and Principal investigator in a clinical trial about Diagnosis of these conditions helped in their early management Bematoprost SR implant for glaucoma (Allergan) in 2016 (ongoing). She has teaching duties for junior fellows. She got National Encouraging Award in Advanced Scientific Technology in the Medical Science 2001.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 43 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
S Jafarpour, J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Evaluation of early postoperative ocular pain after photorefractive keratectomy and corneal crosslinking S Jafarpour1 S, Zarei-Ghanavati1 and A Radyn Majd2 1Eye Research Center, Mashhad University of Medical Sciences, Iran 2Taleghani Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Purpose: To evaluate and compare early postoperative pain after photorefractive keratectomy (PRK) and corneal crosslinking (CXL).
Setting: Khatam-al-Anbia Eye Hospital, Mashhad, Iran.
Design: Prospective case series.
Methods: The PRK group included patients with simple refractive errors whereas the CXL group included patients with clinical keratoconus. The groups were compared regarding the level of pain based on the visual analogue scale (VAS), verbal rating scale (VRS), and Wong-Baker FACES pain rating scale immediately after surgery, 6 hours postoperatively; 1, 3, and 7 days postoperatively. The epithelial defect size was measured at 6 hours after surgery and 1 day and 3 days after surgery in both groups.
Results: The study comprised 68 patients (34 patients in the PRK group and 34 patients in the CXL group). The epithelial defect size was significantly smaller in the CXL group than in the PRK group (P< .001); however, the amount of pain was significantly higher after CXL than after PRK based on VAS and VRS (PZ.04 and PZ.019, respectively). In the FACES scaling system, the pain score was also higher in the CXL group than in the PRK group. However, the difference was not statistically significant. No intraoperative or postoperative complications were observed during follow-up.
Conclusions: The epithelial defect healing rate was statistically significantly faster in the CXL group than in the PRK group. However, the level of pain was greater in the CXL group, suggesting that postsurgical pain might be influenced by other factors than the epithelial defect
Figure.1 Comparison of the epithelial defect size between the Figure.2 Comparison of the VRS pain scale between the PRK Figure.3 Comparison of the VAS pain scale between the PRK Figure.4. Comparison of the FACES pain scale between the PRK and CXL groups 6 hours after surgery and 1 and 3 days andCXL groups, showing a higher score in the first 24 hours and CXL groups, showing a higher score in the first 24 hours PRKand CXL groups, showing a higher score for CXL in the first after surgery, indicating a significantly faster healing rate in the after CXL(CXL = corneal crosslinking; PRK = photorefractive after CXL (CXL = corneal crosslinking; PRK = photorefractive 24 hours, although it was not statistically significant (CXL= CXL group (CXL = corneal crosslinking; PRK= photorefractive keratectomy; VRS = verbal rating scale) keratectomy; VAS = visual analogue scale) corneal crosslinking; FACES = Wong-Baker FACES pain scale; keratectomy) PRK =photorefractive keratectomy)
Biography
Soheyla Jafarpour completed her MD at the age of 26 years from Mashhad University of Medical Sciences and attended residency program in ophthalmology for four years thereafter at the same university and graduated in 2016. She passed ICO examinations (Basic sciences, Optics and Refraction and Clinical Ophthalmology) during residency and was certified as FICO by passing the Advanced ICO exam in 2016 after being certified in National board exam. She is a member of Iranian Society of Ophthalmology and a researcher in Eye Research Center, Khatam-al-Anbia Eye Hospital.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 44 Ophthalmology 2018 Accepted Abstracts
World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
Page 46 Ophthalmology 2018 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Latest advancements in computer assisted ophthalmic surgery M Ali Nasseri, Mathias Maier and Chris P Lohmann Augenklinik und Poliklinik, Klinikum rechts der Isar der Technische Universit Munchen, München, Germany
omputer assisted surgery has find its way into ophthalmic procedures in the recent years. In this talk we will discuss computer Cbased approaches with promising solutions for ophthalmic surgery challenges. These approaches include: robotics and smart instrumentation; augmented reality; machine learning; and deep learning. Within this talk, we will investigate state of the art solutions and their potentials to improve the procedures in future. Furthermore, we discuss the challenges including clinical compatibility and training aspects in order to detect obstacles that make translation of these technologies slower.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 47 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Codeine plus acetaminophen for pain after photorefractive keratectomy: a randomized, double-blind, placebo-controlled add-on trial Vinicius B P Pereira, Renato Garcia, Andre A M Torricelli and Samir J Bechara University of São Paulo Medical School General Hospital, University of Sao Paulo, Brazil (VBPP, RG, AAMT, SJB)
Background: Pain after photorefractive keratectomy (PRK) is significant, and the analgesic efficacy and safety of oral opioids in combination with acetaminophen has not been fully investigated in PRK trials.
Objective: To assess the efficacy and safety of the combination of codeine plus acetaminophen (paracetamol) versus placebo as an add-on therapy for pain control after PRK.
Study Design: Randomized, double-blind, placebo-controlled trial.
Setting: Single tertiary center
Methods: One eye was randomly allocated to the intervention, whereas the fellow eye was treated with placebo. Eyes were operated two weeks apart. Participants include adults (>20 years) with refractive stability for ≥1 year, who underwent PRK for correction of myopia or myopic astigmatism. Codeine (30 mg) plus acetaminophen (500 mg) were given orally at 4 times/day for 4 days after PRK. Follow-up is for 4 months. Outcomes are pain scores at 1-72 h as measured by the visual analogue scale (VAS), McGill Pain Questionnaire (MQP) and Brief Pain Inventory (BPI), adverse events (AEs) and cornea wound healing. Trial registration: NCT02625753.
Results: Of the initial 82 eyes, 80 completed the trial (40 interventions, 40 placebos). Median (interquartile range) pain scores as measured by the VAS were statistically and clinically lower during treatment with codeine/acetaminophen compared to the placebo: 1h: 4 (2-4) vs 6 (3-6), p< 0.001; 24 h: 4 (3-6) vs 7 (6-9), p< 0.001; 48 h: 1 (0-2) vs 3 (2-5), p< 0.001; 72 h: 0 (0-0) vs 0 (0-2), p=0.001). Virtually identical results were obtained by the MQP and BPI scales. The most common AEs with codeine/ acetaminophen were drowsiness (42%), nausea (18%) and constipation (5%). No case of delayed epithelial healing was observed in both treatment arms.
Conclusions: When added to the usual care therapy, the oral combination of codeine/acetaminophen was safe and significantly superior to placebo for pain control after PRK.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 48 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Optical coherence tomography-angiography (OCTA) biomarkers correlating disease status in branch vein occlusion Mohamed Attia Ali Minia University, Minia, Egypt
Purpose: To objectively assess the macular vascular flow and density changes together with morphological changes in patients with branch vein occlusion using OCTA automated software algorithms.
Study design: Retrospective observational case series.
Setting: Ophthalmology Department, Minia University Hospitals, Minia, Egypt.
Patients & Methods: 20 eyes from patients having branch vein occlusion (including upper and lower temporal branches) with 20 eyes of normal individuals as control were examined using OCTA (RTVue-XR Avanti; Optovue, Inc, Fremont, CA). Foveal avascular zone (FAZ) area, macular vessel density together with corresponding thickness and visual acuity (expressed as the logarithm of the minimum angle of resolution; Log-MAR) were measured in both groups and statistically compared. Different biomarkers; size of the cleared-out areas, sprouted new collaterals and vascular morphological distortion, could be identified and used to assess severity as well as treatment effects.
Results: The mean FAZ (non-flow) area was significantly enlarged in all patients and showed positive correlation with the Log-MAR visual acuity. Statistically significant negative correlation between flow area and foveal thickness (r=-0.45, p=0.0033). Statistically significant positive correlation between UCVA and foveal thickness (r=0.47, p=0.025).
Conclusion: OCTA provides a non-invasive imaging modality and helpful tool to quantify and follow macular micro-vascular changes in patients with branch vein occlusion; it could settle treatment guidelines based on biomarkers and indices detected in different cases.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 49 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Corneal endothelium damage after phacoemulsification surgery: a specular microscopy study Raghda Faisal Abdelfatah Mutwaly Neelain University, Khartoum, Sudan
Aim: The study aimed to evaluate the effect of phacoemulsification surgery on corneal endothelium cells.
Material & Methods: This prospective cross-sectional study was conducted in Alneelain University Eye Hospital at the Faculty of Optometry and Visual Sciences in 200 patients from Aug’ to Oct’ 2016. The study protocol was approved by the ethical committee of the scientific research deanship at Alneelain University. All patients had senile cataract and underwent phacoemulsification surgery in one eye; their age was 50 years or more. Patients should have endothelium density more than 1000/mm2. Patients with history of systemic disease and ocular trauma should be excluded from the study. A comprehensive clinical examination was performed before cataract surgery and one month after surgery; the examinations were included measurement of visual acuity, outer eye examination and assessment of corneal endothelium cells and central corneal thickness. Then data was analyzed by using statistical package of social sciences (SPSS 20). Descriptive statistics were performed and t-test was used to find correlations between measurements pre and post-surgery.
Results: The study revealed that endothelium cell density was 2178.1±463.9/mm2 before surgery which decreased to 1162.8±519.5/mm2 after surgery with significant difference (P=0.000). Cell number also decreased from (53.24±26.11) pre- surgery to (31.21±20.38) post-surgery (P=0.000). However, the variation between cells size pre-surgery (39.45±12.03) and post- surgery (37.83±15.85) had no significant difference (P=0.521). Furthermore, hexagonality was decreased from 38.26±17.28% pre-surgery to 25.74±24.6% post-surgery with a significant differences (P=0.001). Also, the central corneal thickness showed no significant difference pre-surgery (473.4±27.8µm) and post-surgery (478.7±66.16µm) (P >0.05).
Conclusion: Phacoemulsification damaged more than half of corneal endothelium cells. It also reduced hexagonality and cell number of endothelium.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 50 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Study of lipofuscin granules and melanosomes from human retinal pigment epithelium Mikhail A Ostrovsky Institute of Biochemical Physics, Russian Academy of Sciences, Russia
ipofuscin granules (LGs) accumulate in the retinal pigment epithelium (RPE) cells with age, particularly in patients with Lhereditary diseases. Photosensitization of LGs with blue light can generate reactive oxygen species. Comparative analysis of LGs fluorescence spectra and fluorescence lifetime in the RPE cell suspensions from cadaver eyes with and without signs of AMD showed a clear difference in fluorescence characteristics at 530-580 nm (excitation at 488 nm). Defined differences in fluorescence properties between chloroform extracts obtained from cadaver eyes with and without signs of pathology hold promise for the future improvement of fundus autofluorescence imaging. There is a significant age-related decrease for melanosomes in the RPE cell due to its biodegradation. Oxidants, such as hydrogen peroxide or superoxide radicals, easily lead to melanin destruction. For example, superoxide radicals lead simultaneously both to decrease of melanosomes amount and concentration of paramagnetic centers of the melanin. We suggested that the age-related loss of melanosomes in the RPE cell is due to melanin destruction in the complex melanolipofuscin granules. Superoxide radicals light-induced by LGs causes the destruction. The accumulation of LGs as source of free radicals along with autofluorescence and loss of melanosomes with screening and antioxidant pigment in the RPE cells with age can lead to photo-oxidative stress that is related to the progression of eye pathologies. The lecture reviews the recent advances in knowledge of the RPE lipofuscin granules and melanosomes.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 51 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Full myopic correction on intra ocular pressure (IOP) in young persons Munawar Ahmed Liaquat Univesity of Medical and Health Sciences, Jamshoro, Pakistan
Purpose: To evaluate effects of full myopic correction on intra ocular pressure (IOP) in young persons.
Study Design: Prospective observational clinical study. Place and duration of study: Department of Ophthalmology (LUMHS) from May’ 2014 to May’ 2016
Material & Methods: Using independent simple random sample selection technique 65 patients (15-35 years) of either sex having simple spherical myopia -1.0 to -4.0 D, and IOP 14 to 20 mmHg, wearing glasses for the first time were enrolled for the study. After verbal/written consent initial refraction was done with auto-refractometer followed by subjective correction. IOP was measured with applanation tonometer. Best corrected visual acuity and back vertex distance was noted. Fully corrected prescription using duochrome test was given for full time wear. After one week, the refraction was reconfirmed with glasses, and IOP was measured immediately after removing the glasses. Follow up was done after one month and three months. Each time IOP was measured immediately after removing the glasses.
Results: Out of 65 registered patients 52 completed three months follow up criteria of this study. Among these 52 patients reduction of IOP was observed in 45 (86.54%), and mean reduction of IOP was 2.8790 mmHg (16.7062%). In remaining 7 (13.46%) patients there was no or little response. Only 10 (19.23%) patients complained of eye strain, which was relieved after few days. After three months follow up data was processed on SPSS version 14.0 and p-value was 0.003 (< 0.05), which is quite significant.
Conclusion: Myopia should not be under corrected in young persons, as full correction is more effective in restoring accommodation and reducing IOP than under correction.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 52 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Role of topical cyclosporine 0.05% in prevention of pterygium recurrence, after primary excision Munawar Ahmed Liaquat Univesity of Medical and Health Sciences, Jamshoro, Pakistan
Aim: To reduce the risk of pterygium recurrence after primary excision.
Design and place: Comparative study was conducted at Institute of Ophthalmology LUMHS (IOL) during 2015 -2017.
Methodology: 65 patients having bilateral pterygium, at least 2 mm encroaching on the cornea, were selected for study. After informed consent and explanation of research procedure patient was seen on slit lamp, the dimensions of pterygium was measured. Keratometry was done to assess astigmatism. The eye with more pterygium was selected for post operative cyclosporine and was named as cyclo- eye and fellow eye was selected for simple excision done by the same surgeon after one week interval and was named as simple eye. Immediate post operative treatment was tobramycine dexamethasone eye ointment twice and moxifloxacine three times daily until corneal epithelium was restored, followed by moxifloxacine and cyclosporine eye drops three times daily until complete healing of ocular surface occurred and then cyclosporine 0.05% alone twice daily up to three months. In the fellow eye only tobramycine dexamethazone eye ointment and moxifloxacine eye drops were used for complete healing time. Follow up was done after one week, one month, three months and six months.
Result: 53 patients completed 6 months follow up, remaining will not be discussed, astigmatism was reduced in 100% patients, No recurrence in 42(79.245%) cyclo-eyes however recurrent pterygium was observed in 11(20.754%) cyclo-eyes. Recurrence in fellow simple eyes occurred in 24(45.283%). Cyclosporine was able to reduce pterygium recurrence in 13(54.1666%) eyes. Recurrence rate can further be reduced if maintenance dose of cyclosporine once daily at bed time is used for longer time.
Conclusion: Cyclosporine is effective in reducing the recurrence rate pterygium.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 53 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Regulatory considerations for clinical aspects of ocular drug development - established and surrogate end-points Peter Morgan-Warren Medicines & Healthcare products Regulatory Agency, London, UK
he regulation of ophthalmic medications is a key public health priority, which enables patients to be confident that the Tophthalmic medical treatment they receive is both safe and has a robust evidence base of clinical efficacy. Regulation of ophthalmic products across Europe, in common with all medicinal products, is overseen by the European Medicines Agency (EMA) in conjunction with the national Competent Authorities. In this United Kingdom, this is the Medicines and Healthcare products Regulatory Agency (MHRA), which plays a leading role within the European framework for protecting and improving public health and supporting innovation through scientific research and development. With an increase in the number and complexity of new ophthalmic products and new ophthalmic indications for existing biological, bio similar, cell and gene therapy agents, this represents a considerable regulatory challenge across the European regulatory network. The proposed presentation will cover the following key areas: (1) an overview of regulatory requirements and processes for clinical approval of ophthalmic drugs; (2) trends in clinical trial efficacy end-points; (3) regulatory view on use of biomarkers and surrogate end-points in marketing authorisation submissions; and (4) considerations for rare diseases conditional marketing authorisations and exceptional circumstances.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 54 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Brown Mc Lean Syndrome: a case report Avantika Verma Karthik Netralaya Superspeciality Eye Hospital, Bangalore, India
Purpose: The aim of this study was to report a case of Brown–McLean syndrome (BMS).
Method: A complete ophthalmic evaluation and follow up for a 77 year old patient with BMS.
Result: BMS is a rare condition with corneal edema involving the peripheral cornea with orange-brown pigment deposition underlying the edematous area. The edema typically starts inferiorly and advances circumferentially to superior cornea. Central cornea remains clear in most patients. It requires no further treatment and annual follow-ups are adequate.
Conclusion: Patients with BMS can rarely progress to corneal decompensation; however, they should be periodically monitored and made aware of early clinical symptoms and signs of ocular surface complications.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 55 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Comparison of visual outcomes and complications of posterior chamber phakic intraocular lens with and without a central hole implantation for correction of high myopic astigmatism Seyed Javad Hashemian M Iran University of Medical Sciences, Iran
Background: To evaluate the visual outcomes and complications after implantation of new Visian Implantable Collamer Lens (ICL) V4c (with centraflow technology) and conventional V4 ICL for correction of high myopia and myopic astigmatism
Purpose: To evaluate the visual outcomes and complications after Visian Implantable Collamer Lens (ICL) implantation V4c (with centraflow technology) and V4b for correction of high myopia and myopic astigmatism.
Setting: Eye research centre, Rassoul Akram Hospital, Iran University of Medical Sciences and Iranian Eye Clinic, Tehran, IRAN.
Design: Retrospective, comparative interventional case series
Materials & Methods: A retrospective, comparative interventional case series of V4c and V4b ICL implantation done for correction of high myopia and astigmatism. The outcome measures that were evaluated included preoperative and postoperative uncorrected and corrected distant visual acuity (UDVA), (CDVA), endothelial cell count (ECC), presence of lens opacification, intraocular pressure (IOP) and lens rotation. A follow-up of upto one year was done.
Results: 46 eyes underwent V4c ICL with centraflow implantation and 40 eyes had implantation of V4b ICL with intraoperative peripheral iridectomy (PI). The mean preoperative manifest spherical equivalent (MSE) was -8.65±2.8 D and -8.51±3.6 D in the V4c and V4b groups respectively which reduced to postoperative values of -0.16± .34 D and -0.33±.41 D respectively. The mean preoperative astigmatism was -1.38±1.3 D and -1.65±1.14 D that respectively reduced to -0.51±0.48 D and -0.46±0.37 D. At the end of 1 year follow up, mean ECC loss was 2.41% and 3.17%, respectively in the V4c and V4b groups. No anterior subcapsular opacities were seen in both groups. One eye of V4c (2.2%) and three eyes of V4b (7.5%) group requires re-rotation surgery. The safety indices were 1.21 and 1.32 and efficacy indices were 1.15 and 1.21 in the V4c and V4b groups respectively at the end of one year.
Conclusions: Both V4c and V4b visian ICL implantations have same result in terms of visual outcome and safety profile for correction of high myopia and astigmatism. However, In V4c ICL implantation peripheral iridectomy doesn’t require.
Precis: Both V4c and V4 Visian ICL implantations are comparable in terms of visual outcome and safety profile for correction of high myopic astigmatism. However, V4c ICL offers these advantages without the requirement of an additional PI.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 56 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Visual and refractive outcomes of the unilateral SUPRACOR multifocal corneal LASIK procedure for the correction of hyperopia and presbyopia Seyed Javad Hashemian M Iran University of Medical Sciences, Iran
Background: To analyze the clinical outcomes after unilateral Supracor multifocal corneal Femto-LASIK in non-dominant eye for the correction of hyperopia and presbyopia.
Purpose: To assess the visual and refractive outcomes and complications of unilateral SURACOR multifocal corneal Femto-LASIK in non-dominant eye for the correction of hyperopia and presbyopia.
Setting: Eye research centre, Rassoul Akram Hospital, Iran University of Medical Sciences and Iranian Eye Clinic, Tehran, Iran.
Design: Prospective case series.
Methods: This study enrolled 26 eyes of 13 patients who had bilateral femto-LASIK for the correction of hyperopia plus SURACOR multifocal corneal Lasik in non-dominant eye. Monocular and binocular uncorrected (UDVA) and corrected distance visual acuity (CDVA), monocular and binocular uncorrected (UNVA) and distance-corrected near visual acuity (DCNVA) at 40 cm, Central corneal power and High order aberrations changes and complications were evaluated over 6 months.
Results: Mean age was 51.77±3.74 years (range: 48 to 60 years). Mean postoperative spherical equivalent refraction was -0.07±0.47 diopters (D) for dominant eyes and -0.85±0.43 D for non-dominant eyes. Mean binocular UDVA was 20/25 at 6 months. Mean binocular UNVA was Jaeger 2 at 6 months. At 6 months, 100% of patients achieved 20/25 and could read Jaeger 2 binocularly. Mean non-dominant eye UDVA was 20/40 at 6 months. The mean central keratometry steepening was 2.54 D. There were significantly more negative spherical aberration and vertical coma in the central 6 mm postoperatively (P<.05). 98% of these patients did not need any glasses for distance and near vision.
Conclusions: Supracor procedure in non-dominant eye may improve functional near, intermediate, and distance vision without significant photic phenomena in presbyopic patients with low and moderate hyperopia.
Précis: Supracor procedure in non-dominant eye provided good refractive and visual outcomes at far, intermediate, and near distances without significant photic phenomena in presbyopic patients with low and moderate hyperopia.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 57 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Traumatic brain injury and post trauma vision syndrome Tina D Aldana United States Army, USA
raumatic brain injury (TBI) is a complex pathophysiological process induced by biomechanical forces that affect the brain and Tnegatively impacts an individual's activities of daily living. This presentation will provide an introduction to the mechanism of the neurological injury as well as discuss the signs and symptoms of the most common visual disorders related to TBI. At the conclusion of this lecture, the participant will understand TBI and the mechanism of injury, learn the prevalence of TBI and concussion-related vision disorders, and recognize the signs and symptoms of the most common visual disorders related to TBI.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 58 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Are we still lagging behind in preventing blindness in patients with ocular leprosy in post elimination era? Manik Gupta TLM SHAHDARA, India
Introduction: Frequency and severity of ocular involvement in cases of leprosy is directly proportional to the duration, degree of advancement of the disease and the treatment status of the patient. On account of lengthy duration of the illness, it invariably produces ocular disabilities. Visual impairment culminating in total loss of vision is a major tragedy in the life of a patient with leprosy. This visual disability is to a large extent preventable; provided the ocular involvement is diagnosed at an early stage and appropriate measures are undertaken in time. It should be realized that loss of vision is the same handicap to the patient, whether due to leprosy or to other causes not related to leprosy. Severe visual impairment or blindness may hamper or preclude self-care and is, therefore, more disabling in leprosy patients than in the general population. Blindness for leprosy patients is really a disaster. They completely depend on eye sight to protect their often anaesthetic limbs from injuries and burns.
Methods & Materials: This is an observational prospective study involving 150 patients suffering from leprosy who attended ophthalmic outpatient department from Jan’ 2017 to June’ 2017 in TLM Community Hospital Shahadara. Complete ophthalmic examination was performed and patients were classified according to ocular pathology.
Observation: A total of 150 consecutive leprosy patients attending their ophthalmic visit were examined, out of which 30 patients were blind in one eye (20%) and 10 patients were blind in both the eyes (6.6%). Visual acuity of 6/18 was present in 60 patients (40%). A total of 90 patients (60%) had an ocular complication and 30 patients (20%) had a sight-threatening leprosy complication (lagophthalmos, severe corneal, or iris disease). The most common ocular complications were impaired lid closure (28 patients, 18.66%), impaired corneal sensation (24patients, 16%), cataract (30 patients, 20 %), mild corneal opacity (40 patients, 26.66%), and iritis (20 patients, 13.33 %). Impaired corneal sensation was associated with vision <6/18 (16 patients, 10.66%) and vision <3/60 (12 patients, 8%). Impaired lid closure was significantly associated with increasing age and vision <3/60 (14 patients, 9.3 %).
Conclusion: There is a significant rate of ocular complications and blindness seen in leprosy patients, and over one in five had a potentially sight-threatening ocular complication. Health professionals and all leprosy patients, including those cured of the disease need to be aware that new eye symptoms and signs require prompt ophthalmology review to prevent avoidable blindness, due to the life-long risk of sight-threatening ocular complications
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 59 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Effect of visual acuity and stereopsis on ocular deviation Partha Haradhan Chowdhury Gujarat University, Ahmedabad, India
Aim: The aim of the present study is to co relate visual acuity and stereopsis on ocular deviation
Methods: A pilot, cross sectional, non-randomized study was performed at tertiary eye care centres within a period of one year. The study was approved by ethics committee of SSJS. Visual acuity, and stereopsis were assessed statistically using microsoft office excel and SPSS software version 20 in cases of ocular deviation
Results: In cases of ocular deviation, mean values of visual acuity and steropsis are 0.196 log units and 80 seconds of ARC respectively which shows significant deterioration
Conclusion: Ocular deviation significantly deteriorates the visual acuity and srereopsis
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 60 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Functional vision with X chrome lenses Partha Haradhan Chowdhury Gujarat University, Ahmedabad, India
Purpose: To implement x chrome lens in children
Methods: A pilot, cross sectional study was performed in the tertiary eye centre during the period of one year. Functional vision like visual acuity, contrast sensitivity, stereopsis and color vision of 10 existing X chrome soft contact lenses users were analyzed with and without lenses.
Results: Visual functions were compared statistically using paired t test with SPSS 20 software. Negligible change observed in visual acuity and contrast sensitivity with p value of 0.015 and 0.010 respectively. No change is observed in stereopsis. Ishihara shows normal color vision with x chrome lenses while D-15 test shows reduction in severity of color vision deficiency.
Conclusions: If X chrome color contact lenses are implemented during child’s learning period, it will eliminate many of the academic challenges that are faced with color coded learning and teaching materials and improve their quality for many recreational activities
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 61 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Keratoconus: etiopatogenesis, real cure and microsurgical corneal correction Massimo Lombardi Centro di Medicina Rigenerativa Oculistica, Roma- Italia
he author presents the discovery of fungal corneal infection as responsible of the origin and progression of Kertoconus Tsickness followed up with the already experimented biological Treatment that gives a definitive resolution to ectasia- progression and finally the Micro-Surgical-Corneal-Incisional-Technique, that has demonstrated (up to now a day), that this technique (presented for the first time at “Atlanta ISRS Congress in 1995”) is still the only realiable one (after 35 years of “Follow Up”), that can give an “Implosive“ and “Flattening” corneal effect, to correct permanently the refractive secondary error and to restore a definitive Sight Recover
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 62 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Retinal stem cells reprogramming Massimo Lombardi Centro di Medicina Rigenerativa Oculistica, Roma- Italia Lombardi Eye Clinic, Italy A new therapeutic method of Regenerative Ophtalmic Medicine. A Homotoxicological Pharmaceutical blend therapy through retrobulbar injections
report my experience derived, 10 years ago, from his first autologous stem cells live explantation from “Mallow Bone” (through I the Hip) and re-implantation into the retrobulbar fat of the eye. To define a new concept of “Re-Informational Therapy” for “Rigenerative Ophtalmic Medicine” using a system for “Reformatting” - pathological eye tissues as retina or uvea or cornea or optic nerve through the therapeutical “Re-regulation”of affected tissues of the inner eye no more capable to spontaneously regulating its normal biological functions. I report my capability to stimulate the regeneration not only of autologous eye stem cells but also unwillingly of totipotent autologous stem cells having cured Anosmia cases and Acustic nerve deficiency cases while I was curing optic nerve, retina or uvea or Cornea pathologies. I could also define in this work the complete real mechanism of formation, transportation and storage of biological infos through the water memory giving a definition of the whole computer like biological life into a “Multiverso” that it is the multidimensional olografic Universe
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 63 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Association between blood pressure and retinal arteriolar and venular diameters in Chinese early adolescent children, and whether the association has gender difference: a cross-sectional study Ningli Wang1, Yuan He, Shi-Ming Li1, Meng-Tian Kang1, Luo-Ru Liu2, He Li2, Shi-Fei Wei1, An-Ran Ran1and the Anyang Childhood Eye Study Group 1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China 2Anyang Eye Hospital, Anyang, Henan, China
Background: To establish the independent association between blood pressure (BP) and retinal vascular caliber, especially the retinal venular caliber, in a population of 12-year-old Chinese children.
Methods: We have examined 1501 students in the 7th grade with mean age of 12.7 years. A non-mydriatic fundus camera (Canon CR-2, Tokyo, Japan) was used to capture 45° fundus images of the right eyes. Retinal vascular caliber was measured using a computer-based program (IVAN). BP was measured using an automated sphygmomanometer (HEM-907, Omron, Kyoto, Japan).
Results: The mean retinal arteriolar caliber was 145.3 μm (95% confidence interval [CI], 110.6–189.6 μm) and the mean venular caliber was 212.7 μm (95% CI, 170.6–271.3 μm). After controlling for age, sex, axial length, BMI, waist, spherical equivalent, birth weight, gestational age and fellow retinal vessel caliber, children in the highest quartile of BP had significantly narrower retinal arteriolar caliber than those with lower quartiles (P for trend< 0.05). Each 10 mmHg increase in BP was associated with narrowing of the retinal arterioles by 3.00 μm (multivariable-adjusted P<0.001), and the results were consist in three BP measurements. The association between BP measures and retinal venular caliber did not persist after adjusting for fellow arteriolar caliber. And there was no significant interaction between BP and sex, age, BMI, and birth status.
Conclusions: In a large population of adolescent Chinese children, higher BP was found to be associated with narrower retinal arterioles, but not with retinal venules. Sex and other confounding factors had no effect on the relationship of BP and retinal vessel diameter,.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 64 World Congress on Ophthalmology & Eye Surgery
August 16-17, 2018 Paris, France
J Eye Cataract Surg 2018, Volume: 4 DOI: 10.21767/2471-8300-C2-006 Changes in the lacrimal gland, ultrasonographic features Markosyan Armida Grishai GVM Care and Research Medical Center, Russia
he human lacrimal gland combines two functions: exocrine and immune surveillance in orbit. The combination of two important Tphysiological functions explains the high frequency of involvement of this glandular organ in various pathological processes: inflammatory, autoimmune and neoplastic. Clinical symptoms of these diseases at certain stages of development are so similar that it is sometimes not possible to differentiate one process from another on the basis of one clinical picture. Meanwhile, for the diagnosis and determination of adequate tactics of therapeutic measures, the assessment of the state of the lacrimal gland is necessary.
Material & Methods: The study is based on clinical and functional investigation of 120 patients (240 orbits) during 2005-2018 years. The age of participants ranged from 13 to 75 and averaged 45.1 years. Women prevailed in numbers (66%), while men constituted only 34%. Physical, laboratory, and instrumental examinations includes transbronchial lymph node biopsy, MRI and СТ.
Results & Discussion: The unchanged lacrimal gland was defined as an elongated moderately-hypo-echogenic structure located in a space limited by ultrasound sections of the upper-outer edge of the orbit and the eyeball, while depending on the shape and size of this space, it occupied a different longitudinal position, transverse and oblique most commonly found longitudinal location of the lacrimal gland. Form of the lacrimal gland on the ultrasound section irregular oval, triangular, pear. Lacrimal gland was separated from the surrounding tissues by a narrow moderate-hyperechogenic capsule. Echographic features of the lacrimal gland in disease and Sjogren's syndrome. Examined were 35 patients, the average age of patients were 49±17 years, and among the examined patients prevailed females (87.2%) in all patients of this group the diagnosis was verified on the basis of the results of clinical and laboratory instrumenter survey. 12 patients were visualized precise contours of the lacrimal glands; in 23 cases, the lacrimal glands did not have clear contours; in 2 patients, the capsule surrounding the lacrimal glands was well traced in most patients of this group (23 people), a significant decrease in the size of the lacrimal glands, an increase in their density, a decrease in the vasculogenesis index. Echographic features of the lacrimal gland in acute dacryoadenitis. 15 people with clinical manifestations of acute unilateral dacryoadenitis. Lacrimal gland was visualized in the form of moderately hypoechogenic, often with indistinct contours and inhomogeneous echostructure. In all cases there was an increase in the size of the lacrimal gland with normal values of the average longitudinal size was 2.08±0.22 cm, the transverse dimension of 1.07±0.17 cm figure, ultrasonic density ranged from 58 to 69 UE, and averaged 60±11.1
Conclusion: Modern diagnostic ultrasound technologies also provide the opportunity for intravital assessment of the lacrimal gland and evaluation of possible changes in its condition. They allow measuring dimensions of the gland, determining its shape and structure, as well as topographic relationship with other orbital structures. Different systemic diseases, can affect the gland both directly and indirectly, causing structural changes in its tissue or a functional reaction, characteristic for organs of immune surveillance.
Journal of Eye & Cataract Surgery Ophthalmology 2018 ISSN: 2471-8300 Page 65