WELCOME ! On behalf of the ECCB10 Organizing and Steering Committees we would like to welcome you to beautiful Ghent, one of Europe’s most exciting cities. We hope you will enjoy ECCB10 - four days of presentations, poster sessions, workshops, software demonstrations and networking with other leading bioinformatics researchers, computational biologists and bio-IT professionals from around the world. ECCB is the leading European meeting in our field and a primary international conference at which people present and discuss advances in computational biology. We are proud to have five keynote lectures by distinguished speakers Peer Bork (European Molecular Biology Laboratory, Heidelberg, Germany), Elaine Mardis (Washington University Genome Center, St-Louis, MO, USA), Michael J. E. Sternberg (Imperial College, London, UK), Yves Van de Peer (Flemish Institute of Biotechnology and University of Ghent, Belgium) and Hans Westerhoff (University of Manchester, UK and VU University Amsterdam, The Netherlands). In addition, there will be a number of interesting workshops and tutorials on Sunday, including the first European Student Council Symposium, a workshop on leveraging perturbation effects towards reverse engineering biological networks and one on extraction and reuse of genotype-phenotype knowledge from scientific literature and databases. There is no better way to kick off ECCB10 than to participate in one of these workshops and tutorials! On Monday afternoon, we will have a special joint lecture by artist Koen Vanmechelen and geneticist Jean- Jacques Cassiman. They will present the Cosmopolitan Chicken Project – Koen’s quest to create a universal, cosmopolitan chicken. Further, they will discuss how art and science influence each other. We would like to acknowledge the help of all people who made ECCB10 happen, as well as our commercial and academic sponsors – thanks to them we were able to offer 62 fellowships for early-stage scientists. Finally, we would like to thank you for your participation. Enjoy the conference! Yves Moreau & Jaap Heringa ECCB10 Table of Contents TABLE OF CONTENTS Hotels ...................................................................................................................................................................... 4 Local Public Transport ........................................................................................................................................... 5 Floor Plan ............................................................................................................................................................... 6 Organization ........................................................................................................................................................... 7 Keynotes ............................................................................................................................................................... 15 Schedule ............................................................................................................................................................... 17 Social Events ........................................................................................................................................................ 25 Workshops ............................................................................................................................................................ 26 Tutorials ................................................................................................................................................................ 29 Art Meets Science ................................................................................................................................................. 34 Technology Track ................................................................................................................................................. 35 Oral Presentations ................................................................................................................................................. 45 Posters .................................................................................................................................................................. 61 Author Index ....................................................................................................................................................... 102 3 ECCB10 Hotels HOTELS NH Gent Sint Pieters Hotel Novotel Gent Centrum Koning Albertlaan 121, 9000 Ghent, Belgium Goudenleeuwplein 5, 9000 Ghent, Belgium +32 9 222 60 65 +32 9 224 22 30 Holiday Inn Gent Expo Carlton Hotel Gent Maaltekouter 3, 9051 Ghent, Belgium Koningin Astridlaan 138, 9000 Ghent, Belgium +32 9 220 24 24 +32 9 222 88 36 NH Gent Belfort Hostel 47 Hoogpoort 63, 9000 Ghent, Belgium Blekerijstraat 47, 9000 Ghent, Belgium +32 9 233 33 31 +32 478 71 28 27 Ghent Marriott Hotel HI De Draecke Gent Korenlei 10, 9000 Ghent, Belgium Sint-Widostraat 11, 9000 Ghent, Belgium +32 9 233 93 93 +32 9 233 70 50 Hotel Gravensteen Ecohostel Andromeda Jan Breydelstraat 35, 9000 Ghent, Belgium Bargiekaai 35, 9000 Ghent, Belgium +32 9 225 11 50 +32 486 67 80 33 Ghent River Hotel Waaistraat 5, 9000 Ghent, Belgium +32 9 266 10 10 Hotel de Flandre Poel 1, 9000 Ghent, Belgium +32 9 266 06 00 Hotel Ibis Gent Centrum Opera Nederkouter 24-26, 9000 Ghent, Belgium +32 9 225 07 07 Hotel Ibis Centrum St-Baafs Kathedraal Limburgstraat 2, 9000 Ghent, Belgium +32 9 233 00 00 Holiday Inn Gent Express Akkerhage 2, 9000 Ghent, Belgium +32 9 222 58 85 Campanile Akkerhage 1, 9000 Ghent, Belgium +32 9 220 02 22 Poortackere Monasterium Oude Houtlei 58, 9000 Ghent, Belgium +32 9 269 22 30 4 ECCB10 Local Public Transport LOCAL PUBLIC TRANSPORT Basics ‘De Lijn’ (http://www.delijn.be) provides trams and buses in Ghent. Using public transport is easy and travelers are offered several ticket options, but in any case buying your ticket in one of the distribution points (train station, kiosks, supermarkets…) is at least 25% cheaper than buying it from the bus or tram driver. If you are considering taking several bus/tram trips you might be interested in the “lijnkaart”, which grants the owner 10 trips at a discount rate. People traveling in groups of 5 or more can buy a “lijnkaart %” which also provides 10 trips at an even lower rate. If you plan on using public transportation a lot, a day-pass or a 3-day-pass might be the most convenient way of traveling through Ghent. Once you have bought a ticket traveling is as simple as getting on the bus, saying “Goeiedag!” to the driver and inserting the ticket into the yellow validation device (don’t forget to take it back). Transfers are allowed for one hour after validation. Ticket Type Price at distribution point Price on the bus/tram Single ticket € 1,20 € 2 Lijnkaart (10 trips) € 8 € 15 Lijnkaart % (10 trips) € 6 € 11 Day-pass € 5 € 6 3-day-pass € 10 € 12 Museum Pass (3-day-pass, includes access to the city’s museums): € 20 From the conference site to the city centre Bus 5 is a convenient way to go to the city centre. It leaves from the bus stop in front of the conference site. You will find a map of public transport in the conference bag. Ghent Museum Pass The Ghent Museum Pass costs € 20 and offers access to various museums and municipal buildings for 3 days. During those 3 days the Ghent Museum Pass is also valid as a ticket for all De Lijn vehicles in the Ghent city area. The validity period starts on the date that you write on the back of the pass. You can purchase a Ghent Museum Pass in advance and use it for your journey to the first museum. You can purchase the Ghent Museum Pass in the Lijnwinkels in East Flanders, in participating museums, from the tourism department of the city of Ghent, and in several Ghent hotels. The participating museums and municipal buildings are: Belfry, Friary of the Carmelites, Design Museum Ghent, De wereld van Kina: the Garden, De wereld van Kina: the House, The Castle of the Counts, Alijn House, Art Centre St Peter’s Abbey, MIAT (Museum for Industrial Archaeology and Textiles), Museum Dr. Guislain, Museum for the History of the Sciences, Museum of Fine Arts, St Bavo's Cathedral + The Adoration of the Mystic Lamb, SMAK (City Museum for Modern Art), STAM (City Museum Ghent). More information available at De Lijn's website (http://www.delijn.be/en/vervoerbewijzen/types/uitstap/#5). 5 ECCB10 Floor Plan FLOOR PLAN 6 ECCB10 Organization ORGANIZATION Conference Chair Yves Moreau, Katholieke Universiteit Leuven, Belgium Proceedings Chair Jaap Heringa, VU University Amsterdam, The Netherlands Local Organizing Committee Yves Moreau, Katholieke Universiteit Leuven, Belgium Jaap Heringa, VU University Amsterdam, The Netherlands Gert Vriend, Radboud University, Nijmegen, The Netherlands Yves Van de Peer, University of Ghent and VIB, Belgium Kathleen Marchal, Katholieke Universiteit Leuven, Belgium Jacques van Helden, Université Libre de Bruxelles, Belgium Louis Wehenkel, Université de Liège, Belgium Antoine van Kampen, University of Amsterdam and Netherlands Bioinformatics Center (NBIC) Peter van der Spek, Erasmus MC, Rotterdam, The Netherlands Steering Committee Michal Linial (Chair), Hebrew University, Jerusalem, Israel Soren Brunak, Technical University of Denmark, Lyngby, Denmark Philipp Bucher, University of Lausanne, Switzerland David Gilbert, University of Glasgow, UK Thomas Lengauer, Max-Planck Institute for Informatics, Saarbrücken, Germany Yves Moreau,