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HARMFUL ALGAE 2018 – FROM ECOSYSTEMS TO SOCIO-ECOSYSTEMS PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON HARMFUL ALGAE 21-26 October 2018, Nantes, France 1 ISBN 978-87-990827-7-3 HARMFUL ALGAE 2018 – FROM ECOSYSTEMS TO SOCIO-ECOSYSTEMS PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON HARMFUL ALGAE 21-26 October 2018, Nantes, France Editor: Philipp Hess (Ifremer) Graphic design : MCI France Lay-out : Hélène Parfait (Ifremer) Published by the International Society for the Study of Harmful Algae (ISSHA) and the Institut Francais de Recherche pour l'Exploitation de la Mer (Ifremer), in cooperation with the Intergovernmental Oceanographic Commission of the United Nations Educational, Scientific and Cultural Organization (IOC/UNESCO). For bibliographic purposes, this document should be cited as follows: Ph. Hess [Ed]. 2020. Harmful Algae 2018 – from ecosystems to socioecosystems. Proceedings of the 18th Intl. Conf. on Harmful Algae. Nantes. International Society for the Study of Harmful Algae. 214 pages. ISBN: 978-87-990827-7-3. DISCLAIMER Authors are responsible for the choice and the presentation of the facts contained in signed articles and for the opinions expressed therein, which are not necessarily those of ISSHA, IOC/UNESCO or Ifremer and do not commit these organizations. The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of Ifremer, ISSHA or UNESCO concerning the legal status of any country, territory, city or area or of its authorities or concerning the delimitation of its frontiers or boundaries. 1 2 Hosted by Institut Français de Recherche pour l’Exploitation de la Mer (Ifremer) Convener Philipp Hess, Ifremer Centre Atlantique, Nantes, France Under the auspices of The International Society for the Study of Harmful Algae (ISSHA) COMMITTEES Local organizing committee Anthony MASSE Maud LEMOINE Sophie PILVEN Université de Nantes, France Ifremer, France Ifremer, France Gaël BOUGARAN, Patricia THIBAULT-PRALIN Véronique SECHET Ifremer, France Ifremer, France Ifremer, France Hélène PARFAIT Philipp HESS Zouher AMZIL Ifremer, France Ifremer, France Ifremer, France Scientific Committee (reviewers underlined) Allan CEMBELLA Claudia WIEGAND Alfred-Wegener-Institut, Germany Université de Rennes 1, France Amel LATIFI Clémence GATTI Aix Marseille Université, France Institut Louis Malardé, France Anne THEBAULT Damien TRAN Agence nationale de sécurité sanitaire de l’alimen- Université de Bordeaux, France tation, de l’environnement et du travail, France Delphine LATOUR Annick WILMOTTE Université Blaise-Pascal de Clermont-Ferrand, Université de Liège, Belgium France Anthony MASSE Felipe ARTIGAS Université de Nantes, France Université Littoral Côte d’Opale, France Benjamin MARIE Gaël BOUGARAN Muséum National d’Histoire Naturelle, France Ifremer, France Catherine BELIN Hélène HÉGARET Ifremer, France Université de Brest, France Catherine DREANNO Jean-François HUMBERT Ifremer, France Université Pierre et Marie Curie, France Catherine QUIBLIER Jean-Luc ROLLAND Museum National d’Histoire Naturelle, France Ifremer, France Cécile BERNARD Jordi MOLGO Museum National d’Histoire Naturelle, France Institut des Neurosciences Paris-Saclay, France 3 Juliette FAUCHOT Nicolas CHOMERAT Université de Caen, France Ifremer, France Laure GUILLOU Philipp HESS Station biologique de Roscoff, France Ifremer, France Marc SOURISSEAU Philippe SOUDANT Ifremer, France Université de Brest, France Marie BONNIN Raffaele SIANO Institut de Recherche pour le Développement, Ifremer, France France Rodolphe LEMÉE Marie-Yasmine DECHRAOUI-BOTTEIN Observatoire océanologique de Villefranche sur International Atomic Energy Agency, Monaco Mer, France Mathilde PALUSSIERE Romulo ARAOZ DGAl/Bureau des Produits de la Mer et de l’Eau Commissariat à l’Energie Atomique, France Douce, France Ronel BIRÉ Maud LEMOINE Agence nationale de sécurité sanitaire de l’alimen- Ifremer, France tation, de l’environnement et du travail, France Mélanie ROUE Sophie PARDO Institut de Recherche pour le Développement, Université de Nantes, France France Valérie FESSARD Mireille CHINAIN Agence nationale de sécurité sanitaire de l’alimen- Institut Louis Malardé, France tation, de l’environnement et du travail, France Mohamed LAABIR Véronique MARTIN-JEZEQUEL Université de Montpellier, France Université de Nantes, France Muriel GUGGER Véronique SECHET Institut Pasteur, France Ifremer, France Myriam BORMANS Zouher AMZIL Université de Rennes 1, France Ifremer, France Nathalie ARNICH Agence nationale de sécurité sanitaire de l’alimen- tation, de l’environnement et du travail, France International Advisory Board (reviewers underlined) Aifeng LI Beatriz REGUERA* Esther GARCÈS* China Spain Spain Allan CEMBELLA Charles LUGOMELA Grant PITCHER Germany Tanzania South Africa Ana GAGO Christine BAND-SCHMITT Gustaaf HALLEGRAEF* Spain Mexico Australia Asma HAMZA Don ANDERSON Henrik ENEVOLDSEN* Tunisia USA Denmark Bastiaan Willem IBELINGS Emanuela TESTAI Ian JENKINSON* Switzerland, Netherlands Italy China, France 4 Lincoln MACKENZIE* Patricia TESTER Sun Ju KIM New Zealand USA Republic of Korea Lirong SONG Philipp HESS* Takeshi YASUMOTO China France Japan Luis BOTANA Rainer KURMAYER Triantafyllos KALOUDIS Spain Austria Greece Luis PROENCA Rencheng YU Vera TRAINER* Brazil China USA Marie-Yasmine Robin RAINE* DECHRAOUI-BOTTEIN Ireland *members of the ISSHA Council Monaco Sandra SHUMWAY Conference Organizing Sub- committee USA Mitsunori IWATAKI Japan Songhui LU China ADDITIONAL PROCEEDINGS REVIEWERS Adriana ZINGONE Leila BASTI Raphe KUDELA Stazione Zoologica Anton Tokyo University of Marine University of California, Dohrn Napoli, Italy Science and Technology, Santa Cruz, USA Japan Antonella PENNA Robert HATFIELD Università degli Studi di Luiz MAFRA Urbino Carlo Bo, Italy Universidade Federal do Centre for Environment, Fisheries and Aquaculture Paraná, Brazil Bengt KARLSON Science, UK Swedish Meteorological and ØJvind MOESTRUP Hydrological Institute, University of Copenhagen, Urban TILLMANN Sweden Denmark Alfred Wegener Institute, Germany Elisa BERDALET Patrice GUILLOTREAU Institut de Ciències del Mar, Université de Nantes, Uwe JOHN Spain France Alfred Wegener Institute, Germany Fran VAN DOLAH Po Teen LIM National Oceanic and University of Malaya, Wayne LITAKER Atmospheric Malaysia National Oceanic & Administration, USA Atmospheric Raphaele LE GARREC Administration, USA Keith DAVIDSON Université de Bretagne Scottish Association for Occidentale, France Marine Science, Scotland 5 PARTNERSHIPS Bronze sponsors Other sponsors French Research Project ANR OSS-Cyano Cambridge Isotope Laboratories Marine Drugs Cifga McLane Cytobuoy B.V. Phytoxigene Fluid Imaging Technologies Synoxis Algae IKA Werke GmbH & Co. KG Jerico-Next Marine Institute Merck KGaA Novakits Abraxis Photon Systems Instruments Statera Environmental Station Ifremer Concarneau French Institutional Support Institut Français de Recherche pour l’Exploitation de la Mer (Ifremer) GdR Phycotox (Ifremer – CNRS 3569) Agence Française pour la Biodiversité (AFB) Commissariat à l'énergie atomique et aux énergies alternatives (CEA) Museum National d’Histoires Naturelles Nantes Métropole Université Bretagne Loire Institut Universitaire Mer et Littoral (IUML) International Institutional Cooperation International Atomic Energy Agency (IAEA) U.S. National Institute of Environmental Health Sciences (NIEHS) Scientific Committee on Oceanic Research (SCOR) U.S. National Oceanic and Atmospheric Administration (NOAA) 6 EDITOR’S PREFACE The 18th International Conference on Harmful national scientific committee built on GdR Algae (ICHA) was held at La Cité des Congrès, Phycotox and GIS Cyano (43 people). Overall Nantes, France, 21-26 October 2018. After the feedback on this ambitious program was very last conference in the same spot 25 years positive (87 participants (12%) replied to our earlier, this was the second time the conference feedback questionnaire: 80% of the was convened in France. The conference was respondents found the scientific program good hosted by Ifremer and was born from an or excellent). We heavily drew on the ISSHA initiative of the French marine HAB research council, our national scientific committee and community (GdR PHYCOTOX), with strong other key scientific members of our community support by its sister organization for freshwater for our 53 session chairs – again, thank you all cyanobacteria (GIS Cyano). The theme of the for helping us in this event! conference “From Ecosystems to I also acknowledge the help of our reviewers of Socioecosystems” was chosen to stress the the 47 submissions to the proceedings (> 90% need to integrate natural sciences with social reviewed by 2 referees). A frustrating aspect of sciences to increase the impact of our science conference proceedings is the change in on society. A short summary of the event and a publication attitude of conference attendees. scientific summary have already been published While most participants contributed to the in Harmful Algae News (pages 1-8, issue 62; conference proceedings in 1989 (100 June, 2019). contributions), less than 8% of contributions to Compared to previous conferences, this edition the conference in 2018 resulted in 47 has enjoyed record attendance (709 participants submissions to the proceedings. This lack in from 64 countries) and scientific contributions participation to the proceedings obviously (613 abstracts, with 255 oral presentations and results from the need for “measurable
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  • A A–803467, 98 Absorption, Distribution, Metabolism, Elimination

    A A–803467, 98 Absorption, Distribution, Metabolism, Elimination

    Index A Anxiety disorders, 55 A–803467, 98 APD. See Action potential duration Absorption, distribution, metabolism, Arrhythmias, 45, 46 elimination and toxicity Aryl sulfonamido indanes, 126–128, 130 (ADMET), 193 ATP-sensitive potassium channels (KATP Absorption, distribution, metabolism, channels), 61 excretion, and toxicity Atrial effective refractory period (AERP), 122, (ADMET), 68 124–126, 128, 129, 132, 138 Acetylcholine binding protein (AChBP), Autoimmune diseases, 254 61, 62, 64 AZD7009, 101 Acetylcholine receptor (AChR), 57, 64 Azimilide, 139 Action potential duration (APD), 120, 122, 123, 128, 132 B Action potentials, 243, 256, 259 Basis set, 69–70 ADME/T, 299, 304 b-Barrel membrane proteins AERP. See Atrial effective refractory period genome-wide annotation, 13 Agitoxin (AgTX), 60 machine-learning techniques Agonists, 59–61, 64 residue pair preference, 11 Alinidine, 40–42 TMBs, 10 ALS. See Amyotrophic lateral sclerosis pipeline, genomic sequences, 14 Alzheimer, 55, 61 statistical method, 9–10 AMBER, 61, 65 Bending hinge, 64 2-Amino–2-imidazolidinone, 123, 125 Benzanilide, 256–257 Ammi visnaga, 254 Benzimidazolone, 256–257 b-Amyloid peptide (Ab), 62–63, 65 Benzocaine, 140 Amyotrophic lateral sclerosis (ALS), 90, 94, Benzodiazepines, 245 101 Benzopyrane, 127–128 Anionic channel blockers Benzopyrans, 61, 246–251, 261 mechanism of action of, 329–330 Benzothiadiazine 1,1-dioxide, 252–254 Antagonists, 59, 60 Benzothiadiazines, 253 Antiarrhythmic, 65–66, 68, 99, 101 Benzothiazepine, 70 Antiarrhythmic agents Benzothiazine derivatives, 251–252 class I, 245 Benzotriazole, 256–257 class II, 245 Bestrophins, 321, 322, 330, 331 class III, 245 Big potassium channels (BK channels), Antidepressant, 65–67 256, 257 Antiepileptic, 46 Bupivacaine, 56, 58, 59, 64, 69, 140 S.P.