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A Door to Drug Discovery

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A Door to Drug Discovery DrugDrug DiscoveriesDiscoveries && TherapeuticsTherapeutics ISSN 1881-7831 Online ISSN 1881-784X Volume 1, Number 1, July 2007 www.ddtjournal.com Shandong University China-Japan Cooperation Center for Drug Discovery & Screen International Advancement Center for Medicine & Health Research Drug Discoveries & Therapeutics Editor-in-Chief: Kazuhisa SEKIMIZU (The University of Tokyo, Tokyo, Japan) Associate Editor: Norihiro KOKUDO (The University of Tokyo, Tokyo, Japan) Drug Discoveries & Therapeutics is an international journal published by Shandong University China-Japan Cooperation Center for Drug Discovery & Screen (SDU-DDSC) and International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.). Drug Discoveries & Therapeutics mainly publishes articles related to basic and clinical pharmaceutical research such as pharmaceutical and therapeutical chemistry, pharmacology, pharmacy, pharmacokinetics, industrial pharmacy, pharmaceutical manufacturing, pharmaceutical technology, drug delivery, toxicology, and traditional herb medicine. Studies on drug-related fields such as biology, biochemistry, physiology, microbiology, and immunology are also within the scope of this journal. Subject Coverage: Basic and clinical pharmaceutical research including Pharmaceutical and therapeutical chemistry, Pharmacology, Pharmacy, Pharmacokinetics, Industrial pharmacy, Pharmaceutical manufacturing, Pharmaceutical technology, Drug delivery, Toxicology, and Traditional herb medicine. Langage: English Issues/Year: 12 Published by: IACMHR and SDU-DDSC ISSN: 1881-7831 (Online ISSN 1881-784X) Editorial and Head Office Wei TANG, MD PhD Secretary-in-General TSUIN-IKIZAKA 410 2-17-5 Hongo, Bunkyo-ku Tokyo 113-0033, Japan Tel: 03-5840-9697 Fax: 03-5840-9698 E-mail: [email protected] IACMHR CO., LTD. URL: http://www.ddtjournal.com http://www.ddtjournal.com i Drug Discoveries & Therapeutics Editorial Board Editor-in-Chief: Kazuhisa SEKIMIZU (The University of Tokyo, Tokyo, Japan) Associate Editor: Norihiro KOKUDO (The University of Tokyo, Tokyo, Japan) Secretary-in-General: Wei TANG (The University of Tokyo, Tokyo, Japan) Offi ce Manager: Munehiro NAKATA (Tokai University, Kanagawa, Japan) Web Editor: Yu CHEN (The University of Tokyo, Tokyo, Japan) English Editor: Curtis BENTLEY (Roswell, GA, USA) China Offi ce: Wenfang XU (Shandong University, Shandong, China) Editors: Yoshihiro ARAKAWA (Tokyo, Japan) Santad CHANPRAPAPH (Bangkok, Thailand) Fen Er CHEN (Shanghai, China) Guanhua DU (Beijing, China) Mohamed F. EL-MILIGI (Cairo, Egypt) Harald HAMACHER (Tuebingen, Germany) Hiroshi HAMAMOTO (Tokyo, Japan) Xiao-Jiang HAO (Yunnan, China) Langchong HE (Xi'an, China) Yongzhou HU (Hangzhou, China) Hans E. JUNGINGER (Phitsanulok, Thailand) Toshiaki KATADA (Tokyo, Japan) Ibrahim S. KHATTAB (Safat, Kuwait) Hiromichi KIMURA (Tokyo, Japan) Shiroh KISHIOKA (Wakayama, Japan) Kam Ming KO (Hong Kong, China) Nobuyuki KOBAYASHI (Nagasaki, Japan) Toshiro KONISHI (Tokyo, Japan) Masahiro KUROYANAGI (Hiroshima, Japan) Chun Guang LI (Victoria, Australia) Hongmin LIU (Zhengzhou, China) Ji-Kai LIU (Yunnan, China) Hongxiang LOU (Jinan, China) Ken-ichi MAFUNE (Tokyo, Japan) Norio MATSUKI (Tokyo, Japan) Tohru MIZUSHIMA (Kumamoto, Japan) Abdulla M. MOLOKHIA (Alexandria, Egypt) Masahiro MURAKAMI (Osaka, Japan) Yoshinobu NAKANISHI (Ishikawa, Japan) Yutaka ORIHARA (Tokyo, Japan) Xiao-Ming OU (Jackson, MS, USA) Wei-San PAN (Liaoning, China) Adel SAKR (Cincinnati, OH, USA) Abdel Aziz M. SALEH (Cairo, Egypt) Tomofumi SANTA (Tokyo, Japan) Yasufumi SAWADA (Tokyo, Japan) Hongbin SUN (Nanjing, China) Benny K. H. TAN (Singapore, Singapore) Ren-Xiang TAN (Nanjing, China) Murat TURKOGLU (Istanbul, Turkey) Stephen G. WARD (Bath, UK) Takako YOKOZAWA (Toyama, Japan) Liangren ZHANG (Beijing, China) Jian-Ping ZUO (Shanghai, China) ii http://www.ddtjournal.com CONTENTS Volume 1, Number 1, 2007 Editorial 1 Kazuhisa Sekimizu Editor-in-Chief News 2 China-Japan enhance joint research cooperation for drug discoveries and development: News from CJMWDDT 2007 in Jinan, China. Xin-Yong Liu, Xian-Jun Qu, Wei Tang 3 China’s new drug R&D is steadily advancing. Wen-Fang Xu Brief Report 4-8 Analysis on productivity of clinical studies across Asian countries a case comparison. Ken Takahashi, Shintaro Sengoku, Hiromichi Kimura 9-11 Lack of polymorphisms in the coding region of the highly conserved gene encoding transcription elongationfactor S-II (TCEA1). Takahiro Ito, Kent Doi, Naoko Matsumoto, Fumiko Kakihara, Eisei Noiri, Setsuo Hasegawa, Katsushi Tokunaga, Kazuhisa Sekimizu 12-13 GMP implementation in China: A double-edged sword for the pharmaceutical industry. Ruoyan Gai, Xian-Jun Qu, Hong-Xiang Lou, Jin-Xiang Han, Shu-Xiang Cui, Munehiro Nakata, Norihiro Kokudo, Yasuhiko Sugawara, Chushi Kuroiwa, Wei Tang Review 14-22 Viral infectious disease and natural products with antiviral activity. Kaio Kitazato, Yifei Wang, Nobuyuki Kobayashi 23-29 Target validation: A door to drug discovery. Xiu-Ping Chen, Guan-Hua Du 30-44 Therapeutic potential of heat-processed Panax ginseng with respect to oxidative tissue damage. Takako Yokozawa, Ki Sung Kang, Noriko Yamabe, Hyun Young Kim http://www.ddtjournal.com iii CONTENTS (Continued) Original Article 45-56 Anti-depressant and anti-nociceptive effects of 1,4-benzodiazepine-2- ones based cholecystokinin (CCK2) antagonists. Eric Lattmann, Jintana Sattayasai, Pornthip Lattmann, David C. Billington, Carl H. Schwalbe, Jordchai Boonprakob, Wanchai Airarat, Harjit Singh, Michael Offel, Alexander Staaf 57-60 ONIOM DFT/PM3 calculations on the interaction between dapivirine and HIV-1 reverse transcriptase, a theoretical study. Yong-Hong Liang, Fen-Er Chen 61-64 Studies on the development of rapidly disintegrating hyoscine butylbromide tablets. Ibrahim S Khattab, Abdel-Azim A Zaghloul, Mohsen I Afouna 65-72 Investigation of the binding behaviors of isonucleoside-incorporated oligonucleotides with complementary sequences. Zhu Guan, Hong-Wei Jin, Zhen-Jun Yang, Liang-Ren Zhang, Li-He Zhang 73-77 Modification of 15-akylidene andrographolide derivatives as alpha- glucosidase inhibitor. Hai-Wei Xu, Gai-Zhi Liu, Gui-Fu Dai, Chun-Li Wu, Hong-Min Liu 78-83 Evaluation of transdermal permeability of pentoxifylline gel: in vitro skin permeation and in vivo microdialysis using Wistar rats. Ke-Shu Yan, Ting-Xu Yan, Hong Guo, Ji-Zhong Li, Lan-Lan Wei, Chao Wang, Shu-Fang Nie, Wei-San Pan Guide for Authors Copyright iv http://www.ddtjournal.com Drug Discov Ther 2007;1(1):1. Editorial Editorial Kazuhisa Sekimizu, Ph.D. Professor, Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. n the 21st century, mankind is faced with the previously unseen reality of aging societies. I Developed countries have a strong social need for the development of advanced medical technology, including the establishment of treatment for diseases affecting the elderly, such as cancer and metabolic syndrome. Meanwhile, in other parts of the world, many people are struggling with war and poverty and face the threats of starvation and infection. Given this complex situation, the role played by technological development in the field of medicine is of great significance. In addition, the 21st century may belong to Asia, which has gained significant global recognition due to its rapid economic development. Accordingly, greater expectations have been placed on the role played by Asian researchers. However, research conducted in Asia has been criticized for its tendency to follow research conducted in Western countries. Therefore, development of original world-class research is urgently required in Asia. Journals provide researchers with valuable opportunities to present their research findings. With the cooperation of my close friends Dr. Wei Tang and Dr. Munehiro Nakata, I decided to participate in the launch of Drug Discovery and Therapeutics with the objective of contributing to the advancement of pharmaceutical research in Asia. This journal will cover not only laboratory science related to drug discovery, but also the broad field of social pharmacy. Submission of highly original articles that contribute to pharmaceutical sciences will be welcomed. I sincerely hope that Drug Discovery and Therapeutics will contribute to the field of pharmaceutical sciences as an esteemed journal for researchers in Asia and worldwide. July 21, 2007 Kazuhisa Sekimizu Editor-in-Chief Drug Discoveries & Therapeutics http://www.ddtjournal.com 1 News Drug Discov Ther 2007;1(1):2. China-Japan enhance joint research cooperation for drug discoveries and development: News from CJMWDDT 2007 in Jinan, China Xin-Yong Liu1, Xian-Jun Qu1, Wei Tang1, 2 iral hepatitis is currently a major global cause of Vmorbidity and mortality. In some Asian countries like China and Japan, Hepatitis B and C in particular are the most common extremely infectious diseases and are likely to develop into liver cirrhosis. Furthermore, statistics indicate that patients with liver cirrhosis resulting from hepatitis B and C have an increased risk of developing hepatocellular carcinoma (HCC). Scientists have worked tirelessly to find curative therapeutic strategies to control chronic hepatitis and liver cirrhosis, accompanied by improvements in public health and living conditions. China-Japan conference on new drug discoveries and China’s Shandong University and the University therapeutics (CJMWDDT), May 27-29, 2007, Jinan, China. of Tokyo in Japan previously established a long- term cooperative relationship.
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