bioRxiv preprint doi: https://doi.org/10.1101/2020.12.23.424241; this version posted April 16, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Genomic signature of shifts in selection and alkaline adaptation in highland fish 2 3 Chao Tong1,2, Miao Li3, Yongtao Tang1,4, Kai Zhao1,* 4 5 1 Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau 6 Biology, Chinese Academy of Sciences, Xining, 810001, China; 7 2 Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA; 8 3 Center for Advanced Retinal and Ocular Therapeutics, Scheie Eye Institute, University of 9 Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; 10 4 College of Fisheries, Henan Normal University, Xinxiang, 453007, China 11 12 * Corresponding author: 13 Chao Tong,
[email protected], https://orcid.org/0000-0001-5202-5507 14 Kai Zhao,
[email protected] 15 bioRxiv preprint doi: https://doi.org/10.1101/2020.12.23.424241; this version posted April 16, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 16 Abstract 17 Understanding how organisms adapt to aquatic life at high altitude is fundamental in 18 evolutionary biology.