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Biogerontology: a Novel Tool to Stay Healthy in Old Age
MoPAct Policy Brief: 5 Biogerontology: a novel tool to stay healthy in old age Policy priority Healthy lifestyle interventions in particular regarding nutrition and vaccination need to be implemented early in life with a lifecourse perspective. Summary: Key findings: • Accumulating evidence from experimental studies shows that aging is not inevitably linked with the development of chronic diseases. • Only 20-25% of healthy life expectancy (HLE) is predetermined by genes; lifestyle and environment play a major role. • Age-associated accumulation of molecular and cellular damage can be prevented or greatly delayed by lifestyle interventions e.g. dietary manipulations. • Classical strategies (e.g. nutrition, exercise, vaccination) require broad communication to public. • Novel strategies (e.g. dietary interventions, novel drugs, stem cells) need successful translation from the understanding of molecular mechanism to animal models to clinic. • To be successful interventions need to be started early Figure 1. Strategies to increase HLE. (1) Classical interventions include nutrition, exercise, vaccination, no smoking/alcohol/drugs. (2) Novel interventions include in life with a life-course perspective. dietary interventions, clearance of senescent and damaged cells, mitohormetics, stem cells, drugs against inflammation, rejuvenation factors from blood, telomeres, Background: epigenetic drugs, chaperons and proteolytic systems (novel interventions adapted from López-Otín et al., Cell 2013). Population aging is progressing fast in all developed countries. Aging is associated with the development of multiple serious chronic illnesses, including type 2 diabetes, hypertension, heart Prevention disease, stroke, cancer, cognitive impairment and increased Prevention prior to the development of age-associated diseases morbidity and mortality from infectious diseases. As people is key for successful aging. -
Chapter 6: Old People Are People Too, So Let's Act
Career Planning & Adult Development JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Helen Harkness, Guest Editor QThe Future Q The End of Work as We Know It QJobs and Careers on the Front Line of the Future QSilicon Valley and the New Rules of Work Q Training Challenges Facing Education and Training and Career Development in the Future QOld people are people too, so let’s act accordingly Q Crisis of Human Capital in Aerospace: It’s All About the STEM QCollege for All – Reality or Flawed Myth? QOur Jobs: The American Workforce and Economy in Crisis Q The Future Has Arrived: The Future is Now the Present Summer 2015..............................Career Planning and Adult Development JOURNAL..............................1 CAREER PLANNING and ADULT DEVELOPMENT JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Looking Ahead with the Journal,E\Steven E. Beasley, Managing Editor4 Introduction to this Issue, E\ Helen Harkness, PhD, Guest Editor5 Chapter 1: 7KH)XWXUHE\ Leigh Ellen Key8 Chapter 2: 7KH(QGRI:RUNDV:H.QRZ,Wby Andy Hines10 Chapter 3: -REVDQG&DUHHUVRQWKH)URQW/LQHRIWKH)XWXUHby Gary Marx20 Chapter 4: 6LOLFRQ9DOOH\DQGWKH1HZ5XOHVRI:RUNE\Gary A. Bolles28 Chapter 5: 7UDLQLQJ&KDOOHQJHV)DFLQJ(GXFDWLRQDQG7UDLQLQJ DQG&DUHHU'HYHORSPHQWLQWKH)XWXUHE\Timothy C. Mack40 Chapter 6: 2OGSHRSOHDUHSHRSOHWRRVROHW·VDFWDFFRUGLQJO\by Aubrey de Grey47 Chapter 7: &ULVLVRI+XPDQ&DSLWDOLQ$HURVSDFH,W·V$OO$ERXWWKH67(0 by Deborah Westphal51 Chapter 8: &ROOHJHIRU$OO²5HDOLW\RU)ODZHG0\WK"E\ -
Mixing Old and Young: Enhancing Rejuvenation and Accelerating Aging
Mixing old and young: enhancing rejuvenation and accelerating aging Ashley Lau, … , James L. Kirkland, Stefan G. Tullius J Clin Invest. 2019;129(1):4-11. https://doi.org/10.1172/JCI123946. Review Donor age and recipient age are factors that influence transplantation outcomes. Aside from age-associated differences in intrinsic graft function and alloimmune responses, the ability of young and old cells to exert either rejuvenating or aging effects extrinsically may also apply to the transplantation of hematopoietic stem cells or solid organ transplants. While the potential for rejuvenation mediated by the transfer of youthful cells is currently being explored for therapeutic applications, aspects that relate to accelerating aging are no less clinically significant. Those effects may be particularly relevant in transplantation with an age discrepancy between donor and recipient. Here, we review recent advances in understanding the mechanisms by which young and old cells modify their environments to promote rejuvenation- or aging-associated phenotypes. We discuss their relevance to clinical transplantation and highlight potential opportunities for therapeutic intervention. Find the latest version: https://jci.me/123946/pdf REVIEW The Journal of Clinical Investigation Mixing old and young: enhancing rejuvenation and accelerating aging Ashley Lau,1 Brian K. Kennedy,2,3,4,5 James L. Kirkland,6 and Stefan G. Tullius1 1Division of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3Singapore Institute for Clinical Sciences, Singapore. 4Agency for Science, Technology and Research (A*STAR), Singapore. -
Vascular Tissue Challenge Official Rules Updated 2019-08-14
Vascular Tissue Challenge Official Rules Updated 2019-08-14 SECTION 1: Executive Summary 2 SECTION 2: Definitions & Assumptions 3 SECTION 3: Evaluation Criteria 3 SECTION 4: Safety & Care 5 SECTION 5: Registration Requirements 5 SECTION 6: Judging 6 SECTION 7: Timeline 8 SECTION 8: Eligibility, Disqualification, & Appeal 9 SECTION 9: Awards 10 The Methuselah Foundation Vascular Tissue Challenge Rules Page 1 SECTION 1: EXECUTIVE SUMMARY Objectives Summary The Vascular Tissue Challenge (hereafter “Challenge”) is a $500,000 prize purse to be divided among the first three teams who can successfully create thick, human vascularized organ tissue in an in-vitro environment while maintaining metabolic functionality similar to their in vivo native cells throughout a 30 calendar day survival period. NASA’s objective for this Challenge is to produce technologies capable of creating viable thick (>1cm) metabolic tissues that can be used to advance research on human physiology, fundamental space biology, and medicine taking place both on the Earth and the ISS National Laboratory. Specifically, technology innovations may enable the growth of de novo tissues and organs on orbit which may address the risks related to traumatic bodily injury, improve general crew health, and enhance crew performance on future, long-duration missions. Evaluation Criteria Summary Produce an in vitro vascularized tissue that is > 1 centimeter in thickness in all dimensions at the launch of the trial and maintains >85% survival of the required parenchymal cells throughout a 30 calendar day period. Tissues must provide adequate blood perfusion without uncontrolled leakage into the bulk tissue to maintain metabolic functionality similar to their in vivo native cells. -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
Great Mambo Chicken and the Transhuman Condition
Tf Freewheel simply a tour « // o é Z oon" ‘ , c AUS Figas - 3 8 tion = ~ Conds : 8O man | S. | —§R Transhu : QO the Great Mambo Chicken and the Transhuman Condition Science Slightly Over the Edge ED REGIS A VV Addison-Wesley Publishing Company, Inc. - Reading, Massachusetts Menlo Park, California New York Don Mills, Ontario Wokingham, England Amsterdam Bonn Sydney Singapore Tokyo Madrid San Juan Paris Seoul Milan Mexico City Taipei Acknowledgmentof permissions granted to reprint previously published material appears on page 301. Manyofthe designations used by manufacturers andsellers to distinguish their products are claimed as trademarks. Where those designations appear in this book and Addison-Wesley was aware of a trademark claim, the designations have been printed in initial capital letters (e.g., Silly Putty). .Library of Congress Cataloging-in-Publication Data Regis, Edward, 1944— Great mambo chicken and the transhuman condition : science slightly over the edge / Ed Regis. p- cm. Includes bibliographical references. ISBN 0-201-09258-1 ISBN 0-201-56751-2 (pbk.) 1. Science—Miscellanea. 2. Engineering—Miscellanea. 3. Forecasting—Miscellanea. I. Title. Q173.R44 1990 500—dc20 90-382 CIP Copyright © 1990 by Ed Regis All rights reserved. No part ofthis publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Printed in the United States of America. Text design by Joyce C. Weston Set in 11-point Galliard by DEKR Corporation, Woburn, MA - 12345678 9-MW-9594939291 Second printing, October 1990 First paperback printing, August 1991 For William Patrick Contents The Mania.. -
Shared Ageing Research Models (Sharm): a New Facility to Support Ageing Research
Biogerontology (2013) 14:789–794 DOI 10.1007/s10522-013-9457-0 METHOD Shared Ageing Research Models (ShARM): a new facility to support ageing research Adele L. Duran • Paul Potter • Sara Wells • Tom Kirkwood • Thomas von Zglinicki • Anne McArdle • Cheryl Scudamore • Qing-Jun Meng • Gerald de Haan • Anne Corcoran • Ilaria Bellantuono Received: 5 July 2013 / Accepted: 16 August 2013 / Published online: 2 October 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com Abstract In order to manage the rise in life expec- Wellcome Trust, open to all investigators. It collects, tancy and the concomitant increased occurrence of stores and distributes flash frozen tissues from aged age-related diseases, research into ageing has become murine models through its biorepository and provides a strategic priority. Mouse models are commonly a database of live ageing mouse colonies available in utilised as they share high homology with humans and the UK and abroad. It also has an online environment show many similar signs and diseases of ageing. (MICEspace) for collation and analysis of data from However, the time and cost needed to rear aged communal models and discussion boards on subjects cohorts can limit research opportunities. Sharing of such as the welfare of ageing animals and common resources can provide an ethically and economically endpoints for intervention studies. Since launching in superior framework to overcome some of these issues July 2012, thanks to the generosity of researchers in but requires dedicated infrastructure. Shared Ageing UK and Europe, ShARM has collected more than Research Models (ShARM) (www.ShARMUK.org) 2,500 tissues and has in excess of 2,000 mice regis- is a new, not-for-profit organisation funded by tered in live ageing colonies. -
5 EVENTS in ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland
FIFTH ANNUAL - LIFE SCIENCE R&D DATA INTELLIGENCE LEADERS FORUM Basel, Switzerland January 23-24th, 2018 Optional Workshop 22nd, January Hear keynote presentations from the experts: Etzard Stolte Global Head Knowledge Management Roche, Switzerland Abhimanyu Verma 5 EVENTS IN ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland Day 1: Torsten Niederdraenk Head of Technology Center Strategic Developments in R&D Big Siemens Healthcare, Germany Data Catherine Brownstein Scientific Director Day 2 (am): Stream 1 Manton Center for Orphan Disease Research Boston Children’s Hospital, USA Discovery & Omics Data Excellence Navin Ramachandran Radiology Consultant Day 2 (am): Stream 2 University College London Hospitals NHS Foundation Trust, Healthcare specialist in distributed ledgers and IoT Clinical & Patient Level Data IOTA Foundation, UK Excellence Marie-Claire Peakman Executive Director, Head Hit Discovery & Lead Profiling, Medicine Design Day 2 (pm): Stream A Pfizer, USA R&D IT & Bioinformatics Alex Zhavoronkov Co-founder, Insilico Medicine, CSO Day 2 (pm): Stream B The Biogerontology Research Foundation, UK Ivana Schnur Digital Health Collaborations Co-founder, CMO Sense.ly, USA Pre-Event Workshop: Jan 22nd Paul Wicks Artificial Intelligence for Drug Vice President of Innovation PatientsLikeMe, UK Discovery: Workshop for Senior Jazz Panchoo Global Strategy Head, VP, Digital Platforms Executives Ascensia Diabetes Care, Switzerland This Event is Certified for Continuing Professional Development with more than 30 presentations -
Scott Douglas Jacobsen In-Sight: Independent Interview-Based Journal Interviews 01/14/2017
SCOTT DOUGLAS JACOBSEN IN-SIGHT: INDEPENDENT INTERVIEW-BASED JOURNAL INTERVIEWS 01/14/2017 An Interview with Lawrence Hill (Part Two) on January 8, 2017 An interview with Lawrence Hill. He discusses: the motivation for compassionate truth; religious or secular worldview influencing it; long time to write novels and this as either part of habit or personality; view on books in terms of their personal importance; strengths and weaknesses of the writing style; reason for writing more non-fiction than fiction; importance of nearly dying; importance of Malcolm X as an influence on him; influence of Martin Luther King on him; meaning of blood to him; and the dangers of associating blood with race or religion. Keywords: author, blood, Lawrence Hill, Malcolm X, Martin Luther King, novelist, race, religion, writer. An Interview with Lawrence Hill (Part One) on January 1, 2017 An interview with Lawrence Hill. He discusses: geographic, cultural, and linguistic family background; familial influence on development; parents’ love story; influence on parents’ relationship on him; influences and pivotal moments in major cross-sections of life; being read to each night by his mother; journalistic experience influencing writing to date; self-editing for writers; number of drafts; singer- songwriter brother, Dan Hill, influence on professional work; recommended songs for listening pleasure by Dan; affect of Karen Hill’s mental illness and death on him; advice for coping with the emotional pain; Café Babanussa (2016) and an essay inside called On Being Crazy; and Karen’s written work and impact on him. Keywords: author, Canadian, Dan Hill, Karen Hill, Lawrence Hill, novelist, writer. -
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Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Graphical abstract Authors Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, ..., Marco Demaria, Arvind Ramanathan, Judith Campisi Correspondence [email protected] (C.D.W.), [email protected] (A.R.), [email protected] (J.C.) In brief Senolytics, transgenic, and pharmacological interventions that selectively kill senescent cells are currently in clinical trials aiming to treat age-related degenerative pathologies. Here, Wiley et al. discover that senescent cells produce multiple signaling lipids known as oxylipins. One oxylipin, dihomo-15d-PGJ2, promotes features of senescence by activating RAS and is released from cells during senolysis, serving as the first biomarker of the Highlights process in culture and in vivo. d Senescent cells make several oxylipins, dihomo- prostaglandins, and leukotrienes d Dihomo-15d-PGJ2 is intracellular during senescence and released during senolysis d Dihomo-15d-PGJ2 activates RAS, promoting senescence and the SASP d Positive feedback between prostaglandins, RAS, and p53 maintains senescence Wiley et al., 2021, Cell Metabolism 33, 1–13 June 1, 2021 ª 2021 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2021.03.008 ll Please cite this article in press as: Wiley et al., Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis, Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.03.008 ll Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Christopher D. Wiley,1,2,* Rishi Sharma,1 Sonnet S. Davis,1 Jose Alberto Lopez-Dominguez,1 Kylie P. Mitchell,1 Samantha Wiley,1 Fatouma Alimirah,1 Dong Eun Kim,1 Therese Payne,1 Andrew Rosko,1 Eliezer Aimontche,1 Sharvari M. -
Read Our New Annual Report
The seeds of a concept. The roots of an idea. The potential of a world free of age-related disease. Photo: Sherry Loeser Photography SENS Research Foundation Board of Directors Barbara Logan, Chair Bill Liao, Secretary Kevin Perrott, Treasurer Michael Boocher Jonathan Cain Kevin Dewalt Michael Kope Jim O’Neill Frank Schüler Sherry Loeser Photography 2 Contents CEO Letter (Jim O’Neill) 4 Finances 5 Donors 6 - 7 Fundraising & Conferences 8 - 9 Around the World with Aubrey de Grey 10 Outreach 11 Founding CEO Tribute & Underdog Pharmaceuticals 12 - 13 Investments 14 Welcome New Team Members 15 Education 16 - 17 Publications & Research Advisory Board 18 Research Summaries 19 - 22 Ways to Donate 23 The SRF Team Front row: Anne Corwin (Engineer/Editor), Amutha Boominathan (MitoSENS Group Lead), Alexandra Stolzing (VP of Research), Aubrey de Grey (Chief Science Officer), Jim O’Neill (CEO), Bhavna Dixit (Research Associate). Center row: Caitlin Lewis (Research Associate), Lisa Fabiny-Kiser (VP of Operations), Gary Abramson (Graphics), Maria Entraigues-Abramson (Global Outreach Coordinator), Jessica Lubke (Administrative Assistant). Back row: Tesfahun Dessale Admasu (Research Fellow), Amit Sharma (ImmunoSENS Group Lead), Michael Rae (Science Writer), Kelly Protzman (Executive Assistant). Not Pictured: Greg Chin (Director, SRF Education), Ben Zealley (Website/Research Assistant/ Deputy Editor) Photo: Sherry Loeser Photography, 2019 3 From the CEO At our 2013 conference at Queens College, Cambridge, I closed my talk by saying, “We should not rest until we make aging an absurdity.” We are now in a very different place. After a lot of patient explanation, publication of scientific results, conferences, and time, our community persuaded enough scientists of the feasibility of the damage repair approach to move SENS and SENS Research Foundation from the fringes of scientific respectability to the vanguard of a mainstream community of scientists developing medical therapies to tackle human aging.