Table S8. Ontology category membership for up-regulated in Arctic charr (Salvelinus alpinus) family 12 gill tissue.

GO ID GO category description FDR P-value Genes within GO category

51301 cell division 1.04E-13 CKS1B, HAUS5, NEK1, AURKA, CEP55, CCNE2, KIF2C, SPC25, TOP1, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, HELLS, STAG2, ERCC6L, CDK1, KIF11, CKAP5, CCNF, NUF2, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, CDK4, SMC2, NCAPD2, CCNB1, MAD2L1, CCND2, CKS2, KIF20B, BUB1B, SETD8, MIS18BP1, SEPT6

279 M phase 1.54E-13 HAUS5, NEK1, AURKA, CEP55, RPA1, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, HELLS, STAG2, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, TPX2, CASC5, MND1, CENPE, UBE2I, CDC20, BIRC5, TACC3, SMC2, ATM, NCAPD2, CCNB1, MAD2L1, CKS2, KIF20B, BUB1B, SETD8, MIS18BP1, KPNA2

87 M phase of mitotic 1.54E-13 HAUS5, NEK1, AURKA, CEP55, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, STAG2, HELLS, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, SMC2, NCAPD2, CCNB1, MAD2L1, KIF20B, BUB1B, SETD8, MIS18BP1

280 nuclear division 1.54E-13 HAUS5, NEK1, AURKA, CEP55, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, STAG2, HELLS, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, SMC2, NCAPD2, CCNB1, MAD2L1, BUB1B, SETD8, MIS18BP1

7067 mitosis 1.54E-13 HAUS5, NEK1, AURKA, CEP55, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, STAG2, HELLS, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, SMC2, NCAPD2, CCNB1, MAD2L1, BUB1B, SETD8, MIS18BP1

48285 organelle fission 5.03E-13 HAUS5, NEK1, AURKA, CEP55, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, STAG2, HELLS, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, SMC2, NCAPD2, CCNB1, MAD2L1, BUB1B, SETD8, MIS18BP1

22403 cell cycle phase 3.41E-12 HAUS5, NEK1, AURKA, CEP55, RPA1, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, HELLS, STAG2, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, PIM1, TPX2, CASC5, MND1, CENPE, UBE2I, CDC20, BIRC5, CDK4, TACC3, SMC2, ATM, SLBP, NCAPD2, CCNB1, MAD2L1, CKS2, KIF20B, BUB1B, SETD8, MIS18BP1, KPNA2

278 mitotic cell cycle 1.53E-09 HAUS5, NEK1, AURKA, CEP55, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, CCNA2, STAG2, HELLS, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, PIM1, TPX2, CASC5, CENPE, UBE2I, CDC20, BIRC5, CDK4, SMC2, NCAPD2, CCNB1, MAD2L1, PSME1, KIF20B, BUB1B, SETD8, MIS18BP1, KPNA2

7049 cell cycle 8.86E-09 LZTS1, E2F8, AURKA, KIF2C, CDCA8, CDC45, RAD21, CCNA2, STAG2, CDK1, KIF11, CHTF8, CCNF, KIF15, TPX2, PIM1, MND1, UBE2I, TACC3, CDK4, NCAPD2, MAD2L1, PSME1, BUB1B, SEPT6, KPNA2, CKS1B, HAUS5, TICRR, LIN9, NEK1, CEP55, RPA1, SPC25, NCAPH, NCAPG, NCAPG2, CEBPZ, BUB1, SKA3, ZWILCH, HELLS, ERCC6L, CKAP5, NASP, NUF2, CASC5, CENPE, GO ID GO category description FDR P-value Genes within GO category BIRC5, CDC20, SMC2, GSG2, ATM, SLBP, CCNB1, MAPK13, CKS2, KIF20B, SETD8, MIS18BP1

22402 cell cycle process 1.66E-08 HAUS5, NEK1, AURKA, CEP55, RPA1, KIF2C, SPC25, CDCA8, NCAPH, RAD21, NCAPG2, NCAPG, CEBPZ, BUB1, SKA3, ZWILCH, CCNA2, HELLS, STAG2, ERCC6L, CDK1, KIF11, CKAP5, KIF15, CCNF, NUF2, PIM1, TPX2, CASC5, MND1, CENPE, UBE2I, CDC20, BIRC5, CDK4, TACC3, SMC2, ATM, SLBP, NCAPD2, CCNB1, MAD2L1, PSME1, CKS2, KIF20B, BUB1B, SETD8, MIS18BP1, KPNA2

7059 segregation 8.90E-06 NUF2, CASC5, CENPE, UBE2I, BIRC5, CTCF, SMC2, NCAPD2, CCNB1, SPC25, NCAPH, RAD21, NCAPG, SKA3, STAG2

75 cell cycle checkpoint 1.26E-04 BACH1, CDK1, TICRR, CASC5, CENPE, BIRC5, ATM, CCNE2, CCNB1, CDC45, MAD2L1, BUB1, BUB1B, ZWILCH, CCNA2

51726 regulation of cell cycle 2.28E-04 BACH1, CKS1B, TICRR, CTCF, BOP1, CDC37, CCNE2, CASP3, AHRR, CDC45, CEBPZ, BUB1, ZWILCH, CCNA2, STAG2, CDK1, CCNF, PIM1, TPX2, CASC5, CENPE, BIRC5, CDK4, TACC3, ATM, SLBP, CCNB1, MAD2L1, HDAC1, CCND2, CKS2, KIF20B, BUB1B

17085 response to insecticide 3.78E-04 CCNB1, TYMS, AHRR, RFC3

51983 regulation of chromosome segregation 6.88E-04 CCNB1, KIF2C, BUB1, CENPE, CTCF

7093 mitotic cell cycle checkpoint 7.62E-04 CCNB1, CDK1, MAD2L1, TICRR, BUB1, BUB1B, CENPE, ZWILCH, CCNA2, ATM

6996 organelle organization 9.46E-04 XRCC5, EIF6, FOXA3, EZH2, AURKA, CTCF, CBX5, ARHGAP4, EPC1, KIF2C, CASP3, CDCA8, RAD21, CASP7, SOX15, CCNA2, STAG2, H1F0, CDK1, KIF11, KIF15, CCNF, TPX2, PIM1, UBE2I, HLTF, TACC3, NCAPD2, BAZ1A, MAD2L1, BUB1B, CLN8, LCP1, KIF4A, HAUS5, DIAPH1, NEK1, DIAPH3, ABI2, CEP55, RPA1, SPC25, NCAPH, DOCK2, KRAS, NCAPG2, NCAPG, BUB1, SKA3, ZWILCH, HELLS, ERCC6L, CKAP5, NASP, WDR5, NUF2, CASC5, CENPE, CDC20, BIRC5, SMC2, GSG2, CCNB1, HDAC1, CKS2, SETD8, MIS18BP1

31577 spindle checkpoint 9.92E-04 CCNB1, BUB1, CASC5, CENPE, BIRC5, ATM

2376 immune system process 3.35E-03 XRCC5, IFI30, ITGB2, ITGB1, HSH2D, GCH1, MBP, RPA1, CASP3, TMEM173, DOCK2, MYD88, SLK, XBP1, TAP1, CASP8, RTKN2, ERAP1, IMPDH1, HELLS, EGR1, FYB, CEBPB, NCF2, NUB1, MYO1E, CD40, TACC3, VAV1, ANXA3, ATM, ILF2, PLCG2, IRF1, BANK1, SEMA4D, LCP1

6323 DNA packaging 6.54E-03 H1F0, CDK1, NCAPH, NCAPG, NCAPG2, CTCF, SMC2, HELLS, NCAPD2

30261 chromosome condensation 9.00E-03 CDK1, NCAPH, NCAPG, NCAPG2, SMC2, NCAPD2

46649 lymphocyte activation 9.89E-03 EGR1, CD40, ITGB1, VAV1, ATM, HSH2D, DOCK2, SLK, PLCG2, IRF1, BANK1, IMPDH1, HELLS, LCP1

7051 spindle organization 1.03E-02 SPC25, HAUS5, KIF11, CKAP5, CKS2, BUB1B, AURKA, TACC3

6950 response to stress 1.03E-02 BACH1, XRCC5, HSP90AB1, FOXA3, PASK, TP63, IL17RB, MBP, CASP3, TMEM173, MYD88, RAD21, SLK, NSMCE1, CASP8, SOX15, CCNA2, CDK1, NCF2, PIM1, GTF2H3, GRHL3, CD40, TACC3, STRA13, RFC3, RFC4, EIF2S1, ABAT, CLN8, DCBLD2, NMI, ASS1, TICRR, EGLN1, ITGB2, CDH3, ITGB1, GCH1, RPA1, TYMS, AHRR, TAP1, CEBPZ, MYOF, TCIRG1, CEBPB, NOS1, SLC12A2, GO ID GO category description FDR P-value Genes within GO category NUB1, NOX1, EPHX2, ITGA2, OXSR1, STAT1, ANXA3, ATM, CCNB1, LSP1, P2RX4, MAPK13, PCNA, PLA2G4C, PARP2, PRKRIR

6259 DNA metabolic process 1.45E-02 BACH1, XRCC5, TICRR, LIN9, CTCF, RPA1, CCNE2, TYMS, TOP1, CASP3, CDC45, RAD21, SLK, NSMCE1, HELLS, NASP, CHTF8, GINS4, PIM1, GTF2H3, MND1, ATM, SLBP, STRA13, RFC3, RFC4, RRM2, RRM1, PCNA, KPNA2, PARP2

8283 cell proliferation 1.45E-02 XRCC5, CKS1B, OSMR, TP63, BOP1, KIF2C, STAT4, AHRR, DOCK2, SLK, IMPDH1, HELLS, CSF1R, CEBPB, NASP, KIF15, TPX2, PIM1, ITGA2, CD40, TACC3, WNT7B, CKS2, PCNA, BUB1B

50896 response to stimulus 1.52E-02 XRCC5, ZC3HAV1, OSMR, PASK, AURKA, AQP3, IL17RB, TOP1, MYD88, RAD21, ERAP1, CCNA2, NCF2, PIM1, GRHL3, CD40, CYP1A2, TACC3, STRA13, RFC3, RFC4, ARRB2, EIF2S1, ABAT, DCBLD2, CYP1B1, ASS1, TICRR, ITGB2, ITGB1, AHRR, DOCK2, KRAS, EPHX2, ITGA2, OXSR1, VAV1, ATM, GART, P2RX4, PLCG2, PCNA, PLA2G4C, PARP2, PRKRIR, BACH1, HSP90AB1, GM2A, FOXA3, TP63, DEK, MBP, TMEM173, CASP3, SLK, NSMCE1, CASP7, CASP8, SOX15, IMPDH1, EGR1, CDK1, GTF2H3, CFTR, CDK4, CCND2, MGEA5, SEMA4D, CLN8, SEMA4A, LCP1, NMI, ABI2, EGLN1, CDH3, GCGR, GCH1, RPA1, TYMS, XBP1, TAP1, CEBPZ, MYOF, FYB, TCIRG1, NOS1, CEBPB, NUB1, SLC12A2, NOX1, ATP1A1, STAT1, ANXA3, CCNB1, LSP1, WNT7B, ILF2, MAPK13

71103 DNA conformation change 1.52E-02 H1F0, CDK1, TOP1, NCAPH, NCAPG, NCAPG2, CTCF, SMC2, HELLS, NCAPD2

45321 leukocyte activation 1.96E-02 EGR1, CD40, ITGB1, VAV1, ANXA3, ATM, HSH2D, DOCK2, SLK, PLCG2, IRF1, BANK1, IMPDH1, HELLS, LCP1

6260 DNA replication 2.94E-02 TICRR, LIN9, NASP, CHTF8, GINS4, SLBP, RPA1, CCNE2, TYMS, TOP1, CDC45, RFC3, RFC4, RRM2, RRM1, PCNA

50794 regulation of cellular process 3.48E-02 XRCC5, EFNA1, OSMR, PASK, SYNCRIP, AURKA, AQP3, CBX5, IL17RB, BATF, EPC1, G2E3, CDCA7, MYD88, RAD21, RRAS, ERAS, PUM2, CCNA2, STAG2, NET1, GOLT1B, PIM1, GRHL3, CD40, TACC3, STRA13, RFC4, NME3, BAZ1A, MAD2L1, ARRB2, ABT1, BACE2, EIF2S1, RIPK3, PRDM1, DCBLD2, PLXNC1, TICRR, IFI30, ITGB2, BOP1, CDC37, FOXQ1, AHRR, MOV10, KRAS, CERS2, RTKN2, SKA3, FGL1, TRAF5, HELLS, ARHGDIA, CSF1R, TESC, MAFB, WDR5, ITGA2, CASC5, CDC20, OXSR1, VAV1, FOXP1, EPHA2, ATM, P2RX4, HDAC1, PLCG2, PCNA, PTPN1, TMPO, PRKRIR, HSP90AB1, BACH1, LZTS1, FOXA3, E2F8, EZH2, TP63, CTCF, DEK, RHOV, MBP, SLA, CANT1, ARHGAP4, LSM14A, CCNE2, KIF2C, BNIPL, CASP3, CDC45, SLK, CASP8, DLG3, SOX15, LRRFIP1, MYB, EGR1, CDK1, CCDC88C, LDB1, CCNF, PKN2, TPX2, GTF2H3, UBE2I, HLTF, CDK4, ECT2, SENP1, PSME1, CCND2, RAB5A, MGEA5, BUB1B, SEMA4D, KPNA2, CLN8, LCP1, FAIM2, RIN3, CKS1B, TNFRSF21, NMI, FKBP4, CYTH4, ABI3, EGLN1, TPM2, GCGR, ITM2C, TRIB2, RPA1, ZFP36L1, DGKA, TYMS, STAT4, XBP1, RASGRP2, SHISA5, TAP1, CEBPZ, BUB1, ZWILCH, TCIRG1, FYB, CEBPB, NOS1, PDK3, NOX1, CENPE, DGKH, ATP1A1, BIRC5, STAT1, GSG2, ANXA3, SLBP, CCNB1, CASP10, WNT7B, RASSF5, ILF2, MAPK13, IRF1, CKS2, KIF20B, DSC1, SETD8, PERP, DUSP7, FOXE3

1775 cell activation 3.66E-02 EGR1, CD40, ITGB1, VAV1, ANXA3, ATM, HSH2D, P2RX4, DOCK2, SLK, PLCG2, IRF1, BANK1, IMPDH1, LCP1, HELLS

9404 toxin metabolic process 3.94E-02 AHRR, CYP1B1, CYP1A2 GO ID GO category description FDR P-value Genes within GO category

71174 mitotic cell cycle spindle checkpoint 4.14E-02 CCNB1, BUB1, CENPE, ATM

6261 DNA-dependent DNA replication 4.73E-02 RPA1, CCNE2, TOP1, CDC45, RFC3, RFC4, PCNA, SLBP