Snapshot: Lipid Kinase and Phosphatase Reaction Pathways Simon A

376 Cell SnapShot: Lipid Kinase and Phosphatase

aur 6 04©04Esve n. DOI http://dx.doi.org/10.1016/j.cell.2014.01.003 156, January 16,2014©2014 ElsevierInc. Reaction Pathways Simon A. Rudge and Michael J.O. Wakelam The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK

PIK3CA, PIK3CB, PIK3CD, MTM1, MTMR1, MTMR2, PIP4K2A, PIP4K2B, PIK3CG, IPMK, PIK3C2A, MTMR3, MTMR6, MTMR8, PIK3C2B MTMR14, PTEN, TPTE2 PIP4K2C

TMEM55A, TMEM55B PTEN, TPTE2

PI(3,5)P2 PI(5)P PI(4,5)P2 PI(3,4,5)P3

TPTE2, FIG4, OCRL, PIKFYVE TPTE2, FIG4, OCRL, FIG4 PIKFYVE PIP5K1A INPP5B, INPP5D, PIP5K1A INPP5B, INPP5D, PIP5K1A PIP5K1A PTPMT1 INPP5E, INPP5F, PIP5K1B PIP5K1B INPP5E PIP5K1B INPP5E, INPP5F, PIP5K1B PIP5K1C INPP5J, INPP5K, PIP5K1C INPP5J, INPP5K, INPPL1 PIP5K1C INPPL1, SYNJ1, SYNJ2

PIK3C3, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3C2A, PIK3C2B, PIK3CD, PIK3CG PI4K2A, PI4K2B, PIK3C2G, PIK3CA, PI4KA, PI4KB PIK3CB, PIK3CD, PIK3CG PIP4K2A PIP5K1A PIP5K1B PIP5K1C MTM1, MTMR1, MTMR2, SACM1L, SYNJ1 PTEN, TPTE2 PI(3)P MTMR3, MTMR4, MTMR6, PI PI(4)P PI(3,4)P MTMR7, MTMR8, MTMR14, 2 PTEN, TPTE2, SACM1L, SYNJ1 PIP4K2B

See online version for legend and references. INPP4A, INPP4B AGK

PPAP2A, PPAP2B, PPAP2C

SPHK1, SPHK2 CERK MAG LPA

DGKA, DGKB, DGKG, DGKD, DGKE, DGKZ, DGKH, DGKQ, SGPP1, PPAP2A, PPAP2A, PPAP2B, DGKI, DGKK, EIF2AK3, AGK PPAP2B, PPAP2C PPAP2C

Sphingosine Sphingosine 1-P Ceramide Ceramide 1-P PPAP2A, PPAP2B, PPAP2C, DAG PPAPDC1A, PPAPDC1B, PA PPAPDC2, LPIN1, LPIN2, LPIN3 SnapShot: Lipid Kinase and Phosphatase Reaction Pathways Simon A. Rudge and Michael J.O. Wakelam The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK

This SnapShot presents the reaction pathways catalyzed by the known mammalian enzymes—listed in the SnapShot “Lipid Kinases and Phosphatases” (Cell 155, December 19, 2013)—that either phosphorylate or dephosphorylate lipids.

In cases in which only in vitro data have been reported, the gene encoding the enzyme is shown in italics and/or a dashed line is used to represent the reaction catalyzed.

The lipid fatty acid moieties depicted in the reaction pathways in this SnapShot have been purposely simplified, and therefore they do not represent the complexity of what occurs naturally, i.e., fatty acids can vary in both length and saturation, in particular, the polyphosphoinositides generally have a polyunsaturated fatty acid moiety at the sn-2 position.

ABBREVIATIONS

PI, phosphatidylinositol; PI(3)P, phosphatidylinositol 3-phosphate; PI(4)P, phosphatidylinositol 4-phosphate; PI(5)P, phosphatidylinositol 5-phosphate; PI(3,4)P2, phosphatidylinositol

3,4-bisphosphate; PI(3,5)P2, phosphatidylinositol 3,5-bisphosphate; PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate; PI(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate; PA, phosphatidic acid; LPA, lysophosphatidic acid; DAG, diacylglycerol; MAG, monoacylglycerol.

Acknowledgments

Work in the S.A.R. and M.J.O.W. lab is supported by the Biotechnology and Biological Sciences Research Council.