CURRICULUM VITAE

Paul R. Carney, MD

Contact Child Health Department Office: 573-882-6882 University of Missouri – Columbia Mobile: 352-262-6509 400 North Keene street Fax: 573-884-5179 Columbia, Missouri 65201 Email: [email protected]

Education 03/30/83 to 12/19/90 M.D., with Distinction, Medicine, University of Valparaiso School of Medicine 09/01/79 to 05/25/83 B.S., Chemistry (Honors), John Carroll University, University Heights Cleveland, Ohio Postgraduate Training 07/01/96 to 06/30/98 Fellowship in Epilepsy, Clinical Neurophysiology, and, Sleep Disorders, University of Michigan Hospital, Ann Arbor, Michigan 07/01/94 to 06/30/97 Fellowship in Pediatric Neurology, University of Michigan, Ann Arbor, Michigan 07/01/92 to 06/30/94 Internship, Case Western Reserve University, University Hospitals of Cleveland, Rainbow Babies and Children’s Hospital Academic Positions 10/19/20 to present Professor, Department of Child Health, University of Missouri at Columbia Missouri 06/30/16 to 06/15/20 Professor, Department of Neurology University of North Carolina at Chapel Hill 06/30/16 to 06/15/20 Joint Professor, Department of Pediatrics, University of North Carolina at Chapel Hill 06/30/16 to 06/15/20 In patient Pediatric Neurologist Ward Consultant, 4 months/year 06/30/16 to 06/15/20 Outpatient Pediatric Neurologist, 2 half days per week 06/30/16 to 06/15/20 Pediatric Epileptologist/Clinical Neurophysiologist, 4 months/year 09/01/16 to 65/15/20 Graduate Faculty, Biological and Biomedical Sciences Program University of North Carolina at Chapel Hill

09/01/16 to 06/15/20 Member, Neuroscience Program, University of North Carolina 10/01/16 to 06/15/20 Member, Carolina Institute for Developmental Disabilities University of North Carolina at Chapel Hill 09/01/02 to 06/30/17 Graduate Faculty, Interdisciplinary Programs University of Florida Colleges of Medicine Engineering 09/30/07 to 05/30/16 Wilder Inaugural Chair Research Professor, University of Florida College of Medicine 07/01/07 to 05/30/16 Professor with Permanent Tenure, Departments of Pediatrics and Neurology University of Florida College of Medicine 07/01/07 to 05/30/16 Joint Professor, Department of Biomedical Engineering University of Florida College of Medicine 07/01/07 to 05/30/16 Affiliate Professor, Department of Neuroscience, University of Florida College of Medicine 09/01/05 to 06/30/07 Associate Professor with Tenure, Departments of Pediatrics and Neurology, University of Florida College of Medicine 09/01/05 to 06/30/07 Affiliate Associate Professor, Department of Neuroscience University of Florida College of Medicine 09/01/05 to 06/30/07 Joint Associate Professor, Department of Biomedical Engineering, University of Florida College of Engineering 07/01/98 to 08/01/05 Assistant Professor, Department of Pediatrics and Neurology University of Florida College of Medicine 07/01/98 to 08/01/05 Affiliate Assistant Professor, Department of Neuroscience University of Florida College of Medicine 07/01/98 to 08/01/05 Joint Assistant Professor, Department of Biomedical Engineering, University of Florida College of Engineering 12/20/90 to 06/30/92 Research Associate, Department of Cell Biology, University of Valparaiso School of Medicine 06/01/81 to 03/01/82 Research Technician, Department of Anatomy, Case Western Reserve University, Cleveland, OH 06/01/76 to 05/31/81 Chemist, Diamond Shamrock Corporation, Cleveland, OH Clinical Services 11/20 Inpatient and outpatient Pediatric Neurologist Ward Attending and Consultant, University of Missouri Health 06/30/16 to 05/31/20 In Patient Pediatric Neurologist Ward Attending and Consultant, UNC Health, 4 months/year Pediatric Epileptologist Ward Attending, UNC Health, 4 months/year

Paul R. Carney, MD 2 Curriculum Vitae September, 2020

Clinical Neurophysiology Attending, UNC Health, 4 months/year reading outpatient EEG, inpatient video-EEG, all extra- and intraoperative cortical mapping studies, and evoked potentials) Outpatient Pediatric Neurologist, UNC Health, 4 half days/week 07/01/98 to 06/15/16 Outpatient Pediatric Neurologist, UF Health/Shands Health, 4 half days/week 07/01/98 to 06/15/16 In Patient Pediatric Neurologist Ward Attending and Consultant, UF Health/Shands Health, between 5 months/year to 11 months/year 07/01/98 to 06/15/16 Pediatric Neurologist/Sleep Medicine/Clinical Neurophysiology Attending, 4 to 11 months/year Administrative Appointments 10/19/20 to present Chief, Division of Pediatric Neurology, University of Missouri at Columbia Missouri 06/30/16 to 06/15/20 Director, Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill 09/01/04 to 06/15/16 Founding Director for Research and Innovation, Wilder Research Center of Excellence, University of Florida College of Medicine 09/01/10 to 06/30/12 Director, Pediatric Neurology Fellowship, University of Florida College of Medicine 07/01/02 to 06/30/12 Director, Division of Pediatric Neurology, Department of Pediatrics, University of Florida College of Medicine 07/01/99 to 06/30/12 Medical Director, Comprehensive Pediatric Epilepsy Program University of Florida Health Shands Hospital 07/01/99 to 06/30/12 Medical Director, Pediatric Neurodiagnostic Laboratory University of Florida Health Shands Hospital 08/15/01 to 06/30/02 Interim Director, Division of Pediatric Neurology Department of Pediatrics, University of Florida College of Medicine Certifications and Licensures Diplomate of the American Board of Psychiatry and Neurology with Special Qualification in Child Neurology - Certificate No. 11544, Recertified on 10/30/2017 through 2027 Missouri State Board for the Healing Arts, 2019044723, 11/25/2019 through 01/31/2021 North Carolina Medical Board, 2016-01430, 06/2016 through 07/21//2021 Florida Medical Board, ME 76167, 06/1998 through 01/31//2022 Michigan Medical Board, 4301063652, 04/06/1998 through 01//31/2008

Paul R. Carney, MD 3 Curriculum Vitae September, 2020

Michigan Medical Board, 4351022940, 07/94 through 04/98 Ohio Medical Board, 07/1992 through 06/1994 ECFMG certificate 0-462-980-4 NPI Number 1750327938 Awards Fellow (elected), American Epilepsy Society, October 2019 Tenure, University of Missouri at Columbia, 2019 Charter member, National Institutes of Health Acute Neural Injury and Epilepsy Study Section, July 2017 to June 2021 National Professional Advisory Board Member (elected), Epilepsy Foundation of America, July 2014 to June 2021 Healthcare and Biotech Council Member (elected), Gainesville Florida Chamber of Commerce, May 2017 to June 2020 Tenure, University of North Carolina at Chapel Hill, 2017 Castle Connolly Top Doctors in America Honorary Award, 2008 to 2017 B.J. and Eve Wilder Endowed Professor in Epilepsy Research, University of Florida College of Medicine August 2007 to June 2016 International Association of Pediatricians ‘Top Pediatrician in Gainesville’ award April 2014 Epilepsy Foundation’s National Professional Advisory Board member (elected), March 2014 Epilepsy Foundation of America, Florida (elected), August 2011 to June 2014 Patients' Choice Award, 2011 Compassionate Doctor Award, 2011 American Pediatric Society ‘Most Outstanding’ New Member Award, 2011 American Neurological Association Fellow (elected), 2010 Fourth International Workshop on Seizure Prediction, 2009 Faculty Research Prize in Clinical Science, University of Florida, 2009 Chilean Child-Adolescent-Psychiatry-Neurology Society, 2006 Tenure, University of Florida, 2005 The William Pierskalla ‘best paper award’ for research excellence, 2004 Society for Pediatric Research Fellow (elected), 2000 Excellence in Teaching Award - University of Florida Department of Pediatric, 1999 American Academy of Pediatrics, 1998 Doctor of Medicine with Honors, 1990 National Research Service Award, National Science Foundation, 1985

Paul R. Carney, MD 4 Curriculum Vitae September, 2020

John Huntington Scholarship for Undergraduate Studies, John Carroll University, 1980 Diamond-Shamrock Corporation Cooperative Educational Scholarship, 1980 Professional Activities Memberships and Societies American Neurological Association (elected) American Pediatric Society (elected) American Clinical Neurophysiology Society (elected) Child Neurology Society (elected) Chilean Society of Medicine (honorary) Pediatric Academic Society (elected) Society of Pediatric Research (elected) Society for Neuroscience (elected) Society of Computational Neuroscience (elected) Angelman Syndrome Foundation American Academy of Pediatrics American Epilepsy Society American Academy of Neurology American Academy of Sleep Medicine Journal Reviewer Pediatric Neurology, Epilepsia, Journal of Child Neurology, Journal of Clinical Neurophysiology, Lippincott Williams and Wilkins Publishers, Psychosomatic Medicine, Basic and Clinical Pharmacology & Toxicology, ACTA Neuropsychiatrica, Sleep, Experimental Medicine and Biology Society IEEE, Clinical Pediatrics, Epilepsy and Behavior, Computers in Biology & Medicine, Journal of Pharmacology & Experimental Therapeutics, Journal of Pediatric Neurology, American Academy of Neurology (Sleep Section), The FASEB Journal, Journal of Pediatric Neurology, IEEE Transactions on Biomedical Engineering American Academy of Neurology, Scientific Abstract Reviewer, EURASIP Journal on Advances in Signal Processing, Chaos, Journal of Neural Engineering, IEEE, Bentham Science Publishers E-Books, Neuroinformatics, Brain, Biomedical Signal Processing and Control, Medical Engineering & Physics, Experimental Neurology, Epilepsy & Behavior Case Reports, Biomedical Signal Processing & Control, Epilepsy & Behavior, Journal of Computational Neuroscience, Neuroscience, Annuals of Biomedical Engineering, PLOS-ONE, Annuals of Biomedical Engineering, NeuroImage, Neurobiology of Disease, Organization for Computational Neuroscience, Current Psychopharmacology Editorial Boards Journal Current Psychopharmacology, April 2020 to present Journal of Pediatric Epilepsy, January 2018 to present

Paul R. Carney, MD 5 Curriculum Vitae September, 2020

Journal of Pediatric Neurology, April 2014 to present Journal of Materials Science and Chemical Engineering, August, 2013 to present Recent Patents on Biomedical Engineering, March, 2007 to present Children, September 2012 to present, Associate Editor Computers in Biology and Medicine, September 2005 to 2016, Associate Editor Photoacoustic Tomography, 2013 Journal of Pediatrics, 2007 to 2013, Associate Editor Scientific Review Panels National Institutes of Health Fellowships: Biophysical, Physiological, Pharmacological and Bioengineering Neuroscience (2021/01 ZRG1 F03B-R (20) L, 10/22/2020 to 10/23/2020 Pediatric Formulations and Drug Delivery Systems and Psychoactive Surveillance (ZRG1 MDCN-C (50) S), 08/06/2020-08/08/2020 Acute Neural Injury and Epilepsy Study Section, July 2017 to present (Charter Member, July 2017-June 2021) Acute Brain Injury and Recovery (ZRG1 BDCN-Y 02), June 2018 Acute Brain Injury and Regeneration (ZRG1 BDCN-Y 02 M), July 2017 Acute Neural Injury Epilepsy, June 2016 Brain Injury and Recovery, March 2016 Neurobiology of Mental Disorders and Addictions, July 2015 Epilepsy and Related Diseases, November 2015 Neurogenetics, Epilepsy, Technology, Neural Repair. October 2014 (Chair) Director's Early Independence Award Review, June, 2012 Epilepsy: Imaging, Surgery and Sleep Disorders, April 2012 Small Business: Clinical Neurophysiology, Devices, Auditory Devices and Neuroprosthesis, July 2011 ZNS1 SRB-B 31 Study Section, July 2011 (Chair) ZNS1 SRB-B (31), July 2011 Neurotechnology NT-B, February 2011 Small Business: Clinical Neurophysiology, Devices, Auditory Devices, and Neuroprosthesis, March 2011 (Chair) SBIR ETTN-K 10, February 2010 (Co-Chair) Clinical Neurophysiology, Devices, Auditory Devices and Neuroprosthesis, June 2010 Clinical Neurophysiology, Devices, and Neuroprosthetics, June, September 2007, February, June, October 2008, March 2009

Paul R. Carney, MD 6 Curriculum Vitae September, 2020

Neurotechnology Study Section Emerging Technologies and Training Neurosciences Integrated Review Group, October 2008, February 2009 Professional Organizations, Foundations, and other Federal Agencies Clinical Research Training Apprenticeship, Epilepsy Foundation of America, 2018 to 2021 American Academy of Neurology Research Program Applications, 2018, 2019, 2020 New Therapy Commercialization Grants program, Epilepsy Foundation of America, Fall 2018, Spring 2019 Pennsylvania Department of Health Review, May 2018 Epilepsy Foundation of America Innovation Research Programs, April, 2018 Organizational for Computational Neuroscience, April 2018 American Academy of Neurology Research Program, November 2017 Reviewer, University of Florida Division of Sponsored Research, Research Opportunity Fund Advisory Committee, American Epilepsy Society Research, 2005 to 2016 Computational Neuroscience Society, April 2016 Canadian Institutes of Health Research, January 2016 Medical Research Council, European Union, March 2014 Canadian Research Council, 2011 Graduate Student for Outstanding Research, Office of Graduate Education, Office of the Dean, College of Medicine, University of Florida, June 2009 Natural Sciences and Engineering Research Council of Canada, August 2007, July 2008 National/Professional Services Activities American Academy of Neurology Research Program Awards Program Reviewer, 2021 American Epilepsy Society Translational Research Committee, 2020 - 2022 American Clinical Neurophysiology Society Program Committee member, 2019-2021 Elected Advisory Board Member, Epilepsy Foundation’s National Professional Advisory Board, 2014 to 2022 Healthcare and Biotech Council Member (elected), Gainesville Florida Chamber of Commerce, May 2017 to June 2020 Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE), 2017-present American Pediatric Society Leadership Mentoring Program, 2013, 2016 American Neurological Association Scientific Committee abstract reviewer, 2013 American Pediatric Society Leadership Mentoring Program, 2013 American Epilepsy Society Pediatric Content Committee, December 2009 to 2012 American Academy of Neurology Scientific Program Committee, 2008 to 2012 American Epilepsy Society Scientific Program Committee Member, 2007 to 2012

Paul R. Carney, MD 7 Curriculum Vitae September, 2020

American Pediatric Society ‘Most Outstanding’ New Member Award, 2011 Elected Board Member, Florida Epilepsy Foundation, 2011 Chair, Society of Neuroscience Annual Meeting Nanosymposium on Optogenetics Tools Washington DC, 2011 Member, American Neurological Association136th Annual Meeting Scientific Program Committee, San Diego, CA, 2011 Member, American Academy of Neurology's Scientific Program Committee Subcommittee Sleep Disorders (Toronto), 2010 Mentor, American Epilepsy Society Junior Faculty Mentoring Program, 2010 Chair, Society for Neuroscience Clinical Epilepsy Nanosymposium, 2010 Fourth International Workshop on Seizure Prediction Scientific Advisor Committee, 2009 American Epilepsy Society Special Interest Group Committee Member, 2001 Invited Platform Moderator - American Epilepsy Society, 1998 National and Local Committee Professional Assignments and Service CBD 2020 Conference,12th Annual Chair Summit, Feb; 27-29, 2020, Chair Program committee, American Clinical Neurophysiology Society, 2019 to 2020 Board member, Greater Gainesville Region Economic Development Chamber of Commerce, 2017 to present Alachua Multi-County Migrant Education Program, 2014 to 2015 University of Florida Graduate Student Mentoring Award application reviewer, 2015 Florida Symposium on the NIH BRAIN Initiative 2014 Pediatric Content Committee Member, American Epilepsy Society, 01/1/2010 to 12/31/2012 Scientific Program Committee Member, American Epilepsy Society, 01/1/2010 to 12/31/2011 UF Epilepsy Monitoring Unit Advisory Committee Shands Children’s Hosp. 1998 to 2012 Member, Regional Training, Children Medical Services North Central Region invited talk on Pediatric Neurology, 2011 Member, University of Florida College of Medicine MD/PhD Educational Program, 2009 Advisory Board, University of Florida COE Dept. Biomedical Engineering, 2008 Member, University of Florida College of Medicine Neurology Chair search committee, 2008 Advisory Board, DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, University of Florida, 2006 Advisory Committee, Conference on Data Mining, Systems Analysis and Optimization in Neuroscience, University of Florida, 2006 Academic Graduate Committee, Department of Biomedical Engineering, UF COE, 2005 to 2006 Faculty Search Committee for the Department of Biomedical Engineering, UF College of Engineering, 2004 to 2006

Paul R. Carney, MD 8 Curriculum Vitae September, 2020

Co-Organizer, Conf Systems Analysis, Data Mining, Optimization in Biomedicine, UF, 2005 Ad Hoc Advisory Board Member, Dept. Biomedical Engineering, UF COE, 2005 Advisory Board, Data Mining in Biomedicine, UF College of Engineering, 2004 to 2005 Co-Organizer, Center for Applied Optimization, University of Florida, College of Engineering and McKnight Brain Institute, 2004 to 2005 Department of Pediatrics Outpatient Clinic Planning Committee, 2000 to 2004 Member, UF Department of Bioengineering Faculty Search Committee, University of Florida College of Engineering, 2003 Member, University of Florida McKnight Brain Institute Director search committee, 2003 Conference Co-organizer, Quantitative Neuroscience: Models, Algorithms, Diagnostic and Therapeutic Applications Conference, University of Florida, 2003 Department of Neurology Epilepsy Faculty search committee, University of Florida Division of Critical Care Faculty search committee, Department of Pediatrics, University of Florida, 2003 UF Sleep Disorders Program Planning Committee Shands Children’s Hospital, 2000 University of Florida Sleep Disorders Program Planning Committee, 2000 Department of Pediatrics Strategic Planning Committee, 2000 Selected Community Outreach and Mentoring Activities Health Care and Life Sciences Council, The Greater Gainesville Region CEO Council for Economic Outreach, 2017 to present Free Clinic physician volunteer, Alachua County Migrant Workers Program. 2013 to 2016 High school students’ supervision, UF Student Science Training Program, summer, 2011, 2012, 2015 Scientific Judge, Lincoln Middle School Science Fair, Gainesville, FL, winter, 2005 to 2016 State of Florida Medical Advisor to the Florida Birth-Related Neurological Injury Compensation Assoc., Tallahassee, FL, May 2003 to August 2008 UF College of Medicine medical student and pediatric house officer rural medicine expedition (Nicaragua), Feb. 2001, 2002, 2003, 2005, 2006 Teaching Activities At University of North Carolina School of Medicine Inpatient and outpatient pediatric and adult residency, pediatric neurology fellowship, clinical neurophysiology/epilepsy, 2016 to 2020 At University of Florida Colleges of Medicine and Engineering Course Director Inpatient and outpatient pediatric and adult residency, pediatric neurology fellowship, clinical neurophysiology/epilepsy, 1998 to 2016 E25, Pediatric Neurology, Department of Pediatrics, 3 semesters 2009-2016

Paul R. Carney, MD 9 Curriculum Vitae September, 2020

BME 6010, Biomedical Engineering Clinical Preceptorship, College of Engineering, 15+ students, Fall, Spring, Summer 2005-2015 Lecture to Graduate Students, Fellows, Postdoctoral Teaching attending physician, Ped Neurology Series Dept. of Neurology, UF, 07/01/98 to 06/15/16 In-patient teaching attending, Pediatric Neurology, 07/01/98 to 06/15/16 Out-patient teaching attending, Ped Neurology, Epilepsy/Sleep Disorders Clinic 07/01/98 to 06/15/16 Lecturer, Neonatal Fellows Seminar Conference, Division of Neonatology, Department of Pediatrics, 07/01/98 to 06/15/16 General pediatrics morning conference attending, Department of Pediatrics, 07/01/98 to 06/15/16 Lecturer, Pediatric Neurology Morning Conference, Department of Pediatrics, 07/01/98 to 06/15/16 Lecturer, Epilepsy, Clinical Neurophysiology, Sleep Medicine, Dept. of Neurology, 07/01/98 to 06/15/16 Lecturer, Neuroscience course GMS 6007, Department of Neuroscience, 07/01/98 to 06/15/16 Lecturer, Physiology Graduate Level Course, Dept. of Biomedical Engineering, 07/01/98 to 06/15/16 Lecturer, School of Physician Assistant Studies, 07/01/98 to 06/15/16 Lecturer, Shands Epilepsy Laboratory, Neonatal seizures, 07/01/98 to 06/15/16 Lecturer, School of Physician Assistant Studies, 07/01/98 to 06/15/16 GMS-6029: Neurodegenerative Research: From Bench-to-Bedside, Spring, 2012 to 2016 MDU 4001-Translational Neuroscience, 2005 to 2016 MS6007, Neuroscience Course Department of Neuroscience, Fall, 2004 to 2016 Research Teaching BME7980 Doctoral research, credits 9, 2002 to 2016 ENG 4912 Engineering research, 2002 to 2016 Honors independent research (undergraduate) 4917, 2002 to 2016 BME6907 Biomedical engineering project, credits 3, 2002 to 2016 BME6971 Masters research, credits 9, 2002 to 2016 BME7979 Advanced research, credits 9, 2002 to 2016 PHA7979 Advanced research, credits 9, 2002 to 2016 EML7980 Doctoral research, credits 9, 2002 to 2016 EML7980-Doctoral Research, 2002 to 2016 ZOO4905-Individual studies, 2011, 2012

Paul R. Carney, MD 10 Curriculum Vitae September, 2020

Student Preceptorships MEL 4012 Undergraduate Physician Shadowing Program, 2005 to 2016 MUD 4004 Fall, 2013, 2014 Resident and Fellows Teaching Pediatrics, 5 to 6 residents every 4 weeks, 1998 to 2016 Pediatric neurology, 2 fellows per year, 8 to 12 weeks per year, 1998 to 2016 Adult neurology, 1-2 residents per week, 8 to 12 weeks per year, 1998 to 2016 Clinical neurophysiology and epilepsy, 1 fellow per year, 8 to 12 weeks inpatient EMU and 1 day per week reading EEG, EP, PSG studies, 1998 to 2016 Various – nursing students, pharmacy students, undergraduate studies. At least 1 student per 8 to 12 weeks in patient rotation. Outpatient 1 to 2 full days, 1998 to 2016 At University of Michigan School of Medicine Fellow Lecturer, Neurology resident’s neuroscience course, 8 lectures, July, 1996 to June, 1998 Mentoring Trainees

Name Position Date Degree Current Position Becker, Daniel PhD thesis advisor, UF 1998-2002 PhD Assistant Professor University of Department of Neurology, Univ. of Florida Penn Nair, Sandeep PhD thesis advisor, UF 2002-2007 PhD Senior Project Manager University of Biogen Pharmaceuticals, Inc. Florida Bongiolatti, Susan PhD thesis advisor, UF 2003-2008 PhD Assistant Professor University of Dept. of Health Psychology, CWRU Florida Meyers, Stephen PhD thesis advisor 2005-2010 PhD Associate Postdoctoral Fellow, University of Foley & Lardner LP, Boston UF Florida Parekh, Mansi PhD thesis advisor 2005-1010 PhD Postdoctoral Fellow Postdoctoral Fellow, University of Stanford University UF Florida Zafar, Rabia Master’s, PhD thesis 2005-2010 PhD Pediatric resident advisor, UF University of Washington University Postdoctoral Fellow, Florida UF Kantorovich, PhD thesis advisor, UF 2007-2012 PhD Postdoctoral Fellow, UC Irvine Svetlana University of Scientist, Zogenix, Inc. Florida Bennett, Eric Master’s thesis 2009-2012 Master’s Biological Scientist, UCSF advisor, UF University of Founder, Frontier Bio Florida Winters, Jason PhD thesis advisor, UF 2009-2012 Master’s Principal Software Engineer University of The MathWorks Florida

Paul R. Carney, MD 11 Curriculum Vitae September, 2020

Shore, Matthew Master’s and PhD 2009-2012 Master’s Program Manager thesis advisor, UF University of Google, Inc. Florida Stanley, David PhD thesis advisor, UF 2009-2013 PhD Postdoctoral Fellow University of Boston University Florida Agarwal, Nikita PhD thesis advisor, UF 2011-2015 PhD Manager and Application Scientist, University of Bruker BioSpin PCI Florida Delgado, Frank Masters and PhD thesis 2010-2016 PhD Postdoctoral Fellow advisor, UF University of University of Florida Florida Natarajan, Gowri Masters and PhD thesis 2011-2016 PhD Postdoctoral Fellow advisor Postdoctoral University of UNC Chapel Hill Fellow, UF Florida Anderson, PhD thesis advisor 2012-2017 PhD Research Assistant Professor Christopher Postdoctoral Fellow, University of UNC Chapel Hill UF Florida Zildani, Maria Master’s thesis advisor 2012-2013 Masters Postdoctoral fellow (French foreign University of University of Paris exchange student), UF Florida Doan, Brandon Master’s thesis 2011-2013 Masters Team Lead advisor, UF University of Ziehm Imaging Florida Magdoom Kulam PhD thesis committee, TBA PhD Postdoctoral Fellow Najmudeen UF University of Eunice Kennedy Shriver National Florida NICDH Ana Bohorquez PhD thesis committee, 2012-2017 PhD Scientist UF University of Nanotherapeutics, Inc. Florida Shengpo Fang PhD thesis committee, 2013-2017 PhD Process Integration Engineer UF University of Intel, Inc. Florida Aditya Kasinadhuni PhD thesis committee, 2011-2016 PhD Lead Systems Engineer UF University of GE Healthcare, Inc. Florida Wei Dai PhD thesis committee, 2000-2015 PhD Drug Manufacturing Technician UF University of Abbott Molecular, Inc. Florida Tao Zhang PhD thesis committee, 2001-2015 PhD Software Engineer UF University of Microsoft, Inc. Florida Liju Ji PhD thesis committee, 2009-2014 PhD Software Engineer UF University of Phillips, Inc. Florida Shivakeshavan PhD thesis committee, 2009-2014 PhD Postdoctoral Fellow Ratnadu UF University of SUNY Florida Shruthi Bharadwaj PhD thesis committee, 2008-2013 PhD Scientist UF University of Novartis, Inc. Florida Manu Nandan PhD thesis committee, 2008-2013 PhD Software Engineer, Gainesville UF University of Florida Florida Vikram Munikoti PhD thesis committee, 2008-2013 PhD Deputy Director, Laboratory UF Operations

Paul R. Carney, MD 12 Curriculum Vitae September, 2020

University of US Department of Homeland Florida Security

Luis Colon PhD thesis committee, 2008-2013 PhD Assistant Professor UF University of UC Irvine Florida Rachel Speisman PhD thesis committee, 2008-2013 PhD Health Science Policy Analyst UF University of NIH NIMH Florida Gonzalo Fernando PhD thesis committee, 2010-2013 PhD Assistant Professor, University of Casanova Garcia UF University of Columbia Florida Lan Hoang-Minh PhD thesis committee, 2007-2012 PhD Postdoctoral Fellow, University of UF University of Florida Florida Katherine Junger PhD thesis committee, 2008-2012 PhD Assistant Professor, University of UF University of Cincinnati Florida Anit Salgia PhD thesis committee, 2008-2012 PhD Programmer UF University of Arbor Research Florida Siddharth Ray PhD thesis committee, 2008-2012 PhD Researcher, Texas Children’s UF University of Hospital Florida Founder at Nextel.i.o. Indore Area, India Phil Barish PhD thesis committee, 206-2011 PhD Vice President of Business UF University of Development Florida AbSci, Inc., Portland, Oregon Garrett Astary PhD thesis committee, 2006-2011 PhD Engineer, GE Health UF University of Florida Mackenzie PhD thesis committee, 2005-2010 PhD Postdoctoral Fellow, University of Hoffmann UF University of Oregon Florida Hector Sepulveda PhD thesis committee, 2005-2010 PhD Federal Agent, Federal Bureau of UF University of Investigation Florida Amy Roux PhD thesis committee, 2004-2009 PhD Teacher, St. Petersburg Florida UF University of Florida Chang Chia Liu PhD thesis committee, 2003-2008 PhD Assistant Professor UF University of Johns Hopkins University School of Florida Medicine Anil Bollimunta PhD thesis committee, 2005-2008 PhD Postdoctoral Fellow, UCSF UF University of Florida Mandy Layman PhD thesis committee, 2004-2008 PhD Dietician, Nemours Florida UF University of Florida Chelsey Durgin PhD thesis committee, 2003-2008 PhD Orthopedic surgeon, FSU UF University of Florida Alex Cadotte PhD thesis committee, 2002-2007 PhD Health Scientist UF University of Food and Drug Administration Florida

Paul R. Carney, MD 13 Curriculum Vitae September, 2020

Sandeep Nair Master’s thesis 2001-2006 Master’s Clinical Project Manager committee, UF University of Quintiles, Inc. Florida Sobra Fritz PhD thesis committee, 1999-2003 PhD Assistant Professor, Emory UF University of University Florida Christine Girard Master’s thesis 2011-2013 Master’s, UF Graduate student committee, UF University of Illinois Lauren Jones Master’s thesis 2009-2011 Master’s, UF Nutritionist, Florida Hospital committee, UF (Advent Health) Edgard Andrade Master’s thesis 2009-2011 Master’s, UF Assistant Professor, University of committee, UF Florida, Private Practice Adam Fletcher Master’s thesis 2008-2010 Master’s, UF R&D Engineer committee, UF Medtronic, Inc. Mamta Wankhede Master’s thesis 2008-2010 Master’s, UF Postdoctoral Fellow, UCSF committee, UF Lan Hoang Minh Master’s thesis 2006-2008 Master’s, UF Postdoctoral Fellow, University of committee, UF Florida Amanda Layman Master’s thesis 2002-2004 Master’s, UF Dietician, Nemours Hospital committee, UF Orlando, Florida Xinyue Liu PhD thesis committee, 2011-2015 PhD Associate Principal Scientist UIF University of Merck, Inc. Florida Taylor Kuhn PhD thesis committee, 2010-2014 PhD Research Assistant Professor, UCLA UF University of Florida Sheng-Feng Yen PhD thesis committee, 2008-2011 PhD UIF University of Florida Justin C. Sanchez Postdoctoral Fellow 2004-2006 PhD Assistant Professor, University of University of Florida, University of Florida, University of Miami, UF Florida Director, BTO DARPA, Life Sciences Research Technical Fellow at Battelle Memorial Institute Wendy Norman Postdoctoral Fellow 2003-2008 PhD Assistant Professor, University of University of Florida, University of Florida UF Florida Junli Zhao Postdoctoral Fellow 2008-2020 PhD, First Research Scientist, University of University of Florida, Capitol North Carolina UF University, Beijing Yeong Jung Park Medical Student 2010-2012 MD, University Resident, University of South Fellowship Advisor, of Florida Carolina UF Phillip Chong Medical Student 2009-2011 MD, University Fellowship Advisor, of Florida UF Christa Matrone Medical Student 2010-2011 MD, University Resident, Boston Children’s Fellowship Advisor, of Florida Hospital, Harvard University UF Jenny Wilkerson Medical Student 2008-2009 MD, University Pediatric Neurologist Fellowship Advisor, of Florida UF

Paul R. Carney, MD 14 Curriculum Vitae September, 2020

Shahrukh Bengali Junior Honors Medical 2016-2018 MD Medical Student, University of Student Advisor, UF University of Florida Florida Angelique Junior Honors Medical 2012-2014 MD, University Resident, Nationwide Children’s Boutzoukas Student Advisor, UF of Florida Hospital Kathryn Helmick Medical Student 2008-2009 MD, University Fellowship Advisor, of Florida UF Christian Svetics Undergraduate 2013-2014 BS, University Engineering Student, University of Research Advisor, UF of Florida Florida Ahmad Ahmad Undergraduate 2013-2014 BS, University Research Advisor, UF of Florida Jessica McElroy Undergraduate 2011-2012 BS, University Medial Student Nova University Research Advisor, UF of Florida Kami Veltri Undergraduate 2009-2011 BS, University Medical student GW University Research Advisor, UF of Florida Jonathan Im High School SSTP 2011 BS, Duke Student, Duke University Advisor, UF University Bin Gu Postdoctoral 2016-2020 PhD, Duke Postdoctoral Fellow Committee Advisor, University University of North Carolina at UNC, Chapel Hill Chapel Hill, Assistant Professor, Neuroscience, Ohio State University Christina Catavero PhD thesis committee, 2018-2020 BS, University Graduate Student UNC, Chapel Hill of North University of North Carolina at Carolina at Chapel Hill Chapel Hill

Kellie Kronitzer Undergraduate 2017-2019 BS, University Graduate Student Research Advisor, of North North Carolina State UNC, Chapel Hill Carolina at Chapel Hill Changquing Xu Scientist 2020- PhD, First present Peking University Journal Publications (*Indicates student co-author; + indicates postdoctoral fellow co-author) 1. Gu B,+ Zhu M,* Glass MR,* Rougié M, Nikolova VD,* Moy SS, Carney PR, Philpot BD. Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. J Clin Invest. 2019 Dec 2;129(12):5462-5467. PMID: 31503547. 2. Aliyu MH, Abdullahi AT, Iliyasu Z, Salihu AS, Adamu H, Sabo U, Garcia JP, Abdullahi SU, Mande A, Xian H, Yakasai HM, Schootman M, Ingles DJ, Patel AA, Yakasai A, Curry- Johnson S, Wudil UJ, DeBaun, MR, Trevathan E, the BRIDGE Advisory Panel, Birbeck G, Carney P, Glauser T, Kakooza A, Pearl, Wabulya PA, Wheless J, Wilmshurst J, Bridging the childhood epilepsy treatment gap in northern Nigeria (BRIDGE): Rationale and design of pre-clinical trial studies. Contemp Clin Trials Commun. 2019 Apr 16;15:100362. 3. Leibowitz J,* Natarajan G,* Michael A. King MA, Carney PR, Ormerod BK. Sustained somatostatin gene expression reverses kindling-induced increases in the number of dividing Type-1 neural stem cells in the hippocampi of behaviorally responsive rats. Epilepsy Res. 2019 Feb; 150:78-94. 4. Magdoom KN,* Delgado F,* Bohórquez AC,* Brown AC,* Carney PR, Rinaldi C, Mareci TH, Ewing JR, Sarntinoranont M. Longitudinal evaluation of tumor microenvironment in rat

Paul R. Carney, MD 15 Curriculum Vitae September, 2020

focal brainstem glioma using diffusion and perfusion MRI. J Magn Reson Imaging. 2018. Oct 14. PMID:30318760. 5. Dai X,* Zhang T,* Yang H,* Tang J,* Carney PR, Jiang H. Fast noninvasive functional diffuse optical tomography for brain imaging. J Biophotonic. 2018 Mar;11(3). PMID: 28696034. 6. Kuhn T,* Gullett JM,* Boutzoukas AE,* Bohsli A, Mareci TH, Fitzgerald DB, Carney PR, Bauer RM. Temporal lobe epilepsy affects spatial organization of entorhinal cortex connectivity. Epilepsy Behav, 2018 Sept, 19;88:87-95. PMID: 30243111. 7. Liu X,* Carney PR, Bussing R, Segal R, Cottler LB, Winterstein AG. Stimulants Do Not Increase the risk of seizure-related hospitalizations in children with epilepsy. Child Adolesc Psychopharmacol. 2017 Oct 13. PMID: 29028437. 8. Liu X,* Carney PR, Bussing R, Segal R, Cottler LB, Winterstein AG. Trends in antiepileptic drug use in children and adolescents with epilepsy. Pediatr Neurol. 2017 May 29 PMID: 28676250. 9. Anderson CL,* DeMarse TB, Febo M, Johnson CR, Earnest V,* Carney PR. Cannabidiol for the treatment of drug resistant epilepsy in children: Current state of research. J. Ped Neuro 2017. 10. Huang L,* Ni X, Ditto WL, Spano M, Lai YC, Carney PR. Detecting and characterizing high-frequency oscillations in epilepsy: a case study of big data analysis. R Soc. Open Sci. 2017 Jan 18;4(1):160741 PMID: 28280577. 11. Middlebrooks EH, Quisling RG, King MA, Carney PR, Roper S, Colon-Perez LM, + Mareci TH. The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences. Surg Radiol Anat. 2017 Mar 12 PMID: 28286911. 12. Natarajan G,* Leibowitz JA,* Zhou J+, Zhao Y,+ King MA, Ormerod BK, Carney PR. Adeno-associated viral vector-mediated preprosomatostatin expression suppresses induced seizures in kindled rats. Epilepsy Res. 2017 Jan 7; 130:81-92 PMID: 2816743. 13. Geyer JD, Geyer EE, Fetterman Z, Carney PR. Epilepsy and restless legs syndrome. Epilepsy and Behavior. 2017: 68: 41-44. 14. Glushakov AV, Glushakova OY, Doré S, Carney PR, Hayes RL. Animal Models of Posttraumatic Seizures and Epilepsy. Methods Mol. Biol. 2016;1462:481-519. 15. Kuhn T,* Gullett JM,* Nguyen P,* Boutzoukas AE,* Ford A,+ Colon-Perez L,+ Triplett W, Carney PR, Mareci TH, Price CC, Bauer RM. Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based spatial statistics, probabilistic tractography and a novel graph theory metric. Brain Imaging Behav. 2016 Jun;10(2):533-47. 16. Dai W,* Astary GW,+ Kasinadhuni AK,* Carney PR, Mareci TH, Sarntinoranont M. Voxelized model of brain infusion that accounts for small feature fissures: Comparison with MR tracer studies. J Biomech Eng. 2016 May 1: 138 (5). 17. Zhang T, Zhou J, Carney PR, Jiang H. Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography. J Neurosci Methods. 2015: 240:28-36.

Paul R. Carney, MD 16 Curriculum Vitae September, 2020

18. Tolaymat A, Nayak A, Geyer JD, Geyer JD, Carney PR. Diagnosis and Management of Childhood Epilepsy. Current Problems in Pediatric and Adolescent Health Care. 2015; 1-17. 19. Yang H,* Zhang T,* Zhou J,+ Carney PR, Jiang H. In vivo imaging of epileptic foci in rats using a miniature probe integrating diffuse optical tomography and electroencephalographic source localization. Epilepsia. 2015 Jan; 56(1): 94-100. 20. Tang J, Zhou J+, Huang H, Zhang T,* Carney PR, Jiang H. Non-invasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats. J Cereb Blood Flow Metab. 2015 Aug;35(8):1224-32. 21. Colon-Perez LM,+ Spindler C,* Goicochea S,* Triplett W, Parekh M,+ Montie E, Carney PR, Price C, Mareci TM. Dimensionless, scale invariant, edge weight metric for the study of complex structural networks. PLoS One. 2015 Jul 14; 10(7): e0131493. 22. Colon-Perez LM,+ King M, Parekh M,+ Boutzoukas A,* Carmona E,* Couret M,* Klassen R,* Mareci T, Carney PR. High-field magnetic resonance imaging of the human temporal lobe. Neuroimage Clin. 2015 Aug 1; 9:58-68. 23. Zhang T, * Zhou J, + Jiang R, * Yang H, + Huabei Jiang H, Carney PR. Pre-seizure state identified by diffuse optical tomography. Sci. Rep. 2014 Jan 21; 4:3798. 24. Shivakesavan-Giridharan S*, Stefenscau RA+, Khargonekar PP, Carney PR, Talathi SS. Genesis of interictal spikes in the CA1: a computational investigation. Frontiers in Neural Circuits, 2014 Jan 27; 8:2. 25. Casanova F, * Carney PR, Sarntinoranont M. Effect of needle insertion speed on tissue injury, stress, and backflow distribution for convection-enhanced delivery in the rat brain. PLoS One, 2014 Apr 28; 9(4): e 94919. 26. DeMarse TB, Carney PR. Augmentation of cognitive function in epilepsy. Front Syst. Neurosci. 2014 Aug 14; 8: 147. 27. Casanova F, Carney PR, Sarntinoranont M. In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain. J Neurosci Methods. 2014 Nov 30; 237: 79-89. 28. Stanley DA, Talathi SS, Carney PR. Chronotherapy in the treatment of epilepsy. Chrono Physiology and Therapy. Dove press. 109-123; 26 November 2014. 29. Astary GW, * Peprah MK+, Fisher CR, * Stewart RL, Carney PR, Sarntinoranont M, Meisel MW, Manuel MV, Mareci TH. MR Measurement of Alloy Magnetic Susceptibility: Towards Developing Tissue-Susceptibility Matched Metals. Magn Reson. 2013 May 13; 233C: 49-55. 30. Carney PR. Special Issue on Epilepsy. Exp. Neurol. 2013 Jun; 244C: 1-3. 31. Stanley DA, * Talathi SS, Parekh MB, Cordiner DJ, * Zhou J+, Mareci TH, Ditto WL, Carney PR. Phase shift in hippocampal circadian rhythm during the latent period of epileptic rats. J Neurophysiology. 2013 Sep; 110(5): 1070-86. 32. Kantorovich S+, Astary GW+, King MA, Mareci TH, Sarntinoranont M, Carney PR. Influence of acute brain injury status epilepticus on convection-enhanced delivery in the rat hippocampus. PLoS One. 2013 Nov 8; 8(11): e80606.

Paul R. Carney, MD 17 Curriculum Vitae September, 2020

33. Boykin ER*, Khargonekar PP, Carney PR, Ogle WO, Talathi SS. Detecting effective connectivity in networks of coupled neuronal oscillators. J. Comput. Neurosci. 2012 Jun; 32(3): 521-38. 34. Zafar R*, King MA, Carney PR. Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development. Neurosci. Lett. 2012: 509: 87-91. 35. Kim JH*, Astary GW*, Kantorovich S*, Mareci TH, Carney PR, Sarntinoranont M. Voxelized Computational Model for Convection Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies. Ann Biomed. Eng. 2012; 40: 2043-58. 36. Kim JH*, Astary GW*, Nobrega TL*, Kantorovich S*, Carney PR, Mareci TH, Sarntinoranont M. Dynamic contrast-enhanced MRI of Gd-albumin delivery to the rat hippocampus in vivo by convection-enhanced delivery. J Neurosci. Methods. 2012 Jun 8; 209(1): 62-73. 37. Casanova F, * Carney PR, Sarntinoranont M. Influence of needle insertion speed on backflow for convection-enhanced delivery. J Biomech Eng. 2012 Apr; 134(4):041006. 38. Wang B*, Xiang L, Jiang MS*, Yang J*, Zhang Q*, Carney PR, Jiang H. Photoacoustic tomography system for noninvasive real-time three-dimensional imaging of epilepsy. Biomed Opt Express. 2012 Jun 1; 3(6): 1427-32. 39. Ji L*, Zhou J, Zafar R*, Kantorovich S*, Jiang R*, Carney PR, Jiang H. Cortical neurovascular coupling driven by stimulation of channelrhodopsin-2. PLoS One. 2012; 7(9): e46607. 40. Xiang L* Ji L,* Zhang T,* Wang B,* Yang J, * Zhang Q,* Jiang MS,* Zhou J,+ Carney PR, Jiang H. Non-invasive real-time tomographic imaging of epileptic foci and networks. NeuroImage. 2012 Nov 2; 66C: 240-248. 41. Talathi SS, Carney PR, Khargonekar PP. Control of neural synchrony using channel rhodopsin 2: a computational study. J Comput. Neurosci. 2011 Aug; 31(1): 87-103. Epub 2010 Dec 21. 42. Carney PR, Myers, S* Geyer JD. Seizure prediction: methods. Epilepsy & Behavior. 2011 Dec; 22 Suppl 1: S94-S101. 43. Geyer JD, Lichstein KL, Ruiter ME, Ward LC, Carney PR, Dillard SC. Sleep education for paradoxical insomnia. Behav. Sleep Med. 2011 Sep 30; 9(4): 266-72. 44. Talathi SS, Hwang D+, Carney PR, Ditto W. Synchrony with shunting inhibition in a feed forward inhibitory network. J Comput. Neurosci. 2010 Apr; 28(2): 305-21. 45. Astary GW, * Kantorovich S,* Carney PR, and Mareci TH, Sarntinoranont M. Regional convection enhanced delivery of gadolinium labeled albumin into the rat hippocampus in vivo. J Neurosci. Methods. 2010 Mar 15; 187 (1): 129-37. 46. Cadotte AJ+, DeMarse TB, Mareci TH, Parekh M,* Talathi SS, Hwang DU,* Ditto WL, Ding M, Carney PR. Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy. J Neurosci. Methods. 2010 May 30; 189(1): 121-9.

Paul R. Carney, MD 18 Curriculum Vitae September, 2020

47. Fisher N,* Talathi SS, Carney PR, Ditto WL. Effects on homeostatic spike rate. Biol. Cybern. 2010 May: 102 (5): 427-40. 48. Nandan M,* Talathi SS, Myers S,* Ditto WL, Khargonekar PP, Carney PR. Support vector machine algorithms for seizure detection in an animal model of chronic epilepsy. J Neural Eng. 2010 Jun; 7(3): 036001. 49. Parekh MB*, Carney PR, Sepulveda H*, Norman W+, King M, Mareci TH. Early MR diffusion and relaxation changes in the parahippocampal gyrus precede the onset of spontaneous seizures in an animal model of chronic limbic epilepsy. Exp. Neurol. 2010 Jul; 224(1): 258-70. 50. Geyer JD, Carney PR, Dillard SC, Davis L, Ward LC. Antidepressant medications, neuroleptics and prominent eye movements during NREM Sleep. J Clin. Neurophy. 2009 Feb; 26(1): 39-44. 51. Nair SP,* Shiau DS,+ Principe JC, Iasemidis LD, Pardalos PM, Norman WM,+ Kelly KM, Sackellares JC, Carney PR. An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent. Exp. Neurol. 2009 Mar; 216(1): 115-21. 52. Talathi SS+, Hwang DU+, Ditto WL, Mareci T, Sepulveda H*, Carney PR. Circadian control of neural excitability in an animal model of temporal lobe epilepsy. Neurosci. Lett. 2009 May 15; 455(2): 145-9. 53. Komalapriya C*, Romano MC*, Thiel M, Schwarz U, Kurths J, Simonotto J, Furman M, Ditto WL, Carney PR. Predictability of spontaneous limbic seizures using recurrence measures. Int. J. Bifurcation and Chaos. 2009:19(2): 605-617. 54. Cadotte A+, Mareci T, DeMarse T, Parekh M*, Rajagovindan R*, Ditto W, Talathi S, Hwang DU, Carney PR. Temporal lobe epilepsy: anatomical and effective connectivity. IEEE Trans Neural Syst. Retail. Eng. 2009 Jun; 17 (3): 214-23. 55. Gunduz A*, Sanchez JC+, Carney PR, Principe JC. Mapping broadband electrocorticographic motor control features to two-dimensional hand trajectories in humans’ motor control features. Neural Netw. 2009 Nov; 22(9): 1257-70. 56. Talathi SS, Hwang DU, Miliotis A*, Carney PR, Ditto WL. Predicting synchrony in heterogeneous pulse coupled oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug; 80:021908. 57. Saxonhouse M, Tarquinio D*, Carney P, Bennett J, Smith A, Hunger S, Geyer J. Low molecular weight heparin use in a case of noncardiogenic multifocal perinatal thromboembolic stroke. Adv. Hematol. 2009:153643. 58. Kumar R*, Vemuri BC, Wang F*, Syeda-Mahmood T*, Carney PR, Mareci TH. Multi-fiber reconstruction from DW-MRI using a continuous mixture of hyperspherical von Mises- Fisher distributions. Inf. Process Med. Imaging. 2009: 21:139-50. 59. Sanchez JC+, Gunduz A*, Carney PR, Principe JC. Extraction and localization of mesoscopic motor control signals for human ECoG neuroprosthetics. J Neurosci Methods. 2008:167 (1): 63-81.

Paul R. Carney, MD 19 Curriculum Vitae September, 2020

60. Wang Q*, Liang X*, Liu Z, Zhang Q*, Carney PR, Jiang H. Visualizing localized dynamic changes during epileptic seizure onset in vivo with diffuse optical tomography. Med Phys. 2008; 1: 216-224. 61. Zhang Q*, Liu Z, Carney PR, Yuan Z*, Chen X+. Roper SN, Jiang H. Noninvasive imaging of epileptic seizures in vivo using photoacoustic tomography. Phys. Med. Biol. 2008 53:1921-1931. 62. Talathi SS+, Hwang DU+, Ditto WL, Spano M, Myers SM*, Winters J*, Simonotto J*, Carney PR. Non-parametric early seizure detection in an animal model of temporal lobe epilepsy. J. Neural Eng. 2008 Mar; 5 (1): 85-98. 63. Stacpoole PW, Gilbert LR, Neiberger RE, Carney PR, Valenstein E, Theriaque DW, Shuster JJ. Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. Pediatrics. 2008 May: 121(5): e1223-8. 64. Hwang Dong-UK+, Talathi S+, Carney PR, Ditto W, Myers S*, Norman W, Simonotto J*. High frequency oscillations in the limbic rat model of temporal lobe epilepsy. Comp Neurosci. 2007. 65. Martynyuk AE, Ucar DA, Yang DD, Norman WM+, Carney PR, Dennis DM, Laipis PJ. Epilepsy in phenylketonuria: A complex dependence on serum phenylalanine levels. Epilepsia. 2007 Jun; 48(6): 1143-50. 66. Jian B*, Vemuri BC, Ozarslan E+, Carney PR, Mareci T. A novel tensor distribution model for the diffusion weighted MR signal. NeuroImage. 2007 Aug 1; 37 (1): 164-76. 67. Ramirez-Manzanares A*, Rivera M*, Vemuri BC, Carney P, Mareci T. Diffusion basis functions decomposition for estimating white matter intra-voxel fiber geometry. IEEE Transactions on Medical Imaging. 2007: 26:1091-1102. 68. Talathi SS+, Hwang DU+, Ditto W, Carney PR. Early seizure detection in an animal model of temporal lobe epilepsy, Data Mining, Systems Analysis and Optimization in Biomedicine, AIP Conf Proc. 2007; 953:292-307. 69. Nair S*, Sackellares JC, Shiau DS+, Norman W+, Dance L, Pardalos P, Principe JP, Carney PR. Effects of acute hippocampal stimulation on EEG dynamics. IEEE Med Biol. 2006; 1: 4382-6. 70. Mishra M*, Jones B*, Simonotto JD*, Furman MD+, Norman W+, Liu Z, DeMarse TB, Carney PR, Ditto WL. Pre-ictal correlation and entropy analysis of microwire data from an animal model of limbic epilepsy. IEEE Eng. Med Biol. 2006; 1: 1605-7. 71. Chaovalitwongse WA*, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS+, Sackellares JC. Reply to comments on Performance of a seizure-warning algorithm based on the dynamics of intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K. Epilepsy Res. 2006 Oct: 71(2-3): 241-2. 72. Simonotto JD*, Myers SM*, Furman MD+, Norman WM+, Liu Z, DeMarse TB, Ditto WL, Carney PR. Coherence analyses over the latent period of epileptogenesis reveal that high- frequency communication is increased across hemispheres in an animal model of limbic epilepsy. IEEE Eng. Med Biol. 2006; 1:1154.

Paul R. Carney, MD 20 Curriculum Vitae September, 2020

73. Nelson R*, Myers S*, Simonotto J*, Furman M+, Spano M, Norman W+, Liu Z, DeMarse T, Ditto W, Carney PR. Detection of high frequency oscillations with Teager energy in an animal model of limbic epilepsy. IEEE Eng. Med Biol Soc. 2006; 1: 2578-80. 74. Sanchez JC, Carney PR, Principe JC. Analysis of amplitude modulated control features for ECoG neuroprosthetics. IEEE Eng. Med Biol. 2006;1: 5468-71. 75. Qizhi Z*, Liu Z, Carney PR, Jiang H. Imaging epilepsy using finite element-based photoacoustic tomography: initial in vivo results. Biomedical Optics Tech Dig. ME18: 2006. 76. Geyer JD, Carney PR, Gilliam F. Focal epileptiform spikes in conjunction with k- complexes. J Clin Neurophysiology. 2006 Oct; 23(5): 437-440. 77. Sanchez JC+, Mareci T, Norman W+, Principe J, Ditto W, Carney PR. Evolving into epilepsy: Multiscale electrophysiological analysis and imaging in an animal model. Exp Neurol. 2006 Mar; 198(1): 31-47. 78. Nair SP*, Shiau DS+, Iasemidis LD, Norman WM+, Pardalos PM, Sackellares CS, Carney PR. Seizure predictability in an experimental model of epilepsy. Proc Quant Neurosci Conf. 2006; 213-220. 79. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Pediatric Neurol. 2006 Feb; 34(2): 127-31. 80. Miller J, Carney P. Central hypothyroidism with oxcarbazepine therapy. Pediatric Neurol. 2006 Mar; 34(3): 242-4. 81. Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell E, Felitsyn NM, Gilmore R, Greer M, Henderson G, Hutson AD, Neiberger R, O'Brien R, Perkins LA, Quisling R, Shroads AL, Shuster JJ, Silverstein JH, Theriaque DW, Valenstein E. A controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics. 2006 May: 117(5): 1519-1531. 82. Sanchez JC+, Alba N*, Nishida T, Batich C, Carney PR. Structural modifications in chronic microwire electrodes for cortical neuroprosthetics. IEEE TNSRE. 2006: 14(2): 217-221. 83. Chaovalitwongse WA*, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS, Sackellares JC. Reply to comments on Performance of a seizure warning algorithm based on the dynamics of intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K. Epilepsy Res. 2006 Nov; 72(1): 85-7. 84. Pardalos PM, Boginski VL, + Prokopyev OA, * Suharitdamrong W, Carney PR, Chaovalitwongse W,* Vazacopoulos A. Optimization Techniques in Medicine. In: Eds. Audet C, Hansen P, Savard G. Essays and Surveys in Global Optimization. Springer, 2005; 151-173. 85. Sanchez JC,+ Principe JC, Carney PR. Is neuron discrimination preprocessing necessary for linear and nonlinear brain machine interface models? 11th Inter Conf on Human-Computer Interaction. 2005; 1100-15. 86. Iasemidis LD, Shiau DS,+ Pardalos PM, Chaovalitwongse W,* Narayanan K, Prasad A,* Tsakalis K, + Carney PR, Sackellares JC. Long-term prospective on-line real-time seizure prediction. Clin Neurophysiology. 2005 Mar: 116(3): 532-44.

Paul R. Carney, MD 21 Curriculum Vitae September, 2020

87. Chaovalitwongse W* Iasemidis LD, Pardalos PM, Shiau DS,+ Sackellares JC, Carney PR. Performance of a seizure warning algorithm based on the dynamics of intracranial EEG. Epilepsy Res. 2005 May: 64(3): 93-113. 88. Dharnidharka VR, Carney PR. Isolated idiopathic hypomagnesaemia presenting as aphasia and seizures. Pediatric Neurol. 2005 Jul; 33(1): 61-5. 89. Shiau DS+, Nair SP*, Iasemidis LD, Norman W+, Principe JC, Pardalos PM, Suharitdamrong W*, Cho J, * Sackellares JC, Carney PR. Seizure warning and dynamic response to electrical stimulation in a rodent model of chronic limbic epilepsy. IEEE Engineering in Medicine and Biology.2005: 95-100. 90. Iasemidis LD, Shiau DS+, Pardalos PM, Chaovalitwongse W*, Narayanan K*, Prasad A*, Tsakalis K, + Sackellares JC, Carney PR. Long-term prospective on-line real-time seizure prediction. Clinical Neurophysiology. 2005; 116 (3): 532-544. 91. Chaovalitwongse W*, Pardalos PM, Iasemidis LD, Carney PR, Shiau DS,+ Suharitdamrong W*, Sackellares JC. A robust method for studying the dynamics of the intracranial EEG: Application to epilepsy. Epilepsy Res.2005; 64: 93-113. 92. Shiau DS+, Nair SP*, Iasemidis LD, Carney PR, Norman WM+, Principe JC, Pardalos PM, Suharitdamrong W*, Cho J*, Sackellares JC. Seizure warning and dynamic response to electrical stimulation in a rodent model of chronic limbic epilepsy. Proceedings of 3rd European Medical and Biological Conference, Prague, Czech Republic: Vol. 11, 2005. 93. Becker DA*, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood epilepsy. Epilepsy Behav. 2004: 5: 708-15. 94. Pardalos PM, Chaovalitwongse W,* Iasemidis LD, Sackellares JC, Shiau DS,+ Carney PR, Prokopyev OA*, Yatsenko VA. Seizure warning algorithm based on optimization and nonlinear dynamics. Math. Program Ser B. 2004:35-50. 95. Iasemidis LD, Pardalos PM, Shiau DS+, Chaowolitwongse W*, Narayanan K, Kumar S, Carney PR, Sackellares JC, Prediction of human epileptic seizures based on optimization and phase changes of brain electrical activity. Optimization Methods and Software. 2003:18(1): 81-104. 96. Yatsenko V, Carney P, Pardalos P, Sackellares JC, Shiau DS+. Control of chaotic systems: a practical application to epilepsy, Proc. of Second International Conference on Control Problems, Moscow, Institute of Control Problems. 2003; 205-218. 97. Yatsenko V, Sackellares C, Pardalos P, Carney P. Geometric models, fiber bundles and biomedical applications. Fifth International Conference: Symmetry in Nonlinear Mathematical Physics, Institute of Mathematics. Kiev, 2003; 195-217. 98. Iasemidis LD, Shiau DS+, Chaovalitwongse W*, Sackellares JC, Pardalos PM, Principe JC, Carney PR, Prasad A, Veeramani B, Tsakalis K. Adaptive epileptic seizure prediction system. IEEE Trans Biomed Eng. 2003 May: 50(5): 616-27. 99. Becker DA, * Fennell, EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy Behav. 2003: 4(6): 651-8. 100. Stickler DE, * Carney PR, Valenstein ER. Juvenile-onset Leigh syndrome with an acute polyneuropathy at presentation. Child Neurol. 2003; 18(8): 574-6.

Paul R. Carney, MD 22 Curriculum Vitae September, 2020

101. Glueckauf RL, Fritz SP, * Ecklund-Johnson EP, * Liss HJ, * Dages P, * Carney P. Videoconferencing based family counseling for rural teenagers with epilepsy: Phase 1 findings. Rehab Psychol. 2002; 47(1): 49-72. 102. Kramer MJ, * LaRussa P, Tsai W, Carney P, Leber S, Gahagan S, Steinberg S, Blackwood A. Disseminated vaccine strain varicella as the acquired immunodeficiency syndrome-defining illness in a previously undiagnosed child. Pediatrics. 2001; 108(2): e39- 46. 103. Carney PR. Rasmussen's syndrome: Intractable epilepsy and progressive neurological deterioration from a unilateral central nervous system disease. CNS Spectrums. 2001: 6(5): 398-416. 104. MacLennan AJ, Carney PR, Zhu WJ, Chaves AH, Garcia J, Grimes JR, Anderson KJ, Roper SN, Lee N. An essential role for the H218/AGR16/Edg-5/LP (B2) sphingosine 1- phosphate receptor in neuronal excitability. Eur J Neurosci. 2001: 14(2): 203-9. 105. Okun MS,* Jummani RR,* Carney PR. Antiphospholipid-associated recurrent chorea and ballism in a child with cerebral palsy. Pediatric Neurol. 2000; 23(1): 62-3. 106. Tran TX, * Day JA,* Eskin TA, Carney PR, Maria BL. Rasmussen's syndrome: Etiology, clinical features, and treatment options. CNS Drugs. 2000: 14:343-354. 107. Kohrman MH, Carney PR. Sleep-related disorders in neurologic disease during childhood. Pediatric. Neurol. 2000; 23 (2): 107-13. 108. Herrmann DN, Carney PR, Wald JJ. Juvenile myasthenia gravis: treatment with immune globulin and thymectomy. Pediatric Neurol. 1998; 18:63-66. 109. Carney PR, Couve E. Cell polarity changes and migration during early development of the avian peripheral auditory system. Anat Rec.1989; 215:156-164. 110. Carney PR,* Silver J. Studies on cell migration and axon guidance in the developing distal auditory system of the mouse. J Comp Neur.1983; 225:359-369. Under Review Dai X, Zhang T, Yang H, Tang J, Carney PR, Jiang H. Fast non-invasive functional diffuse optical tomography for brain imaging in epilepsy studies. Epilepsia. Anderson C, Evans VF, DeMarse TB, Ormerod BK, Febo M, Johnson CR, Carney PR. Efficacy and safety of cannabidiol as a treatment for intractable generalized epilepsy in children: an open- label intervention trial. Epilepsy and Behavior. Xi L, Jin T, Zhou J, Carney P, Jiang H. Hybrid photoacoustic and electrophysiological recording of neurovascular communication in freely moving rats. Neuroimage. Textbooks Geyer JD, Patton T, Carney PR. Surviving & Thriving: Your Neurology Clerkship. Great Medicine Great Business Epub Series 2021. Greenfield LJ, Geyer JD, Carney PR. Reading EEGs: A Practical Approach. 2nd ed. Wolters Kluwer Health. 2020. Geyer JD, Carney PR. Atlas of Digital Polysomnography. 3rd Ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2017.

Paul R. Carney, MD 23 Curriculum Vitae September, 2020

Geyer JD, Gomez C, Henderson M, Carney PR. Sleep Apnea Survival Guide. JNP Media. 2016. Carney PR, Geyer JD, Berry R. Clinical Sleep Disorders, 2nd Ed. Lippincott- Williams & Wilkins, Inc., Philadelphia, 2012. Carney PR, Geyer JD. Clinical Neurophysiology: Methods and Clinical Applications. CRC Press. 2012. Greenfield LJ, Geyer JD, Carney PR. Reading EEGs: A Practical Approach. 1st ed. Lippincott- Williams & Wilkins, Inc., Philadelphia 2010. Carney PR, Geyer JD. Pediatric Practice: Neurology, McGraw Hill Professional Pubs, 1st edition. 2010. Geyer JD, Carney PR, Payne TT. Atlas of Digital Polysomnography. 2nd Lippincott-Williams & Wilkins, Inc., Philadelphia, 2009. Geyer JD, Potts DC, Marsh EE, Carney PR. Neurology for Wards and Mini-Boards: The Complete Medical Student Guide. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2009. Geyer JD, Keating JM, Potts DC, Carney PR. Neurology for the Boards, 3rd ed. Lippincott- Williams & Wilkins, Inc., Philadelphia, 2006. Carney PR, Geyer JD, Berry R, Clinical Sleep Disorders, 1st ed. Lippincott Williams & Wilkins, Inc., Philadelphia, 2005. Pardalos PM, Sackellares JC, Carney PR, Iasemidis LD. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers, Norwell, MA 2004. Geyer JD, Carney PR, Payne TT, Aldrich M. Atlas of Digital Polysomnography. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2000. Book Chapters Geyer JD, Carney PR. Artifacts. In: Review of Sleep Medicine. Ed. Alon Avidan. 4e, Chapter 45, 17 pages, Elsevier pub. 2017. Salardini A, Geyer JD, Carney PR. Genetic Neurological Diseases in the Adult. In: The Hospital Neurology Book. Eds. Arash Salardini and Jose Biller. Chapter 37, McGraw Hill pub, pages 154-169, 2016. Sprague-McRae JM, Lee JEM, Boyd JR, Carney PR, Leighty DD, Morrison LA, Rosenblum RK. Alterations of Consciousness New Patient Encounter Guide. In: Child Neurology Encounter Guides ACNN/CNS, Chapter 2, pages 92-127, 2014. Geyer JD, Carney PR. REM Sleep Behavior. In: Common Pitfalls in Sleep Medicine: Case- Based Learning. Eds. Ronald D. Chervin, Cambridge University Press. pages 132-155, 2014. Carney PR, Geyer JD, Tinuper P. Bisulli F, Provini F. Treating Epilepsy in the Presence of Sleep Disorders. Chapter 34, In: Medical and Surgical Treatment of Pediatric Epilepsy. Eds: Helen Cross, Michael Duchowny, Tracy Glauser, Edouard Hirsch, Alexis Arzimanoglou. McGraw-Hill Pubs, pages 155-182, 2012.

Paul R. Carney, MD 24 Curriculum Vitae September, 2020

Parr-Christmas J, Henderson MM, Geyer JD, Carney PR. Impact of Vascular Disorders on Sleep. In: Fundamentals of Sleep Technology. Eds.: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. Chapter 20, 2nd ed., pages 110-134, 2012. Henderson MM, Parr-Christmas J, Geyer JD, Carney PR. Impact of Degenerative Disorders on Sleep. In: Fundamentals of Sleep Technology. Eds: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. Chapter 21, 2nd ed., pages 148-172, 2012. Carney PR, Talathi SS, Geyer JD. Pediatric Sleep Issues. Chapter 21, pages 210-239, In: Sleep Medicine Updates, Ed. Octavian Ioachimescu, 1st edition, Bentham Publishing, E-Book, 2012 Geyer JD, Lichstein KL, Ruiter ME, Ward LC, Carney PR. Dillard SC. Sleep Education for Paradoxical Insomnia, Behavioral Sleep Medicine, 9:4, pages 266-272, 2011. Parr-Christmas J, Henderson MM Geyer JD, Carney PR. Impact of Vascular Disorders on Sleep. Fundamentals of Sleep Technology, 2nd edition, Chapter 20, pages 215-19, 2011. Henderson MM, Parr-Christmas J, Geyer JD, Carney PR. Impact of Degenerative Disorders on Sleep. Fundamentals of Sleep Technology, 2nd edition, Chapter 21, pages 220-27, 2011. Geyer JD, Carney PR, Dillard SC, Tsikhlakis JC. Sleep and Vascular Disorders. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 100-106, 2009. Carney PR, Geyer JD, Saxonhouse MA, Gomez CR, Malaty I. Pediatric Stroke. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 130-140, 2009. Geyer JD, Carney PR, Lichstein K, Dillard SC, Henderson MM. Sleep and Acute Stroke. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 301-307, 2009. Carney PR, Fisher N, Ditto WL, Geyer JD. Quantitative Sleep Monitoring. In: Quantitative EEG Analysis Methods and the Application. Editors: Shanbao Tong and Nitish V. Thakor, Artech House, Inc., of Norwood, MA, USA, pages 257-288, 2009. Carney PR. Alterations of Consciousness New Patient. In: Child Neurology Telephone Encounter Guides. Eds. Sprague-McRae, J, Rosenblum R, Morrison L. Association of Child Neurology Nurses, 1st ed., pages 23-62, 2009. Geyer JD, Carney PR, Parr J., Dillard SC. Sleep Disorders and Degenerative Neurologic Disorders. In: Fundamentals of Sleep Technology. Eds: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. 1st ed., 2007; 206-214. Henderson MM, Parr-Christmas J, Geyer JD, Carney PR. Sleep and Degenerative Neurologic Disorders. Textbook of Polysomnography. Association of Polysomnographic Technologists. Eds. L. Chiong, L. Shigley. Lippincott, Williams & Wilkins. pages 144-178, 2006. Parr-Christmas J, Henderson MM, Geyer JD, Carney PR. Sleep and Vascular Disease. Textbook of Polysomnography. Association of Polysomnographic Technologists. Eds. L. Chiong, L. Shigley. Lippincott, Williams & Wilkins, pages 205-238, 2006. Monographs Carney PR. Forward. In: A Ray of Hope: A Mother's Story of Love, Healing, and the Miracle of Medical Marijuana. Hope Grows Publishing. 2018.

Paul R. Carney, MD 25 Curriculum Vitae September, 2020

Carney PR. Jiang H. Noninvasive Functional and Cellular Imaging of Epilepsy. In: The Textbook of Neurophotonics in Brain Mapping. Eds: Babak Kateb. CRC Press, Taylor Francis Group pubs, pages 111-127, 2014. Carney PR. Applications of nanotechnology in epilepsy. In: Nanoneurosurgery and Nanoneuroscience. Eds: Babak Kateb and John D. Heiss. CRC Press, Taylor Francis Group pubs, pages 51-69, 2013. Carney PR, Talathi SS, Hwang DU, Ditto W. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Chapter 19, Ed: Osorio I. Int. Seizure Prediction Conf. Proceedings, pages 64-79, 2012. Carney PR, Talathi SS, Hwang DU, Ditto W. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Chapter 19, Ed: Osorio I. Int. Seizure Prediction Conf. Proceedings, pages 178-194, 2012. Barish P, Kantorovich S, Carney PR, Ogle W. Decoding Neural Circuitry with Optogenetics: Applications for Epilepsy. In: From the Hallowed Halls of Herpes virology – A Tribute to Bernard Roizman. Eds: John A. Blaho and Joel D. Baines, Editors World Scientific Publishing / Imperial College Press, pages 47-61, 2010. Fisher N, Talathi S, Cadotte A, Meyers, S, Carney PR. Epilepsy Detection and Monitoring, In: Quantitative EEG Analysis Methods and the Application. Eds: Shanbao Tong and Nitish V. Thakor, Artech House, Inc., of Norwood, MA, USA, pages 141-167, 2009. Carney PR, Cadotte A+, DeMarse TB, Vemuri B, Mareci T, Ditto W. Effective and anatomical connectivity in a rat model of spontaneous limbic seizures. In: Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Application. Wiley Vch Verlag GmbH & Co. KGaAA, Schelter B, Timmer J, Schultze-Bonhage A, Eds, 45-59, 2008. Chaovalitwongse W*, Pardalos PM, Iasemidis LD, Suharitdamrong DS*, Dance L+, Prokopyev OA*, Boginski VL,* Carney PR, Sackellares JC. Data mining in EEG: applications to epileptic brain disorders. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications. Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:459: 2007. Shiau DS+, Iasemidis LD, Yang MCK, Pardalos PM, Carney PR, Dance L+, Chaovalitwongse W*, Sackellares JC. Automated seizure prediction algorithm and its statistical assessment: a report from ten patients. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:517:2007. Nair SP*, Shiau DS+, Iasemidis LD, Norman WM+, Pardalos PM, Sackellares JC, Carney PR. Seizure predictability in an experimental model of epilepsy. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:535:2007. Prokopyev OA*, Boginski VL*, Chaovalitwongse W*, Pardalos PM, Sackellares JC, Carney PR. Network-based techniques in EEG data analysis and epileptic modeling. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:559:2007. Sackellares JC, Iasemidis LD, Shiau LD+, Pardalos PM, Carney PR. Spatiotemporal transitions in temporal lobe epilepsy. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 223-38.

Paul R. Carney, MD 26 Curriculum Vitae September, 2020

Shiau DS+, Chaovalitwongse W*, Iasemidis LD, Pardalos PM, Carney PR, Sackellares JC. Nonlinear dynamical and statistical approaches to investigate dynamical transitions before epileptic seizures. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 239-50. Yang MCK, Shiau DS+, Sackellares JC, Carney PR. Testing whether a prediction scheme is better than guess. Pardalos PM, Sackellares JC, Carney PR., and Iasemidis LD (Eds). In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 251-259. Carney PR, Shiau DS+, Pardalos PM, Iasemidis LD, Chaovalitwongse W*, Sackellares JC. Nonlinear neurodynamical features in an animal model of generalized epilepsy. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers, 2004, 37-52. Carney PR, Korhman MH. Relation between epilepsy and sleep during infancy and childhood. In: Sleep and Epilepsy: The Clinical Spectrum. Eds. Malow BM, Bazil C, Sammaritano M. Pub. Elsevier Science, pages 359-372, 2002. Carney PR, Paige P. Neurologic Disorders. In: Handbook of Neonatal Intensive Care. Eds. Merenstein, GB, Gardner SL. Pub. Mosby, 5th ed. 2001; 644-678 Poston MR,* Fredieu J,*, Carney P,* Silver J. The role of glia and neural crest cells in creating axon pathways and boundaries in the vertebrate central and peripheral nervous systems. In: The Making of the Nervous System. Oxford University Press, Parnavelas JG, Stern CD, Stirling RV, Eds, pages 282-313, 1986. Refereed Conference Presentations and Abstracts Gu B, Zhu M, Glass R, Rougie, Nikolova VD, Sheryl S. Moy SS, Carney PR, Philpot BD. Cannabidiol attenuates seizures and EEG abnormality in Angelman syndrome model mice. ASF annual meeting, 2019 DeMarse T, Cohen T, Carney PR, Meeker RB. Inflammation-associated release of MMP-9 increases neuronal vulnerability in an in vitro model of early Alzheimer pathogenesis. Society of Neuroscience Annual Meeting, 2018, 65816. Breskin G, Carney PR, Marcus RC, Tennison MB. Protein-losing enteropathy in a patient with quadriplegic cerebral palsy after long-term use of the ketogenic diet. American Epilepsy Society Annual Meeting, 2018. Jiang H, Carney PR. Non-Invasive Wearable Photoacoustic Tomography for Imaging Hemodynamics in Freely Moving Rats. 1570095989, OECC 2015 in Shanghai, China. Zhou J, Wang, D, Carney P. Acute amygdala seizures suppressed by halorhodopsin activation in vivo. American Epilepsy Society Annual Meeting, 2015, 2.119. Liu X, Carney P, Bussing R. Segal, L. Cottler, Winterstein A. Psychotropic drug utilization in children with epilepsy in 29 US states from 1999 to 2010. American Epilepsy Society Annual Meeting, 2015, 1.265. Fisher C, Astary G, Stewart R, Peprah M, Mareci T, Meisel M, Carney PR, Sarntinoranont M, Manuel M. Brain Matched Magnetic Susceptibility in Metallic Alloys for Use during MR Imaging. 2013 TMS Annual Meeting & Exhibition.

Paul R. Carney, MD 27 Curriculum Vitae September, 2020

Magdoom KN, Delgado F, Mahbub H, Carney PR, Sarntinoranont M. Understanding Transport of Nanoparticle-Drug Construct Following Fast Local Infusion in the Rat Brain: A MRI-based Computational Model. ASME (Boston, Mass), Feb 2013. Sarntinoranont M, Carney PR, Mareci TM. MR-Based Biotransport Models of the Brain and Solid Tumors. Society for Brain Mapping and Therapeutics, Baltimore, May 12-14, 2013. Shivakeshavan RG, Stefanescu RA, Khargonekar PP, Carney PR, Talathi SS. Effects of light stimulation on interictal spikes from ChR2 expressed CA1 pyramidal cells. SPIE BiOS, 2013. Stanley D, Talathi, SS, Carney PR. A local phase shift in hippocampal circadian rhythms during epilepsy. International Conference on Computational Biomedicine. Gainesville, FL 2012. Geyer JD, Carney PR. The relationship between temporal lobe epilepsy and restless legs syndrome. American Epilepsy Society Annual Meeting. 2012. Stefanescu, S, Khargonekar P, Talathi, S, Ratnadura, S, Carney PR. Computational Modeling of Light Activated Ion Channels. CNS Annual Meeting 2012. Astary, GW, Kantorovich S, Munson JW, S. J. Lee, SJ, Carney PR, Sarntinoranont, M, and Mareci. TH. MR. Relaxivity of Gd-DTPA-HSA in Brain Tissue: Towards Quantification of Tissue. Biomedical Engineering Society Annual Meeting 2012. Astary GW, Peprah MK, Fisher C, Carney PR, Sarntinoranont M. Meisel W, Manuel M, Mareci TH. Method for Magnetic Susceptibility Adjustment of Metal Alloys and Characterization with MRI. Biomedical Engineering Society Annual Meeting 2012. Sarntinoranont M, Carney PR, Mareci, TH. Convection-Enhanced Delivery of the Treatment of Epilepsy. First CSF Hydrodynamics Symposium. July 8 & 9, 2011. Zurich, Switzerland. Stanley DA, Talathi SS, Ni X, Huang L, Lai YC, Ditto WL, Carney PR. Circadian rhythms of gamma oscillations following status epilepticus: Implications for cognition. American Epilepsy Society Annual Meeting 2011. Ji J, Jiang H, Carney PR. Optogenetics: Novel Methods and Innovative Uses. Nanosymposium, Society for Neuroscience Annual Meeting, Wash D.C. 2011. Stanley DA, Carney PR, Parekh M, Mareci, TH, Talathi, SS, Ditto WL. Phase shift in hippocampal circadian rhythm during the latent period of epileptic rats. P-76. Organization for Computational Neuroscience Annual Meeting, Stockholm, Sweden. July 23-28, 2011. Boykin ER, Ogle, WO, Carney PR, Khargonekar, PP, Talathi SS. The applicability of effective connectivity measures to time series of neuronal oscillators. P-324. Organization for Computational Neuroscience Annual Meeting, Stockholm, Sweden. July 23-28, 2011. Ratnadura SR, Khargonekar PP, Carney PR, Talathi SS. Model parameter estimation for Channelrhodopsin-2 light gated ion channels. P-325. Organization for Computational Neuroscience Annual Meeting, Stockholm, Sweden. 2011. Stanley DA, Parekh MB, Carney PR, Ditto WL, Mareci TR, Talathi SS. Fimbria loss and its effect on circadian rhythms in epilepsy. Society for Neuroscience Annual Meeting, Baltimore, MD, Nov 2011. Astary GW, Kantorovich S, Carney PR, Sarntinoranont M, Mareci TH. Gd-albumin relaxivity in the rat thalamus at 11.1T. ISMRM Annual Meeting. 2011.

Paul R. Carney, MD 28 Curriculum Vitae September, 2020

Cadotte A, Parekh M, Triplett W, Talathi S, Mareci T, Carney PR. Integration of structure, behavior, and function for temporal lobe epilepsy: Evidence for future directions for exploration of ictogenic and epileptogenic transitions. American Clinical Neurophysiology Society Annual Meeting San Diego, CA, Poster and Abstract B109. 2010. Ratnadura S, Talathi SS, Carney PR, Khargonekar PP. Synchronization induced by signal propagation delays in inhibitory networks. Nineteenth Annual Computational Neuroscience Meeting San Antonio, Texas. 2010. Talathi SS, Ratnadura S, Kantorovich S, Carney PR, Khargonekar PP. Control of neural synchrony with light-activated opsins. Nineteenth Annual Computational Neuroscience San Antonio, Texas. 2010. Kim JH, Astary G, Kantorovich S, Mareci TH, Carney PR, Sarntinoranont M. Measurement of Vivo Tracer Distribution during CED in the Rat Brain using DCE-MRI. In: 37th Annual Mtg and Expo of the Controlled Release Society, Portland, OR, July 10-14, 2010. Colon-Perez L, Triplett W, Eisenscheck S, Carney PR, Mareci TH. Fiber tracking the cingulum in the human brain using a novel statistical model of water diffusion measured with MRI. University of Florida College of Medicine Research Day. April 24, 2010. Parekh M, Triplett W, Carney PR, Mareci TH. White Matter Reorganization in a Rat Model of Temporal Lobe Epilepsy Observed using Enhanced MRI. University of Florida College of Medicine Research Day. April 24, 2010. Astary G, Kantorovich S, Kim, JH, Lee SJ, Nobrega T, Parekh M, Triplett W, Carney PR, Mareci TH, Sarntinoranont M. Convection-Enhanced Delivery for the Potential Delivery of Therapeutic Agents for the Treatment of Epilepsy. University of Florida College of Medicine Research Day April 24, 2010. Kantorovich S, Barish P, Talathi SS, Ratnadura S, Zhou J, Myers S, Ogle W, Khargonekar PP, Carney PR. Control of hippocampal neural activity using optical stimulation. University of Florida College of Medicine Research Day. April 24, 2010. Allen H, Lee K, Jones L, Andrade E, Carney PR, Liu Z, Borum P. Ketogenic Therapy Education Modules for Caregivers and Healthcare Professionals. Experimental Biology 2010. Kantorovich S, Astary G, Parekh MB, Mareci TH, Sarntinoranont M, Carney PR. Status epilepticus affects hippocampal structure and infusate distribution profiles. Neuroscience. San Diego CA, November 13-17th, 2010. Cadotte A, Myers S, Parekh M, Talathi SS, Mareci T, Carney PR. Slow changes during epileptogenesis in a spontaneously seizing animal model of temporal lobe epilepsy. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010. Talathi SS, Zhao J, Cadotte A, Carney PR. Circadian rhythm of core body temperature in an animal model of chronic epilepsy. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010. Yuan Z, R. Jiang R, Ji L, Zhou J, Carney PR, Jiang H. Combining Granger causality and diffuse optical tomography to investigate the effective connectivity in temporal lobe epilepsy. Poster No. 3.235. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010.

Paul R. Carney, MD 29 Curriculum Vitae September, 2020

Zhang, Q, Hu Z, Yuan B, Zhou J, Carney PR, Jiang H. High temporal resolution photoacoustic imaging for seizure localization and network mapping. Poster No. 3.172 American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010. Jiang Q, Ji LZ, Zhou J, Carney PR, Jiang H. Noninvasive imaging of epilepsy using fast diffuse optical tomography. Poster No. 3.157. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010. Andrade E, Liu Z, Eisenscheck S, Cibula, SJ, Goldsmith I, Parekh M, Triplett W, Cadotte A, Mareci T, Carney PR. 3T Brian MRI and Ictal Findings of patients with nonlesional partial epilepsy refractory to medical treatment. American Epilepsy Society 64th Annual Meeting Dec 3- 7, 2010. Cadotte A, Myers S, Parekh M, Talathi SS, Mareci, TH, Carney PR. Slow changes in functional connectivity during epileptogenesis in a spontaneously seizing animal model of temporal lobe epilepsy. 1.056 American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010. Talathi SS, Carney PR, Khargonekar PP. In-phase neural synchrony through optical stimulation. Poster No. 44.10/H38. Neuroscience. San Diego, CA: Society for Neuroscience, 2010. Twyford P. DeMarse T, Barish P, Ogle W, Carney PR. Spatiotemporally precise optical system for controlling neural activity in vitro. Poster No. 816.1/NNN22. 2010 Neuroscience San Diego, CA: Society for Neuroscience, 2010. Kantorovich, S, Astary GW, Parekh M, Mareci TH, Sarntinoranont M, Carney PR. Convection enhanced delivery as a local anticonvulsant delivery method for the treatment of epilepsy. Society for Neuroscience Annual Meeting, Chicago, 2009. Zafar R, King MA, Frazier CJ, Carney PR. Adeno-associated viral vector delivered somatostatin as a neuroprotective agent for temporal lobe epilepsy. Society for Neuroscience Annual Meeting, Chicago, 2009. Parekh MB, Triplett WT, King MA, Mareci TH, Carney PR. Early damage in the parahippocampal gyrus after status epilepticus as a structural signature for the development of spontaneous seizures-a longitudinal study using enhanced MRI. Society for Neuroscience Annual Meeting, Chicago, 2009. Talathi SS, Hwang DU, Ditto WL, Carney PR. Circadian control of neural excitability in an animal model of temporal lobe epilepsy. 61st Annual Meeting of the American Academy of Neurology, 2009. Talathi SS, Hwang DU, Miliotis A, Carney PR, Ditto WL. Synchrony with Shunting Inhibition. Eighteenth Annual Computational Neuroscience Meeting CNS 2009. Astary GW, Kantorovich S, Parekh MB, Triplett WT, Carney PR, Mareci TH, Sarntinoranont M. Regional convention-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo. BMES, 2009. Myers S, Talathi S, Carney PR. Determining the firing rate of interictal population spikes leading to seizures. 2.102, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009. Zhou J, Talathi SS, Cadotte A, Liu Z, Holmes G, Carney PR. The effects of hippocampus CA1 single neuron firing properties on interictal spike patterns during onset in a rat model of temporal lobe epilepsy. 3.330, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009.

Paul R. Carney, MD 30 Curriculum Vitae September, 2020

Talathi SS, Nandan M, Ditto W, Khargonekar P, Carney PR. Support vector machine algorithms for early seizure detection in an animal model of temporal lobe epilepsy. 3.242, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009. Cadotte A, Talathi SS, Zhou J, Myers S, Hwang D, Ditto W, Carney PR. Analysis of hippocampal interdependencies for early seizure detection. 3.067, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009. Sarntinoranont, M, Kim JH, Carney PR, Mareci TH. Diffusion Tensor Imaging- based Computational Models of Convection-Enhanced Delivery. 6th Annual World Congress of the International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS), Boston, MA, August 26-29, 2009. Astary GW, Kantorovich S., Parekh MB, Carney PR, Mareci TH Sarntinoranont M. Convection Enhanced Delivery of an MR Contrast Agent to the Dorsal and Ventral Hippocampus. 2009 BMES Annual Meeting, Pittsburgh, PA, October 7-10, 2009. Carney PR, Cadotte AJ, Ditto WL, Mareci T, DeMarse TB, Temporal Lobe Epilepsy: Anatomical and Effective Connectivity, Conference on Computational Neuroscience Gainesville, FL. 2008. Cadotte AJ, DeMarse TB, Ditto WL, Carney PR. Granger Causality Analysis of Spontaneous Seizure in an Animal Model of Temporal Lobe Epilepsy, Pediatric Science Days, University of Florida Gainesville, FL. 2008. Cadotte AJ, DeMarse TB, Mareci T, Talathi SS, Hwang DU, Ditto W, Carney PR. Granger Causality Analysis of Spontaneous Seizure in an Animal Model of Temporal Lobe Epilepsy, Gordon Research Conference- Mechanisms of Epilepsy and Synchronization Waterville, ME. August, 2008. Talathi SS, Dong-Uk Hwang, Ditto WL, Spano ML, Sepulveda H, Mareci T, Carney PR. Chronobiology of epilepsy, Nature, 2008.1679.1, 2008. Talathi SS, Dong-Uk Hwang, Ditto W, Carney PR. Loss of balance and circadian phase reversal in an animal model of limbic epilepsy, IEEE BMES, St Louis. 2008. Dong-Uk Hwang, Talathi SS, Winters J, Ditto W, Carney PR. Controlling firing activity of population spikes during epileptogenesis in an animal model of temporal lobe epilepsy, IEEE BMES, St Louis. 2008. Geyer JD, Carney PR. The association between acute cerebral infarction and restless legs. American Academy of Neurology 60th Annual Meeting, Chicago, April 12-19, Scientific Abstract Number 1548, Poster number P05.170. 2008. Kumar R, Barmpoutis A, Vemuri BC, Carney PR, Mareci TH. Multi-fiber reconstruction from DW-MRI using a continuous mixture of von misses-fisher distributions. IEEE Conf. on Mathematical Methods for Biomedical Image Analysis. June 2008. Zafar R, Carney PR. Gene therapy for temporal lobe epilepsy: the role of adeno-associated viral vector delivered s Carney PR. Somatostatin. Society for Neuroscience Annual Meeting, Platform, Wash D.C. 2008. Cadotte A, DeMarse T, Carney PR. Analysis of spontaneous temporal lobe seizures using granger causality. Society for Neuroscience Annual Meeting, Platform, Wash D.C. 2008.

Paul R. Carney, MD 31 Curriculum Vitae September, 2020

Parekh MB, Sepulveda, Hoang King M, Mareci T, Carney PR. Diffusion tensor MR imaging of a rat model of temporal lobe epilepsy. 38th Annual Meeting, Society for Neuroscience 15-19 Nov 2008. Zafar R, Carney PR. Adeno associated viral vector delivered somatostatin as a candidate for gene therapy for temporal lobe epilepsy. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, Platform Session #: A.08. Dec. 2008. Cadotte A, DeMarse T, Ditto W, Carney PR. In vivo causal analysis of initiation, propagation and termination of spontaneous temporal lobe seizure. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, Platform Session #: A.03. Dec. 2008. Talathi SS, Hwang DU, Cadotte A, Ditto WL, Carney PR. Imbalance in hippocampal network synchrony during epileptogenesis. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, Poster Session IW. O3. Dec. 2008. Hwang Dong-Uk, Talathi S, Carney PR, Ditto W, Myers S, Norman W, Simonotto J. High frequency oscillations in the limbic rat model of temporal lobe epilepsy, J. Computational Neuroscience, 2007. Bing J, Vemuri BC, Ozarslan E, Carney PR, Mareci T A novel tensor distribution for the diffusion weighted MR signal. IEEE International Symposium on Biomedical Imaging: From Nano to Macro. April 12-17, 2007. Talathi SS, Carney PR, Dong-Uk Hwang, Ditto W, Myers S, Simonotto J. High frequency oscillations in rat model of chronic limbic epilepsy, CNS, Toronto, Canada, July 2007. Singh T, Little LE, Nathoo S, Snively C, Ringdahl D, Winger K, Jackson C, Carney PR, Liu Z, Borum P. Evaluating potential growth abnormalities in a patient population. Annual Meetings of the American Epilepsy Society and Canadian League against Epilepsy, 2006. Snively C, Carney PR, Liu Z, Ringdahl D, Winger K, Jackson C, Singh T, Little LE, Borum PR. Developing an Evidence-Based Ketogenic Therapy Program for Treatment of Epilepsy. Annual Meetings of the American Epilepsy Society and Canadian League against Epilepsy, 2006. Sepulveda H, Hoang-Minh L, Parekh MB, Hadlock A, Norman W, Sanchez JC, Ditto WL, Carney PR, Mareci T. Evolution of Temporal Lobe Epilepsy Observed with 11.1 Tesla MRI In Vivo. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Parekh M, Hoang-Minh LB, Sepulveda H, Haddock A, Norman W, Sanchez JC, Ditto WL, Carney PR, Mareci TH. Diffusion Tensor MR Imaging of the Rat Model of Mesial Temporal Lobe Epilepsy. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Nair SP, Norman WM, Dance L, Pardalos PM, Principe J, Carney PR. Development of Spatiotemporal Dynamical Transitions during Epileptogenesis. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Zhang Q, Zhao Z, Liu, Carney PR, Jiang H. Imaging of Seizure-Onset Zone with Non-Invasive Photoacoustic Tomography in a Rat Model of Focal Seizures. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Hoang-Minh L, Sepulveda H, Parekh M, Hadlock A, Norman W, Sanchez JC, Ditto WL, King MA, Carney PR, Liu Z, Mareci T. MRI Measurements at 17.6 Tesla in an Animal Model of

Paul R. Carney, MD 32 Curriculum Vitae September, 2020

Mesial Temporal Lobe Epilepsy Correlated with Histological Analysis. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors in Children with Epilepsy and Co-Morbid Sleep Disordered Breathing. Journal of the International Neuropsychological Society. 12(S1): 109. 2006. Geyer JD, Carney PR, Dillard SC. Epilepsy and Restless Legs Syndrome. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Martynyuk, AE, Carney PR, Dennis DM, Laipis PJ. Mechanisms of Epileptic Activity in Phenylketonuria: Decreasing Levels of Phenylalanine Trigger Seizures. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Loomis-Roux AR, Smith-Bonahue T, Carney PR. School Adjustment in Children with Epilepsy: Examining Parent Perceptions. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Sanchez JC, Liu Z, Carney PR. Identifying the seizure onset zone using amplitude modulated slow potentials, gamma, fast gamma, and neural ensemble activity. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006. Geyer JD, Carney PR, Dillard SC, Parrish P. Anti-depressant Medications, Neuroleptics and Prominent Eye Movements During. Sleep, Vol 29 Abstract Suppl. p. A34. 2006. Zhang QZ, Liu Z, Carney PR, Jiang HB, Imaging epilepsy using finite-based photoacoustic tomography: Initial in vivo results. Optical Society America Annual Meeting, Lauderdale, FL 2006. Singh, T, Little, LE, Nathoo S, Carney PR, Borum PB. Evaluating potential growth abnormalities in a patient population at Shands/UF on ketogenic therapy for seizures. Experimental Biology Meeting, 2006. Sanchez JC, Gunduz A, Carney PR, Principe JC. Extraction and localization of mesoscopic motor control signals for human ECoG neuroprosthetics. Neuroplasticity Conference, 2006. Sanchez JC, Principe JC, Carney PR. Choosing the Appropriate Level of Abstraction for Brain Machine Interfaces: Data Collection and Analysis Insights. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-17, 2006. Carney PR. Dynamical EEG Properties in the Limbic Epilepsy Rat Model. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-17, 2006. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors in Children with Epilepsy and Co-morbid Sleep Disordered Breathing, International Neuropsychological Society, Boston, MA, Feb. 3-6, 2006. 2(S1): 109, 2006. Shiau DS, Sackellares JC, Iasemidis LD, Nair SP, Norman W, Carney PR. Automated Seizure Warning in an Epileptic Rat Model. 57th Annual Meeting of the American Academy of Neurology, Miami FL, April 2005. Neurology 64 Suppl. 1 (Abs. A: 266), 2005. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Muscle and Nerve, 57th Annual Meeting of the American Academy of Neurology, April 2005.

Paul R. Carney, MD 33 Curriculum Vitae September, 2020

Shiau DS, Iasemidis LD, Sackellares JC, Suharitdamrong W, Shenk D, Carney PR. Quantitative methods for distinguishing neonates at risk for seizures from normal newborns. Pediatric Academic Society 2005: 57: 2655. Furman M, Ditto W, Simonotto J, Carney PR. High-Resolution Phase Tracking of Moving Epileptic Foci with Phase-Dynamic Quantification Analysis. Epilepsia 46 Suppl. 8:314 (Abs. 3.113), 2005. Liu Z, Norman W, Shenk D, Carney PR. Similarity of electroencephalographic changes in a rat model of human temporal lobe epilepsy. Epilepsia 46 (8): 292. 2005. Bongiolatti S, Fennell E, Carney PR. Sleepiness as a Factor in Varying Degrees of Behavior Problems in Children with Epilepsy. Epilepsia 46 Suppl. 8:75 (Abs. 1.176) 2005. Simonotto J, Furman, Norman W, Sanchez J, Ditto W, Carney PR. Nonlinear Analysis of High- Resolution Microwire Electrode Data from a Chronic Limbic Epilepsy Model over the Latent Period. Epilepsia 46 Suppl. 8:124(Abst.2.098), 2005. Nair S, Shiau D, Pardalos PD, Iasemidis L, Sackellares JC, Carney PR. Dynamical Responses to Hippocampal Stimulation in a Rodent Model of Chronic Limbic Epilepsy. Epilepsia 46 Suppl. 8:332 Abs. 3.163, 2005. Sanchez J, Norman W, Mareci T, Carney PR. Multiscale Electrophysiological analysis and imaging in an animal model of limbic epilepsy. Epilepsia 46 Suppl. 8:10, 2005. Geyer JD, Carney PR, Gilliam F. Focal Dyshormia: Focal epileptiform spikes in conjunction with K-complexes. Epilepsia 46 Suppl. 8:27 (Abs. 1.041), 2005. Shiau DS, Liu C, Suharitdamrong W, Pardalos PM, Carney PR, Sackellares JC. Distinguishing independent bitemporal form unilateral onset in epileptic patients by the analysis of nonlinear characteristics of EEG signals. Epilepsia 46 Suppl. 8:321 (Abs. 3.131), 2005. Carney PR, Nair SP, Iasemidis LD, Shiau DS, Pardalos PM, Shenk D, Norman WM, Sackellares JC. Quantitative analysis of EEG in the rat limbic epilepsy model. American Academy of Neurology 56th Annual Meeting, San Francisco, April 24-May 1, Poster P04.016, 2004. Sackellares JC, Iasemidis LD, Shiau DS, Yang CK, Dance LD, Pardalos PM, Carney PR. Automated seizure warning system performance in temporal lobe epilepsy. American Academy of Neurology, 56th Annual Meeting, San Francisco, April 24-May 1, Poster P02.033, 2004. Nair SP, Shiau DS, Norman WN, Shenk D, Suharitdamrong W, Iasemidis LD, Pardalos PM, Sackellares JC, Carney PR. Dynamical changes in the rat chronic limbic epilepsy model. Epilepsia 45 Suppl. 7:211 (Abs. 2.060), 2004. Shiau DS, Iasemidis LD, Yang MCK, Carney PR, Pardalos PM, Suharitdamrong W, Nair SP, Sackellares JC. Pattern-match regularity statistics-a measure quantifying the characteristics of epileptic seizures. Epilepsia 45 Suppl. 7:85 (Abs. 1.213), 2004. Furman, Michael, Sackellares. J Chris, Carney PR, Miliotis, Abraham, Simonotto, Jennifer, Ditto, William. Phase Tracking of Moving Epileptic Foci Using EEG and Phase-Dynamic Quantification Analysis. American Physical Society, March Meeting abstract #V8.008. 2004. Shiau DS, Iasemidis LD, Sackellares JC, Pardalos PM, Carney PR, Chaovalitwongse W. Nonlinear Dynamics and Global Optimization Approaches to Investigate Dynamical Transitions

Paul R. Carney, MD 34 Curriculum Vitae September, 2020

Before and After Epileptic Seizures. Quantitative Neurosciences Conference at University of Florida, Feb 2003. Sackellares JC, Iasemidis LD, Shiau DS, Carney PR, Pardalos PM, Chaowolitwongse W, Preictal Transition in Temporal Lobe Epilepsy. Quantitative Neurosciences Conference at University of Florida, Feb 2003. Carney PR, Iasemidis LD, Sackellares JC, Srivastava A, Shiau DS, Maze MF, Zhang L, MacLennan AJ, Pardalos PM. Seizure Prediction by Nonlinear Times Series Analyses of Brain Electrical Activity in the H218 Animal Model. Quantitative Neurosciences Conference at University of Florida, Feb 2003. Iasemidis LD, Sackellares JC, Pardalos PM, Shiau DS, Chaovalitwongse W, Carney PR. Epileptic Seizure Prediction. Quantitative Neurosciences Conference at University of Florida, Feb 2003. Chaovalitwongse W, Pardalos PM, Sackellares JC, Iasemidis LD, Shiau DS, Carney PR. Nonlinear Dynamics and Global Optimization in EEG with Applications for Prediction of Epileptic Seizures. Quantitative Neurosciences Conference at University of Florida, February, 2003. Sackellares JC, Shiau DS, Pardalos PM, Carney PR, Chaowolitwongse W. Time Irreversibility of Brain Spatiotemporal Dynamics at Epileptic Seizure Transitions. International Nonlinear Sciences Conference, Vienna, Austria, February 7-9, 2003. Sackellares JC, Yang MCK, Iasemidis LD, Shiau DS, Pardalos PM, Carney PR. Real Time Prospective Seizure Prediction and Statistical Assessment. NIH Biomedical Information Science Technology Initiative Consortium BISTIC, Bethesda, MD, Nov 6-7, 2003. Shiau DS, Sackellares JC, Iasemidis LD, Carney PR, Pardalos PM, Chaovalitwongse W. Dynamical Entrainment Among Epileptic Brain Areas, Ann Neurol. 2003; 54 (S7: S55) Sackellares JC, Iasemidis LD, Shiau DS, Suharitdamrong W, Dance LK, Chaovalitwongse W, Pardalos PM, Carney PR. An Automated Seizure Warning Algorithm for Scalp EEG. Epilepsia; 44 (9), 228. 2003. Carney PR, Sackellares JC, Shiau DS, Iasemidis LD, Chaovalitwongse W, Suharitdamrong W, Pardalos PM. Detection of Seizures in Newborns by Quantitative EEG Signal Analyses. Epilepsia 44 (9) 54-55. 2003. Sackellares JC, Yang MCK, Shiau DS, Iasemidis LD, Pardalos PM, Carney PR. Prospective controlled trial of an automatic seizure prediction algorithm. American Academy of Neurology 55th Annual Meeting, 2003. Neurology 60 Suppl. 1, Number 5, 2003. Saxonhouse MA, Bhatti MT, Driebe WT, Freeman BE, Maria BL, Carney PR. Primary antiphospholipid syndrome presenting with a branch retinal artery occlusion in a 15-year-old boy. J Child Neurol.17(5): 392-4. 2002. Sackellares JC, Shiau DS, Iasemidis L, Pardalos P, Chaovalitwongse W, Carney PR. Can knowledge of cortical site dynamics in a preceding seizure be used to improve prediction of the next seizure? Annals Neurol. 52 (3S), S65-S66. 2002. Carney PR, Maze MF, Shiau DS, Srivastava A, Iasemidis LD, Pardalos PM, Sackellares, JC. State-specific nonlinear neurodynamic features in an animal model of generalized epilepsy. Epilepsia 43 Suppl. 7:270 (Abs. 3.063), 2002.

Paul R. Carney, MD 35 Curriculum Vitae September, 2020

Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear Approximate Entropy Analysis of Brain Electrical Activity in a Generalized Epilepsy Animal Model. Epilepsia 443 (7): 27. 2002. Iasemidis LD, Shiau DS, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares JC. Adaptive Seizure Prediction System. Epilepsia 43 Suppl. 7:264 (Abs. 3.048), 2002. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau, DS, Pardalos PM, Carney PR, Sackellares JC. Seizure Prediction by Dynamical Phase Information from the EEG. Epilepsia 43 Suppl. 7:45 (Abst.1.121), 2002. Snively C, McLennan CS, Maze MF, Carney PR. Efficacy and tolerability of the ketogenic diet in the very young. Epilepsia 43 Suppl. 7:225 (Abs. 2.281), 2002. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau DS, Pardalos, PM, Carney PR, Sackellares JC. Seizure prediction by dynamic phase information from the EEG. Epilepsia 443(7): 45. 2002. Sackellares JC, Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney PR. Dynamic dependence of seizure prediction on preceding seizures. Epilepsia 43, Suppl. 7:50 (Abs. 1.136), 2002. Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares JC. Adaptive seizure-prediction system. Epilepsia 443(7): 264. 2002. Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear approximate entropy analysis of brain electrical activity in a generalized epilepsy animal model. Epilepsia 443(7): 273. 2002. Muir A, Carney PR. Epilepsia partialis in a ketoacidotic child. Ann Neurol. 1999; 46:96. Tran TX, Palmer SC, Ni O, Iasemidis LD, Pardalos PM, Srivastava A, Won J, Shiau DS, Lee N, MacLennan AJ, Sackellares JC, Carney PR. Predictability of seizures in an epilepsy-prone transgenic mouse model, Epilepsia; 42 (7): 225. 2001. Tran TX, Palmer SC, Ni OK, Muir AB, Carney PR. Epilepsia partialis continua as a presenting manifestation of diabetic ketoacidosis. Ann Neurol. 46: 96; 1999. Carney PR, Blaivas M, Drury I. Histopathological findings in a familial form of medically refractory temporal lobe epilepsy. Epilepsia 1998. Payne T, Kothary S, Varma N, Nasreddine W, Carney PR, Shu V, Beydoun A. Serum sodium and thyroid function after replacement of carbamazepine with oxcarbazepine. Epilepsia; 3.023. 1997. Carney PR, Nasreddine W, Drury I, Varma N, Payne T, Shu V, Beydoun A. The relationship between thrombocytopenia and valproate dose. Epilepsia; 3.054. 1997. Larson W, Carney P, Aldrich M. Atypical presentation of Leigh disease in a teenage woman. Mitochondrial Diseases Symposium. Indianapolis, Ind., 1995. Carney PR, Couve E. Cell polarity changes and migration during early development of the avian peripheral auditory system Fourth International Congress of Cell Biology (Montreal); 7.2.28. 1988. Carney PR, Silver J, Manubens L. Cell migration and axon guidance in the developing rat auditory system. 3rd Regional Chile Biol. Soc. 4:10. 1983.

Paul R. Carney, MD 36 Curriculum Vitae September, 2020

Carney PR, Silver J. A mechanism for the guidance of peripheral spiral ganglion cell axons in the developing mouse auditory system. Soc. Neurosci. XVI, 6:487. 1980. Intellectual Property US Patents Sanchez JC, Carney PR. Closed-Loop Micro-Control of Epileptic Neuronal Activity. US Patent: 8,374,696. February 12, 2013 Talathi SS, Hwang DU, Ditto WL, Carney PR, Spano M. Method and system for detecting epileptogenesis. US Patent: 8,447, 407. May 21, 2013 Mareci TH, Carney PR, Astary GW, Sepulveda H, Manuel VM, Fisher RC. Magnetic resonance compatible and susceptibility-matched apparatus and method for MR imaging and spectroscopy. US Patent: 20,120,133,363. 2012 Carney PR, Sackellares JC, Shiau D. Real-time brain monitoring system. Patent Number 7,433,732, October 7, 2008

Invention Patent Disclosures Sanchez JC, Carney PR. Closed-Loop Micro-Control System for Predicting and Preventing Epileptic Seizures. Patent UF#- 63815P (49163), 2005 Anderson C, Carney PR. Cannabinoids for the treatment of sleep dysfunction in neurological disorders Attorney Docket No.: AND-CAR-SLP18, 2018 Hochhaus G, Carney PR. Valproic Acid Derivative Compounds. UF3-13715, 2011 Talathi SS, Carney PR, Hwang DU Ditto WL. Detecting Epileptogenesis. Attorney Docket No.: 450-P0005US, 2010 Mareci TH, Carney PR, Astary GW, Sepulveda H. Magnetic Resonance Compatible and Susceptibility-Matched Apparatus and Method for MR Imaging and Spectroscopy. Application Number 61/232,288, 2009 Ogle W, Carney PR. Optically Active Opioid Receptors for the Treatment of Chronic/Acute Pain. Application Number 13317, 2009 Ditto, WL, Carney PR, Talathi S, Hwang, DU. Neuromodulation of Excitation and Inhibition to Control Epilepsy and Neurological Disorders. Invention disclosure UF # 12785 2008 Sackellares JC, Principe JC, Shiau DS, Pardalos PM, Carney PR, Cho J, Nair SP Suharitdamrong W, Dance LK. State Dependent, Direct and Model-based Closed-loop Seizure Control System. UF invention disclosure # – 11926, 2005 Sackellares JC, Carney PR, Shiau DS. Interactive Dynamical Brain Monitoring and Neuro Diagnostic Systems. Attorney Docket No. 028724-144.001United States Patent Application Number 11/065,703, 2004 Carney PR, MD, Sackellares JC, MD, Shiau D. Real-Time Brain Monitoring System. Patent UF#-11220, 2003 Sackellares JC, MD, Carney PR. Multi-Dimensional Multi-Parameter Time Series Processing for Seizure Warning & Prediction. Provisional Patent UF#-No 028724-143, 2003 Investigational New Drug License

Paul R. Carney, MD 37 Curriculum Vitae September, 2020

Carney, PR. Treatment of Drug Resistant Epilepsy. IND # 120055; Study NCT02461706, June 2, 2015 (Active) Research Grants/Projects Active Title: Neural network dysfunction in early HIV neuropathogenesis Agency: NIH R01NS108808-01 Role: P Carney (Co-PI), T. Cohen (Co-I). R. Meeker (Contact PI) Effort: 1.2 calendar months Award Period: 08/01/2018-07/31/23 Total Award: $1,943,750

Pending Title: Treatment of sleep disturbance in children with autism Agency National Institutes of Mental Health Role: P. Carney (Consultant), C. Johnson (MPI) Award Period: Notice of award pending

Completed Title: Effects of cannabidiol use on the developing brain in medically refractory childhood epilepsy Agency: Angelman Syndrome Foundation Role: P. Carney (Contact PI), B. Philpot (Co-PI), B. Gu (Co-I) Award Period: 07/01/2018 – 06/30/2019 Effort: 1.0 calendar Total Award: $200,000

Title: Preclinical imaging of adolescent cannabidiol brain structure and functional connectivity Agency: NIH R03 DA042971 Role: P. Carney (PI), M. Febo (PI) Award Period: 10/01/17 – 09/30/19 Effort: 1.0 calendar month Total Award: $150,000

Title: Bridging the childhood epilepsy treatment gap in norther Nigeria (BRIDGE) Agency: 5R21TW010899-02 Fogarty International Center Role: E. Trevathan (Contact PI), M. Aliyu Hassan (PI), P. Carney (Consultant) Award Period: 09/17/17 – 08/31/19 Total Award: $179,183

Title: 5EP01 Effects of cannabidiol use on the developing brain in medically refractory childhood epilepsy Agency: Florida Department of Health Role: P. Carney (Contact PI), C. Johnson (Co-I), T. DeMarse (Co-I), M. Febo (Co-I), I. Miller (Miami Children’s subcontract Co-I)

Paul R. Carney, MD 38 Curriculum Vitae September, 2020

Award Period: 06/04/2015 – 06/30/2018 Effort: 4.2 calendar months Total Award: $1,000,000

Title: Translational advancement of somatostatin gene delivery for disease modification and cognitive sparing in intractable epilepsy Agency: W81 XWH-13-1-0256 Department of Defense CDMPR Role: P. Carney (Co-PI), B. Omerod (Co-I), M. King (Contact PI) Award Period: 09/01/2013-08/31/2017 Effort: 3.0 calendar months Total Award: $1,430,804

Title: Direct functional imaging of electrical brain stimulation Agency: NIH R01NS077004-01 Role: P. Carney (Co-PI) T. Mareci (Co-PI), R. Sadlier (Contact PI) Award Period: 03/15/2014 – 06/30/2016 Effort: 1.2 calendar months Total Award: $2,028,216

Title: In vivo imaging of therapeutic electric current flow Agency: NIH R21NS081646-01 Role: P. Carney (Co-PI), T. Mareci (Co-I), R. Sadlier (Contact PI) Award Period: 07/01/2014 – 06/30/2016 Effort: 1.2 calendar months Total Award: $462,302

Title: SST gene delivery to enhance long-term functional recovery from TBI Agency: Department of Veterans Affairs, Rehabilitation R&D SPiRE grant Role: P. Carney (Co-PI). M. King (Contact PI) Award Period: 09/01/2014-08/31/2016 Total Award: $200,000

Title: Photoacoustic imaging of epilepsy Agency: PR080678 Department of Defense CDMRS Advanced Technology Therapeutic Development Award Role: P. Carney (Co-PI), H. Jiang (Contact PI) Award Period: 04/01/2009-03/31/2014 Effort: 1.8 calendar months Total Award: $1,490,551

Title: Noninvasive and cellular imaging of epilepsy Agency: NIH R01NS069848-04 Role: P. Carney (Co-PI), H. Jiang (Contact PI) Award Period: 02/15/2010-01/30/2015 Effort: 1.8 calendar months Total Award: $1,136,626

Title: Computational transport models for convection-enhanced CNS delivery

Paul R. Carney, MD 39 Curriculum Vitae September, 2020

Agency: NIH R01 NS063360 Role: P. Carney (Co-I), T. Mareci (Co-I), M. Sarntinoranont (Contact PI) Award Period: 09/29/2008-07/31/2014 Effort: 2.4 calendar months Total Award: $1,490,551

Title: Collaborative Research Computational Neuroscience (CRCNS): Evolution into epilepsy Agency: NIH R01-EB004752 Role: P. Carney (Co-PI), T. Demarse (Co-I), T. Mareci (Co-I), W. Ditto (Contact PI) Award Period: 09/01/04-06/30/10 Effort: 2.4 calendar months Total Award: $1,287,170

Title: Collaborative Research Computational Neuroscience (CRCNS): Automatic prediction of the onset of epilepsy via analysis of high angular resolution diffusion imaging (HARDI) Agency: NIH R01 EB007082 Role: P. Carney (Co-I), T. Mareci (Co-I) B. Vemuri (Contact PI) Award Period: 08/01/06- 05/31/10 Effort: 1.8 calendar months Total Award: $1,296,877

Title: Balanced polyvalent anti-glutamatergic action as a novel approach to efficacious neuroprotection Agency: NIH R21 NS060862 Role: P. Carney (Co-I), A. Martynyuk (Contact PI) Award Period: 09/15/08-06/30/10 Effort: 1.0 calendar month Total Award: $325,000

Title: On-line real-time seizure prediction Agency: NIH R01 NS050582 Role: J. Principe (Co-I), P. Pardalos (Co-I), L. Iasemidis (Co-I), P. Carney (Co- I), C. Sackellares (Contact PI) Award Period: 09/01/02-06/30/05 Effort: 3.0 calendar months Total Award: $2,382,724

Title: Bioengineering Research Partnership in Brain Dynamics Agency: NIH R01 EB002089 Role: P. Carney (Contact PI 2005-06), C. Sackellares (Co-PI), J. Principe (Co- PI), P. Pardalos (Co-PI), L. Iasemidis (Co-PI) Award Period: 07/19/01-04/30/07 Effort: 3.0 calendar months Total Award: $3,825,000

Paul R. Carney, MD 40 Curriculum Vitae September, 2020

Title: Dichloroacetate Kinetics, Metabolism and Toxicity Agency: NIH Role: P. Carney (Co-PI) P. Stacpoole (Contact PI) Award Period: 07/01/04-06/30/09 Effort: 1.0 calendar month Total Award: $1,800,000

Title: An EEG method for real-time detection of neonatal seizures in the NICU Agency: Epilepsy Foundation of America Partnership for Pediatric Epilepsy Research Role: P. Carney (Contact PI), D. Shaiu (Co-PI) Award Period: 05/01/03-04/30/06 Total Award: $75,000

Title: Outcome of Therapeutic Hypothermia in Pediatric Arrest Agency: NIH R21 HD 044981 Role: P. Carney (Co-I), Z. Zaritsky (Contact PI) Award Period: 06/30/03-07/01/06 Effort: 1.0 calendar Total Award: $290,000

Title: A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Stratified, Parallel-Group Trial of the use of Telecommunications in Evaluating Compliance in Teen Epilepsy Agency: NIH Dates: 09/01/98-10/30/03 Role: P. Carney (Co-I), R. Gluekhoff (Contact PI) Effort: 0.25 calendar month Total Award: $31,600 Sponsorship (Mentor) of Postdoctoral Fellowships Title: Goodman Trust Award 2011 Agency: Child Neurology Society Recipient: Phillip Chong Medical Student Dates: 06/15/11 to 08/15/11 (summer scholarship) Role: Medical student mentor Effort: 0.8 calendar cost share Total award: $2,500

Title: Goodman Trust Award 2010 Agency: Child Neurology Society Recipient: YJ Park Medical Student Dates: 6/1/2010 to 5/31/2011 Role: Medical student mentor Effort: 0.8 calendar cost share Total award: $2,500

Title: Subcortical Executive Function and Frontal Lobe Childhood Epilepsy

Paul R. Carney, MD 41 Curriculum Vitae September, 2020

Agency: Epilepsy Foundation of America Dates: 07/01/2004 to 6/30/2005 Role: Postdoctoral research mentor for Sachin Talathi, PhD Effort: 0.8 calendar cost share Total award: $40,000

Intramural Grants Title: Dissecting the effects of the host genetic background in phenotypes of Dravet syndrome collaborative cross pilot proposal Agency: University of North Carolina TraC Pilot Grant Role: P. Carney (Contact PI), T. Kafri (Co-PI) Award Period: 05/01/18-05/01/19 Total Award: $10,000

Title: Inflammation, aging and Alzheimer disease vulnerability Agency: UNC TraC Pilot Grant Role: T. Cohen (Co-PI), P. Carney (Co-PI), R. Meeker (Contact PI) Award Period: 07/01/17-06/30/18 Total Award: $100,000 Title: Control of Neural Synchrony with Light-Activated Opsins Working Group Agency: University of Florida Computational Biology Working Group Seed Grant Dates: 04/01/10 to 03/31/11 Role: Talathi (PI), Carney (PI), P. Khargonekar (Contact PI) Effort: 1.2 calendar months Amount: $100,000

Title: Novel Anti-Epileptic Drug Discovery: Somatostatin Receptor Modulation for Treating Epilepsy Agency: Research Opportunity Fund Competition University of Florida Dates: 09/01/04-06/30/06 Role: P. Carney (PI) Effort: 1.0 calendar month Amount: $100,000

Title: On-Line Real-Time Seizure Prediction in Adult Patients with Epilepsy Agency: Office of Technology Licensing, University of Florida Division of Sponsored Research Dates: 04/15/04-03/30/05 Role: P. Carney (Contact PI), C. Sackellares (Co-PI) Effort: 0.8 calendar month Amount: $26,872

Title: Dynamical on-line real-time seizure warning and treatment in an epilepsy- prone rodent model Agency: University of Florida Division of Sponsored Research Opportunity Fund Role: P. Carney (PI)

Paul R. Carney, MD 42 Curriculum Vitae September, 2020

Effort: 0.6 calendar month Dates: 07/01/01 – 06/30/02 Amount: $50,000

Title: Pre-ictal detection and seizure prevention in a transgenic mouse model of childhood epilepsy Agency: Children’s Miracle Network Dates: 06/30/01- 07/01/02 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $1,000

Title: Pediatric EEG/Sleep Agency: Children’s Miracle Network Grant # 2000-044 Role: P. Carney (PI) Dates: 05/01/00- 04/30/01 Effort: 0.5 calendar month Amount: $3,330

Title: In Vivo Neurophysiologic Characterization of the Epilepsy-Prone Sphingosine 1 Phosphate Receptor H218 Knockout Mouse Agency: Children’s Miracle Network Grant Role: P. Carney (PI) Effort: 0.5 calendar month Dates: 08/15/00- 07/01/01 Amount: $40,000

Title: Dynamical Studies in Generalized Childhood Epilepsy Agency: Biomedical Engineering Program Dates: 08/30/99- 06/30/00 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $25,000

Title: The Relationship between Sleep-Related Breathing Disorders and Hearing in Children Epilepsy Surgery Program Agency: Children’s Miracle Network Grant # 99S-035 Intramural Patient Dates: 09/01/99 – 06/30/00 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $16,700

Title: Sleep Disorders Center Agency: Children’s Miracle Network Grant # 99S-056 Dates: 09/15/99-06/30/00 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $7,500

Paul R. Carney, MD 43 Curriculum Vitae September, 2020

Title: Pediatric Epilepsy Program Agency: Children’s Miracle Network Grant # 98HS-001 Role: P. Carney (PI) Dates: 09/02/98-05/15/99 Effort: 0.5 calendar month Amount: $2,587

Title: Epilepsy Monitoring Program Agency: Children’s Miracle Network Grant # 98HF-015 Dates: 09/01/98-06/30/99 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $48,000

Industry Sponsored Grants Title: Investigator initiated study: Preclinical investigation of Epidiolex for autism spectrum disorder brain connectivity and behavior Agency: GW Pharma, Inc. Role: P. Carney (PI) Award Period: 02/15/17-08/01/18 Effort: 1.0 Calendar Total Award: $245,000 Title: Heart Rate Changes in Epilepsy E-30-S Agency: Cyberonics, Inc. Dates: 05/25/11-09/01/13 Role: P. Carney (PI) Effort: 0.5 calendar month Amount: $550,705

Title: Evaluation of the efficacy and tolerability of Levetiracetam add on treatment in refractory pediatric patients with partial onset seizures Funding Agency: GlaxoSmithKline Grant # LAM40013 Dates: 07/01/02-06/30/03 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $58,000

Title: A multicenter, open label conversion of valproate monotherapy to lamotrigine monotherapy in patients with epilepsy Funding Agency: GlaxoSmithKline Grant # LAM 40013 Dates: 06/15/02-06/30/04 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $77,000

Paul R. Carney, MD 44 Curriculum Vitae September, 2020

Title: A multi-center open label, pilot study of lamotrigine as adjunctive therapy and monotherapy in patients with epilepsy and co morbid depression Funding Agency: GlaxoSmithKline Grant # LAM40117 Dates: 05/30/02-06/30/03 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $37,000

Title: A multicenter, open-label study to investigate the pharmacokinetics of commercial lacosamide oral formulations as therapy in children SP1047 Agency: UCB Biosciences, Inc. Dates: 07/01/01-04/01/02 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $15,000

Title: A multi-center, double blind, randomized, placebo-controlled, parallel- group evaluation of lamotrigine adjunctive therapy in subjects with primary generalized tonic-clonic seizures Agency: Glaxo-Wellcome, Inc. Dates: 10/15/01-09/15/02 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $21,000

Title: In patient Rufinamide as adjunctive therapy Agency: Novartis, Inc. Dates: 06/15/00-04/30/01 Role: P. Carney (PI) Effort: 0.5 calendar month Total Award: $18,500

Title: Rufinamide as adjunctive therapy in children and adults with inadequately controlled partial seizures Agency: Novartis, Inc. Dates: 11/01/98-09/30/99 Role: P. Carney (PI) Effort: 0.8 calendar month Total Award: $41,800

Title: Ketogenic Eggnog versus Ketogatornog Treatment for Seizures Agency: Ross Foods, Inc. Dates: 10/01/98-06/01/01 Role: P. Borum (Contact PI), P. Carney (Co-PI) Effort: 0.25 calendar month Total award: $3,500 Presentations (Selected)

Paul R. Carney, MD 45 Curriculum Vitae September, 2020

University of Toledo Departments of Neurology and Neuroscience Grand Rounds. “Developmental and Epileptic Encephalopathies - An Evolving Landscape”. September 3, 2020 UMass Department of Pediatrics Grand Rounds. “Pediatric Epilepsy: New and Novel Approaches to Care”. May 8, 2020. CBD 2020 Conference, 12th Annual Chair Summit, Las Vegas. The Evidence Supporting CBD Use in Rare Neurologic Behavioral Disorders, February 26, 2020. Cleveland Clinic Foundation, Epilepsy Center, Invited Grand Rounds Speaker. “Defining and Modeling an Epileptic Network”, August 23, 2019. University of Alabama, Office of the VP for Research and Economic Development. Invited Speaker. “Envisioning the Future of the ALRI”. April 23, 2019 University of Alabama, Office of the Vice President for Research, Invited Speaker. “Advances in Epilepsy Genetics: Toward Better Treatments and Cures”. March 23, 2019

University of Missouri, Department of Pediatrics, Invited Speaker, “Neural network dysfunction in early epileptogenesis”. March 7, 2019 Duke University, Department of Pediatrics, Division of Immunology, Invited Speaker, “Neural Network Dysfunction in Early HIV Neuropathogenesis”. February 27, 2019 Carolina Institute for Developmental Disabilities, Invited Speaker, Endocannabinoids in Medicine, November 2017 Florida Pediatric Epilepsy Network 1st Annual Conference, Invited Speaker: “Cannabidiol in Pediatric Epilepsy and in Florida”, Orlando, Florida, June 9-11, 2016 University of Illinois, Department of Neurology and Rehabilitation, Grand Rounds, Invited Speaker: “Therapeutic Devices for Drug-Resistant Epilepsy”, May 28, 2015 NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Florida Symposium on the BRAIN Initiative, UF Brain Institute and Scripps Institute, Invited Speaker: “Mapping Brain Networks with Optical Imaging Tools”, January 17, 2014 13th Curso International de Neuropsiquiatria Infantile. Viña del Mar, Chile, Keynote speaker: “Mitos y Realidades en Autismo”, May 30-31, 2014 The Epileptic Brain Map, University of Chicago, Department of Pediatrics, November 15, 2013 Mapping the Epileptic Brain: Implications for Treatment and Repair, Rutgers University, Department of Neurology and Neuroscience, October 1, 2013 Neural Networks in Epilepsy 2013 Spring Physiological Sciences Seminar Series (VME 6932), University of Florida, March 26, 2013 UF 2013 Physiological Sciences Spring Seminar Series, Neural Networks. March 26, 2013 Distinguished Invited Honorary Speaker, Georgia Academy of Science, Neural Networks in Epilepsy: Evidence of and Implications for Treatment, March 29, 2013, Valdosta, GA Invited Speaker, UF MD/PhD Candidate Talk. A Neuroscientist’s Journey to Reverse Engineer the Human Brain. February 18, 2013 Neural Networks in Epilepsy: Evidence of and Implications for Treatment. UF Neuroscience Seminar Series GMS 7794, January 21, 2013

Paul R. Carney, MD 46 Curriculum Vitae September, 2020

Neural Networks in Epilepsy. University of Vermont, Burlington VT. November 12, 2012 Neural Networks in Epilepsy: Evidence of and Implications for Treatment. Saint Lois University, October 11, 2012 Epilepsy in the Presence of Sleep Disorders. Phoenix Children's Hospital/Barrows Neurological Institute, Phoenix, Arizona. August 2012 Noninvasive Functional and Cellular Imaging of Epilepsy. The Neurological Institute of New York Columbia University Medical Center, New York, November 21, 2011 Cleveland NEW Neural Engineering Workshop, June 16-17, 2011, Cleveland, Ohio Emerging Therapies in Epilepsy, American Pediatric Society Outstanding Invited Science by New Members Symposia, Denver, CO, May 1, 2011 5th International Seizure Prediction Workshop, Sept.19-23, 2011, Dresden, Germany Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Nocturnal Frontal Lobe Epilepsy: An Interdisciplinary Perspective. National Institutes of Health Office of Rare Diseases Research and Alliance for Epilepsy Research. Sanibel Symposium. Sanibel, FL, February 11-12, 2010 Optogenetics Deconstruction of Hippocampus Epileptic Neural Circuitry. American Clinical Neurophysiology Society, Annual Meeting San Diego, CA, Feb. 2-7, 2010 Curing Epilepsy: Progress and Future Directions, Grand Rounds, Medical College of Milwaukee, Milwaukee, WI, December 13, 2010 Epilepsy: From Bench to Bedside, Grand Rounds, University of Florida Department of Pediatrics, Dec 17, 2010 Neural Interface for Repair and Treatment of Epilepsy, Department of Neurology Grand Rounds, Wake Forest University, December 15, 2009 Neural Interface for Repair and Treatment: Potential for Epilepsy, Grand Rounds, Emory University/Georgia Tech, Atlanta, Department of Neuroscience, Sept. 9, 2008 4-D Neuroimaging 3rd Annual International Users Group Meeting, Barcelona, Spain, July 13-15 2008 Seventh Curso International de Neuropsiquiatria Infantile. Viña del Mar, Chile, May 30-31, 2008 XXIX Annual Child Neurology Postgraduate Course Miami Children’s Hospital. Topics: Sleep and Epilepsy and Epilepsy Co-Morbidity. Miami, Florida. May 2, 2008 Biomedical Engineering Update: University of Florida College of Engineering, Department of Biomedical Engineering Advisory Board Meeting, October 17, 2008 American Association of Critical-Care Nurses. Swamped with Knowledge 2008. Topic: To Seize or Not to Seize: That is the Question, Gainesville, FL, March 1, 2008 Conference on Computational Neuroscience 2008. Topic: Temporal Lobe Epilepsy: Anatomical and Effective Connectivity. University of Florida, Center for Applied Optimization, Gainesville FL February 20, 2008 Neural Interface for Repair and Treatment: Potential for Epilepsy, University of Florida Department of Neuroscience, January 16, 2008

Paul R. Carney, MD 47 Curriculum Vitae September, 2020

Neural Interface for Repair and Treatment: Potential for Epilepsy, Mt Sinai School of Medicine, New York, NY, September 17, 2007 Third International Seizure Prediction Workshop: Dynamics of a Limbic Epilepsy Model, Freiburg, Germany. September 30-October 4, 2007 State Key Laboratory of Brain and Cognitive Science Institute of Psychology, Chinese Academy of Sciences. Topic: Sleep disorders in children and adults. Beijing, China, November. 15, 2007 Capital Medical University Beijing Tiantan Hospital. Topic: Brain Machine Interface for Epilepsy. Beijing, China, November 15, 2007 International Conference on Translational Research, Peking Union Medical College Hospital (PUMC), Topic: Neural Interface for Repair and Treatment: Potential for Epilepsy. Beijing, China, November 11-13, 2007 Invited Participant, 4-D Neuroimaging 2rd Annual International Users Group Meeting, Denver, June 6-8, Data Mining, Systems Analysis & Optimization in Biomedicine University of Florida College of Engineering, March 28-30, 2007 60th Annual Meeting of the American Epilepsy Society, Sensing the Brain; Engineering Special Interest Group, Topic: Neural Prosthetic for Epilepsy, San Diego, CA. December 1, 2006 Florida Neurological Society, Topic: Epilepsy Behavioral and Cognitive Co-Morbidity in Pediatric Epilepsy: Recognition, Mechanisms, Assessment and Treatment. Orlando, Florida, December 14, 2006 23rd Congreso de Psiquiatria y Neurologia de la Infancia y la Adolescencia. Topics: Seizure Prediction; Emerging Technologies for Epilepsy: Diffusion Tensor Imaging and Photoacoustic Tomography. Viña del Mar, Chile, South America, Oct 12-14, 2006 Fourth International Sleep Disorders Forum Rome, Italy, 7-8 September, 2006 DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Gainesville, FL, Topic: Dynamical EEG Properties in the Limbic Epilepsy Rat Model, February 15-17, 2006 Neuroscience Grand Rounds, Topic: Pathophysiology of Temporal Lobe Epilepsy, University of Florida, February 5, 2006 Conference on Data Mining, Systems Analysis and Optimization in Neuroscience University of Florida. Topic: EEG Dynamics in an Animal Model of Temporal Lobe Epilepsy, February 15- 17, 2006 College of Engineering Recruitment, University of Florida, Gainesville, FL Topic: Brain Dynamics and Neural Networks in Epilepsy, February 17, 2006 Chilean Pediatric Society, Chile, 1st International Iberoamerican Pediatric Neurology Conference, Topics: Childhood Epilepsy and Childhood Sleep Disorders, October 6, 2005 American Academy of Neurology, Miami, FL, Topic: Seizure Prediction in a Limbic Model of Temporal Lobe Epilepsy, May 2, 2005

Paul R. Carney, MD 48 Curriculum Vitae September, 2020

Research Seminar Grand Rounds, Department of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL Topic: Brain Machine Interface for Epilepsy, September 14, 2005 Conference on Systems Analysis, Data Mining, and Optimization in Biomedicine, Topic: Dynamical Characteristics in Rat Chronic Limbic Epilepsy Model, University of Florida, Gainesville, FL. February 4, 2005 University of Valparaiso, Society for Pediatric Neurology, Topics: Pharmacoresistant Childhood Epilepsy and Evaluation and Treatment of Sleep Disorders, June, 2004 Grand Rounds, University of Arkansas, Department of Pediatrics. Topic: Modeling and Seizure Prediction, May 12, 2004 Grand Rounds, University of Florida, Department of Pediatrics, Jacksonville, FL, Title: Catastrophic Childhood Epilepsy: Advances in Diagnosis and Management, April, 23, 2004 Children’s Medical Services, Nursing Symposium, Topic: Childhood Sleep Disorders: Evaluation and Management, April 5, 2004 Conference on Data Mining in Biomedicine, Center for Applied Optimization, Modeling and Computation for Engineering, Science and Industry, College of Engineering, University of Florida, Gainesville, Topic: A Quantitative EEG Method for real-time Detection of Neonatal Seizures in the Neonatal Intensive Care Unit. February 16-18, 2004 Quantitative Neuroscience/Neural Engineering Seminar, University of Florida, Neonatal Seizures, March 2, 2004 The First International Collaborative Workshop on Seizure Prediction, International Seizure Prediction Group, Bonn, Germany. Topic: Seizure Prediction in a Generalized Epilepsy Animal Model, March, 10, 2003 University of Chile and University of Valparaiso, Chilean Pediatric Neurology Society, Valparaiso, Chile, 1st International Iberoamerican Pediatric Neurology Conference, Topics: Childhood Epilepsy and “Childhood Sleep Disorders, March 22, 2003 Florida Chapter AAP Annual Meeting and Florida Pediatric Alumni Association Annual Meeting, Topic: Recent Advances in the Diagnosis and Treatment of Pediatric Epilepsy. June 20, 2003 Recent Advances in Modeling and Prediction of Epileptic Seizures, Grand Rounds, Department of Neurology, Case Western Reserve University, Cleveland, OH, March 1, 2002 Practical Approach to the Diagnosis and Management of Sleep Disorders, North Florida Neurological Society, February 13, 2002 Biomedical Research Partnership seminar series. Colleges of Medicine and Biomedical Engineering. University of Florida. Talk: Seizure prediction in the H218 sphingosine 1- phosphate mouse model. January 15, 2002 American Epilepsy Society Annual Meeting, Special Interest Group and Participatory Roundtable, New Orleans, LA. Topic: Brain Dynamics in Rat Chronic Limbic Epilepsy Model, December 2, 2001 Predictability of seizures in a transgenic epilepsy-prone mouse model, Spring Epilepsy Research Conference, Cayman Islands, Platform session, April 25, 2001

Paul R. Carney, MD 49 Curriculum Vitae September, 2020

Sleep disordered breathing during childhood: diagnosis and treatment, Nemours Children Foundation Grand Rounds, Jacksonville, March 8, 2001 Children’s Miracle Network, Radio Telethon Fund Raiser. Interview reviews medical needs of children with complex neurologic problems, including epilepsy, sleep disorders, and developmental delay, August, 2001 Children’s Miracle Network, TV 20, Personal Portrait: Sara Higgins. Story reviews the personal experience of an 8-year-old child with refractory epilepsy undergoing a presurgical and surgical evaluation for epilepsy surgery, June, 2001 University of Florida/Shands Hospital Epilepsy Surgery Patient Reunion, Topic: New Anticonvulsant Drugs, September 11, 2000 Health in a Heartbeat radio program on WUFT-FM (Classic 89), Topic: Spinal muscular dystrophy, February 4, 2000 Public Relations, A Question of Health” TV 20, Theme: Sleep Disorders, Panel Member, January 17, 2000 Update on Epilepsy: Consensus Conference in Child Neurology, Orlando, FL, Management of medically refractory seizures, University of Florida, Department of Pediatrics, February 18,1999 University of Florida College of Medicine medical student and pediatric house officer rural medicine expedition and course (Nicaragua). Group leader: Donald Eitzman, M.D., February 9, 1999 Temporal lobe epilepsy surgery during childhood. Neurology Grand Rounds, State University of New York, Buffalo, NY, February 1, 1998 Evaluation and Treatment of the Seizing Child, University of Florida, Emergency Medicine Clinical Lecture, August, November 12, 1998 Cephalon, Inc., Speaker Bureau on Sleep Disorders Sleep Disorders. East Side Community Health Center: Florida representative Karen Chestnut, Acute repetitive seizures and other epileptic emergencies: management strategies, University of Florida, Department of Pediatrics, September 30, 1998 Pediatric epilepsy surgery; evaluation and management, University of Florida pediatric nursing in-service, August 29, 1998 Companies Founded Biom Therapeutics, LLC Neurotechion, LLC Chronobionics, LLC

Paul R. Carney, MD 50 Curriculum Vitae September, 2020