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Age Related Memory Loss Arml Program and Cognitive Aging And AGERELATED MEMORY LOSS ARML PROGRAM AND COGNITIVE AGING AND MEMORY CAM PROGRAM 2018 ANNUAL REPORT Prepared for the McKnight Brain Research Foundation by the University of Florida McKnight Brain Institute and Institute on Aging Table of Contents Letters from UF/MBI Leadership ................................................................................................................................................. 4-6 Age-related Memory Loss (ARML) Program and the Evelyn F. McKnight Chair for Brain Research in Memory Loss...... 7-26 Cognitive Aging and Memory Clinical Translational Research Program (CAM) and the Evelyn F. McKnight Chair for Clinical Translational Research in Cognitive Aging and CVs ........................................ 27-53 William G. Luttge Lectureship in Neuroscience ...............................................................................................................54-55 Faculty Biographical Sketches ........................................................................................................................................ 56-107 Evelyn F. McKnight Offi ce of UF Senior Vice President for Health Aff airs 1515 SW Archer Road, Suite 23C1 Gainesville, FL 32608 P.O. Box 100014 Gainesville, FL 32610-0014 Phone: 352.733.1700 Fax: 352.733.1201 UFHealth.org Patient Care ● Research ● Education UF Health is a collaboration of the University of Florida Health Science Center, Shands hospitals and other health care entities.s. 4 PO Box 100015 Gainesville, FL 32610-0015 352-273-8500 Office 352-846-0185 Fax mbi.ufl.edu January 18, 2019 The McKnight Brain Research Foundation SunTrust Bank Mail Code FL-ORL-Suite 1600 300 South Orange Avenue, Suite 1600 Orlando, FL 32801 Dear Trustees, We are pleased to submit the 2018 annual report of the activities of the ARML and CAM programs supported by the MBRF. The long-time enabling support of the MBRF and its members is deeply appreciated by both the members of the programs and the UF Health leadership. The aid of the MBRF has been vital to the discoveries made by our researchers, and with our work with other members of the aging research groups. Together, we have made exciting scientific advances toward understanding, treating, and preventing age-related memory loss. The multidisciplinary and unique foci of the ARML and CAM investigators, in comparative and human studies respectively, is a unique strength of our programs, and a source of recruiting of new faculty and new students to the field. This year we celebrated a special milestone in the history of the McKnight Brain Institute (MBI)—the 20th anniversary of the opening of the building and a major advance to the interdisciplinary neuroscience at UF. Two events were held to commemorate this: a scientific program held at the Harn Museum of Art and a celebration at the new Cade Museum. The scientific program featured outstanding keynote speakers Mary Woolley, president of Research!America, the nation’s largest non-profit public education and advocacy organization for medical and health research, and Jennifer French, executive director of the Neurotech Network and one of the world’s first “bionic women.” The evening also contrasted the accomplishments of the MBI’s first 20 years with the exciting prospects for future research across the wide array of neuroscience research programs now affiliated with the MBI. We finished the year enjoying a superb evening with food, music, and remembrance of Bill Luttge and his efforts, and the MBRF’s wonderful contribution to making the MBI a reality. The ARML and CAM programs have continued to enjoy great success, as indicated in the enclosed report. Grant funding, qualifications of applicants to train in the programs, and their productivity are outstanding. Together with our collaborations with the other three McKnight Brain Institutes, the programs are also increasing their professional and public status; social media efforts have shown growth as well. The CAM and ARML programs are truly jewels of the MBI. Wise selection by the leadership of faculty, post- doctoral fellows and graduate students have led to new NIH grants in both programs, at least half a dozen new PhDs awarded, and notably, a number of training grants, T32s, to attract and train the next generation of scientists to the field, Increased size of both programs has occurred in the past year, and in addition the programs have leveraged new pilots and other exploratory grants in collaboration with the department of aging and geriatric research. New activities conceived by the MBI executive committee are designed to: • further enhance neuroscience education, • provide greater diversity in our trainees, and • increase the visibility of, and recruiting capacity for, new faculty and trainees at UF and nationally. Our outstanding science writer, Michelle Jaffee, and our Communications Director, Todd Taylor, not only help support these activities and publicize our work, but have the accomplishments of our researchers more visible on The Foundation for the Gator Nation An Equal Opportunity Institution 5 our continually updated and informative website (www.MBI.ufl.edu) and the MBI newsletter, The Brainstorm. Moreover, they have raised our visibility with invigorated Twitter, Facebook, and other social media sites. Data from all of these sources indicate that these efforts have succeeded in communicating the work supported by the MBRF to an increasingly widespread audience. The MBI visiting scholars program and the ongoing recruitments in aging researchers have added to our broad educational programs, all of which complement the Luttge Lectureship and enable additional prominent brain aging investigators to visit the UF campus. For example, the MBI Research Evenings, feature short, thematically organized presentations and provide networking opportunities. Trainee Enhancement Opportunities, similar to UF Faculty Enhancement Opportunities, allow research fellows, clinical fellows and graduate students to increase their skills and develop new methodologies attending courses, learning new techniques, or exploring areas of neuroscience beyond their home labs, enabling recipients to become truly interdisciplinary in their views and skills. We continue to support the Summer Neuroscience Internship Program (SNIP; directed by Dr. Sara Burke of ARML and Dr. Jada Lewis of the CTRND), with over 25 undergraduates,60% of whom are under-represented minority students. Our Research Fellowship program continues to provide pilot funds to trainees and junior scientists, enhanced by collaboration and cost sharing with our colleagues in the department of aging and geriatric research. Importantly, as a part of our mission we fund MBI travel awards to neuroscientists at UF who do not have the funds to attend conferences both here and abroad. If we could, we would name all of our fantastic faculty who have made extraordinary contributions to the MBRF programs, however, in this overview we will limit the narrative to a listing of those who have received new NIH grants and awards worthy of note. The ARML had three new R01s awarded this year, to Dr. Foster, Drs. Burke and Bizon, and another a multi-PI grant to Dr. Bizon. Dr. Burke received the McKnight Brain Institute Leadership award for 2018, and she was also honored with an Exemplary Teaching Award from the UF College of Medicine for her leadership of the SNIP. Dr. Bizon was awarded a UF Term Professorship in recognition of her work, and both Dr. Bizon and Dr. Foster were recognized with UF Research Foundation Awards, given both for their research accomplishments and for the likelihood of their continued excellent work. The CAM program has had an equally outstanding year. Working from their new positions in the College of Public Health and Health Professions and their new labs in the MBI, they have increased their staff to 18 coordinators and 7 graduate students. In addition, 4 students received their PhDs. Dr. Cohen received two new R01s, and Dr. Woods received a U01 grant. Dr. Woods has been so productive that he is being proposed for early promotion and tenure. Dr. Williamson was awarded an R1, and Dr. Aprinda Indahlastari received the NYC Neuromodulation and North American Neuromodulation Society Young Investigator award, under Dr. Woods. The ARML and CAM have developed a 5-year strategic plan, which includes collaborations with the other three MBRF sites. Since the MBI’s strategic plan is programmatically based, it will be easy to integrate the MBRF plan, enhancing interactions among the MBRF-supported and other MBI programs to further elevate our science. Finally, we continue to do upgrades to the laboratories and facilities to provide optimal space for our researchers to work, and to enable more recruiting to our basic, translational, and clinical research programs. The CAM and ARML programs are exceeding our expectations, and we continue to be grateful to the MBRF Board for both your passion and support. Sincerely, Todd E. Golde, M.D., Ph.D. Steven T. DeKosky, MD Director Deputy Director Director, 1Florida Alzheimer’s Disease Research Center Aerts-Cosper Professor of Alzheimer’s Research Professor, Department of Neuroscience Associate Director, 1Florida ADRC College of Medicine Professor6 of Neurology and Neuroscience Age-related Memory Loss (ARML) Program and the Evelyn F. McKnight Chair for Brain Research in Memory Loss 2018 PROGRESS REPORT PO Box 100015 Gainesville, FL 32610-0015 352-273-8500 Office 352-846-0185 Fax mbi.ufl.edu Age-Related Memory Loss Program (ARML) The
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