Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
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Nutrition — Ph.D. 1
Nutrition — Ph.D. 1 NUTRITION — PH.D. Prerequisites • Master's degree in nutrition preferred; or an M.S. or M.P.H. degree Program director with completion of all prerequisite courses; or a health professional Sujatha Rajaram degree at the master's level or higher (M.D. or equivalent) • Advanced biochemistry (may be taken concurrently with the program) The Doctor of Philosophy (Ph.D.) degree in nutrition prepares students to • Anatomy and physiology, microbiology, general chemistry, and effectively conduct nutrition research as well as apply nutritional science organic chemistry knowledge and appropriate research methods to address public health problems. The program provide's an advanced curriculum in nutrition, • G.P.A. of 3.5 or higher preferred th professional skills, and competencies required to support careers in • GRE or equivalent (above the 40 percentile in each section is teaching and research. This program is uniquely situated in the School favorable) of Public Health at a health sciences university. The program engages in interdisciplinary research, encouraging collaboration across public Individuals who may benefit from the health disciplines and the basic sciences, promoting and building upon its core legacy of vegetarian and plant-based nutrition. Areas of curricular program strength and research emphasis include plant-based diets and the health Individuals seeking careers in: of the individual, populations and the planet, nutritional epidemiology, diet • Academia (teaching and research) and chronic disease-risk reduction, and community nutrition. • Researcher in private industry, governmental agencies, nonprofit Students enrolled in this program are able to concurrently complete organizations, or research institutes coursework and practice experience necessary to sit for the registered • Public health nutritionist dietitian nutritionist (RDN) exam if not already an RDN. -
The Practice of Epidemiology
The Practice of Epidemiology A Meta-Regression Method for Studying Etiologic Heterogeneity across Disease Subtypes Classified by Multiple Biomarkers Molin Wang, Aya Kuchiba, Shuji Ogino Correspondence to Molin Wang, Departments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, 677 Huntington Ave., Boston, Massachusetts (email: [email protected]) Abbreviations: CIMP, CpG island methylator phenotype; HPFS, Health Professionals Follow-up Study; MPE, molecular pathological epidemiology; MSI, microsatellite instability; MSS, microsatellite stable; NHS, the Nurses’ Health Study; OR, odds ratio; RR, relative risk; RRR, ratio of relative risk. We use standardized official symbol BRAF, which is described at www.genenames.org. Word count main abstract: 200 Word count text: 3615 N.Figures: 0 N.Tables: 2 Appendices: 0 1 Abstract In interdisciplinary biomedical, epidemiological, and population research, it is increasingly necessary to consider pathogenesis and inherent heterogeneity of any given health condition and outcome. As the unique disease principle implies, no single biomarker can perfectly define disease subtypes. The complex nature of molecular pathology and biology necessitates biostatistical methodologies to simultaneously analyze multiple biomarkers and subtypes. To analyze and test for heterogeneity hypothesis across subtypes defined by multiple categorical and/or ordinal markers, the authors developed a meta-regression method that can utilize existing statistical software for mixed model analysis. This method can be used to assess whether the exposure- subtype associations are different across subtypes defined by one marker while controlling for other markers, and to evaluate whether the difference in exposure- subtype association across subtypes defined by one marker depends on any other markers. -
Chemical, Biological, and Environmental Factors Responsible for The
CHEMICAL, BIOLOGICAL, AND ENVIRONMENTAL FACTORS RESPONSIBLE FOR THE - -v - - - IN THE AUBURN CITY WATER SUPPLY AGRICULTURAL EXPERIMENT STATION/AUBURN UNIVERSITY R. DENNIS ROUSE, DIRECTOR AUBURN, ALABAMA BULLETIN 490 JULY 1977 CONTENTS Page INTRODUCTION ........ .. .. ............... 3 Background on Odors of Biological Origin in Water .......................... 3 Odor in the Auburn Water ........................... 5 PROCEDURES ............................ 5 RESULTS AND DISCUSSION ........... ...... .......... 7 Biological Factors................................ 7 Chemical Factors ............................... 22 Environmental Factors Related to the Growth and Production of Odorous Substances by Actinomycetes ....... 24 Correlation of Rainfall, Temperature, and Threshold Odor Number (TON) ................... 39 SUMMARY ... ... ...................... ........... 41 REFERENCES ................... ....... ... .......... 45 FIRST PRINTING 3M, JULY 1977 ACKNOWLEDGEMENTS The authors wish to thank the Auburn Water Board for the financial support of this project, the Auburn Water Treatment Plant for supplying TON values, Dr. John Lawrence for use of the carbon analyzer, and Sandy Williams, Frank Seesock, and Susan Brownlee for technical assistance. Information contained herein is available to all without regard to race, color, or nationalorigin. CHEMICAL, BIOLOGICAL, and ENVIRONMENTAL FACTORS RESPONSIBLE for the EARTHY ODOR in the AUBURN CITY WATER SUPPLY J. D. WEETE, W. T. BLEVINS, G. R.WILT, and D. DURHAM' INTRODUCTION Background On Odors Of Biological Origin in Water HE OCCURRENCE of objectionable odors in water used for drinking and commercial purposes is well documented in certain regions of the United States (1, 4, 12, 15) and various other parts of the world. (1, 8, 9, 11). Odors in sur- face waters may originate from industrial and municipal sewage effluents or from biological activities of algae or heterotrophic microorganisms. Odors of biological origin may be due to decomposition of organisms or to the produc- tion of microbial metabolites. -
Encouraging Healthy Lifestyle Practices to Protect Health from Environmental Pollution
Encouraging Healthy Lifestyle Practices to Protect Health from Environmental Pollution Dawn Brewer, PhD, RD, LD July 26, 2019 NIEHS Superfund Research Program (SRP) Purpose: The NIEHS SRP supports research that provides practical, scientific solutions to protect health, the environment and communities. Source: https://tools.niehs.nih.gov/srp/sites/www.cfm University of Kentucky Superfund Research Center (UK-SRC): Nutrition and Superfund Chemical Toxicity Polychlorinated biphenyls (PCBs) Cl Cl Cl Cl Cl Exposure Cardiovascular diseases Diabetes Obesity Cancer Oxidative Suppression of the immune system damage Dysfunction of reproductive and nervous systems Source: Sci Total Environ. 2009 Dec 1; 407(24): 6109-6119 Source: http://www.epa.gov/opptintr/pcb/ Kentucky Contains Hundreds of Hazardous Waste Sites and Contaminated Waterways • 13 National Priority List sites • 248 state superfund sites • 465 sites pending review • Fish consumption advisories for PCBs exist for Kentucky streams and the entire Ohio River that forms the northern border Source: https://www.kyforward.com/wp-content/uploads/2018/11/Kentucky- Waterways-map.jpg Kentucky Experiences Poor Health Outcomes United Health Indicator Kentucky States Ranking Diabetes (%) 12.9 10.5 44 Heart disease (%) 6.2 3.9 49 Cancer deaths (per 100,000 population) 234.9 189.8 50 High blood pressure (%) 39.4 32.2 46 Obesity (%) 34.3 31.3 43 Source: America's Health Rankings analysis of CDC WONDER Online Database, Underlying Cause of Death, Multiple Cause of Death files, United Health Foundation, AmericasHealthRankings.org, Accessed 2019. Kentuckians Face Increased Vulnerability to Environmental Pollution • A growing and convincing body of research (including results from UK-SRC) indicates that nutrition may function as a modulator of vulnerability to environmental insults with nutrition serving to both better or worsen the health impacts associated with exposure to environmental toxins. -
Master of Public Health/Master of Science in Nutrition Dual Degree Proposal (Plan B, Non-Thesis Requiring) Document of December
Master of Public Health/Master of Science in Nutrition Dual Degree Proposal (Plan B, non-thesis requiring) Document of December 8, 2014; Revised February 2, 2015 This is a dual degree program that is offered jointly by the Departments of Epidemiology and Biostatistics, and Nutrition. The core Master Degree courses include a mixture of those from nutrition, biochemistry and public health. 1. Background and Justification The World Health Organization, (WHO), identifies diet and nutrition as a lifestyle factor critical for maintenance of health and well-being, as well as a factor influencing risk of chronic disease. Cardiovascular disease, diabetes, cancer and obesity are examples of chronic diseases significantly related to diet and nutrition. Obesity is one of the most common conditions and is growing to epidemic proportions. The two most common associated co-morbidities of obesity, type 2 diabetes and hypertension, are highly prevalent health risks and are among the principal causes of death in the general population. Additionally, in third world countries, malnutrition is a very common cause of infection or death, especially in young children. Accordingly, knowledge of the basic elements of good nutrition and the biochemical pathways associated with the metabolism of protein, fat and carbohydrate offers important contributions to mitigate these health problems. The proposed dual degree program will provide the student with a core understanding of the mechanics of metabolism combined with advanced courses in public health and nutrition. This combined approach will yield a highly qualified and competitive public health practitioner trained to develop evidence based policy, programs, strategies and advocacy to address these health risks and problems. -
Hyperplasia (Growth Factors
Adaptations Robbins Basic Pathology Robbins Basic Pathology Robbins Basic Pathology Coagulation Robbins Basic Pathology Robbins Basic Pathology Homeostasis • Maintenance of a steady state Adaptations • Reversible functional and structural responses to physiologic stress and some pathogenic stimuli • New altered “steady state” is achieved Adaptive responses • Hypertrophy • Altered demand (muscle . hyper = above, more activity) . trophe = nourishment, food • Altered stimulation • Hyperplasia (growth factors, . plastein = (v.) to form, to shape; hormones) (n.) growth, development • Altered nutrition • Dysplasia (including gas exchange) . dys = bad or disordered • Metaplasia . meta = change or beyond • Hypoplasia . hypo = below, less • Atrophy, Aplasia, Agenesis . a = without . nourishment, form, begining Robbins Basic Pathology Cell death, the end result of progressive cell injury, is one of the most crucial events in the evolution of disease in any tissue or organ. It results from diverse causes, including ischemia (reduced blood flow), infection, and toxins. Cell death is also a normal and essential process in embryogenesis, the development of organs, and the maintenance of homeostasis. Two principal pathways of cell death, necrosis and apoptosis. Nutrient deprivation triggers an adaptive cellular response called autophagy that may also culminate in cell death. Adaptations • Hypertrophy • Hyperplasia • Atrophy • Metaplasia HYPERTROPHY Hypertrophy refers to an increase in the size of cells, resulting in an increase in the size of the organ No new cells, just larger cells. The increased size of the cells is due to the synthesis of more structural components of the cells usually proteins. Cells capable of division may respond to stress by undergoing both hyperrtophy and hyperplasia Non-dividing cell increased tissue mass is due to hypertrophy. -
Commentary: Facing the Challenge of Gene-Environment Interaction: the Two-By-Four Table and Beyond
American Journal of Epidemiology Vol. 153, No. 10 Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health Printed in U.S.A. All rights reserved The Challenge of Gene-Environment Interaction Botto and Khoury PRACTICE OF EPIDEMIOLOGY Commentary: Facing the Challenge of Gene-Environment Interaction: The Two-by-Four Table and Beyond Lorenzo D. Botto1 and Muin J. Khoury2 As a result of the Human Genome Project, epidemiologists can study thousands of genes and their interaction with the environment. The challenge is how to best present and analyze such studies of multiple genetic and environmental factors. The authors suggest emphasizing the fundamental core of gene-environment interaction—the separate assessment of the effects of individual and joint risk factors. In the simple analysis of one genotype and an exposure (both dichotomous), such study can be summarized in a two-by-four table. The advantages of such a table for data presentation and analysis are many: The table displays the data efficiently and highlights sample size issues; it allows for evaluation of the independent and joint roles of genotype and exposure on disease risk; and it emphasizes effect estimation over model testing. Researchers can easily estimate relative risks and attributable fractions and test different models of interaction. The two-by-four table is a useful tool for presenting, analyzing, and synthesizing data on gene-environment interaction. To highlight the role of gene-environment interaction in disease causation, the authors propose that the two-by-four table is the fundamental unit of epidemiologic analysis. Am J Epidemiol 2001;153:1016–20. -
Environmental Factors Affecting the Composition and Diversity of The
Imai et al. Journal of Ecology and Environment (2017) 41:8 Journal of Ecology DOI 10.1186/s41610-017-0027-2 and Environment RESEARCH Open Access Environmental factors affecting the composition and diversity of the avian community in igune, a traditional agricultural landscape in northern Japan Haruka Imai1*, Tohru Nakashizuka1,2 and Michio Oguro1,3 Abstract Background: “Igune,” a traditional agricultural landscape in the Tohoku region of Japan, is characterized by small-scale artificial woodlots surrounding a farmer’s house that are interspersed with paddy fields. During the rapid economic growth of Japan over recent decades, some igune woodlots have been abandoned or logged. Biodiversity conservation is an important issue worldwide, and traditional agricultural landscapes are of particular interest. To elucidate the role of igune landscapes in conserving biodiversity, we examined the effects of environmental factors on avian communities. Results: The study was conducted in the suburban areas of Oshu and Hanamaki cities, Iwate Prefecture, Japan, at eight sites that varied in the density and area of igune woodlots within the landscape. Bird surveys were conducted from the middle to late breeding season, and several environmental factors of the igune landscape were also measured. The results of canonical correspondence analysis indicated that the characteristics of avian communities were mainly determined by the total forested area in the landscape. Increased total forested area and shrubs layer of igune woodlots did not cause a reduction in number of bird species of any habitat and foraging types, while increased both in species number and abundance of insectivores and forest species. The number of raptor species increased in igune sites without shrubs. -
Vitamin and Mineral Requirements in Human Nutrition
P000i-00xx 3/12/05 8:54 PM Page i Vitamin and mineral requirements in human nutrition Second edition VITPR 3/12/05 16:50 Page ii WHO Library Cataloguing-in-Publication Data Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements (1998 : Bangkok, Thailand). Vitamin and mineral requirements in human nutrition : report of a joint FAO/WHO expert consultation, Bangkok, Thailand, 21–30 September 1998. 1.Vitamins — standards 2.Micronutrients — standards 3.Trace elements — standards 4.Deficiency diseases — diet therapy 5.Nutritional requirements I.Title. ISBN 92 4 154612 3 (LC/NLM Classification: QU 145) © World Health Organization and Food and Agriculture Organization of the United Nations 2004 All rights reserved. Publications of the World Health Organization can be obtained from Market- ing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 2476; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permis- sion to reproduce or translate WHO publications — whether for sale or for noncommercial distri- bution — should be addressed to Publications, at the above address (fax: +41 22 791 4806; e-mail: [email protected]), or to Chief, Publishing and Multimedia Service, Information Division, Food and Agriculture Organization of the United Nations, 00100 Rome, Italy. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization and the Food and Agriculture Organization of the United Nations concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. -
How Much Global Ill Health Is Attributable to Environmental Factors?
ORIGINAL ARTICLES How Much Global Ill Health Is Attributable to Environmental Factors? Kirk R. Smith,1 Carlos F. Corvalán2, and Tord Kjellström3 Over the years, estimates have been made of the portions of attributed to environmental risk factors. Children under 5 human mortality and morbidity that can be attributed to years of age seem to bear the largest environmental burden, environmental factors. Frustratingly, however, even for a and the portion of disease due to environmental risks seems single category of disease such as cancer, these estimates to decrease with economic development. A summary of have often varied widely. Here we attempt to explain why these estimates first appeared in the 1997 report, "Health such efforts have come to such different results in the past and Environment in Sustainable Development," which was and to provide guidance for doing such estimates more the World Health Organization's contribution to the 5-year consistently in the future to avoid the most important pitfalls. anniversary of the Rio Earth Summit. A full explanation of We do so by carefully defining what we mean by the terms how these estimates were made is first presented here. We "environmental," "ill health," and "attributable." Finally, end with a call for a program of "strategic epidemiology," based on these recommendations, we attempt our own which would be designed to fill important gaps in the estimate, appropriately qualified according to the many understanding of major environmental health risks in remaining uncertainties. Our estimate is that 25-33% of the important population groups worldwide. (Epidemiology global burden of disease can be 1999;10:573-584) Keywords: environmental exposures, morbidity, mortality, children, environmental health risks, populations, global factors, public health. -
Neurological Manifestation of Sacral Tumors
Neurosurg Focus 15 (2):Article 1, 2003, Click here to return to Table of Contents Neurological manifestation of sacral tumors MICHAEL PAYER, M.D. Department of Neurosurgery, University Hopital of Geneva, Switzerland An extensive analysis of the existing literature concerning sacral tumors was conducted to characterize their clin- ical manifestations. Although certain specific manifestations can be attributed to some of the tumor types, a more general pattern of clinical presentation of an expansive sacral lesion can be elaborated. Local pain with or without pseudoradicular or radicular radiation is the most frequent initial symptom and is usually followed by the manifesta- tion of a lumbosacral sensorimotor deficit; bladder/bowel and/or sexual dysfunction appear throughout the natural course of disease. KEY WORDS • sacrum • tumor • lesion • neurological presentation All sacral and presacral tumors are rare.32,93 In one se- REVIEW OF SACRAL ANATOMY ries patients with these tumors were estimated to account for approximately one in 40,000 hospital admissions.93 Osseous Structures of the Sacrum Tumors arising from the bone of the sacrum are by far the The sacrum is a complex bone, comprising five sacral most frequent sacral tumors; chordomas are the most com- vertebrae that have fused. In its center lies the longitudi- mon and GCTs the second most common.20,46,50,61,74,81,98 nal sacral canal, which opens caudally posteriorly into the Although sacrococcygeal teratoma is the most common sacral hiatus, an incomplete posterior closure of the S-5 sacral tumor in neonates, it is very rare in adults.30,45,66 lamina. The thick anterior or pelvic face of the sacrum is The author conducted an extensive analysis of the exist- concave and contains four right- and left-sided anterior ing literature concerning tumors of the sacrum to charac- sacral foramina. -
The Diagnostic and Prognostic Value of a Liquid Biopsy for Esophageal Cancer: a Systematic Review and Meta-Analysis
cancers Review The Diagnostic and Prognostic Value of a Liquid Biopsy for Esophageal Cancer: A Systematic Review and Meta-Analysis Daisuke Matsushita 1,* , Takaaki Arigami 2 , Keishi Okubo 1, Ken Sasaki 1, Masahiro Noda 1, Yoshiaki Kita 1, Shinichiro Mori 1, Yoshikazu Uenosono 3, Takao Ohtsuka 1 and Shoji Natsugoe 4 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan; [email protected] (K.O.); [email protected] (K.S.); [email protected] (M.N.); [email protected] (Y.K.); [email protected] (S.M.); [email protected] (T.O.) 2 Department of Onco-biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan; [email protected] 3 Department of Surgery, Jiaikai Imamura General Hospital, Kagoshima 890-0064, Japan; [email protected] 4 Department of Surgery, Gyokushoukai Kajiki Onsen Hospital, Aira 899-5241, Japan; [email protected] * Correspondence: [email protected]; Tel.: +81-99-275-5361; Fax: +81-99-265-7426 Received: 9 September 2020; Accepted: 18 October 2020; Published: 21 October 2020 Simple Summary: The “liquid biopsy” is a novel concept for detecting circulating biomarkers in the peripheral blood of patients with various cancers, including esophageal cancer. There are two main methods to identify circulating cancer related biomarkers such as morphological techniques or molecular biological techniques.