1 Classification: BIOLOGICAL SCIENCES: Microbiology; Plant Biology 2 3 Title: Antitumor astins originate from the fungal endophyte Cyanodermella asteris living 4 within the medicinal plant Aster tataricus 5 Short title: Astins originate from the fungus C. asteris 6 7 Authors: 8 T Schafhausera,b,d,1, L Jahnb,1, N Kirchnerc, A Kulika, L Flord, A Langd, T Caradece, DP Fewerf, K 9 Sivonenf, WJH van Berkelg, P Jacquese,h, T Weberi, H Grossc, KH van Péed, W Wohllebena,2,3 and 10 J Ludwig-Müllerb,2,3 11 1equal contribution 12 2these authors share senior authorship 13 3corresponding authors:
[email protected], phone: +49-70712976944; 14
[email protected], phone: +49-35146333939 15 16 aMicrobiology and Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, Eberhard Karls 17 University Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany 18 bInstitute of Botany, TU Dresden, Zellescher Weg 20b, 01217 Dresden, Germany 19 cPharmaceutical Institute, Department of Pharmaceutical Biology, Eberhard Karls University Tübingen, Auf der 20 Morgenstelle 8, 72076 Tübingen, Germany 21 dGeneral Biochemistry, TU Dresden, 01062 Dresden, Germany 22 eUniversity Lille, INRA, ISA, University Artois, University Littoral Côte d’Opale, EA 7394 – ICV – Institut Charles 23 Viollette, Lille, France 24 fDepartment of Microbiology, University of Helsinki, Viikinkaari 9, FI-00014, Helsinki, Finland 25 gLaboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The 26 Netherlands 27 hTERRA Teaching and Research Centre, Microbial Processes and Interactions, Gembloux Agro-Bio Tech University 28 of Liege, Gembloux, Belgium 29 iThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet bygning 30 220, 2800 Kgs.