DOCSLIB.ORG

Review Article Cinnamon: a Multifaceted Medicinal Plant

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Review Article Cinnamon: a Multifaceted Medicinal Plant Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 642942, 12 pages http://dx.doi.org/10.1155/2014/642942 Review Article Cinnamon: A Multifaceted Medicinal Plant Pasupuleti Visweswara Rao1,2 and Siew Hua Gan2 1 FacultyofAgroBasedIndustry,UniversitiMalaysiaKelantan,JeliCampus,LockedBagNo.100,17600Jeli,Kelantan,Malaysia 2 Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia Correspondence should be addressed to Pasupuleti Visweswara Rao; [email protected] Received 1 January 2014; Accepted 12 March 2014; Published 10 April 2014 Academic Editor: Mohammad Amjad Kamal Copyright © 2014 P. V. Rao and S. H. Gan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cinnamon (Cinnamomum zeylanicum, and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family. Cinnamon is one of the most important spices used daily by people all over the world. Cinnamon primarily contains vital oils and other derivatives, such as cinnamaldehyde, cinnamic acid, and cinnamate. In addition to being an antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against neurological disorders, such as Parkinson’s and Alzheimer’s diseases. This review illustrates the pharmacological prospective of cinnamon and its use in daily life. 1. Introduction extracted from cinnamon and berries also possess antioxi- dant activities [10, 12]. The bark of various cinnamon species is one of the most important and popular spices used worldwide not only for cooking but also in traditional and modern medicines. Over- 2. Methodology all, approximately 250 species have been identified among the cinnamon genus, with trees being scattered all over the world The current review was conducted using a complete and [1, 2]. organizedsearchoftheavailableliteratureonthemedicinal Cinnamon is mainly used in the aroma and essence plantcinnamonfrom1982to2013.Thesearcheswere industries due to its fragrance, which can be incorporated performed using various databases, including PubMed into different varieties of foodstuffs, perfumes, and medicinal (http://www.ncbi.nlm.nih.gov/pubmed), Science Direct products [3]. The most important constituents of cinnamon (http://www.sciencedirect.com/), Scopus (http://www.scopus are cinnamaldehyde and trans-cinnamaldehyde (Cin), which .com/), Scirus (http://www.scirus.com/), and Google Scholar are present in the essential oil, thus contributing to the (http://www.scholar.google.com/). fragrance and to the various biological activities observed with cinnamon [4]. A study on Cinnamomum osmophloeum 3. Traditional Uses (C. osmophloeum) indicated that the essential oil from cin- namon leaves contains a high level of Cin. Consequently, In addition to being used as a spice and flavoring agent, C. osmophloeum is also used as an alternative spice for C. cinnamon is also added to flavor chewing gums due to its cassia [5]. One of the major constituents of essential oil mouthrefreshingeffectsandabilitytoremovebadbreath[13]. extracted from C. zeylanicum named (E)-cinnamaldehyde Cinnamon can also improve the health of the colon, thereby has an antityrosinase activity [6], while cinnamaldehyde is reducing the risk of colon cancer [14]. the principal compound responsible for this activity [7]. Cinnamon is a coagulant and prevents bleeding [15]. Cinnamon bark contains procyanidins and catechins [8]. Cinnamon also increases the blood circulation in the uterus The components of procyanidins include both procyani- and advances tissue regeneration [16]. This plant plays a vital din A-type and B-type linkages [9–11]. These procyanidins role as a spice, but its essential oils and other constituents also 2 Evidence-Based Complementary and Alternative Medicine O O O H OH O (a) Cinnamaldehyde (b) Cinnamic acid (c) Cinnamyl acetate Figure 1: Cinnamyl group-containing compounds. H HO (a) -Thujene (b) - (c) -Cubebene Terpineol Figure 2: Endocyclic double bond-containing compounds. have important activities, including antimicrobial [17–20], Table 1: Chemical constituents of different parts of cinnamon136 [ ] antifungal [21], antioxidant [22–26], and antidiabetic [27–33]. (Vangalapati et al., 2012 [2]). Cinnamonhasbeenusedasanti-inflammatory[34–36], antitermitic [36], nematicidal [37, 38], mosquito larvicidal Part of the plant Compound Cinnamaldehyde: 1.00 to 5.00% [39], insecticidal [40], antimycotic, [40–43] and anticancer Leaves agent [44–47]. Cinnamon has also been traditionally used as Eugenol: 70.00 to 95.00% tooth powder and to treat toothaches, dental problems, oral Cinnamaldehyde: 65.00 to 80.00% Bark microbiota, and bad breath [48, 49]. Eugenol: 5.00 to 10.00% Root bark Camphor: 60.00% 4. Chemical Constituents trans-Cinnamyl acetate (42.00 to 54.00%) Fruit and caryophyllene (9.00 to 14.00%) Cinnamon consists of a variety of resinous compounds, Terpene hydrocarbons: 78.00% including cinnamaldehyde, cinnamate, cinnamic acid, and numerous essential oils [50](Table 1). Singh et al. [51] C. zeylanicum buds alpha-Bergamotene: 27.38% reported that the spicy taste and fragrance are due to the alpha-Copaene: 23.05% presence of cinnamaldehyde and occur due to the absorption Oxygenated terpenoids: 9.00% of oxygen. As cinnamon ages, it darkens in color, improving (E)-Cinnamyl acetate: 41.98% the resinous compounds [51]. Sangal reported various phys- C. zeylanicum flowers trans-alpha-Bergamotene: 7.97% iochemical properties of cinnamon (Table 2). The presence of Caryophyllene oxide: 7.20% awiderangeofessentialoils,suchastrans-cinnamaldehyde, cinnamyl acetate, eugenol, L-borneol, caryophyllene oxide, b-caryophyllene, L-bornyl acetate, E-nerolidol, -cubebene, -terpineol, terpinolene, and -thujene, has been reported [35, 36]. antioxidants have been used to delay or prevent food spoilage. The chemical structures of some important constituents Spices and medicinal plants have received rapid consideration of cinnamon are shown in Figures 1, 2, 3, 4,and5. as sources of beneficial antioxidants against various diseases [52]. Antioxidants have been considered the most important 5. Antioxidant Activity drivers in the progress and existence of humans, as they respond to free radicals and damage in metabolic diseases and Antioxidant compounds present in foodstuffs play a vital age-related syndromes of humans and other animals [53, 54]. role in human life, acting as health-protecting agents. In Mancini-Filho et al. reported various extracts of cin- addition to this role, antioxidants are one of the key additives namon, such as ether, aqueous, and methanolic extracts used in fats and oils. Even in the food processing industry, that have shown considerable antioxidant activities [22]. Evidence-Based Complementary and Alternative Medicine 3 OH OCH3 (a) Eugenol (b) -Caryophyllene (c) Ter- pinolene Figure 3: Unconjugated exocyclic double bond-containing compounds. HO H O H OH (a) E-Nerolidol (b) L-Borneol (c) Borneol Figure 4: Hydroxy-substituted aliphatic compounds. A study on rats reported that the administration of the bark essential oils were more effective than the other two com- powderof C. verum (10%) for 90 days produced antioxidant pounds [61]. In a comparative study among 26 spices, cinna- activities as indicated by cardiac and hepatic antioxidant mon showed the highest antioxidant activity, indicating that enzymes, lipid conjugate dienes, and glutathione (GSH) [55]. it can be applied as an antioxidant used in foods [62]. Another A research group reported that cinnamon oil potentially study investigated the effectiveness of a mixture of spices on exhibits superoxide-dismutase- (SOD-) like activity as indi- oxidative stress markers as well as the antioxidant activity in cated by the inhibition of the inhibiting capacity of pyrogallol high fructose-fed insulin-resistant rats. The mixture, which autoxidation [56]. consisted of 1 g/100 g cinnamon bark, showed a significant The aqueous and alcoholic extract (1 : 1) of cinnamon antioxidant activity compared to the fructose alone group potentially significantly inhibits fatty acid oxidation and [63]. Volatile oils from C. zeylanicum showed significant lipid peroxidation in vitro [23]. Different flavonoids isolated biological activities [64]. from cinnamon have free-radical-scavenging activities and Forty-one different volatile compounds in the bark oil antioxidant properties [57]. A study of the inhibitory effects of of cinnamon have been identified and were found to vary cinnamaldehyde and other compounds of cinnamon on nitric significantly in percentage composition depending on the oxide production revealed that cinnamaldehyde possesses growth stages and segments of the C. cassia tree [65]. potentialactivityagainsttheproductionofnitricoxideas To extract essential oil for industrial use, the yields and well as the expression of inducible nitric oxide. The highest compositions of bark oil during Cinnamomum cassia growth inhibitory activities were reported as 81.5%, 71.7%, and 41.2% (1–3 years old for the branch bark and 5–12 years old for the at 1.0, 0.5, and 0.1 g/L, respectively [58]. Lin et al. reported stem bark) were determined. These researchers also found the in vivo antioxidant activity of two different
Load more

Recommended publications
  • Research Bulletin
    Research Bulletin Contents Secondary metabolites of Goniothalamus 2 spp. in Sarawak Micropropagation of Aquilaria malaccensis 3 Lank. and Aquilaria microcarpa Baill. sp. Coelogyne Diversity and phylogenetics study of 5 Hipposideros A convenient way for the etherification of 8 p-hydroxyacetophenone Census survey of saltwater crocodile 9 Crocodylus porosus in Batang Samarahan, Sarawak Coelogyne sp.2 In vitro cytotoxicity and antitermite activities 11 of the essential oil of Cinnamomum zeylanicum The role of palaeofloras and Bornean aroids 12 Coelogyne radioferens in the investigation of phytochores Coelogyne cf. moultonii Junior Science Camp UNIMAS 2011: 14 `Learning SCIENCE IS FUN’ Coelogyne cf. hirtella Some Coelogyne spp. of Sarawak (photograph courtesy of Qammil Muzzammil Abdullah) Development and characterization of 15 expressed sequence tag-simple sequence repeat markers from Kelampayan tree Dean’s Message transcriptome (NcdbEST) Prof. Dr. Shabdin Mohd Long Universiti Malaysia Sarawak has been ranked among the top 200 Asian University by the QS Asian University Rankings 2011 and Faculty of Resource Science and Technology (FRST) was ranked top 115 by QS Asian University Rankings 2011. Faculty members should be proud on our standing and this was achieved due to high commitment and enthusiasm of all staffs. I am sure with strong commitment and hard work we can achieve even better ranking. In line with the university‟s vision to become a research university by 2015, the faculty greatly supports any initiative to bring advancement in research and development (R&D) and teaching. Various strategies and plans have been mapped out in tandem with the university‟s endeavour to spur and harness competency in R&D, science and technology, and capacity to innovate.
    [Show full text]
  • Treatment on Gouty Arthritis Animal Model
    Journal of Applied Pharmaceutical Science Vol. 7 (07), pp. 202-207, July, 2017 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2017.70729 ISSN 2231-3354 Anti-inflammatory and anti-hyperuricemia properties of chicken feet cartilage: treatment on gouty arthritis animal model Tri Dewanti Widyaningsih*, Widya Dwi Rukmi Putri, Erni Sofia Murtini, Nia Rochmawati, Debora Nangin Department of Agricultural Product Technology, Faculty of Agricultural Technology, Brawijaya University, Malang 65145, Indonesia. ABSTRACT ARTICLE INFO Article history: Gout is a form of inflammatory arthritis caused by the deposition of uric acid. The therapeutic approach to gout Received on: 22/03/2017 is mainly divided by the treatment of inflammation and the management of serum urate level. This study aim to Accepted on: 13/05/2017 investigate whether chondroitin sulfate (CS) and glucosamine in chicken feet cartilage powder (CFE) and Available online: 30/07/2017 aqueous extract (AE) are able to decrease serum urate level and inflammation in animal model of gouty arthritis. CFE and AE were evaluated in vitro for xanthine oxidase (XO) inhibition. The anti-hyperuricemic activity and Key words: liver XO inhibition were evaluated in vivo on oxonate-induced hyperuricemia rats. Anti-inflammatory property Chicken feet cartilage, gout, was also determined on monosodium urate (MSU) crystal-induced paw edema model. CFE and AE hyperuricemia, monosodium supplementation showed urate-lowering activity. However, both treatments were not able to inhibit in vitro and urate, inflammation. in vivo XO activity. In MSU crystal-induced mice, the levels of paw swelling and lipid peroxidation were increased; in addition, a decrease in the activities of SOD and changes in the expression of CD11b+TNF-α and CD11b+IL-6 of the spleen were demonstrated.
    [Show full text]
  • Evaluation of Herbal Medicinal Products
    Evaluation of Herbal Medicinal Products Evaluation of Herbal Medicinal Products Perspectives on quality, safety and efficacy Edited by Pulok K Mukherjee Director, School of Natural Product Studies, Jadavpur University, Kolkata, India Peter J Houghton Emeritus Professor in Pharmacognosy, Pharmaceutical Sciences Division, King’s College London, London, UK London • Chicago Published by the Pharmaceutical Press An imprint of RPS Publishing 1 Lambeth High Street, London SE1 7JN, UK 100 South Atkinson Road, Suite 200, Grayslake, IL 60030-7820, USA © Pharmaceutical Press 2009 is a trade mark of RPS Publishing RPS Publishing is the publishing organisation of the Royal Pharmaceutical Society of Great Britain First published 2009 Typeset by J&L Composition, Scarborough, North Yorkshire Printed in Great Britain by Cromwell Press Group, Trowbridge ISBN 978 0 85369 751 0 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the prior written permission of the copyright holder. The publisher makes no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. The right of Pulok K Mukherjee and Peter J Houghton to be identified as the editors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988. A catalogue record for this book is available from the British Library
    [Show full text]
  • A Review of Phytotherapy of Gout: Perspective of New Pharmacological Treatments
    REVIEW Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People’s Republic of China A review of phytotherapy of gout: perspective of new pharmacological treatments X. Ling, W. Bochu Received April 9, 2013, accepted July 5, 2013 Professor Wang Bochu, College of Bioengineering, Chongqing University, Chongqing, People’s Republic of China [email protected] Pharmazie 69: 243–256 (2014) doi: 10.1691/ph.2014.3642 The purpose of this review article is to outline plants currently used and those with high promise for the development of anti-gout products. All relevant literature databases were searched up to 25 March 2013. The search terms were ‘gout’, ‘gouty arthritis’, ‘hyperuricemia’, ‘uric acid’, ‘xanthine oxidase (XO) inhibitor’, ‘uricosuric’, ‘urate transporter 1(URAT1)’ and ‘glucose transporter 9 (GLUT9)’. Herbal keywords included ‘herbal medicine’, ‘medicinal plant’, ‘natural products’, ‘phytomedicine’ and ‘phytotherapy’. ‘anti- inflammatory effect’ combined with the words ‘interleukin-6 (IL-6)’, ‘interleukin-8 (IL-8)’, ‘interleukin-1␤ (IL-1␤)’, and ‘tumor necrosis factor ␣ (TNF-␣)’. XO inhibitory effect, uricosuric action, and anti-inflammatory effects were the key outcomes. Numerous agents derived from plants have anti-gout potential. In in vitro studies, flavonoids, alkaloids, essential oils, phenolic compounds, tannins, iridoid glucosides, and coumarins show the potential of anti-gout effects by their XO inhibitory action, while lignans, triterpenoids and xanthophyll are acting through their anti-inflammatory effects. In animal studies, essential oils, lignans, and tannins show dual effects including reduction of uric acid generation and uricosuric action. Alkaloids reveal inhibit uric acid generation, show anti-inflammatory effects, or a combination of the two.
    [Show full text]
  • Cinnamon, a Promising Prospect Towards Alzheimer's Disease
    Pharmacological Research 2017 Cinnamon, a promising prospect towards Alzheimer’s disease Saeideh Momtazb,a, Shokoufeh Hassania,c, Fazlullah Khana,c,d, Mojtaba Ziaeeb,e, a,c* Mohammad Abdollahi a Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran b Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran c Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran d International Campus, Tehran University of Medical Sciences (IC-UMS) e Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran * Corresponding author Mohammad Abdollahi, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. Tel/Fax: +98-21-66959104 E-mail Address: [email protected] or [email protected] (M. Abdollahi) Page 1 of 68 Pharmacological Research 2017 Table of Contents 1. Introduction 2. Cinnamon 3. Cinnamon and neurocognitive performance 4. Brain localization of cinnamon 5. Cinnamon and cellular pathways in AD 5.1. Cinnamon and oxidative impairments 5.2. Cinnamon and pro-inflammatory function 6. Effects of cinnamon in other pathophysiological conditions 6.1. Cinnamon, AD and endothelial functions 6.2. Cinnamon, AD and diabetes 7. Cinnamon; bioavailability and clinical application in neurodegenerative disorders Cinnamon, AD and epigenetics, a promising prospect 8. Conclusion 9. References Page 2
    [Show full text]
  • DKB114, a Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J
    nutrients Article DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion Young-Sil Lee 1, Seung-Hyung Kim 2 , Heung Joo Yuk 1 and Dong-Seon Kim 1,* 1 Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea; [email protected] (Y.-S.L.); [email protected] (H.J.Y.) 2 Institute of Traditional Medicine and Bioscience, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Korea; [email protected] * Correspondence: [email protected]; Tel.: +82-42-868-9639 Received: 30 August 2018; Accepted: 25 September 2018; Published: 28 September 2018 Abstract: Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal uric acid excretion. Furthermore, it inhibited the activity of xanthine oxidase (XOD) in vitro and in the liver in addition to reducing hepatic uric acid production. DKB114 decreased cellular uric acid uptake in oocytes and HEK293 cells expressing human urate transporter (hURAT)1 and decreased the protein expression levels of urate transporters, URAT1, and glucose transporter, GLUT9, associated with the reabsorption of uric acid in the kidney.
    [Show full text]
  • Antileukemic Activity of Lignans and Phenylpropanoids of Cinnamomum Parthenoxylon
    Bioorganic & Medicinal Chemistry Letters 26 (2016) 761–764 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon Morina Adfa a, Rizki Rahmad a, Masayuki Ninomiya b, Salprima Yudha S. a, Kaori Tanaka c,d, ⇑ Mamoru Koketsu b, a Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bengkulu University, Jalan Raya W.R. Supratman, Kandang Limun, Bengkulu 38371, Indonesia b Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan c Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan d United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan article info abstract Article history: In this study, we evaluated the in vitro cytotoxicity of fractions and isolated constituents from Received 28 September 2015 Cinnamomum parthenoxylon woods against human leukemia HL-60 and U937 cells. The n-Hex, EtOAc, Revised 13 December 2015 and MeOH–H2O fractions of the woods inhibited cell proliferation in both cell lines. Our phytochemical Accepted 29 December 2015 investigation of the n-Hex and EtOAc fractions led to the isolation of lignans and phenylpropanoids, Available online 30 December 2015 whose chemical structures were confirmed by spectroscopic analyses. All isolated compounds were eval- uated for their in vitro antileukemic activity; especially, hinokinin and cubebin exhibited strong inhibi- Keywords: tion toward U937 cell proliferation. Morphological observation indicated that these cytotoxic actions Cinnamomum parthenoxylon were mediated by apoptosis.
    [Show full text]
  • Pharmacological Properties and Their Medicinal Uses of Cinnamomum: a Review Sanjay Kumara, Reshma Kumarib and Shailja Mishrab Adepartment of Botany, Govt
    Review Pharmacological properties and their medicinal uses of Cinnamomum: a review Sanjay Kumara, Reshma Kumarib and Shailja Mishrab aDepartment of Botany, Govt. P. G. College, Bageshwar, Uttarakhand, India and bDepartment of Botany & Microbiology, Gurukul Kangri University, Haridwar, India Keywords Abstract antimicrobial; cinnamon; ethnopharmacology; phytochemical Objectives Cinnamomum (Family Lauraceae) is traditionally used for compounds; traditional use flavouring food and in pharmaceutical preparations against various ailments. Detailed literature on the ethnobotanical and pharmacological properties of Correspondence Cinnamomum is segregated and not present in well-documented form. In Reshma Kumari, Department of Botany & the present review, we have been trying to gather its detailed medicinal as Microbiology, Gurukul Kangri University, Haridwar 249404, India. well as pharmacological properties. The ethnobotanical and pharmacological E-mail: [email protected] properties of Cinnamomum were collected by searching several scientific databases, that is PubMed, Elsevier, Google Scholar, Science Direct and Received April 28, 2019 Scopus. Accepted September 14, 2019 Key findings The plant extracts have been reported to possess astringent, warm- ing stimulant, carminative, blood purifier, digestive, antiseptic, antifungal, antivi- doi: 10.1111/jphp.13173 ral, antibacterial, antioxidant, anti-inflammatory and immunomodulatory properties and also help to reduce cholesterol and blood sugar levels. A wide range of phytochemical compounds including
    [Show full text]
  • DNA Barcoding Cinnamomum Osmophloeum Kaneh. Based on the Partial Non-Coding ITS2 Region of Ribosomal Genes
    128 Journal of Food and Drug Analysis, Vol. 18, No. 2, 2010, Pages 128-135 藥物食品分析 第十八卷 第二期 DNA Barcoding Cinnamomum osmophloeum Kaneh. Based on the Partial Non-Coding ITS2 Region of Ribosomal Genes SHIH-CHIEH LEE1*, SHU-JIAU CHIOU2,3, JUI-HUNG YEN2, TSAI-YUN LIN3, KUN-TING HSIEH4 AND JENG-CHUAN YANG5 1. Department of Bioindustry Technology, Da-Yeh University, Changhua 51591, Taiwan, R.O.C. 2. Biomedical Engineering Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan, R.O.C. 3. Department of Life Science and Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30013, Taiwan, R.O.C. 4. Department of Molecular Biotechnology, Da-Yeh University, Changhua 51591, Taiwan, R.O.C. 5. Department of Forestry and Nature Conservation, Chinese Culture University, Taipei 11114, Taiwan, R.O.C. (Received: April 24, 2009; Accepted: January 25, 2010) ABSTRACT This paper investigated the DNA barcoding of indigenous cinnamon. The essential oil composition of leaves and the partial non-coding internal transcribed spacer (ITS2) region of ribosomal genes from indigenous cinnamon plants (Cinnamomum osmo- phloeum Kaneh.) were investigated. Leaf essential oils from seven geographical strains of C. osmophloeum Kaneh. were obtained by hydrodistillation and characterized by gas chromatography-mass spectrometry. Six chemotypes, including cinnamalde- hyde, cinnamaldehyde/cinnamyl acetate, cinnamyl acetate, linalool, camphor and mixed, were identified. Seven representative geographical strains were further used to study their genetic diversity based on the partial ITS2 region using PCR amplification and DNA sequencing to evaluate the region’s use in the application of DNA barcoding C. osmophloeum Kaneh. A phylogenetic tree was constructed using UPGMA clustering method.
    [Show full text]
  • Effects of Cinnamon (Cinnamomum Spp.) in Dentistry
    molecules Review Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review Spartak Yanakiev Medical College Y. Filaretova, Medical University—Sofia, Yordanka Filaretova Street 3, 1000 Sofia, Bulgaria; [email protected]fia.bg; Tel.: +35-98-8644-5108 Received: 26 July 2020; Accepted: 11 September 2020; Published: 12 September 2020 Abstract: Dental medicine is one of the fields of medicine where the most common pathologies are of bacterial and fungal origins. This review is mainly focused on the antimicrobial effects of cinnamon essential oil (EO), cinnamon extracts, and pure compounds against different oral pathogens and the oral biofilm and the possible effects on soft mouth tissue. Basic information is provided about cinnamon, as is a review of its antimicrobial properties against the most common microorganisms causing dental caries, endodontic and periodontal lesions, and candidiasis. Cinnamon EO, cinnamon extracts, and pure compounds show significant antimicrobial activities against oral pathogens and could be beneficial in caries and periodontal disease prevention, endodontics, and candidiasis treatment. Keywords: cinnamon essential oil; dentistry; oral pathogens; oral biofilm; candida; antimicrobial effect; dental caries; endopathogens; cinnamaldehyde; eugenol 1. Introduction Dental medicine is one of the fields of medicine where the most common pathologies are of bacterial and fungal origins. Widely spread diseases like dental caries, periodontal disease, and endodontic lesions are caused by well-known bacterial and fungal pathogens: Streptococcus mutans, Streptococcus salivarius, Streptococcus sanguinis, Porfiromonas gingivalis, Prevotella intermedia, Actinobacilus actinomycetemcomitans, Enterococcus faecalis, Candida albicans, etc. [1]. Preventive medicine relies mostly upon reducing the bacterial biofilm via oral hygiene. The most often used active ingredients in mouth rinses and toothpastes are chlorhexidine, hyaluronic acid, and fluorides.
    [Show full text]
  • The Hemiptera-Sternorrhyncha (Insecta) of Hong Kong, China—An Annotated Inventory Citing Voucher Specimens and Published Records
    Zootaxa 2847: 1–122 (2011) ISSN 1175-5326 (print edition) www.mapress.com/zootaxa/ Monograph ZOOTAXA Copyright © 2011 · Magnolia Press ISSN 1175-5334 (online edition) ZOOTAXA 2847 The Hemiptera-Sternorrhyncha (Insecta) of Hong Kong, China—an annotated inventory citing voucher specimens and published records JON H. MARTIN1 & CLIVE S.K. LAU2 1Corresponding author, Department of Entomology, Natural History Museum, Cromwell Road, London SW7 5BD, U.K., e-mail [email protected] 2 Agriculture, Fisheries and Conservation Department, Cheung Sha Wan Road Government Offices, 303 Cheung Sha Wan Road, Kowloon, Hong Kong, e-mail [email protected] Magnolia Press Auckland, New Zealand Accepted by C. Hodgson: 17 Jan 2011; published: 29 Apr. 2011 JON H. MARTIN & CLIVE S.K. LAU The Hemiptera-Sternorrhyncha (Insecta) of Hong Kong, China—an annotated inventory citing voucher specimens and published records (Zootaxa 2847) 122 pp.; 30 cm. 29 Apr. 2011 ISBN 978-1-86977-705-0 (paperback) ISBN 978-1-86977-706-7 (Online edition) FIRST PUBLISHED IN 2011 BY Magnolia Press P.O. Box 41-383 Auckland 1346 New Zealand e-mail: [email protected] http://www.mapress.com/zootaxa/ © 2011 Magnolia Press All rights reserved. No part of this publication may be reproduced, stored, transmitted or disseminated, in any form, or by any means, without prior written permission from the publisher, to whom all requests to reproduce copyright material should be directed in writing. This authorization does not extend to any other kind of copying, by any means, in any form, and for any purpose other than private research use.
    [Show full text]
  • A Review of Phytotherapy of Gout: Perspective of New Pharmacological Treatments
    REVIEW Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People’s Republic of China A review of phytotherapy of gout: perspective of new pharmacological treatments X. Ling, W. Bochu Received April 9, 2013, accepted July 5, 2013 Professor Wang Bochu, College of Bioengineering, Chongqing University, Chongqing, People’s Republic of China [email protected] Pharmazie 69: 243–256 (2014) doi: 10.1691/ph.2014.3642 The purpose of this review article is to outline plants currently used and those with high promise for the development of anti-gout products. All relevant literature databases were searched up to 25 March 2013. The search terms were ‘gout’, ‘gouty arthritis’, ‘hyperuricemia’, ‘uric acid’, ‘xanthine oxidase (XO) inhibitor’, ‘uricosuric’, ‘urate transporter 1(URAT1)’ and ‘glucose transporter 9 (GLUT9)’. Herbal keywords included ‘herbal medicine’, ‘medicinal plant’, ‘natural products’, ‘phytomedicine’ and ‘phytotherapy’. ‘anti- inflammatory effect’ combined with the words ‘interleukin-6 (IL-6)’, ‘interleukin-8 (IL-8)’, ‘interleukin-1␤ (IL-1␤)’, and ‘tumor necrosis factor ␣ (TNF-␣)’. XO inhibitory effect, uricosuric action, and anti-inflammatory effects were the key outcomes. Numerous agents derived from plants have anti-gout potential. In in vitro studies, flavonoids, alkaloids, essential oils, phenolic compounds, tannins, iridoid glucosides, and coumarins show the potential of anti-gout effects by their XO inhibitory action, while lignans, triterpenoids and xanthophyll are acting through their anti-inflammatory effects. In animal studies, essential oils, lignans, and tannins show dual effects including reduction of uric acid generation and uricosuric action. Alkaloids reveal inhibit uric acid generation, show anti-inflammatory effects, or a combination of the two.
    [Show full text]