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Thai Male a a a Mai Mali Malta Ma Ma Mitte THAI MALE A A A US009901551B2MAI MALI MALTA MA MA MITTE (12 ) United States Patent (10 ) Patent No. : US 9 , 901, 551 B2 Baron et al. ( 45 ) Date of Patent: Feb . 27, 2018 ( 54 ) CHEMOSENSORY RECEPTOR 5 ,424 ,286 A 6 / 1995 Eng LIGAND - BASED THERAPIES 5 ,436 , 128 A 7 / 1995 Harpold et al. y@ 5 , 451, 409 A 9 / 1995 Rencher et al . ( 75 ) Inventors : Alain Baron , San Diego , CA (US ); 5 , 582 , 837 A 12 / 1996 Shell Martin R . Brown, Coronado , CA (US ) ; 5 ,589 , 194 A 12 / 1996 Tsuei et al . 5 ,591 , 767 A 1 / 1997 Mohr Christopher R . J . Jones , San Diego , 5 ,603 , 957 A 2 / 1997 Burguiere et al . CA (US ) 5 ,639 ,476 A 6 / 1997 Oshlack et al. @(73 ) Assignee : AMBRA BIOSCIENCE LLC , San 5 ,691 , 188 A 11/ 1997 Pausch et al. Diego , CA (US ) 5 ,733 , 566 A 3 / 1998 Lewis 5 ,753 , 253 A 5 / 1998 Meyer @( * ) Notice : Subject to any disclaimer , the term of this 5 ,783 ,212 A 7 / 1998 Fassihi et al . patent is extended or adjusted under 35 5 , 846 , 566 A 12/ 1998 Burguiere et al . U . S . C . 154 ( b ) by 682 days . 5 ,874 ,243 A 2 / 1999 Macina et al . 5 ,945 , 125 A 8 / 1999 Kim 5 , 952 ,021 A 9 / 1999 Santus et al. (21 ) Appl . No. : 12 /763 , 926 5 , 972 ,389 A 10 / 1999 Shell et al. ( 22 ) Filed : Apr . 20, 2010 6 ,022 , 562 A 2 / 2000 Autant et al. 6 ,090 ,411 A 7 / 2000 Pillay et al . (65 ) Prior Publication Data 6 , 120 , 803 A 9 / 2000 Wong et al. 6 , 210 , 710 B1 4 / 2001 Skinner US 2010 /0267643 A1 Oct. 21, 2010 6 , 217 , 903 B1 4 / 2001 Skinner 6 , 245 , 356 B1 6 / 2001 Baichwal Related U . S . Application Data 6 , 267 , 988 B1 7 / 2001 Meyer 6 ,487 ,445 B1 11/ 2002 Serita et al . (60 ) Provisional application No. 61/ 170 ,657 , filed on Apr. 6 , 530 ,886 B13 / 2003 Ishida et al. 20 , 2009 . 6 ,558 ,708 B1 5 /2003 Lin (51 ) Int . Cl. ( Continued ) A61K 38 / 05 ( 2006 .01 ) FOREIGN PATENT DOCUMENTS A61K 31 / 13 ( 2006 .01 ) CN 1 125 574 A 7 / 1996 A61K 31/ 195 ( 2006 .01 ) CN 100 490 789 C 5 / 2009 A61K 31 /20 ( 2006 .01 ) A61K 31/ 235 ( 2006 .01 ) (Continued ) A61K 31/ 35 ( 2006 .01 ) OTHER PUBLICATIONS A6IK 31/ 352 ( 2006 .01 ) Mezitis et al . Glycemic Effect of a Single High Oral Dose of the A61K 31 / 70 ( 2006 . 01) Novel Sweetener Sucralose in Patients With Diabetes , Sep . 1996 , A61K 38 / 22 ( 2006 . 01 ) 19 ( 9 ) : 1004 - 1005. * A61K 38 / 26 ( 2006 .01 ) Food and Drug Administration , “ Food Additives Permitted for ( 52 ) U . S . CI. Direct Addition to Food for Human Consumption ; Sucralose ” , CPC .. .. A61K 31 / 13 ( 2013 .01 ) ; A61K 31 / 195 Federal Register / vol. 63 , No. 64 / Friday, Apr. 3 , 1998 /Rules and ( 2013 .01 ) ; A61K 31 /20 ( 2013 .01 ) ; A61K Regulations, pp . 16417 - 16433 . * Abdula et at, “ Rebaudioside a Directly Stimulates Insulin Secretion 31/ 235 (2013 .01 ) ; A61K 31/ 35 ( 2013 .01 ) ; from Pancreatic Beta Cells : A Glucose -Dependent Action Via A61K 31 / 352 ( 2013 .01 ) ; A61K 31/ 70 Inhibition of Atp - Sensitive K - Channels .” Diabetes, Obesity & ( 2013. 01 ) ; A61K 38 / 22 ( 2013 .01 ) ; A61K 38 / 26 Metabolism , 2010 . ( 2013 .01 ) Adler et al. , “ A Novel Family of Taste Receptors, ” Cell, 2000 , ( 58 ) Field of Classification Search 100 : 693 - 702 . None Adrian et al ., “ Deoxycholate is an Important Releaser of Peptide Yy See application file for complete search history. and Enteroglucagon From the Human Colon ," Gut, 1993 , 34 ( 9 ) : 1219 - 1224 . Adrian et al . “ Human Distribution and Release of a Putative New ( 56 ) References Cited Gut Hormone, Peptide YY .” Gastroenterology , 1985 , 89 : 1070 1077 . U . S . PATENT DOCUMENTS Altenhofen et al. , " Control of ligand specificity in cyclic nuceiotide 3 ,536 ,809 A 10 / 1970 Applezweig gated channels from rod photoreceptors and olfactory epithelium , ” 3 ,598 , 123 A 8 / 1971 Zaffaroni PNAS USA , 1991, 88 : 9868 - 9872 . 3 , 845 , 770 A 11/ 1974 Theeuwes et al . Anton et al. “ Effects of Stevia , Aspartame and Sucrose on Food 3 ,916 ,899 A 11/ 1975 Theeuwes et al . Intake , Satiety , and Postprandial Glucose and Insulin Levels , " 4 , 008 , 719 A 2 / 1977 Theeuwes et al. Appetite 2010 , 55 :37 -43 . 4 , 036 , 948 A 7 / 1977 Kitamori et al. 4 , 115 , 538 A 9 / 1978 Satoh et al. (Continued ) 4 , 434 , 153 A 2 / 1984 Urquhart et al . Primary Examiner — John Ulm 4 , 844 , 905 A 7 / 1989 Ichikawa et al. (74 ) Attorney , Agent, or Firm — Todd A . Lorenz 4 ,915 , 952 A 4 / 1990 Ayer et al . 5 , 007 ,790 A 4 / 1991 Shell (57 ) ABSTRACT 5 , 059 , 595 A 10 / 1991 Le Grazie Provided herein are compositions and methods for treating 5 ,073 ,543 A 12 / 1991 Marshall et al. diabetes , obesity , and other metabolic diseases , disorders or 5 , 120 , 548 A 6 / 1992 McClelland et al . conditions with chemosensory receptor ligands . Also pro 5 , 135 , 757 A 8 / 1992 Baichwal et al . vided herein are pharmaceutical compositions useful for the 5 , 322 ,697 A 6 / 1994 Meyer 5 , 328 , 942 A 7 / 1994 Akhtar et al . methods of the present invention . 5 ,354 ,556 A 10 / 1994 Sparks et al . 16 Claims, No Drawings US 9 , 901, 551 B2 Page 2 (56 ) References Cited Bourne et al . “ The GTPase Superfamily : A Conservative Switch for Diverse Cell Functions. ” Nature , 1990 , 348 : 125 - 132 . U . S . PATENT DOCUMENTS Brown et al. , “ Ingestion of Diet Soda before a Glucose Load Augments Glucagon - Like Peptide - 1 Secretion ,” Diabetes Care , 6 ,685 ,962 B2 2 /2004 Friedman et al . 2009 , 32 :2184 -2186 . 6 , 815 , 436 B211 / 2004 Hansson et al . Brubaker and Drucker. “ Structure -Function of the Glucagon Recep 6 , 850 , 797 B2 2 / 2005 Kawanishi et al . tor Family of g Protein -Coupled Receptors : The Glucagon , GIP , 6 , 864 , 415 B2 3 / 2005 Koyanagi et al . 7 ,105 , 650 B2 . 9 / 2006 Adler GLP - 1 , and GLP - 2 Receptors ,” Receptors Channels , 2002 , 8 : 179 7 , 812 ,004 B2 10 / 2010 Frippiat et al . 188 . 7 , 883 , 856 B2 2 /2011 Li et al. Buck et al. , “ A Novel Multigene Family May Encode Odorant 2002 /0160424 A1 10 / 2002 Adler et al. Receptors : A Molecular Basis for Odor Recognition , ” Cell , 1991 , 2003/ 0072822 Al 4 /2003 Ribnicky et al . 65: 175 - 187 . 2004 / 0109894 Al 6 / 2004 Shefer et al. Burcelin , et al. , “Glucagon - Like Peptide - 1 and Energy Homeosta 2004 / 0258735 A1 12 / 2004 Van Benthum et al. sis , ” The Journal of Nutrition , 2001 , pp . 2534S - 2538S . 2004 /0258803 Al 12 / 2004 Van Benthurn et al. Burrin et al ., “ Glucagon -Like Peptide 2 : a Nutrient -Responsive Gut 2005 / 0038415 Al 2 / 2005 Rohr et al . Growth Factor, " J Nutrition , 2001 , 131 ( 3 ) :709 . 2005 /0238777 A1 10 /2005 Klingeberg et al. Cani et al . , “ The Role of the Gut Microbiota in Energy Metabolism 2005 /0244810 A111/ 2005 Egan et al . 2007 /0032420 A1 2 / 2007 Polidori et al . and Metabolic Disease , " Current Pharmaceutical Design , 2009 , 2008 /0274215 AL 11/ 2008 Morrow 15 : 1546 - 1558 . 2008 / 0305500 A112 / 2008 Servant et al. Carelli et al . “ Silicone Microspheres for pH -Controlled Gastroin 2008 /0306053 Al 12 / 2008 Tachdjian testinal Drug Delivery .” Int. J . Pharmaceutics, 1999 , 179 :73 - 83 . 2008 /0306076 Al 12 / 2008 Li et al. Chan et al. , “ Peptide Yy Levels Are Elevated after Gastric Bypass 2008 /0306093 Al 12 / 2008 Servant et al. Surgery , ” Obesity , 2006 , 14 ( 2 ) : 194 - 198 . 2008 /0311192 A112 / 2008 West et al . Chandrashekar et al. , “ T2Rs Function as Bitter Taste Receptors, " 2009 / 0062193 AL 3 / 2009 Weyer Cell, 2000 , 100 :703 - 711 . 2009 /0170948 AL 7 / 2009 Niddam -Hildesheim et al. Chandrashekar et al. “ The cells and peripheral representation of 2010 / 0093861 A1 4 / 2010 Hermansen et al . sodium taste in mice .” 2010 Nature 464 ( 7286 ) : 297 - 301 . 2011/ 0045069 AL 2 /2011 Ley et al. Chanoine et al. , “ Glp - 1 and Appetite Responses to a Meal in Lean and Overweight Adolescents Following Exercise ," Obesity , 2008 , FOREIGN PATENT DOCUMENTS 16 :202 - 204 . Chatsudthipong et al . “ Stevioside and Related Compounds : Thera EP 0867508 A2 9 / 1998 peutic Benefits Beyond Sweetness .” Pharmacology & Therapeu WO - 2010 -027498 3 / 1920 WO WO - 1992 - 17585 A1 10 / 1992 tics , 2009 , 121 :41 - 54 . WO WO - 1993 - 18755 A1 9 / 1993 Chen et al. “ Bitter Stimuli Induce Ca2 + Signaling and Cck Release W0 WO - 1995 - 18140 A1 7 / 1995 in Enteroendocrine Ste - 1 Cells : Role of L - Type Voltage Sensitive WO WO 96 / 01623 A1 1 / 1996 Ca2 + Channels .” American Journal at Physiology, Cell Physiology , WO WO - 1996 - 26718 A2 9 / 1996 2006 , 291 : C726 - C739 . WO WO - 1997 - 17444 A2 5 / 1997 Chen et al ., “Gut Expression and Regulation of FAT /CD36 :Possible WO WO - 1997 - 18814 Al 5 / 1997 Role in Fatty Acid Transport in Rat Enterocytes ,” Am J Physiol WO WO - 1998 - 55107 Al 12 / 1998 Endocrinol Metab , 2001, 281 ( 5 ) : E916 - E923 . WO WO - 1999 -67282 A2 12 / 1999 Christiansen et al ., “ Discovery of Potent and Selective Agonists for W0 WO - 2001 - 23341 4 /2001 the Free Fatty Acid Receptor I (Ffa ( 1 ) /Gpr40 ) , a Potential Target for WO WO 2005 /046580 A3 5 / 2005 the Treatment of Type II Diabetes, ” Journal of Medicinal Chemis WO WO 2006 /119389 A2 11 / 2006 try , 2008, 51 : 7061- 7064 . WO WO 2007 /085593 AL 8 / 2007 WO WO - 2008 -008224 1 / 2008 Claustre et al ., “ Stimulatory effect of ß -adrenergic agonists on ileal WO WO 2008 /057968 A2 5 /2008 L cell secretion and modulation by a - adrenergic activation , " J WO WO 2008 / 154221 A2 12 / 2008 Endocrin , 1999 , 162 : 271 - 278 .
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