THAI MALE A A A US009901551B2MAI MALI MALTA MA MA MITTE (12 ) United States Patent (10 ) Patent No. : US 9 , 901, 551 B2 Baron et al. ( 45 ) Date of Patent: Feb . 27, 2018 ( 54 ) CHEMOSENSORY RECEPTOR 5 ,424 ,286 A 6 / 1995 Eng LIGAND - BASED THERAPIES 5 ,436 , 128 A 7 / 1995 Harpold et al. y@ 5 , 451, 409 A 9 / 1995 Rencher et al . ( 75 ) Inventors : Alain Baron , San Diego , CA (US ); 5 , 582 , 837 A 12 / 1996 Shell Martin R . Brown, Coronado , CA (US ) ; 5 ,589 , 194 A 12 / 1996 Tsuei et al . 5 ,591 , 767 A 1 / 1997 Mohr Christopher R . J . Jones , San Diego , 5 ,603 , 957 A 2 / 1997 Burguiere et al . CA (US ) 5 ,639 ,476 A 6 / 1997 Oshlack et al. @(73 ) Assignee : AMBRA BIOSCIENCE LLC , San 5 ,691 , 188 A 11/ 1997 Pausch et al. 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A61K 31 / 13 ( 2013 .01 ) ; A61K 31 / 195 Federal Register / vol. 63 , No. 64 / Friday, Apr. 3 , 1998 /Rules and ( 2013 .01 ) ; A61K 31 /20 ( 2013 .01 ) ; A61K Regulations, pp . 16417 - 16433 . * Abdula et at, “ Rebaudioside a Directly Stimulates Insulin Secretion 31/ 235 (2013 .01 ) ; A61K 31/ 35 ( 2013 .01 ) ; from Pancreatic Beta Cells : A Glucose -Dependent Action Via A61K 31 / 352 ( 2013 .01 ) ; A61K 31/ 70 Inhibition of Atp - Sensitive K - Channels .” Diabetes, Obesity & ( 2013. 01 ) ; A61K 38 / 22 ( 2013 .01 ) ; A61K 38 / 26 Metabolism , 2010 . ( 2013 .01 ) Adler et al. , “ A Novel Family of Taste Receptors, ” Cell, 2000 , ( 58 ) Field of Classification Search 100 : 693 - 702 . None Adrian et al ., “ Deoxycholate is an Important Releaser of Peptide Yy See application file for complete search history. and Enteroglucagon From the Human Colon ," Gut, 1993 , 34 ( 9 ) : 1219 - 1224 . 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