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Preface xi Chapter 1 The HSV-2 Gene ICP10PK: A Future in the 1 Therapy of Neurodegeneration Laure Aurelian Chapter 2 What Doesn’t Belong and Why: a Saga of 23 Latency Associated Proteins Elaborated by Varicella Zoster Matthew S. Walters, Christos A. Kyratsous, Christina L. Stallings, Octavian Lungu and Saul J. Silverstein Chapter 3 Selected Aspects of Herpesvirus DNA Replication, 59 Cleavage/Packaging and the Development and Use of Viral Amplicon Vectors Niza Frenkel, Ronen Borenstein and Haim Zeigerman Chapter 4 Chromatin Structure of the 1 93 Genome During Lytic and Latent Infection Anna R. Cliffe and David M. Knipe Chapter 5 The Proboscivirus Genus: Hemorrhagic Disease 123 Caused by Elephant Endotheliotropic Herpesviruses Jian-Chao Zong, Erin Latimer, Sarah Y. Heaggans, Laura K. Richman and Gary S. Hayward

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Chapter 6 A Molecular Mass Gradient is the Key Parameter 155 of the Genetic Code Organization Felix Filatov Chapter 7 From Latent Herpes to Persistent Bornavirus 169 Dedicated to Bernard Roizman Hanns Ludwig and Liv Bode Chapter 8 Virus Infections and Development 187 of Cervical Cancer Bodil Norrild Chapter 9 Control of Cell Death Pathways 201 A. Louise McCormick and Edward S. Mocarski Chapter 10 Herpesviruses as Oncolytic Agents 223 Gabriella Campadelli-Fiume, Laura Menotti, Grace Zhou, Carla De Giovanni, Patrizia Nanni and Pier Luigi Lollini Chapter 11 Role of Cellular MicroRNAs During Human 251 Cytomegalovirus Infection Kavitha Dhuruvasan, Geetha Sivasubramanian and Philip E. Pellett Chapter 12 Burkitt’s Lymphoma and EBV — The Role 273 of LMP2A Kathryn T. Bieging and Richard Longnecker Chapter 13 Replicative Herpes Simplex Virus Vectors for 303 Therapy of Autoimmune Central Nervous System Disease Veijo Hukkanen, Michaela Nygårdas and Eeva Broberg Chapter 14 The Herpes Simplex Virus DNA Packaging Machine 329 Joel D. Baines Chapter 15 Post-Transcriptional Gene Regulation: Role of the 343 Polypyrimidine Tract-Binding Protein (PTB) and Associated Factors Maria Grazia Romanelli and Erica Diani b1227_FM.qxd 2/15/2012 10:12 AM Page ix

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Chapter 16 Nucleotidylation to Oncoapoptosis 361 John A. Blaho, Martine Aubert, Kathy Bae, Brooke Baker, Jenny Balderama, Renee Baranin, Monica Bhanot, Amanda Blouin, Robert N. Bowles, Isabella Chi, F. Natalie W. Chirimuuta, Christopher R. Cotter, Elisabeth Gennis, Laura Gillim, Margot L. Goodkin, Kristin Ingvarsdottir, Andrea E. Ireland, Leah Kang, Surinder Kaul, Anna Kotsakis, Rachel M. Kraft, Renzo C. Lambardozzi, Maria R. Lopez, Fatima Manzoor, Kerryn A. Mortimer, Elise R. Morton, Marie L. Nguyen, Jennifer M. O’Toole, Jason Paragas, Kristen C. Pena, Lisa E. Pomeranz, Deleen Sabbah, Christine M. Sanfilippo, Louis R. Serico, Elisabeth F.M. Schlegel, Chintal Shah, Cecylia Stabrawa, Dennis Vega, Sandra Winstersteller, Jamie C. Yedowitz and C. Susan Zong Chapter 17 Geographic Distribution and High Frequency 407

of Herpes Simplex Virus Type 1 BgKL Variant in Orolabial/Cutaneous Infections: The HSV-1 Variant Dispersion-Replacement Model Kazuo Yanagi Chapter 18 Virucidal Ability of Arginine and its Possible 435 Application as an Antiherpetic Agent Keiko Ikeda, Hisashi Yamasaki, Sawako Minami, Takeshi Naito, Hiroshi Irie, Tsutomu Arakawa and A. Hajime Koyama Chapter 19 Genetic Analyses of Human Cytomegalovirus 451 Towne Strain by Deletion Mutagenesis Edward Yang, Paul J. Rider and Fenyong Liu Chapter 20 Angiogenic and Oncogenic Alterations of 481 Endothelial Cells by KSHV Valerie A. Morris, Terri Dimaio, Almira S. Punjabi and Michael Lagunoff b1227_FM.qxd 2/15/2012 10:12 AM Page x

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Chapter 21 Decoding Neural Circuitry with Optogenetics: 515 Applications for Epilepsy Philip Barish, Svetlana Kantorovich, Paul Carney and William Ogle Chapter 22 From Psychosocial Stress to Herpes Simplex 535 Infection: A Sequence of Coordinated Events Regulated in a Cascade Fashion Rosario Leopardi and Alessandro Bartolomucci Chapter 23 Herpes Simplex Viruses and Interferon Responses 561 Yijie Ma and Bin He Chapter 24 Herpes Virus Genes and Gene Regulation: Insights 579 from Systems Biology Joanne Trgovcich Chapter 25 Viral Manipulation of Cellular Metabolic Signal 611 Transduction Pathways Joshua Munger Chapter 26 How Herpesviruses and Cells Tussle to Control 631 Autophagy Audrey Esclatine Epilogue — Kovler Poems 667 Susanna Rudofsky