Chapter 2: Gestational Age-Dependent Changes in Gene Expression of Metabolic Enzymes and Transporters in Pregnant Mice

This work was previously published by Shuster et al., in Drug Metabolism and Disposition 41:332–342, in February 2013. Reprinted with permission of the American Society for Pharmacology and Experimental Therapeutics.

Copyright © 2013 by the American Society for Pharmacology and Experimental Therapeutics.

Supplemental Table 2: Multiple hypothesis correction in the maternal liver on gd 10

Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1 10424383 5.3 39.3 11.3 2.77E-14 0.00% 2 10423030 Prlr 1.0 2.0 12.0 5.00E-11 0.00% 3 10422822 Lifr 1.0 2.1 12.8 1.39E-10 0.00% 4 10594251 Kif23 1.0 2.0 5.8 1.88E-09 0.00% 5 10507143 Cyp4a12a -2.0 0.3 5.5 5.01E-09 0.00% 6 10507152 Cyp4a12b -1.7 0.3 5.1 7.90E-09 0.00% 7 10606989 Tsc22d3 -1.2 0.4 9.2 1.61E-08 0.00% 8 10466624 Aldh1a7 1.4 2.7 11.9 3.22E-08 0.01% 9 10570280 F7 0.7 1.7 10.9 3.55E-08 0.01% 10 10589099 Ip6k2 -1.4 0.4 8.5 4.06E-08 0.01% 11 10350159 Lad1 0.8 1.8 7.3 4.27E-08 0.01% 12 10434845 Il1rap -0.7 0.6 10.0 5.27E-08 0.01% 13 10579406 Arrdc2 -1.0 0.5 7.0 6.58E-08 0.01% 14 10445251 Gpr110 -1.3 0.4 5.6 6.71E-08 0.01% 15 10530615 Ociad2 -1.0 0.5 7.1 1.08E-07 0.02% 16 10552613 Klk1b4 1.7 3.3 8.1 1.28E-07 0.02% 17 10574087 Herpud1 -1.0 0.5 11.7 1.39E-07 0.02% 18 10430770 Tob2 -0.7 0.6 6.6 1.52E-07 0.02% 19 10503259 Trp53inp1 -1.1 0.5 9.8 1.93E-07 0.02% 20 10497372 Gm5150 1.2 2.4 6.8 2.65E-07 0.03% 21 10608710 Ahsp 1.1 2.2 5.3 3.06E-07 0.03% 22 10425763 Cyp2d9 -0.9 0.5 6.8 3.32E-07 0.03% 23 10466210 Ms4a6d 1.2 2.3 7.3 3.43E-07 0.03% 24 10446656 Lpin2 -1.1 0.5 10.1 5.41E-07 0.05% 25 10415319 Irf9 0.5 1.4 8.6 5.51E-07 0.05% 26 10501164 Csf1 1.0 2.1 7.9 5.93E-07 0.05% 27 10572897 Hmox1 0.9 1.9 9.0 6.45E-07 0.05% 28 10498367 P2ry13 0.8 1.8 8.2 6.65E-07 0.05% 29 10394674 Socs2 1.6 3.0 11.4 6.68E-07 0.05% 30 10402347 Ifi27l2a 0.6 1.5 6.1 7.48E-07 0.05%

Page 1 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

31 10381474 Arl4d -2.0 0.2 7.0 9.04E-07 0.06% 32 10554574 Tm6sf1 0.6 1.5 7.7 9.39E-07 0.06% 33 10415052 Mmp14 0.8 1.8 8.8 9.50E-07 0.06% 34 10377763 Asgr2 0.5 1.4 11.5 1.02E-06 0.06% 35 10603860 Cfp 0.8 1.8 8.7 1.02E-06 0.06% 36 10371578 Ascl1 4.8 28.7 9.5 1.04E-06 0.06% 37 10541034 Anubl1 -1.1 0.5 8.3 1.05E-06 0.06% 38 10541564 Clec4a3 1.0 2.0 7.3 1.11E-06 0.06% 39 10450038 Angptl4 -1.2 0.5 9.5 1.14E-06 0.06% 40 10512251 AI464131 0.9 1.8 9.4 1.23E-06 0.07% 41 10442098 Fpr3 0.6 1.5 5.4 1.24E-06 0.07% 42 10434778 Rtp4 1.0 1.9 8.3 1.32E-06 0.07% 43 10477250 Hck 0.5 1.4 6.9 1.32E-06 0.07% 44 10392839 Cd300e 0.7 1.6 7.6 1.44E-06 0.07% 45 10378572 Tlcd2 -1.0 0.5 10.2 1.45E-06 0.07% 46 10541410 Mug1 -0.9 0.5 12.4 1.69E-06 0.08% 47 10541448 Mug-ps1 -0.8 0.6 12.2 1.71E-06 0.08% 48 10533198 Oas2 0.6 1.5 6.8 1.71E-06 0.08% 49 10451039 Slc25a27 -0.5 0.7 6.6 1.72E-06 0.08% 50 10388958 Evi2a 0.8 1.7 6.6 1.78E-06 0.08% 51 10478890 Cebpb -0.8 0.6 8.3 1.84E-06 0.08% 52 10387536 Cd68 0.9 1.8 8.3 1.86E-06 0.08% 53 10566358 Trim30a 0.7 1.6 7.9 1.90E-06 0.08% 54 10338994 -0.8 0.6 8.9 1.96E-06 0.08% 55 10441361 Tiam2 0.7 1.6 6.1 1.98E-06 0.08% 56 10396712 Fut8 0.9 1.8 7.6 2.11E-06 0.08% 57 10445758 Treml4 0.9 1.9 8.1 2.17E-06 0.08% 58 10573054 Gypa 0.7 1.6 4.3 2.21E-06 0.08% 59 10467400 Cyp2c54 -0.6 0.7 11.6 2.27E-06 0.08% 60 10458589 Prelid2 1.3 2.5 8.5 2.38E-06 0.08% 61 10392721 Cpsf4l -1.2 0.4 6.8 2.39E-06 0.08% 62 10463070 Entpd1 0.6 1.5 8.1 2.53E-06 0.09% 63 10476301 Smox 0.5 1.5 7.6 2.57E-06 0.09% 64 10448124 Fpr1 0.9 1.9 7.3 2.94E-06 0.10% 65 10600901 Ar 1.3 2.5 8.9 2.97E-06 0.10% 66 10494200 Cdc42se1 0.4 1.3 8.3 3.12E-06 0.10% 67 10523095 Afm 0.3 1.3 11.2 3.23E-06 0.10% 68 10351658 Cd48 0.6 1.5 5.8 3.26E-06 0.10% 69 10507500 Slc6a9 1.1 2.1 11.0 3.57E-06 0.11% 70 10425364 Atf4 0.4 1.3 8.0 3.58E-06 0.11% 71 10372069 Socs2 1.0 2.1 8.3 3.66E-06 0.11%

Page 2 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

72 10491962 Foxo1 -0.7 0.6 8.9 3.71E-06 0.11% 73 10400405 Nfkbia -0.7 0.6 9.2 3.71E-06 0.11% 74 10571467 Pdgfrl -0.5 0.7 5.8 3.93E-06 0.11% 75 10446282 Emr1 0.9 1.9 8.3 4.08E-06 0.12% 76 10585005 Apoa1 -0.4 0.8 13.5 4.46E-06 0.12% 77 10592084 St3gal4 0.6 1.5 10.6 4.46E-06 0.12% 78 10577641 1810011O10Rik -1.5 0.4 9.0 4.66E-06 0.13% 79 10461614 Ms4a6c 1.1 2.2 8.3 4.84E-06 0.13% 80 10439312 Cd86 0.7 1.7 6.2 4.85E-06 0.13% 81 10554240 Isg20 0.8 1.7 7.9 4.98E-06 0.13% 82 10379511 Ccl2 0.5 1.4 6.5 5.05E-06 0.13% 83 10349711 Slc41a1 0.7 1.6 7.1 5.19E-06 0.13% 84 10343431 -0.8 0.6 9.6 5.30E-06 0.13% 85 10544573 Rarres2 -0.7 0.6 11.5 5.36E-06 0.13% 86 10350733 Rgs16 -2.5 0.2 8.8 5.42E-06 0.13% 87 10567580 Igsf6 0.7 1.7 8.2 5.46E-06 0.13% 88 10392440 Slc16a6 1.8 3.4 8.4 5.59E-06 0.14% 89 10582985 Casp1 0.8 1.8 6.1 5.71E-06 0.14% 90 10446253 Vav1 0.6 1.5 6.7 5.77E-06 0.14% 91 10392735 Cdc42ep4 -0.5 0.7 8.5 6.21E-06 0.15% 92 10497481 -1.0 0.5 7.4 6.27E-06 0.15% 93 10384458 Plek 0.7 1.6 6.9 6.37E-06 0.15% 94 10489241 Gm826 -0.6 0.7 8.3 6.64E-06 0.15% 95 10364262 Itgb2 0.5 1.4 7.1 7.03E-06 0.16% 96 10408647 4933417A18Rik 2.3 4.9 9.0 7.10E-06 0.16% 97 10463051 Cyp2c50 -0.7 0.6 11.1 7.15E-06 0.16% 98 10382300 Map2k6 -1.4 0.4 7.7 7.20E-06 0.16% 99 10567564 Cdr2 0.5 1.4 6.4 7.32E-06 0.16% 100 10500335 Fcgr1 0.7 1.6 6.5 7.40E-06 0.16% 101 10541480 Mug-ps1 -0.9 0.6 12.2 8.19E-06 0.17% 102 10560608 Apoc2 0.5 1.4 12.0 8.29E-06 0.17% 103 10427336 Nckap1l 0.7 1.6 8.0 8.49E-06 0.18% 104 10436849 Ifnar1 0.3 1.2 9.1 8.53E-06 0.18% 105 10490989 Cp 0.3 1.2 13.1 8.73E-06 0.18% 106 10485405 Cd44 0.7 1.6 6.9 8.80E-06 0.18% 107 10382106 Gm885 0.7 1.6 5.7 9.03E-06 0.18% 108 10541446 Mug2 -1.2 0.4 9.9 9.20E-06 0.18% 109 10443764 Slc37a1 1.3 2.5 7.9 9.22E-06 0.18% 110 10404059 Hist1h1c 0.7 1.6 9.1 9.45E-06 0.18% 111 10472501 Lass6 0.5 1.5 10.0 9.49E-06 0.18% 112 10402268 Lgmn 0.5 1.4 10.1 9.82E-06 0.19%

Page 3 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

113 10399478 Lpin1 -2.3 0.2 9.6 9.84E-06 0.19% 114 10408850 Nedd9 1.0 2.0 8.2 1.01E-05 0.19% 115 10409737 Agtpbp1 1.1 2.1 9.1 1.01E-05 0.19% 116 10507539 Elovl1 0.6 1.5 10.5 1.04E-05 0.19% 117 10545086 Snca 1.1 2.1 7.1 1.06E-05 0.20% 118 10520388 Rbm33 -0.5 0.7 8.2 1.07E-05 0.20% 119 10347481 Cyp27a1 -0.4 0.7 12.0 1.10E-05 0.20% 120 10549276 Bhlhe41 1.2 2.3 5.8 1.11E-05 0.20% 121 10578352 Fgl1 0.8 1.7 12.9 1.12E-05 0.20% 122 10500565 Hsd3b1 2.1 4.1 7.4 1.14E-05 0.20% 123 10501063 Cd53 0.8 1.7 8.4 1.14E-05 0.20% 124 10473809 Sfpi1 0.8 1.8 7.6 1.14E-05 0.20% 125 10398907 Pld4 0.8 1.7 7.7 1.28E-05 0.22% 126 10481627 Lcn2 2.3 4.8 11.2 1.33E-05 0.23% 127 10541426 Mug2 -0.9 0.5 9.6 1.34E-05 0.23% 128 10582390 Aprt 0.6 1.5 8.4 1.35E-05 0.23% 129 10565852 Rnf169 -0.6 0.7 9.5 1.39E-05 0.23% 130 10438555 Thpo 0.5 1.4 7.8 1.40E-05 0.23% 131 10421128 Adamdec1 0.9 1.8 6.8 1.48E-05 0.24% 132 10402325 Asb2 0.7 1.6 7.4 1.50E-05 0.24% 133 10392808 Cd300ld 0.7 1.6 8.0 1.52E-05 0.25% 134 10432939 Csad -1.0 0.5 7.9 1.54E-05 0.25% 135 10425801 Bik -0.6 0.7 6.5 1.61E-05 0.25% 136 10466622 C730037M02Rik 1.8 3.6 7.0 1.61E-05 0.25% 137 10517508 C1qb 0.9 1.8 10.4 1.63E-05 0.25% 138 10590628 Ccr3 1.0 1.9 7.6 1.64E-05 0.25% 139 10474972 Chac1 -0.7 0.6 7.4 1.65E-05 0.25% 140 10363224 Fabp7 1.3 2.5 8.8 1.66E-05 0.25% 141 10566026 Folr2 0.8 1.7 8.2 1.68E-05 0.26% 142 10347335 Slc11a1 0.5 1.4 8.0 1.69E-05 0.26% 143 10340598 -0.7 0.6 6.0 1.74E-05 0.26% 144 10557591 Itgal 0.6 1.5 7.7 1.76E-05 0.26% 145 10429160 St3gal1 0.6 1.5 10.2 1.78E-05 0.26% 146 10359181 Tor3a 0.5 1.4 6.9 1.81E-05 0.27% 147 10455514 Kcnn2 -0.6 0.7 8.2 1.88E-05 0.28% 148 10439404 Gm4324 0.7 1.6 7.5 1.93E-05 0.28% 149 10343291 -0.6 0.7 7.4 1.97E-05 0.28% 150 10482177 Strbp -0.5 0.7 9.2 1.99E-05 0.28% 151 10517513 C1qc 0.9 1.8 9.2 2.01E-05 0.29% 152 10428012 Ropn1l -0.5 0.7 7.9 2.02E-05 0.29% 153 10415784 Trim13 0.8 1.8 7.1 2.07E-05 0.29%

Page 4 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

154 10562720 Siglece 0.7 1.7 7.4 2.09E-05 0.29% 155 10357261 Marco 0.6 1.5 6.6 2.10E-05 0.29% 156 10377751 Asgr1 0.3 1.2 11.7 2.11E-05 0.29% 157 10350751 Teddm1 -0.4 0.8 5.5 2.15E-05 0.29% 158 10579373 Mast3 -0.5 0.7 8.1 2.15E-05 0.29% 159 10587639 Nt5e 0.7 1.6 10.7 2.16E-05 0.29% 160 10492964 Cd5l 0.9 1.9 9.2 2.19E-05 0.29% 161 10371662 Spic 0.8 1.7 6.6 2.21E-05 0.29% 162 10498978 Lrat -1.0 0.5 8.7 2.21E-05 0.29% 163 10459496 Ccbe1 -0.4 0.8 7.0 2.27E-05 0.30% 164 10602372 Alas2 1.0 2.1 8.4 2.41E-05 0.32% 165 10583753 Gm6484 1.7 3.4 10.4 2.43E-05 0.32% 166 10456071 Csf1r 0.5 1.4 9.1 2.45E-05 0.32% 167 10494271 Ctss 0.8 1.7 8.5 2.50E-05 0.32% 168 10541555 Clec4a1 0.8 1.7 6.8 2.56E-05 0.33% 169 10438738 Bcl6 -0.9 0.6 7.1 2.67E-05 0.34% 170 10394119 Zfp750 -0.7 0.6 7.7 2.67E-05 0.34% 171 10481962 Hc 0.5 1.4 11.1 2.71E-05 0.34% 172 10553354 Nav2 0.5 1.4 7.8 2.79E-05 0.35% 173 10590365 Vipr1 -0.5 0.7 7.9 2.81E-05 0.35% 174 10486112 Bmf -0.8 0.6 6.9 2.84E-05 0.35% 175 10342506 -0.7 0.6 6.9 2.92E-05 0.36% 176 10407053 2810008M24Rik 0.6 1.6 8.2 3.11E-05 0.38% 177 10411373 Hexb 0.4 1.3 9.1 3.15E-05 0.38% 178 10527638 Alox5ap 0.5 1.4 7.0 3.27E-05 0.39% 179 10600852 F630028O10Rik 0.8 1.7 7.2 3.27E-05 0.39% 180 10387821 Alox12 0.5 1.4 5.5 3.29E-05 0.39% 181 10342533 -0.6 0.7 10.9 3.29E-05 0.39% 182 10339269 -0.7 0.6 7.8 3.34E-05 0.39% 183 10440993 Rcan1 1.0 2.0 8.9 3.36E-05 0.39% 184 10419790 Jub 0.4 1.3 6.8 3.38E-05 0.39% 185 10377439 Per1 -0.9 0.5 8.0 3.39E-05 0.39% 186 10489484 Sdc4 -0.5 0.7 11.5 3.39E-05 0.39% 187 10412038 Zswim6 0.5 1.4 8.1 3.41E-05 0.39% 188 10372410 Glipr1 0.6 1.5 6.1 3.47E-05 0.40% 189 10571984 Ddx60 0.7 1.6 6.8 3.49E-05 0.40% 190 10340072 0.9 1.8 6.5 3.51E-05 0.40% 191 10404595 Ppp1r3g -1.2 0.4 7.3 3.52E-05 0.40% 192 10527475 Zfp655 0.5 1.4 9.1 3.53E-05 0.40% 193 10419854 Slc7a8 0.6 1.5 7.2 3.56E-05 0.40% 194 10452980 Eif2ak2 0.5 1.4 7.5 3.61E-05 0.40%

Page 5 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

195 10371321 Slc41a2 2.4 5.2 10.7 3.63E-05 0.40% 196 10574641 D230025D16Rik -0.5 0.7 10.4 3.71E-05 0.40% 197 10498371 P2ry12 0.5 1.4 6.4 3.75E-05 0.40% 198 10444932 2310014H01Rik 0.4 1.3 6.9 3.75E-05 0.40% 199 10494407 Hist2h2bb 0.7 1.6 6.6 3.77E-05 0.40% 200 10470381 5930434B04Rik 0.4 1.3 8.9 3.77E-05 0.40% 201 10445323 -0.7 0.6 3.5 3.78E-05 0.40% 202 10433633 Mkl2 -0.5 0.7 8.8 3.82E-05 0.41% 203 10554034 Lass3 -1.1 0.5 5.8 3.83E-05 0.41% 204 10457644 Cdh2 -0.4 0.8 10.3 3.87E-05 0.41% 205 10397645 Gpr65 0.6 1.6 6.6 3.92E-05 0.41% 206 10355844 Dnpep 0.5 1.4 8.4 3.94E-05 0.41% 207 10454113 Dsg1a -1.2 0.4 6.0 3.99E-05 0.41% 208 10607868 Tlr8 0.7 1.6 6.5 4.04E-05 0.42% 209 10346607 Fzd7 0.5 1.4 8.3 4.04E-05 0.42% 210 10379034 Tlcd1 -0.6 0.6 10.0 4.07E-05 0.42% 211 10606928 Serpina7 1.6 2.9 7.5 4.10E-05 0.42% 212 10456248 Onecut2 0.6 1.5 10.5 4.19E-05 0.43% 213 10404606 Ly86 1.0 2.0 8.0 4.24E-05 0.43% 214 10358434 Pla2g4a 0.7 1.6 6.5 4.24E-05 0.43% 215 10530145 Tlr1 0.5 1.4 6.0 4.25E-05 0.43% 216 10589413 Nme6 1.0 2.0 9.3 4.30E-05 0.43% 217 10509014 D4Wsu53e -0.5 0.7 10.7 4.35E-05 0.43% 218 10588577 Cish 1.4 2.6 7.9 4.41E-05 0.44% 219 10340709 -0.7 0.6 7.1 4.47E-05 0.44% 220 10468239 Cyp17a1 1.7 3.3 10.8 4.60E-05 0.45% 221 10566050 Il18bp 0.6 1.5 8.4 4.62E-05 0.45% 222 10593225 Zbtb16 -1.7 0.3 8.1 4.66E-05 0.45% 223 10582322 Snai3 1.2 2.3 6.8 4.68E-05 0.45% 224 10525086 Slc24a6 -1.1 0.5 9.3 4.73E-05 0.45% 225 10590635 Ccr5 0.7 1.6 6.2 4.81E-05 0.46% 226 10598013 Ccr5 0.7 1.6 6.2 4.81E-05 0.46% 227 10404218 Gpld1 -0.5 0.7 11.1 4.85E-05 0.46% 228 10542040 Parp11 0.5 1.4 6.7 4.96E-05 0.47% 229 10535898 Gm8615 0.5 1.4 8.0 5.00E-05 0.47% 230 10436662 Mir155 -0.4 0.8 5.5 5.01E-05 0.47% 231 10359908 Rgs4 -0.5 0.7 6.1 5.01E-05 0.47% 232 10351533 Nr1i3 -0.9 0.5 10.8 5.11E-05 0.47% 233 10551209 Cyp2b13 -1.0 0.5 11.0 5.13E-05 0.47% 234 10339974 -0.6 0.6 7.1 5.21E-05 0.48% 235 10340644 -0.7 0.6 9.1 5.24E-05 0.48%

Page 6 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

236 10461622 Ms4a6b 0.7 1.6 6.1 5.33E-05 0.49% 237 10461723 Fam111a 0.8 1.7 6.6 5.41E-05 0.49% 238 10487597 Il1b 1.0 2.0 6.4 5.46E-05 0.49% 239 10344205 -0.5 0.7 9.1 5.53E-05 0.50% 240 10454039 Impact 0.5 1.4 8.6 5.58E-05 0.50% 241 10552276 Ube2h -0.5 0.7 10.0 5.61E-05 0.50% 242 10575993 6430548M08Rik 0.4 1.3 7.2 5.63E-05 0.50% 243 10542880 4833442J19Rik -0.9 0.5 8.8 5.67E-05 0.50% 244 10562576 Plekhf1 -0.8 0.6 7.7 5.74E-05 0.51% 245 10417208 Tmtc4 0.8 1.7 8.1 5.84E-05 0.51% 246 10338993 -0.8 0.6 9.7 5.85E-05 0.51% 247 10584057 Zbtb44 -0.4 0.7 9.6 5.86E-05 0.51% 248 10428912 Fam84b 0.8 1.8 7.8 5.88E-05 0.51% 249 10541389 Gm7298 -1.0 0.5 6.6 5.89E-05 0.51% 250 10369290 Ddit4 -0.9 0.5 7.3 5.89E-05 0.51% 251 10398019 Serpina5 -0.7 0.6 5.4 6.00E-05 0.51% 252 10488617 Nrsn2 -0.3 0.8 6.7 6.00E-05 0.51% 253 10412123 Ncf2 0.4 1.3 7.0 6.02E-05 0.51% 254 10338562 -0.6 0.6 2.7 6.19E-05 0.52% 255 10461636 0.7 1.7 5.2 6.20E-05 0.52% 256 10548552 Klra2 0.6 1.5 4.8 6.27E-05 0.53% 257 10505922 0.7 1.7 7.4 6.30E-05 0.53% 258 10365926 -0.7 0.6 7.9 6.31E-05 0.53% 259 10428439 1.7 3.3 5.7 6.33E-05 0.53% 260 10428918 9930014A18Rik 0.6 1.5 7.4 6.48E-05 0.54% 261 10450484 Aif1 0.6 1.5 6.3 6.50E-05 0.54% 262 10528207 Cd36 1.1 2.2 10.0 6.54E-05 0.54% 263 10469720 Acbd5 -0.5 0.7 10.0 6.64E-05 0.54% 264 10489246 Mafb -1.0 0.5 9.1 6.69E-05 0.55% 265 10535938 N4bp2l1 -0.9 0.5 9.3 6.75E-05 0.55% 266 10420114 Tgm1 1.1 2.1 9.6 6.75E-05 0.55% 267 10465804 Polr2g 0.4 1.3 9.1 6.85E-05 0.55% 268 10346799 Icos 0.6 1.5 6.4 6.86E-05 0.55% 269 10565958 P2ry6 0.4 1.3 6.9 7.01E-05 0.56% 270 10580191 Nfix -0.6 0.7 10.4 7.08E-05 0.56% 271 10547916 Ptms -0.3 0.8 10.7 7.21E-05 0.57% 272 10445953 Emr4 0.7 1.6 7.5 7.46E-05 0.59% 273 10368317 Enpp3 -1.0 0.5 9.0 7.76E-05 0.61% 274 10430372 Rac2 0.5 1.4 7.8 7.80E-05 0.61% 275 10423049 Prlr 1.4 2.7 10.5 7.93E-05 0.62% 276 10603551 Cybb 0.8 1.7 9.1 7.93E-05 0.62%

Page 7 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

277 10352777 Slc30a1 0.4 1.4 9.0 7.93E-05 0.62% 278 10438338 Mir185 -0.5 0.7 7.5 7.98E-05 0.62% 279 10503947 Cga 0.5 1.4 5.8 8.04E-05 0.62% 280 10560672 Cblc -0.4 0.7 7.7 8.05E-05 0.62% 281 10466304 Dtx4 0.6 1.5 7.9 8.13E-05 0.62% 282 10506433 Dab1 -0.3 0.8 6.0 8.18E-05 0.62% 283 10605848 Vsig4 0.7 1.6 10.8 8.33E-05 0.63% 284 10535659 Cyp3a16 0.5 1.4 11.5 8.35E-05 0.63% 285 10405833 -0.5 0.7 5.8 8.38E-05 0.63% 286 10362896 Cd24a 0.8 1.8 6.3 8.44E-05 0.63% 287 10405753 Me1 -0.6 0.7 10.5 8.45E-05 0.63% 288 10511694 Osgin2 0.6 1.6 6.5 8.47E-05 0.63% 289 10522467 Rasl11b 0.5 1.4 7.0 8.61E-05 0.64% 290 10379489 Tmem98 0.6 1.5 7.8 8.74E-05 0.65% 291 10493565 Adar 0.4 1.3 7.4 8.74E-05 0.65% 292 10502335 Bank1 0.7 1.7 7.3 8.78E-05 0.65% 293 10582330 Rnf166 0.4 1.4 8.1 8.79E-05 0.65% 294 10542164 Clec12a 0.9 1.8 7.0 8.99E-05 0.66% 295 10595480 Me1 -0.5 0.7 10.5 9.07E-05 0.66% 296 10505187 Ugcg 0.5 1.5 8.9 9.11E-05 0.66% 297 10590381 Vipr1 -0.4 0.8 7.4 9.12E-05 0.66% 298 10428921 A1bg 0.7 1.7 12.5 9.20E-05 0.66% 299 10545731 Clec4f 0.5 1.4 10.0 9.25E-05 0.67% 300 10534927 Pilra 0.8 1.7 8.1 9.29E-05 0.67% 301 10378068 Xaf1 0.6 1.5 6.7 9.38E-05 0.67% 302 10415415 Khnyn -0.6 0.7 7.2 9.55E-05 0.68% 303 10507347 Tesk2 -0.3 0.8 8.3 9.55E-05 0.68% 304 10453272 Zfp36l2 -0.6 0.7 9.2 9.59E-05 0.68% 305 10527229 2810453I06Rik 0.5 1.4 7.1 9.69E-05 0.68% 306 10376216 Slc36a1 0.6 1.5 9.5 9.71E-05 0.68% 307 10541605 Clec4n 0.7 1.6 6.1 9.71E-05 0.68% 308 10579925 Gab1 -0.3 0.8 8.5 9.95E-05 0.69% 309 10578264 Msr1 0.7 1.6 8.7 1.00E-04 0.69% 310 10363703 Jmjd1c -0.3 0.8 8.8 1.00E-04 0.69% 311 10592126 Fam118b 0.5 1.4 7.3 1.00E-04 0.69% 312 10382271 Arsg 0.5 1.4 7.6 1.02E-04 0.70% 313 10434302 Klhl24 -0.9 0.5 10.1 1.02E-04 0.70% 314 10531544 Paqr3 0.3 1.3 8.2 1.03E-04 0.71% 315 10439249 Parp14 0.4 1.3 8.3 1.04E-04 0.71% 316 10582477 Spata2L -0.8 0.6 7.8 1.05E-04 0.71% 317 10481621 1110008P14Rik 0.5 1.4 7.6 1.05E-04 0.71%

Page 8 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

318 10575750 Bcmo1 0.5 1.4 8.6 1.07E-04 0.72% 319 10339621 -0.7 0.6 7.2 1.07E-04 0.72% 320 10352448 Dusp10 0.5 1.4 7.9 1.07E-04 0.72% 321 10370025 Smarcb1 0.3 1.2 8.2 1.09E-04 0.73% 322 10358879 Npl 0.7 1.6 8.6 1.09E-04 0.73% 323 10425092 Cyth4 0.5 1.4 7.0 1.10E-04 0.73% 324 10340228 -0.7 0.6 6.7 1.11E-04 0.74% 325 10348410 Spp2 0.3 1.3 10.4 1.14E-04 0.75% 326 10474307 0610012H03Rik 0.7 1.6 8.0 1.15E-04 0.75% 327 10584710 H2afx 0.7 1.6 7.4 1.15E-04 0.75% 328 10531420 Cxcl11 1.1 2.1 8.2 1.15E-04 0.75% 329 10498921 Tdo2 -0.8 0.6 12.3 1.16E-04 0.76% 330 10494122 Rfx5 0.5 1.4 7.2 1.17E-04 0.76% 331 10576946 Lig4 0.4 1.3 7.1 1.17E-04 0.76% 332 10428002 -0.4 0.8 7.7 1.17E-04 0.76% 333 10479047 Pck1 -0.7 0.6 12.3 1.17E-04 0.76% 334 10545001 Ppm1k -0.9 0.5 10.0 1.17E-04 0.76% 335 10456745 Smad7 -0.7 0.6 7.4 1.18E-04 0.76% 336 10343552 -0.5 0.7 9.0 1.19E-04 0.76% 337 10533993 Slc15a4 -0.7 0.6 8.8 1.19E-04 0.76% 338 10368606 Gm4794 0.5 1.4 12.3 1.20E-04 0.76% 339 10363070 Gp49a 0.8 1.8 7.3 1.21E-04 0.76% 340 10433639 Mkl2 -0.3 0.8 8.7 1.21E-04 0.77% 341 10406254 Ell2 -0.5 0.7 10.2 1.23E-04 0.77% 342 10449303 Bak1 0.5 1.4 7.9 1.23E-04 0.77% 343 10587748 Adamts7 -0.5 0.7 7.5 1.25E-04 0.78% 344 10379401 Rnf135 0.4 1.3 7.8 1.26E-04 0.78% 345 10524631 Oasl1 0.5 1.4 8.0 1.27E-04 0.78% 346 10552843 Mir150 -0.3 0.8 6.6 1.27E-04 0.78% 347 10586166 0.9 1.9 6.6 1.27E-04 0.78% 348 10543686 Ube2h -0.4 0.7 9.9 1.27E-04 0.78% 349 10405820 -0.7 0.6 6.6 1.28E-04 0.79% 350 10542120 Clec2i 0.4 1.3 6.1 1.28E-04 0.79% 351 10424404 Pvt1 0.8 1.7 6.8 1.29E-04 0.79% 352 10497265 Fabp4 -0.6 0.6 7.1 1.30E-04 0.79% 353 10529979 Ppargc1a -0.6 0.7 8.4 1.31E-04 0.79% 354 10517517 C1qa 0.4 1.4 8.7 1.31E-04 0.79% 355 10537292 1810058I24Rik -0.6 0.7 9.2 1.32E-04 0.79% 356 10358389 Rgs2 0.7 1.7 6.5 1.32E-04 0.79% 357 10446553 Epb4.1l3 0.5 1.4 6.5 1.32E-04 0.79% 358 10419525 A930018M24Rik -0.6 0.7 6.2 1.34E-04 0.81%

Page 9 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

359 10379153 Aldoc -0.4 0.7 8.2 1.37E-04 0.82% 360 10340704 -0.7 0.6 7.8 1.39E-04 0.83% 361 10408266 Hist1h2ba 0.3 1.3 6.4 1.39E-04 0.83% 362 10420891 Scara3 -0.3 0.8 6.3 1.41E-04 0.84% 363 10494735 Gdap2 0.4 1.3 9.9 1.42E-04 0.84% 364 10541587 Clec4a2 0.8 1.7 5.2 1.42E-04 0.84% 365 10524588 Ankrd13a 0.5 1.4 8.6 1.43E-04 0.85% 366 10581813 Mlkl 0.8 1.8 7.4 1.45E-04 0.85% 367 10379727 Gm11428 1.0 2.0 10.5 1.49E-04 0.87% 368 10361787 0.5 1.4 6.1 1.49E-04 0.87% 369 10402368 Serpina6 0.3 1.2 13.6 1.49E-04 0.87% 370 10439268 Dtx3l 0.3 1.3 9.3 1.50E-04 0.87% 371 10498415 Dhx36 0.6 1.6 9.3 1.52E-04 0.88% 372 10396074 Mgat2 0.6 1.5 10.0 1.52E-04 0.88% 373 10568714 Mki67 1.5 2.8 7.3 1.52E-04 0.88% 374 10339052 -0.3 0.8 11.0 1.54E-04 0.88% 375 10497548 Fndc3b 0.7 1.6 9.6 1.54E-04 0.88% 376 10365482 Timp3 -0.5 0.7 8.0 1.54E-04 0.88% 377 10340138 -0.6 0.6 4.5 1.56E-04 0.89% 378 10492091 Smad9 -0.6 0.6 8.0 1.56E-04 0.89% 379 10344421 -0.7 0.6 7.7 1.57E-04 0.89% 380 10582811 Irf2bp2 -0.5 0.7 8.7 1.57E-04 0.89% 381 10392601 Abca6 -0.4 0.8 10.6 1.58E-04 0.89% 382 10396936 Smoc1 0.3 1.2 10.4 1.58E-04 0.89% 383 10566132 Rhog 0.4 1.3 8.4 1.59E-04 0.89% 384 10370931 Mknk2 -0.8 0.6 9.2 1.59E-04 0.89% 385 10546180 Gm839 0.6 1.5 6.2 1.60E-04 0.89% 386 10582809 Tk1 -0.7 0.6 8.8 1.61E-04 0.89% 387 10458731 Mcc -0.6 0.7 9.0 1.61E-04 0.89% 388 10465753 D630002G06Rik -0.9 0.5 6.5 1.62E-04 0.89% 389 10576152 Trappc2l 0.4 1.4 8.7 1.62E-04 0.89% 390 10464772 2010003K11Rik 0.8 1.8 8.1 1.62E-04 0.89% 391 10523359 Cxcl13 1.4 2.6 8.6 1.64E-04 0.90% 392 10512919 Grin3a -0.3 0.8 5.7 1.64E-04 0.90% 393 10513604 Hdhd3 0.9 1.8 9.6 1.64E-04 0.90% 394 10403978 Hist1h2br 0.5 1.4 10.8 1.64E-04 0.90% 395 10403948 Hist1h2be 0.5 1.4 10.7 1.65E-04 0.90% 396 10579347 Ifi30 0.7 1.6 8.7 1.65E-04 0.90% 397 10399924 Pik3cg 0.4 1.3 6.5 1.69E-04 0.91% 398 10505356 Zfp618 -0.3 0.8 6.4 1.69E-04 0.91% 399 10408070 Hist1h2br 0.5 1.4 11.2 1.70E-04 0.91%

Page 10 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

400 10600529 -0.4 0.7 7.7 1.71E-04 0.91% 401 10451953 Lrg1 1.0 2.0 11.3 1.71E-04 0.91% 402 10577096 Pcid2 0.3 1.2 7.8 1.74E-04 0.93% 403 10461154 Snhg1 0.7 1.7 4.1 1.76E-04 0.94% 404 10428983 Fam49b 0.4 1.3 8.0 1.77E-04 0.94% 405 10522788 Stap1 0.9 1.8 7.5 1.78E-04 0.94% 406 10505451 Orm2 1.6 3.0 10.8 1.78E-04 0.94% 407 10607865 Tmsb4x 0.5 1.4 10.5 1.80E-04 0.95% 408 10342517 -0.5 0.7 7.1 1.80E-04 0.95% 409 10429856 Spatc1 0.7 1.7 6.7 1.84E-04 0.97% 410 10375121 -0.5 0.7 6.5 1.86E-04 0.98% 411 10426891 Mettl7a1 -0.5 0.7 11.4 1.86E-04 0.98% 412 10410650 Zfp825 0.4 1.3 9.3 1.88E-04 0.98% 413 10374485 Peli1 -0.4 0.8 8.9 1.89E-04 0.98% 414 10413657 Glt8d1 0.4 1.3 7.6 1.91E-04 0.99% 415 10363894 Ipmk -0.5 0.7 10.0 1.91E-04 0.99% 416 10362201 Ctgf -0.7 0.6 8.2 1.91E-04 0.99% 417 10341193 -0.6 0.6 7.3 1.92E-04 0.99% 418 10341475 -0.8 0.6 6.9 1.93E-04 0.99% 419 10375463 Havcr1 -0.6 0.6 6.4 1.93E-04 0.99% 420 10566254 Hbb-b1 0.8 1.8 12.6 1.93E-04 0.99% 421 10564290 Klf13 -0.6 0.7 8.1 1.94E-04 0.99% 422 10433057 Calcoco1 -0.7 0.6 8.8 1.94E-04 0.99% 423 10586347 Parp16 -0.4 0.8 8.6 1.94E-04 0.99% 424 10456346 Sec11c 0.6 1.5 8.9 1.97E-04 0.99% 425 10461721 Mpeg1 0.7 1.7 9.2 1.97E-04 0.99% 426 10423155 Mtmr12 0.4 1.3 7.9 1.97E-04 0.99% 427 10425987 Ppara -0.5 0.7 11.0 1.98E-04 0.99% 428 10351509 Fcgr4 0.9 1.8 7.0 1.99E-04 0.99% 429 10458314 Tmem173 0.5 1.4 6.8 1.99E-04 0.99% 430 10445241 Tnfrsf21 0.4 1.3 7.9 1.99E-04 0.99% 431 10457686 Dsc2 -0.6 0.7 9.4 2.00E-04 0.99% 432 10540028 Klf15 -0.5 0.7 9.4 2.00E-04 0.99% 433 10478281 -0.4 0.8 5.4 2.00E-04 0.99% 434 10555818 -0.3 0.8 6.2 2.01E-04 0.99% 435 10588836 Gmppb 0.9 1.9 7.2 2.01E-04 0.99% 436 10419288 Gch1 -0.7 0.6 8.6 2.02E-04 0.99% 437 10580033 Cd97 0.4 1.3 8.7 2.02E-04 1.00% 438 10522127 Klb 0.4 1.3 9.9 2.03E-04 1.00% 439 10461150 0.8 1.7 5.5 2.04E-04 1.00% 440 10487823 Siglec1 0.4 1.3 7.5 2.04E-04 1.00%

Page 11 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

441 10420860 Elp3 0.3 1.2 8.5 2.04E-04 1.00% 442 10391207 Dhx58 0.5 1.4 7.3 2.05E-04 1.00% 443 10451580 Bysl 0.5 1.4 7.1 2.05E-04 1.00% 444 10393904 Notum -0.6 0.6 7.5 2.06E-04 1.00% 445 10339211 0.8 1.8 5.8 2.06E-04 1.00% 446 10408210 Hist1h2bc 0.5 1.4 10.8 2.08E-04 1.00% 447 10528527 Fam126a 0.4 1.3 8.1 2.09E-04 1.01% 448 10459193 Ppargc1b -0.6 0.6 7.3 2.10E-04 1.01% 449 10512574 Gba2 -0.6 0.7 7.8 2.12E-04 1.02% 450 10360398 Ifi202b 0.6 1.5 4.6 2.13E-04 1.02% 451 10583519 Icam1 0.4 1.3 7.9 2.13E-04 1.02% 452 10423053 Agxt2 -0.4 0.8 10.2 2.17E-04 1.03% 453 10444788 H2-Q1 -0.6 0.7 8.0 2.19E-04 1.04% 454 10542892 Nacc1 0.3 1.2 8.7 2.21E-04 1.05% 455 10607467 Sat1 0.4 1.3 10.0 2.22E-04 1.05% 456 10504672 Tdrd7 0.3 1.3 8.2 2.25E-04 1.06% 457 10471438 Dpm2 0.5 1.4 8.4 2.25E-04 1.06% 458 10434758 St6gal1 0.5 1.4 9.3 2.26E-04 1.06% 459 10385500 Irgm1 0.6 1.5 9.5 2.30E-04 1.08% 460 10388718 Pipox -0.4 0.8 11.2 2.30E-04 1.08% 461 10360040 Fcgr3 0.5 1.4 7.1 2.31E-04 1.08% 462 10389214 Ccl9 0.3 1.3 11.1 2.33E-04 1.08% 463 10341322 0.7 1.6 6.8 2.37E-04 1.10% 464 10357878 Adora1 -0.7 0.6 7.2 2.38E-04 1.10% 465 10430311 1700061J05Rik -0.3 0.8 5.6 2.39E-04 1.11% 466 10502510 Lmo4 0.5 1.4 7.7 2.40E-04 1.11% 467 10537770 Zyx 0.3 1.2 7.9 2.46E-04 1.13% 468 10393320 Ube2o 0.3 1.2 7.3 2.46E-04 1.13% 469 10385647 Zfp454 0.3 1.3 6.9 2.47E-04 1.13% 470 10501586 S1pr1 0.5 1.4 9.6 2.47E-04 1.13% 471 10340645 0.7 1.6 7.7 2.49E-04 1.13% 472 10566258 0.8 1.8 12.6 2.49E-04 1.13% 473 10443898 Cyp4f15 -0.5 0.7 10.8 2.51E-04 1.14% 474 10534493 Ccl24 0.4 1.3 6.8 2.53E-04 1.15% 475 10585956 Myo9a 0.6 1.5 6.8 2.55E-04 1.15% 476 10546244 Chst13 0.4 1.3 9.1 2.55E-04 1.15% 477 10526087 Sumf2 0.2 1.2 8.5 2.55E-04 1.15% 478 10521892 Slc34a2 1.4 2.6 7.2 2.59E-04 1.17% 479 10520111 Nupl2 0.3 1.3 7.3 2.61E-04 1.17% 480 10433776 Snai2 -0.8 0.6 8.5 2.61E-04 1.17% 481 10338366 0.7 1.6 7.2 2.62E-04 1.17%

Page 12 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

482 10351430 Rxrg 0.5 1.4 8.3 2.62E-04 1.17% 483 10594800 Fam63b -0.6 0.7 8.7 2.65E-04 1.18% 484 10517328 Tmem50a -0.4 0.8 10.9 2.66E-04 1.18% 485 10490682 Zbtb46 -0.3 0.8 6.7 2.66E-04 1.18% 486 10340573 0.4 1.3 11.4 2.69E-04 1.19% 487 10552546 Klk1 0.7 1.6 7.2 2.70E-04 1.19% 488 10353450 Gm4956 -0.5 0.7 4.9 2.72E-04 1.20% 489 10541785 Acrbp -0.4 0.8 6.8 2.74E-04 1.20% 490 10365971 Btg1 -0.5 0.7 10.5 2.77E-04 1.22% 491 10490491 Gata5 -0.4 0.8 6.6 2.78E-04 1.22% 492 10551883 Tyrobp 0.8 1.7 8.6 2.81E-04 1.23% 493 10586168 Snord16a 0.8 1.8 7.8 2.85E-04 1.24% 494 10348932 Gin1 -0.5 0.7 8.4 2.85E-04 1.24% 495 10480672 Ssna1 0.4 1.3 7.1 2.88E-04 1.25% 496 10485183 Slc35c1 0.4 1.3 7.9 2.89E-04 1.25% 497 10430883 Cyp2d13 -0.3 0.8 11.5 2.89E-04 1.25% 498 10477528 4833413D08Rik -0.4 0.7 5.5 2.92E-04 1.26% 499 10582303 Cyba 0.4 1.3 8.2 2.92E-04 1.26% 500 10430931 Nfam1 0.5 1.4 6.5 2.93E-04 1.26% 501 10387648 Tmem102 0.4 1.3 7.9 2.93E-04 1.26% 502 10399421 Mycn -0.4 0.8 6.6 2.95E-04 1.26% 503 10406928 Cd180 0.7 1.6 7.2 2.95E-04 1.26% 504 10466938 5033414D02Rik 0.5 1.4 7.0 2.98E-04 1.27% 505 10529605 Wfs1 0.6 1.5 8.2 2.99E-04 1.27% 506 10458547 Gm8615 0.5 1.4 9.0 3.01E-04 1.28% 507 10445308 Cyp39a1 -1.0 0.5 8.6 3.04E-04 1.29% 508 10474207 Fbxo3 -0.4 0.8 10.7 3.04E-04 1.29% 509 10398601 Rcor1 0.3 1.2 8.9 3.06E-04 1.29% 510 10444459 Tnxb -0.4 0.7 6.9 3.07E-04 1.29% 511 10368713 AI317395 -0.5 0.7 9.4 3.07E-04 1.29% 512 10531100 Sult1d1 -0.7 0.6 11.5 3.08E-04 1.29% 513 10534343 Eln -0.4 0.8 6.7 3.12E-04 1.31% 514 10504072 Dnaic1 -0.4 0.7 6.4 3.14E-04 1.31% 515 10385159 Rars 0.4 1.3 10.1 3.14E-04 1.31% 516 10532616 Myo18b -0.5 0.7 5.9 3.14E-04 1.31% 517 10358224 Ptprc 0.6 1.5 7.8 3.14E-04 1.31% 518 10556583 Nucb2 1.1 2.2 7.3 3.20E-04 1.33% 519 10467871 Dnmbp -0.6 0.7 8.2 3.22E-04 1.33% 520 10568332 Prss8 -0.6 0.7 6.5 3.27E-04 1.35% 521 10604393 Elf4 0.4 1.3 6.3 3.29E-04 1.35% 522 10372648 Lyz2 0.5 1.4 9.8 3.29E-04 1.35%

Page 13 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

523 10518781 Per3 -0.5 0.7 8.7 3.31E-04 1.36% 524 10470628 Ddx31 0.4 1.3 6.9 3.32E-04 1.36% 525 10340096 -0.7 0.6 9.3 3.33E-04 1.36% 526 10432243 Fkbp11 0.6 1.5 6.8 3.33E-04 1.36% 527 10449061 Rhbdl1 -0.2 0.8 6.9 3.33E-04 1.36% 528 10403112 Dnahc11 1.0 2.0 7.6 3.39E-04 1.38% 529 10592585 Sc5d -0.4 0.8 12.0 3.40E-04 1.38% 530 10379936 Tbx2 -0.3 0.8 7.2 3.41E-04 1.39% 531 10512470 Cd72 0.4 1.4 5.3 3.43E-04 1.39% 532 10343623 0.4 1.3 8.5 3.43E-04 1.39% 533 10360070 Fcer1g 0.8 1.7 7.9 3.44E-04 1.39% 534 10606694 Btk 0.5 1.4 5.7 3.47E-04 1.40% 535 10495625 Dpyd -0.3 0.8 11.6 3.48E-04 1.40% 536 10590427 Ccbp2 -0.3 0.8 6.7 3.50E-04 1.40% 537 10440393 Samsn1 0.4 1.3 5.6 3.52E-04 1.40% 538 10356020 Dock10 0.5 1.4 7.3 3.52E-04 1.40% 539 10477649 Acss2 -0.6 0.6 9.9 3.52E-04 1.40% 540 10583485 A230050P20Rik 0.4 1.3 8.9 3.52E-04 1.40% 541 10521863 Anapc4 0.4 1.3 8.5 3.53E-04 1.40% 542 10531737 Hpse 0.4 1.3 7.4 3.54E-04 1.40% 543 10494395 Hist2h2aa1 0.4 1.3 10.6 3.64E-04 1.44% 544 10508663 Laptm5 0.6 1.5 8.6 3.64E-04 1.44% 545 10506388 Tctex1d1 -0.4 0.8 4.5 3.65E-04 1.44% 546 10361790 Fuca2 0.3 1.3 7.5 3.67E-04 1.45% 547 10509163 Id3 1.1 2.2 8.3 3.71E-04 1.46% 548 10520379 Rbm33 -0.4 0.8 8.7 3.75E-04 1.47% 549 10531952 Abcg3 0.5 1.4 6.3 3.78E-04 1.48% 550 10594289 Glce 0.3 1.2 8.8 3.78E-04 1.48% 551 10403980 Hist1h2br 0.5 1.4 11.2 3.79E-04 1.48% 552 10413615 Itih4 0.3 1.2 13.2 3.80E-04 1.48% 553 10444244 Tap1 0.4 1.3 7.6 3.84E-04 1.50% 554 10488415 Cst3 0.2 1.1 12.5 3.85E-04 1.50% 555 10585986 Myo9a 0.5 1.4 7.0 3.86E-04 1.50% 556 10392328 Nol11 0.5 1.4 8.2 3.88E-04 1.50% 557 10349316 Tmem185b 0.3 1.2 7.6 3.89E-04 1.50% 558 10577973 Adrb3 -0.4 0.8 5.3 3.97E-04 1.53% 559 10594802 Fam63b -0.6 0.7 6.7 4.00E-04 1.54% 560 10449280 0.7 1.6 6.0 4.01E-04 1.54% 561 10343922 -0.6 0.7 6.9 4.03E-04 1.54% 562 10341767 0.8 1.8 7.7 4.06E-04 1.55% 563 10544133 Parp12 0.3 1.2 10.0 4.06E-04 1.55%

Page 14 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

564 10421269 Sorbs3 -0.6 0.7 7.6 4.06E-04 1.55% 565 10565858 Gm5115 -0.4 0.8 6.4 4.07E-04 1.55% 566 10342464 0.8 1.8 4.3 4.08E-04 1.55% 567 10438262 Slc25a1 -0.2 0.9 11.1 4.13E-04 1.56% 568 10467979 Scd1 -0.6 0.7 12.3 4.14E-04 1.56% 569 10523901 0.5 1.4 5.9 4.14E-04 1.56% 570 10341047 -1.2 0.4 4.1 4.15E-04 1.56% 571 10405633 Ntrk2 -0.6 0.6 5.9 4.15E-04 1.56% 572 10366814 Cdk4 0.3 1.2 10.9 4.17E-04 1.57% 573 10360328 Apcs 1.0 1.9 11.4 4.19E-04 1.57% 574 10419240 Ddhd1 0.7 1.6 8.9 4.21E-04 1.58% 575 10480035 Pfkfb3 -0.5 0.7 6.7 4.23E-04 1.58% 576 10532944 Mlec 0.5 1.4 10.0 4.24E-04 1.58% 577 10587082 Onecut1 1.5 2.8 10.1 4.25E-04 1.58% 578 10492231 Med12l 0.4 1.3 7.6 4.25E-04 1.58% 579 10390258 Snx11 0.3 1.2 7.1 4.27E-04 1.59% 580 10524345 Tpst2 -0.4 0.7 8.3 4.28E-04 1.59% 581 10493995 S100a10 0.3 1.3 12.6 4.31E-04 1.59% 582 10403943 Hist1h2bm 0.5 1.5 8.6 4.33E-04 1.60% 583 10343599 -0.5 0.7 9.6 4.34E-04 1.60% 584 10462343 -0.4 0.8 6.9 4.35E-04 1.60% 585 10523451 Anxa3 0.5 1.4 6.9 4.36E-04 1.60% 586 10493245 Mex3a -0.4 0.8 5.6 4.39E-04 1.61% 587 10353524 Ogfrl1 -0.4 0.8 7.4 4.42E-04 1.61% 588 10514939 Podn -0.5 0.7 7.4 4.42E-04 1.61% 589 10526133 Rabgef1 -0.3 0.8 8.0 4.42E-04 1.61% 590 10343601 0.8 1.8 7.3 4.44E-04 1.62% 591 10408162 Zfp322a 0.4 1.3 7.1 4.45E-04 1.62% 592 10369102 -0.6 0.7 8.9 4.47E-04 1.62% 593 10547657 C3ar1 0.5 1.5 7.7 4.47E-04 1.62% 594 10533026 Prkab1 0.4 1.3 9.4 4.48E-04 1.62% 595 10511429 Car8 -0.4 0.7 10.6 4.48E-04 1.62% 596 10554704 Mesdc2 0.3 1.2 9.5 4.50E-04 1.62% 597 10347639 Gmppa 0.6 1.5 9.1 4.50E-04 1.62% 598 10568521 2310057M21Rik 0.4 1.3 7.5 4.55E-04 1.63% 599 10521543 Stx18 0.9 1.8 8.8 4.55E-04 1.63% 600 10371420 Prdm4 0.3 1.2 7.6 4.56E-04 1.63% 601 10379630 Slfn2 0.6 1.5 7.2 4.59E-04 1.64% 602 10422760 Fyb 0.6 1.6 7.5 4.60E-04 1.64% 603 10453436 Mcfd2 0.3 1.2 10.1 4.62E-04 1.65% 604 10567022 Btbd10 0.6 1.5 6.7 4.62E-04 1.65%

Page 15 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

605 10568298 Stx1b -0.4 0.8 6.9 4.64E-04 1.65% 606 10407370 4833420G17Rik -0.3 0.8 8.8 4.65E-04 1.65% 607 10573939 Lpcat2 0.4 1.4 7.1 4.69E-04 1.66% 608 10391339 Psmc3ip 0.4 1.3 7.4 4.70E-04 1.66% 609 10480628 Tubb2c 0.6 1.5 9.0 4.70E-04 1.66% 610 10387743 Slc2a4 -0.6 0.7 6.6 4.73E-04 1.67% 611 10397172 Acot6 0.3 1.3 6.9 4.75E-04 1.67% 612 10460833 Ehd1 0.3 1.2 8.7 4.75E-04 1.67% 613 10487476 1500011K16Rik 0.2 1.2 6.9 4.75E-04 1.67% 614 10469312 Pter 0.4 1.3 10.4 4.75E-04 1.67% 615 10592023 Aplp2 -0.2 0.9 11.4 4.78E-04 1.67% 616 10517727 Klhdc7a 0.6 1.5 6.9 4.83E-04 1.69% 617 10571444 Slc7a2 -0.9 0.5 11.0 4.85E-04 1.69% 618 10558285 Zranb1 -0.4 0.8 9.7 4.88E-04 1.70% 619 10533529 Camkk2 0.7 1.6 8.0 4.90E-04 1.70% 620 10381408 Ifi35 0.3 1.3 8.2 4.92E-04 1.71% 621 10578763 Sap30 0.4 1.3 6.5 4.97E-04 1.72% 622 10463282 Entpd7 0.6 1.5 8.0 4.98E-04 1.72% 623 10339748 -0.7 0.6 8.6 4.99E-04 1.72% 624 10410099 Cdc14b -0.7 0.6 8.6 5.03E-04 1.73% 625 10545298 Rmnd5a -0.3 0.8 10.3 5.04E-04 1.73% 626 10540911 Tsen2 0.4 1.3 6.2 5.04E-04 1.73% 627 10487011 Gatm 0.6 1.5 9.9 5.06E-04 1.74% 628 10338834 0.8 1.7 3.6 5.09E-04 1.74% 629 10585778 Sema7a -0.4 0.8 5.3 5.09E-04 1.74% 630 10587077 Onecut1 1.1 2.2 8.8 5.10E-04 1.74% 631 10369531 Tspan15 0.4 1.3 6.9 5.14E-04 1.75% 632 10426889 Sec61b 0.4 1.3 7.1 5.16E-04 1.75% 633 10585972 Myo9a 0.6 1.5 6.7 5.16E-04 1.75% 634 10338455 1.1 2.1 4.8 5.17E-04 1.75% 635 10447130 Pkdcc 0.3 1.3 7.6 5.20E-04 1.76% 636 10420503 Setdb2 -0.7 0.6 8.0 5.21E-04 1.76% 637 10426894 Gm10035 -0.4 0.7 9.9 5.24E-04 1.77% 638 10352548 Slc30a10 0.6 1.5 8.5 5.26E-04 1.77% 639 10582074 Mphosph6 0.8 1.8 7.4 5.26E-04 1.77% 640 10408600 Serpinb6a 0.4 1.3 7.6 5.28E-04 1.77% 641 10419744 Oxa1l 0.6 1.6 7.5 5.28E-04 1.77% 642 10409369 Sncb -0.3 0.8 6.7 5.28E-04 1.77% 643 10606948 Morc4 0.4 1.3 7.2 5.30E-04 1.77% 644 10391301 Stat3 0.4 1.3 10.4 5.31E-04 1.77% 645 10375083 Stk10 0.3 1.2 7.1 5.33E-04 1.77%

Page 16 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

646 10477325 Dnmt3b 0.4 1.3 6.5 5.33E-04 1.77% 647 10398299 Slc25a47 -0.8 0.6 11.0 5.34E-04 1.77% 648 10477604 Itch -0.4 0.8 10.1 5.34E-04 1.77% 649 10395259 Nampt -0.7 0.6 10.5 5.34E-04 1.77% 650 10500570 Hao2 0.7 1.7 10.6 5.35E-04 1.77% 651 10454015 Ttc39c -0.7 0.6 10.1 5.35E-04 1.77% 652 10389606 Prr11 0.8 1.7 6.1 5.36E-04 1.77% 653 10501244 Ampd2 0.3 1.2 8.4 5.36E-04 1.77% 654 10354649 Pgap1 0.4 1.3 10.1 5.45E-04 1.79% 655 10602739 Acot9 0.4 1.3 7.0 5.45E-04 1.79% 656 10592802 C2cd2l 0.5 1.4 8.6 5.46E-04 1.79% 657 10597098 Camp -0.3 0.8 6.3 5.47E-04 1.79% 658 10471721 Ptgs1 0.5 1.4 7.8 5.49E-04 1.79% 659 10585338 Kdelc2 0.3 1.2 7.1 5.50E-04 1.79% 660 10527494 Cyp3a25 -0.5 0.7 11.6 5.50E-04 1.79% 661 10444258 Psmb8 0.4 1.3 7.6 5.52E-04 1.80% 662 10595981 Mras 0.3 1.2 7.1 5.53E-04 1.80% 663 10397332 Eif2b2 0.3 1.2 7.7 5.56E-04 1.80% 664 10567626 Gga2 0.4 1.3 8.2 5.57E-04 1.81% 665 10402136 Gpr68 -0.3 0.8 5.1 5.62E-04 1.82% 666 10561212 Ltbp4 -0.3 0.8 7.7 5.63E-04 1.82% 667 10342723 0.4 1.3 10.6 5.67E-04 1.82% 668 10562130 Ffar1 -0.3 0.8 5.1 5.67E-04 1.82% 669 10512067 Ddx58 0.3 1.2 9.2 5.67E-04 1.82% 670 10499108 Glt28d2 -0.6 0.7 6.2 5.70E-04 1.83% 671 10359161 Soat1 0.4 1.4 7.7 5.70E-04 1.83% 672 10429446 -0.4 0.8 6.8 5.71E-04 1.83% 673 10338326 -0.6 0.6 7.0 5.74E-04 1.83% 674 10420516 Cdadc1 -0.3 0.8 9.3 5.76E-04 1.84% 675 10549012 Gm6614 -0.5 0.7 8.4 5.78E-04 1.84% 676 10430851 Cyp2d22 -0.3 0.8 12.4 5.81E-04 1.85% 677 10553274 Saa2 2.6 6.0 9.2 5.81E-04 1.85% 678 10519488 Tubb2c 0.6 1.5 9.2 5.83E-04 1.85% 679 10515220 Faah -0.3 0.8 9.9 5.84E-04 1.85% 680 10545742 Cd207 0.5 1.4 6.8 5.86E-04 1.85% 681 10400304 Egln3 0.7 1.6 8.1 5.91E-04 1.86% 682 10606016 Il2rg 0.7 1.7 6.7 5.91E-04 1.86% 683 10447023 Heatr5b 0.5 1.5 5.9 5.97E-04 1.88% 684 10542200 Gabarapl1 -0.6 0.7 11.5 5.98E-04 1.88% 685 10581507 Cog8 0.3 1.2 8.4 6.08E-04 1.91% 686 10559261 Cd81 0.2 1.1 12.6 6.14E-04 1.92%

Page 17 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

687 10403743 Inhba 1.1 2.2 8.4 6.16E-04 1.92% 688 10443027 A930001N09Rik -0.7 0.6 8.1 6.16E-04 1.92% 689 10430974 Arfgap3 0.5 1.5 7.6 6.18E-04 1.93% 690 10341840 0.8 1.7 4.5 6.18E-04 1.93% 691 10535698 Cyp3a44 0.4 1.3 11.9 6.23E-04 1.94% 692 10539592 Smyd5 0.4 1.3 7.7 6.26E-04 1.95% 693 10342274 0.7 1.6 6.0 6.28E-04 1.95% 694 10499703 -0.4 0.8 7.5 6.29E-04 1.95% 695 10393166 St6galnac2 0.6 1.5 7.8 6.35E-04 1.97% 696 10398459 Ppp2r5c 0.4 1.3 9.2 6.39E-04 1.97% 697 10607475 Prdx4 0.3 1.2 9.7 6.40E-04 1.97% 698 10531323 G3bp2 0.3 1.3 9.1 6.43E-04 1.98% 699 10537410 Tbxas1 0.4 1.3 6.7 6.44E-04 1.98% 700 10450444 Apom 0.3 1.2 10.4 6.46E-04 1.99% 701 10338905 -0.6 0.6 4.3 6.47E-04 1.99% 702 10591626 Dock6 -0.3 0.8 7.6 6.51E-04 1.99% 703 10385118 Dock2 0.3 1.3 6.7 6.52E-04 2.00% 704 10533131 Plbd2 -0.3 0.8 9.3 6.56E-04 2.00% 705 10573924 Mmp2 -0.5 0.7 7.4 6.56E-04 2.00% 706 10478744 -0.4 0.8 7.2 6.58E-04 2.00% 707 10451993 D17Wsu104e 0.4 1.3 8.3 6.59E-04 2.01% 708 10454514 Lims2 -0.7 0.6 9.5 6.63E-04 2.01% 709 10589846 -0.3 0.8 7.9 6.64E-04 2.01% 710 10350977 4930523C07Rik -0.5 0.7 8.0 6.65E-04 2.01% 711 10420657 Rps12 0.5 1.4 9.2 6.65E-04 2.01% 712 10361139 Traf5 0.4 1.3 7.2 6.67E-04 2.02% 713 10368289 Enpp1 -0.4 0.8 9.8 6.69E-04 2.02% 714 10363082 Lilrb4 0.6 1.5 7.4 6.70E-04 2.02% 715 10380823 Lasp1 0.5 1.5 10.2 6.72E-04 2.02% 716 10417095 Farp1 0.3 1.2 8.0 6.75E-04 2.03% 717 10340879 -0.6 0.6 7.5 6.76E-04 2.03% 718 10601312 Chic1 0.5 1.4 8.9 6.78E-04 2.03% 719 10342580 -1.0 0.5 6.0 6.78E-04 2.03% 720 10462390 Cd274 0.5 1.4 7.0 6.79E-04 2.03% 721 10490159 Pmepa1 -0.3 0.8 7.4 6.81E-04 2.03% 722 10595466 Pgm3 0.5 1.4 8.5 6.82E-04 2.03% 723 10373834 Sec14l4 -0.5 0.7 10.7 6.83E-04 2.03% 724 10541290 Pex26 0.7 1.6 7.3 6.84E-04 2.03% 725 10587880 Pcolce2 0.4 1.3 7.1 6.87E-04 2.04% 726 10600301 Ssr4 0.3 1.2 11.0 6.87E-04 2.04% 727 10492757 Plrg1 0.3 1.3 9.2 7.00E-04 2.07%

Page 18 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

728 10338746 -0.5 0.7 9.4 7.01E-04 2.07% 729 10548785 Dynlt1c 0.5 1.5 9.4 7.05E-04 2.08% 730 10511719 -0.3 0.8 5.7 7.05E-04 2.08% 731 10584024 Opcml -0.3 0.8 5.6 7.10E-04 2.08% 732 10572466 Pde4c -0.5 0.7 7.8 7.10E-04 2.08% 733 10400336 Snx6 0.4 1.3 8.8 7.10E-04 2.08% 734 10347925 Gm7609 0.5 1.4 6.3 7.13E-04 2.09% 735 10443378 Gm749 -0.3 0.8 5.9 7.15E-04 2.09% 736 10513521 Mup20 -0.4 0.8 9.6 7.19E-04 2.10% 737 10381744 Arf2 0.5 1.4 8.1 7.22E-04 2.11% 738 10507933 Inpp5b 0.5 1.4 9.0 7.24E-04 2.11% 739 10490212 Ctsz 0.3 1.2 11.6 7.26E-04 2.11% 740 10473965 Arhgap1 0.3 1.2 8.2 7.30E-04 2.12% 741 10448312 Cldn9 -0.3 0.8 5.8 7.30E-04 2.12% 742 10595803 Rnf7 0.4 1.3 7.9 7.35E-04 2.13% 743 10560742 Vmn1r103 0.4 1.4 3.4 7.38E-04 2.14% 744 10354598 Hecw2 -0.2 0.8 7.1 7.40E-04 2.14% 745 10395925 Mia2 -0.3 0.8 11.2 7.40E-04 2.14% 746 10425321 Apobec3 0.5 1.4 6.3 7.45E-04 2.14% 747 10377790 Slc16a11 -0.4 0.8 7.1 7.45E-04 2.14% 748 10581737 Ddx19b 0.5 1.4 7.8 7.46E-04 2.14% 749 10482509 Rbm43 0.3 1.2 7.0 7.46E-04 2.14% 750 10561104 Axl 0.4 1.3 8.3 7.50E-04 2.15% 751 10463112 Ccnj 0.4 1.4 6.9 7.50E-04 2.15% 752 10350630 Fam129a 0.4 1.3 7.0 7.53E-04 2.15% 753 10456136 Il17b -0.3 0.8 6.7 7.54E-04 2.15% 754 10403959 Hist1h2br 0.4 1.4 10.5 7.54E-04 2.15% 755 10408087 Hist1h2br 0.4 1.4 10.5 7.54E-04 2.15% 756 10387890 Cxcl16 0.3 1.3 7.1 7.55E-04 2.15% 757 10402360 Serpina10 0.6 1.5 11.3 7.59E-04 2.16% 758 10490632 BC006779 0.5 1.4 8.8 7.71E-04 2.19% 759 10338283 0.5 1.4 9.5 7.72E-04 2.19% 760 10454192 Ttr -0.2 0.8 13.4 7.75E-04 2.19% 761 10526842 Zfp157 0.6 1.6 7.5 7.78E-04 2.20% 762 10400866 Trim9 -0.3 0.8 5.3 7.78E-04 2.20% 763 10412260 Fst -0.8 0.6 7.0 7.81E-04 2.20% 764 10406564 Acot12 -0.4 0.8 11.5 7.82E-04 2.20% 765 10357656 0.4 1.3 4.1 7.82E-04 2.20% 766 10544932 Inmt -0.5 0.7 12.6 7.84E-04 2.20% 767 10388392 Dph1 0.3 1.2 8.0 7.88E-04 2.21% 768 10351781 Kcnj10 0.3 1.2 6.9 7.89E-04 2.21%

Page 19 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

769 10597239 Pth1r -0.3 0.8 7.1 7.90E-04 2.21% 770 10369761 Reep3 -0.4 0.8 10.3 7.92E-04 2.21% 771 10356274 Csprs 0.4 1.3 6.2 7.93E-04 2.21% 772 10420497 Gm6907 -0.8 0.6 7.2 8.06E-04 2.24% 773 10598409 Tcfe3 0.3 1.2 8.1 8.16E-04 2.27% 774 10414736 -0.4 0.8 7.4 8.22E-04 2.28% 775 10430265 Eif3d 0.3 1.2 9.5 8.23E-04 2.29% 776 10524621 Oasl2 0.4 1.3 6.9 8.28E-04 2.29% 777 10476383 Crls1 0.4 1.3 8.8 8.28E-04 2.29% 778 10438626 Etv5 0.4 1.3 6.5 8.31E-04 2.30% 779 10431915 Slc38a4 -0.5 0.7 12.0 8.32E-04 2.30% 780 10478407 Serinc3 -0.3 0.8 5.4 8.36E-04 2.30% 781 10360789 Degs1 0.3 1.2 10.9 8.36E-04 2.30% 782 10411780 -0.3 0.8 5.0 8.37E-04 2.30% 783 10447594 Dynlt1a 0.5 1.4 9.4 8.38E-04 2.30% 784 10414360 Lgals3 0.5 1.4 7.3 8.40E-04 2.30% 785 10454105 Dsg1c -0.8 0.6 5.4 8.41E-04 2.30% 786 10586700 Rora -0.4 0.8 9.2 8.43E-04 2.30% 787 10462918 Tmem20 -0.4 0.7 8.9 8.44E-04 2.30% 788 10543239 Tcfec 0.6 1.5 7.8 8.44E-04 2.30% 789 10485070 Mdk -0.3 0.8 6.2 8.47E-04 2.31% 790 10341212 0.8 1.7 3.2 8.49E-04 2.31% 791 10366178 -0.2 0.9 2.6 8.51E-04 2.31% 792 10376245 Gria1 -0.2 0.9 5.4 8.52E-04 2.31% 793 10375145 Lcp2 0.6 1.5 8.0 8.55E-04 2.32% 794 10432640 0.4 1.4 6.4 8.61E-04 2.33% 795 10408118 Hist1h2ao 0.5 1.4 10.3 8.62E-04 2.33% 796 10583669 AB124611 0.4 1.3 7.6 8.66E-04 2.34% 797 10451495 Ubr2 -0.4 0.8 10.1 8.68E-04 2.34% 798 10485963 Arhgap11a 0.9 1.8 5.9 8.68E-04 2.34% 799 10428619 Enpp2 -0.7 0.6 9.7 8.75E-04 2.36% 800 10349904 Golt1a 0.3 1.2 8.2 8.76E-04 2.36% 801 10437483 Rogdi 0.5 1.4 9.1 8.79E-04 2.36% 802 10454966 Ik 0.4 1.3 9.1 8.83E-04 2.37% 803 10425066 Csf2rb 0.6 1.5 7.1 8.91E-04 2.39% 804 10544610 Igf2bp3 -0.3 0.8 5.7 9.03E-04 2.42% 805 10500434 Bcl9 0.4 1.3 7.9 9.08E-04 2.43% 806 10560732 Vmn1r-ps79 0.5 1.4 3.7 9.13E-04 2.44% 807 10342374 -0.4 0.7 6.2 9.15E-04 2.44% 808 10593159 Pafah1b2 0.3 1.3 8.5 9.18E-04 2.44% 809 10544273 Clec5a 0.3 1.3 4.7 9.18E-04 2.44%

Page 20 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

810 10463704 As3mt 0.5 1.5 9.7 9.22E-04 2.45% 811 10395198 0.4 1.3 6.5 9.25E-04 2.45% 812 10494428 Txnip -0.7 0.6 10.0 9.34E-04 2.47% 813 10343172 -0.4 0.8 9.0 9.34E-04 2.47% 814 10340168 -0.4 0.8 9.2 9.35E-04 2.47% 815 10358717 1700025G04Rik -0.3 0.8 8.3 9.42E-04 2.48% 816 10606876 Morf4l2 0.5 1.4 8.7 9.43E-04 2.49% 817 10461558 Slc15a3 0.4 1.3 6.9 9.45E-04 2.49% 818 10585982 Myo9a 0.5 1.4 7.3 9.46E-04 2.49% 819 10411751 Slc30a5 0.4 1.4 9.4 9.48E-04 2.49% 820 10425726 3-Sep -0.3 0.8 5.8 9.52E-04 2.50% 821 10503410 Tmem64 0.9 1.8 10.4 9.58E-04 2.51% 822 10463716 Cnnm2 0.3 1.2 7.9 9.61E-04 2.52% 823 10585992 Myo9a 0.4 1.3 6.5 9.69E-04 2.53% 824 10603627 Bcor 0.4 1.3 7.0 9.72E-04 2.54% 825 10570291 F10 0.2 1.2 11.4 9.77E-04 2.55% 826 10341282 -0.7 0.6 7.9 9.80E-04 2.55% 827 10365426 Psma5 0.3 1.2 8.8 9.83E-04 2.56% 828 10554269 Abhd2 0.3 1.3 11.5 9.85E-04 2.56% 829 10496580 Gbp3 0.6 1.5 7.3 9.89E-04 2.57% 830 10512680 Aurkc -0.2 0.8 6.8 9.93E-04 2.57% 831 10340069 -1.1 0.5 3.1 9.94E-04 2.57% 832 10507798 Mycl1 -0.3 0.8 6.7 9.94E-04 2.57% 833 10576556 -0.3 0.8 8.2 9.94E-04 2.57% 834 10545099 0.4 1.3 7.8 9.97E-04 2.57% 835 10548375 Clec7a 0.6 1.5 6.2 1.00E-03 2.58% 836 10353775 Bend6 0.3 1.2 5.5 1.00E-03 2.58% 837 10390860 Krt23 -0.5 0.7 5.8 1.00E-03 2.58% 838 10587266 Gclc -0.4 0.8 11.7 1.00E-03 2.58% 839 10375472 Timd4 0.5 1.4 8.2 1.01E-03 2.58% 840 10560242 C5ar1 0.5 1.4 6.8 1.01E-03 2.58% 841 10383930 -0.4 0.8 5.6 1.01E-03 2.58% 842 10471844 Nek6 0.4 1.3 9.3 1.01E-03 2.58% 843 10340597 0.5 1.4 7.4 1.01E-03 2.58% 844 10507612 Lepre1 0.4 1.3 7.2 1.01E-03 2.58% 845 10502232 Aimp1 0.3 1.2 7.8 1.02E-03 2.59% 846 10558029 Sec23ip 0.4 1.3 9.4 1.02E-03 2.59% 847 10375123 -0.4 0.8 6.6 1.02E-03 2.60% 848 10344069 0.3 1.2 10.9 1.03E-03 2.61% 849 10340903 -0.5 0.7 7.5 1.03E-03 2.62% 850 10340918 -0.6 0.7 8.2 1.03E-03 2.62%

Page 21 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

851 10421309 Slc39a14 0.5 1.4 10.6 1.04E-03 2.63% 852 10403938 Hist1h2ap 0.5 1.4 10.5 1.04E-03 2.63% 853 10338122 -0.8 0.6 4.5 1.04E-03 2.63% 854 10339067 -0.6 0.6 6.4 1.05E-03 2.64% 855 10341551 -0.6 0.7 10.1 1.05E-03 2.64% 856 10530910 Uba6 0.4 1.3 8.2 1.05E-03 2.64% 857 10489850 Znfx1 0.3 1.2 7.8 1.05E-03 2.64% 858 10570472 Cln8 -0.5 0.7 7.9 1.05E-03 2.64% 859 10572271 Tm6sf2 0.3 1.2 11.4 1.05E-03 2.64% 860 10572235 Lpar2 -0.3 0.8 6.0 1.07E-03 2.67% 861 10408094 Hist1h2ao 0.5 1.4 10.5 1.07E-03 2.67% 862 10374035 Xbp1 0.4 1.3 11.7 1.07E-03 2.67% 863 10608684 Dynll1 0.5 1.4 9.8 1.07E-03 2.68% 864 10499132 Mab21l2 0.3 1.2 6.4 1.08E-03 2.68% 865 10355530 Tns1 -0.4 0.8 8.1 1.08E-03 2.68% 866 10374333 Ikzf1 0.3 1.2 6.2 1.08E-03 2.68% 867 10484503 Lrrc55 -0.4 0.8 5.6 1.08E-03 2.68% 868 10548340 4922502D21Rik -0.3 0.8 5.1 1.08E-03 2.68% 869 10426479 Ano6 0.3 1.2 7.5 1.09E-03 2.68% 870 10551841 Polr2i 0.4 1.3 7.3 1.09E-03 2.68% 871 10439130 Umps 0.3 1.2 8.9 1.09E-03 2.68% 872 10476782 4930529M08Rik -0.4 0.8 4.4 1.09E-03 2.68% 873 10344133 -0.6 0.7 5.5 1.09E-03 2.68% 874 10494565 Fmo5 -0.7 0.6 11.9 1.09E-03 2.68% 875 10534935 Pilrb1 0.5 1.4 7.2 1.09E-03 2.68% 876 10427075 Krt18 0.6 1.6 10.8 1.09E-03 2.68% 877 10555118 Pak1 0.3 1.3 6.0 1.09E-03 2.68% 878 10339414 -1.0 0.5 3.6 1.10E-03 2.69% 879 10343078 0.5 1.5 8.4 1.10E-03 2.69% 880 10344337 0.6 1.6 2.7 1.10E-03 2.70% 881 10518300 Tnfrsf1b -0.3 0.8 8.2 1.11E-03 2.70% 882 10530319 Atp8a1 0.3 1.2 7.5 1.11E-03 2.70% 883 10343529 0.7 1.6 7.7 1.11E-03 2.70% 884 10495306 Mybphl -0.3 0.8 5.6 1.11E-03 2.70% 885 10586448 2810417H13Rik 0.8 1.7 5.6 1.13E-03 2.74% 886 10376060 Irf1 0.6 1.5 8.7 1.13E-03 2.74% 887 10390901 Krtap1-4 -0.3 0.8 5.5 1.13E-03 2.74% 888 10350992 Rc3h1 -0.3 0.8 9.1 1.13E-03 2.74% 889 10487480 Bub1 0.8 1.8 5.6 1.14E-03 2.76% 890 10408085 Hist1h2an 0.5 1.4 10.4 1.15E-03 2.77% 891 10408111 Hist1h2ao 0.5 1.4 10.7 1.15E-03 2.77%

Page 22 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

892 10595664 Tmed3 0.6 1.5 7.2 1.15E-03 2.78% 893 10478973 Cass4 -0.3 0.8 5.2 1.15E-03 2.78% 894 10408072 Hist1h2ao 0.5 1.4 10.8 1.16E-03 2.79% 895 10341543 -0.6 0.6 7.0 1.16E-03 2.79% 896 10492284 C130079G13Rik 0.2 1.2 3.4 1.16E-03 2.79% 897 10569020 Ifitm6 0.4 1.3 5.3 1.16E-03 2.79% 898 10416411 Esd 0.3 1.3 10.8 1.17E-03 2.80% 899 10490016 Sall4 -0.3 0.8 6.0 1.17E-03 2.81% 900 10575052 Cdh1 -0.4 0.8 9.0 1.17E-03 2.81% 901 10338376 0.8 1.7 6.4 1.18E-03 2.81% 902 10543785 AB041803 -0.8 0.6 8.6 1.18E-03 2.81% 903 10593050 Il10ra 0.4 1.3 6.7 1.18E-03 2.81% 904 10548128 Tspan9 0.5 1.4 8.3 1.18E-03 2.81% 905 10489872 Kcnb1 -0.3 0.8 6.4 1.19E-03 2.82% 906 10522604 -0.3 0.8 6.9 1.19E-03 2.82% 907 10416848 -0.3 0.8 5.6 1.19E-03 2.82% 908 10487588 Il1a 0.7 1.6 7.7 1.19E-03 2.82% 909 10584067 Zbtb44 -0.4 0.7 8.2 1.19E-03 2.82% 910 10382802 Sphk1 -0.3 0.8 6.4 1.19E-03 2.82% 911 10491091 Tnfsf10 0.5 1.4 7.8 1.19E-03 2.82% 912 10574976 Pla2g15 0.5 1.4 8.4 1.20E-03 2.82% 913 10513608 Alad 0.4 1.3 12.5 1.20E-03 2.82% 914 10537179 Bpgm 0.5 1.4 7.4 1.20E-03 2.82% 915 10545271 Thnsl2 0.5 1.4 8.5 1.20E-03 2.82% 916 10582997 Casp4 0.4 1.3 6.1 1.20E-03 2.82% 917 10591781 Anln 1.2 2.3 5.8 1.20E-03 2.82% 918 10535477 Usp42 0.3 1.3 8.2 1.21E-03 2.83% 919 10399419 Tubb2b 0.5 1.4 5.7 1.21E-03 2.83% 920 10481759 Slc2a8 -0.2 0.9 7.4 1.21E-03 2.83% 921 10463551 Elovl3 -0.9 0.5 7.1 1.21E-03 2.84% 922 10471457 St6galnac4 0.5 1.4 6.4 1.22E-03 2.84% 923 10524718 Rplp0 0.2 1.2 12.3 1.22E-03 2.84% 924 10433300 -0.6 0.7 5.0 1.22E-03 2.85% 925 10545812 Sfxn5 -0.4 0.8 8.6 1.23E-03 2.85% 926 10347915 Gm7609 0.4 1.3 6.5 1.23E-03 2.85% 927 10556381 Mical2 0.3 1.2 7.4 1.23E-03 2.85% 928 10484201 -0.6 0.7 7.7 1.23E-03 2.85% 929 10600500 2810453I06Rik 0.3 1.3 9.1 1.23E-03 2.85% 930 10391286 Stat5b -0.3 0.8 8.8 1.23E-03 2.85% 931 10529028 Ost4 0.3 1.2 9.0 1.23E-03 2.85% 932 10403955 Hist1h2ao 0.5 1.4 10.7 1.24E-03 2.85%

Page 23 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

933 10338219 -0.6 0.7 6.9 1.24E-03 2.85% 934 10411126 Jmy -0.3 0.8 7.7 1.24E-03 2.85% 935 10349401 Gpr39 0.6 1.5 7.4 1.24E-03 2.85% 936 10375051 Hba-a1 0.8 1.8 12.0 1.24E-03 2.85% 937 10567316 Tmc7 -0.6 0.7 6.1 1.24E-03 2.85% 938 10478897 Ptpn1 0.5 1.4 8.2 1.25E-03 2.85% 939 10575799 Plcg2 0.3 1.2 6.7 1.25E-03 2.85% 940 10358656 Hmcn1 -0.3 0.8 6.3 1.25E-03 2.85% 941 10425834 Samm50 -0.2 0.9 10.2 1.26E-03 2.87% 942 10509542 Ddost 0.3 1.2 10.8 1.26E-03 2.87% 943 10368888 -0.3 0.8 8.6 1.26E-03 2.88% 944 10371796 Slc17a8 -0.6 0.6 7.0 1.27E-03 2.88% 945 10338282 -0.5 0.7 8.5 1.27E-03 2.88% 946 10419934 Myh7 -0.4 0.7 5.6 1.27E-03 2.88% 947 10589909 Trim71 -0.4 0.8 5.9 1.27E-03 2.88% 948 10420362 Gjb2 0.5 1.4 12.1 1.27E-03 2.88% 949 10347291 Cxcr2 0.5 1.4 4.6 1.27E-03 2.88% 950 10397975 Ifi27l1 0.5 1.4 8.6 1.27E-03 2.88% 951 10360377 AI607873 0.6 1.6 6.7 1.28E-03 2.88% 952 10462359 -0.4 0.8 6.0 1.28E-03 2.88% 953 10571036 Ppapdc1b 0.5 1.4 9.7 1.28E-03 2.88% 954 10588243 Ryk -0.3 0.8 9.5 1.28E-03 2.88% 955 10342540 1.0 1.9 5.6 1.28E-03 2.88% 956 10541071 8430408G22Rik -1.5 0.4 9.6 1.28E-03 2.88% 957 10547177 Rassf4 0.4 1.3 6.9 1.28E-03 2.88% 958 10404045 Hist1h2ao 0.5 1.4 10.5 1.28E-03 2.88% 959 10560789 Vmn1r151 0.4 1.3 3.4 1.29E-03 2.89% 960 10343098 -0.4 0.7 8.8 1.29E-03 2.89% 961 10569513 Osbpl5 -0.4 0.8 7.1 1.29E-03 2.89% 962 10446402 Ppp4r1 0.2 1.2 9.6 1.29E-03 2.89% 963 10471550 Rpl12 0.6 1.5 6.7 1.30E-03 2.90% 964 10346533 Nif3l1 0.3 1.3 8.9 1.30E-03 2.90% 965 10403871 Aoah 0.4 1.3 5.7 1.30E-03 2.91% 966 10571728 Rwdd4a 0.3 1.3 9.1 1.31E-03 2.91% 967 10396671 Plekhg3 -0.4 0.8 7.6 1.31E-03 2.91% 968 10347324 Gm216 -0.3 0.8 5.4 1.31E-03 2.92% 969 10445119 H2-M3 0.3 1.2 6.8 1.31E-03 2.92% 970 10488020 Tmx4 -0.3 0.8 9.0 1.32E-03 2.92% 971 10362164 Taar7e -0.3 0.8 3.6 1.32E-03 2.92% 972 10608089 Ube1y1 -0.3 0.8 5.3 1.32E-03 2.92% 973 10523128 Ppbp 0.7 1.6 7.9 1.32E-03 2.93%

Page 24 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

974 10497421 Hps3 0.4 1.3 8.0 1.33E-03 2.93% 975 10513397 1110054O05Rik 0.3 1.2 7.3 1.33E-03 2.94% 976 10563611 Saa1 2.7 6.4 6.9 1.33E-03 2.94% 977 10341464 -0.4 0.7 10.7 1.34E-03 2.95% 978 10378627 Rilp -0.4 0.8 8.3 1.34E-03 2.95% 979 10375058 Hba-a2 0.8 1.8 11.7 1.34E-03 2.95% 980 10368083 Ccdc28a -0.3 0.8 7.5 1.35E-03 2.95% 981 10459210 Arhgef37 -0.5 0.7 6.5 1.35E-03 2.95% 982 10342825 0.7 1.6 6.2 1.35E-03 2.95% 983 10571634 Lrp2bp 0.7 1.6 6.6 1.35E-03 2.95% 984 10538123 Gimap9 0.7 1.7 7.7 1.35E-03 2.95% 985 10453426 Atp6v1e2 -0.2 0.9 6.6 1.35E-03 2.95% 986 10461268 1810009A15Rik 0.3 1.2 6.1 1.35E-03 2.95% 987 10545881 Cml2 0.2 1.2 12.4 1.36E-03 2.97% 988 10370259 Col18a1 -0.3 0.8 9.2 1.36E-03 2.97% 989 10576073 Banp -0.3 0.8 8.0 1.37E-03 2.98% 990 10347593 Speg -0.3 0.8 6.1 1.37E-03 2.98% 991 10575706 Wwox -0.3 0.8 7.6 1.38E-03 3.00% 992 10604656 Xlr 0.9 1.8 4.7 1.39E-03 3.01% 993 10454306 Zfp35 0.4 1.3 7.0 1.39E-03 3.01% 994 10525989 Gpr133 -0.4 0.8 6.3 1.39E-03 3.01% 995 10436865 Ifngr2 0.3 1.2 10.2 1.39E-03 3.01% 996 10514392 Tusc1 -0.2 0.8 7.6 1.39E-03 3.01% 997 10515848 Ermap -0.3 0.8 6.0 1.40E-03 3.02% 998 10361091 Atf3 0.7 1.6 6.9 1.40E-03 3.02% 999 10513957 Ptprd -0.3 0.8 11.0 1.41E-03 3.03% 1000 10605370 Mpp1 0.3 1.3 9.6 1.41E-03 3.03% 1001 10439218 Pdia5 0.3 1.3 10.5 1.41E-03 3.03% 1002 10502791 Ifi44 0.5 1.4 6.5 1.41E-03 3.03% 1003 10414950 Gm5770 -0.3 0.8 3.9 1.41E-03 3.03% 1004 10504831 Sec61b 0.3 1.3 7.7 1.42E-03 3.03% 1005 10438672 Tbccd1 0.3 1.2 9.2 1.42E-03 3.03% 1006 10534909 Sp110 0.4 1.3 6.9 1.42E-03 3.03% 1007 10585467 Agphd1 -0.6 0.7 10.0 1.42E-03 3.03% 1008 10549708 Tmem190 -0.3 0.8 5.9 1.42E-03 3.04% 1009 10340815 0.7 1.6 5.5 1.44E-03 3.07% 1010 10354054 Mitd1 0.5 1.4 7.3 1.44E-03 3.07% 1011 10343934 0.4 1.3 7.9 1.44E-03 3.07% 1012 10361914 -0.3 0.8 4.1 1.45E-03 3.08% 1013 10444658 Clic1 0.4 1.3 8.3 1.45E-03 3.08% 1014 10544186 Mkrn1 0.3 1.2 7.6 1.45E-03 3.08%

Page 25 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1015 10478907 Pard6b 0.3 1.2 7.8 1.46E-03 3.09% 1016 10454172 Dsg2 -0.3 0.8 9.2 1.46E-03 3.09% 1017 10342193 0.7 1.6 8.5 1.47E-03 3.10% 1018 10397818 Cpsf2 0.3 1.2 8.1 1.47E-03 3.10% 1019 10343522 0.5 1.5 2.4 1.47E-03 3.10% 1020 10567355 Gprc5b -0.3 0.8 5.9 1.47E-03 3.11% 1021 10534940 Pilrb2 0.4 1.3 5.9 1.48E-03 3.12% 1022 10383767 Osbp2 -0.3 0.8 6.6 1.49E-03 3.14% 1023 10408610 Tubb2a 1.1 2.2 8.2 1.50E-03 3.15% 1024 10450605 Tubb5 0.6 1.5 10.0 1.50E-03 3.15% 1025 10472860 Rapgef4 -0.3 0.8 10.7 1.50E-03 3.15% 1026 10343661 -0.5 0.7 6.6 1.50E-03 3.15% 1027 10505008 Slc44a1 -0.2 0.9 9.5 1.51E-03 3.16% 1028 10430489 Pla2g6 -0.3 0.8 8.8 1.51E-03 3.16% 1029 10405504 Caml 0.3 1.2 8.3 1.51E-03 3.16% 1030 10490150 Zbp1 0.8 1.7 8.2 1.51E-03 3.16% 1031 10537227 Tmem140 -0.4 0.8 8.3 1.51E-03 3.16% 1032 10341722 -0.7 0.6 6.1 1.52E-03 3.16% 1033 10443946 Actl9 -0.3 0.8 5.7 1.52E-03 3.16% 1034 10365578 Nup37 0.4 1.3 7.8 1.52E-03 3.17% 1035 10422249 Dct 0.4 1.4 6.4 1.53E-03 3.17% 1036 10409567 Tifab 0.4 1.3 6.2 1.53E-03 3.17% 1037 10513869 Megf9 -0.3 0.8 8.8 1.53E-03 3.17% 1038 10339900 1.4 2.6 3.5 1.53E-03 3.17% 1039 10516502 Hmgb4 -0.3 0.8 5.0 1.53E-03 3.17% 1040 10585976 Myo9a 0.7 1.7 6.0 1.54E-03 3.18% 1041 10454651 0.4 1.3 7.4 1.54E-03 3.18% 1042 10567458 -0.4 0.8 6.3 1.54E-03 3.18% 1043 10338507 -0.5 0.7 7.3 1.54E-03 3.18% 1044 10448593 Traf7 0.2 1.2 7.5 1.54E-03 3.18% 1045 10488929 Eif6 0.3 1.2 10.0 1.55E-03 3.18% 1046 10347928 Sp110 0.4 1.3 5.8 1.55E-03 3.18% 1047 10582874 Sp110 0.4 1.3 5.8 1.55E-03 3.18% 1048 10460498 Slc29a2 -0.2 0.9 6.8 1.55E-03 3.18% 1049 10443980 Myo1f 0.4 1.3 6.2 1.55E-03 3.18% 1050 10446713 Snord53 0.7 1.6 7.2 1.55E-03 3.18% 1051 10342182 0.8 1.7 4.5 1.56E-03 3.19% 1052 10425053 Ncf4 0.3 1.2 6.3 1.57E-03 3.20% 1053 10557009 Eef2k 0.2 1.2 7.4 1.57E-03 3.20% 1054 10461071 2700081O15Rik -0.2 0.9 6.9 1.57E-03 3.20% 1055 10542650 Golt1b 0.5 1.5 8.0 1.58E-03 3.21%

Page 26 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1056 10343068 -0.5 0.7 7.3 1.58E-03 3.21% 1057 10535174 Tmem184a 0.6 1.5 8.9 1.58E-03 3.21% 1058 10587818 Plscr4 -0.3 0.8 6.6 1.58E-03 3.21% 1059 10551185 Tgfb1 0.3 1.2 7.6 1.58E-03 3.21% 1060 10433114 Itga5 0.5 1.5 8.3 1.58E-03 3.21% 1061 10415640 Snora65 0.5 1.4 7.0 1.58E-03 3.21% 1062 10435345 Mylk -0.4 0.8 9.1 1.59E-03 3.23% 1063 10364460 Gzmm -0.3 0.8 6.3 1.60E-03 3.23% 1064 10413993 Gm626 -0.4 0.8 4.5 1.60E-03 3.23% 1065 10394611 Nbas 0.4 1.3 7.9 1.60E-03 3.23% 1066 10596545 Rad54l2 -0.3 0.8 8.3 1.60E-03 3.23% 1067 10587284 Elovl5 -0.3 0.8 12.0 1.60E-03 3.23% 1068 10350838 2810417H13Rik 0.4 1.3 7.1 1.60E-03 3.23% 1069 10355582 Usp37 0.4 1.3 7.0 1.61E-03 3.23% 1070 10566144 Trim21 0.3 1.2 7.7 1.61E-03 3.23% 1071 10344007 0.5 1.4 3.1 1.61E-03 3.23% 1072 10343205 0.4 1.3 2.8 1.61E-03 3.23% 1073 10359917 Hsd17b7 -0.4 0.8 9.8 1.61E-03 3.23% 1074 10394068 Sectm1a 0.4 1.3 6.6 1.61E-03 3.23% 1075 10402283 Itpk1 0.4 1.3 8.0 1.62E-03 3.23% 1076 10495035 Slc16a1 0.5 1.4 10.1 1.62E-03 3.23% 1077 10366546 Cpm -0.5 0.7 6.2 1.62E-03 3.23% 1078 10364950 Gadd45b 0.6 1.5 7.6 1.62E-03 3.23% 1079 10548817 Plbd1 0.2 1.2 10.2 1.62E-03 3.24% 1080 10554445 Prc1 1.0 2.1 5.6 1.63E-03 3.24% 1081 10601874 Tceal3 -0.3 0.8 5.2 1.63E-03 3.25% 1082 10492709 Accn5 -0.5 0.7 6.8 1.64E-03 3.25% 1083 10338280 0.7 1.6 8.7 1.64E-03 3.25% 1084 10395273 Gdap10 -0.7 0.6 7.7 1.64E-03 3.26% 1085 10507171 Cyp4a31 0.7 1.6 11.0 1.64E-03 3.26% 1086 10585980 Myo9a 0.4 1.3 6.1 1.65E-03 3.27% 1087 10439411 Nr1i2 -0.4 0.7 9.9 1.65E-03 3.27% 1088 10502748 Lphn2 0.3 1.3 9.5 1.65E-03 3.27% 1089 10413598 Tmem110 0.3 1.2 7.1 1.66E-03 3.27% 1090 10476489 -0.5 0.7 4.5 1.66E-03 3.28% 1091 10494208 Fam63a 0.4 1.3 8.2 1.67E-03 3.28% 1092 10378395 Olfr20 -0.2 0.8 5.8 1.67E-03 3.28% 1093 10494972 Bcl2l15 -0.4 0.8 4.7 1.67E-03 3.28% 1094 10382470 Tmem104 0.4 1.3 8.3 1.67E-03 3.28% 1095 10430899 Cyp2d40 0.6 1.5 8.7 1.67E-03 3.28% 1096 10542302 Crebl2 -0.2 0.9 9.0 1.67E-03 3.28%

Page 27 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1097 10530652 Scfd2 0.4 1.3 7.0 1.67E-03 3.28% 1098 10342442 0.3 1.2 12.1 1.67E-03 3.28% 1099 10414778 Gm16454 -0.3 0.8 4.6 1.68E-03 3.28% 1100 10414885 Gm16454 -0.3 0.8 4.6 1.68E-03 3.28% 1101 10404026 Hist1h2af 0.5 1.4 10.9 1.69E-03 3.30% 1102 10375232 -0.4 0.8 7.1 1.69E-03 3.30% 1103 10501121 Fam40a 0.2 1.2 8.3 1.69E-03 3.30% 1104 10444056 Daxx 0.3 1.2 7.1 1.70E-03 3.30% 1105 10384051 Gck -0.8 0.6 8.9 1.70E-03 3.30% 1106 10595953 Esyt3 -0.3 0.8 6.4 1.70E-03 3.31% 1107 10341688 -0.5 0.7 3.6 1.70E-03 3.31% 1108 10428426 Sybu 0.3 1.2 7.2 1.70E-03 3.31% 1109 10398885 AW555464 0.4 1.3 8.4 1.71E-03 3.31% 1110 10389143 Slfn8 0.4 1.3 5.4 1.71E-03 3.31% 1111 10561712 Spint2 -0.2 0.9 9.0 1.71E-03 3.31% 1112 10515836 Ccnb1 1.2 2.3 6.1 1.71E-03 3.31% 1113 10601601 0.4 1.3 9.1 1.71E-03 3.31% 1114 10430866 Cyp2d10 -0.3 0.8 10.6 1.72E-03 3.32% 1115 10404077 Slc17a2 -0.4 0.7 10.4 1.72E-03 3.33% 1116 10343245 0.4 1.3 8.6 1.73E-03 3.33% 1117 10369909 0.6 1.5 7.1 1.73E-03 3.33% 1118 10581479 Smpd3 -0.3 0.8 6.2 1.74E-03 3.34% 1119 10527448 Bud31 0.3 1.3 9.8 1.74E-03 3.35% 1120 10517443 Tceb3 0.3 1.2 8.6 1.74E-03 3.35% 1121 10420675 Gucy1b2 -0.3 0.8 4.8 1.75E-03 3.35% 1122 10389421 Ints2 0.5 1.4 6.9 1.75E-03 3.36% 1123 10340881 -0.8 0.6 3.4 1.75E-03 3.36% 1124 10554800 Rab38 0.4 1.4 6.0 1.76E-03 3.36% 1125 10500122 Bnipl -0.3 0.8 5.8 1.76E-03 3.36% 1126 10342211 -1.0 0.5 4.8 1.76E-03 3.36% 1127 10496539 Gbp5 0.4 1.3 5.2 1.76E-03 3.36% 1128 10456492 D18Ertd653e -0.5 0.7 7.6 1.76E-03 3.36% 1129 10439392 Gtf2e1 0.4 1.3 7.7 1.76E-03 3.36% 1130 10607557 -0.3 0.8 6.2 1.77E-03 3.36% 1131 10488623 Sox12 -0.2 0.9 6.4 1.77E-03 3.37% 1132 10546624 Lmod3 -0.4 0.8 5.8 1.77E-03 3.37% 1133 10408348 Mrs2 0.3 1.3 7.8 1.78E-03 3.38% 1134 10541112 0.5 1.4 8.2 1.78E-03 3.38% 1135 10360684 Ephx1 -0.5 0.7 11.1 1.79E-03 3.39% 1136 10494402 Hist2h3c1 0.7 1.7 10.3 1.79E-03 3.39% 1137 10526726 Zkscan1 -0.4 0.8 9.6 1.79E-03 3.39%

Page 28 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1138 10527465 Zkscan5 0.3 1.2 7.1 1.80E-03 3.39% 1139 10588638 Tmem115 0.2 1.2 7.4 1.80E-03 3.39% 1140 10405822 Cdk20 -0.2 0.8 6.8 1.80E-03 3.40% 1141 10467319 Rbp4 -0.2 0.9 13.5 1.80E-03 3.40% 1142 10395129 Tmem18 0.3 1.2 9.6 1.81E-03 3.41% 1143 10500327 Hist2h3c2-ps 0.7 1.6 5.5 1.81E-03 3.41% 1144 10469695 Apbb1ip 0.4 1.4 6.6 1.81E-03 3.41% 1145 10587350 0.3 1.2 4.5 1.81E-03 3.41% 1146 10572800 Klf2 -0.3 0.8 7.4 1.82E-03 3.41% 1147 10420747 Gata4 0.2 1.2 8.4 1.83E-03 3.43% 1148 10461594 Ms4a4c 0.6 1.5 5.2 1.83E-03 3.43% 1149 10420591 0.3 1.2 7.6 1.83E-03 3.43% 1150 10534990 Taf6 0.3 1.2 9.4 1.84E-03 3.44% 1151 10370632 Rnf126 0.3 1.3 9.4 1.84E-03 3.44% 1152 10360479 Cep170 0.3 1.3 7.0 1.85E-03 3.45% 1153 10427148 Zfp740 -0.3 0.8 7.0 1.85E-03 3.45% 1154 10418247 Pde12 0.4 1.3 7.1 1.85E-03 3.45% 1155 10338693 -1.1 0.5 5.9 1.85E-03 3.45% 1156 10500982 I830077J02Rik 0.3 1.2 6.0 1.86E-03 3.45% 1157 10398350 Mir341 -0.3 0.8 7.2 1.86E-03 3.45% 1158 10419034 2610528A11Rik -0.3 0.8 6.9 1.86E-03 3.45% 1159 10449289 -0.3 0.8 5.3 1.86E-03 3.45% 1160 10590343 Trak1 -0.2 0.9 9.1 1.87E-03 3.46% 1161 10435031 Ubxn7 -0.3 0.8 8.6 1.87E-03 3.46% 1162 10386909 Cenpv 0.2 1.2 9.3 1.88E-03 3.48% 1163 10582310 Mvd 0.7 1.6 8.4 1.88E-03 3.48% 1164 10438098 Sdf2l1 0.9 1.9 10.1 1.88E-03 3.48% 1165 10553475 Rps27a 0.3 1.2 8.5 1.89E-03 3.49% 1166 10577645 Ido2 -0.5 0.7 10.3 1.90E-03 3.51% 1167 10541049 8-Mar -0.3 0.8 9.6 1.91E-03 3.51% 1168 10435769 Zbtb20 -0.4 0.8 10.1 1.91E-03 3.52% 1169 10587653 Snx14 -0.3 0.8 7.4 1.91E-03 3.52% 1170 10533401 0.7 1.6 8.6 1.91E-03 3.52% 1171 10512274 Enho -0.5 0.7 7.4 1.92E-03 3.53% 1172 10488237 Snx5 0.3 1.2 9.7 1.92E-03 3.53% 1173 10545065 Gprin3 -0.5 0.7 8.4 1.93E-03 3.54% 1174 10381272 Cntnap1 0.3 1.2 6.1 1.93E-03 3.54% 1175 10512279 Cntfr -0.3 0.8 7.2 1.94E-03 3.54% 1176 10488264 Calcoco2 -0.3 0.8 4.7 1.94E-03 3.55% 1177 10596137 Srprb 0.5 1.4 9.4 1.94E-03 3.55% 1178 10344235 0.4 1.3 9.2 1.95E-03 3.55%

Page 29 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1179 10535683 Cyp3a41a 0.2 1.1 13.1 1.95E-03 3.55% 1180 10508368 A3galt2 -0.3 0.8 5.5 1.95E-03 3.55% 1181 10481474 Crat 0.5 1.4 9.4 1.96E-03 3.56% 1182 10338521 -0.4 0.7 7.1 1.96E-03 3.57% 1183 10416256 Bin3 0.2 1.2 8.6 1.97E-03 3.57% 1184 10576118 9330133O14Rik 0.3 1.2 6.2 1.97E-03 3.57% 1185 10425852 Parvb 0.2 1.2 6.6 1.97E-03 3.57% 1186 10480699 Dpp7 -0.3 0.8 8.7 1.98E-03 3.58% 1187 10349724 Rab7l1 0.3 1.2 8.3 1.98E-03 3.58% 1188 10409592 Lect2 -0.3 0.8 12.1 1.98E-03 3.58% 1189 10500580 -0.3 0.8 5.6 1.98E-03 3.58% 1190 10483768 -0.3 0.8 5.1 1.99E-03 3.59% 1191 10411595 Naip2 0.3 1.2 6.9 1.99E-03 3.59% 1192 10484704 Olfr1157 -0.4 0.8 4.8 1.99E-03 3.59% 1193 10417561 Fam107a -0.3 0.8 6.3 1.99E-03 3.59% 1194 10417734 Nr1d2 -0.4 0.8 10.0 2.00E-03 3.59% 1195 10339562 -0.8 0.6 3.4 2.00E-03 3.59% 1196 10604424 Zfp280c 0.3 1.3 7.7 2.00E-03 3.60% 1197 10404065 Hist2h3b 0.8 1.8 10.6 2.00E-03 3.60% 1198 10339416 -0.6 0.7 5.3 2.02E-03 3.62% 1199 10376455 Hist3h2a 0.2 1.2 7.8 2.02E-03 3.62% 1200 10501795 Rwdd3 -0.5 0.7 7.4 2.02E-03 3.62% 1201 10572357 Cope 0.3 1.2 10.4 2.02E-03 3.62% 1202 10575917 Wfdc1 -0.3 0.8 7.0 2.03E-03 3.62% 1203 10507131 Tal1 -0.3 0.8 6.9 2.03E-03 3.63% 1204 10568109 Asphd1 -0.3 0.8 6.4 2.03E-03 3.63% 1205 10408246 Hist1h3a 0.8 1.7 10.5 2.04E-03 3.63% 1206 10431894 Slc38a2 -0.5 0.7 11.1 2.04E-03 3.63% 1207 10376868 Trpv2 0.2 1.2 6.1 2.04E-03 3.63% 1208 10402585 Wars 0.5 1.4 8.5 2.04E-03 3.63% 1209 10485309 -0.3 0.8 5.1 2.05E-03 3.64% 1210 10585984 Myo9a 0.3 1.2 3.4 2.06E-03 3.66% 1211 10419343 Atg14 -0.5 0.7 8.1 2.07E-03 3.67% 1212 10426451 Irak4 0.3 1.2 8.0 2.07E-03 3.67% 1213 10449914 Zfp871 -0.4 0.8 9.9 2.07E-03 3.67% 1214 10441633 Ccr6 -0.3 0.8 5.7 2.08E-03 3.68% 1215 10346340 9430016H08Rik 0.4 1.3 7.5 2.08E-03 3.68% 1216 10562192 Fxyd5 0.5 1.4 9.2 2.08E-03 3.68% 1217 10546967 Sec13 0.5 1.5 9.3 2.08E-03 3.68% 1218 10343107 -0.4 0.8 12.4 2.09E-03 3.68% 1219 10514054 Nfib -0.3 0.8 11.0 2.09E-03 3.68%

Page 30 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1220 10576835 Cd209f 0.8 1.8 6.8 2.09E-03 3.68% 1221 10457963 Gpr17 -0.3 0.8 6.2 2.09E-03 3.68% 1222 10574163 Nlrc5 0.3 1.2 6.5 2.09E-03 3.69% 1223 10350473 B3galt2 0.2 1.2 4.5 2.10E-03 3.69% 1224 10363762 Tmem26 0.3 1.2 6.6 2.10E-03 3.69% 1225 10511311 Tmem68 0.2 1.2 7.7 2.11E-03 3.70% 1226 10387985 A430084P05Rik 0.6 1.5 6.7 2.11E-03 3.70% 1227 10593947 Cplx3 -0.3 0.8 5.4 2.11E-03 3.70% 1228 10431137 -0.3 0.8 7.2 2.11E-03 3.70% 1229 10569113 Cdhr5 -0.3 0.8 9.2 2.11E-03 3.70% 1230 10348244 Inpp5d 0.3 1.2 7.2 2.12E-03 3.71% 1231 10602033 Cldn2 0.4 1.3 8.8 2.12E-03 3.71% 1232 10434148 0.3 1.2 7.8 2.13E-03 3.71% 1233 10435075 Tfrc 0.9 1.9 8.8 2.13E-03 3.71% 1234 10435443 Hspbap1 0.4 1.3 6.6 2.13E-03 3.71% 1235 10507914 Sf3a3 0.4 1.3 9.2 2.13E-03 3.71% 1236 10542911 Samd9l 0.4 1.3 7.0 2.13E-03 3.71% 1237 10601385 Tlr13 0.6 1.5 7.4 2.14E-03 3.71% 1238 10582879 Csprs 0.4 1.3 6.3 2.14E-03 3.71% 1239 10562637 Ccnb1 1.4 2.7 6.9 2.14E-03 3.71% 1240 10363901 Etv5 0.3 1.3 7.1 2.15E-03 3.72% 1241 10502780 Lphn2 0.3 1.2 11.2 2.15E-03 3.72% 1242 10399897 Hbp1 -0.4 0.8 10.2 2.15E-03 3.73% 1243 10494405 Hist2h3b 0.8 1.7 10.4 2.16E-03 3.73% 1244 10497636 -0.3 0.8 5.6 2.17E-03 3.75% 1245 10351390 Tada1 0.2 1.2 8.7 2.17E-03 3.75% 1246 10572109 Ints10 0.2 1.2 7.8 2.17E-03 3.75% 1247 10413609 Mustn1 0.7 1.6 8.1 2.18E-03 3.75% 1248 10532954 Mlec 0.6 1.5 8.7 2.18E-03 3.75% 1249 10404049 Hist1h3d 0.8 1.8 10.5 2.18E-03 3.75% 1250 10348643 Olfr12 -0.3 0.8 5.4 2.18E-03 3.75% 1251 10541695 Lpcat3 -0.5 0.7 11.1 2.19E-03 3.77% 1252 10571653 Actg1 0.5 1.4 11.4 2.19E-03 3.77% 1253 10341912 0.7 1.6 5.4 2.20E-03 3.78% 1254 10524973 2410131K14Rik -0.3 0.8 7.5 2.21E-03 3.78% 1255 10411668 Ocln -0.5 0.7 8.3 2.21E-03 3.78% 1256 10450226 Ppt2 0.2 1.1 8.8 2.21E-03 3.78% 1257 10385513 9930111J21Rik2 0.4 1.4 7.1 2.22E-03 3.79% 1258 10471154 Ass1 -0.3 0.8 12.8 2.22E-03 3.79% 1259 10596442 Ppm1m -0.2 0.9 7.8 2.22E-03 3.79% 1260 10476012 Gm14047 -0.3 0.8 4.9 2.23E-03 3.81%

Page 31 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1261 10377405 Aurkb 0.9 1.8 7.1 2.23E-03 3.81% 1262 10521589 Cir1 -0.4 0.8 6.8 2.24E-03 3.81% 1263 10383012 Pgs1 0.4 1.3 8.2 2.24E-03 3.82% 1264 10435565 Hcls1 0.3 1.2 7.6 2.24E-03 3.82% 1265 10379779 Ddx52 0.3 1.2 8.0 2.25E-03 3.82% 1266 10457508 Npc1 -0.5 0.7 11.1 2.25E-03 3.83% 1267 10515983 Dem1 0.2 1.2 6.6 2.26E-03 3.83% 1268 10390186 Abi3 0.3 1.3 7.6 2.26E-03 3.83% 1269 10475941 Zc3h6 -0.5 0.7 6.5 2.26E-03 3.83% 1270 10340243 1.1 2.1 3.8 2.26E-03 3.83% 1271 10363512 Sar1a 0.2 1.2 10.6 2.26E-03 3.83% 1272 10561516 Nfkbib 0.3 1.2 9.5 2.27E-03 3.83% 1273 10522668 Paics -0.3 0.8 11.6 2.27E-03 3.83% 1274 10338558 0.4 1.3 10.8 2.27E-03 3.84% 1275 10531887 Slc10a6 -0.3 0.8 5.4 2.28E-03 3.84% 1276 10461022 Ppp1r14b 0.5 1.4 8.5 2.28E-03 3.84% 1277 10396919 4933426M11Rik -0.4 0.8 9.5 2.28E-03 3.84% 1278 10342008 0.7 1.7 4.2 2.28E-03 3.84% 1279 10450367 Hspa1a -0.7 0.6 8.8 2.29E-03 3.84% 1280 10506786 Zcchc11 -0.3 0.8 9.4 2.29E-03 3.84% 1281 10461934 Trpm6 -0.3 0.8 5.3 2.29E-03 3.85% 1282 10403273 Asb13 0.3 1.2 10.2 2.30E-03 3.85% 1283 10381238 Mlx 0.3 1.2 10.5 2.30E-03 3.85% 1284 10353181 Lactb2 -0.3 0.8 11.2 2.30E-03 3.86% 1285 10594774 Ccnb2 1.2 2.3 7.7 2.31E-03 3.86% 1286 10445325 Rcan2 0.8 1.8 8.5 2.31E-03 3.86% 1287 10421197 Chmp7 0.2 1.2 8.1 2.31E-03 3.86% 1288 10404028 Hist1h3g 0.8 1.7 10.5 2.31E-03 3.86% 1289 10490736 Rgs19 0.3 1.2 7.2 2.31E-03 3.86% 1290 10597920 Zdhhc3 0.2 1.1 8.8 2.31E-03 3.86% 1291 10529549 Tbc1d14 0.3 1.3 7.4 2.32E-03 3.86% 1292 10441313 C2cd2 -0.3 0.8 9.9 2.32E-03 3.86% 1293 10566400 Olfr667 -0.2 0.9 5.0 2.32E-03 3.86% 1294 10384448 Sec61g 0.4 1.3 10.0 2.33E-03 3.86% 1295 10434396 Abcf3 0.3 1.2 8.9 2.33E-03 3.86% 1296 10504743 Nans 0.5 1.4 7.7 2.33E-03 3.86% 1297 10603440 Was 0.3 1.2 6.5 2.33E-03 3.86% 1298 10343037 0.4 1.3 7.8 2.33E-03 3.86% 1299 10338657 -0.6 0.7 8.1 2.33E-03 3.86% 1300 10571975 -0.3 0.8 7.5 2.34E-03 3.86% 1301 10607806 Ofd1 0.3 1.2 6.8 2.34E-03 3.86%

Page 32 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1302 10488404 Cst11 -0.3 0.8 6.4 2.34E-03 3.86% 1303 10593384 Dixdc1 -0.4 0.8 7.4 2.34E-03 3.86% 1304 10408202 Hist1h3f 0.8 1.7 10.4 2.34E-03 3.86% 1305 10580649 Ces1e -0.4 0.8 10.8 2.34E-03 3.86% 1306 10408239 Hist1h3f 0.8 1.8 10.6 2.34E-03 3.86% 1307 10430006 Slc39a4 -0.3 0.8 8.9 2.34E-03 3.86% 1308 10467153 Slc16a12 -0.5 0.7 10.5 2.35E-03 3.86% 1309 10346882 Adam23 0.4 1.3 8.4 2.35E-03 3.86% 1310 10411739 Ccnb1 1.3 2.5 6.5 2.35E-03 3.86% 1311 10351045 0.6 1.5 3.8 2.36E-03 3.86% 1312 10349947 Fmod -0.7 0.6 6.4 2.37E-03 3.88% 1313 10581664 Il34 -0.3 0.8 6.4 2.37E-03 3.88% 1314 10389231 Ccl3 0.5 1.4 6.1 2.37E-03 3.88% 1315 10576274 Zfp276 -0.4 0.8 7.1 2.37E-03 3.88% 1316 10341164 -0.4 0.8 9.2 2.38E-03 3.88% 1317 10565018 Iqgap1 0.3 1.2 7.4 2.38E-03 3.89% 1318 10556581 0.8 1.7 7.8 2.39E-03 3.90% 1319 10559547 Tnnt1 -0.4 0.8 5.7 2.39E-03 3.90% 1320 10406067 Clptm1l 0.3 1.2 10.2 2.39E-03 3.90% 1321 10428328 Slc25a32 -0.5 0.7 8.9 2.40E-03 3.90% 1322 10437174 Wrb 0.4 1.3 8.0 2.40E-03 3.90% 1323 10389786 Hlf -0.3 0.8 8.7 2.41E-03 3.90% 1324 10600777 AU015836 -0.2 0.8 5.1 2.41E-03 3.90% 1325 10559238 Igf2as -0.3 0.8 7.7 2.41E-03 3.90% 1326 10403941 Hist1h3g 0.8 1.7 10.5 2.41E-03 3.90% 1327 10559181 Krtap5-4 -0.3 0.8 6.4 2.41E-03 3.90% 1328 10459518 Mppe1 0.2 1.2 7.4 2.42E-03 3.90% 1329 10594590 Snx1 0.3 1.2 8.2 2.42E-03 3.90% 1330 10549635 Lilra5 0.4 1.3 7.6 2.42E-03 3.90% 1331 10594066 Loxl1 -0.3 0.8 6.6 2.42E-03 3.90% 1332 10422512 A2ld1 0.3 1.3 11.2 2.42E-03 3.90% 1333 10339051 -0.5 0.7 5.6 2.42E-03 3.90% 1334 10519052 2810405K02Rik -0.3 0.8 7.0 2.42E-03 3.90% 1335 10417517 -0.3 0.8 4.2 2.42E-03 3.90% 1336 10397786 Kif4b 0.4 1.3 5.0 2.42E-03 3.90% 1337 10576413 -0.3 0.8 6.0 2.43E-03 3.90% 1338 10351380 Ildr2 -0.6 0.7 7.1 2.43E-03 3.90% 1339 10447239 Abcg8 -0.8 0.6 9.2 2.43E-03 3.90% 1340 10559478 Lilra6 0.4 1.3 5.1 2.43E-03 3.91% 1341 10532865 Git2 0.2 1.1 8.1 2.44E-03 3.92% 1342 10384795 Cyb5d1 0.3 1.2 8.9 2.45E-03 3.92%

Page 33 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1343 10393823 P4hb 0.2 1.1 12.5 2.45E-03 3.92% 1344 10474497 Olfr1287 0.4 1.4 3.6 2.45E-03 3.92% 1345 10543530 Pax4 -0.3 0.8 6.0 2.45E-03 3.92% 1346 10550768 Vmn1r122 0.4 1.3 3.5 2.46E-03 3.93% 1347 10597823 Lyzl4 -0.2 0.8 5.9 2.46E-03 3.93% 1348 10553521 Gas2 -0.5 0.7 8.2 2.46E-03 3.93% 1349 10583870 Bmper 0.5 1.4 7.5 2.46E-03 3.93% 1350 10358555 Hmcn1 -0.3 0.8 6.3 2.47E-03 3.93% 1351 10510991 Morn1 -0.2 0.9 6.6 2.47E-03 3.93% 1352 10532984 Dynll1 0.5 1.4 9.6 2.48E-03 3.94% 1353 10519951 Pion -0.3 0.8 9.4 2.48E-03 3.95% 1354 10529799 -0.3 0.8 7.3 2.49E-03 3.95% 1355 10583694 0.3 1.2 8.0 2.49E-03 3.95% 1356 10435784 Ndufs5 -0.3 0.8 8.1 2.49E-03 3.95% 1357 10341168 -0.5 0.7 7.3 2.49E-03 3.95% 1358 10363392 Dnajb12 0.2 1.2 9.5 2.50E-03 3.96% 1359 10340923 -0.4 0.8 10.0 2.51E-03 3.97% 1360 10343074 0.9 1.8 5.5 2.51E-03 3.97% 1361 10339495 0.4 1.3 9.9 2.51E-03 3.97% 1362 10593589 -0.5 0.7 5.4 2.51E-03 3.97% 1363 10556491 Far1 0.4 1.3 6.5 2.52E-03 3.97% 1364 10508697 Srsf4 -0.3 0.8 9.3 2.52E-03 3.97% 1365 10588037 Rbp1 -0.4 0.8 8.1 2.52E-03 3.97% 1366 10533120 Rbm19 -0.3 0.8 5.6 2.52E-03 3.97% 1367 10433656 Mkl2 -0.4 0.8 8.5 2.53E-03 3.99% 1368 10518019 Ddi2 -0.2 0.9 10.9 2.54E-03 3.99% 1369 10506424 Actg1 0.6 1.5 11.4 2.54E-03 3.99% 1370 10408083 Hist1h3g 0.8 1.7 10.5 2.54E-03 3.99% 1371 10447904 Unc93a -0.5 0.7 7.8 2.54E-03 3.99% 1372 10541644 Cd163 0.4 1.3 7.0 2.55E-03 3.99% 1373 10538590 Herc6 0.3 1.2 8.6 2.55E-03 3.99% 1374 10509811 Tas1r2 -0.3 0.8 6.2 2.55E-03 3.99% 1375 10552008 Atp4a 0.5 1.4 6.9 2.56E-03 4.00% 1376 10563447 Abcc6 -0.4 0.8 9.5 2.56E-03 4.00% 1377 10363773 Rhobtb1 -0.5 0.7 9.8 2.56E-03 4.00% 1378 10342370 -0.7 0.6 4.7 2.57E-03 4.00% 1379 10461038 Macrod1 -0.3 0.8 7.7 2.57E-03 4.00% 1380 10371012 Lmnb2 0.2 1.2 6.8 2.57E-03 4.01% 1381 10391949 Gosr2 0.3 1.3 9.8 2.58E-03 4.02% 1382 10451918 Ubxn6 -0.2 0.9 8.1 2.59E-03 4.02% 1383 10602385 Pfkfb1 -0.4 0.8 10.0 2.59E-03 4.02%

Page 34 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1384 10363541 Ass1 -0.3 0.8 12.9 2.59E-03 4.02% 1385 10542275 Etv6 0.3 1.3 8.1 2.59E-03 4.02% 1386 10556828 Anks4b 0.4 1.3 8.8 2.59E-03 4.02% 1387 10344380 0.3 1.2 11.5 2.60E-03 4.03% 1388 10508651 Sdc3 0.4 1.3 8.9 2.61E-03 4.04% 1389 10343212 0.4 1.3 10.2 2.61E-03 4.04% 1390 10344610 0.5 1.4 9.9 2.61E-03 4.04% 1391 10505249 -0.4 0.8 7.9 2.61E-03 4.04% 1392 10561956 Rps12 0.3 1.3 9.1 2.62E-03 4.05% 1393 10606138 Dmrtc1c -0.3 0.8 6.9 2.62E-03 4.05% 1394 10371616 Chpt1 -0.5 0.7 10.4 2.64E-03 4.07% 1395 10392284 Kpna2 0.5 1.4 10.4 2.64E-03 4.07% 1396 10604038 Akap17b 0.4 1.3 6.9 2.65E-03 4.08% 1397 10470555 Gbgt1 0.2 1.2 6.6 2.65E-03 4.08% 1398 10555389 Ucp2 0.3 1.3 9.1 2.65E-03 4.08% 1399 10354647 0.5 1.5 5.6 2.65E-03 4.08% 1400 10460423 Spnb3 -0.3 0.8 8.3 2.65E-03 4.08% 1401 10576967 3930402G23Rik -0.3 0.8 5.9 2.66E-03 4.08% 1402 10443561 Ftsjd2 0.2 1.2 8.7 2.66E-03 4.08% 1403 10472549 Bbs5 0.4 1.3 6.6 2.66E-03 4.08% 1404 10554778 Grm5 -0.3 0.8 5.5 2.67E-03 4.09% 1405 10346074 Wdr75 0.5 1.4 8.2 2.68E-03 4.10% 1406 10519655 Gm8912 0.3 1.2 7.7 2.68E-03 4.11% 1407 10368270 Rps12 0.4 1.3 9.1 2.69E-03 4.11% 1408 10367215 Apon 0.4 1.3 11.9 2.69E-03 4.11% 1409 10529068 Slc30a3 -0.2 0.8 6.9 2.69E-03 4.11% 1410 10349782 Nuak2 0.5 1.4 7.9 2.71E-03 4.13% 1411 10578493 Tlr3 0.4 1.3 7.0 2.71E-03 4.13% 1412 10346410 Aox3 -0.4 0.8 10.6 2.71E-03 4.13% 1413 10526145 0610007L01Rik 0.4 1.3 10.8 2.71E-03 4.13% 1414 10578189 -0.3 0.8 6.6 2.71E-03 4.13% 1415 10339561 0.5 1.4 8.4 2.72E-03 4.13% 1416 10356262 Csprs 0.3 1.2 7.5 2.72E-03 4.14% 1417 10500324 Hist2h2aa1 0.3 1.2 10.9 2.72E-03 4.14% 1418 10500329 Hist2h2aa1 0.3 1.3 11.0 2.73E-03 4.14% 1419 10520553 Tmem214 0.4 1.3 10.0 2.74E-03 4.14% 1420 10505237 -0.4 0.8 9.0 2.74E-03 4.14% 1421 10454885 Slc4a9 -0.3 0.8 6.2 2.74E-03 4.14% 1422 10341791 0.6 1.6 5.4 2.74E-03 4.14% 1423 10349014 Capza1 0.4 1.3 10.3 2.74E-03 4.14% 1424 10594540 Plekho2 0.2 1.2 6.8 2.75E-03 4.16%

Page 35 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1425 10502191 Ostc 0.4 1.4 10.7 2.78E-03 4.19% 1426 10537157 Akr1b10 0.4 1.3 6.6 2.78E-03 4.19% 1427 10576246 Rps12 0.4 1.3 9.2 2.78E-03 4.19% 1428 10378637 Scarf1 -0.3 0.8 7.6 2.79E-03 4.20% 1429 10552249 Gm6795 -0.3 0.8 8.3 2.79E-03 4.20% 1430 10475435 Rps12 0.4 1.3 9.8 2.79E-03 4.20% 1431 10474984 Nusap1 1.0 2.0 5.9 2.80E-03 4.20% 1432 10472724 Gorasp2 0.3 1.2 11.0 2.80E-03 4.20% 1433 10424743 Tigd5 -0.2 0.8 7.2 2.80E-03 4.20% 1434 10555233 0.8 1.7 8.0 2.80E-03 4.20% 1435 10584977 Sik3 -0.3 0.8 8.6 2.80E-03 4.20% 1436 10343384 0.8 1.7 8.5 2.81E-03 4.20% 1437 10535849 -0.3 0.8 6.2 2.81E-03 4.20% 1438 10429491 Arc -0.4 0.8 6.6 2.81E-03 4.20% 1439 10415811 Serpine3 -0.2 0.9 6.1 2.81E-03 4.20% 1440 10499639 Cks1b 0.6 1.6 8.2 2.82E-03 4.21% 1441 10591616 Dock6 -0.2 0.9 7.9 2.82E-03 4.21% 1442 10563770 Csrp3 0.4 1.3 8.8 2.83E-03 4.21% 1443 10601285 Dmrtc1c -0.3 0.8 7.0 2.83E-03 4.22% 1444 10408490 Exoc2 0.3 1.2 8.3 2.83E-03 4.22% 1445 10437698 Txndc11 0.6 1.5 8.9 2.84E-03 4.23% 1446 10549552 Prpf31 0.3 1.2 7.7 2.84E-03 4.23% 1447 10344332 -0.3 0.8 9.5 2.85E-03 4.23% 1448 10501832 -0.3 0.8 11.9 2.85E-03 4.23% 1449 10350099 Ptprv -0.3 0.8 6.4 2.85E-03 4.23% 1450 10340693 0.3 1.2 8.1 2.85E-03 4.23% 1451 10342560 -0.8 0.6 5.4 2.85E-03 4.23% 1452 10338709 -0.4 0.8 10.0 2.86E-03 4.24% 1453 10586759 Bnip2 -0.2 0.9 9.8 2.87E-03 4.24% 1454 10414262 Ear2 0.5 1.4 4.5 2.87E-03 4.24% 1455 10354644 Gm6810 -0.2 0.8 5.5 2.87E-03 4.24% 1456 10571342 Rps12 0.4 1.3 9.3 2.87E-03 4.24% 1457 10558265 Lhpp 0.5 1.4 10.4 2.88E-03 4.25% 1458 10572616 Dda1 0.3 1.2 8.7 2.89E-03 4.25% 1459 10362701 Ddo -0.5 0.7 8.2 2.89E-03 4.25% 1460 10569890 Aida 0.3 1.3 8.3 2.89E-03 4.25% 1461 10419082 5730469M10Rik -0.5 0.7 11.3 2.89E-03 4.25% 1462 10431935 Amigo2 0.3 1.2 7.5 2.90E-03 4.25% 1463 10426098 Creld2 1.1 2.1 11.1 2.90E-03 4.25% 1464 10488722 Commd7 0.3 1.3 8.2 2.90E-03 4.25% 1465 10569008 Cox8b -0.9 0.5 6.3 2.90E-03 4.25%

Page 36 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1466 10413304 Arf4 0.4 1.3 10.5 2.90E-03 4.25% 1467 10453512 Kpna2 0.5 1.4 10.3 2.90E-03 4.25% 1468 10539773 Gfpt1 0.7 1.6 8.5 2.91E-03 4.25% 1469 10341844 -0.5 0.7 7.9 2.91E-03 4.25% 1470 10358315 Cfhr1 -0.5 0.7 8.2 2.91E-03 4.26% 1471 10407126 Plk2 0.6 1.5 7.4 2.91E-03 4.26% 1472 10471555 Angptl2 -0.5 0.7 8.6 2.91E-03 4.26% 1473 10377804 Arrb2 0.2 1.2 8.0 2.91E-03 4.26% 1474 10557177 Prkcb 0.3 1.3 7.2 2.92E-03 4.26% 1475 10342450 -0.3 0.8 8.8 2.92E-03 4.26% 1476 10406417 Actg1 0.5 1.4 11.5 2.94E-03 4.28% 1477 10408251 Slc17a4 0.4 1.4 10.0 2.94E-03 4.28% 1478 10342495 0.6 1.5 9.7 2.94E-03 4.28% 1479 10342147 0.8 1.8 5.5 2.94E-03 4.28% 1480 10342359 0.3 1.2 10.0 2.94E-03 4.28% 1481 10548892 Arhgdib 0.5 1.4 7.8 2.95E-03 4.28% 1482 10494390 Hist2h2aa1 0.3 1.2 10.9 2.95E-03 4.28% 1483 10395394 Ispd 0.3 1.2 6.4 2.95E-03 4.28% 1484 10416340 Gfra2 0.3 1.2 5.9 2.96E-03 4.28% 1485 10568553 Chst15 -0.2 0.9 8.2 2.96E-03 4.29% 1486 10504373 -0.4 0.8 5.8 2.96E-03 4.29% 1487 10422728 Dab2 0.4 1.3 9.2 2.97E-03 4.29% 1488 10346191 Stat1 0.4 1.3 8.9 2.97E-03 4.29% 1489 10346960 Ccnyl1 0.6 1.5 6.5 2.97E-03 4.29% 1490 10344147 -0.6 0.7 6.1 2.98E-03 4.29% 1491 10573626 Gpt2 -0.4 0.8 11.1 2.98E-03 4.29% 1492 10338751 -0.3 0.8 8.0 2.98E-03 4.29% 1493 10535502 Aimp2 0.3 1.2 8.2 2.98E-03 4.29% 1494 10541301 Tuba8 -0.3 0.8 6.7 2.99E-03 4.31% 1495 10423498 Dap 0.3 1.2 12.2 2.99E-03 4.31% 1496 10459730 Me2 0.4 1.3 6.8 3.00E-03 4.31% 1497 10547151 Rpl27a 0.2 1.1 11.2 3.00E-03 4.31% 1498 10371502 Fabp3 -0.7 0.6 6.0 3.00E-03 4.31% 1499 10404063 Hist1h2ab 0.6 1.5 4.6 3.00E-03 4.31% 1500 10342123 -0.7 0.6 6.7 3.01E-03 4.32% 1501 10465764 C730048C13Rik 0.3 1.3 11.5 3.03E-03 4.34% 1502 10607870 Tlr7 0.4 1.3 5.5 3.03E-03 4.34% 1503 10484197 -0.4 0.7 8.5 3.04E-03 4.35% 1504 10514956 Scp2 -0.3 0.8 10.8 3.04E-03 4.35% 1505 10533403 Cux2 0.4 1.3 8.2 3.06E-03 4.36% 1506 10468022 Mrpl43 0.2 1.2 8.4 3.06E-03 4.36%

Page 37 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1507 10606658 Trmt2b -0.2 0.9 9.1 3.06E-03 4.37% 1508 10339293 -0.7 0.6 7.3 3.06E-03 4.37% 1509 10428004 Ankrd33b -0.3 0.8 7.5 3.08E-03 4.39% 1510 10339623 -0.4 0.7 7.0 3.08E-03 4.39% 1511 10586184 Tipin 1.0 1.9 7.6 3.09E-03 4.39% 1512 10564313 Mphosph10 0.6 1.5 6.7 3.09E-03 4.39% 1513 10453047 Gm9374 -0.3 0.8 7.5 3.10E-03 4.41% 1514 10530059 Sel1l3 0.4 1.3 7.6 3.11E-03 4.42% 1515 10566875 -0.2 0.8 7.3 3.12E-03 4.43% 1516 10504000 Dnaja1 -0.4 0.8 9.7 3.13E-03 4.44% 1517 10507057 -0.2 0.8 4.5 3.14E-03 4.45% 1518 10432398 Tuba1b 0.5 1.4 11.7 3.14E-03 4.45% 1519 10368041 3110003A17Rik 0.4 1.3 8.0 3.14E-03 4.45% 1520 10415725 Spata13 0.4 1.3 7.6 3.15E-03 4.45% 1521 10367611 -0.2 0.8 5.3 3.15E-03 4.45% 1522 10393754 Actg1 0.6 1.5 11.4 3.15E-03 4.45% 1523 10605392 F8 0.3 1.2 9.3 3.15E-03 4.45% 1524 10442739 Unkl -0.3 0.8 7.3 3.16E-03 4.46% 1525 10338375 0.9 1.9 4.9 3.16E-03 4.46% 1526 10338158 0.8 1.8 3.2 3.17E-03 4.46% 1527 10417065 Rap2a 0.3 1.2 7.9 3.17E-03 4.47% 1528 10477004 0.4 1.4 11.0 3.17E-03 4.47% 1529 10373179 Gli1 -0.2 0.8 6.4 3.18E-03 4.48% 1530 10462623 Ifit1 0.5 1.4 6.9 3.19E-03 4.48% 1531 10350689 Ncf2 0.4 1.3 6.0 3.20E-03 4.49% 1532 10405747 -0.3 0.8 5.5 3.21E-03 4.51% 1533 10338075 0.5 1.4 6.9 3.22E-03 4.52% 1534 10450938 Crisp2 0.3 1.3 5.1 3.22E-03 4.52% 1535 10390574 Fbxl20 -0.4 0.7 8.6 3.23E-03 4.52% 1536 10451493 -0.2 0.9 7.4 3.23E-03 4.52% 1537 10464388 Rps12 0.3 1.3 9.2 3.23E-03 4.52% 1538 10577782 Htra4 0.4 1.3 8.3 3.23E-03 4.52% 1539 10517165 Cd52 0.5 1.4 6.5 3.24E-03 4.53% 1540 10349319 Sctr -0.3 0.8 6.0 3.24E-03 4.53% 1541 10527598 Pomp 0.3 1.2 10.1 3.25E-03 4.53% 1542 10462507 Papss2 -0.3 0.8 12.2 3.25E-03 4.53% 1543 10472916 Cdca7 0.7 1.6 7.7 3.25E-03 4.53% 1544 10343468 0.6 1.5 9.8 3.27E-03 4.55% 1545 10484207 Ccdc141 -0.5 0.7 8.0 3.27E-03 4.55% 1546 10338308 -0.8 0.6 6.9 3.27E-03 4.55% 1547 10461765 Lpxn 0.3 1.2 6.2 3.27E-03 4.55%

Page 38 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1548 10579736 9130011J15Rik 0.2 1.1 9.1 3.27E-03 4.55% 1549 10501762 Snx7 0.4 1.3 9.2 3.27E-03 4.55% 1550 10478967 Cstf1 0.2 1.2 8.6 3.28E-03 4.56% 1551 10400189 0.4 1.3 9.3 3.29E-03 4.56% 1552 10396640 Akap5 -0.3 0.8 6.6 3.30E-03 4.57% 1553 10465790 Taf6l 0.2 1.1 7.6 3.30E-03 4.57% 1554 10463043 Cyp2c37 -0.3 0.8 12.4 3.30E-03 4.57% 1555 10338567 0.4 1.3 9.4 3.30E-03 4.57% 1556 10412624 Pxk 0.3 1.2 9.5 3.31E-03 4.57% 1557 10351259 Slc19a2 -0.5 0.7 9.5 3.31E-03 4.57% 1558 10385526 9930111J21Rik2 0.4 1.3 7.2 3.31E-03 4.57% 1559 10466104 Ccdc86 0.4 1.3 7.9 3.31E-03 4.57% 1560 10476893 Gzf1 0.3 1.2 8.9 3.32E-03 4.58% 1561 10569291 Krtap5-2 -0.4 0.8 5.9 3.33E-03 4.58% 1562 10342950 -0.4 0.7 9.0 3.33E-03 4.58% 1563 10370127 Pcnt -0.2 0.9 6.6 3.33E-03 4.58% 1564 10368886 -0.5 0.7 9.1 3.34E-03 4.59% 1565 10524842 -0.3 0.8 4.9 3.34E-03 4.59% 1566 10361065 Mfsd7b 0.4 1.3 7.4 3.35E-03 4.61% 1567 10396121 4930512B01Rik -0.3 0.8 5.8 3.36E-03 4.61% 1568 10461158 Snhg1 0.5 1.4 6.5 3.36E-03 4.61% 1569 10411454 Sec61b 0.3 1.3 8.7 3.36E-03 4.61% 1570 10340838 0.6 1.5 6.9 3.36E-03 4.61% 1571 10480121 Fam188a 0.3 1.2 8.8 3.37E-03 4.61% 1572 10364841 Izumo4 -0.3 0.8 7.0 3.37E-03 4.61% 1573 10523853 Lpcat2b -0.2 0.8 5.5 3.38E-03 4.62% 1574 10518075 Fhad1 -0.3 0.8 5.9 3.39E-03 4.64% 1575 10588505 Abhd14b -0.3 0.8 9.5 3.40E-03 4.64% 1576 10348119 -0.3 0.8 5.2 3.40E-03 4.64% 1577 10399407 Vsnl1 -0.3 0.8 5.6 3.40E-03 4.64% 1578 10399691 Id2 0.5 1.4 12.3 3.41E-03 4.65% 1579 10573867 Rbl2 -0.3 0.8 8.4 3.42E-03 4.66% 1580 10425116 Cdc42ep1 0.4 1.3 7.7 3.42E-03 4.66% 1581 10356406 Ngef -0.5 0.7 8.6 3.43E-03 4.66% 1582 10561907 Sdhaf1 0.3 1.3 8.0 3.43E-03 4.66% 1583 10559385 Mrgprf -0.3 0.8 5.9 3.43E-03 4.66% 1584 10598794 0.5 1.4 7.4 3.44E-03 4.66% 1585 10365450 Pwp1 0.3 1.3 8.3 3.44E-03 4.66% 1586 10599064 Gm10058 0.5 1.4 4.3 3.44E-03 4.67% 1587 10526049 Mrps17 0.3 1.2 7.0 3.44E-03 4.67% 1588 10379840 Myo19 0.3 1.2 7.7 3.45E-03 4.67%

Page 39 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1589 10509275 Rpl31 0.3 1.2 9.9 3.46E-03 4.68% 1590 10451932 Plin4 -0.3 0.8 6.6 3.46E-03 4.68% 1591 10339270 -0.6 0.6 3.6 3.46E-03 4.68% 1592 10413530 Dcp1a 0.3 1.3 7.1 3.47E-03 4.68% 1593 10341593 0.8 1.7 6.0 3.47E-03 4.68% 1594 10471655 Gsn -0.4 0.7 7.5 3.47E-03 4.69% 1595 10608703 Tomt -0.3 0.8 5.6 3.47E-03 4.69% 1596 10517463 Luzp1 -0.3 0.8 6.4 3.48E-03 4.69% 1597 10601421 A630033H20Rik 0.6 1.5 5.1 3.48E-03 4.69% 1598 10480347 Pip4k2a 0.2 1.2 7.9 3.49E-03 4.70% 1599 10590263 0.4 1.4 5.9 3.49E-03 4.70% 1600 10415086 Psmb11 -0.3 0.8 5.6 3.49E-03 4.70% 1601 10388758 Nek8 -0.3 0.8 6.7 3.50E-03 4.70% 1602 10405355 Unc5a -0.2 0.9 6.1 3.50E-03 4.70% 1603 10380571 Gngt2 0.5 1.4 6.2 3.50E-03 4.70% 1604 10560785 Vmn1r-ps79 0.4 1.3 3.8 3.51E-03 4.70% 1605 10555438 Fchsd2 -0.4 0.8 9.2 3.51E-03 4.70% 1606 10365344 Tcp11l2 -0.7 0.6 7.5 3.51E-03 4.70% 1607 10566366 Trim30d 0.5 1.4 5.6 3.52E-03 4.70% 1608 10545372 Atoh8 -0.4 0.8 8.0 3.52E-03 4.70% 1609 10554370 Zfp710 0.2 1.2 7.4 3.52E-03 4.70% 1610 10342004 -0.6 0.7 8.1 3.52E-03 4.70% 1611 10511999 Gm136 -0.3 0.8 3.7 3.52E-03 4.70% 1612 10523595 Ptpn13 -0.2 0.9 5.8 3.52E-03 4.70% 1613 10605943 Pdzd11 0.3 1.3 8.2 3.52E-03 4.70% 1614 10449452 Fkbp5 -0.7 0.6 9.0 3.54E-03 4.71% 1615 10413419 Arhgef3 -0.3 0.8 8.7 3.54E-03 4.71% 1616 10601531 Ube2dnl -0.4 0.8 3.6 3.56E-03 4.73% 1617 10349295 Tcfcp2l1 0.3 1.2 7.6 3.56E-03 4.74% 1618 10455784 Gramd3 -0.3 0.8 9.5 3.57E-03 4.74% 1619 10418917 Fam25c -0.3 0.8 7.9 3.57E-03 4.74% 1620 10443367 E230001N04Rik -0.6 0.6 5.5 3.57E-03 4.74% 1621 10505246 -0.4 0.8 10.8 3.57E-03 4.74% 1622 10505258 -0.4 0.8 10.8 3.57E-03 4.74% 1623 10495539 Extl2 0.3 1.2 7.1 3.58E-03 4.74% 1624 10603986 Gm10058 0.5 1.4 4.4 3.58E-03 4.74% 1625 10604023 Gm10058 0.5 1.4 4.4 3.58E-03 4.74% 1626 10338705 -0.6 0.6 7.2 3.58E-03 4.74% 1627 10549988 Vmn1r78 -0.3 0.8 3.3 3.59E-03 4.75% 1628 10371379 Nuak1 0.4 1.3 7.1 3.59E-03 4.75% 1629 10575326 -0.2 0.9 7.2 3.60E-03 4.75%

Page 40 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1630 10547888 Gpr162 -0.2 0.9 6.1 3.61E-03 4.76% 1631 10597266 Als2cl -0.3 0.8 5.2 3.61E-03 4.76% 1632 10483626 Dlx2 -0.3 0.8 5.7 3.62E-03 4.77% 1633 10398996 Crip2 0.9 1.9 9.8 3.62E-03 4.77% 1634 10474689 Fam98b 0.4 1.3 7.1 3.63E-03 4.77% 1635 10439021 Senp5 0.3 1.2 8.4 3.63E-03 4.77% 1636 10495285 Sort1 -0.4 0.7 7.9 3.63E-03 4.77% 1637 10454198 Rnf125 -0.6 0.7 11.0 3.63E-03 4.77% 1638 10582020 Gcsh 0.3 1.3 9.4 3.64E-03 4.78% 1639 10446615 Rps24 0.2 1.2 9.6 3.65E-03 4.79% 1640 10557816 Bckdk 0.3 1.2 7.8 3.65E-03 4.79% 1641 10552156 Rhpn2 -0.4 0.8 7.5 3.66E-03 4.79% 1642 10344144 0.6 1.5 6.9 3.66E-03 4.79% 1643 10360158 Ly9 0.3 1.3 6.8 3.67E-03 4.80% 1644 10535704 Cyp3a11 -0.4 0.8 12.8 3.67E-03 4.80% 1645 10453233 Slc8a1 0.3 1.2 5.7 3.67E-03 4.80% 1646 10472809 Dlx1 -0.3 0.8 6.1 3.68E-03 4.81% 1647 10403754 Gpank1 -0.2 0.9 8.0 3.69E-03 4.82% 1648 10407924 Gpank1 -0.2 0.9 8.0 3.69E-03 4.82% 1649 10447897 Wtap 0.4 1.3 6.8 3.71E-03 4.84% 1650 10339229 -0.4 0.7 6.0 3.71E-03 4.84% 1651 10585988 Myo9a 0.3 1.3 6.5 3.71E-03 4.84% 1652 10412713 -0.3 0.8 5.5 3.72E-03 4.84% 1653 10535714 Cyp3a25 -0.3 0.8 12.8 3.72E-03 4.84% 1654 10531415 Cxcl10 0.7 1.6 6.9 3.72E-03 4.84% 1655 10508614 Fabp3 -0.8 0.6 5.8 3.72E-03 4.84% 1656 10540191 Nr2c2 -0.3 0.8 8.4 3.73E-03 4.84% 1657 10380260 Trim25 0.3 1.2 8.8 3.73E-03 4.85% 1658 10450384 Msh5 -0.3 0.8 6.1 3.75E-03 4.86% 1659 10419167 Ptgdr -0.3 0.8 5.4 3.75E-03 4.86% 1660 10419759 Prmt5 0.3 1.2 8.8 3.75E-03 4.86% 1661 10381934 Tanc2 0.3 1.3 7.2 3.75E-03 4.86% 1662 10517731 Igsf21 -0.3 0.8 6.1 3.76E-03 4.86% 1663 10463200 Hoga1 -0.3 0.8 10.9 3.76E-03 4.86% 1664 10465395 Ppp2r5b 0.3 1.2 7.4 3.76E-03 4.86% 1665 10343662 -0.9 0.5 3.3 3.76E-03 4.86% 1666 10592058 Tuba1b 0.4 1.4 11.6 3.77E-03 4.86% 1667 10562989 Cpt1c -0.2 0.9 6.1 3.77E-03 4.86% 1668 10340734 -0.5 0.7 4.1 3.77E-03 4.86% 1669 10370000 Gstt1 -0.3 0.8 11.6 3.78E-03 4.87% 1670 10470936 Tbc1d13 0.3 1.2 8.1 3.79E-03 4.88%

Page 41 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1671 10561453 Zfp36 -0.5 0.7 9.3 3.79E-03 4.88% 1672 10424842 Gm6661 -0.4 0.8 5.5 3.80E-03 4.89% 1673 10488816 Ahcy -0.3 0.8 12.7 3.80E-03 4.89% 1674 10359814 Ildr2 -0.3 0.8 6.6 3.81E-03 4.90% 1675 10448004 Phf10 0.2 1.2 8.4 3.82E-03 4.90% 1676 10393628 Tbc1d16 0.2 1.1 8.3 3.83E-03 4.91% 1677 10509147 Gale 0.4 1.3 7.1 3.83E-03 4.91% 1678 10352756 Lpgat1 0.4 1.4 11.1 3.84E-03 4.92% 1679 10403000 0.4 1.3 3.0 3.86E-03 4.94% 1680 10525766 Gtf2h3 0.3 1.2 7.5 3.86E-03 4.95% 1681 10386115 -0.4 0.7 6.6 3.87E-03 4.95% 1682 10417813 Ecd 0.2 1.2 8.9 3.87E-03 4.95% 1683 10426650 Tuba1c 0.4 1.4 11.7 3.88E-03 4.95% 1684 10355871 Obsl1 -0.3 0.8 6.9 3.88E-03 4.95% 1685 10345089 Mir30c-2 -0.4 0.8 5.2 3.88E-03 4.95% 1686 10517883 Necap2 0.2 1.2 8.4 3.88E-03 4.95% 1687 10343163 0.4 1.3 8.7 3.89E-03 4.95% 1688 10598023 0.6 1.5 11.1 3.89E-03 4.96% 1689 10581957 0610007P22Rik 0.2 1.2 7.3 3.89E-03 4.96% 1690 10466406 -0.3 0.8 6.2 3.90E-03 4.96% 1691 10340998 0.5 1.4 7.3 3.90E-03 4.97% 1692 10339096 1.1 2.1 5.5 3.91E-03 4.97% 1693 10495967 Tifa 0.8 1.7 8.3 3.91E-03 4.97% 1694 10529547 0.3 1.2 8.5 3.91E-03 4.97% 1695 10571621 Ufsp2 0.3 1.2 10.2 3.91E-03 4.97% 1696 10434131 -0.2 0.8 5.1 3.92E-03 4.97% 1697 10548769 Gsg1 -0.2 0.8 6.1 3.92E-03 4.97% 1698 10497831 Ccna2 1.2 2.4 7.0 3.93E-03 4.98% 1699 10342871 -0.6 0.7 8.9 3.94E-03 4.98% 1700 10447634 Gm9992 -0.4 0.7 8.0 3.95E-03 4.99% 1701 10382912 9-Sep 0.3 1.3 9.5 3.95E-03 5.00% 1702 10531484 Ankrd56 0.4 1.3 7.8 3.96E-03 5.01% 1703 10415353 Tssk4 -0.2 0.9 6.5 3.98E-03 5.02% 1704 10409220 Hist2h2aa1 0.3 1.2 11.2 3.98E-03 5.02% 1705 10574098 Nlrc5 0.4 1.3 8.2 3.99E-03 5.03% 1706 10543846 Slc35b4 0.4 1.3 9.2 3.99E-03 5.03% 1707 10340371 0.5 1.4 6.7 3.99E-03 5.03% 1708 10376263 Mfap3 0.2 1.2 8.5 3.99E-03 5.03% 1709 10463164 Frat1 0.3 1.2 7.5 3.99E-03 5.03% 1710 10339750 0.8 1.7 7.1 4.00E-03 5.03% 1711 10440388 Hspa13 0.5 1.4 9.7 4.00E-03 5.03%

Page 42 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1712 10473517 -0.3 0.8 7.8 4.00E-03 5.03% 1713 10505623 D4Bwg0951e -0.5 0.7 10.7 4.00E-03 5.03% 1714 10515930 AA415398 -0.4 0.8 7.0 4.01E-03 5.03% 1715 10427131 Soat2 -0.4 0.8 8.4 4.01E-03 5.03% 1716 10459576 Cep76 0.2 1.2 7.3 4.03E-03 5.04% 1717 10484987 Nr1h3 0.2 1.2 9.9 4.03E-03 5.04% 1718 10469151 Itih5 -0.4 0.8 6.0 4.03E-03 5.04% 1719 10429843 Parp10 0.2 1.2 7.4 4.03E-03 5.04% 1720 10368079 -0.2 0.9 5.4 4.03E-03 5.04% 1721 10396652 Hspa2 -0.4 0.8 6.7 4.04E-03 5.04% 1722 10398831 Inf2 0.3 1.2 7.8 4.05E-03 5.05% 1723 10439895 Alcam -0.2 0.9 10.2 4.06E-03 5.06% 1724 10342553 0.5 1.4 6.4 4.06E-03 5.06% 1725 10597841 Hhatl -0.2 0.8 6.0 4.06E-03 5.06% 1726 10556127 Olfr479 -0.3 0.8 5.2 4.06E-03 5.06% 1727 10338608 -0.6 0.7 6.0 4.07E-03 5.07% 1728 10587683 Bcl2a1a 0.3 1.3 6.0 4.07E-03 5.07% 1729 10482133 Olfr361 -0.3 0.8 4.8 4.07E-03 5.07% 1730 10459241 Afap1l1 -0.2 0.9 6.6 4.07E-03 5.07% 1731 10341107 -0.6 0.7 9.3 4.08E-03 5.07% 1732 10513112 Epb4.1l4b 0.2 1.2 8.1 4.08E-03 5.07% 1733 10455346 Tcerg1 0.4 1.3 7.6 4.08E-03 5.07% 1734 10498992 Tlr2 0.3 1.3 7.2 4.08E-03 5.07% 1735 10395612 G2e3 0.4 1.3 6.8 4.09E-03 5.07% 1736 10528474 Rpl22l1 0.3 1.2 6.4 4.09E-03 5.07% 1737 10586397 Mtfmt 0.3 1.2 8.8 4.10E-03 5.08% 1738 10343886 -0.4 0.7 7.0 4.10E-03 5.08% 1739 10600971 Otud6a -0.3 0.8 6.0 4.12E-03 5.09% 1740 10504518 Polr1e 0.4 1.4 7.3 4.12E-03 5.09% 1741 10519203 Tmem88b -0.4 0.8 6.6 4.12E-03 5.09% 1742 10431017 Ttll1 0.3 1.3 7.1 4.12E-03 5.09% 1743 10517988 Slc25a34 -0.3 0.8 6.5 4.12E-03 5.09% 1744 10565434 Rps13 0.3 1.2 9.3 4.13E-03 5.09% 1745 10386262 Obscn -0.2 0.8 6.1 4.13E-03 5.09% 1746 10393431 Tk1 -0.5 0.7 8.8 4.13E-03 5.09% 1747 10408204 Hist1h2ae 0.3 1.3 3.2 4.13E-03 5.09% 1748 10528143 Ppp1r14b 0.6 1.5 8.5 4.14E-03 5.09% 1749 10504582 1300002K09Rik 0.3 1.3 10.1 4.14E-03 5.09% 1750 10340181 0.3 1.2 8.6 4.15E-03 5.10% 1751 10375382 Clint1 0.2 1.2 10.1 4.16E-03 5.11% 1752 10411949 Rgs7bp -0.2 0.9 5.9 4.17E-03 5.11%

Page 43 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1753 10373467 Erbb3 -0.5 0.7 10.0 4.17E-03 5.11% 1754 10574438 Cdh5 0.2 1.2 9.2 4.17E-03 5.11% 1755 10452213 Gtf2f1 0.4 1.3 8.9 4.17E-03 5.11% 1756 10489253 Zhx3 -0.2 0.8 8.9 4.17E-03 5.11% 1757 10340149 -0.4 0.8 6.1 4.17E-03 5.11% 1758 10442172 Zfp160 0.3 1.2 6.5 4.19E-03 5.13% 1759 10497122 Depdc1a 0.6 1.5 4.3 4.20E-03 5.14% 1760 10515425 Snord38a 0.4 1.3 4.4 4.20E-03 5.14% 1761 10496742 2410004B18Rik 0.3 1.2 6.9 4.21E-03 5.14% 1762 10489545 Tnnc2 -0.6 0.7 6.5 4.22E-03 5.15% 1763 10503170 Chd7 -0.2 0.9 8.8 4.22E-03 5.15% 1764 10507976 Yrdc 0.3 1.2 6.8 4.24E-03 5.17% 1765 10378013 Rpain 0.2 1.2 8.3 4.25E-03 5.17% 1766 10342779 0.3 1.2 11.7 4.25E-03 5.17% 1767 10559467 Pira1 0.4 1.3 6.9 4.25E-03 5.17% 1768 10560730 Vmn1r93 0.4 1.3 4.0 4.25E-03 5.17% 1769 10560783 Vmn1r93 0.4 1.3 4.0 4.25E-03 5.17% 1770 10403903 Trim27 0.3 1.2 8.2 4.27E-03 5.18% 1771 10535559 Baiap2l1 -0.6 0.7 9.2 4.27E-03 5.18% 1772 10466818 Cbwd1 0.3 1.2 6.5 4.27E-03 5.19% 1773 10452535 0.6 1.5 7.3 4.28E-03 5.19% 1774 10343709 -0.5 0.7 5.2 4.28E-03 5.19% 1775 10432378 Lmbr1l -0.3 0.8 7.7 4.28E-03 5.19% 1776 10550770 Vmn1r114 0.4 1.3 4.0 4.30E-03 5.20% 1777 10393177 Acox1 -0.2 0.8 12.7 4.30E-03 5.20% 1778 10602964 -0.3 0.8 6.3 4.30E-03 5.20% 1779 10440491 App -0.2 0.8 10.3 4.31E-03 5.21% 1780 10465342 Tm7sf2 -0.3 0.8 10.5 4.32E-03 5.22% 1781 10548779 Pbp2 -0.3 0.8 5.3 4.33E-03 5.23% 1782 10502776 Lphn2 0.3 1.2 11.0 4.33E-03 5.23% 1783 10557156 Plk1 0.9 1.9 6.9 4.33E-03 5.23% 1784 10519998 Lrrc17 -0.3 0.8 5.8 4.33E-03 5.23% 1785 10338251 -0.6 0.7 7.6 4.34E-03 5.23% 1786 10426244 Mapk8ip2 -0.3 0.8 5.7 4.35E-03 5.23% 1787 10399666 -0.2 0.9 7.2 4.35E-03 5.23% 1788 10517240 Grrp1 -0.3 0.8 6.7 4.36E-03 5.23% 1789 10480912 Lhx3 -0.3 0.8 6.3 4.36E-03 5.23% 1790 10341395 0.6 1.5 8.9 4.36E-03 5.23% 1791 10528482 5031425E22Rik -0.4 0.8 7.5 4.36E-03 5.23% 1792 10344151 0.6 1.5 6.5 4.36E-03 5.23% 1793 10339761 0.7 1.7 4.8 4.36E-03 5.23%

Page 44 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1794 10338671 -0.4 0.7 7.3 4.36E-03 5.23% 1795 10578262 Mir383 -0.3 0.8 7.9 4.38E-03 5.24% 1796 10454478 Polr2d 0.2 1.2 7.2 4.38E-03 5.25% 1797 10580608 -0.2 0.9 5.7 4.39E-03 5.25% 1798 10343885 -0.4 0.8 7.5 4.39E-03 5.25% 1799 10476021 Sirpa 0.3 1.2 8.8 4.39E-03 5.25% 1800 10392012 Cdc27 0.3 1.2 9.7 4.39E-03 5.25% 1801 10450116 Slc39a7 0.3 1.3 8.7 4.39E-03 5.25% 1802 10357856 -0.3 0.8 4.5 4.40E-03 5.25% 1803 10494386 Hist2h2ab 0.3 1.2 10.3 4.40E-03 5.25% 1804 10451458 Cnpy3 0.2 1.2 8.9 4.40E-03 5.25% 1805 10509178 Asap3 -0.3 0.8 7.6 4.41E-03 5.25% 1806 10381668 Nmt1 0.2 1.1 10.2 4.41E-03 5.25% 1807 10561401 Supt5h 0.3 1.2 8.7 4.41E-03 5.25% 1808 10339820 0.3 1.2 9.5 4.42E-03 5.25% 1809 10496204 Cenpe 0.7 1.6 5.3 4.42E-03 5.25% 1810 10340301 -0.6 0.7 6.4 4.43E-03 5.27% 1811 10373902 Gatsl3 -0.3 0.8 6.4 4.44E-03 5.27% 1812 10606026 Zmym3 0.2 1.2 7.2 4.45E-03 5.28% 1813 10341969 0.6 1.5 6.2 4.45E-03 5.28% 1814 10514924 Tomm22 0.3 1.2 9.0 4.46E-03 5.28% 1815 10352916 Mir29b-2 -0.4 0.8 5.2 4.46E-03 5.28% 1816 10585610 Ptpn9 0.3 1.3 8.4 4.46E-03 5.28% 1817 10500054 Psmd4 0.3 1.2 8.9 4.47E-03 5.28% 1818 10510624 Klhl21 -0.4 0.8 8.5 4.47E-03 5.28% 1819 10533246 Oas1g 0.3 1.3 6.8 4.47E-03 5.28% 1820 10379968 Tubd1 0.3 1.2 6.8 4.47E-03 5.28% 1821 10477887 0610011L14Rik 0.2 1.2 7.8 4.48E-03 5.28% 1822 10341399 -0.2 0.9 11.7 4.48E-03 5.28% 1823 10405751 Mir713 -0.4 0.8 5.3 4.49E-03 5.29% 1824 10342800 -0.3 0.8 8.1 4.49E-03 5.29% 1825 10497503 Kpna2 0.5 1.4 10.5 4.49E-03 5.29% 1826 10517336 Clic4 0.4 1.3 10.4 4.50E-03 5.29% 1827 10587780 Tuba1b 0.4 1.4 11.9 4.50E-03 5.29% 1828 10448615 Rab26 -0.3 0.8 6.3 4.51E-03 5.29% 1829 10483698 Wipf1 0.2 1.2 6.8 4.51E-03 5.29% 1830 10380524 Slc35b1 0.5 1.4 10.7 4.51E-03 5.29% 1831 10514133 Ttc39b 0.4 1.3 8.6 4.51E-03 5.29% 1832 10500928 Capza1 0.4 1.3 10.9 4.51E-03 5.29% 1833 10343267 0.6 1.5 6.2 4.52E-03 5.29% 1834 10557975 Slc5a2 -0.3 0.8 6.5 4.52E-03 5.29%

Page 45 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1835 10505028 -0.4 0.7 9.4 4.52E-03 5.29% 1836 10448559 D330041H03Rik -0.3 0.8 5.2 4.52E-03 5.29% 1837 10438272 Prodh -0.7 0.6 10.2 4.52E-03 5.29% 1838 10454674 Srp19 0.4 1.3 7.0 4.52E-03 5.29% 1839 10569786 Pnpla6 0.3 1.3 8.3 4.53E-03 5.29% 1840 10350530 Pdc -0.2 0.9 4.4 4.53E-03 5.29% 1841 10497173 Pxmp3 0.3 1.2 8.5 4.53E-03 5.29% 1842 10568150 Kif22 0.5 1.4 5.9 4.53E-03 5.29% 1843 10436708 Usp16 0.4 1.3 9.0 4.54E-03 5.29% 1844 10464704 Adrbk1 0.2 1.2 8.3 4.54E-03 5.29% 1845 10439854 Bbx 0.3 1.2 7.7 4.55E-03 5.30% 1846 10356489 Asb18 -0.3 0.8 6.2 4.56E-03 5.32% 1847 10585015 Apoa5 -0.3 0.8 11.9 4.57E-03 5.32% 1848 10499902 Sprr4 -0.2 0.8 5.7 4.58E-03 5.32% 1849 10432840 Krt2 -0.3 0.8 4.9 4.58E-03 5.32% 1850 10459530 B430212C06Rik -0.2 0.9 4.6 4.59E-03 5.32% 1851 10460259 Aldh3b2 -0.3 0.8 6.7 4.59E-03 5.32% 1852 10340401 -0.6 0.6 4.8 4.59E-03 5.32% 1853 10363479 Rpl27a 0.2 1.1 10.5 4.59E-03 5.32% 1854 10338107 -0.5 0.7 6.6 4.59E-03 5.32% 1855 10479362 Rps21 0.3 1.2 7.5 4.59E-03 5.32% 1856 10400057 Arl4a -0.3 0.8 6.8 4.60E-03 5.32% 1857 10532332 Pgam5 0.2 1.2 8.0 4.60E-03 5.32% 1858 10554814 Prss23 -0.3 0.8 6.0 4.61E-03 5.32% 1859 10606573 0.4 1.3 10.0 4.61E-03 5.32% 1860 10606567 Rps12 0.4 1.3 10.0 4.61E-03 5.32% 1861 10606569 Rps12 0.4 1.3 10.0 4.61E-03 5.32% 1862 10606577 Rps12 0.4 1.3 10.0 4.61E-03 5.32% 1863 10606579 Rps12 0.4 1.3 10.0 4.61E-03 5.32% 1864 10601593 0.3 1.2 8.9 4.61E-03 5.32% 1865 10519105 Ski 0.4 1.3 8.7 4.62E-03 5.32% 1866 10590688 0.2 1.2 2.7 4.62E-03 5.33% 1867 10463875 Sorcs3 0.6 1.5 6.6 4.63E-03 5.33% 1868 10365132 Nfic -0.2 0.8 7.0 4.63E-03 5.33% 1869 10426598 -0.3 0.8 6.1 4.65E-03 5.35% 1870 10343637 -0.5 0.7 9.2 4.66E-03 5.36% 1871 10401365 Zfyve1 -0.4 0.8 9.3 4.66E-03 5.36% 1872 10598524 Ssxb10 -0.4 0.8 2.9 4.67E-03 5.36% 1873 10584819 -0.3 0.8 8.0 4.67E-03 5.36% 1874 10499981 Oaz3 -0.3 0.8 5.0 4.68E-03 5.37% 1875 10574682 E2f4 0.2 1.2 8.3 4.68E-03 5.37%

Page 46 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1876 10435765 -0.3 0.8 3.9 4.69E-03 5.37% 1877 10375503 Trim7 -0.3 0.8 6.9 4.69E-03 5.37% 1878 10584276 Sec61g 0.3 1.3 9.6 4.69E-03 5.37% 1879 10603051 Ap1s2 0.4 1.3 5.3 4.70E-03 5.37% 1880 10585301 Rdx -0.2 0.9 10.8 4.70E-03 5.37% 1881 10522368 Nipal1 0.4 1.3 9.3 4.70E-03 5.37% 1882 10531061 Ugt2b37 0.6 1.5 11.2 4.71E-03 5.38% 1883 10339878 -0.4 0.7 8.8 4.71E-03 5.38% 1884 10342479 0.8 1.8 5.2 4.71E-03 5.38% 1885 10462866 Cep55 0.7 1.6 5.4 4.71E-03 5.38% 1886 10385814 Leap2 0.6 1.5 7.4 4.72E-03 5.38% 1887 10443817 Pknox1 0.2 1.2 7.2 4.72E-03 5.38% 1888 10564522 -0.3 0.8 4.5 4.72E-03 5.38% 1889 10430096 Lrrc24 -0.2 0.9 7.1 4.73E-03 5.38% 1890 10424667 4930572J05Rik 0.3 1.2 7.3 4.73E-03 5.38% 1891 10376513 Nlrp3 0.3 1.2 5.7 4.73E-03 5.38% 1892 10462796 Kif11 0.9 1.9 6.2 4.74E-03 5.38% 1893 10526564 Ufsp1 0.3 1.2 6.9 4.74E-03 5.38% 1894 10539135 Capg 0.3 1.2 6.1 4.74E-03 5.39% 1895 10370180 Col6a2 -0.3 0.8 6.9 4.75E-03 5.39% 1896 10382328 Sox9 -0.2 0.8 6.8 4.75E-03 5.39% 1897 10526229 -0.3 0.8 6.3 4.76E-03 5.39% 1898 10601335 2610029G23Rik 0.4 1.3 8.0 4.76E-03 5.39% 1899 10413930 Fam170b -0.3 0.8 6.4 4.77E-03 5.40% 1900 10392739 Sdk2 -0.2 0.8 6.2 4.77E-03 5.40% 1901 10365420 AI597468 0.4 1.4 7.4 4.78E-03 5.41% 1902 10557399 Sbk1 0.4 1.4 8.2 4.79E-03 5.41% 1903 10576953 -0.2 0.9 4.7 4.79E-03 5.41% 1904 10473505 Olfr1076 0.3 1.2 3.9 4.79E-03 5.42% 1905 10562709 Cd33 0.3 1.2 6.9 4.80E-03 5.42% 1906 10342874 0.9 1.9 4.6 4.80E-03 5.42% 1907 10408077 Hist1h2ak 0.8 1.7 8.2 4.81E-03 5.42% 1908 10480725 BC029214 0.5 1.4 9.4 4.81E-03 5.42% 1909 10368504 Rpl12 0.2 1.1 12.2 4.81E-03 5.42% 1910 10581167 -0.2 0.8 5.6 4.81E-03 5.42% 1911 10560983 Dedd2 -0.3 0.8 7.4 4.82E-03 5.42% 1912 10382713 Itgb4 -0.2 0.8 6.7 4.83E-03 5.43% 1913 10439788 -0.3 0.8 5.3 4.83E-03 5.43% 1914 10560356 -0.2 0.9 3.2 4.84E-03 5.44% 1915 10410039 Ptch1 -0.3 0.8 8.7 4.85E-03 5.45% 1916 10422707 Prkaa1 0.3 1.2 9.4 4.86E-03 5.46%

Page 47 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1917 10359851 Uck2 0.5 1.4 8.9 4.87E-03 5.46% 1918 10436804 Mrap 0.3 1.3 9.7 4.87E-03 5.46% 1919 10339769 -0.5 0.7 2.3 4.88E-03 5.47% 1920 10437443 5730403B10Rik -0.4 0.7 8.9 4.89E-03 5.48% 1921 10424077 Utp23 0.2 1.2 6.4 4.90E-03 5.48% 1922 10568180 Cd2bp2 0.2 1.2 7.1 4.91E-03 5.48% 1923 10468217 Actr1a 0.3 1.2 8.6 4.91E-03 5.48% 1924 10606565 0.4 1.3 10.0 4.91E-03 5.48% 1925 10606571 0.4 1.3 10.0 4.91E-03 5.48% 1926 10606575 0.4 1.3 10.0 4.91E-03 5.48% 1927 10474769 Bub1b 0.5 1.4 6.1 4.93E-03 5.50% 1928 10599096 Gm10058 0.5 1.4 4.4 4.94E-03 5.51% 1929 10603975 Gm10058 0.5 1.4 4.4 4.94E-03 5.51% 1930 10438347 Tbx1 -0.2 0.9 6.6 4.94E-03 5.51% 1931 10568392 Rgs10 0.3 1.3 8.3 4.95E-03 5.51% 1932 10359734 Dcaf6 -0.3 0.8 8.5 4.95E-03 5.51% 1933 10343028 0.4 1.3 8.9 4.95E-03 5.51% 1934 10373519 Rpl12 0.2 1.2 12.4 4.95E-03 5.51% 1935 10385926 Cdc42se2 0.3 1.2 8.2 4.96E-03 5.51% 1936 10601178 Itgb1bp2 -0.2 0.9 6.2 4.96E-03 5.51% 1937 10469856 Wdr85 0.2 1.2 7.3 4.96E-03 5.51% 1938 10545842 Fbxo41 -0.3 0.8 6.4 4.96E-03 5.51% 1939 10338167 -0.4 0.7 3.7 4.97E-03 5.51% 1940 10369479 Lrrc20 -0.2 0.8 6.5 4.97E-03 5.51% 1941 10340273 -0.5 0.7 7.5 4.97E-03 5.51% 1942 10344713 Ahcy -0.3 0.8 12.9 4.99E-03 5.52% 1943 10461408 Rab3il1 0.2 1.2 7.1 5.00E-03 5.54% 1944 10378508 Tsr1 0.5 1.4 8.1 5.01E-03 5.54% 1945 10428604 Tnfrsf11b 0.4 1.3 7.9 5.01E-03 5.54% 1946 10533729 Vps37b 0.4 1.4 7.7 5.04E-03 5.57% 1947 10579219 Ddx49 0.3 1.2 8.0 5.04E-03 5.57% 1948 10551382 2310022A10Rik 0.2 1.1 7.1 5.04E-03 5.57% 1949 10542340 8430419L09Rik -0.4 0.8 8.4 5.05E-03 5.57% 1950 10379518 Ccl7 0.3 1.2 6.2 5.05E-03 5.57% 1951 10514779 Prkaa2 -0.4 0.8 9.8 5.06E-03 5.58% 1952 10353309 Jph1 -0.3 0.8 5.6 5.07E-03 5.58% 1953 10531370 Naaa 0.4 1.3 7.8 5.07E-03 5.58% 1954 10391649 Slc4a1 0.4 1.3 6.7 5.07E-03 5.58% 1955 10521913 Rbpj 0.2 1.2 8.1 5.08E-03 5.59% 1956 10590487 Zfp660 -0.3 0.8 5.5 5.08E-03 5.59% 1957 10521822 0.3 1.2 4.5 5.09E-03 5.59%

Page 48 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1958 10339172 -0.5 0.7 8.4 5.10E-03 5.59% 1959 10415144 Ngdn 0.3 1.2 7.1 5.10E-03 5.59% 1960 10340846 0.7 1.6 3.6 5.10E-03 5.59% 1961 10597493 Stt3b 0.2 1.2 10.6 5.10E-03 5.59% 1962 10459208 Mir378 -0.3 0.8 5.5 5.10E-03 5.59% 1963 10508711 Taf12 0.3 1.3 7.9 5.10E-03 5.59% 1964 10384824 Prorsd1 0.3 1.3 8.1 5.10E-03 5.59% 1965 10448676 Slc9a3r2 -0.2 0.8 7.8 5.10E-03 5.59% 1966 10341187 -0.5 0.7 7.1 5.11E-03 5.59% 1967 10496032 Rpl12 0.2 1.1 12.0 5.11E-03 5.59% 1968 10435704 Cd80 0.3 1.2 5.9 5.11E-03 5.59% 1969 10476702 Sec23b 0.6 1.6 10.2 5.12E-03 5.59% 1970 10364455 Cdc34 0.3 1.2 8.5 5.12E-03 5.60% 1971 10338120 0.3 1.2 11.1 5.13E-03 5.60% 1972 10344457 0.7 1.7 4.6 5.13E-03 5.60% 1973 10387363 Cyb5d1 0.3 1.2 8.8 5.15E-03 5.61% 1974 10422013 Klf12 -0.4 0.8 9.5 5.15E-03 5.61% 1975 10516529 Adc -0.2 0.9 6.4 5.15E-03 5.61% 1976 10464813 Rbm4 -0.2 0.9 7.4 5.16E-03 5.62% 1977 10560740 Vmn1r121 0.4 1.3 3.5 5.17E-03 5.62% 1978 10560787 Vmn1r121 0.4 1.3 3.5 5.17E-03 5.62% 1979 10425914 Upk3a -0.3 0.8 6.3 5.18E-03 5.62% 1980 10348166 -0.2 0.9 6.2 5.18E-03 5.62% 1981 10608035 Ube1y1 -0.2 0.9 3.4 5.19E-03 5.62% 1982 10608187 Ube1y1 -0.2 0.9 3.4 5.19E-03 5.62% 1983 10584752 Rps25 0.2 1.1 11.2 5.19E-03 5.62% 1984 10575840 LOC100504406 -0.3 0.8 5.4 5.19E-03 5.62% 1985 10359624 Prrx1 -0.3 0.8 5.6 5.19E-03 5.62% 1986 10359034 Qsox1 0.3 1.3 11.2 5.19E-03 5.62% 1987 10385542 Btnl9 -0.2 0.8 7.8 5.20E-03 5.63% 1988 10342356 -0.6 0.7 7.5 5.20E-03 5.63% 1989 10425283 Maff -0.4 0.7 6.6 5.22E-03 5.64% 1990 10340005 0.4 1.3 8.7 5.22E-03 5.64% 1991 10437149 -0.3 0.8 7.7 5.22E-03 5.64% 1992 10480999 Sdccag3 0.2 1.1 9.1 5.24E-03 5.65% 1993 10414738 LOC547323 -0.3 0.8 5.2 5.24E-03 5.65% 1994 10414934 LOC547323 -0.3 0.8 5.2 5.24E-03 5.65% 1995 10510687 Acot7 -0.2 0.8 8.4 5.25E-03 5.66% 1996 10357249 Steap3 -0.3 0.8 7.6 5.26E-03 5.66% 1997 10541094 Zfp637 0.3 1.2 7.7 5.26E-03 5.66% 1998 10598626 Tspan7 0.4 1.3 9.7 5.26E-03 5.66%

Page 49 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

1999 10340361 -0.3 0.8 8.1 5.26E-03 5.66% 2000 10497794 Ccdc144b -0.3 0.8 4.1 5.26E-03 5.66% 2001 10478401 Ttpal 0.3 1.2 8.2 5.26E-03 5.66% 2002 10389816 Tom1l1 0.3 1.2 8.8 5.27E-03 5.66% 2003 10533345 Aldh2 -0.3 0.8 12.0 5.27E-03 5.66% 2004 10427125 Igfbp6 -0.5 0.7 6.1 5.27E-03 5.66% 2005 10450197 Btnl5 -0.5 0.7 6.1 5.28E-03 5.66% 2006 10339896 -0.6 0.6 5.7 5.28E-03 5.66% 2007 10414315 Cdkn3 0.6 1.6 6.2 5.28E-03 5.66% 2008 10462613 Ifit2 0.4 1.4 5.8 5.29E-03 5.66% 2009 10353311 Jph1 -0.3 0.8 5.9 5.29E-03 5.66% 2010 10458016 Proc -0.2 0.8 11.6 5.29E-03 5.66% 2011 10488374 Foxa2 0.4 1.4 7.8 5.30E-03 5.66% 2012 10344074 -0.3 0.8 10.9 5.30E-03 5.66% 2013 10338165 0.9 1.9 4.5 5.30E-03 5.67% 2014 10563116 Flt3l -0.2 0.9 7.7 5.31E-03 5.67% 2015 10359677 Blzf1 0.3 1.2 9.3 5.32E-03 5.68% 2016 10411332 Hmgcr -0.6 0.6 11.0 5.33E-03 5.69% 2017 10380321 Mbtd1 -0.3 0.8 8.5 5.33E-03 5.69% 2018 10532580 Myo18b -0.3 0.8 7.5 5.35E-03 5.70% 2019 10385004 Nprl3 0.2 1.2 8.0 5.35E-03 5.70% 2020 10465244 Malat1 -0.3 0.8 11.9 5.35E-03 5.70% 2021 10384780 Fancl -0.3 0.8 7.7 5.36E-03 5.71% 2022 10338795 0.9 1.8 3.5 5.37E-03 5.71% 2023 10504504 Grhpr -0.3 0.8 10.8 5.37E-03 5.71% 2024 10525296 Brap -0.4 0.7 9.4 5.38E-03 5.71% 2025 10498350 P2ry14 0.3 1.2 6.7 5.38E-03 5.71% 2026 10407327 Emb 0.3 1.3 5.4 5.39E-03 5.72% 2027 10468089 Mgea5 -0.2 0.9 8.6 5.39E-03 5.72% 2028 10606581 Rps12 0.4 1.3 9.9 5.39E-03 5.72% 2029 10509253 4930549C01Rik -0.3 0.8 6.2 5.39E-03 5.72% 2030 10608658 Ost4 0.2 1.2 12.1 5.40E-03 5.72% 2031 10530733 Clock 0.4 1.3 9.0 5.40E-03 5.72% 2032 10463643 0.4 1.3 3.9 5.40E-03 5.72% 2033 10382257 Amz2 0.3 1.2 8.0 5.43E-03 5.74% 2034 10343454 -0.5 0.7 7.5 5.44E-03 5.74% 2035 10495763 Gclm -0.2 0.9 11.9 5.44E-03 5.74% 2036 10598596 Gm14501 -0.3 0.8 5.4 5.44E-03 5.74% 2037 10341693 0.3 1.2 8.4 5.44E-03 5.74% 2038 10604111 Rhox1 -0.3 0.8 6.7 5.44E-03 5.74% 2039 10531193 Adamts3 -0.2 0.8 6.5 5.44E-03 5.74%

Page 50 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2040 10338509 -0.5 0.7 8.6 5.44E-03 5.74% 2041 10394749 Nol10 0.4 1.3 6.9 5.45E-03 5.74% 2042 10487577 Ckap2l 0.8 1.7 6.7 5.46E-03 5.75% 2043 10380252 Coil 0.3 1.2 6.6 5.47E-03 5.76% 2044 10522596 Tmem165 0.3 1.2 8.7 5.47E-03 5.76% 2045 10393851 Pcyt2 -0.3 0.8 10.8 5.48E-03 5.76% 2046 10572861 F2rl3 -0.4 0.7 5.8 5.48E-03 5.76% 2047 10427910 Fam105b 0.2 1.2 9.2 5.49E-03 5.77% 2048 10457884 -0.3 0.8 7.5 5.50E-03 5.77% 2049 10339716 -0.7 0.6 3.1 5.52E-03 5.79% 2050 10469867 Pnpla7 -0.3 0.8 8.6 5.52E-03 5.79% 2051 10439762 Ahcy -0.3 0.8 12.8 5.52E-03 5.79% 2052 10376412 Olfr314 -0.3 0.8 6.7 5.53E-03 5.79% 2053 10529671 Slc2a9 -0.3 0.8 8.8 5.53E-03 5.80% 2054 10559758 Vmn1r65 -0.4 0.8 4.0 5.53E-03 5.80% 2055 10568982 Zfp941 0.3 1.2 6.2 5.54E-03 5.80% 2056 10377681 Ctdnep1 0.2 1.2 8.4 5.55E-03 5.81% 2057 10473632 Olfr1261 -0.3 0.8 3.0 5.56E-03 5.81% 2058 10343566 0.8 1.7 4.9 5.57E-03 5.83% 2059 10518352 Hmgb2 0.6 1.5 6.8 5.59E-03 5.84% 2060 10493259 Ssr2 0.3 1.2 11.6 5.61E-03 5.85% 2061 10601581 9230105E10Rik 0.3 1.2 7.5 5.61E-03 5.86% 2062 10338714 -0.6 0.7 3.1 5.61E-03 5.86% 2063 10529041 Preb 0.4 1.3 9.8 5.62E-03 5.86% 2064 10360090 Ppox 0.3 1.2 8.8 5.62E-03 5.86% 2065 10338492 0.6 1.6 6.3 5.63E-03 5.86% 2066 10535043 Pdgfa 0.3 1.2 8.3 5.65E-03 5.87% 2067 10447337 1700090G07Rik -0.3 0.8 6.7 5.65E-03 5.87% 2068 10407042 Dimt1 0.4 1.3 7.2 5.65E-03 5.87% 2069 10341252 -0.5 0.7 3.5 5.65E-03 5.87% 2070 10552311 0.4 1.3 7.8 5.66E-03 5.87% 2071 10455199 Rell2 -0.2 0.9 5.7 5.66E-03 5.87% 2072 10570429 Zfp828 0.3 1.2 7.8 5.66E-03 5.87% 2073 10567163 Rps13 0.2 1.2 9.3 5.66E-03 5.87% 2074 10398400 Mir543 0.2 1.2 3.1 5.66E-03 5.87% 2075 10500133 Prune 0.3 1.3 8.6 5.66E-03 5.87% 2076 10413174 Rps24 0.2 1.2 9.5 5.68E-03 5.88% 2077 10342095 -0.5 0.7 7.4 5.70E-03 5.90% 2078 10469138 4930412O13Rik -0.3 0.8 5.2 5.70E-03 5.90% 2079 10466266 Olfr1417 -0.3 0.8 5.5 5.71E-03 5.90% 2080 10535608 Kpna7 -0.2 0.9 5.7 5.71E-03 5.91%

Page 51 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2081 10448495 1600002H07Rik -0.3 0.8 8.3 5.72E-03 5.91% 2082 10481155 Rexo4 0.2 1.1 9.0 5.73E-03 5.92% 2083 10484203 -0.4 0.7 7.4 5.74E-03 5.92% 2084 10547030 2510049J12Rik 0.3 1.2 8.4 5.74E-03 5.92% 2085 10339006 0.3 1.3 2.6 5.74E-03 5.92% 2086 10348194 Efhd1 -0.3 0.8 5.6 5.74E-03 5.92% 2087 10376326 Irgm2 0.6 1.5 8.7 5.75E-03 5.92% 2088 10340084 0.9 1.8 6.0 5.75E-03 5.93% 2089 10531304 Cdkl2 -0.3 0.8 6.0 5.76E-03 5.93% 2090 10405779 Mir23b -0.4 0.8 7.4 5.76E-03 5.93% 2091 10338500 -0.6 0.6 7.1 5.76E-03 5.93% 2092 10469425 Arl5b -0.3 0.8 9.7 5.76E-03 5.93% 2093 10505436 Mir455 -0.4 0.8 6.6 5.78E-03 5.94% 2094 10543952 9330158H04Rik -0.2 0.9 4.5 5.79E-03 5.94% 2095 10477187 Tpx2 0.8 1.7 6.0 5.79E-03 5.94% 2096 10420385 N6amt2 0.4 1.3 7.2 5.79E-03 5.94% 2097 10602840 Sh3kbp1 0.2 1.2 7.0 5.79E-03 5.94% 2098 10493307 0.6 1.5 7.4 5.80E-03 5.94% 2099 10575693 Vat1l -0.3 0.8 4.8 5.81E-03 5.95% 2100 10514049 Nfib -0.4 0.8 9.5 5.81E-03 5.95% 2101 10511795 Prdm13 -0.3 0.8 5.8 5.81E-03 5.95% 2102 10342748 0.8 1.7 6.0 5.81E-03 5.95% 2103 10508883 1810019J16Rik -0.2 0.8 6.7 5.82E-03 5.95% 2104 10475772 Stard7 -0.2 0.9 9.6 5.82E-03 5.95% 2105 10585990 Myo9a 0.5 1.4 7.2 5.83E-03 5.95% 2106 10546977 Atp2b2 0.3 1.3 6.9 5.83E-03 5.95% 2107 10406530 Tmem167 0.5 1.4 8.8 5.83E-03 5.95% 2108 10590452 Abhd5 0.3 1.2 9.3 5.83E-03 5.95% 2109 10561153 Cyp2b23 -0.4 0.7 6.1 5.84E-03 5.95% 2110 10424381 -0.4 0.8 9.5 5.85E-03 5.95% 2111 10593981 Cyp1a2 -0.3 0.8 12.4 5.85E-03 5.95% 2112 10599075 Gm10058 0.6 1.5 4.5 5.85E-03 5.95% 2113 10599107 Gm10058 0.6 1.5 4.5 5.85E-03 5.95% 2114 10603964 Gm10058 0.6 1.5 4.5 5.85E-03 5.95% 2115 10603997 Gm10058 0.6 1.5 4.5 5.85E-03 5.95% 2116 10604008 Gm10058 0.6 1.5 4.5 5.85E-03 5.95% 2117 10464612 Cabp4 -0.4 0.8 6.3 5.85E-03 5.95% 2118 10478572 Ube2c 0.9 1.8 7.6 5.86E-03 5.95% 2119 10442629 Spsb3 0.3 1.3 7.2 5.86E-03 5.95% 2120 10560709 Pvr 0.2 1.2 7.1 5.87E-03 5.96% 2121 10342052 0.3 1.3 9.6 5.88E-03 5.96%

Page 52 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2122 10591630 Dock6 -0.3 0.8 7.6 5.89E-03 5.97% 2123 10502552 Clca1 0.4 1.3 6.3 5.89E-03 5.97% 2124 10389238 Dusp14 -0.3 0.8 7.4 5.89E-03 5.97% 2125 10598238 0.5 1.4 6.2 5.91E-03 5.98% 2126 10605571 Gyk -0.3 0.8 9.7 5.91E-03 5.98% 2127 10579872 Tpd52 0.3 1.3 7.0 5.91E-03 5.98% 2128 10349512 Ubxn4 0.4 1.3 10.0 5.92E-03 5.98% 2129 10538781 Gm8479 -0.3 0.8 5.2 5.92E-03 5.98% 2130 10400710 Gm71 0.2 1.2 7.3 5.93E-03 5.98% 2131 10574451 Bean1 -0.2 0.8 6.0 5.93E-03 5.98% 2132 10376324 Gm12250 0.5 1.5 7.2 5.93E-03 5.98% 2133 10545409 Vamp8 -0.2 0.9 10.1 5.93E-03 5.98% 2134 10482528 Neb 0.8 1.7 8.8 5.95E-03 6.00% 2135 10515744 Cdc20 0.7 1.6 6.7 5.96E-03 6.00% 2136 10389331 Znhit3 0.3 1.2 6.2 5.96E-03 6.01% 2137 10490852 -0.3 0.8 8.9 5.97E-03 6.01% 2138 10524515 Myo1h -0.2 0.9 5.7 5.98E-03 6.01% 2139 10338986 0.3 1.2 2.2 5.98E-03 6.01% 2140 10482500 Rnd3 0.4 1.3 8.4 5.99E-03 6.01% 2141 10434067 Smpd4 0.2 1.2 7.6 5.99E-03 6.01% 2142 10523281 11-Sep 0.5 1.4 8.9 5.99E-03 6.01% 2143 10569102 Irf7 0.3 1.2 7.1 6.00E-03 6.01% 2144 10494583 Sec22b 0.3 1.3 9.7 6.00E-03 6.01% 2145 10567216 Rps15a 0.3 1.3 7.6 6.00E-03 6.01% 2146 10568930 1810014F10Rik -0.2 0.9 7.1 6.00E-03 6.01% 2147 10397895 Ubr7 0.2 1.2 7.8 6.01E-03 6.01% 2148 10354003 Mgat4a 0.5 1.4 5.4 6.01E-03 6.01% 2149 10512111 Smu1 0.3 1.2 8.7 6.01E-03 6.01% 2150 10574478 Dync1li2 -0.2 0.9 7.0 6.01E-03 6.01% 2151 10457221 -0.2 0.8 5.7 6.01E-03 6.01% 2152 10400483 Slc25a21 -0.4 0.8 8.6 6.02E-03 6.02% 2153 10342061 -0.7 0.6 3.7 6.03E-03 6.02% 2154 10561942 Kirrel2 -0.2 0.9 6.5 6.04E-03 6.04% 2155 10341354 -0.5 0.7 6.8 6.05E-03 6.04% 2156 10581865 Ldhd 0.3 1.2 9.8 6.06E-03 6.04% 2157 10394102 Wdr45l 0.4 1.3 9.3 6.06E-03 6.04% 2158 10344658 Rb1cc1 -0.2 0.8 8.5 6.08E-03 6.05% 2159 10446549 Tmem200c -0.3 0.8 5.2 6.08E-03 6.05% 2160 10377782 Clec10a 0.3 1.3 5.8 6.08E-03 6.05% 2161 10435457 Parp9 0.3 1.2 9.1 6.08E-03 6.06% 2162 10585825 Stoml1 -0.2 0.9 6.8 6.09E-03 6.06%

Page 53 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2163 10537657 Ephb6 -0.3 0.8 6.5 6.10E-03 6.06% 2164 10526452 2310043J07Rik -0.2 0.8 5.9 6.10E-03 6.06% 2165 10599530 Rab33a -0.2 0.8 3.7 6.11E-03 6.07% 2166 10499216 Pear1 -0.2 0.9 7.0 6.11E-03 6.07% 2167 10548701 Lrp6 -0.3 0.8 9.7 6.11E-03 6.07% 2168 10454873 4930471G03Rik -0.3 0.8 6.1 6.11E-03 6.07% 2169 10600355 Snora70 0.3 1.2 7.3 6.12E-03 6.07% 2170 10468231 Arl3 -0.2 0.9 8.6 6.12E-03 6.07% 2171 10401667 0610007P14Rik -0.3 0.8 11.7 6.13E-03 6.07% 2172 10431564 Cpt1b -0.4 0.8 6.5 6.13E-03 6.07% 2173 10512847 Alg2 0.5 1.4 8.4 6.14E-03 6.08% 2174 10355742 Abcb6 -0.3 0.8 9.1 6.15E-03 6.08% 2175 10487969 Trmt6 0.3 1.2 7.2 6.16E-03 6.09% 2176 10535669 Cyp3a41b 0.2 1.1 13.2 6.17E-03 6.09% 2177 10407929 Pou6f2 -0.3 0.8 5.8 6.17E-03 6.09% 2178 10478048 Lbp 0.6 1.5 11.7 6.17E-03 6.09% 2179 10506470 1700024P16Rik 0.4 1.3 6.7 6.17E-03 6.09% 2180 10390707 Top2a 1.2 2.4 6.5 6.17E-03 6.09% 2181 10341172 -0.4 0.8 7.2 6.17E-03 6.09% 2182 10338116 0.5 1.5 8.1 6.18E-03 6.09% 2183 10345698 Rpl31 0.2 1.2 10.5 6.19E-03 6.10% 2184 10542407 Pde6h -0.2 0.9 6.0 6.20E-03 6.11% 2185 10360504 Mir350 0.3 1.3 4.8 6.21E-03 6.11% 2186 10346843 Nrp2 0.3 1.3 8.3 6.22E-03 6.11% 2187 10400383 2700097O09Rik 0.4 1.3 7.4 6.23E-03 6.11% 2188 10341579 0.4 1.3 6.9 6.23E-03 6.11% 2189 10589685 Lrrc2 -0.3 0.8 5.5 6.23E-03 6.11% 2190 10559454 Pira11 0.2 1.2 7.8 6.23E-03 6.11% 2191 10468253 Nt5c2 -0.2 0.9 8.8 6.23E-03 6.11% 2192 10498273 Tm4sf1 0.3 1.2 7.8 6.23E-03 6.11% 2193 10367221 Apof 0.2 1.1 12.6 6.24E-03 6.11% 2194 10459071 2010002N04Rik 0.3 1.2 5.9 6.24E-03 6.11% 2195 10491191 Rpl22l1 0.3 1.2 6.5 6.25E-03 6.13% 2196 10473125 Itga4 0.3 1.3 6.6 6.27E-03 6.14% 2197 10409629 -0.4 0.8 7.6 6.27E-03 6.14% 2198 10476033 Stk35 -0.3 0.8 8.9 6.27E-03 6.14% 2199 10477737 Gdf5 -0.4 0.8 5.3 6.28E-03 6.14% 2200 10604053 Nkrf 0.4 1.3 7.4 6.28E-03 6.14% 2201 10365714 Sec61g 0.3 1.2 10.1 6.29E-03 6.14% 2202 10552037 Sbsn -0.2 0.9 5.8 6.29E-03 6.15% 2203 10562073 Rbm42 0.3 1.2 8.3 6.30E-03 6.15%

Page 54 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2204 10389865 Nme1 0.3 1.2 8.9 6.32E-03 6.16% 2205 10342534 -0.4 0.7 8.3 6.32E-03 6.16% 2206 10571870 Hmgb2 0.6 1.5 6.9 6.32E-03 6.16% 2207 10526952 Gpr30 -0.3 0.8 5.9 6.33E-03 6.16% 2208 10461164 Wdr74 0.3 1.2 8.3 6.33E-03 6.17% 2209 10338482 -0.4 0.7 9.5 6.34E-03 6.17% 2210 10558583 Zfp511 -0.2 0.9 8.3 6.35E-03 6.18% 2211 10344277 -0.4 0.7 8.5 6.39E-03 6.21% 2212 10556962 Vwa3a -0.2 0.9 5.1 6.39E-03 6.21% 2213 10506454 C8b -0.5 0.7 11.4 6.39E-03 6.21% 2214 10445977 Ebi3 0.3 1.2 6.2 6.39E-03 6.21% 2215 10433311 Mgrn1 -0.2 0.9 9.1 6.39E-03 6.21% 2216 10363669 Dnajc12 1.4 2.6 9.1 6.40E-03 6.21% 2217 10388861 Tmem199 0.4 1.3 7.2 6.40E-03 6.21% 2218 10481518 Ptges 0.3 1.2 6.6 6.40E-03 6.21% 2219 10381619 Adam11 -0.3 0.8 6.6 6.40E-03 6.21% 2220 10450272 Cyp21a1 -0.2 0.9 5.5 6.41E-03 6.21% 2221 10405013 Ippk 0.4 1.3 7.0 6.42E-03 6.21% 2222 10509526 Kif17 -0.3 0.8 6.2 6.42E-03 6.21% 2223 10474875 Casc5 0.9 1.9 6.1 6.42E-03 6.21% 2224 10394914 Iah1 -0.2 0.9 9.3 6.43E-03 6.21% 2225 10387559 Senp3 0.3 1.2 8.0 6.44E-03 6.23% 2226 10521205 Sh3bp2 0.3 1.2 8.0 6.44E-03 6.23% 2227 10354816 Clk1 -0.2 0.9 9.8 6.45E-03 6.23% 2228 10608677 Tox4 0.2 1.2 9.1 6.47E-03 6.25% 2229 10349562 AA986860 -0.3 0.8 5.9 6.48E-03 6.25% 2230 10341629 -0.8 0.6 5.3 6.48E-03 6.25% 2231 10560078 Mzf1 -0.3 0.8 5.5 6.48E-03 6.25% 2232 10576911 Efnb2 0.3 1.2 6.8 6.48E-03 6.25% 2233 10597531 Rbms3 -0.2 0.8 6.9 6.49E-03 6.25% 2234 10398025 Serpina3a -0.4 0.8 5.7 6.50E-03 6.26% 2235 10468174 Pitx3 -0.3 0.8 6.7 6.50E-03 6.26% 2236 10503926 Rars2 0.4 1.3 8.6 6.51E-03 6.26% 2237 10342870 0.5 1.4 8.6 6.51E-03 6.26% 2238 10343352 0.7 1.7 5.8 6.52E-03 6.26% 2239 10392822 0.5 1.4 7.1 6.52E-03 6.26% 2240 10598456 Otud5 -0.2 0.9 8.5 6.53E-03 6.27% 2241 10540679 Il17re -0.2 0.9 6.3 6.54E-03 6.27% 2242 10560354 Kctd20 0.3 1.2 7.0 6.55E-03 6.29% 2243 10499777 Ints3 0.2 1.2 8.3 6.56E-03 6.29% 2244 10538150 Tmem176a 0.3 1.2 10.5 6.56E-03 6.29%

Page 55 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2245 10379594 Unc45b -0.2 0.8 6.0 6.56E-03 6.29% 2246 10376507 Zkscan17 -0.2 0.9 6.8 6.57E-03 6.29% 2247 10505562 Gm428 -0.2 0.8 5.2 6.58E-03 6.29% 2248 10340185 -0.3 0.8 7.5 6.58E-03 6.29% 2249 10468974 Cdnf -0.2 0.8 5.5 6.58E-03 6.29% 2250 10584634 Usp2 -0.6 0.6 9.3 6.58E-03 6.29% 2251 10351035 Gas5 0.6 1.5 7.0 6.59E-03 6.30% 2252 10425601 Tef -0.4 0.7 9.1 6.60E-03 6.30% 2253 10478299 L3mbtl -0.3 0.8 6.7 6.61E-03 6.31% 2254 10577544 Polb 0.3 1.3 7.9 6.62E-03 6.32% 2255 10437687 Litaf 0.5 1.5 9.6 6.63E-03 6.32% 2256 10341237 -0.8 0.6 4.3 6.65E-03 6.34% 2257 10468213 -0.2 0.9 5.7 6.65E-03 6.34% 2258 10574584 -0.2 0.9 4.7 6.65E-03 6.34% 2259 10585703 Rpp25 -0.3 0.8 5.5 6.66E-03 6.34% 2260 10608715 2310042D19Rik -0.2 0.9 6.0 6.66E-03 6.34% 2261 10342944 -0.4 0.7 7.2 6.68E-03 6.36% 2262 10486833 Ell3 -0.3 0.8 5.8 6.69E-03 6.36% 2263 10512061 Taf9 0.3 1.2 9.2 6.70E-03 6.37% 2264 10442649 Mapk8ip3 -0.3 0.8 6.2 6.71E-03 6.37% 2265 10455948 Chsy3 0.3 1.2 7.7 6.72E-03 6.38% 2266 10540034 Aldh1l1 -0.3 0.8 12.1 6.72E-03 6.38% 2267 10603914 Gm5168 0.4 1.3 3.6 6.73E-03 6.38% 2268 10424126 Deptor -0.3 0.8 10.2 6.74E-03 6.39% 2269 10552587 Klk1b21 0.3 1.3 6.3 6.76E-03 6.41% 2270 10398011 Serpina4-ps1 -2.2 0.2 9.4 6.76E-03 6.41% 2271 10427918 Fam105a 0.3 1.2 6.0 6.77E-03 6.41% 2272 10368689 Wisp3 -0.3 0.8 6.1 6.77E-03 6.41% 2273 10391454 Vat1 0.2 1.2 8.7 6.77E-03 6.41% 2274 10380415 0.3 1.2 7.8 6.77E-03 6.41% 2275 10380238 Mrps23 0.2 1.2 8.3 6.78E-03 6.41% 2276 10507250 Pomgnt1 0.3 1.2 7.8 6.79E-03 6.41% 2277 10477644 Trp53inp2 -0.4 0.8 10.6 6.79E-03 6.42% 2278 10444407 Ager -0.3 0.8 6.6 6.80E-03 6.42% 2279 10529977 Ppargc1a -0.5 0.7 7.0 6.80E-03 6.42% 2280 10432675 0.3 1.2 5.9 6.81E-03 6.42% 2281 10390869 Krt39 -0.3 0.8 4.6 6.81E-03 6.42% 2282 10590182 Exog 0.4 1.3 6.0 6.82E-03 6.42% 2283 10569618 Ano1 -0.2 0.8 6.0 6.82E-03 6.42% 2284 10505908 -0.4 0.8 6.7 6.82E-03 6.42% 2285 10408346 0.3 1.3 6.6 6.82E-03 6.42%

Page 56 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2286 10598075 0.8 1.8 10.5 6.82E-03 6.42% 2287 10433480 Rpl39l -0.2 0.9 4.0 6.83E-03 6.42% 2288 10491399 Mrpl47 0.4 1.3 5.5 6.84E-03 6.43% 2289 10413795 Eaf1 0.2 1.1 8.4 6.85E-03 6.44% 2290 10451943 Plin5 -0.4 0.8 7.9 6.85E-03 6.44% 2291 10552562 Klk1b1 -0.3 0.8 3.8 6.86E-03 6.44% 2292 10585970 Myo9a 0.5 1.5 8.9 6.86E-03 6.44% 2293 10529935 0.3 1.3 2.9 6.87E-03 6.44% 2294 10349953 Chit1 -0.3 0.8 5.1 6.88E-03 6.44% 2295 10340012 -0.7 0.6 5.6 6.88E-03 6.44% 2296 10560548 Gemin7 0.2 1.2 8.3 6.88E-03 6.44% 2297 10569014 Ifitm2 0.2 1.2 11.2 6.88E-03 6.44% 2298 10595863 Trim42 -0.3 0.8 5.7 6.89E-03 6.44% 2299 10604327 Dcaf12l2 -0.2 0.9 5.5 6.89E-03 6.45% 2300 10397244 Rnf113a2 0.4 1.3 7.2 6.90E-03 6.45% 2301 10432820 Krt72-ps -0.3 0.8 5.5 6.91E-03 6.45% 2302 10350742 Rnasel 0.3 1.2 6.4 6.91E-03 6.45% 2303 10536845 Flnc -0.3 0.8 6.2 6.92E-03 6.46% 2304 10343560 -0.4 0.8 9.9 6.92E-03 6.46% 2305 10515558 Artn -0.2 0.8 5.6 6.93E-03 6.46% 2306 10467637 Arhgap19 0.4 1.3 5.9 6.93E-03 6.46% 2307 10572290 Nr2c2ap 0.3 1.3 8.0 6.93E-03 6.46% 2308 10367400 Mmp19 0.2 1.1 10.0 6.94E-03 6.46% 2309 10342206 0.5 1.5 6.0 6.94E-03 6.46% 2310 10353135 Ncoa2 -0.2 0.8 8.7 6.94E-03 6.47% 2311 10578064 Rpl27a 0.2 1.1 10.9 6.95E-03 6.47% 2312 10400324 -0.2 0.8 4.8 6.95E-03 6.47% 2313 10504417 Hrct1 -0.2 0.9 6.8 6.96E-03 6.47% 2314 10584013 -0.3 0.8 5.5 6.96E-03 6.47% 2315 10521698 -0.3 0.8 8.8 6.97E-03 6.47% 2316 10456400 Tubb6 0.6 1.5 7.8 6.97E-03 6.48% 2317 10520513 4930471M23Rik 0.2 1.2 9.1 6.99E-03 6.49% 2318 10510034 Casp9 -0.2 0.8 7.5 7.00E-03 6.49% 2319 10377416 2310047M10Rik 0.3 1.2 7.0 7.00E-03 6.49% 2320 10386185 Olfr331 -0.2 0.8 6.0 7.00E-03 6.49% 2321 10339781 -0.4 0.8 9.4 7.00E-03 6.49% 2322 10562592 Gm5114 -0.4 0.7 5.9 7.01E-03 6.49% 2323 10358593 Hmcn1 -0.3 0.8 5.7 7.02E-03 6.50% 2324 10509204 Tcea3 -0.3 0.8 9.2 7.02E-03 6.50% 2325 10410973 4833422C13Rik -0.3 0.8 5.1 7.03E-03 6.50% 2326 10504349 Creb3 0.3 1.3 9.4 7.03E-03 6.50%

Page 57 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2327 10414960 -0.2 0.9 6.7 7.04E-03 6.50% 2328 10448582 Mlst8 0.3 1.2 7.5 7.04E-03 6.50% 2329 10447264 Slc3a1 0.8 1.7 9.9 7.04E-03 6.50% 2330 10468251 -0.2 0.9 6.3 7.05E-03 6.51% 2331 10369885 Cisd1 -0.3 0.8 10.9 7.05E-03 6.51% 2332 10571128 Prosc -0.2 0.9 9.3 7.07E-03 6.52% 2333 10387903 Vmo1 0.3 1.2 6.7 7.07E-03 6.52% 2334 10556200 Rpl27a 0.2 1.1 10.7 7.07E-03 6.52% 2335 10517600 Pink1 -0.2 0.8 9.8 7.09E-03 6.53% 2336 10525942 Glt1d1 -0.5 0.7 7.0 7.09E-03 6.53% 2337 10415081 -0.7 0.6 6.1 7.10E-03 6.53% 2338 10520121 -0.7 0.6 6.1 7.10E-03 6.53% 2339 10578405 -0.7 0.6 6.1 7.10E-03 6.53% 2340 10586076 -0.7 0.6 6.1 7.10E-03 6.53% 2341 10461334 Mta2 0.2 1.1 9.2 7.13E-03 6.55% 2342 10346634 Nop58 0.6 1.5 7.6 7.13E-03 6.55% 2343 10378438 1.0 2.0 7.3 7.14E-03 6.55% 2344 10583905 7-Sep 0.3 1.3 9.6 7.16E-03 6.56% 2345 10361375 Fbxo5 0.4 1.3 5.7 7.16E-03 6.56% 2346 10499130 Rnu73b 1.0 1.9 8.1 7.18E-03 6.58% 2347 10356170 -0.4 0.7 10.5 7.18E-03 6.58% 2348 10342196 0.4 1.3 9.3 7.19E-03 6.58% 2349 10434754 BC106179 -0.3 0.8 6.4 7.21E-03 6.60% 2350 10341687 -0.4 0.7 8.2 7.21E-03 6.60% 2351 10381770 4933407P14Rik -0.3 0.8 5.9 7.21E-03 6.60% 2352 10605644 -0.2 0.9 6.2 7.21E-03 6.60% 2353 10577508 Ckap2 0.8 1.8 6.4 7.22E-03 6.60% 2354 10407946 Stard3nl 0.3 1.3 7.8 7.22E-03 6.60% 2355 10375515 Ifi47 0.5 1.4 6.7 7.22E-03 6.60% 2356 10460237 Unc93b1 0.2 1.2 8.3 7.22E-03 6.60% 2357 10436841 Il10rb 0.3 1.3 7.7 7.23E-03 6.60% 2358 10354309 Col5a2 -0.2 0.9 6.2 7.23E-03 6.60% 2359 10380965 Gsdma2 -0.2 0.9 4.0 7.24E-03 6.60% 2360 10564377 Lrrk1 -0.2 0.9 7.6 7.24E-03 6.60% 2361 10342242 0.7 1.6 6.1 7.24E-03 6.60% 2362 10339779 -0.4 0.8 10.7 7.24E-03 6.60% 2363 10569389 -0.3 0.8 6.1 7.25E-03 6.60% 2364 10482004 AI182371 0.1 1.1 12.3 7.26E-03 6.60% 2365 10344520 0.7 1.6 3.9 7.26E-03 6.61% 2366 10608635 -0.2 0.9 5.4 7.27E-03 6.61% 2367 10416732 Snora30 -0.3 0.8 6.7 7.28E-03 6.61%

Page 58 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2368 10557703 Snora30 -0.3 0.8 6.7 7.28E-03 6.61% 2369 10455249 -0.2 0.9 6.0 7.29E-03 6.62% 2370 10597648 Myd88 0.3 1.2 8.9 7.29E-03 6.62% 2371 10360985 Cenpf 0.5 1.4 5.8 7.31E-03 6.63% 2372 10416510 Nufip1 0.3 1.2 8.7 7.31E-03 6.63% 2373 10374558 -0.3 0.8 4.4 7.32E-03 6.63% 2374 10527268 Pms2 0.3 1.2 6.6 7.32E-03 6.63% 2375 10338956 0.7 1.6 3.7 7.33E-03 6.64% 2376 10510604 Dnajc11 0.2 1.2 8.4 7.34E-03 6.64% 2377 10544885 Fkbp14 0.5 1.4 7.2 7.34E-03 6.65% 2378 10355534 Tns1 -0.3 0.8 8.7 7.35E-03 6.65% 2379 10344960 Tmem70 0.2 1.2 8.9 7.36E-03 6.65% 2380 10338977 -0.4 0.8 8.3 7.36E-03 6.65% 2381 10341372 -0.5 0.7 9.7 7.37E-03 6.66% 2382 10406982 Adamts6 -0.4 0.7 5.6 7.37E-03 6.66% 2383 10458583 Yipf5 0.3 1.3 10.0 7.38E-03 6.66% 2384 10568221 Sephs2 -0.2 0.8 11.8 7.39E-03 6.66% 2385 10425161 Lgals1 0.5 1.4 8.7 7.39E-03 6.66% 2386 10352661 Ptpn14 -0.2 0.9 7.0 7.40E-03 6.66% 2387 10343544 0.5 1.4 8.1 7.40E-03 6.66% 2388 10468533 Gpam -0.3 0.8 10.7 7.41E-03 6.66% 2389 10600235 Abcd1 0.3 1.3 8.2 7.41E-03 6.66% 2390 10343521 0.3 1.3 9.2 7.41E-03 6.66% 2391 10481337 1700101E01Rik -0.3 0.8 6.1 7.41E-03 6.66% 2392 10413047 Plau 0.3 1.2 5.4 7.41E-03 6.66% 2393 10500204 Ecm1 -0.3 0.8 10.0 7.42E-03 6.67% 2394 10589503 2610002I17Rik -0.2 0.9 6.1 7.42E-03 6.67% 2395 10423629 Pop1 0.3 1.2 7.0 7.43E-03 6.67% 2396 10563441 Emp3 0.3 1.3 7.8 7.43E-03 6.67% 2397 10342199 -0.3 0.8 7.8 7.44E-03 6.67% 2398 10366938 Stac3 -0.3 0.8 5.8 7.44E-03 6.68% 2399 10382701 Sap30bp 0.2 1.2 8.9 7.45E-03 6.68% 2400 10516213 Akirin1 0.3 1.2 8.5 7.45E-03 6.68% 2401 10343974 0.4 1.4 9.3 7.46E-03 6.68% 2402 10440729 Krtap7-1 -0.2 0.9 5.5 7.46E-03 6.68% 2403 10570666 0.2 1.2 10.2 7.46E-03 6.68% 2404 10345203 Paox -0.3 0.8 8.4 7.47E-03 6.68% 2405 10421870 Gm10845 -0.3 0.8 5.6 7.48E-03 6.68% 2406 10393648 Sgsh 0.2 1.2 7.6 7.48E-03 6.68% 2407 10447254 Ppm1b -0.2 0.9 8.1 7.48E-03 6.68% 2408 10598652 Gm14484 -0.2 0.8 5.9 7.48E-03 6.68%

Page 59 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2409 10553568 Tubgcp5 0.4 1.3 7.0 7.49E-03 6.69% 2410 10338921 -0.8 0.6 5.6 7.49E-03 6.69% 2411 10489349 Gtsf1l -0.3 0.8 5.3 7.50E-03 6.69% 2412 10573691 Gm10638 -0.3 0.8 6.9 7.51E-03 6.70% 2413 10457007 Pqlc1 0.2 1.2 7.9 7.51E-03 6.70% 2414 10419366 -0.3 0.8 4.9 7.53E-03 6.71% 2415 10338074 -0.3 0.8 10.1 7.54E-03 6.71% 2416 10569288 Krtap5-4 -0.3 0.8 8.8 7.55E-03 6.72% 2417 10392803 Cd300c -0.2 0.9 6.1 7.55E-03 6.72% 2418 10480744 Lcn12 0.2 1.2 7.3 7.55E-03 6.72% 2419 10340257 -0.5 0.7 7.1 7.56E-03 6.72% 2420 10542981 Gmfg 0.3 1.2 8.2 7.57E-03 6.72% 2421 10574598 Ces3a -0.2 0.9 12.7 7.57E-03 6.72% 2422 10526101 4930579G22Rik -0.2 0.9 6.0 7.59E-03 6.74% 2423 10579607 Cnot8 -0.4 0.8 6.6 7.60E-03 6.74% 2424 10399426 0.3 1.2 4.0 7.60E-03 6.74% 2425 10547322 Cacna1c -0.2 0.9 5.6 7.60E-03 6.74% 2426 10419713 Olfr1512 -0.3 0.8 4.6 7.61E-03 6.74% 2427 10343240 0.8 1.8 3.8 7.61E-03 6.74% 2428 10550786 Vmn1r132 0.3 1.2 4.6 7.61E-03 6.74% 2429 10393714 2410002I01Rik 0.2 1.2 7.8 7.62E-03 6.74% 2430 10377319 Myh10 -0.2 0.8 6.9 7.62E-03 6.74% 2431 10339161 0.4 1.3 9.1 7.62E-03 6.74% 2432 10592734 Cbl 0.2 1.2 8.1 7.62E-03 6.74% 2433 10597173 Nradd -0.2 0.9 6.6 7.64E-03 6.75% 2434 10435767 -0.3 0.8 3.7 7.64E-03 6.75% 2435 10579828 Rps25 0.2 1.1 11.2 7.65E-03 6.75% 2436 10477061 Srxn1 0.3 1.2 8.7 7.66E-03 6.75% 2437 10569085 Lrrc56 -0.3 0.8 5.8 7.66E-03 6.75% 2438 10338903 0.5 1.4 2.9 7.66E-03 6.75% 2439 10372082 Nudt4 -0.3 0.8 10.6 7.67E-03 6.75% 2440 10344470 0.6 1.5 6.4 7.67E-03 6.75% 2441 10604447 Gpr119 -0.2 0.8 5.3 7.67E-03 6.75% 2442 10342346 0.6 1.5 5.8 7.67E-03 6.75% 2443 10547676 Vmn2r23 0.2 1.2 3.3 7.67E-03 6.75% 2444 10587871 Paqr9 0.4 1.3 11.5 7.67E-03 6.75% 2445 10427744 Rai14 0.3 1.2 8.7 7.68E-03 6.75% 2446 10433702 Mpv17l -0.4 0.7 8.8 7.68E-03 6.75% 2447 10583942 Thyn1 0.4 1.3 8.3 7.68E-03 6.75% 2448 10531407 Cxcl9 0.6 1.5 8.5 7.70E-03 6.76% 2449 10420316 Atp12a -0.2 0.9 7.8 7.70E-03 6.76%

Page 60 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2450 10375570 Olfr1383 -0.3 0.8 6.1 7.71E-03 6.77% 2451 10461663 Mrpl16 0.3 1.3 10.2 7.71E-03 6.77% 2452 10527934 0.4 1.4 6.2 7.72E-03 6.77% 2453 10340038 0.4 1.3 8.6 7.74E-03 6.78% 2454 10402514 Tcl1 -0.3 0.8 5.1 7.74E-03 6.78% 2455 10488959 6430550D23Rik -0.3 0.8 7.1 7.76E-03 6.79% 2456 10521709 Lap3 -0.2 0.9 11.7 7.76E-03 6.79% 2457 10413497 Selk 0.3 1.3 6.3 7.76E-03 6.79% 2458 10586174 0.7 1.6 7.6 7.76E-03 6.79% 2459 10510260 Nppb -0.2 0.8 6.3 7.76E-03 6.79% 2460 10360840 Mosc1 -0.2 0.8 12.0 7.76E-03 6.79% 2461 10559486 Lair1 0.4 1.3 6.5 7.77E-03 6.79% 2462 10441342 Synj2bp -0.2 0.9 10.4 7.77E-03 6.79% 2463 10409643 Hnrnpa0 -0.3 0.8 7.3 7.78E-03 6.79% 2464 10366579 Cdc5l 0.3 1.2 8.1 7.78E-03 6.79% 2465 10372728 Cdc5l 0.3 1.2 8.1 7.78E-03 6.79% 2466 10401443 Fam161b -0.2 0.9 5.8 7.79E-03 6.79% 2467 10570651 Defa21 -0.3 0.8 6.3 7.79E-03 6.79% 2468 10338412 0.4 1.3 5.3 7.82E-03 6.81% 2469 10590844 Arhgap42 -0.2 0.8 10.9 7.83E-03 6.82% 2470 10491551 Exosc9 0.5 1.4 8.2 7.86E-03 6.85% 2471 10344389 0.4 1.3 10.0 7.87E-03 6.85% 2472 10341946 0.6 1.6 5.5 7.87E-03 6.85% 2473 10343776 0.8 1.8 3.8 7.88E-03 6.85% 2474 10567034 Pth -0.2 0.9 3.1 7.88E-03 6.85% 2475 10581340 Ranbp10 -0.3 0.8 9.0 7.88E-03 6.85% 2476 10487886 Adra1d -0.2 0.8 6.7 7.89E-03 6.85% 2477 10374590 Xpo1 0.3 1.3 8.8 7.89E-03 6.85% 2478 10378240 P2rx1 -0.2 0.9 5.4 7.90E-03 6.85% 2479 10391572 Lsm12 0.2 1.1 11.1 7.90E-03 6.85% 2480 10501358 Sars 0.2 1.1 9.5 7.91E-03 6.86% 2481 10561047 Cxcl17 -0.3 0.8 6.5 7.91E-03 6.86% 2482 10427293 Hoxc6 -0.3 0.8 5.0 7.92E-03 6.86% 2483 10439058 Lrrc33 0.3 1.2 6.2 7.92E-03 6.86% 2484 10458419 Slc25a2 -0.3 0.8 5.7 7.93E-03 6.87% 2485 10359113 Fam163a -0.2 0.8 5.3 7.93E-03 6.87% 2486 10397364 Mfsd7c 0.6 1.5 7.6 7.96E-03 6.88% 2487 10341974 -1.2 0.4 4.7 7.96E-03 6.88% 2488 10389162 Rpl12 0.2 1.2 12.3 7.96E-03 6.88% 2489 10420080 Mdp1 0.3 1.2 7.1 7.97E-03 6.89% 2490 10600836 Msn 0.3 1.3 8.5 7.97E-03 6.89%

Page 61 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2491 10499655 Il6ra -0.4 0.8 9.9 7.98E-03 6.89% 2492 10502766 Lphn2 0.4 1.3 6.7 7.98E-03 6.89% 2493 10543333 Aass -0.2 0.9 11.8 7.99E-03 6.89% 2494 10490903 Car13 0.3 1.3 5.8 7.99E-03 6.89% 2495 10487643 Rpl27a 0.2 1.1 11.0 8.00E-03 6.89% 2496 10523518 Enoph1 0.2 1.1 7.0 8.00E-03 6.89% 2497 10343255 0.2 1.2 11.7 8.00E-03 6.89% 2498 10342756 -0.4 0.8 8.1 8.01E-03 6.89% 2499 10518350 Hmgb2 0.5 1.5 7.0 8.01E-03 6.89% 2500 10410501 Irx1 -0.2 0.9 6.4 8.01E-03 6.89% 2501 10473367 Slc43a1 0.3 1.3 8.8 8.02E-03 6.90% 2502 10557139 Ubfd1 0.3 1.2 9.1 8.02E-03 6.90% 2503 10551836 Cox7a1 -0.4 0.8 6.1 8.04E-03 6.90% 2504 10339504 -0.6 0.6 6.8 8.04E-03 6.90% 2505 10496748 Syde2 -0.4 0.7 7.4 8.05E-03 6.91% 2506 10371591 4930547N16Rik 0.4 1.3 5.4 8.05E-03 6.91% 2507 10599120 Dock11 0.3 1.3 6.5 8.06E-03 6.91% 2508 10353574 Col19a1 -0.3 0.8 5.9 8.07E-03 6.92% 2509 10608657 Eef1g 0.2 1.2 9.9 8.07E-03 6.92% 2510 10402336 Ddx24 0.2 1.2 8.3 8.08E-03 6.93% 2511 10386191 Olfr329-ps -0.3 0.8 5.3 8.09E-03 6.93% 2512 10431874 Slc38a1 0.3 1.2 6.3 8.09E-03 6.93% 2513 10557308 -0.2 0.8 6.7 8.10E-03 6.93% 2514 10452892 Fam98a 0.5 1.4 9.3 8.11E-03 6.93% 2515 10462535 Pten 0.5 1.4 7.2 8.11E-03 6.93% 2516 10573910 Irx5 -0.3 0.8 6.0 8.11E-03 6.93% 2517 10442584 Rpl3l -0.3 0.8 5.1 8.12E-03 6.94% 2518 10536141 Ctdnep1 0.2 1.2 7.3 8.13E-03 6.94% 2519 10562627 Ctdnep1 0.2 1.2 7.3 8.13E-03 6.94% 2520 10574872 4933405L10Rik -0.3 0.8 6.0 8.14E-03 6.94% 2521 10434165 Arvcf -0.2 0.9 7.4 8.14E-03 6.94% 2522 10491945 Rab33b 0.2 1.1 7.7 8.15E-03 6.94% 2523 10484706 Olfr74 -0.2 0.8 3.8 8.15E-03 6.94% 2524 10570706 Defa20 -0.2 0.9 6.8 8.15E-03 6.94% 2525 10347362 Mir26b -0.3 0.8 5.7 8.15E-03 6.94% 2526 10359793 Dusp27 -0.3 0.8 5.2 8.15E-03 6.94% 2527 10443836 Rrp1b 0.3 1.2 7.0 8.15E-03 6.94% 2528 10411107 Cmya5 -0.5 0.7 5.9 8.18E-03 6.96% 2529 10394209 Dnmt3a 0.3 1.2 7.6 8.18E-03 6.96% 2530 10552125 Pepd 0.2 1.1 9.2 8.20E-03 6.97% 2531 10351063 -0.3 0.8 7.8 8.21E-03 6.97%

Page 62 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2532 10424746 Zfp623 0.3 1.2 7.9 8.21E-03 6.97% 2533 10341619 -0.6 0.7 3.9 8.21E-03 6.97% 2534 10503484 Fam82b -0.3 0.8 8.4 8.22E-03 6.97% 2535 10422635 C6 0.4 1.3 8.2 8.22E-03 6.97% 2536 10354832 Ppil3 0.2 1.2 8.2 8.22E-03 6.97% 2537 10465587 Fermt3 0.2 1.2 7.0 8.23E-03 6.97% 2538 10416290 Reep4 0.4 1.3 8.3 8.23E-03 6.97% 2539 10408081 Hist1h1b 0.5 1.4 7.4 8.23E-03 6.97% 2540 10481291 Gtf3c5 0.3 1.2 6.8 8.24E-03 6.97% 2541 10554665 Gm7957 -0.3 0.8 3.2 8.24E-03 6.97% 2542 10504294 Rusc2 -0.3 0.8 7.3 8.28E-03 7.01% 2543 10499512 Mir92b -0.3 0.8 7.3 8.29E-03 7.01% 2544 10513208 Svep1 -0.2 0.9 6.2 8.30E-03 7.02% 2545 10434930 -0.3 0.8 7.1 8.31E-03 7.02% 2546 10587150 Myo5c -0.2 0.9 5.5 8.31E-03 7.02% 2547 10563883 Depdc1a 0.5 1.4 4.2 8.32E-03 7.02% 2548 10370210 Col6a1 -0.3 0.8 6.9 8.32E-03 7.02% 2549 10598081 0.7 1.7 8.9 8.32E-03 7.02% 2550 10412826 -0.2 0.9 3.6 8.33E-03 7.02% 2551 10385175 Wwc1 0.3 1.2 8.6 8.33E-03 7.02% 2552 10507163 Cyp4a10 0.4 1.4 12.1 8.34E-03 7.02% 2553 10608136 0.7 1.6 9.0 8.34E-03 7.02% 2554 10538273 BC022713 -0.3 0.8 5.1 8.34E-03 7.02% 2555 10579703 Cherp 0.2 1.1 8.0 8.34E-03 7.02% 2556 10367626 1700052N19Rik 0.4 1.3 7.5 8.36E-03 7.03% 2557 10559221 Tnnt3 -1.0 0.5 6.9 8.36E-03 7.03% 2558 10545807 Spr -0.2 0.9 9.1 8.36E-03 7.03% 2559 10409434 Lman2 0.2 1.1 11.1 8.37E-03 7.03% 2560 10594315 Fem1b 0.2 1.2 8.9 8.37E-03 7.03% 2561 10383429 Npb -0.3 0.8 6.0 8.37E-03 7.03% 2562 10448483 Ntn3 -0.3 0.8 6.6 8.38E-03 7.03% 2563 10598646 Gm14484 -0.2 0.9 6.0 8.40E-03 7.04% 2564 10409021 Tpmt -0.2 0.9 12.0 8.40E-03 7.04% 2565 10518455 Agtrap 0.2 1.2 6.9 8.40E-03 7.04% 2566 10588007 Tfdp2 -0.3 0.8 8.8 8.40E-03 7.04% 2567 10406881 Smn1 0.3 1.2 6.7 8.41E-03 7.05% 2568 10592182 9230110F15Rik -0.5 0.7 4.5 8.41E-03 7.05% 2569 10498620 Trim59 0.5 1.4 4.6 8.41E-03 7.05% 2570 10565709 B3gnt6 -0.3 0.8 5.4 8.42E-03 7.05% 2571 10582572 1.0 1.9 5.4 8.43E-03 7.05% 2572 10406399 Pou5f2 -0.3 0.8 6.1 8.43E-03 7.05%

Page 63 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2573 10510172 Hmgb2 0.5 1.5 6.7 8.44E-03 7.05% 2574 10473919 Ckap5 0.2 1.2 7.9 8.45E-03 7.06% 2575 10522934 Amtn -0.3 0.8 4.4 8.45E-03 7.06% 2576 10472946 Hoxd13 -0.3 0.8 5.7 8.46E-03 7.06% 2577 10563421 Grin2d -0.2 0.8 5.7 8.47E-03 7.06% 2578 10433055 Mir688 -0.3 0.8 6.4 8.47E-03 7.06% 2579 10342974 -0.5 0.7 6.8 8.47E-03 7.06% 2580 10409376 Hk3 0.2 1.2 6.1 8.47E-03 7.06% 2581 10581212 Mir328 -0.3 0.8 7.9 8.47E-03 7.06% 2582 10578027 Mak16 0.3 1.3 7.8 8.48E-03 7.06% 2583 10375501 Snord95 0.4 1.3 7.1 8.48E-03 7.06% 2584 10545237 0.6 1.6 3.2 8.49E-03 7.07% 2585 10430873 Cyp2d34 -0.3 0.8 5.9 8.50E-03 7.07% 2586 10424607 Ptp4a3 0.2 1.2 8.1 8.51E-03 7.08% 2587 10360382 Ifi204 0.5 1.4 6.9 8.52E-03 7.08% 2588 10519324 Cdk6 -0.3 0.8 8.9 8.53E-03 7.09% 2589 10410366 Zfp738 0.2 1.2 6.5 8.54E-03 7.09% 2590 10513722 Tnfsf15 -0.2 0.9 5.7 8.54E-03 7.09% 2591 10418004 Ap3m1 -0.3 0.8 10.7 8.54E-03 7.09% 2592 10341242 0.5 1.4 9.6 8.57E-03 7.11% 2593 10411491 Tnpo1 -0.2 0.9 9.5 8.58E-03 7.12% 2594 10468722 Gfra1 -0.5 0.7 10.1 8.59E-03 7.12% 2595 10448247 Zfp40 0.4 1.3 6.6 8.59E-03 7.12% 2596 10451248 Tjap1 0.2 1.1 7.0 8.60E-03 7.12% 2597 10474312 Pax6 -0.2 0.8 5.4 8.61E-03 7.13% 2598 10397530 1810035L17Rik 0.3 1.2 9.2 8.62E-03 7.13% 2599 10568369 Cox6a2 -0.4 0.8 6.9 8.65E-03 7.16% 2600 10338759 0.5 1.4 8.3 8.65E-03 7.16% 2601 10356677 Myeov2 0.2 1.2 9.1 8.66E-03 7.16% 2602 10545283 Smyd1 0.2 1.2 6.5 8.66E-03 7.16% 2603 10380250 2210409E12Rik -0.2 0.9 6.6 8.66E-03 7.16% 2604 10344562 0.5 1.4 7.0 8.67E-03 7.16% 2605 10560045 Slc27a5 -0.3 0.8 11.9 8.68E-03 7.16% 2606 10591087 Mtnr1b -0.2 0.9 6.0 8.68E-03 7.17% 2607 10505282 Prpf4 0.2 1.2 7.8 8.68E-03 7.17% 2608 10340799 -0.4 0.8 10.6 8.69E-03 7.17% 2609 10342228 -0.5 0.7 5.3 8.70E-03 7.17% 2610 10535006 BC037034 0.3 1.2 7.2 8.70E-03 7.17% 2611 10388545 Abr 0.3 1.2 6.6 8.71E-03 7.17% 2612 10453759 -0.5 0.7 5.4 8.71E-03 7.18% 2613 10435321 Ropn1 -0.2 0.9 4.8 8.76E-03 7.21%

Page 64 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2614 10338812 0.3 1.2 10.4 8.77E-03 7.21% 2615 10341486 -0.8 0.6 3.0 8.77E-03 7.21% 2616 10420013 Nrl -0.3 0.8 5.4 8.77E-03 7.21% 2617 10338810 -0.5 0.7 8.1 8.77E-03 7.21% 2618 10443814 -0.3 0.8 5.9 8.77E-03 7.21% 2619 10363445 4632428N05Rik 0.2 1.2 7.3 8.78E-03 7.21% 2620 10339725 0.8 1.7 3.1 8.78E-03 7.21% 2621 10339932 -0.6 0.7 6.0 8.79E-03 7.21% 2622 10414807 Gm16454 -0.6 0.7 4.5 8.80E-03 7.22% 2623 10342339 -0.3 0.8 8.0 8.81E-03 7.22% 2624 10342548 -0.3 0.8 10.3 8.82E-03 7.23% 2625 10566333 9230105E10Rik 0.3 1.2 7.0 8.83E-03 7.23% 2626 10489406 Rims4 0.4 1.3 7.7 8.84E-03 7.23% 2627 10369040 Ros1 -0.3 0.8 5.3 8.84E-03 7.23% 2628 10548573 Styk1 -0.3 0.8 5.4 8.84E-03 7.23% 2629 10436781 Gm10789 -0.2 0.9 5.5 8.84E-03 7.23% 2630 10340819 -0.7 0.6 4.5 8.84E-03 7.23% 2631 10484361 Zswim2 -0.2 0.8 4.8 8.84E-03 7.23% 2632 10597162 Klhl18 0.2 1.1 7.1 8.84E-03 7.23% 2633 10343692 -0.6 0.7 6.4 8.85E-03 7.23% 2634 10423663 Vps13b -0.2 0.9 9.1 8.86E-03 7.23% 2635 10453429 Pigf 0.2 1.2 7.1 8.86E-03 7.23% 2636 10364237 -0.3 0.8 6.6 8.87E-03 7.24% 2637 10395312 Twistnb 0.4 1.3 7.7 8.89E-03 7.25% 2638 10338163 0.2 1.2 10.2 8.89E-03 7.25% 2639 10435508 2010005H15Rik 0.2 1.2 3.5 8.89E-03 7.25% 2640 10340164 0.5 1.4 5.7 8.90E-03 7.25% 2641 10405587 Tgfbi 0.3 1.2 9.4 8.90E-03 7.25% 2642 10525780 Tctn2 -0.2 0.9 6.6 8.92E-03 7.26% 2643 10351037 Gas5 0.7 1.6 9.1 8.92E-03 7.26% 2644 10550822 Vmn1r179 0.3 1.2 3.3 8.92E-03 7.26% 2645 10567131 Nup35 0.4 1.3 8.0 8.93E-03 7.26% 2646 10364249 -0.2 0.8 6.7 8.93E-03 7.26% 2647 10520800 Gpn1 0.3 1.2 6.6 8.94E-03 7.26% 2648 10591357 Eif3g 0.2 1.2 10.2 8.95E-03 7.27% 2649 10471858 -0.3 0.8 5.9 8.96E-03 7.27% 2650 10381860 Mettl2 0.2 1.2 8.3 8.98E-03 7.29% 2651 10499545 Efna3 -0.2 0.8 5.6 8.98E-03 7.29% 2652 10585978 Myo9a 0.5 1.4 5.7 8.99E-03 7.29% 2653 10520622 Abhd1 -0.2 0.8 10.2 8.99E-03 7.29% 2654 10552356 0.2 1.2 2.4 8.99E-03 7.29%

Page 65 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2655 10552252 1600014C10Rik -0.3 0.8 10.2 9.00E-03 7.29% 2656 10394809 -0.3 0.8 6.5 9.00E-03 7.29% 2657 10394816 -0.3 0.8 6.5 9.00E-03 7.29% 2658 10554789 Ctsc 0.3 1.2 11.4 9.02E-03 7.30% 2659 10581674 Sf3b3 0.2 1.2 9.4 9.03E-03 7.31% 2660 10579976 Elmod2 0.3 1.2 9.2 9.03E-03 7.31% 2661 10398130 Ak7 0.2 1.1 5.4 9.04E-03 7.31% 2662 10464084 Tcf7l2 0.2 1.2 8.8 9.07E-03 7.33% 2663 10356082 Plscr1 0.3 1.3 9.8 9.08E-03 7.33% 2664 10476569 2310003L22Rik 0.2 1.2 5.8 9.08E-03 7.33% 2665 10394735 Pdia6 0.3 1.3 11.1 9.09E-03 7.33% 2666 10471741 Olfr339 0.3 1.2 3.1 9.09E-03 7.33% 2667 10548345 Klrk1 0.3 1.2 4.7 9.09E-03 7.33% 2668 10344011 -0.2 0.9 10.7 9.10E-03 7.33% 2669 10418895 Zfp488 -0.3 0.8 6.6 9.11E-03 7.34% 2670 10407792 Gpr137b-ps 0.3 1.3 6.7 9.12E-03 7.35% 2671 10341189 0.3 1.2 10.3 9.12E-03 7.35% 2672 10340396 0.8 1.7 5.6 9.13E-03 7.35% 2673 10531383 Sdad1 0.3 1.3 6.8 9.14E-03 7.35% 2674 10428827 Tmem65 0.3 1.3 8.0 9.15E-03 7.36% 2675 10395932 Ctage5 -0.2 0.9 11.1 9.15E-03 7.36% 2676 10505543 Gm428 -0.2 0.9 5.2 9.16E-03 7.36% 2677 10397081 Rbm25 -0.4 0.7 8.0 9.16E-03 7.36% 2678 10416940 Tpm3 0.2 1.1 11.0 9.16E-03 7.36% 2679 10538356 Chn2 -0.2 0.9 9.8 9.16E-03 7.36% 2680 10427303 Hoxc4 -0.3 0.8 4.1 9.17E-03 7.36% 2681 10367746 Sash1 -0.4 0.8 8.5 9.17E-03 7.36% 2682 10380589 0.3 1.2 5.4 9.19E-03 7.36% 2683 10571860 Hand2 -0.2 0.9 7.0 9.19E-03 7.36% 2684 10423496 -0.2 0.9 2.9 9.19E-03 7.36% 2685 10500798 2410024N13Rik -0.6 0.7 8.2 9.20E-03 7.37% 2686 10424674 -0.2 0.9 7.0 9.21E-03 7.38% 2687 10359890 Nuf2 0.7 1.6 5.5 9.23E-03 7.38% 2688 10417950 Ndst2 0.2 1.1 8.6 9.23E-03 7.38% 2689 10473760 Celf1 -0.2 0.9 9.9 9.25E-03 7.40% 2690 10412177 Skiv2l2 0.3 1.2 8.3 9.27E-03 7.41% 2691 10520109 -0.3 0.8 5.1 9.27E-03 7.41% 2692 10395893 Sip1 -0.3 0.8 8.4 9.28E-03 7.41% 2693 10524874 Vsig10 -0.2 0.8 6.7 9.28E-03 7.41% 2694 10408477 E2f3 0.3 1.2 7.1 9.28E-03 7.41% 2695 10418903 Gprin2 -0.3 0.8 7.3 9.29E-03 7.41%

Page 66 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2696 10573693 Rps13 0.3 1.2 9.2 9.30E-03 7.42% 2697 10603953 Gm5169 0.4 1.3 4.3 9.32E-03 7.43% 2698 10476347 AU019990 -0.2 0.9 5.9 9.33E-03 7.43% 2699 10428698 Sntb1 -0.3 0.8 10.1 9.35E-03 7.45% 2700 10342893 0.4 1.3 10.0 9.35E-03 7.45% 2701 10479026 Rae1 0.2 1.2 8.2 9.36E-03 7.45% 2702 10342399 -0.5 0.7 8.0 9.38E-03 7.46% 2703 10506883 Rab3b 0.3 1.2 5.9 9.38E-03 7.46% 2704 10538438 Fam188b -0.2 0.9 6.1 9.40E-03 7.47% 2705 10578136 -0.9 0.6 3.1 9.40E-03 7.47% 2706 10475625 Eid1 0.4 1.3 7.1 9.42E-03 7.49% 2707 10606979 Nup62cl -0.4 0.7 5.1 9.43E-03 7.49% 2708 10415875 Pinx1 0.6 1.5 7.9 9.43E-03 7.49% 2709 10372060 Cradd 0.3 1.2 8.3 9.44E-03 7.49% 2710 10358670 Hmcn1 -0.3 0.8 6.0 9.44E-03 7.49% 2711 10594322 Pias1 0.2 1.2 9.2 9.45E-03 7.50% 2712 10351041 0.9 1.8 7.2 9.45E-03 7.50% 2713 10574145 Nlrc5 0.4 1.3 6.1 9.46E-03 7.50% 2714 10533316 Erp29 0.2 1.2 7.8 9.46E-03 7.50% 2715 10339795 -0.6 0.7 4.4 9.47E-03 7.51% 2716 10565132 -0.3 0.8 5.6 9.49E-03 7.51% 2717 10464659 Rad9 0.3 1.2 6.8 9.50E-03 7.52% 2718 10559415 Leng1 0.2 1.2 6.4 9.50E-03 7.52% 2719 10339368 -0.5 0.7 5.5 9.51E-03 7.52% 2720 10544732 Skap2 0.3 1.3 7.7 9.51E-03 7.52% 2721 10357133 0.6 1.5 6.5 9.52E-03 7.52% 2722 10545891 Cml1 -0.4 0.7 9.5 9.54E-03 7.54% 2723 10526482 Polr2j 0.2 1.2 10.1 9.55E-03 7.54% 2724 10429407 -0.3 0.8 5.8 9.56E-03 7.55% 2725 10431802 Twf1 0.2 1.1 10.4 9.58E-03 7.57% 2726 10391963 Nsf 0.2 1.2 8.3 9.60E-03 7.57% 2727 10403511 Heatr1 0.3 1.3 8.3 9.60E-03 7.57% 2728 10596409 Gm7455 -0.3 0.8 6.6 9.61E-03 7.57% 2729 10439520 -0.2 0.8 3.7 9.61E-03 7.57% 2730 10555744 Olfr564 -0.2 0.9 4.1 9.61E-03 7.57% 2731 10462473 Mbl2 0.3 1.2 11.4 9.62E-03 7.58% 2732 10339982 -0.3 0.8 9.6 9.62E-03 7.58% 2733 10599598 -0.3 0.8 4.7 9.64E-03 7.59% 2734 10591009 Med17 0.2 1.1 7.5 9.64E-03 7.59% 2735 10398267 Evl 0.2 1.2 7.9 9.65E-03 7.59% 2736 10516966 BC013712 0.3 1.3 7.0 9.65E-03 7.59%

Page 67 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2737 10428338 Dpys -0.3 0.8 10.3 9.66E-03 7.59% 2738 10503845 Ube2j1 0.2 1.2 10.1 9.67E-03 7.60% 2739 10342930 -0.3 0.8 6.9 9.71E-03 7.63% 2740 10503650 -0.2 0.8 8.1 9.73E-03 7.64% 2741 10433672 Rrn3 0.4 1.3 9.3 9.73E-03 7.64% 2742 10339596 -1.6 0.3 4.3 9.74E-03 7.64% 2743 10536611 Kcnd2 -0.3 0.8 5.7 9.74E-03 7.64% 2744 10593219 Nnmt 0.6 1.5 11.2 9.75E-03 7.64% 2745 10552440 Zfp719 0.3 1.3 7.5 9.75E-03 7.64% 2746 10552622 2410002F23Rik 0.2 1.2 6.5 9.76E-03 7.64% 2747 10433614 Gm9961 -0.3 0.8 6.3 9.77E-03 7.65% 2748 10341059 -0.9 0.5 5.8 9.77E-03 7.65% 2749 10577237 BB014433 -0.3 0.8 5.1 9.78E-03 7.65% 2750 10514088 Frem1 -0.2 0.9 5.7 9.78E-03 7.65% 2751 10382985 Afmid -0.5 0.7 11.2 9.79E-03 7.66% 2752 10570373 Tfdp1 0.3 1.2 8.8 9.80E-03 7.66% 2753 10507433 Ptch2 -0.2 0.9 6.4 9.81E-03 7.66% 2754 10573110 -0.3 0.8 5.7 9.81E-03 7.66% 2755 10599604 Ccdc160 -0.2 0.9 6.0 9.84E-03 7.67% 2756 10552929 Mtag2 -0.3 0.8 5.2 9.84E-03 7.67% 2757 10529118 Eif2b4 0.5 1.4 8.5 9.84E-03 7.67% 2758 10408684 Tmed10 0.2 1.1 10.8 9.85E-03 7.67% 2759 10392241 Polg2 -0.3 0.8 6.9 9.85E-03 7.67% 2760 10502774 Lphn2 0.3 1.2 8.7 9.85E-03 7.67% 2761 10341880 0.3 1.3 11.8 9.85E-03 7.68% 2762 10572989 Slc10a7 0.3 1.2 8.1 9.86E-03 7.68% 2763 10575255 Pkd1l3 -0.3 0.8 5.8 9.86E-03 7.68% 2764 10404339 -0.3 0.8 6.7 9.88E-03 7.69% 2765 10342132 -0.5 0.7 5.6 9.88E-03 7.69% 2766 10523048 Npffr2 -0.2 0.9 4.8 9.88E-03 7.69% 2767 10458560 Fgf1 -0.6 0.7 9.6 9.90E-03 7.69% 2768 10567335 Gde1 -0.5 0.7 9.4 9.91E-03 7.69% 2769 10415714 Fam123a -0.3 0.8 5.9 9.91E-03 7.69% 2770 10483074 Gcg -0.3 0.8 5.4 9.91E-03 7.69% 2771 10351525 Mpz -0.3 0.8 6.3 9.91E-03 7.69% 2772 10591763 Zfp810 0.3 1.2 7.1 9.92E-03 7.69% 2773 10389894 Abcc3 -0.6 0.7 10.0 9.92E-03 7.69% 2774 10394971 Klf11 -0.3 0.8 7.7 9.92E-03 7.69% 2775 10368675 Marcks 0.6 1.5 8.3 9.93E-03 7.70% 2776 10604143 -0.2 0.9 5.3 9.95E-03 7.70% 2777 10375436 Fam71b -0.3 0.8 5.9 9.95E-03 7.70%

Page 68 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2778 10342306 -0.4 0.8 3.1 9.95E-03 7.70% 2779 10467206 Ppp1r3c 0.7 1.6 8.5 9.96E-03 7.70% 2780 10576696 Insr -0.3 0.8 9.8 9.96E-03 7.70% 2781 10498529 -0.3 0.8 2.7 9.96E-03 7.70% 2782 10340809 0.5 1.4 8.9 9.96E-03 7.70% 2783 10591997 Adamts8 -0.2 0.9 7.6 9.97E-03 7.70% 2784 10555881 Olfr657 -0.3 0.8 4.8 1.00E-02 7.74% 2785 10538413 Znrf2 -0.2 0.9 8.9 1.00E-02 7.74% 2786 10428707 Has2 -0.3 0.8 5.1 1.00E-02 7.75% 2787 10512063 0.3 1.2 7.1 1.00E-02 7.75% 2788 10431051 Scube1 -0.2 0.8 6.5 1.00E-02 7.75% 2789 10580131 Nanos3 -0.2 0.9 6.3 1.01E-02 7.75% 2790 10517005 Gpr3 -0.3 0.8 6.4 1.01E-02 7.75% 2791 10488608 Trib3 -0.4 0.8 6.6 1.01E-02 7.75% 2792 10344244 -0.3 0.8 8.4 1.01E-02 7.75% 2793 10509168 E2f2 0.3 1.2 6.7 1.01E-02 7.76% 2794 10421697 9030625A04Rik 0.4 1.4 8.7 1.01E-02 7.77% 2795 10560797 Vmn1r-ps79 0.4 1.3 4.1 1.01E-02 7.77% 2796 10442191 Vmn1r237 -0.2 0.9 4.1 1.01E-02 7.77% 2797 10474373 Kcna4 -0.3 0.8 4.6 1.01E-02 7.77% 2798 10483667 Cir1 -0.3 0.8 7.1 1.01E-02 7.77% 2799 10339731 -0.4 0.7 11.5 1.01E-02 7.77% 2800 10393642 Eif4a3 0.4 1.3 7.3 1.01E-02 7.78% 2801 10560644 Pvrl2 0.3 1.2 7.8 1.01E-02 7.78% 2802 10338429 -0.4 0.7 7.4 1.01E-02 7.78% 2803 10462587 Stambpl1 0.3 1.2 7.4 1.02E-02 7.79% 2804 10532620 Myo18b -0.4 0.8 9.9 1.02E-02 7.79% 2805 10341003 0.5 1.4 6.7 1.02E-02 7.79% 2806 10413250 Cphx -0.2 0.9 6.0 1.02E-02 7.79% 2807 10392796 Cd300lb 0.3 1.2 6.2 1.02E-02 7.81% 2808 10534960 Gjc3 -0.4 0.8 6.3 1.02E-02 7.81% 2809 10345869 Tmem182 -0.4 0.8 6.0 1.02E-02 7.81% 2810 10601673 Cstf2 0.2 1.1 8.0 1.02E-02 7.81% 2811 10420237 Ube2j2 0.3 1.2 8.2 1.02E-02 7.81% 2812 10383799 Tcn2 0.2 1.1 12.0 1.02E-02 7.82% 2813 10342935 -0.6 0.7 6.1 1.02E-02 7.82% 2814 10339874 -0.4 0.8 9.7 1.02E-02 7.82% 2815 10442311 Ccdc64b -0.2 0.9 6.1 1.02E-02 7.82% 2816 10565437 Tmem135 -0.2 0.9 9.1 1.03E-02 7.83% 2817 10361660 Lats1 0.2 1.1 9.3 1.03E-02 7.83% 2818 10456545 Ccdc68 -0.5 0.7 8.0 1.03E-02 7.83%

Page 69 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2819 10559312 Dhcr7 -0.4 0.8 10.0 1.03E-02 7.83% 2820 10503334 Gem 0.3 1.2 6.5 1.03E-02 7.83% 2821 10587534 Bckdhb -0.2 0.9 11.6 1.03E-02 7.83% 2822 10598562 B630019K06Rik -0.2 0.9 6.5 1.03E-02 7.83% 2823 10514275 Ptplad2 0.3 1.2 6.0 1.03E-02 7.83% 2824 10546631 Frmd4b -0.4 0.8 9.5 1.03E-02 7.83% 2825 10434233 Ufd1l 0.2 1.1 9.1 1.03E-02 7.83% 2826 10338347 0.3 1.3 8.8 1.03E-02 7.83% 2827 10585586 Ube2s 0.2 1.2 8.0 1.03E-02 7.83% 2828 10386416 Olfr222 -0.3 0.8 6.2 1.03E-02 7.83% 2829 10340830 0.9 1.8 3.8 1.03E-02 7.83% 2830 10526848 A430033K04Rik -0.3 0.8 7.3 1.03E-02 7.83% 2831 10343128 0.6 1.5 6.8 1.03E-02 7.83% 2832 10496605 Ccbl2 0.2 1.2 11.8 1.03E-02 7.83% 2833 10498919 -0.2 0.8 4.3 1.03E-02 7.83% 2834 10545576 Mrpl19 0.2 1.2 8.1 1.03E-02 7.83% 2835 10601922 -0.2 0.8 6.9 1.04E-02 7.83% 2836 10425370 Cacna1i -0.2 0.9 5.8 1.04E-02 7.83% 2837 10577421 Gm14851 -0.4 0.8 6.9 1.04E-02 7.83% 2838 10338191 -0.4 0.7 6.7 1.04E-02 7.83% 2839 10601314 Tsx -0.2 0.9 6.0 1.04E-02 7.83% 2840 10339137 -0.8 0.6 3.5 1.04E-02 7.83% 2841 10565393 Olfr304 -0.3 0.8 3.5 1.04E-02 7.83% 2842 10343016 -0.3 0.8 7.9 1.04E-02 7.83% 2843 10352119 Pppde1 0.4 1.3 8.5 1.04E-02 7.83% 2844 10468639 Dclre1a -0.3 0.8 8.3 1.04E-02 7.83% 2845 10343751 0.9 1.9 4.2 1.04E-02 7.83% 2846 10464153 Nhlrc2 -0.3 0.8 8.6 1.04E-02 7.83% 2847 10502745 Rpl11 0.2 1.1 10.1 1.04E-02 7.83% 2848 10555256 -0.2 0.9 7.1 1.04E-02 7.83% 2849 10476900 Cstl1 -0.3 0.8 5.3 1.04E-02 7.83% 2850 10341531 0.3 1.3 9.9 1.05E-02 7.83% 2851 10556039 Olfr17 -0.3 0.8 4.6 1.05E-02 7.83% 2852 10600698 5430427O19Rik 0.4 1.3 4.9 1.05E-02 7.83% 2853 10482139 Pdcl 0.3 1.2 8.7 1.05E-02 7.83% 2854 10468448 -0.3 0.8 7.3 1.05E-02 7.83% 2855 10380712 Prr15l -0.2 0.9 6.3 1.05E-02 7.83% 2856 10353689 Phf3 -0.2 0.9 9.5 1.05E-02 7.83% 2857 10564027 0.3 1.3 3.2 1.05E-02 7.83% 2858 10564077 0.3 1.3 3.2 1.05E-02 7.83% 2859 10564079 0.3 1.3 3.2 1.05E-02 7.83%

Page 70 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2860 10564085 0.3 1.3 3.2 1.05E-02 7.83% 2861 10564087 0.3 1.3 3.2 1.05E-02 7.83% 2862 10564091 0.3 1.3 3.2 1.05E-02 7.83% 2863 10564093 0.3 1.3 3.2 1.05E-02 7.83% 2864 10564095 0.3 1.3 3.2 1.05E-02 7.83% 2865 10564097 0.3 1.3 3.2 1.05E-02 7.83% 2866 10564099 0.3 1.3 3.2 1.05E-02 7.83% 2867 10564101 0.3 1.3 3.2 1.05E-02 7.83% 2868 10564103 0.3 1.3 3.2 1.05E-02 7.83% 2869 10564105 0.3 1.3 3.2 1.05E-02 7.83% 2870 10564107 0.3 1.3 3.2 1.05E-02 7.83% 2871 10564113 0.3 1.3 3.2 1.05E-02 7.83% 2872 10564115 0.3 1.3 3.2 1.05E-02 7.83% 2873 10564119 0.3 1.3 3.2 1.05E-02 7.83% 2874 10564121 0.3 1.3 3.2 1.05E-02 7.83% 2875 10564123 0.3 1.3 3.2 1.05E-02 7.83% 2876 10564125 0.3 1.3 3.2 1.05E-02 7.83% 2877 10564127 0.3 1.3 3.2 1.05E-02 7.83% 2878 10564129 0.3 1.3 3.2 1.05E-02 7.83% 2879 10564139 0.3 1.3 3.2 1.05E-02 7.83% 2880 10428008 Ankrd33b -0.3 0.8 6.2 1.05E-02 7.83% 2881 10599595 -0.2 0.9 5.3 1.05E-02 7.83% 2882 10423520 Sema5a -0.2 0.9 5.8 1.05E-02 7.84% 2883 10570711 Defa20 -0.3 0.8 6.7 1.05E-02 7.84% 2884 10470696 Med27 0.4 1.3 8.0 1.05E-02 7.85% 2885 10457598 Ss18 0.2 1.2 7.9 1.05E-02 7.85% 2886 10436095 Retnla -0.9 0.5 4.3 1.05E-02 7.85% 2887 10608692 Rn4.5s 0.3 1.3 10.7 1.05E-02 7.86% 2888 10341010 0.4 1.3 9.7 1.05E-02 7.86% 2889 10526514 Cldn15 -0.3 0.8 6.2 1.06E-02 7.86% 2890 10338718 -0.5 0.7 5.4 1.06E-02 7.86% 2891 10532744 Selplg 0.2 1.2 6.9 1.06E-02 7.86% 2892 10590383 Deb1 0.3 1.2 7.7 1.06E-02 7.86% 2893 10342233 -0.4 0.7 6.6 1.06E-02 7.86% 2894 10366581 0.3 1.2 8.1 1.06E-02 7.86% 2895 10372726 0.3 1.2 8.1 1.06E-02 7.86% 2896 10595633 Bcl2a1d 0.3 1.2 6.3 1.06E-02 7.87% 2897 10387791 Slc16a13 0.3 1.2 7.4 1.06E-02 7.87% 2898 10343043 0.7 1.7 4.3 1.06E-02 7.87% 2899 10338456 -0.4 0.7 6.0 1.06E-02 7.87% 2900 10590494 Kif15 0.6 1.5 5.8 1.06E-02 7.87%

Page 71 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2901 10338292 -0.4 0.8 10.3 1.06E-02 7.87% 2902 10477233 Xkr7 -0.2 0.9 6.6 1.06E-02 7.87% 2903 10502770 Lphn2 0.6 1.5 6.2 1.06E-02 7.88% 2904 10343072 0.5 1.4 4.1 1.06E-02 7.88% 2905 10420338 Pspc1 0.2 1.2 8.2 1.06E-02 7.88% 2906 10341285 0.6 1.5 6.3 1.06E-02 7.88% 2907 10529544 -0.3 0.8 5.5 1.06E-02 7.88% 2908 10464445 0.4 1.3 9.5 1.07E-02 7.88% 2909 10554967 -0.2 0.8 5.1 1.07E-02 7.88% 2910 10403577 -0.2 0.8 7.0 1.07E-02 7.88% 2911 10461152 Snhg1 0.5 1.4 5.6 1.07E-02 7.88% 2912 10595622 0.6 1.6 7.7 1.07E-02 7.88% 2913 10595636 0.6 1.6 7.7 1.07E-02 7.88% 2914 10540544 Thumpd3 0.3 1.2 7.9 1.07E-02 7.88% 2915 10514255 Mllt3 0.3 1.2 7.5 1.07E-02 7.88% 2916 10344422 0.2 1.2 9.1 1.07E-02 7.88% 2917 10574027 Mt1 0.7 1.7 12.4 1.07E-02 7.88% 2918 10342549 -0.4 0.8 6.3 1.07E-02 7.88% 2919 10471904 Arpc5l 0.3 1.2 7.3 1.07E-02 7.88% 2920 10477237 BC020535 -0.2 0.9 6.7 1.07E-02 7.88% 2921 10363137 Nus1 0.3 1.2 10.3 1.07E-02 7.89% 2922 10419323 Dlgap5 0.5 1.5 6.3 1.07E-02 7.89% 2923 10341916 -0.8 0.6 4.5 1.07E-02 7.89% 2924 10340587 -0.3 0.8 7.1 1.07E-02 7.89% 2925 10587873 0.2 1.2 4.7 1.07E-02 7.89% 2926 10447415 -0.2 0.8 7.5 1.07E-02 7.89% 2927 10347188 Vwc2l -0.2 0.9 5.2 1.07E-02 7.89% 2928 10377368 Rpl26 0.3 1.2 8.6 1.07E-02 7.89% 2929 10437778 Parn 0.2 1.2 8.0 1.07E-02 7.89% 2930 10416503 Snora31 0.4 1.3 6.8 1.07E-02 7.89% 2931 10388880 Tmem97 0.3 1.2 10.7 1.08E-02 7.89% 2932 10344062 0.3 1.3 10.8 1.08E-02 7.89% 2933 10473874 Arfgap2 0.2 1.1 11.0 1.08E-02 7.90% 2934 10510908 -0.3 0.8 7.5 1.08E-02 7.91% 2935 10425421 Fam83f -0.2 0.8 5.6 1.08E-02 7.91% 2936 10424804 Exosc4 0.2 1.1 7.5 1.08E-02 7.94% 2937 10604380 Zdhhc9 -0.2 0.9 10.9 1.09E-02 7.95% 2938 10426242 Chkb -0.2 0.9 6.9 1.09E-02 7.95% 2939 10351491 Olfml2b -0.2 0.9 6.0 1.09E-02 7.95% 2940 10417972 Camk2g 0.3 1.2 7.5 1.09E-02 7.96% 2941 10553403 Htatip2 0.2 1.2 7.7 1.09E-02 7.96%

Page 72 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2942 10445774 B430306N03Rik 0.3 1.2 7.0 1.09E-02 7.96% 2943 10587854 Slc9a9 0.2 1.2 7.6 1.09E-02 7.97% 2944 10582580 0.8 1.8 10.0 1.09E-02 7.97% 2945 10569370 Th -0.2 0.8 6.3 1.09E-02 7.98% 2946 10518585 Kif1b -0.3 0.8 9.3 1.09E-02 7.98% 2947 10425016 Commd5 0.2 1.2 8.1 1.09E-02 7.98% 2948 10525397 Arpc3 0.2 1.1 8.8 1.09E-02 7.98% 2949 10487392 Kcnip3 -0.2 0.9 6.3 1.09E-02 7.98% 2950 10344334 -0.5 0.7 8.7 1.09E-02 7.98% 2951 10340870 0.4 1.3 7.8 1.10E-02 7.98% 2952 10338575 0.7 1.7 4.5 1.10E-02 7.99% 2953 10396699 Fntb 0.2 1.2 6.3 1.10E-02 7.99% 2954 10582582 1.1 2.2 8.1 1.10E-02 7.99% 2955 10582584 1.1 2.2 8.1 1.10E-02 7.99% 2956 10503989 0.2 1.1 7.9 1.11E-02 8.04% 2957 10485429 Pdhx 0.3 1.2 8.0 1.11E-02 8.04% 2958 10544779 Hoxa7 -0.2 0.8 6.2 1.11E-02 8.05% 2959 10423078 Gm10389 -0.2 0.9 4.2 1.11E-02 8.05% 2960 10450640 Mrps18b 0.3 1.2 9.9 1.11E-02 8.05% 2961 10359446 AI848100 0.3 1.2 7.9 1.11E-02 8.05% 2962 10405885 -0.5 0.7 3.2 1.11E-02 8.06% 2963 10528340 Dnajc2 0.2 1.2 7.5 1.11E-02 8.06% 2964 10375439 Med7 0.4 1.3 8.3 1.11E-02 8.06% 2965 10432473 Nckap5l -0.2 0.9 7.2 1.11E-02 8.06% 2966 10340192 0.6 1.5 5.5 1.11E-02 8.06% 2967 10505071 Tmem38b 0.3 1.2 6.3 1.11E-02 8.06% 2968 10397158 Acot3 0.6 1.5 10.2 1.11E-02 8.06% 2969 10351679 Cd84 0.3 1.2 6.5 1.11E-02 8.06% 2970 10450614 2310061I04Rik -0.2 0.9 8.0 1.11E-02 8.06% 2971 10505438 Orm1 0.2 1.1 13.1 1.11E-02 8.06% 2972 10551347 Blvrb -0.3 0.8 10.4 1.11E-02 8.06% 2973 10374060 Ankrd36 -0.2 0.8 5.2 1.12E-02 8.07% 2974 10604897 0.2 1.2 3.0 1.12E-02 8.07% 2975 10552725 Vrk3 0.2 1.1 8.3 1.12E-02 8.07% 2976 10354588 Stk17b 0.4 1.3 7.9 1.12E-02 8.07% 2977 10387757 Rai12 0.2 1.1 8.9 1.12E-02 8.07% 2978 10434668 Tmem97 0.3 1.2 12.0 1.12E-02 8.07% 2979 10414460 Naa30 0.2 1.2 7.5 1.12E-02 8.07% 2980 10512709 Mcart1 -0.3 0.8 9.5 1.12E-02 8.08% 2981 10604850 -0.3 0.8 6.0 1.12E-02 8.09% 2982 10414711 -0.4 0.8 3.5 1.12E-02 8.09%

Page 73 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

2983 10494757 -0.3 0.8 6.5 1.12E-02 8.09% 2984 10484190 -0.3 0.8 5.1 1.12E-02 8.09% 2985 10508986 Stmn1 0.9 1.9 8.5 1.12E-02 8.09% 2986 10578138 Dctn6 0.3 1.2 9.8 1.12E-02 8.09% 2987 10403716 AW209491 0.3 1.2 7.5 1.12E-02 8.09% 2988 10352393 Srp9 0.4 1.3 8.2 1.12E-02 8.09% 2989 10505537 Gm428 -0.2 0.9 5.2 1.12E-02 8.09% 2990 10505550 Gm428 -0.2 0.9 5.2 1.12E-02 8.09% 2991 10355264 0.3 1.2 6.5 1.13E-02 8.10% 2992 10389973 Spata20 -0.2 0.8 5.9 1.13E-02 8.10% 2993 10546805 Ddx18 0.2 1.2 8.5 1.13E-02 8.10% 2994 10446063 Tnfaip8l1 -0.3 0.8 6.8 1.13E-02 8.10% 2995 10344112 -0.7 0.6 5.0 1.13E-02 8.10% 2996 10504609 -0.2 0.9 7.2 1.13E-02 8.11% 2997 10600718 Sec61g 0.2 1.2 9.5 1.13E-02 8.11% 2998 10342212 -0.5 0.7 5.9 1.13E-02 8.11% 2999 10364511 9130017N09Rik -0.2 0.9 5.8 1.13E-02 8.11% 3000 10457409 Usp14 0.2 1.2 9.7 1.13E-02 8.11% 3001 10518201 Pramef12 -0.3 0.8 4.6 1.13E-02 8.11% 3002 10509280 Hspg2 -0.2 0.9 7.8 1.13E-02 8.11% 3003 10344012 -0.4 0.8 9.6 1.13E-02 8.11% 3004 10548176 5930416I19Rik 0.2 1.2 7.5 1.13E-02 8.11% 3005 10391555 Ppy -0.3 0.8 7.0 1.13E-02 8.11% 3006 10339438 -0.4 0.8 7.0 1.13E-02 8.11% 3007 10374350 -0.2 0.9 6.7 1.13E-02 8.11% 3008 10587829 Plod2 -0.3 0.8 4.4 1.13E-02 8.11% 3009 10523111 0.4 1.4 11.0 1.14E-02 8.12% 3010 10344555 -0.6 0.6 4.2 1.14E-02 8.12% 3011 10569296 Krtap5-2 -0.3 0.8 7.8 1.14E-02 8.12% 3012 10350136 Csrp1 0.4 1.3 8.7 1.14E-02 8.13% 3013 10353707 Ptp4a1 -0.3 0.8 11.6 1.14E-02 8.13% 3014 10544837 Tril -0.2 0.8 5.8 1.14E-02 8.13% 3015 10557165 2010110P09Rik 0.3 1.3 7.1 1.14E-02 8.15% 3016 10462096 -0.2 0.8 5.1 1.14E-02 8.15% 3017 10498018 Pcdh18 0.3 1.2 6.3 1.14E-02 8.15% 3018 10478776 Arfgef2 0.2 1.2 8.2 1.14E-02 8.15% 3019 10423575 0.3 1.2 3.8 1.14E-02 8.15% 3020 10356339 Pde6d 0.3 1.2 9.0 1.15E-02 8.16% 3021 10385447 Dppa1 0.3 1.2 3.9 1.15E-02 8.16% 3022 10373873 Sf3a1 0.3 1.2 7.8 1.15E-02 8.17% 3023 10380285 Tmem100 -0.4 0.8 4.8 1.15E-02 8.17%

Page 74 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3024 10528177 Speer4e 0.2 1.2 3.7 1.15E-02 8.17% 3025 10366767 Ctdsp2 -0.3 0.8 7.7 1.15E-02 8.17% 3026 10485340 Itpa 0.3 1.2 8.7 1.15E-02 8.17% 3027 10564089 0.4 1.3 3.2 1.15E-02 8.17% 3028 10469575 Gm13363 -0.3 0.8 11.5 1.15E-02 8.17% 3029 10434007 Aifm3 -0.2 0.9 6.0 1.15E-02 8.19% 3030 10344597 0.4 1.3 10.0 1.15E-02 8.19% 3031 10408249 -0.4 0.8 7.0 1.15E-02 8.19% 3032 10404783 Edn1 -0.3 0.8 6.2 1.15E-02 8.19% 3033 10395158 -0.2 0.9 5.6 1.15E-02 8.19% 3034 10389680 Msi2 -0.2 0.9 8.2 1.16E-02 8.22% 3035 10431749 Adamts20 -0.2 0.8 5.3 1.16E-02 8.22% 3036 10399376 -0.3 0.8 6.0 1.16E-02 8.22% 3037 10526232 Wbscr27 -0.3 0.8 7.4 1.16E-02 8.22% 3038 10390454 E130012A19Rik -0.2 0.9 7.1 1.16E-02 8.23% 3039 10580635 Ces1d -0.3 0.8 12.5 1.16E-02 8.23% 3040 10518113 9030409G11Rik -0.2 0.9 6.3 1.16E-02 8.24% 3041 10598073 0.6 1.5 11.5 1.17E-02 8.24% 3042 10345902 -0.2 0.9 5.4 1.17E-02 8.24% 3043 10594460 Dis3l 0.2 1.2 7.6 1.17E-02 8.24% 3044 10598644 Gm14483 -0.2 0.9 5.9 1.17E-02 8.26% 3045 10339103 -0.4 0.8 9.3 1.17E-02 8.26% 3046 10419156 Ear10 0.3 1.2 4.9 1.17E-02 8.26% 3047 10363118 Dcbld1 0.2 1.2 7.2 1.17E-02 8.26% 3048 10340152 -0.3 0.8 8.9 1.17E-02 8.26% 3049 10481147 Surf4 0.2 1.1 11.6 1.17E-02 8.27% 3050 10500529 Phgdh -0.3 0.8 6.4 1.17E-02 8.28% 3051 10356470 Glrp1 -0.2 0.9 4.6 1.17E-02 8.28% 3052 10580100 Cc2d1a 0.2 1.2 7.1 1.18E-02 8.28% 3053 10539441 B230319C09Rik -0.3 0.8 7.0 1.18E-02 8.28% 3054 10413238 Cphx -0.2 0.9 5.9 1.18E-02 8.29% 3055 10413260 Cphx -0.2 0.9 5.9 1.18E-02 8.29% 3056 10598656 Gm14483 -0.2 0.9 5.9 1.18E-02 8.29% 3057 10598658 Gm14483 -0.2 0.9 5.9 1.18E-02 8.29% 3058 10598660 Gm14483 -0.2 0.9 5.9 1.18E-02 8.29% 3059 10449672 Tmprss3 -0.3 0.8 6.1 1.18E-02 8.29% 3060 10505888 Ifna5 -0.3 0.8 7.2 1.18E-02 8.29% 3061 10543802 Plxna4 -0.2 0.8 7.0 1.18E-02 8.29% 3062 10444439 Atf6b 0.3 1.3 8.1 1.18E-02 8.29% 3063 10440284 4930453N24Rik 0.4 1.3 8.1 1.18E-02 8.29% 3064 10536898 Irf5 0.4 1.3 7.9 1.18E-02 8.29%

Page 75 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3065 10394625 Nbas 0.3 1.2 8.2 1.18E-02 8.29% 3066 10552353 -0.3 0.8 6.5 1.18E-02 8.29% 3067 10357630 Srgap2 0.3 1.2 8.1 1.18E-02 8.29% 3068 10345141 Lmbrd1 -0.2 0.9 9.4 1.18E-02 8.30% 3069 10586844 Adam10 0.3 1.2 8.9 1.19E-02 8.31% 3070 10340769 0.2 1.1 11.2 1.19E-02 8.31% 3071 10603936 Gm5168 0.4 1.3 4.2 1.19E-02 8.31% 3072 10606728 -0.2 0.9 5.9 1.19E-02 8.31% 3073 10394344 Gm6682 0.3 1.2 10.7 1.19E-02 8.31% 3074 10578989 Psd3 -0.3 0.8 9.3 1.19E-02 8.32% 3075 10527965 Cldn12 -0.2 0.9 9.6 1.19E-02 8.35% 3076 10497912 Gm5148 0.3 1.2 5.8 1.19E-02 8.35% 3077 10343142 -0.7 0.6 5.5 1.19E-02 8.35% 3078 10550320 0.6 1.6 7.2 1.20E-02 8.37% 3079 10493664 Nup210l -0.3 0.8 5.2 1.20E-02 8.37% 3080 10421709 Enox1 -0.2 0.8 6.1 1.20E-02 8.37% 3081 10357137 Gli2 -0.2 0.9 5.8 1.20E-02 8.37% 3082 10404612 Rreb1 0.2 1.1 8.7 1.20E-02 8.39% 3083 10465838 Mta2 -0.2 0.9 6.9 1.20E-02 8.39% 3084 10405935 Rplp0 0.2 1.1 12.1 1.20E-02 8.39% 3085 10341793 0.4 1.3 8.3 1.20E-02 8.39% 3086 10338708 0.3 1.3 8.9 1.20E-02 8.39% 3087 10498771 Pdcd10 0.3 1.2 7.0 1.20E-02 8.39% 3088 10431656 Rpl31 0.2 1.2 10.5 1.20E-02 8.39% 3089 10460787 Atg2a -0.3 0.8 8.2 1.20E-02 8.39% 3090 10403842 Elmo1 0.2 1.2 6.3 1.20E-02 8.39% 3091 10579958 Il15 0.4 1.3 6.5 1.21E-02 8.40% 3092 10395155 Fam110c -0.2 0.9 5.7 1.21E-02 8.41% 3093 10381653 Ccdc103 -0.2 0.9 5.1 1.21E-02 8.41% 3094 10400894 Gpr135 -0.2 0.9 7.2 1.21E-02 8.41% 3095 10381588 Grn 0.2 1.2 11.2 1.21E-02 8.41% 3096 10351039 Gas5 0.8 1.8 5.2 1.21E-02 8.41% 3097 10415572 -0.2 0.9 6.6 1.21E-02 8.41% 3098 10457407 -0.3 0.8 7.8 1.21E-02 8.42% 3099 10404061 Hist1h2bb 0.7 1.7 7.3 1.21E-02 8.43% 3100 10590648 Top2a 0.3 1.2 3.2 1.21E-02 8.43% 3101 10384322 Hus1 0.3 1.2 8.5 1.22E-02 8.43% 3102 10424979 Gpt -0.4 0.8 9.4 1.22E-02 8.43% 3103 10431601 Arsa -0.3 0.8 6.7 1.22E-02 8.43% 3104 10410984 Ckmt2 -0.7 0.6 5.3 1.22E-02 8.43% 3105 10463632 Tmem180 -0.2 0.9 7.1 1.22E-02 8.43%

Page 76 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3106 10601973 0.2 1.2 3.8 1.22E-02 8.43% 3107 10344055 -0.2 0.8 10.5 1.22E-02 8.44% 3108 10385504 Gm5431 0.5 1.4 5.3 1.22E-02 8.44% 3109 10559406 Tfpt 0.3 1.2 8.6 1.22E-02 8.44% 3110 10362434 Trdn -0.7 0.6 6.3 1.22E-02 8.45% 3111 10405488 Tmed9 0.4 1.3 8.0 1.22E-02 8.45% 3112 10426467 Tmem117 -0.2 0.8 5.7 1.22E-02 8.46% 3113 10596815 Rnf123 -0.2 0.9 8.8 1.22E-02 8.46% 3114 10586433 Rbpms2 -0.2 0.9 8.6 1.22E-02 8.46% 3115 10369647 Ddx50 0.3 1.2 8.4 1.23E-02 8.46% 3116 10600144 F8a 0.2 1.1 6.7 1.23E-02 8.46% 3117 10338856 0.6 1.5 5.9 1.23E-02 8.46% 3118 10449018 Haghl -0.2 0.9 6.8 1.23E-02 8.46% 3119 10510391 Srm 0.4 1.3 10.4 1.23E-02 8.46% 3120 10342572 -0.2 0.9 12.0 1.23E-02 8.47% 3121 10561335 Prkcz 0.3 1.2 7.7 1.23E-02 8.47% 3122 10469140 -0.2 0.8 5.4 1.23E-02 8.47% 3123 10425522 Rbx1 0.2 1.1 8.4 1.23E-02 8.47% 3124 10394682 -0.3 0.8 7.5 1.23E-02 8.47% 3125 10529923 Lcorl 0.2 1.2 7.5 1.23E-02 8.47% 3126 10592870 Foxr1 -0.2 0.9 5.0 1.23E-02 8.47% 3127 10476197 Itpa 0.2 1.2 8.5 1.23E-02 8.47% 3128 10348277 Atg16l1 0.2 1.1 8.4 1.23E-02 8.48% 3129 10493086 Hdgf -0.2 0.8 9.7 1.23E-02 8.48% 3130 10427881 -0.4 0.8 5.5 1.23E-02 8.48% 3131 10423599 Matn2 -0.2 0.9 5.6 1.24E-02 8.48% 3132 10588495 Dusp7 0.2 1.1 8.7 1.24E-02 8.49% 3133 10353684 0.2 1.2 3.2 1.24E-02 8.49% 3134 10338129 0.3 1.2 8.0 1.24E-02 8.49% 3135 10554599 -0.3 0.8 4.8 1.24E-02 8.50% 3136 10575473 Gm9558 0.2 1.2 4.8 1.24E-02 8.50% 3137 10525731 -0.4 0.8 5.9 1.24E-02 8.50% 3138 10442887 Fbxl16 -0.3 0.8 5.5 1.24E-02 8.50% 3139 10339630 0.5 1.5 7.8 1.24E-02 8.50% 3140 10549730 Nat14 -0.2 0.9 6.4 1.24E-02 8.50% 3141 10459158 0.2 1.1 7.4 1.24E-02 8.50% 3142 10559241 Igf2as -0.3 0.8 6.8 1.24E-02 8.50% 3143 10340899 0.9 1.9 7.8 1.24E-02 8.50% 3144 10393793 Pde6g -0.2 0.9 6.4 1.24E-02 8.50% 3145 10445710 Frs3 -0.2 0.9 7.5 1.24E-02 8.50% 3146 10363372 Pla2g12b 0.3 1.2 10.0 1.24E-02 8.50%

Page 77 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3147 10550778 Vmn1r132 0.2 1.2 4.3 1.25E-02 8.51% 3148 10560767 Vmn1r132 0.2 1.2 4.3 1.25E-02 8.51% 3149 10415960 Ints9 0.2 1.1 8.7 1.25E-02 8.51% 3150 10572724 Zfp709 0.3 1.3 4.8 1.25E-02 8.51% 3151 10516079 Oxct2b -0.3 0.8 7.1 1.25E-02 8.51% 3152 10408677 Lyrm4 -0.2 0.9 9.3 1.25E-02 8.52% 3153 10339600 0.5 1.4 4.4 1.25E-02 8.52% 3154 10513818 Stmn1 0.9 1.9 8.3 1.25E-02 8.53% 3155 10489646 Slc35c2 0.3 1.2 8.7 1.25E-02 8.54% 3156 10395739 Srp54b 0.3 1.2 11.2 1.25E-02 8.54% 3157 10344569 0.4 1.3 6.9 1.25E-02 8.54% 3158 10456814 Pias2 -0.2 0.9 9.0 1.26E-02 8.54% 3159 10405994 Med10 0.2 1.2 8.6 1.26E-02 8.54% 3160 10579442 Slc5a5 -0.2 0.9 6.2 1.26E-02 8.54% 3161 10451451 Gnmt -0.3 0.8 12.4 1.26E-02 8.54% 3162 10559175 Krtap5-4 -0.3 0.8 7.4 1.26E-02 8.54% 3163 10386775 Prpsap2 0.2 1.1 8.4 1.26E-02 8.54% 3164 10484457 0.6 1.5 7.9 1.26E-02 8.54% 3165 10385375 Thg1l 0.3 1.2 6.9 1.26E-02 8.54% 3166 10591628 Dock6 -0.2 0.9 7.7 1.26E-02 8.54% 3167 10453318 Abcg5 -0.4 0.7 10.7 1.26E-02 8.54% 3168 10342815 -0.6 0.6 5.8 1.26E-02 8.54% 3169 10344256 -1.2 0.4 3.4 1.26E-02 8.54% 3170 10482712 Stam2 0.2 1.1 8.4 1.26E-02 8.54% 3171 10339689 -0.5 0.7 7.1 1.26E-02 8.55% 3172 10479749 Rpp38 0.6 1.5 9.4 1.26E-02 8.55% 3173 10415293 Rnf31 0.2 1.1 7.8 1.26E-02 8.55% 3174 10469457 Plxdc2 -0.3 0.8 6.2 1.26E-02 8.55% 3175 10569152 Pddc1 0.3 1.2 8.9 1.26E-02 8.55% 3176 10442638 Mrps34 0.2 1.2 7.8 1.26E-02 8.55% 3177 10341345 -0.4 0.7 6.5 1.26E-02 8.55% 3178 10526098 Scand3 -0.4 0.8 6.8 1.26E-02 8.55% 3179 10419284 -0.4 0.7 4.8 1.26E-02 8.55% 3180 10550824 Vmn1r180 0.2 1.2 3.0 1.27E-02 8.56% 3181 10457040 Zfp516 0.2 1.2 6.9 1.27E-02 8.56% 3182 10340858 0.2 1.2 10.8 1.27E-02 8.56% 3183 10485782 0.2 1.2 3.6 1.27E-02 8.56% 3184 10570119 Carkd -0.2 0.9 8.9 1.27E-02 8.56% 3185 10439991 Tfg 0.4 1.3 10.7 1.27E-02 8.56% 3186 10341273 0.3 1.3 8.8 1.27E-02 8.56% 3187 10504905 E130309F12Rik 0.4 1.3 6.9 1.27E-02 8.57%

Page 78 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3188 10344477 0.7 1.6 4.4 1.27E-02 8.57% 3189 10338647 0.5 1.4 5.1 1.27E-02 8.57% 3190 10405234 Snrpd2 0.2 1.2 8.0 1.27E-02 8.57% 3191 10551173 Exosc5 -0.2 0.9 8.1 1.27E-02 8.57% 3192 10531529 Cnot6l -0.2 0.9 9.7 1.27E-02 8.57% 3193 10428796 Fbxo32 -0.3 0.8 6.3 1.27E-02 8.57% 3194 10341291 -0.7 0.6 3.1 1.27E-02 8.57% 3195 10356593 Hes6 0.5 1.5 9.6 1.27E-02 8.58% 3196 10338487 -0.4 0.8 7.9 1.28E-02 8.58% 3197 10341326 0.6 1.5 7.1 1.28E-02 8.59% 3198 10342867 -0.5 0.7 5.9 1.28E-02 8.59% 3199 10340706 -0.4 0.8 8.3 1.28E-02 8.60% 3200 10356764 2310007B03Rik -0.2 0.9 5.8 1.28E-02 8.60% 3201 10491038 Tbl1xr1 -0.4 0.8 9.0 1.28E-02 8.60% 3202 10341331 -0.8 0.6 4.4 1.28E-02 8.60% 3203 10541494 Rps27a 0.2 1.1 8.8 1.28E-02 8.60% 3204 10512901 Mrpl50 0.2 1.2 9.8 1.28E-02 8.60% 3205 10608676 L2hgdh -0.3 0.8 8.3 1.28E-02 8.60% 3206 10402766 Akt1 0.3 1.3 9.9 1.28E-02 8.60% 3207 10498576 Lxn 0.3 1.2 5.5 1.28E-02 8.60% 3208 10470320 0.4 1.3 6.6 1.28E-02 8.60% 3209 10352576 Esrrg -0.4 0.8 7.3 1.28E-02 8.60% 3210 10447891 Acat2 -0.2 0.8 9.8 1.28E-02 8.60% 3211 10467489 Ptp4a1 -0.3 0.8 11.6 1.28E-02 8.60% 3212 10519659 0.3 1.2 8.1 1.28E-02 8.60% 3213 10392484 Abca8b -0.3 0.8 8.6 1.28E-02 8.60% 3214 10571248 -0.3 0.8 6.9 1.28E-02 8.60% 3215 10573048 Anapc10 0.3 1.2 7.4 1.28E-02 8.60% 3216 10341554 0.5 1.4 6.0 1.29E-02 8.60% 3217 10459153 Cdx1 -0.3 0.8 7.2 1.29E-02 8.60% 3218 10456721 0.7 1.6 8.0 1.29E-02 8.60% 3219 10375307 C1qtnf2 -0.2 0.9 6.1 1.29E-02 8.60% 3220 10435697 Popdc2 -0.2 0.8 5.5 1.29E-02 8.60% 3221 10491062 Rpl27a 0.2 1.1 10.8 1.29E-02 8.60% 3222 10393222 Srp68 0.3 1.2 9.3 1.29E-02 8.60% 3223 10375014 4930524B15Rik -0.2 0.8 5.3 1.29E-02 8.61% 3224 10348456 Cops8 0.2 1.1 8.7 1.29E-02 8.61% 3225 10459510 Mir694 -0.3 0.8 6.4 1.29E-02 8.61% 3226 10380896 Erbb2 -0.2 0.8 6.6 1.29E-02 8.61% 3227 10342618 -0.5 0.7 8.5 1.29E-02 8.61% 3228 10341810 0.4 1.4 5.5 1.29E-02 8.61%

Page 79 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3229 10515431 Kif2c 0.5 1.4 5.8 1.29E-02 8.61% 3230 10583898 -0.2 0.9 6.8 1.29E-02 8.61% 3231 10341668 0.4 1.4 5.8 1.29E-02 8.61% 3232 10546056 Rab43 -0.3 0.8 9.7 1.29E-02 8.61% 3233 10548978 Slco1a1 -0.2 0.9 12.4 1.30E-02 8.62% 3234 10587262 Klhl31 -0.4 0.8 4.8 1.30E-02 8.62% 3235 10536818 Calu 0.3 1.2 10.1 1.30E-02 8.62% 3236 10441003 Runx1 0.3 1.2 6.2 1.30E-02 8.63% 3237 10340679 0.5 1.4 5.2 1.30E-02 8.63% 3238 10496569 Gbp6 0.3 1.3 8.5 1.30E-02 8.63% 3239 10574023 Mt2 0.5 1.4 13.1 1.30E-02 8.63% 3240 10367931 Ltv1 0.4 1.3 8.2 1.30E-02 8.63% 3241 10357944 Ppp1r12b -0.2 0.8 7.8 1.30E-02 8.63% 3242 10344078 -0.5 0.7 7.8 1.30E-02 8.63% 3243 10577434 Gm7849 -0.4 0.7 6.6 1.30E-02 8.63% 3244 10341176 -0.5 0.7 6.4 1.30E-02 8.64% 3245 10555510 Pde2a -0.3 0.8 8.2 1.30E-02 8.64% 3246 10389590 Gdpd1 0.5 1.4 7.8 1.30E-02 8.64% 3247 10460573 Eif1ad 0.2 1.2 8.2 1.30E-02 8.64% 3248 10517948 Spen -0.2 0.9 8.4 1.31E-02 8.65% 3249 10382438 Cd300a 0.1 1.1 7.1 1.31E-02 8.65% 3250 10598507 Slc38a5 -0.2 0.9 6.0 1.31E-02 8.65% 3251 10342243 0.4 1.3 6.8 1.31E-02 8.66% 3252 10355536 Tns1 -0.3 0.8 10.2 1.31E-02 8.66% 3253 10401166 Pigh 0.2 1.2 6.8 1.31E-02 8.66% 3254 10392374 Cacng5 -0.3 0.8 5.9 1.31E-02 8.66% 3255 10595836 E030011O05Rik -0.2 0.9 5.8 1.31E-02 8.66% 3256 10460706 Syvn1 0.5 1.4 9.7 1.31E-02 8.66% 3257 10461214 Tmem223 -0.2 0.8 9.7 1.31E-02 8.66% 3258 10506767 Echdc2 -0.2 0.9 11.0 1.31E-02 8.66% 3259 10341152 0.8 1.7 5.3 1.31E-02 8.66% 3260 10515090 Cdkn2c 0.4 1.3 7.7 1.31E-02 8.66% 3261 10542738 0.3 1.2 9.3 1.32E-02 8.68% 3262 10479726 Pcmtd2 -0.3 0.8 9.3 1.32E-02 8.68% 3263 10400562 0.2 1.2 4.7 1.32E-02 8.69% 3264 10515536 Ipo13 0.3 1.2 8.0 1.32E-02 8.69% 3265 10600341 Emd 0.3 1.2 8.9 1.32E-02 8.69% 3266 10347508 Fam134a -0.2 0.9 9.5 1.32E-02 8.69% 3267 10591960 Vps26b 0.2 1.1 9.5 1.32E-02 8.69% 3268 10476349 1110034G24Rik -0.3 0.8 6.8 1.32E-02 8.69% 3269 10453766 Thoc1 0.3 1.2 7.1 1.32E-02 8.70%

Page 80 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3270 10501971 Ank2 0.3 1.2 6.8 1.32E-02 8.71% 3271 10503866 -0.2 0.8 4.8 1.32E-02 8.71% 3272 10387505 Atp1b2 -0.2 0.9 6.4 1.32E-02 8.71% 3273 10440300 0.4 1.3 7.5 1.33E-02 8.71% 3274 10394988 -0.3 0.8 6.3 1.33E-02 8.71% 3275 10558548 Kndc1 -0.2 0.8 5.3 1.33E-02 8.71% 3276 10424575 0.2 1.1 2.6 1.33E-02 8.71% 3277 10418747 Hacl1 0.3 1.3 12.6 1.33E-02 8.71% 3278 10521969 Immp1l 0.2 1.1 8.2 1.33E-02 8.71% 3279 10432492 Faim2 -0.2 0.9 5.5 1.33E-02 8.71% 3280 10547820 Lrrc23 -0.3 0.8 5.1 1.33E-02 8.71% 3281 10377534 A030009H04Rik -0.2 0.9 5.2 1.33E-02 8.71% 3282 10399661 0.3 1.2 2.7 1.33E-02 8.71% 3283 10582647 -0.2 0.9 5.2 1.33E-02 8.71% 3284 10389835 Kif2b -0.2 0.9 5.6 1.33E-02 8.71% 3285 10598018 0.5 1.4 9.2 1.33E-02 8.71% 3286 10544252 E330009J07Rik -0.2 0.9 6.9 1.33E-02 8.71% 3287 10477536 5430413K10Rik -0.3 0.8 4.3 1.33E-02 8.71% 3288 10535084 3110082I17Rik -0.3 0.8 7.4 1.33E-02 8.71% 3289 10466280 Olfr1425 -0.2 0.9 5.6 1.33E-02 8.71% 3290 10418950 Ldb3 -0.2 0.9 6.2 1.33E-02 8.71% 3291 10398352 Mir370 -0.3 0.8 5.7 1.33E-02 8.71% 3292 10600733 Gm5072 -0.2 0.9 4.0 1.33E-02 8.72% 3293 10557488 Tbx6 -0.2 0.9 6.2 1.33E-02 8.72% 3294 10351588 Pvrl4 -0.3 0.8 6.2 1.33E-02 8.72% 3295 10349980 Mybph -0.2 0.9 6.6 1.34E-02 8.72% 3296 10517421 Pnrc2 0.2 1.2 10.5 1.34E-02 8.73% 3297 10492668 -0.2 0.9 4.5 1.34E-02 8.73% 3298 10526502 Rabl5 0.2 1.1 7.7 1.34E-02 8.73% 3299 10398039 Serpina3f 0.4 1.3 6.2 1.34E-02 8.73% 3300 10398727 Klc1 0.3 1.2 8.2 1.34E-02 8.74% 3301 10350149 Tnni1 -0.2 0.9 6.3 1.34E-02 8.74% 3302 10448186 Zfp820 0.4 1.3 6.5 1.34E-02 8.74% 3303 10531087 Sult1b1 0.3 1.3 9.6 1.34E-02 8.76% 3304 10430811 Nhp2l1 0.3 1.2 10.0 1.35E-02 8.76% 3305 10461777 Olfr1444 -0.3 0.8 4.1 1.35E-02 8.76% 3306 10532919 Rps23 0.2 1.1 10.3 1.35E-02 8.76% 3307 10386442 Cops3 0.2 1.2 9.7 1.35E-02 8.77% 3308 10340160 -0.4 0.8 6.5 1.35E-02 8.77% 3309 10454254 Dtna -0.2 0.9 5.4 1.35E-02 8.77% 3310 10367641 Mthfd1l -0.2 0.9 6.7 1.35E-02 8.77%

Page 81 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3311 10473230 Nup35 0.4 1.3 8.0 1.35E-02 8.77% 3312 10520483 Ept1 0.3 1.2 10.6 1.35E-02 8.77% 3313 10350113 Arl8a 0.3 1.2 9.0 1.35E-02 8.77% 3314 10360909 9630028B13Rik -0.3 0.8 6.0 1.35E-02 8.78% 3315 10439471 Poglut1 0.2 1.2 8.5 1.35E-02 8.78% 3316 10408557 Serpinb1a 0.8 1.8 6.7 1.35E-02 8.78% 3317 10501074 Cym -0.2 0.9 6.7 1.35E-02 8.79% 3318 10382890 Sec14l1 0.2 1.2 7.5 1.36E-02 8.79% 3319 10551487 Eid2b 0.3 1.2 7.6 1.36E-02 8.79% 3320 10450365 0.8 1.7 9.3 1.36E-02 8.79% 3321 10463066 Tctn3 -0.2 0.8 5.2 1.36E-02 8.81% 3322 10488010 Hao1 -0.2 0.9 10.8 1.36E-02 8.81% 3323 10501649 Rtcd1 0.2 1.2 8.0 1.36E-02 8.81% 3324 10422059 Kctd12 0.2 1.1 8.3 1.36E-02 8.81% 3325 10462630 Pank1 -0.5 0.7 7.6 1.36E-02 8.81% 3326 10583785 2310047B19Rik 0.3 1.2 7.3 1.36E-02 8.81% 3327 10465580 Nudt22 0.2 1.2 7.8 1.36E-02 8.81% 3328 10573975 Ces5a -0.2 0.9 6.1 1.36E-02 8.81% 3329 10511870 Fut9 -0.3 0.8 4.6 1.37E-02 8.82% 3330 10478590 Zswim1 0.2 1.2 6.0 1.37E-02 8.82% 3331 10384123 Ddx56 0.2 1.2 9.1 1.37E-02 8.82% 3332 10515528 Dph2 0.2 1.2 6.6 1.37E-02 8.83% 3333 10571774 Aga 0.2 1.2 8.1 1.37E-02 8.83% 3334 10455989 Rbm22 0.2 1.1 8.7 1.37E-02 8.83% 3335 10542006 D6Wsu163e 0.3 1.2 8.0 1.37E-02 8.83% 3336 10590974 Folr4 -0.2 0.9 5.7 1.37E-02 8.84% 3337 10603249 Mycs -0.2 0.9 6.6 1.37E-02 8.84% 3338 10372324 Syt1 0.4 1.3 8.8 1.37E-02 8.84% 3339 10574149 Nlrc5 0.4 1.3 7.5 1.37E-02 8.84% 3340 10344175 0.4 1.4 8.1 1.37E-02 8.85% 3341 10567171 Snord14a 0.4 1.3 6.7 1.38E-02 8.87% 3342 10341090 -0.7 0.6 7.3 1.38E-02 8.87% 3343 10500547 Hsd3b2 -0.6 0.7 8.9 1.38E-02 8.87% 3344 10354521 Inpp1 0.3 1.2 7.7 1.38E-02 8.87% 3345 10421615 Spert -0.2 0.9 5.7 1.38E-02 8.89% 3346 10391612 Atxn7l3 0.2 1.2 7.7 1.38E-02 8.89% 3347 10348702 Agxt 0.3 1.2 10.8 1.38E-02 8.89% 3348 10421661 Gtf2f2 0.2 1.2 7.7 1.38E-02 8.89% 3349 10529287 Fam53a 0.2 1.1 7.2 1.39E-02 8.90% 3350 10362937 -0.2 0.9 6.5 1.39E-02 8.90% 3351 10408531 Gmds 0.4 1.3 6.6 1.39E-02 8.90%

Page 82 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3352 10579996 Tecr -0.2 0.9 11.5 1.39E-02 8.90% 3353 10416120 -0.2 0.9 5.5 1.39E-02 8.91% 3354 10479463 Slc17a9 0.4 1.4 7.6 1.39E-02 8.91% 3355 10442493 1.1 2.1 5.7 1.39E-02 8.91% 3356 10579969 Zfp330 0.5 1.5 8.4 1.39E-02 8.91% 3357 10429944 Scrt1 -0.2 0.9 5.4 1.39E-02 8.91% 3358 10441233 Mx1 0.3 1.2 4.6 1.39E-02 8.91% 3359 10338307 0.5 1.4 4.0 1.39E-02 8.91% 3360 10600504 Fundc2 0.3 1.2 7.4 1.39E-02 8.91% 3361 10508042 Meaf6 0.2 1.1 7.8 1.39E-02 8.91% 3362 10587688 0.6 1.5 7.8 1.39E-02 8.91% 3363 10595620 0.6 1.5 7.8 1.39E-02 8.91% 3364 10582403 Galns 0.3 1.2 7.2 1.39E-02 8.91% 3365 10377255 Stx8 0.2 1.1 8.1 1.39E-02 8.91% 3366 10483648 Ola1 0.3 1.2 8.9 1.40E-02 8.91% 3367 10563893 0.2 1.2 3.3 1.40E-02 8.91% 3368 10350800 Tor1aip2 -0.2 0.9 9.5 1.40E-02 8.91% 3369 10370471 Agpat3 0.2 1.1 11.2 1.40E-02 8.91% 3370 10438784 Gm606 -0.2 0.9 4.4 1.40E-02 8.91% 3371 10388994 -0.2 0.8 6.5 1.40E-02 8.91% 3372 10598077 0.8 1.7 9.1 1.40E-02 8.91% 3373 10398599 Rps19 0.2 1.1 8.4 1.40E-02 8.91% 3374 10344015 0.9 1.8 5.8 1.40E-02 8.91% 3375 10406854 Rpl27a 0.2 1.1 10.5 1.40E-02 8.91% 3376 10473456 Olfr1009 -0.2 0.9 4.6 1.40E-02 8.91% 3377 10371296 Glt8d2 -0.2 0.9 5.2 1.40E-02 8.91% 3378 10545771 Cyp26b1 -0.3 0.8 6.8 1.40E-02 8.91% 3379 10416044 Ccdc25 0.4 1.3 8.3 1.40E-02 8.91% 3380 10384762 -0.3 0.8 6.5 1.40E-02 8.91% 3381 10394471 Sdc1 0.2 1.2 10.7 1.40E-02 8.92% 3382 10340416 -0.5 0.7 5.4 1.40E-02 8.92% 3383 10493114 Nes -0.3 0.8 5.6 1.40E-02 8.93% 3384 10566315 E030002O03Rik -0.2 0.9 5.8 1.41E-02 8.94% 3385 10542264 2700089E24Rik -0.2 0.9 9.3 1.41E-02 8.94% 3386 10568024 Coro1a 0.3 1.2 6.5 1.41E-02 8.94% 3387 10542079 Foxm1 0.4 1.4 5.9 1.41E-02 8.96% 3388 10519717 Sema3a -0.2 0.9 5.2 1.41E-02 8.97% 3389 10552240 Zfp507 -0.3 0.8 8.0 1.42E-02 8.97% 3390 10376887 Snord49a 0.7 1.6 6.6 1.42E-02 8.97% 3391 10342770 0.3 1.3 6.6 1.42E-02 8.97% 3392 10343690 -0.4 0.8 8.3 1.42E-02 8.97%

Page 83 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3393 10573956 Slc6a2 -0.2 0.9 6.0 1.42E-02 8.97% 3394 10369890 -0.3 0.8 6.9 1.42E-02 8.97% 3395 10403825 Tcrg-V1 0.3 1.2 4.9 1.42E-02 8.97% 3396 10463517 Pprc1 0.3 1.3 7.0 1.42E-02 8.97% 3397 10566564 Mrpl17 0.2 1.1 8.7 1.42E-02 8.97% 3398 10459227 Mir143 -0.2 0.9 6.3 1.42E-02 8.97% 3399 10571207 Dusp26 -0.2 0.8 6.4 1.42E-02 8.97% 3400 10477813 Rbm39 0.3 1.3 4.9 1.42E-02 8.97% 3401 10598175 Ear10 0.3 1.2 4.7 1.42E-02 8.97% 3402 10454709 Kif20a 0.9 1.8 6.5 1.42E-02 8.98% 3403 10496890 Gipc2 -0.2 0.8 5.5 1.42E-02 9.00% 3404 10562211 Fxyd1 -0.1 0.9 11.4 1.43E-02 9.00% 3405 10339680 -0.3 0.8 9.9 1.43E-02 9.00% 3406 10534575 Prkrip1 0.2 1.2 6.8 1.43E-02 9.00% 3407 10563597 Saa3 0.7 1.6 7.7 1.43E-02 9.00% 3408 10418846 -0.3 0.8 5.9 1.43E-02 9.00% 3409 10525464 Orai1 0.2 1.2 7.3 1.43E-02 9.00% 3410 10608714 1810009N02Rik -0.2 0.9 7.3 1.43E-02 9.00% 3411 10443122 Ggnbp1 -0.2 0.9 6.1 1.43E-02 9.00% 3412 10554233 Aen 0.3 1.2 7.2 1.43E-02 9.00% 3413 10451805 Sgol1 0.3 1.3 5.8 1.43E-02 9.00% 3414 10404697 -0.2 0.9 5.3 1.43E-02 9.00% 3415 10340616 -0.5 0.7 7.0 1.43E-02 9.00% 3416 10603166 Trappc2 0.3 1.2 9.2 1.43E-02 9.00% 3417 10416155 Kctd9 0.3 1.2 8.4 1.43E-02 9.00% 3418 10383564 Fn3k -0.2 0.8 7.6 1.43E-02 9.00% 3419 10452000 Dpp9 0.2 1.2 8.1 1.43E-02 9.00% 3420 10407319 Rpl34 0.2 1.1 10.8 1.43E-02 9.00% 3421 10537805 Olfr447 -0.2 0.9 5.0 1.43E-02 9.00% 3422 10577030 Cars2 0.2 1.2 7.7 1.43E-02 9.00% 3423 10596318 Nudt16 -0.3 0.8 7.6 1.43E-02 9.00% 3424 10474700 Thbs1 0.4 1.3 6.5 1.43E-02 9.01% 3425 10388679 Abhd15 -0.3 0.8 6.8 1.44E-02 9.02% 3426 10451238 Polr1c 0.2 1.2 9.3 1.44E-02 9.02% 3427 10570663 Defa25 -0.3 0.8 5.8 1.44E-02 9.03% 3428 10340523 -0.4 0.8 11.5 1.44E-02 9.03% 3429 10408060 Olfr1364 -0.2 0.8 5.9 1.44E-02 9.03% 3430 10552245 Tshz3 -0.2 0.9 6.7 1.44E-02 9.03% 3431 10415282 Psme1 0.2 1.2 9.4 1.44E-02 9.03% 3432 10555039 Kctd21 0.3 1.2 6.6 1.44E-02 9.04% 3433 10430324 Tmprss6 -0.2 0.9 10.2 1.44E-02 9.04%

Page 84 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3434 10515979 Mir30c-1 -0.3 0.8 5.1 1.44E-02 9.04% 3435 10460947 Pygm -0.5 0.7 6.2 1.45E-02 9.05% 3436 10476939 Zfp937 0.4 1.3 7.9 1.45E-02 9.05% 3437 10587792 Plscr1 0.3 1.3 9.4 1.45E-02 9.05% 3438 10367436 Cd63 -0.3 0.8 6.3 1.45E-02 9.05% 3439 10341117 -0.4 0.8 7.0 1.45E-02 9.06% 3440 10454881 0610010O12Rik -0.3 0.8 8.1 1.45E-02 9.06% 3441 10345401 Fam123c -0.3 0.8 5.7 1.45E-02 9.06% 3442 10500295 Plekho1 0.1 1.1 7.7 1.45E-02 9.06% 3443 10413967 -0.2 0.9 5.6 1.45E-02 9.06% 3444 10338886 -0.5 0.7 5.1 1.45E-02 9.06% 3445 10505517 Tlr4 0.3 1.2 5.7 1.45E-02 9.07% 3446 10435748 -0.3 0.8 5.3 1.45E-02 9.07% 3447 10503220 Chd7 -0.2 0.9 7.6 1.45E-02 9.07% 3448 10353343 Gm2657 -0.2 0.9 5.9 1.45E-02 9.07% 3449 10608718 Pglyrp2 -0.3 0.8 9.9 1.45E-02 9.07% 3450 10524071 Vmn2r17 0.2 1.2 4.1 1.46E-02 9.08% 3451 10569134 Deaf1 -0.2 0.9 7.8 1.46E-02 9.08% 3452 10568252 Zfp689 -0.2 0.9 6.5 1.46E-02 9.08% 3453 10543017 Pdk4 -0.7 0.6 7.5 1.46E-02 9.08% 3454 10551304 Cyp2t4 -0.3 0.8 4.9 1.46E-02 9.09% 3455 10340839 0.6 1.5 3.2 1.46E-02 9.09% 3456 10343312 -0.5 0.7 7.3 1.46E-02 9.09% 3457 10361186 Sertad4 -0.3 0.8 5.9 1.46E-02 9.10% 3458 10511113 Cdk11b 0.3 1.2 7.6 1.46E-02 9.10% 3459 10415248 Pck2 -0.2 0.9 6.9 1.46E-02 9.11% 3460 10451301 Rpl11 0.2 1.1 10.5 1.47E-02 9.11% 3461 10338627 -0.5 0.7 9.2 1.47E-02 9.11% 3462 10339349 0.2 1.1 10.2 1.47E-02 9.11% 3463 10539279 Aup1 -0.1 0.9 11.6 1.47E-02 9.11% 3464 10461078 Atl3 -0.2 0.9 10.0 1.47E-02 9.11% 3465 10544596 Tmem176b 0.2 1.2 11.7 1.47E-02 9.12% 3466 10377516 Kcnab3 -0.3 0.8 5.5 1.47E-02 9.12% 3467 10520096 Klhl7 0.2 1.1 7.9 1.47E-02 9.12% 3468 10412981 Sec24c 0.2 1.1 10.5 1.47E-02 9.12% 3469 10407350 Fgf10 -0.2 0.9 4.7 1.47E-02 9.12% 3470 10474123 Commd9 0.2 1.2 8.2 1.47E-02 9.12% 3471 10467173 Mir107 -0.6 0.7 6.8 1.47E-02 9.12% 3472 10452815 Xdh -0.3 0.8 9.9 1.47E-02 9.13% 3473 10552270 Zfp619 -0.2 0.9 6.1 1.48E-02 9.14% 3474 10499128 Snord73a 0.3 1.2 4.7 1.48E-02 9.14%

Page 85 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3475 10512129 B4galt1 0.3 1.3 9.3 1.48E-02 9.14% 3476 10581455 Esrp2 0.2 1.1 9.5 1.48E-02 9.14% 3477 10511723 -0.2 0.9 7.0 1.48E-02 9.14% 3478 10502105 Egf -0.2 0.8 6.6 1.48E-02 9.14% 3479 10601303 Chic1 0.4 1.3 7.5 1.48E-02 9.14% 3480 10344529 -0.4 0.8 2.9 1.48E-02 9.14% 3481 10357371 Tmem163 -0.2 0.9 6.4 1.48E-02 9.14% 3482 10376007 Shroom1 0.2 1.2 8.7 1.48E-02 9.14% 3483 10366737 -0.4 0.8 7.7 1.48E-02 9.14% 3484 10453747 Colec12 -0.3 0.8 9.7 1.48E-02 9.14% 3485 10341344 0.4 1.3 5.8 1.48E-02 9.14% 3486 10570308 Proz 0.1 1.1 11.3 1.48E-02 9.16% 3487 10428534 Trps1 0.4 1.3 5.4 1.48E-02 9.16% 3488 10531290 Rchy1 0.2 1.2 8.1 1.49E-02 9.16% 3489 10345368 0.3 1.2 8.2 1.49E-02 9.16% 3490 10489705 Slc13a3 -0.4 0.7 8.4 1.49E-02 9.17% 3491 10445992 Shd -0.2 0.8 6.6 1.49E-02 9.17% 3492 10572070 Npy1r -0.2 0.8 4.9 1.49E-02 9.18% 3493 10605606 -0.2 0.9 6.0 1.49E-02 9.19% 3494 10570618 Defb46 -0.3 0.8 6.4 1.49E-02 9.19% 3495 10340718 0.8 1.7 4.9 1.49E-02 9.19% 3496 10605324 Slc10a3 0.2 1.1 7.1 1.49E-02 9.19% 3497 10570671 Defa22 -0.3 0.8 6.4 1.50E-02 9.20% 3498 10532711 Cmklr1 0.2 1.2 6.8 1.50E-02 9.20% 3499 10592449 Olfr149 -0.3 0.8 6.2 1.50E-02 9.20% 3500 10385761 Ube2b -0.2 0.9 10.6 1.50E-02 9.21% 3501 10596207 Uba5 0.4 1.3 10.1 1.50E-02 9.21% 3502 10420320 Cenpj 0.3 1.2 6.5 1.50E-02 9.22% 3503 10581299 Agrp -0.2 0.8 5.3 1.50E-02 9.22% 3504 10463630 Mir146b -0.2 0.9 5.7 1.50E-02 9.23% 3505 10518642 Ube4b -0.4 0.8 9.8 1.51E-02 9.24% 3506 10442914 0610011F06Rik -0.2 0.9 9.6 1.51E-02 9.24% 3507 10521090 Tacc3 0.4 1.3 6.1 1.51E-02 9.24% 3508 10585601 Snupn 0.5 1.4 6.8 1.51E-02 9.25% 3509 10500999 1700027A23Rik -0.2 0.8 4.5 1.51E-02 9.25% 3510 10343961 -0.6 0.7 4.0 1.51E-02 9.25% 3511 10360270 Atp1a2 -0.2 0.8 6.3 1.51E-02 9.25% 3512 10598101 Maml2 -0.2 0.9 7.0 1.51E-02 9.25% 3513 10575550 Aars 0.3 1.2 9.2 1.51E-02 9.25% 3514 10458424 Taf7 0.3 1.2 6.5 1.51E-02 9.25% 3515 10356379 Ecel1 -0.2 0.9 6.7 1.51E-02 9.25%

Page 86 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3516 10400589 Mis18bp1 0.7 1.6 4.7 1.51E-02 9.25% 3517 10517457 Rpl11 0.2 1.1 10.2 1.51E-02 9.25% 3518 10475525 Pldn 0.2 1.1 8.3 1.51E-02 9.25% 3519 10358595 Hmcn1 -0.1 0.9 5.4 1.51E-02 9.25% 3520 10510413 Gm572 -0.2 0.9 6.1 1.52E-02 9.26% 3521 10544644 Dfna5 0.4 1.3 5.1 1.52E-02 9.26% 3522 10575777 4933407C03Rik -0.3 0.8 9.1 1.52E-02 9.27% 3523 10447042 2410091C18Rik 0.3 1.2 7.3 1.52E-02 9.31% 3524 10516932 Sesn2 -0.3 0.8 6.7 1.52E-02 9.31% 3525 10375838 Col23a1 -0.2 0.8 7.0 1.52E-02 9.31% 3526 10360506 Akt3 0.3 1.2 8.0 1.53E-02 9.31% 3527 10533003 1110006O24Rik -0.2 0.9 6.5 1.53E-02 9.31% 3528 10355152 Fzd5 0.2 1.1 7.1 1.53E-02 9.31% 3529 10528385 Reln -0.2 0.9 9.4 1.53E-02 9.31% 3530 10537938 Zfp956 -0.2 0.9 6.1 1.53E-02 9.33% 3531 10343259 -0.4 0.8 8.0 1.53E-02 9.33% 3532 10575376 Ftsjd1 0.4 1.3 7.5 1.53E-02 9.33% 3533 10467182 Htr7 -0.2 0.9 5.3 1.53E-02 9.33% 3534 10578219 -0.3 0.8 6.9 1.53E-02 9.33% 3535 10558670 Olfr541 -0.3 0.8 4.6 1.53E-02 9.34% 3536 10388869 Tnfaip1 0.1 1.1 8.7 1.54E-02 9.34% 3537 10373542 Dgka 0.3 1.2 8.9 1.54E-02 9.34% 3538 10553913 Mcee -0.1 0.9 11.9 1.54E-02 9.34% 3539 10338190 -0.4 0.8 5.6 1.54E-02 9.34% 3540 10353878 Ankrd23 -0.4 0.7 6.6 1.54E-02 9.34% 3541 10598650 Gm14483 -0.2 0.9 6.0 1.54E-02 9.34% 3542 10360248 Atp1a4 -0.2 0.9 5.5 1.54E-02 9.36% 3543 10548931 Slc15a5 -0.2 0.9 5.8 1.54E-02 9.36% 3544 10372716 Rap1b 0.3 1.2 10.2 1.54E-02 9.36% 3545 10404496 Nqo2 -0.3 0.8 10.5 1.54E-02 9.36% 3546 10567423 Dcun1d3 0.2 1.2 8.3 1.54E-02 9.36% 3547 10606355 Cysltr1 0.3 1.2 6.1 1.54E-02 9.36% 3548 10594142 Rpl11 0.2 1.1 10.4 1.54E-02 9.37% 3549 10415377 2610027L16Rik 0.2 1.2 7.5 1.55E-02 9.39% 3550 10378088 Mybbp1a 0.3 1.2 8.4 1.55E-02 9.39% 3551 10463343 Gm10768 -0.3 0.8 9.6 1.55E-02 9.40% 3552 10518526 Angptl7 -0.3 0.8 5.8 1.55E-02 9.40% 3553 10481830 Zbtb43 -0.2 0.9 8.3 1.55E-02 9.40% 3554 10416919 -0.2 0.9 7.5 1.55E-02 9.41% 3555 10412735 -0.2 0.9 4.5 1.56E-02 9.41% 3556 10471586 Hspa5 0.4 1.3 12.5 1.56E-02 9.41%

Page 87 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3557 10340056 -0.3 0.8 5.0 1.56E-02 9.41% 3558 10351117 Dnm3 -0.3 0.8 5.4 1.56E-02 9.41% 3559 10404038 Hist1h3d 0.3 1.2 6.3 1.56E-02 9.41% 3560 10458398 Hars 0.2 1.1 8.5 1.56E-02 9.41% 3561 10401267 Dcaf5 0.2 1.2 8.8 1.56E-02 9.41% 3562 10339032 0.9 1.9 3.6 1.56E-02 9.41% 3563 10499552 Efna4 -0.2 0.8 6.3 1.56E-02 9.42% 3564 10441657 Prr18 -0.2 0.8 6.5 1.56E-02 9.42% 3565 10581027 Rplp0 0.2 1.1 12.0 1.56E-02 9.42% 3566 10369825 Gm5172 -0.3 0.8 6.8 1.56E-02 9.42% 3567 10465559 Vegfb -0.2 0.9 8.4 1.56E-02 9.42% 3568 10357478 Rpl31 0.2 1.1 10.5 1.56E-02 9.43% 3569 10501895 Myoz2 -0.6 0.7 5.0 1.56E-02 9.43% 3570 10459375 Txnl1 0.3 1.2 9.3 1.56E-02 9.43% 3571 10365037 Matk -0.2 0.9 6.7 1.57E-02 9.43% 3572 10454414 Pik3c3 -0.2 0.9 7.7 1.57E-02 9.43% 3573 10338923 -0.4 0.7 6.7 1.57E-02 9.43% 3574 10341718 0.2 1.2 8.4 1.57E-02 9.43% 3575 10585224 Fdxacb1 0.2 1.2 6.1 1.57E-02 9.45% 3576 10508788 Ahdc1 -0.2 0.9 7.3 1.57E-02 9.45% 3577 10508142 Col8a2 -0.3 0.8 6.1 1.57E-02 9.45% 3578 10467258 Myof 0.3 1.2 6.7 1.57E-02 9.46% 3579 10383202 0.3 1.2 9.2 1.57E-02 9.46% 3580 10511416 Tox -0.4 0.7 8.3 1.57E-02 9.46% 3581 10501117 Ubl4b -0.2 0.9 5.3 1.58E-02 9.46% 3582 10341455 -0.3 0.8 8.1 1.58E-02 9.46% 3583 10415897 Prss51 -0.2 0.8 6.1 1.58E-02 9.46% 3584 10499643 Chrnb2 -0.2 0.9 6.5 1.58E-02 9.46% 3585 10505747 Rraga 0.3 1.3 8.6 1.58E-02 9.46% 3586 10505717 Adamtsl1 -0.2 0.9 6.3 1.58E-02 9.46% 3587 10502900 -0.2 0.8 5.3 1.58E-02 9.47% 3588 10550760 Vmn1r100 0.4 1.3 3.9 1.58E-02 9.47% 3589 10343676 0.4 1.3 2.8 1.58E-02 9.47% 3590 10370837 Tcf3 0.2 1.1 7.8 1.58E-02 9.47% 3591 10339963 0.3 1.2 10.6 1.58E-02 9.48% 3592 10452404 Nudt12 -0.2 0.9 9.5 1.58E-02 9.48% 3593 10497012 4922501L14Rik -0.2 0.9 5.7 1.58E-02 9.49% 3594 10589610 Prss42 -0.3 0.8 5.0 1.59E-02 9.49% 3595 10486895 Mageb3 -0.3 0.8 5.0 1.59E-02 9.49% 3596 10601854 Wbp5 0.4 1.3 7.7 1.59E-02 9.49% 3597 10377181 Myh13 -0.2 0.9 5.5 1.59E-02 9.49%

Page 88 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3598 10406434 Mef2c -0.2 0.9 6.5 1.59E-02 9.49% 3599 10542983 Pon1 -0.2 0.9 12.9 1.59E-02 9.49% 3600 10415649 Zdhhc20 -0.2 0.9 6.2 1.59E-02 9.50% 3601 10356520 Col6a3 -0.2 0.9 6.8 1.59E-02 9.50% 3602 10368011 Vta1 0.2 1.2 8.5 1.59E-02 9.51% 3603 10525831 -0.5 0.7 4.7 1.59E-02 9.51% 3604 10339176 -0.4 0.8 9.5 1.59E-02 9.51% 3605 10468651 -0.3 0.8 6.0 1.59E-02 9.51% 3606 10500253 Prpf3 0.3 1.2 7.8 1.59E-02 9.51% 3607 10420614 Sacs -0.2 0.9 7.7 1.59E-02 9.51% 3608 10577994 Gm8096 -0.2 0.9 6.5 1.60E-02 9.51% 3609 10435617 Rabl3 0.2 1.2 9.2 1.60E-02 9.51% 3610 10519879 Speer4f -0.2 0.9 4.4 1.60E-02 9.51% 3611 10431300 Alg12 0.5 1.4 8.8 1.60E-02 9.51% 3612 10406622 Cmya5 -0.3 0.8 6.0 1.60E-02 9.53% 3613 10463121 Zfp518a 0.3 1.3 7.3 1.60E-02 9.53% 3614 10582171 Zdhhc7 0.2 1.1 7.9 1.60E-02 9.53% 3615 10338367 0.4 1.3 6.0 1.60E-02 9.53% 3616 10525076 Sds -0.5 0.7 10.7 1.60E-02 9.54% 3617 10383282 Chmp6 -0.2 0.9 7.8 1.60E-02 9.54% 3618 10539653 Tprkb -0.2 0.9 10.0 1.60E-02 9.54% 3619 10340387 0.2 1.2 10.4 1.60E-02 9.54% 3620 10530892 Cenpc1 0.3 1.3 6.1 1.61E-02 9.54% 3621 10398390 Mir323 -0.2 0.8 3.5 1.61E-02 9.54% 3622 10541144 Cacna2d4 -0.2 0.8 6.0 1.61E-02 9.54% 3623 10375567 Olfr1384 -0.3 0.8 5.3 1.61E-02 9.54% 3624 10491414 Usp13 -0.2 0.9 5.0 1.61E-02 9.54% 3625 10341125 -0.5 0.7 3.1 1.61E-02 9.54% 3626 10355931 Farsb 0.2 1.2 9.1 1.61E-02 9.54% 3627 10559676 Ube2s 0.2 1.2 8.0 1.61E-02 9.54% 3628 10380226 Cuedc1 -0.2 0.9 6.4 1.61E-02 9.54% 3629 10413482 Wnt5a 0.4 1.3 6.0 1.61E-02 9.54% 3630 10346651 Bmpr2 -0.2 0.9 9.4 1.61E-02 9.54% 3631 10572445 Lrrc25 0.3 1.2 5.9 1.61E-02 9.54% 3632 10534061 Zfp11 0.3 1.2 6.0 1.61E-02 9.55% 3633 10471108 Gpr107 0.1 1.1 8.5 1.61E-02 9.55% 3634 10341856 0.6 1.5 3.1 1.61E-02 9.55% 3635 10492983 Fcrl5 -0.2 0.9 5.2 1.61E-02 9.55% 3636 10341712 -0.4 0.7 4.9 1.62E-02 9.56% 3637 10603306 Mir362 0.3 1.2 5.5 1.62E-02 9.56% 3638 10427772 Tars 0.6 1.5 9.3 1.62E-02 9.56%

Page 89 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3639 10381311 Wnk4 -0.2 0.9 6.1 1.62E-02 9.57% 3640 10452087 Safb2 -0.2 0.9 7.7 1.62E-02 9.57% 3641 10460010 Galr1 -0.3 0.8 4.5 1.62E-02 9.57% 3642 10395142 Sh3yl1 0.3 1.2 7.6 1.62E-02 9.58% 3643 10368175 Pde7b -0.3 0.8 8.2 1.62E-02 9.58% 3644 10423274 Cdh18 -0.2 0.9 5.0 1.62E-02 9.58% 3645 10491920 Elf2 -0.2 0.9 6.5 1.62E-02 9.58% 3646 10412380 0.4 1.3 8.3 1.62E-02 9.58% 3647 10381371 Aoc3 -0.3 0.8 5.6 1.63E-02 9.59% 3648 10383681 Patz1 -0.2 0.9 5.6 1.63E-02 9.60% 3649 10576288 Spire2 -0.2 0.8 6.5 1.63E-02 9.61% 3650 10391762 Gjc1 -0.2 0.9 4.9 1.63E-02 9.62% 3651 10592790 Hinfp 0.2 1.1 7.3 1.63E-02 9.62% 3652 10598111 Dhrsx -0.2 0.8 8.0 1.63E-02 9.62% 3653 10408212 Hist1h2be 0.3 1.2 7.4 1.63E-02 9.62% 3654 10556033 Olfr707 -0.2 0.9 5.6 1.63E-02 9.62% 3655 10340756 -0.5 0.7 6.1 1.64E-02 9.63% 3656 10469568 -0.3 0.8 7.6 1.64E-02 9.64% 3657 10507177 Cyp4a32 0.5 1.4 12.3 1.64E-02 9.64% 3658 10432511 Racgap1 0.6 1.5 6.2 1.64E-02 9.65% 3659 10601616 -0.3 0.8 9.0 1.64E-02 9.65% 3660 10403073 Ighg 0.3 1.2 3.3 1.64E-02 9.65% 3661 10343559 -0.3 0.8 6.5 1.64E-02 9.65% 3662 10495854 Prss12 -0.3 0.8 6.2 1.64E-02 9.65% 3663 10408709 Ssr1 0.2 1.2 11.1 1.64E-02 9.65% 3664 10507653 0.3 1.3 6.2 1.64E-02 9.65% 3665 10350646 Edem3 0.3 1.3 9.0 1.65E-02 9.65% 3666 10397450 Vash1 -0.2 0.9 6.4 1.65E-02 9.65% 3667 10590623 Cxcr6 0.4 1.3 5.8 1.65E-02 9.65% 3668 10448269 Zfp13 -0.2 0.9 6.9 1.65E-02 9.65% 3669 10423505 Cmbl 0.2 1.2 12.2 1.65E-02 9.65% 3670 10358539 Hmcn1 -0.3 0.8 6.2 1.65E-02 9.65% 3671 10385248 Hmmr 1.1 2.1 5.0 1.65E-02 9.65% 3672 10358038 Rnpep 0.3 1.2 8.4 1.65E-02 9.65% 3673 10343881 -0.3 0.8 7.2 1.65E-02 9.65% 3674 10368511 Trmt11 0.3 1.3 6.7 1.65E-02 9.65% 3675 10434281 0.3 1.2 7.0 1.65E-02 9.65% 3676 10583320 BC017612 0.4 1.3 6.7 1.65E-02 9.65% 3677 10499883 Adrm1 0.2 1.1 9.4 1.65E-02 9.65% 3678 10565712 Acer3 0.4 1.3 7.8 1.65E-02 9.65% 3679 10445137 Olfr109 -0.3 0.8 5.6 1.65E-02 9.65%

Page 90 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3680 10453260 Haao -0.2 0.9 11.9 1.65E-02 9.65% 3681 10338136 -0.3 0.8 7.4 1.65E-02 9.65% 3682 10339300 -0.4 0.8 7.6 1.65E-02 9.65% 3683 10450145 Psmb9 0.3 1.2 8.5 1.65E-02 9.65% 3684 10607346 Tspyl2 0.4 1.3 7.7 1.65E-02 9.65% 3685 10563961 0.2 1.2 2.4 1.65E-02 9.65% 3686 10476443 Plcb4 -0.2 0.9 6.4 1.65E-02 9.65% 3687 10568217 Dctpp1 -0.2 0.8 8.5 1.65E-02 9.65% 3688 10474112 Traf6 0.2 1.1 8.6 1.66E-02 9.66% 3689 10495279 Psma5 0.3 1.2 8.7 1.66E-02 9.67% 3690 10558295 -0.3 0.8 10.1 1.66E-02 9.67% 3691 10437263 1700037C18Rik -0.2 0.8 6.4 1.66E-02 9.67% 3692 10479154 Tubb1 0.2 1.1 6.7 1.66E-02 9.67% 3693 10582981 Tfdp1 0.2 1.2 8.6 1.66E-02 9.67% 3694 10434094 Klhl22 0.2 1.1 8.3 1.66E-02 9.67% 3695 10414001 Gm626 -0.2 0.9 4.3 1.66E-02 9.68% 3696 10573703 Tmem188 0.2 1.2 9.4 1.66E-02 9.68% 3697 10343635 0.4 1.3 9.0 1.66E-02 9.68% 3698 10343554 0.6 1.5 3.2 1.66E-02 9.68% 3699 10338464 -0.5 0.7 5.5 1.66E-02 9.68% 3700 10429621 Mafa -0.2 0.9 6.5 1.67E-02 9.69% 3701 10344296 0.6 1.5 5.8 1.67E-02 9.70% 3702 10521725 Med28 0.2 1.2 8.1 1.67E-02 9.72% 3703 10550062 Zfp324 0.2 1.2 7.8 1.67E-02 9.72% 3704 10410547 Nkd2 -0.3 0.8 5.5 1.67E-02 9.72% 3705 10565330 Zfand6 -0.2 0.8 9.7 1.67E-02 9.72% 3706 10595439 -0.3 0.8 6.4 1.68E-02 9.73% 3707 10344315 -0.4 0.8 8.4 1.68E-02 9.73% 3708 10531910 Hsd17b13 -0.3 0.8 10.6 1.68E-02 9.74% 3709 10512886 Acnat2 0.3 1.3 10.3 1.68E-02 9.75% 3710 10585974 Myo9a 0.3 1.2 6.0 1.68E-02 9.75% 3711 10586781 Myo1e -0.3 0.8 9.0 1.68E-02 9.76% 3712 10567049 Copb1 0.2 1.2 10.8 1.68E-02 9.76% 3713 10474064 Trp53i11 -0.3 0.8 7.9 1.68E-02 9.76% 3714 10441064 Dscr3 0.2 1.2 8.7 1.69E-02 9.77% 3715 10588874 Bsn -0.3 0.8 7.5 1.69E-02 9.77% 3716 10436762 -0.2 0.9 5.6 1.69E-02 9.77% 3717 10394532 Ube2f 0.4 1.3 10.1 1.69E-02 9.77% 3718 10458960 Aldh7a1 -0.2 0.9 11.5 1.69E-02 9.77% 3719 10379615 Slfn5 0.2 1.2 7.3 1.69E-02 9.78% 3720 10343968 0.2 1.2 11.0 1.69E-02 9.78%

Page 91 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3721 10380927 Grb7 -0.3 0.8 9.9 1.69E-02 9.78% 3722 10424400 Myc 1.2 2.3 8.5 1.69E-02 9.78% 3723 10453399 Srbd1 -0.2 0.9 8.2 1.69E-02 9.78% 3724 10464601 0.3 1.2 7.0 1.69E-02 9.78% 3725 10356278 Sp110 0.2 1.1 7.1 1.69E-02 9.78% 3726 10497520 Ect2 0.9 1.9 7.6 1.69E-02 9.78% 3727 10475648 Dtwd1 0.3 1.2 7.8 1.69E-02 9.78% 3728 10608100 Zfy1 0.2 1.2 3.7 1.70E-02 9.78% 3729 10608696 Snrnp40 0.2 1.1 7.4 1.70E-02 9.79% 3730 10409990 6720489N17Rik 0.4 1.3 5.9 1.70E-02 9.80% 3731 10343101 -0.5 0.7 3.6 1.70E-02 9.80% 3732 10588226 Amotl2 -0.3 0.8 7.4 1.70E-02 9.81% 3733 10574498 Ces2a -0.4 0.8 9.8 1.70E-02 9.81% 3734 10422312 Cldn10 -0.2 0.9 4.5 1.70E-02 9.81% 3735 10561513 Mrps12 0.3 1.2 7.0 1.71E-02 9.82% 3736 10343883 0.4 1.3 7.6 1.71E-02 9.82% 3737 10592618 Tbcel 0.3 1.2 9.3 1.71E-02 9.82% 3738 10502778 Lphn2 0.3 1.3 9.4 1.71E-02 9.83% 3739 10601607 4921511C20Rik 0.2 1.2 3.3 1.71E-02 9.83% 3740 10468415 Wdr96 0.2 1.1 3.3 1.71E-02 9.83% 3741 10477946 Rpn2 0.2 1.1 10.7 1.71E-02 9.83% 3742 10503502 Ttpa 0.2 1.1 12.5 1.71E-02 9.83% 3743 10584526 Olfr982 -0.2 0.9 6.2 1.71E-02 9.83% 3744 10515706 Szt2 -0.2 0.8 8.1 1.71E-02 9.83% 3745 10349340 C1ql2 -0.3 0.8 6.6 1.71E-02 9.83% 3746 10532896 2610524H06Rik 0.3 1.2 6.0 1.71E-02 9.83% 3747 10372733 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3748 10372735 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3749 10372737 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3750 10372739 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3751 10372741 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3752 10372743 Cdc5l 0.3 1.2 8.1 1.71E-02 9.83% 3753 10582862 Arhgef12 0.4 1.3 7.1 1.72E-02 9.83% 3754 10560754 Vmn1r132 0.3 1.2 4.7 1.72E-02 9.83% 3755 10358589 Hmcn1 -0.2 0.8 7.0 1.72E-02 9.83% 3756 10532472 Ulk1 -0.4 0.8 9.0 1.72E-02 9.83% 3757 10392815 AF251705 0.2 1.2 6.1 1.72E-02 9.83% 3758 10516678 Kpna6 0.2 1.2 8.9 1.72E-02 9.83% 3759 10580795 Ccdc102a -0.2 0.8 6.0 1.72E-02 9.83% 3760 10343904 -0.4 0.8 9.1 1.72E-02 9.83% 3761 10525381 Vps29 0.2 1.1 9.8 1.72E-02 9.83%

Page 92 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3762 10495332 1700013F07Rik -0.3 0.8 5.5 1.72E-02 9.83% 3763 10357946 Ppp1r12b -0.2 0.8 7.8 1.72E-02 9.84% 3764 10589130 Celsr3 -0.2 0.8 5.7 1.72E-02 9.84% 3765 10598592 1700012L04Rik -0.2 0.8 5.6 1.72E-02 9.85% 3766 10366043 Dusp6 0.4 1.3 8.8 1.73E-02 9.87% 3767 10344210 -0.3 0.8 8.3 1.73E-02 9.87% 3768 10548735 Dusp16 -0.2 0.9 9.5 1.73E-02 9.87% 3769 10427334 Mir148b 0.3 1.2 4.9 1.73E-02 9.87% 3770 10496813 Ctbs 0.3 1.2 7.9 1.73E-02 9.87% 3771 10341024 -0.3 0.8 7.2 1.73E-02 9.87% 3772 10476775 Naa20 0.4 1.3 8.5 1.73E-02 9.87% 3773 10427691 Spef2 -0.3 0.8 4.3 1.73E-02 9.87% 3774 10545045 Fam13a -0.5 0.7 8.7 1.73E-02 9.87% 3775 10340990 0.2 1.2 12.8 1.73E-02 9.87% 3776 10424060 A930017M01Rik 0.4 1.3 5.5 1.73E-02 9.87% 3777 10561787 Zfp27 0.2 1.2 7.2 1.73E-02 9.87% 3778 10464572 Ndufv1 -0.3 0.8 10.5 1.74E-02 9.87% 3779 10552917 Rpl14 -0.2 0.9 6.1 1.74E-02 9.87% 3780 10339771 -0.6 0.7 5.0 1.74E-02 9.87% 3781 10405686 -0.3 0.8 5.1 1.74E-02 9.87% 3782 10341918 0.5 1.4 5.4 1.74E-02 9.87% 3783 10550574 Dmpk 0.2 1.2 8.9 1.74E-02 9.87% 3784 10568651 Dhx32 0.2 1.2 8.3 1.74E-02 9.87% 3785 10385699 Rmnd5b 0.3 1.2 8.8 1.74E-02 9.87% 3786 10447602 Ezr 0.3 1.2 7.6 1.74E-02 9.87% 3787 10420359 Gja3 -0.3 0.8 7.2 1.74E-02 9.88% 3788 10566599 Olfr699 -0.2 0.8 4.1 1.74E-02 9.88% 3789 10525452 Rnf34 0.2 1.2 7.5 1.74E-02 9.88% 3790 10392943 Hn1 0.3 1.2 8.1 1.74E-02 9.88% 3791 10369815 Cdk1 0.9 1.9 7.9 1.74E-02 9.88% 3792 10454353 Mocos 0.3 1.2 8.5 1.74E-02 9.89% 3793 10354247 Fhl2 -0.3 0.8 6.1 1.74E-02 9.89% 3794 10422537 Nalcn -0.2 0.9 5.7 1.74E-02 9.89% 3795 10414726 0.2 1.1 2.9 1.75E-02 9.90% 3796 10502565 Clca2 0.3 1.2 5.9 1.75E-02 9.90% 3797 10422280 Abcc4 0.5 1.4 7.7 1.75E-02 9.91% 3798 10448376 Flywch2 -0.2 0.9 6.4 1.75E-02 9.91% 3799 10491526 Acad9 0.2 1.1 9.7 1.75E-02 9.91% 3800 10471701 -0.2 0.9 6.4 1.75E-02 9.91% 3801 10519691 0.2 1.2 7.7 1.75E-02 9.91% 3802 10504757 BC005685 -0.2 0.8 5.2 1.75E-02 9.91%

Page 93 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3803 10554059 -0.3 0.8 5.2 1.75E-02 9.91% 3804 10582664 2310022B05Rik 0.2 1.1 8.2 1.76E-02 9.93% 3805 10587501 Rps27a 0.2 1.1 8.7 1.76E-02 9.93% 3806 10478580 Snx21 -0.2 0.9 7.3 1.76E-02 9.93% 3807 10403246 -0.4 0.8 7.4 1.76E-02 9.94% 3808 10419370 Exoc5 0.2 1.2 7.9 1.76E-02 9.94% 3809 10554081 Ttc23 -0.3 0.8 8.3 1.76E-02 9.94% 3810 10368907 Nr2e1 -0.2 0.8 5.5 1.76E-02 9.94% 3811 10598654 Gm14483 -0.2 0.9 5.8 1.76E-02 9.94% 3812 10383920 Nefh -0.2 0.9 6.5 1.76E-02 9.94% 3813 10550765 Vmn1r125 0.2 1.2 4.4 1.76E-02 9.94% 3814 10464450 -0.4 0.8 2.9 1.76E-02 9.94% 3815 10521111 Fgfr3 0.3 1.2 8.7 1.76E-02 9.94% 3816 10468419 Wdr96 -0.3 0.8 5.0 1.76E-02 9.95% 3817 10442087 Ncrna00085 -0.2 0.9 6.0 1.77E-02 9.95% 3818 10561831 Zfp566 0.3 1.2 6.6 1.77E-02 9.95% 3819 10339389 0.4 1.4 6.9 1.77E-02 9.95% 3820 10479945 Usp6nl -0.3 0.8 6.7 1.77E-02 9.95% 3821 10403420 Idi2 -0.2 0.9 3.8 1.77E-02 9.96% 3822 10395788 Srp54c 0.2 1.2 10.8 1.77E-02 9.96% 3823 10601091 Foxo4 -0.2 0.9 7.4 1.77E-02 9.96% 3824 10365242 Hcfc2 0.3 1.2 8.8 1.77E-02 9.97% 3825 10371111 Tjp3 0.3 1.3 7.7 1.77E-02 9.97% 3826 10342104 0.4 1.4 7.6 1.77E-02 9.97% 3827 10394938 -0.3 0.8 9.7 1.77E-02 9.97% 3828 10399657 -0.3 0.8 9.7 1.77E-02 9.97% 3829 10431792 Pus7l 0.3 1.2 6.8 1.77E-02 9.97% 3830 10505839 Klhl9 0.4 1.3 6.0 1.78E-02 9.97% 3831 10522217 Limch1 -0.2 0.9 5.5 1.78E-02 9.97% 3832 10399636 Mrto4 0.2 1.1 7.1 1.78E-02 9.97% 3833 10344083 0.2 1.2 10.6 1.78E-02 9.97% 3834 10567522 -0.2 0.8 6.6 1.78E-02 9.97% 3835 10532133 Evi5 -0.2 0.9 9.4 1.78E-02 9.97% 3836 10338847 0.3 1.2 9.8 1.78E-02 9.98% 3837 10457038 -0.2 0.9 7.1 1.78E-02 9.98% 3838 10442224 Zfp948 0.3 1.2 8.1 1.78E-02 9.98% 3839 10422500 Gm5089 -0.2 0.9 5.4 1.78E-02 9.98% 3840 10400210 Hectd1 -0.2 0.8 10.1 1.78E-02 9.98% 3841 10560304 Calm3 0.3 1.2 9.6 1.78E-02 9.98% 3842 10438959 Lsg1 0.2 1.2 8.9 1.78E-02 9.98% 3843 10462237 Smarca2 -0.3 0.8 10.4 1.78E-02 9.98%

Page 94 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3844 10338885 0.4 1.3 8.7 1.78E-02 9.99% 3845 10339921 -0.4 0.8 7.6 1.79E-02 9.99% 3846 10408042 Zkscan4 0.3 1.2 6.7 1.79E-02 9.99% 3847 10348087 Cops7b 0.2 1.2 8.4 1.79E-02 9.99% 3848 10526972 Nudt1 0.2 1.2 6.9 1.79E-02 10.01% 3849 10343289 -0.3 0.8 8.5 1.79E-02 10.01% 3850 10552681 Josd2 0.3 1.2 8.3 1.79E-02 10.01% 3851 10449284 Dusp1 -0.7 0.6 9.6 1.79E-02 10.01% 3852 10405552 Catsper3 -0.3 0.8 3.9 1.79E-02 10.01% 3853 10376986 Arhgap44 -0.2 0.9 6.1 1.79E-02 10.01% 3854 10564618 Fam174b -0.2 0.9 6.1 1.79E-02 10.01% 3855 10465734 AB056442 -0.4 0.8 9.0 1.79E-02 10.01% 3856 10601850 Bex4 -0.2 0.9 4.2 1.79E-02 10.01% 3857 10598089 0.3 1.2 11.6 1.79E-02 10.01% 3858 10445061 Rnf39 -0.3 0.8 8.1 1.80E-02 10.02% 3859 10565102 Ap3b2 -0.2 0.8 6.3 1.80E-02 10.02% 3860 10441556 Gm1604b -0.2 0.9 6.6 1.80E-02 10.02% 3861 10533261 Rph3a -0.2 0.9 6.7 1.80E-02 10.03% 3862 10456353 Grp -0.3 0.8 5.0 1.80E-02 10.03% 3863 10525887 Bri3bp -0.2 0.9 8.9 1.80E-02 10.03% 3864 10343040 -0.5 0.7 2.7 1.80E-02 10.03% 3865 10465965 4930579J09Rik -0.2 0.9 5.8 1.80E-02 10.03% 3866 10570397 Cdc16 0.2 1.2 8.1 1.80E-02 10.03% 3867 10558248 Bub3 0.2 1.2 9.1 1.80E-02 10.03% 3868 10573261 Asf1b 0.8 1.8 7.2 1.80E-02 10.03% 3869 10403945 Hist1h4m 0.4 1.3 6.4 1.80E-02 10.03% 3870 10347732 -0.3 0.8 6.5 1.81E-02 10.03% 3871 10607841 Tceanc -0.2 0.9 5.9 1.81E-02 10.04% 3872 10403982 Vmn1r188 0.2 1.1 3.1 1.81E-02 10.04% 3873 10512640 Gne -0.3 0.8 11.2 1.81E-02 10.04% 3874 10345879 Pou3f3 -0.3 0.8 6.8 1.81E-02 10.06% 3875 10579199 Slc25a42 -0.3 0.8 9.1 1.81E-02 10.06% 3876 10434629 Map3k13 -0.5 0.7 8.4 1.81E-02 10.06% 3877 10342774 -0.7 0.6 6.2 1.81E-02 10.06% 3878 10606215 Mir672 -0.2 0.9 4.0 1.82E-02 10.07% 3879 10532180 Cplx1 -0.2 0.8 6.3 1.82E-02 10.08% 3880 10365535 Tex18 0.2 1.2 3.8 1.82E-02 10.08% 3881 10603911 0.4 1.3 3.0 1.82E-02 10.08% 3882 10475879 -0.2 0.9 5.6 1.82E-02 10.08% 3883 10440849 Synj1 0.2 1.2 7.4 1.82E-02 10.08% 3884 10605143 Arhgap4 0.2 1.2 6.9 1.82E-02 10.08%

Page 95 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3885 10591622 Dock6 -0.2 0.9 8.0 1.82E-02 10.08% 3886 10607085 Kcne1l -0.2 0.9 5.5 1.82E-02 10.08% 3887 10340687 -0.4 0.8 4.7 1.82E-02 10.08% 3888 10358283 Crb1 -0.2 0.9 5.1 1.82E-02 10.08% 3889 10405427 Prelid1 0.1 1.1 12.2 1.82E-02 10.08% 3890 10392522 Abca8a -0.5 0.7 10.3 1.82E-02 10.08% 3891 10590918 Amotl1 -0.2 0.9 7.1 1.82E-02 10.08% 3892 10570201 Atp11a 0.6 1.6 7.4 1.83E-02 10.08% 3893 10604616 Plac1 -0.2 0.8 5.0 1.83E-02 10.08% 3894 10475578 Ctxn2 -0.2 0.9 4.2 1.83E-02 10.08% 3895 10594177 Tmem202 -0.3 0.8 3.9 1.83E-02 10.08% 3896 10565705 Omp -0.2 0.9 6.5 1.83E-02 10.08% 3897 10363112 Vgll2 -0.2 0.9 6.8 1.83E-02 10.10% 3898 10577114 Grtp1 -0.2 0.9 8.6 1.83E-02 10.12% 3899 10351504 0.3 1.2 4.3 1.83E-02 10.12% 3900 10343368 -0.6 0.6 4.5 1.83E-02 10.12% 3901 10352914 A330023F24Rik -0.3 0.8 6.8 1.84E-02 10.12% 3902 10346365 Sgol2 0.8 1.7 6.2 1.84E-02 10.12% 3903 10533991 0.4 1.3 7.4 1.84E-02 10.13% 3904 10371188 Celf5 -0.2 0.9 6.7 1.84E-02 10.14% 3905 10585588 Cspg4 -0.3 0.8 6.3 1.84E-02 10.15% 3906 10523506 Bmp3 -0.3 0.8 6.3 1.84E-02 10.15% 3907 10595909 0.4 1.3 7.7 1.84E-02 10.15% 3908 10550782 Vmn1r148 0.3 1.2 4.2 1.84E-02 10.15% 3909 10396442 Snapc1 0.2 1.2 6.6 1.84E-02 10.15% 3910 10397891 D230037D09Rik 0.3 1.3 6.2 1.85E-02 10.15% 3911 10580219 Calr 0.2 1.2 12.4 1.85E-02 10.15% 3912 10380761 Socs7 0.2 1.2 7.0 1.85E-02 10.16% 3913 10477475 Plunc -0.2 0.9 5.1 1.85E-02 10.16% 3914 10559200 Tnni2 -0.4 0.8 7.3 1.85E-02 10.16% 3915 10595171 E330016A19Rik 0.2 1.1 4.6 1.85E-02 10.16% 3916 10484791 Olfr1222 0.4 1.3 5.5 1.85E-02 10.16% 3917 10342862 -0.5 0.7 4.2 1.85E-02 10.16% 3918 10576940 Fam155a -0.3 0.8 6.0 1.85E-02 10.16% 3919 10532315 0.5 1.4 4.6 1.85E-02 10.16% 3920 10511062 Tmem52 -0.3 0.8 7.5 1.85E-02 10.16% 3921 10351043 Snord47 0.8 1.7 7.4 1.85E-02 10.16% 3922 10384223 Igfbp3 -0.3 0.8 9.2 1.85E-02 10.16% 3923 10596575 Manf 0.6 1.5 9.6 1.85E-02 10.16% 3924 10470392 Adamtsl2 -0.2 0.9 7.0 1.85E-02 10.16% 3925 10526213 -0.2 0.8 6.3 1.85E-02 10.16%

Page 96 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3926 10342250 0.8 1.7 3.7 1.86E-02 10.16% 3927 10532578 Myo18b -0.3 0.8 6.2 1.86E-02 10.19% 3928 10458355 Apbb3 -0.3 0.8 7.6 1.86E-02 10.19% 3929 10482273 Golga1 0.2 1.2 8.0 1.86E-02 10.19% 3930 10490028 Zfp64 0.2 1.1 7.5 1.86E-02 10.19% 3931 10384725 Rel 0.2 1.2 8.1 1.86E-02 10.19% 3932 10490611 Ptk6 0.3 1.2 6.2 1.86E-02 10.19% 3933 10466344 -0.3 0.8 5.7 1.86E-02 10.19% 3934 10339714 -0.3 0.8 2.7 1.86E-02 10.19% 3935 10344600 -0.5 0.7 6.4 1.86E-02 10.19% 3936 10462702 Hectd2 0.3 1.2 6.0 1.87E-02 10.20% 3937 10359982 Atf6 0.3 1.2 10.0 1.87E-02 10.21% 3938 10444800 Nhp2l1 0.3 1.2 10.2 1.87E-02 10.21% 3939 10471768 Olfr356 -0.3 0.8 4.7 1.87E-02 10.21% 3940 10341203 0.4 1.3 4.2 1.87E-02 10.21% 3941 10368277 Snora33 0.4 1.3 6.6 1.87E-02 10.22% 3942 10576027 -0.3 0.8 5.4 1.87E-02 10.22% 3943 10380403 Lrrc59 0.4 1.3 9.7 1.87E-02 10.22% 3944 10461583 Gpr44 -0.2 0.9 5.5 1.88E-02 10.23% 3945 10548097 9630033F20Rik 0.2 1.2 7.8 1.88E-02 10.23% 3946 10601880 BC065397 -0.2 0.9 6.4 1.88E-02 10.23% 3947 10366707 Avpr1a -0.4 0.7 8.5 1.88E-02 10.23% 3948 10386368 2310033P09Rik -0.2 0.9 6.1 1.88E-02 10.23% 3949 10380887 Tcap -0.3 0.8 6.0 1.88E-02 10.23% 3950 10597136 Ptpn23 0.1 1.1 7.2 1.88E-02 10.23% 3951 10338200 0.6 1.5 6.6 1.88E-02 10.23% 3952 10405969 -0.2 0.9 9.1 1.88E-02 10.23% 3953 10409214 Mir683-1 -0.2 0.9 3.7 1.88E-02 10.23% 3954 10409216 Mir683-1 -0.2 0.9 3.7 1.88E-02 10.23% 3955 10528077 Dbf4 0.6 1.5 6.3 1.88E-02 10.24% 3956 10411711 Cdk7 0.3 1.2 7.7 1.88E-02 10.24% 3957 10461156 Snhg1 0.9 1.9 7.7 1.88E-02 10.24% 3958 10343053 0.5 1.4 3.7 1.88E-02 10.24% 3959 10412897 -0.3 0.8 7.6 1.88E-02 10.24% 3960 10350668 Glt25d2 0.5 1.4 6.5 1.88E-02 10.24% 3961 10434559 Ephb3 -0.2 0.9 6.0 1.89E-02 10.25% 3962 10460376 Ppp1ca 0.2 1.2 10.6 1.89E-02 10.25% 3963 10352918 Mir29c -0.4 0.8 5.7 1.89E-02 10.25% 3964 10339733 0.5 1.4 5.7 1.89E-02 10.25% 3965 10424676 Ly6e 0.4 1.3 11.8 1.89E-02 10.25% 3966 10403003 -0.2 0.9 4.2 1.89E-02 10.25%

Page 97 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

3967 10342436 0.3 1.3 10.2 1.89E-02 10.25% 3968 10483871 Ttn -0.7 0.6 5.9 1.89E-02 10.25% 3969 10435724 B4galt4 0.2 1.1 6.2 1.89E-02 10.25% 3970 10401002 Gphb5 -0.2 0.9 5.4 1.89E-02 10.25% 3971 10413813 Galntl2 -0.2 0.8 6.4 1.89E-02 10.26% 3972 10372235 Ptprq -0.2 0.9 5.7 1.90E-02 10.27% 3973 10532072 Hfm1 0.2 1.2 3.3 1.90E-02 10.27% 3974 10538873 0.2 1.2 3.7 1.90E-02 10.27% 3975 10512728 Tstd2 0.2 1.1 8.4 1.90E-02 10.27% 3976 10344000 0.9 1.9 5.0 1.90E-02 10.27% 3977 10429972 Cpsf1 0.2 1.1 8.1 1.90E-02 10.27% 3978 10354868 Fam126b -0.4 0.8 9.2 1.90E-02 10.28% 3979 10500804 LOC269472 -0.2 0.8 5.0 1.90E-02 10.28% 3980 10340898 -0.3 0.8 9.1 1.90E-02 10.28% 3981 10512499 Tpm2 -0.5 0.7 6.0 1.90E-02 10.28% 3982 10339486 0.8 1.7 5.7 1.91E-02 10.29% 3983 10567750 Gtf3c1 0.2 1.2 8.8 1.91E-02 10.29% 3984 10577948 Brf2 0.2 1.2 6.6 1.91E-02 10.29% 3985 10485514 Caprin1 0.2 1.2 11.2 1.91E-02 10.29% 3986 10470768 Urm1 0.2 1.1 7.6 1.91E-02 10.29% 3987 10439612 Boc -0.2 0.8 6.1 1.91E-02 10.30% 3988 10400072 Scin -0.2 0.9 4.8 1.91E-02 10.30% 3989 10359422 Prdx6 -0.2 0.9 11.7 1.91E-02 10.30% 3990 10502686 Dnase2b -0.2 0.8 9.5 1.91E-02 10.30% 3991 10347307 Gpbar1 -0.2 0.9 6.7 1.91E-02 10.30% 3992 10599300 Rhox7 -0.2 0.9 6.2 1.91E-02 10.30% 3993 10358457 Bex4 -0.3 0.8 3.9 1.91E-02 10.30% 3994 10381211 Naglu -0.2 0.8 8.1 1.91E-02 10.30% 3995 10498800 Ube2d2 0.2 1.1 10.5 1.91E-02 10.30% 3996 10465742 Gm5631 0.2 1.2 11.3 1.91E-02 10.30% 3997 10521467 Ccdc96 -0.3 0.8 5.5 1.91E-02 10.30% 3998 10432866 Krt77 -0.2 0.8 6.0 1.91E-02 10.30% 3999 10375677 Mir340 0.4 1.3 4.1 1.92E-02 10.30% 4000 10600726 Mageb1 -0.2 0.9 4.8 1.92E-02 10.30% 4001 10605664 Mageb1 -0.2 0.9 4.8 1.92E-02 10.30% 4002 10587621 Ripply2 -0.2 0.9 5.5 1.92E-02 10.30% 4003 10364222 Ftcd -0.3 0.8 10.8 1.92E-02 10.30% 4004 10339485 0.7 1.6 5.6 1.92E-02 10.30% 4005 10339135 0.7 1.6 4.9 1.92E-02 10.31% 4006 10574456 Cklf 0.2 1.2 6.0 1.92E-02 10.31% 4007 10340851 -0.5 0.7 8.8 1.92E-02 10.32%

Page 98 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4008 10342246 0.4 1.3 8.0 1.92E-02 10.33% 4009 10344340 0.9 1.8 3.7 1.92E-02 10.33% 4010 10482920 Cd302 0.2 1.1 11.4 1.93E-02 10.33% 4011 10548563 Ptp4a1 -0.3 0.8 11.8 1.93E-02 10.33% 4012 10375751 Adamts2 -0.2 0.9 7.3 1.93E-02 10.33% 4013 10526832 0.3 1.2 6.1 1.93E-02 10.34% 4014 10553199 Otog -0.2 0.9 5.5 1.93E-02 10.35% 4015 10460112 -0.2 0.9 4.5 1.93E-02 10.35% 4016 10523134 Pf4 0.2 1.2 6.4 1.93E-02 10.35% 4017 10480317 H2afb1 -0.2 0.8 7.0 1.94E-02 10.36% 4018 10362464 Sult3a1 0.2 1.1 12.6 1.94E-02 10.36% 4019 10551534 Fbxo27 -0.3 0.8 6.3 1.94E-02 10.36% 4020 10492590 Ppm1l 0.2 1.2 8.0 1.94E-02 10.36% 4021 10569545 Nadsyn1 -0.2 0.9 7.8 1.94E-02 10.36% 4022 10436304 Abi3bp -0.3 0.8 7.4 1.94E-02 10.36% 4023 10359582 Fmo2 -0.5 0.7 9.0 1.94E-02 10.36% 4024 10608371 0.2 1.2 3.4 1.94E-02 10.37% 4025 10396877 Galntl1 -0.2 0.9 5.8 1.94E-02 10.37% 4026 10573266 Prkaca 0.2 1.2 8.3 1.94E-02 10.38% 4027 10456793 Ier3ip1 0.2 1.2 8.1 1.94E-02 10.38% 4028 10342632 0.2 1.2 8.3 1.94E-02 10.38% 4029 10477854 Epb4.1l1 -0.2 0.9 6.5 1.94E-02 10.38% 4030 10545804 Gm5878 -0.2 0.9 5.7 1.95E-02 10.38% 4031 10535247 Iqce 0.2 1.1 6.8 1.95E-02 10.40% 4032 10376414 Olfr313 -0.2 0.9 4.6 1.95E-02 10.41% 4033 10541910 Vwf -0.3 0.8 7.1 1.95E-02 10.41% 4034 10462346 Rcl1 -0.3 0.8 9.8 1.95E-02 10.41% 4035 10515803 Wdr65 -0.3 0.8 5.9 1.95E-02 10.41% 4036 10462005 Tmem2 -0.2 0.9 8.1 1.95E-02 10.41% 4037 10338682 0.7 1.7 5.0 1.96E-02 10.42% 4038 10386633 Gm16516 0.2 1.2 6.5 1.96E-02 10.42% 4039 10501860 Fnbp1l 0.3 1.3 8.1 1.96E-02 10.42% 4040 10353036 -0.3 0.8 7.1 1.96E-02 10.42% 4041 10490923 Car2 0.4 1.3 8.6 1.96E-02 10.42% 4042 10389797 Stxbp4 0.2 1.2 6.7 1.96E-02 10.43% 4043 10417273 Esd 0.2 1.2 11.0 1.96E-02 10.43% 4044 10340036 0.3 1.3 7.7 1.96E-02 10.43% 4045 10519983 Fgl2 0.4 1.3 6.5 1.96E-02 10.43% 4046 10437575 Tmem114 -0.3 0.8 5.5 1.96E-02 10.43% 4047 10566097 Nup98 0.2 1.1 9.1 1.96E-02 10.43% 4048 10341657 0.2 1.2 10.4 1.96E-02 10.43%

Page 99 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4049 10448402 Prss30 -0.2 0.8 5.4 1.96E-02 10.43% 4050 10396795 Eif2s1 0.2 1.2 9.9 1.97E-02 10.44% 4051 10356932 D1Ertd622e 0.3 1.2 8.6 1.97E-02 10.45% 4052 10444578 Neu1 0.2 1.2 8.6 1.97E-02 10.45% 4053 10550978 Phldb3 -0.2 0.9 7.4 1.97E-02 10.45% 4054 10495343 Wdr47 0.3 1.2 5.7 1.97E-02 10.45% 4055 10435185 0.6 1.5 7.5 1.97E-02 10.45% 4056 10367973 Aig1 0.2 1.2 8.5 1.97E-02 10.45% 4057 10342633 -0.3 0.8 4.9 1.97E-02 10.46% 4058 10584187 St3gal4 0.2 1.2 7.9 1.97E-02 10.46% 4059 10423803 -0.4 0.8 6.8 1.97E-02 10.46% 4060 10503615 -0.2 0.8 7.5 1.97E-02 10.46% 4061 10411899 2410002O22Rik 0.3 1.2 9.0 1.98E-02 10.46% 4062 10480459 Hnmt 0.3 1.2 8.5 1.98E-02 10.46% 4063 10338827 -0.4 0.8 6.0 1.98E-02 10.46% 4064 10558533 0.2 1.1 11.1 1.98E-02 10.46% 4065 10356484 Gbx2 -0.3 0.8 6.4 1.98E-02 10.46% 4066 10560719 2210010C17Rik -0.2 0.9 5.5 1.98E-02 10.46% 4067 10393045 Itgb4 -0.2 0.9 6.7 1.98E-02 10.46% 4068 10467529 Opalin -0.2 0.9 4.5 1.98E-02 10.47% 4069 10493267 Arhgef2 0.2 1.1 6.8 1.98E-02 10.47% 4070 10504375 Npr2 -0.4 0.7 8.6 1.98E-02 10.47% 4071 10497842 Bbs7 0.3 1.2 7.5 1.98E-02 10.47% 4072 10506335 Pde4b 0.4 1.3 7.2 1.98E-02 10.47% 4073 10379184 Slc46a1 -0.2 0.9 9.1 1.98E-02 10.47% 4074 10505254 -0.3 0.8 11.1 1.98E-02 10.48% 4075 10400975 Trmt5 0.3 1.3 7.7 1.99E-02 10.49% 4076 10552812 Irf3 0.2 1.1 8.5 1.99E-02 10.49% 4077 10469018 -0.3 0.8 5.0 1.99E-02 10.49% 4078 10376074 P4ha2 -0.3 0.8 6.1 1.99E-02 10.49% 4079 10558795 Pkp3 -0.2 0.8 6.6 1.99E-02 10.50% 4080 10342391 -0.3 0.8 3.7 1.99E-02 10.50% 4081 10344604 0.3 1.2 9.9 2.00E-02 10.53% 4082 10360235 Casq1 -0.6 0.7 5.7 2.00E-02 10.53% 4083 10368730 Rpf2 0.4 1.3 6.5 2.00E-02 10.53% 4084 10361651 Nup43 0.3 1.3 6.9 2.00E-02 10.53% 4085 10545917 Pcbp1 0.2 1.2 10.4 2.00E-02 10.55% 4086 10450819 Znrd1 0.3 1.2 7.8 2.01E-02 10.55% 4087 10541683 C1rb -0.2 0.9 11.0 2.01E-02 10.55% 4088 10339599 -0.3 0.8 9.0 2.01E-02 10.55% 4089 10393573 Lgals3bp 0.3 1.3 9.3 2.01E-02 10.55%

Page 100 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4090 10416169 Gnrh1 -0.3 0.8 6.3 2.01E-02 10.55% 4091 10593413 2310030G06Rik 0.2 1.2 8.1 2.01E-02 10.56% 4092 10599855 Eif4e 0.3 1.3 9.0 2.01E-02 10.56% 4093 10490872 Lrrcc1 0.3 1.3 5.6 2.01E-02 10.57% 4094 10459335 Fam38b -0.2 0.9 5.9 2.01E-02 10.58% 4095 10534140 0610007L01Rik -0.2 0.8 7.1 2.01E-02 10.58% 4096 10375543 Olfr1393 -0.3 0.8 6.5 2.02E-02 10.58% 4097 10339642 -0.3 0.8 9.7 2.02E-02 10.58% 4098 10520355 Htr5a -0.3 0.8 5.7 2.02E-02 10.58% 4099 10355763 Atg9a -0.2 0.9 9.0 2.02E-02 10.58% 4100 10401987 Kcnk10 -0.2 0.9 5.9 2.02E-02 10.58% 4101 10461898 Rfk 0.2 1.1 10.5 2.02E-02 10.59% 4102 10479351 Adrm1 0.2 1.1 9.3 2.02E-02 10.59% 4103 10368484 -0.2 0.9 4.4 2.02E-02 10.59% 4104 10414355 Mapk1ip1l 0.2 1.1 10.8 2.02E-02 10.59% 4105 10396175 -0.2 0.8 5.6 2.02E-02 10.59% 4106 10477986 Nnat -0.2 0.9 6.0 2.02E-02 10.59% 4107 10590149 Xylb -0.2 0.9 10.5 2.02E-02 10.59% 4108 10568318 Prss53 -0.2 0.9 7.2 2.02E-02 10.59% 4109 10370422 Pwp2 0.2 1.2 7.4 2.02E-02 10.60% 4110 10554392 D330012F22Rik 0.3 1.2 7.8 2.03E-02 10.60% 4111 10603926 Gm10058 0.4 1.3 4.5 2.03E-02 10.60% 4112 10411527 Cartpt -0.2 0.8 6.1 2.03E-02 10.60% 4113 10448803 Hn1l 0.3 1.3 9.5 2.03E-02 10.60% 4114 10344140 -0.5 0.7 5.0 2.03E-02 10.60% 4115 10560030 Vmn2r56 -0.3 0.8 4.1 2.03E-02 10.60% 4116 10339821 -0.4 0.7 6.8 2.03E-02 10.61% 4117 10339634 0.5 1.4 5.7 2.03E-02 10.61% 4118 10489355 -0.2 0.9 6.6 2.03E-02 10.61% 4119 10592289 Ccdc15 -0.3 0.8 5.4 2.03E-02 10.62% 4120 10438907 Gp5 -0.3 0.8 6.3 2.04E-02 10.63% 4121 10529953 Gm10048 -0.3 0.8 5.0 2.04E-02 10.63% 4122 10559987 Mir297-1 0.1 1.1 2.2 2.04E-02 10.63% 4123 10413377 -0.2 0.9 6.2 2.04E-02 10.63% 4124 10535841 Slc46a3 -0.3 0.8 10.8 2.04E-02 10.63% 4125 10394040 Csnk1d -0.1 0.9 9.7 2.04E-02 10.63% 4126 10515960 Kcnq4 -0.2 0.9 5.9 2.04E-02 10.63% 4127 10533145 Tpcn1 -0.3 0.8 9.1 2.04E-02 10.63% 4128 10375732 -0.2 0.9 8.2 2.04E-02 10.63% 4129 10585803 Stra6 -0.2 0.9 6.6 2.04E-02 10.63% 4130 10558515 Inpp5a 0.2 1.1 8.3 2.04E-02 10.64%

Page 101 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4131 10564023 0.3 1.3 3.1 2.04E-02 10.64% 4132 10382096 2310007L24Rik -0.2 0.8 7.0 2.04E-02 10.64% 4133 10536079 Gprc2a-rs5 -0.2 0.8 4.6 2.05E-02 10.64% 4134 10552331 Gprc2a-rs5 -0.2 0.8 4.6 2.05E-02 10.64% 4135 10468802 D19Ertd737e 0.2 1.2 6.9 2.05E-02 10.65% 4136 10383200 0.3 1.2 7.9 2.05E-02 10.65% 4137 10443786 Pde9a 0.5 1.4 9.0 2.05E-02 10.65% 4138 10608702 C86695 -0.3 0.8 6.4 2.05E-02 10.65% 4139 10438094 Mir130b -0.2 0.9 5.6 2.05E-02 10.65% 4140 10607398 -0.2 0.8 7.1 2.05E-02 10.65% 4141 10528679 Wdr86 -0.2 0.9 6.4 2.05E-02 10.66% 4142 10356681 Otos -0.3 0.8 5.8 2.06E-02 10.67% 4143 10551531 Sycn -0.2 0.8 6.5 2.06E-02 10.68% 4144 10374083 Aebp1 -0.3 0.8 6.5 2.06E-02 10.69% 4145 10514128 Ttc39b 0.4 1.3 9.2 2.06E-02 10.70% 4146 10594199 Thsd4 -0.2 0.9 6.0 2.06E-02 10.70% 4147 10532085 Tgfbr3 -0.2 0.9 7.5 2.07E-02 10.71% 4148 10576124 Ctu2 0.2 1.1 7.1 2.07E-02 10.71% 4149 10389526 Cltc 0.2 1.1 11.3 2.07E-02 10.73% 4150 10339130 -0.6 0.7 4.3 2.07E-02 10.73% 4151 10457400 0.2 1.2 8.0 2.07E-02 10.73% 4152 10376889 Mmgt2 0.4 1.3 7.1 2.07E-02 10.73% 4153 10565935 Arhgef17 -0.1 0.9 6.7 2.07E-02 10.73% 4154 10497214 Tpd52 0.3 1.2 5.4 2.07E-02 10.73% 4155 10414137 Grid1 -0.3 0.8 6.4 2.07E-02 10.73% 4156 10418434 Itih3 0.3 1.2 12.5 2.08E-02 10.74% 4157 10343967 -0.4 0.7 5.3 2.08E-02 10.74% 4158 10356248 C130026I21Rik 0.2 1.2 5.6 2.08E-02 10.75% 4159 10521755 4930449I04Rik -0.3 0.8 7.2 2.08E-02 10.75% 4160 10518228 Vps13d -0.2 0.9 9.4 2.08E-02 10.75% 4161 10468070 Fgf8 -0.2 0.9 7.3 2.08E-02 10.75% 4162 10591618 Dock6 -0.2 0.9 7.5 2.08E-02 10.75% 4163 10339487 0.4 1.3 2.4 2.08E-02 10.75% 4164 10532596 Myo18b -0.3 0.8 5.6 2.08E-02 10.75% 4165 10520304 Actr3b -0.2 0.9 4.4 2.08E-02 10.75% 4166 10345032 Il17a -0.2 0.9 5.8 2.08E-02 10.75% 4167 10364112 Gm5134 -0.2 0.9 5.4 2.08E-02 10.75% 4168 10347697 Slc4a3 -0.2 0.9 6.4 2.08E-02 10.75% 4169 10580365 4921524J17Rik 0.2 1.2 7.6 2.08E-02 10.75% 4170 10608659 Klra22 0.2 1.2 2.5 2.08E-02 10.75% 4171 10454326 2700062C07Rik 0.2 1.1 7.6 2.09E-02 10.76%

Page 102 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4172 10591620 Dock6 -0.2 0.9 7.3 2.09E-02 10.76% 4173 10604564 Gpc4 -0.2 0.9 10.0 2.09E-02 10.76% 4174 10344219 -0.6 0.7 6.1 2.09E-02 10.76% 4175 10537343 Tmem213 -0.3 0.8 7.3 2.09E-02 10.77% 4176 10398451 Rps25 0.2 1.1 10.5 2.09E-02 10.77% 4177 10343878 -0.4 0.8 6.7 2.09E-02 10.77% 4178 10562394 -0.2 0.8 5.4 2.09E-02 10.77% 4179 10338832 0.2 1.2 7.4 2.10E-02 10.79% 4180 10341144 -0.5 0.7 6.2 2.10E-02 10.80% 4181 10491056 Tbl1xr1 -0.4 0.8 9.0 2.10E-02 10.81% 4182 10481560 Qrfp -0.2 0.8 6.5 2.10E-02 10.81% 4183 10413014 Chchd1 0.2 1.2 8.5 2.10E-02 10.81% 4184 10349239 Mki67ip 0.3 1.2 9.8 2.10E-02 10.81% 4185 10585146 Tmprss5 -0.2 0.9 5.9 2.10E-02 10.81% 4186 10549506 Dennd5b -0.2 0.9 10.0 2.10E-02 10.81% 4187 10608394 Srsy 0.1 1.1 3.1 2.11E-02 10.81% 4188 10490551 Nkain4 -0.3 0.8 6.4 2.11E-02 10.82% 4189 10505000 Nipsnap3b 0.2 1.1 9.3 2.11E-02 10.82% 4190 10554057 Adamts17 -0.2 0.9 8.1 2.11E-02 10.82% 4191 10365845 Fgd6 -0.3 0.8 8.3 2.11E-02 10.82% 4192 10543306 Tspan12 -0.2 0.8 10.4 2.11E-02 10.82% 4193 10340323 0.4 1.4 3.3 2.11E-02 10.82% 4194 10434741 0.3 1.3 5.0 2.11E-02 10.82% 4195 10338849 0.5 1.4 5.3 2.11E-02 10.82% 4196 10344196 0.5 1.4 3.4 2.11E-02 10.82% 4197 10583286 Gpr83 -0.2 0.9 6.1 2.11E-02 10.83% 4198 10404264 Prl -0.2 0.8 4.5 2.11E-02 10.83% 4199 10465224 -0.2 0.9 5.2 2.12E-02 10.85% 4200 10601537 0.3 1.2 6.7 2.12E-02 10.85% 4201 10341932 1.0 2.0 3.4 2.12E-02 10.85% 4202 10505556 Gm428 -0.2 0.9 5.2 2.12E-02 10.85% 4203 10399823 0.4 1.3 6.6 2.12E-02 10.85% 4204 10471608 Cep110 0.2 1.1 7.6 2.12E-02 10.85% 4205 10550698 Ckm -0.7 0.6 6.9 2.12E-02 10.85% 4206 10591090 Fat3 -0.2 0.9 6.3 2.12E-02 10.85% 4207 10384717 Pex13 0.2 1.2 9.5 2.12E-02 10.85% 4208 10592416 Olfr959 -0.2 0.9 5.3 2.12E-02 10.85% 4209 10444656 -0.2 0.9 4.0 2.13E-02 10.86% 4210 10439237 Rps21 0.3 1.2 6.3 2.13E-02 10.87% 4211 10566417 Olfr675 -0.2 0.8 3.6 2.13E-02 10.87% 4212 10442549 Zfp598 0.2 1.1 7.9 2.13E-02 10.87%

Page 103 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4213 10345552 -0.2 0.9 7.6 2.13E-02 10.87% 4214 10582978 8430410K20Rik 0.3 1.2 7.9 2.13E-02 10.87% 4215 10460829 Mir194-2 -0.2 0.8 6.4 2.13E-02 10.87% 4216 10506781 2010305A19Rik 0.3 1.2 8.5 2.13E-02 10.88% 4217 10554549 Whamm -0.3 0.8 8.8 2.13E-02 10.88% 4218 10340865 0.5 1.4 4.4 2.13E-02 10.88% 4219 10351111 Dnm3os -0.2 0.9 5.1 2.14E-02 10.89% 4220 10556035 Olfr713 -0.2 0.9 5.3 2.14E-02 10.89% 4221 10349634 0.7 1.6 5.1 2.14E-02 10.89% 4222 10554397 Ttll13 -0.2 0.9 6.2 2.14E-02 10.89% 4223 10474825 D2Ertd750e 0.7 1.6 7.1 2.14E-02 10.89% 4224 10442357 Prss32 -0.3 0.8 6.2 2.14E-02 10.89% 4225 10359970 Nos1ap 0.5 1.4 7.7 2.14E-02 10.89% 4226 10339753 0.5 1.4 8.4 2.14E-02 10.91% 4227 10560744 Vmn1r117 0.3 1.2 3.6 2.15E-02 10.92% 4228 10356508 -0.2 0.8 4.4 2.15E-02 10.93% 4229 10401023 Wdr89 -0.2 0.9 6.8 2.15E-02 10.93% 4230 10461354 Tut1 0.2 1.2 7.6 2.15E-02 10.93% 4231 10414163 Lrit1 -0.3 0.8 7.5 2.15E-02 10.94% 4232 10352166 Cnst -0.3 0.8 7.5 2.15E-02 10.94% 4233 10348917 Fam174a 0.4 1.3 7.8 2.15E-02 10.95% 4234 10565607 -0.2 0.9 6.0 2.16E-02 10.95% 4235 10437364 Adcy9 -0.3 0.8 8.1 2.16E-02 10.95% 4236 10499941 Kprp -0.2 0.9 5.2 2.16E-02 10.95% 4237 10450451 Prrc2a 0.2 1.2 8.6 2.16E-02 10.97% 4238 10407255 Gm6320 -0.2 0.8 6.5 2.16E-02 10.97% 4239 10344273 0.6 1.5 6.1 2.16E-02 10.97% 4240 10592493 4931429I11Rik -0.2 0.9 5.7 2.16E-02 10.97% 4241 10499896 Sprr3 -0.2 0.9 5.0 2.16E-02 10.97% 4242 10355528 Tns1 -0.4 0.8 8.4 2.16E-02 10.97% 4243 10426169 1300018J18Rik -0.2 0.9 9.5 2.17E-02 10.97% 4244 10519669 Gm8912 0.2 1.2 8.4 2.17E-02 10.97% 4245 10447286 Rpl31 0.2 1.1 9.7 2.17E-02 10.99% 4246 10341858 0.6 1.5 2.9 2.17E-02 10.99% 4247 10575894 Lrrc50 -0.3 0.8 6.3 2.17E-02 10.99% 4248 10532150 Fam69a -0.3 0.8 8.3 2.17E-02 11.00% 4249 10458386 Ndufa2 0.2 1.2 9.4 2.17E-02 11.01% 4250 10583834 Anln -0.2 0.9 5.3 2.17E-02 11.01% 4251 10519181 -0.3 0.8 7.2 2.18E-02 11.01% 4252 10384797 Ccdc85a -0.2 0.9 5.1 2.18E-02 11.01% 4253 10408935 -0.6 0.7 8.9 2.18E-02 11.01%

Page 104 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4254 10467372 Cyp2c38 -0.3 0.8 10.6 2.18E-02 11.01% 4255 10592816 Hmbs 0.2 1.1 9.9 2.18E-02 11.01% 4256 10424062 A930017M01Rik 0.3 1.2 6.3 2.18E-02 11.01% 4257 10342826 -0.3 0.8 5.8 2.18E-02 11.03% 4258 10580522 Tox3 -0.2 0.9 5.8 2.19E-02 11.05% 4259 10452721 Trmt61b 0.2 1.2 6.6 2.19E-02 11.05% 4260 10464877 Dpp3 0.2 1.1 8.8 2.19E-02 11.06% 4261 10542745 Fgfr1op2 0.2 1.2 8.7 2.19E-02 11.06% 4262 10344071 -0.2 0.9 9.5 2.19E-02 11.07% 4263 10583920 Eepd1 0.2 1.2 8.1 2.20E-02 11.09% 4264 10596383 Col6a6 -0.2 0.9 7.3 2.20E-02 11.10% 4265 10447708 Qk -0.1 0.9 9.9 2.20E-02 11.10% 4266 10532598 Myo18b -0.2 0.9 6.2 2.20E-02 11.10% 4267 10367507 Olfr792 -0.4 0.8 3.9 2.20E-02 11.11% 4268 10400989 Kcnh5 -0.2 0.9 5.4 2.20E-02 11.11% 4269 10603354 Magix -0.2 0.9 6.8 2.20E-02 11.11% 4270 10487890 Erv3 0.7 1.7 6.5 2.20E-02 11.11% 4271 10341876 -0.5 0.7 6.8 2.21E-02 11.11% 4272 10375774 Grm6 -0.1 0.9 5.8 2.21E-02 11.11% 4273 10452485 Rab31 0.3 1.2 7.7 2.21E-02 11.11% 4274 10340443 0.6 1.5 7.8 2.21E-02 11.11% 4275 10339687 -0.7 0.6 6.8 2.21E-02 11.12% 4276 10564272 Chrna7 -0.2 0.9 5.8 2.21E-02 11.13% 4277 10393687 Azi1 -0.2 0.9 6.8 2.21E-02 11.13% 4278 10466008 Dak 0.3 1.3 10.6 2.21E-02 11.14% 4279 10343984 -0.4 0.8 6.3 2.22E-02 11.14% 4280 10581491 -0.2 0.9 6.8 2.22E-02 11.14% 4281 10399232 -0.2 0.8 6.2 2.22E-02 11.14% 4282 10413136 0.2 1.1 2.5 2.22E-02 11.14% 4283 10343405 0.5 1.4 8.8 2.22E-02 11.15% 4284 10527012 Lfng 0.2 1.2 6.9 2.22E-02 11.15% 4285 10339500 0.2 1.2 9.2 2.22E-02 11.15% 4286 10340989 0.5 1.4 9.1 2.22E-02 11.15% 4287 10572932 Naa20 0.3 1.3 8.9 2.22E-02 11.15% 4288 10567072 Psma1 0.2 1.2 10.5 2.22E-02 11.15% 4289 10377508 Trappc1 0.2 1.2 9.9 2.23E-02 11.16% 4290 10445558 BC048355 -0.3 0.8 8.0 2.23E-02 11.16% 4291 10435543 Golgb1 0.3 1.2 8.2 2.23E-02 11.16% 4292 10561994 Lin37 0.2 1.1 7.7 2.23E-02 11.16% 4293 10490559 Chrna4 -0.5 0.7 6.7 2.23E-02 11.17% 4294 10379989 Fam33a 0.4 1.3 7.4 2.23E-02 11.17%

Page 105 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4295 10567084 -0.2 0.9 6.8 2.23E-02 11.17% 4296 10481182 Fam163b -0.3 0.8 6.5 2.23E-02 11.17% 4297 10355259 Myl1 -1.5 0.4 4.3 2.23E-02 11.18% 4298 10582925 Alkbh8 0.3 1.2 7.8 2.23E-02 11.18% 4299 10516658 Ccdc28b -0.2 0.9 6.3 2.23E-02 11.18% 4300 10574384 Ndrg4 -0.2 0.9 5.8 2.23E-02 11.18% 4301 10483178 Cobll1 -0.2 0.8 9.2 2.24E-02 11.18% 4302 10343396 -0.3 0.8 10.6 2.24E-02 11.20% 4303 10599092 0.3 1.2 5.7 2.24E-02 11.20% 4304 10564033 0.3 1.2 3.1 2.24E-02 11.20% 4305 10474381 Kif18a 0.4 1.3 5.2 2.24E-02 11.21% 4306 10395628 Scfd1 0.4 1.3 9.3 2.24E-02 11.21% 4307 10608667 Myef2 0.5 1.4 7.2 2.24E-02 11.21% 4308 10364766 Rps15 0.1 1.1 11.4 2.24E-02 11.21% 4309 10593492 Zc3h12c -0.2 0.9 8.3 2.25E-02 11.21% 4310 10582201 Cox4nb 0.2 1.1 8.0 2.25E-02 11.22% 4311 10444756 Atp6v1g2 -0.3 0.8 7.6 2.25E-02 11.23% 4312 10342139 0.6 1.5 4.2 2.25E-02 11.23% 4313 10427997 Ankrd33b -0.3 0.8 7.3 2.25E-02 11.23% 4314 10462863 0.3 1.2 3.5 2.25E-02 11.23% 4315 10502214 Cyp2u1 -0.3 0.8 7.8 2.25E-02 11.23% 4316 10465831 5730408K05Rik 0.3 1.2 7.9 2.25E-02 11.23% 4317 10343759 -0.3 0.8 2.5 2.25E-02 11.23% 4318 10339259 0.5 1.4 5.5 2.25E-02 11.23% 4319 10340117 -0.4 0.8 6.6 2.25E-02 11.23% 4320 10515716 Szt2 0.2 1.1 6.9 2.25E-02 11.23% 4321 10473312 Fam171b 0.4 1.3 6.1 2.26E-02 11.23% 4322 10342920 -0.3 0.8 7.2 2.26E-02 11.23% 4323 10544815 Hibadh -0.2 0.9 12.4 2.26E-02 11.24% 4324 10519686 Gm8944 0.2 1.1 7.6 2.26E-02 11.24% 4325 10490384 Lama5 -0.1 0.9 6.5 2.26E-02 11.24% 4326 10538963 Rpl34 0.1 1.1 11.8 2.26E-02 11.24% 4327 10449071 Rhot2 -0.2 0.9 7.8 2.26E-02 11.24% 4328 10451472 Rpl7l1 0.2 1.2 9.9 2.26E-02 11.25% 4329 10416680 Pcdh8 -0.2 0.8 5.4 2.26E-02 11.25% 4330 10476590 Macrod2 -0.3 0.8 6.7 2.26E-02 11.25% 4331 10444098 Wdr46 -0.2 0.9 8.5 2.27E-02 11.25% 4332 10523245 Fam47e 0.5 1.5 9.1 2.27E-02 11.25% 4333 10508019 Gnl2 0.3 1.2 8.6 2.27E-02 11.26% 4334 10516229 Utp11l 0.3 1.2 8.1 2.27E-02 11.26% 4335 10341450 -0.2 0.9 11.6 2.27E-02 11.26%

Page 106 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4336 10339313 0.4 1.3 2.5 2.27E-02 11.26% 4337 10528544 Rpl11 0.2 1.1 9.7 2.27E-02 11.26% 4338 10343387 0.5 1.4 7.0 2.27E-02 11.26% 4339 10462091 Klf9 -0.5 0.7 9.5 2.27E-02 11.26% 4340 10394018 Ccdc57 -0.2 0.9 6.5 2.27E-02 11.26% 4341 10499113 Prss48 -0.2 0.9 6.1 2.27E-02 11.26% 4342 10465633 Cox8a -0.2 0.9 11.3 2.27E-02 11.26% 4343 10342688 -0.5 0.7 3.7 2.27E-02 11.26% 4344 10591632 Dock6 -0.2 0.9 6.8 2.27E-02 11.26% 4345 10538842 Gng12 -0.1 0.9 11.0 2.28E-02 11.26% 4346 10578582 D030016E14Rik 0.2 1.1 8.7 2.28E-02 11.26% 4347 10554351 Wdr93 -0.3 0.8 5.6 2.28E-02 11.28% 4348 10339390 -0.2 0.9 8.9 2.28E-02 11.29% 4349 10340660 0.6 1.5 4.4 2.28E-02 11.29% 4350 10569870 Retn -0.3 0.8 6.2 2.28E-02 11.30% 4351 10339041 -0.6 0.7 6.9 2.29E-02 11.30% 4352 10473406 Prg3 -0.3 0.8 5.8 2.29E-02 11.30% 4353 10559558 Tnni3 -0.2 0.9 5.8 2.29E-02 11.30% 4354 10513190 D630039A03Rik 0.3 1.2 7.7 2.29E-02 11.31% 4355 10524422 Dao -0.2 0.9 4.7 2.29E-02 11.31% 4356 10398240 Eml1 -0.2 0.9 6.7 2.29E-02 11.31% 4357 10541260 Cecr2 -0.3 0.8 7.7 2.29E-02 11.31% 4358 10603785 Fundc1 0.4 1.3 8.6 2.29E-02 11.31% 4359 10464359 0.2 1.1 5.7 2.29E-02 11.31% 4360 10474159 Apip 0.3 1.2 7.5 2.29E-02 11.31% 4361 10544717 -0.3 0.8 5.0 2.29E-02 11.31% 4362 10543471 Pot1a 0.3 1.2 7.4 2.29E-02 11.31% 4363 10457345 Armc4 -0.2 0.9 4.2 2.29E-02 11.31% 4364 10339765 0.5 1.4 8.8 2.30E-02 11.31% 4365 10338719 -0.3 0.8 7.1 2.30E-02 11.31% 4366 10395735 0.1 1.1 2.7 2.30E-02 11.31% 4367 10598198 Mia3 -0.2 0.9 9.7 2.30E-02 11.32% 4368 10428536 Trps1 0.2 1.1 6.1 2.30E-02 11.32% 4369 10524388 Tmem211 -0.3 0.8 5.6 2.30E-02 11.32% 4370 10557397 -0.2 0.9 6.7 2.30E-02 11.32% 4371 10582814 Tomm20 0.2 1.2 9.0 2.30E-02 11.32% 4372 10372796 Hmga2 -0.2 0.9 6.2 2.30E-02 11.32% 4373 10498095 Cog6 0.2 1.2 9.0 2.30E-02 11.32% 4374 10520734 Nrbp1 0.2 1.1 10.5 2.30E-02 11.32% 4375 10429128 Sla 0.3 1.2 6.9 2.30E-02 11.32% 4376 10547396 Wnt5b 0.2 1.1 7.0 2.30E-02 11.32%

Page 107 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4377 10344469 -0.5 0.7 4.2 2.30E-02 11.32% 4378 10532997 -0.2 0.8 5.5 2.30E-02 11.32% 4379 10532169 Mfsd7a -0.2 0.9 6.8 2.31E-02 11.32% 4380 10467826 Hpse2 -0.2 0.9 5.4 2.31E-02 11.32% 4381 10347273 Rpl37a 0.2 1.1 11.0 2.31E-02 11.35% 4382 10428353 Lrp12 0.2 1.1 7.3 2.31E-02 11.35% 4383 10450814 Ppp1r11 0.3 1.2 8.0 2.31E-02 11.35% 4384 10496077 Agxt2l1 -0.9 0.6 9.4 2.31E-02 11.35% 4385 10599673 Slxl1 0.4 1.3 3.7 2.32E-02 11.36% 4386 10541711 Phb2 -0.1 0.9 11.5 2.32E-02 11.36% 4387 10503085 Tgs1 0.2 1.2 7.7 2.32E-02 11.37% 4388 10401933 -0.2 0.9 5.9 2.32E-02 11.37% 4389 10504759 -0.2 0.9 5.9 2.32E-02 11.37% 4390 10353991 0.2 1.1 12.4 2.32E-02 11.37% 4391 10517924 Clcnkb -0.2 0.9 6.3 2.32E-02 11.37% 4392 10429234 Col22a1 -0.2 0.8 6.8 2.32E-02 11.37% 4393 10464560 Aldh3b1 0.2 1.2 6.6 2.32E-02 11.37% 4394 10518167 Trappc2 0.3 1.2 9.1 2.32E-02 11.37% 4395 10339044 0.5 1.4 3.2 2.32E-02 11.37% 4396 10598648 Gm14483 -0.2 0.9 5.9 2.32E-02 11.37% 4397 10601298 Cdx4 0.3 1.2 3.8 2.33E-02 11.37% 4398 10338098 -0.4 0.8 6.7 2.33E-02 11.38% 4399 10489985 Atp9a -0.1 0.9 9.0 2.33E-02 11.38% 4400 10471880 Mir181b-2 -0.3 0.8 5.7 2.33E-02 11.38% 4401 10563659 Spty2d1 0.3 1.2 7.8 2.33E-02 11.38% 4402 10354111 Aff3 -0.2 0.9 6.1 2.33E-02 11.38% 4403 10530151 Tlr6 0.3 1.2 5.7 2.33E-02 11.39% 4404 10449629 0.2 1.2 4.3 2.33E-02 11.39% 4405 10338975 -0.3 0.8 4.2 2.33E-02 11.39% 4406 10586074 -0.3 0.8 6.4 2.33E-02 11.39% 4407 10448842 Telo2 0.2 1.1 6.6 2.33E-02 11.39% 4408 10505374 Col27a1 -0.2 0.9 7.4 2.33E-02 11.39% 4409 10361834 Txlnb -0.3 0.8 5.7 2.34E-02 11.39% 4410 10350592 3110040M04Rik -0.2 0.9 6.3 2.34E-02 11.39% 4411 10363563 Slc25a16 -0.1 0.9 11.0 2.34E-02 11.39% 4412 10405174 Nxnl2 -0.2 0.9 6.0 2.34E-02 11.39% 4413 10561911 Lrfn3 0.2 1.2 6.1 2.34E-02 11.39% 4414 10339602 0.4 1.3 7.0 2.34E-02 11.39% 4415 10401063 Zbtb25 0.3 1.2 6.6 2.34E-02 11.39% 4416 10479925 5430407P10Rik -0.2 0.9 7.9 2.34E-02 11.39% 4417 10428412 Nudcd1 0.3 1.3 8.2 2.34E-02 11.39%

Page 108 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4418 10472361 -0.2 0.9 6.6 2.34E-02 11.39% 4419 10421911 Pcdh20 -0.2 0.9 4.7 2.34E-02 11.39% 4420 10453114 Dhx57 0.2 1.1 8.4 2.34E-02 11.39% 4421 10376938 Cdrt4 -0.2 0.9 4.6 2.34E-02 11.39% 4422 10429387 Ptplb -0.2 0.8 12.0 2.34E-02 11.39% 4423 10446423 5430411C19Rik -0.3 0.8 6.0 2.34E-02 11.39% 4424 10536429 Tmem106b -0.3 0.8 10.4 2.34E-02 11.40% 4425 10404988 C030044B11Rik -0.2 0.9 7.0 2.35E-02 11.40% 4426 10344374 0.7 1.6 3.3 2.35E-02 11.40% 4427 10342507 0.5 1.4 4.1 2.35E-02 11.40% 4428 10399680 Cys1 -0.2 0.9 6.7 2.35E-02 11.40% 4429 10342992 0.3 1.2 2.6 2.35E-02 11.40% 4430 10527713 Rxfp2 -0.2 0.9 4.5 2.35E-02 11.40% 4431 10339386 0.4 1.3 5.8 2.35E-02 11.41% 4432 10420019 -0.2 0.9 5.1 2.35E-02 11.41% 4433 10351502 Dusp12 -0.2 0.8 6.1 2.35E-02 11.41% 4434 10506880 Kti12 0.3 1.2 10.4 2.35E-02 11.42% 4435 10539692 Tgfa -0.2 0.9 7.8 2.35E-02 11.42% 4436 10500720 Slc22a15 -0.3 0.8 7.1 2.36E-02 11.42% 4437 10472923 Ak4 -0.5 0.7 11.5 2.36E-02 11.42% 4438 10486061 Rasgrp1 0.3 1.2 7.0 2.36E-02 11.42% 4439 10547471 B4galnt3 -0.2 0.9 6.7 2.36E-02 11.43% 4440 10604148 Rhox8 -0.2 0.9 5.2 2.36E-02 11.44% 4441 10494804 Casq2 -0.2 0.8 5.0 2.36E-02 11.45% 4442 10340060 0.3 1.3 7.1 2.36E-02 11.45% 4443 10457961 Sft2d3 -0.2 0.9 7.5 2.37E-02 11.45% 4444 10598218 Gm2799 0.4 1.3 3.5 2.37E-02 11.46% 4445 10376603 Drg2 0.2 1.1 9.0 2.37E-02 11.46% 4446 10363868 Fam13c -0.2 0.9 5.8 2.37E-02 11.46% 4447 10517980 Tmem82 0.1 1.1 8.5 2.37E-02 11.46% 4448 10407742 Actn2 -0.6 0.7 6.3 2.37E-02 11.46% 4449 10574676 Nol3 0.2 1.1 6.9 2.37E-02 11.46% 4450 10510629 Nol9 0.3 1.2 8.6 2.37E-02 11.47% 4451 10387257 Alox8 -0.2 0.9 5.9 2.37E-02 11.47% 4452 10372441 -0.2 0.9 5.5 2.37E-02 11.47% 4453 10375214 Mir218-2 -0.3 0.8 5.6 2.37E-02 11.47% 4454 10495830 Sec24d 0.4 1.3 9.9 2.37E-02 11.47% 4455 10341966 -0.5 0.7 6.4 2.38E-02 11.47% 4456 10404400 -0.2 0.9 5.7 2.38E-02 11.47% 4457 10498827 Fnip2 -0.4 0.8 8.7 2.38E-02 11.47% 4458 10606393 Brwd3 0.2 1.2 7.6 2.38E-02 11.47%

Page 109 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4459 10540227 Kbtbd8 0.4 1.3 5.8 2.38E-02 11.47% 4460 10400334 Rpl31 0.2 1.1 9.7 2.38E-02 11.48% 4461 10497250 -0.3 0.8 6.8 2.38E-02 11.48% 4462 10587558 Dopey1 0.2 1.1 7.8 2.38E-02 11.48% 4463 10548905 Eps8 -0.2 0.9 6.9 2.38E-02 11.48% 4464 10354432 Myo1b -0.3 0.8 10.4 2.38E-02 11.48% 4465 10596967 Atrip 0.2 1.1 7.2 2.38E-02 11.48% 4466 10455959 -0.2 0.9 5.1 2.38E-02 11.48% 4467 10473058 Osbpl6 -0.3 0.8 5.6 2.38E-02 11.48% 4468 10533050 Hspb8 0.3 1.2 10.7 2.39E-02 11.50% 4469 10457836 Nol4 -0.3 0.8 7.3 2.39E-02 11.50% 4470 10386965 Arhgap44 -0.2 0.9 5.8 2.39E-02 11.51% 4471 10579525 Plvap 0.2 1.1 8.1 2.39E-02 11.51% 4472 10351691 Slamf6 0.3 1.2 5.6 2.39E-02 11.51% 4473 10538751 Atoh1 -0.3 0.8 5.7 2.39E-02 11.51% 4474 10575630 Cntnap4 -0.3 0.8 6.1 2.39E-02 11.51% 4475 10608721 Sts -0.2 0.8 8.9 2.39E-02 11.51% 4476 10340460 0.2 1.2 9.1 2.40E-02 11.51% 4477 10470050 Abca2 0.2 1.1 8.8 2.40E-02 11.51% 4478 10415604 Gjb2 0.6 1.5 8.9 2.40E-02 11.52% 4479 10443344 -0.2 0.9 7.3 2.40E-02 11.53% 4480 10588849 Amigo3 0.2 1.2 6.0 2.40E-02 11.53% 4481 10459225 Mir145 -0.3 0.8 5.1 2.40E-02 11.53% 4482 10341211 0.8 1.7 6.2 2.40E-02 11.53% 4483 10342790 -0.8 0.6 4.8 2.40E-02 11.54% 4484 10391429 0.2 1.2 2.5 2.40E-02 11.54% 4485 10350199 Cacna1s -0.2 0.8 5.9 2.41E-02 11.54% 4486 10543872 3110062M04Rik 0.2 1.2 6.5 2.41E-02 11.54% 4487 10400668 Nemf 0.3 1.2 8.3 2.41E-02 11.54% 4488 10603228 0.3 1.3 6.0 2.41E-02 11.54% 4489 10519060 Tnfrsf14 -0.2 0.9 8.1 2.41E-02 11.54% 4490 10497904 Nudt6 -0.2 0.9 7.9 2.41E-02 11.54% 4491 10570141 -0.2 0.9 4.5 2.41E-02 11.54% 4492 10419005 Rgr -0.2 0.9 5.8 2.41E-02 11.56% 4493 10396231 Tomm20l -0.2 0.9 6.1 2.41E-02 11.56% 4494 10364810 Onecut3 -0.2 0.9 7.0 2.42E-02 11.57% 4495 10439346 Eaf2 -0.1 0.9 5.7 2.42E-02 11.59% 4496 10375901 -0.2 0.9 5.5 2.42E-02 11.59% 4497 10495083 Kcnd3 -0.2 0.9 5.5 2.42E-02 11.59% 4498 10343809 -0.5 0.7 6.8 2.43E-02 11.60% 4499 10495549 Dbt -0.2 0.8 11.1 2.43E-02 11.61%

Page 110 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4500 10543600 Kcp -0.2 0.9 6.5 2.43E-02 11.62% 4501 10571214 Rnf122 -0.2 0.9 6.6 2.43E-02 11.62% 4502 10341128 -0.3 0.8 8.8 2.43E-02 11.62% 4503 10372965 Usp15 0.2 1.1 9.4 2.43E-02 11.62% 4504 10402490 4831426I19Rik 0.2 1.1 6.8 2.43E-02 11.63% 4505 10474921 Zfyve19 0.2 1.2 7.1 2.44E-02 11.63% 4506 10454063 Rsl24d1 0.2 1.2 8.5 2.44E-02 11.63% 4507 10340055 0.3 1.2 7.9 2.44E-02 11.65% 4508 10542270 -0.2 0.9 6.7 2.44E-02 11.65% 4509 10524909 Nos1 -0.2 0.9 6.4 2.44E-02 11.65% 4510 10348547 Ube2f 0.2 1.2 8.2 2.44E-02 11.65% 4511 10390426 Arhgap23 -0.3 0.8 5.7 2.44E-02 11.65% 4512 10541482 Nhp2l1 0.3 1.2 10.4 2.44E-02 11.65% 4513 10516776 -0.2 0.9 6.5 2.45E-02 11.65% 4514 10340332 -0.6 0.7 4.7 2.45E-02 11.68% 4515 10348493 Lrrfip1 -0.2 0.9 6.8 2.45E-02 11.68% 4516 10470388 5930434B04Rik 0.2 1.2 7.7 2.45E-02 11.68% 4517 10532857 Gltp 0.2 1.2 8.1 2.45E-02 11.68% 4518 10536711 Lmod2 -0.3 0.8 5.6 2.45E-02 11.68% 4519 10427898 Fbxl7 -0.3 0.8 6.9 2.45E-02 11.68% 4520 10580897 Prss54 -0.2 0.9 5.3 2.46E-02 11.68% 4521 10338312 -0.5 0.7 5.9 2.46E-02 11.68% 4522 10344424 0.6 1.5 4.0 2.46E-02 11.69% 4523 10482486 Mmadhc 0.2 1.1 9.3 2.46E-02 11.69% 4524 10577604 Agpat6 -0.2 0.8 9.0 2.46E-02 11.69% 4525 10339646 -0.4 0.8 6.4 2.46E-02 11.70% 4526 10344723 Rrs1 0.4 1.3 6.6 2.46E-02 11.70% 4527 10581378 Psmb10 0.4 1.3 8.9 2.46E-02 11.70% 4528 10517243 Pdik1l 0.2 1.2 7.5 2.46E-02 11.70% 4529 10530259 9130230L23Rik 0.2 1.1 5.2 2.46E-02 11.70% 4530 10401519 Npc2 0.2 1.1 8.8 2.47E-02 11.70% 4531 10570855 Plat -0.3 0.8 5.3 2.47E-02 11.70% 4532 10363528 Aifm2 -0.2 0.8 7.4 2.47E-02 11.70% 4533 10584435 Vwa5a 0.2 1.2 8.9 2.47E-02 11.70% 4534 10355893 Epha4 -0.2 0.9 5.8 2.47E-02 11.70% 4535 10342728 0.4 1.3 8.8 2.47E-02 11.70% 4536 10546659 -0.2 0.9 8.4 2.47E-02 11.71% 4537 10346250 Mstn -0.2 0.9 4.4 2.47E-02 11.71% 4538 10437737 Rsl1d1 0.3 1.2 9.5 2.47E-02 11.71% 4539 10392098 Ftsj3 0.3 1.2 8.2 2.47E-02 11.71% 4540 10476497 Ankrd5 -0.1 0.9 4.9 2.48E-02 11.73%

Page 111 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4541 10511149 Mrpl20 0.2 1.2 9.2 2.48E-02 11.73% 4542 10340265 -0.3 0.8 7.8 2.48E-02 11.73% 4543 10472820 Itga6 0.3 1.3 6.6 2.48E-02 11.73% 4544 10381930 -0.3 0.8 7.9 2.48E-02 11.73% 4545 10351603 Arhgap30 0.2 1.1 6.6 2.48E-02 11.73% 4546 10434384 Ap2m1 0.1 1.1 10.4 2.48E-02 11.73% 4547 10576173 Gm16378 0.8 1.7 5.1 2.48E-02 11.73% 4548 10557925 -0.4 0.8 7.0 2.48E-02 11.73% 4549 10360957 Kctd3 0.2 1.1 7.6 2.48E-02 11.73% 4550 10503828 Lyrm2 0.2 1.2 8.0 2.48E-02 11.73% 4551 10393879 -0.3 0.8 8.7 2.48E-02 11.74% 4552 10501485 Prmt6 0.2 1.2 6.4 2.49E-02 11.75% 4553 10515590 Kdm4a 0.1 1.1 8.2 2.49E-02 11.75% 4554 10340405 0.7 1.6 6.3 2.49E-02 11.76% 4555 10357529 C4bp-ps1 -0.3 0.8 4.1 2.49E-02 11.76% 4556 10599369 Xiap -0.2 0.9 9.3 2.49E-02 11.77% 4557 10390939 Krtap4-13 -0.2 0.9 7.2 2.49E-02 11.77% 4558 10531919 Hsd17b11 -0.2 0.9 11.7 2.49E-02 11.77% 4559 10437270 Cluap1 -0.2 0.9 6.6 2.49E-02 11.77% 4560 10453632 Rpl7a 0.2 1.2 9.1 2.49E-02 11.77% 4561 10433575 -0.3 0.8 6.4 2.49E-02 11.77% 4562 10599498 Utp14a 0.2 1.2 7.0 2.50E-02 11.77% 4563 10343034 -0.3 0.8 7.6 2.50E-02 11.77% 4564 10348558 Scly 0.2 1.1 9.8 2.50E-02 11.78% 4565 10550222 Zfp541 -0.2 0.9 6.1 2.50E-02 11.78% 4566 10451225 Polh 0.3 1.2 6.8 2.50E-02 11.80% 4567 10574220 Cx3cl1 -0.2 0.9 6.3 2.51E-02 11.81% 4568 10512714 Shb 0.2 1.2 8.5 2.51E-02 11.81% 4569 10532582 Myo18b -0.2 0.8 6.3 2.51E-02 11.81% 4570 10463670 Sfxn2 -0.3 0.8 8.7 2.51E-02 11.81% 4571 10340178 0.4 1.3 5.3 2.51E-02 11.81% 4572 10560728 Vmn1r158 0.3 1.2 4.0 2.51E-02 11.81% 4573 10495876 -0.2 0.9 3.3 2.51E-02 11.81% 4574 10545932 Snrnp27 0.2 1.2 8.8 2.51E-02 11.82% 4575 10435789 -0.3 0.8 10.8 2.51E-02 11.82% 4576 10581111 Nae1 0.2 1.2 9.1 2.51E-02 11.82% 4577 10358459 BC003331 0.2 1.1 8.4 2.51E-02 11.82% 4578 10381514 Cd300lg -0.2 0.8 8.7 2.52E-02 11.82% 4579 10343383 0.3 1.3 10.2 2.52E-02 11.82% 4580 10576189 0.4 1.3 4.6 2.52E-02 11.83% 4581 10400635 Rps29 0.2 1.2 9.6 2.52E-02 11.83%

Page 112 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4582 10377859 Pld2 0.2 1.1 7.3 2.52E-02 11.83% 4583 10435791 Mir568 -0.4 0.8 8.1 2.52E-02 11.83% 4584 10414202 Sftpa1 -0.2 0.9 6.7 2.52E-02 11.83% 4585 10547251 Bms1 0.2 1.2 7.8 2.52E-02 11.83% 4586 10490813 -0.1 0.9 6.2 2.52E-02 11.83% 4587 10451123 Slc29a1 -0.2 0.8 11.0 2.52E-02 11.84% 4588 10442236 3110052M02Rik 0.3 1.2 8.2 2.52E-02 11.84% 4589 10555753 Olfr574 -0.3 0.8 4.9 2.53E-02 11.84% 4590 10563820 Svip -0.2 0.9 8.6 2.53E-02 11.85% 4591 10340599 0.4 1.4 4.9 2.53E-02 11.85% 4592 10343399 0.2 1.1 10.3 2.53E-02 11.85% 4593 10479973 -0.2 0.8 4.7 2.53E-02 11.85% 4594 10549388 Pthlh -0.2 0.9 6.4 2.53E-02 11.85% 4595 10505884 Ifna6 -0.3 0.8 4.9 2.53E-02 11.85% 4596 10429083 Kcnq3 -0.2 0.8 6.3 2.53E-02 11.85% 4597 10535080 Cox19 0.2 1.1 7.4 2.53E-02 11.85% 4598 10489107 Samhd1 0.2 1.2 9.4 2.53E-02 11.85% 4599 10455542 Ap3s1 0.2 1.2 9.7 2.53E-02 11.85% 4600 10485674 2700007P21Rik 0.3 1.2 7.7 2.53E-02 11.85% 4601 10339118 0.6 1.5 5.6 2.53E-02 11.85% 4602 10504002 Spink4 -0.3 0.8 6.3 2.54E-02 11.86% 4603 10402440 Gsc -0.3 0.8 6.9 2.54E-02 11.86% 4604 10379557 Gm11426 -0.2 0.8 5.8 2.54E-02 11.86% 4605 10560795 Vmn1r158 0.2 1.2 3.9 2.54E-02 11.86% 4606 10449697 -0.2 0.9 5.2 2.54E-02 11.86% 4607 10364155 2610028H24Rik -0.2 0.9 6.5 2.54E-02 11.86% 4608 10481772 Garnl3 -0.3 0.8 6.1 2.54E-02 11.86% 4609 10605552 -0.2 0.9 7.7 2.54E-02 11.86% 4610 10542615 Slco1b2 -0.1 0.9 11.7 2.54E-02 11.86% 4611 10533858 Eif2b1 0.2 1.1 8.3 2.54E-02 11.86% 4612 10424250 Snrpd2 0.2 1.1 8.2 2.54E-02 11.86% 4613 10362472 Rsph4a 0.9 1.9 7.8 2.54E-02 11.86% 4614 10526181 Gatsl2 0.2 1.1 6.8 2.55E-02 11.87% 4615 10491721 Spry1 0.2 1.1 7.5 2.55E-02 11.87% 4616 10511703 Ripk2 0.2 1.2 8.7 2.55E-02 11.87% 4617 10500896 0.2 1.2 11.3 2.55E-02 11.87% 4618 10365005 Dapk3 0.2 1.1 8.3 2.55E-02 11.87% 4619 10532937 Unc119b 0.2 1.1 8.3 2.55E-02 11.87% 4620 10585555 Pstpip1 -0.2 0.9 6.1 2.55E-02 11.87% 4621 10453602 0.2 1.2 6.0 2.55E-02 11.87% 4622 10600471 -0.3 0.8 7.1 2.55E-02 11.87%

Page 113 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4623 10548497 Klra6 0.3 1.2 3.9 2.55E-02 11.87% 4624 10450579 Ddr1 -0.2 0.9 6.1 2.55E-02 11.87% 4625 10547858 Gnb3 -0.2 0.9 5.5 2.55E-02 11.87% 4626 10339957 -0.3 0.8 8.6 2.55E-02 11.87% 4627 10342385 -0.4 0.8 4.9 2.55E-02 11.87% 4628 10454655 Apc -0.2 0.9 8.8 2.55E-02 11.87% 4629 10342465 -0.4 0.8 6.7 2.56E-02 11.88% 4630 10545720 Stambp 0.2 1.1 8.5 2.56E-02 11.88% 4631 10476889 Nxt1 0.2 1.1 7.5 2.56E-02 11.89% 4632 10451167 Tmem63b -0.3 0.8 10.0 2.56E-02 11.90% 4633 10494085 Selenbp2 -0.2 0.9 9.1 2.56E-02 11.90% 4634 10458183 Gfra3 -0.2 0.9 5.9 2.56E-02 11.90% 4635 10398795 Aspg -0.2 0.8 9.2 2.57E-02 11.90% 4636 10556509 Spon1 -0.2 0.9 5.8 2.57E-02 11.90% 4637 10597461 Cmtm7 0.2 1.2 7.0 2.57E-02 11.90% 4638 10529425 Nop14 0.2 1.2 7.7 2.57E-02 11.90% 4639 10568131 2900092E17Rik 0.2 1.1 8.7 2.57E-02 11.90% 4640 10364385 Ilvbl -0.1 0.9 7.6 2.57E-02 11.90% 4641 10445232 3110082D06Rik -0.2 0.9 6.1 2.57E-02 11.90% 4642 10350392 Aspm 0.5 1.4 5.4 2.57E-02 11.90% 4643 10481128 Med22 0.2 1.1 7.5 2.57E-02 11.90% 4644 10398354 0.5 1.4 5.4 2.57E-02 11.91% 4645 10572747 Tpm4 0.2 1.2 9.5 2.57E-02 11.91% 4646 10568363 Armcx3 0.4 1.4 8.1 2.57E-02 11.92% 4647 10501397 Tmem167b 0.2 1.1 9.9 2.58E-02 11.93% 4648 10478283 Mphosph6 0.6 1.6 4.0 2.58E-02 11.93% 4649 10592399 Olfr945 0.2 1.1 2.7 2.58E-02 11.93% 4650 10608695 LOC100044193 0.2 1.2 7.7 2.58E-02 11.93% 4651 10393058 H3f3b 0.2 1.2 11.3 2.58E-02 11.94% 4652 10599837 -0.2 0.9 6.8 2.58E-02 11.94% 4653 10509002 Rhd 0.2 1.2 5.0 2.58E-02 11.94% 4654 10439084 Gm10818 -0.2 0.9 6.2 2.58E-02 11.94% 4655 10342643 0.5 1.4 4.2 2.58E-02 11.94% 4656 10368935 Qrsl1 0.2 1.2 6.9 2.59E-02 11.94% 4657 10435745 Gm16498 -0.2 0.9 4.2 2.59E-02 11.94% 4658 10403756 1600012F09Rik 0.2 1.1 8.8 2.59E-02 11.94% 4659 10407916 1600012F09Rik 0.2 1.1 8.8 2.59E-02 11.94% 4660 10418275 Ccdc66 0.4 1.3 7.3 2.59E-02 11.94% 4661 10514405 Plaa 0.2 1.1 9.7 2.59E-02 11.94% 4662 10366346 Phlda1 0.6 1.5 9.7 2.59E-02 11.95% 4663 10507961 Mtf1 0.2 1.2 7.9 2.59E-02 11.95%

Page 114 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4664 10547767 Mir200c -0.3 0.8 5.3 2.59E-02 11.96% 4665 10340295 -0.4 0.8 9.8 2.59E-02 11.96% 4666 10538638 -0.3 0.8 7.8 2.60E-02 11.96% 4667 10574096 Ap3s1 0.2 1.2 10.2 2.60E-02 11.97% 4668 10389775 Pctp 0.7 1.6 8.6 2.60E-02 11.97% 4669 10530731 Srd5a3 -0.2 0.9 7.6 2.60E-02 11.97% 4670 10360018 Fcrla -0.2 0.9 5.3 2.60E-02 11.97% 4671 10451818 Sult1c2 0.4 1.3 8.6 2.60E-02 11.98% 4672 10530641 Usp46 0.2 1.2 8.1 2.60E-02 11.99% 4673 10403396 Adarb2 -0.2 0.9 4.6 2.61E-02 12.00% 4674 10342642 0.4 1.4 5.5 2.61E-02 12.00% 4675 10479268 Wtap 0.2 1.2 11.2 2.61E-02 12.00% 4676 10443120 -0.2 0.8 8.3 2.61E-02 12.00% 4677 10605104 Pdzd4 -0.2 0.9 5.9 2.61E-02 12.00% 4678 10556458 Rassf10 -0.2 0.8 5.7 2.61E-02 12.00% 4679 10525885 Ubc -0.3 0.8 8.3 2.61E-02 12.01% 4680 10580850 -0.3 0.8 5.6 2.61E-02 12.01% 4681 10454564 Ercc3 0.1 1.1 9.1 2.61E-02 12.01% 4682 10532588 Myo18b -0.2 0.8 9.2 2.61E-02 12.01% 4683 10563615 Hps5 0.2 1.1 7.3 2.62E-02 12.01% 4684 10504199 -0.2 0.9 6.6 2.62E-02 12.01% 4685 10566184 Olfr569 0.2 1.2 5.0 2.62E-02 12.02% 4686 10390841 Krt12 -0.3 0.8 6.4 2.62E-02 12.02% 4687 10343761 0.4 1.3 5.7 2.62E-02 12.03% 4688 10598251 Dgkk -0.2 0.9 5.2 2.62E-02 12.03% 4689 10344010 0.2 1.2 11.1 2.62E-02 12.04% 4690 10467907 Erlin1 0.2 1.1 9.6 2.63E-02 12.04% 4691 10339664 -0.3 0.8 2.7 2.63E-02 12.04% 4692 10342355 -0.6 0.7 6.1 2.63E-02 12.04% 4693 10415332 Rec8 -0.1 0.9 5.6 2.63E-02 12.06% 4694 10598091 0.5 1.4 9.0 2.63E-02 12.06% 4695 10469110 Usp6nl 0.3 1.2 8.7 2.63E-02 12.06% 4696 10455912 Isoc1 -0.1 0.9 11.5 2.63E-02 12.07% 4697 10453055 Gm10494 -0.3 0.8 4.3 2.64E-02 12.07% 4698 10534405 Wbscr22 0.2 1.2 9.6 2.64E-02 12.07% 4699 10366186 Ccdc59 0.3 1.2 7.2 2.64E-02 12.07% 4700 10590631 Ccr2 0.3 1.2 5.0 2.64E-02 12.07% 4701 10340828 0.6 1.6 6.2 2.64E-02 12.08% 4702 10539002 Rnf103 -0.2 0.9 9.3 2.64E-02 12.08% 4703 10549962 0.2 1.1 4.8 2.64E-02 12.09% 4704 10577792 Plekha2 0.2 1.2 6.7 2.64E-02 12.09%

Page 115 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4705 10603232 Gm2799 0.4 1.3 3.6 2.65E-02 12.10% 4706 10603237 Gm2799 0.4 1.3 3.6 2.65E-02 12.10% 4707 10427222 Amhr2 -0.2 0.9 5.8 2.65E-02 12.10% 4708 10548879 Mgp -0.4 0.8 6.9 2.65E-02 12.10% 4709 10343415 -0.4 0.8 6.1 2.65E-02 12.11% 4710 10394245 Dnajc27 -0.2 0.9 5.2 2.65E-02 12.11% 4711 10395971 0.3 1.2 3.8 2.65E-02 12.11% 4712 10598183 Gm2799 0.4 1.3 3.5 2.65E-02 12.11% 4713 10454953 Tmco6 -0.2 0.9 7.2 2.65E-02 12.11% 4714 10581061 Cmtm4 -0.2 0.9 8.2 2.66E-02 12.11% 4715 10566822 Scube2 -0.2 0.9 6.3 2.66E-02 12.11% 4716 10552469 Klk13 -0.2 0.9 5.9 2.66E-02 12.12% 4717 10380248 Gm15698 -0.2 0.9 5.3 2.66E-02 12.12% 4718 10369748 0.2 1.1 7.9 2.66E-02 12.12% 4719 10350297 Kif14 0.2 1.2 5.2 2.66E-02 12.13% 4720 10424211 0.3 1.3 4.5 2.66E-02 12.13% 4721 10490126 Rps29 0.2 1.2 9.4 2.66E-02 12.13% 4722 10463277 Nkx2-3 -0.3 0.8 5.8 2.66E-02 12.13% 4723 10603492 Porcn 0.2 1.1 7.4 2.67E-02 12.13% 4724 10495621 Mir137 -0.2 0.9 3.0 2.67E-02 12.13% 4725 10442125 Vmn2r99 0.4 1.3 3.3 2.67E-02 12.13% 4726 10412376 Emb -0.3 0.8 6.1 2.67E-02 12.13% 4727 10362829 Ostm1 0.2 1.1 8.8 2.67E-02 12.13% 4728 10460177 Mtl5 -0.2 0.9 5.9 2.67E-02 12.13% 4729 10577429 Gm7849 -0.4 0.8 6.7 2.67E-02 12.13% 4730 10341210 0.4 1.3 7.5 2.67E-02 12.13% 4731 10342695 0.3 1.2 2.5 2.67E-02 12.13% 4732 10563802 0.2 1.2 4.4 2.67E-02 12.13% 4733 10563804 0.2 1.2 4.4 2.67E-02 12.13% 4734 10563806 0.2 1.2 4.4 2.67E-02 12.13% 4735 10563808 0.2 1.2 4.4 2.67E-02 12.13% 4736 10563810 0.2 1.2 4.4 2.67E-02 12.13% 4737 10563812 0.2 1.2 4.4 2.67E-02 12.13% 4738 10437160 Ets2 0.3 1.2 8.7 2.67E-02 12.13% 4739 10490225 Slmo2 0.2 1.2 9.4 2.67E-02 12.13% 4740 10524018 Rpl34 0.1 1.1 11.2 2.67E-02 12.13% 4741 10340233 -0.4 0.8 6.4 2.67E-02 12.13% 4742 10423570 0.1 1.1 5.1 2.67E-02 12.13% 4743 10503952 Ifnk 0.3 1.2 4.4 2.68E-02 12.13% 4744 10391685 Fam171a2 -0.2 0.9 6.4 2.68E-02 12.13% 4745 10532819 Kctd10 0.3 1.2 7.0 2.68E-02 12.13%

Page 116 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4746 10578279 -0.3 0.8 6.3 2.68E-02 12.13% 4747 10383198 0.2 1.2 8.6 2.68E-02 12.13% 4748 10478469 Svs5 -0.3 0.8 4.4 2.68E-02 12.13% 4749 10354168 Tbc1d8 -0.3 0.8 8.3 2.68E-02 12.13% 4750 10471967 Mbd5 -0.2 0.8 6.4 2.68E-02 12.13% 4751 10497197 5330432E05Rik 0.2 1.2 4.3 2.68E-02 12.13% 4752 10455974 Dctn4 0.2 1.1 8.8 2.68E-02 12.13% 4753 10567879 Atp2a1 -1.0 0.5 6.6 2.68E-02 12.13% 4754 10342653 0.7 1.6 5.8 2.68E-02 12.14% 4755 10342649 0.5 1.5 3.0 2.69E-02 12.16% 4756 10589511 Scap -0.2 0.9 9.8 2.69E-02 12.16% 4757 10338601 0.3 1.3 8.1 2.69E-02 12.16% 4758 10368162 Pex7 -0.2 0.9 9.5 2.69E-02 12.16% 4759 10341970 -0.7 0.6 5.8 2.69E-02 12.16% 4760 10534420 Vps37d -0.2 0.9 7.6 2.69E-02 12.17% 4761 10389732 Gm15698 0.2 1.2 5.8 2.69E-02 12.17% 4762 10596880 Bsn -0.2 0.9 5.9 2.69E-02 12.17% 4763 10417371 Gm3696 0.4 1.3 4.1 2.70E-02 12.17% 4764 10477370 Tomm20 0.2 1.2 9.2 2.70E-02 12.17% 4765 10593260 Ankk1 -0.2 0.9 5.5 2.70E-02 12.17% 4766 10439660 Gm609 -0.3 0.8 4.6 2.70E-02 12.17% 4767 10569341 H19 -0.4 0.7 6.0 2.70E-02 12.17% 4768 10606186 Slc16a2 -0.2 0.9 10.5 2.70E-02 12.17% 4769 10480087 0.5 1.4 8.2 2.70E-02 12.18% 4770 10339749 0.2 1.1 9.9 2.70E-02 12.18% 4771 10413434 D14Abb1e -0.2 0.8 8.6 2.70E-02 12.18% 4772 10412296 -0.2 0.9 4.9 2.70E-02 12.18% 4773 10546113 Sec61a1 0.2 1.2 12.2 2.70E-02 12.18% 4774 10341199 -0.5 0.7 5.7 2.70E-02 12.19% 4775 10444016 Pram1 0.3 1.3 6.2 2.71E-02 12.19% 4776 10515213 Dmbx1 -0.2 0.9 6.0 2.71E-02 12.19% 4777 10526274 Dnajc30 0.2 1.1 8.8 2.71E-02 12.19% 4778 10341833 -0.3 0.8 7.5 2.71E-02 12.19% 4779 10516706 Khdrbs1 0.1 1.1 8.4 2.71E-02 12.19% 4780 10384032 Pold2 0.3 1.2 8.7 2.71E-02 12.19% 4781 10343829 -0.4 0.8 8.4 2.71E-02 12.20% 4782 10578253 Sgcz -0.1 0.9 4.9 2.71E-02 12.20% 4783 10425653 4930407I10Rik -0.2 0.9 5.7 2.71E-02 12.20% 4784 10361381 Syne1 -0.2 0.9 6.9 2.71E-02 12.20% 4785 10473847 Acp2 0.1 1.1 9.9 2.71E-02 12.20% 4786 10601150 0.2 1.2 6.0 2.71E-02 12.20%

Page 117 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4787 10463068 Ptp4a1 -0.3 0.8 11.8 2.72E-02 12.20% 4788 10457872 Slc39a6 0.2 1.1 6.1 2.72E-02 12.20% 4789 10573713 Heatr3 0.2 1.2 7.6 2.72E-02 12.20% 4790 10598422 Gripap1 0.2 1.2 7.8 2.72E-02 12.20% 4791 10342591 0.6 1.5 5.2 2.72E-02 12.20% 4792 10496971 Asb17 -0.2 0.9 4.1 2.72E-02 12.20% 4793 10516605 Hdac1 0.2 1.1 8.7 2.72E-02 12.20% 4794 10407390 Ptbp1 0.2 1.2 8.9 2.72E-02 12.20% 4795 10490378 Hrh3 -0.2 0.9 6.0 2.72E-02 12.20% 4796 10513544 Zfp37 -0.2 0.9 5.9 2.72E-02 12.21% 4797 10344395 0.3 1.3 4.0 2.72E-02 12.21% 4798 10471474 Ak1 -0.4 0.8 6.0 2.72E-02 12.22% 4799 10420532 Atp8a2 -0.2 0.9 6.2 2.73E-02 12.23% 4800 10586933 Nedd4 -0.2 0.9 11.1 2.73E-02 12.23% 4801 10350760 -0.3 0.8 5.4 2.73E-02 12.23% 4802 10515132 -0.2 0.8 7.7 2.73E-02 12.23% 4803 10602677 Gpr143 -0.2 0.9 4.9 2.73E-02 12.24% 4804 10339296 0.3 1.2 8.4 2.73E-02 12.24% 4805 10557628 Zfp689 -0.2 0.9 6.8 2.73E-02 12.24% 4806 10461690 Osbp 0.3 1.2 9.8 2.73E-02 12.24% 4807 10419261 Bmp4 -0.3 0.8 7.6 2.73E-02 12.24% 4808 10414973 -0.3 0.8 6.3 2.74E-02 12.24% 4809 10554926 Ccdc90b 0.3 1.3 7.9 2.74E-02 12.24% 4810 10587690 Bcl2a1b 0.2 1.1 6.2 2.74E-02 12.25% 4811 10415742 Mipep 0.2 1.2 9.3 2.74E-02 12.26% 4812 10504703 Ncbp1 0.3 1.2 9.7 2.74E-02 12.26% 4813 10482181 Strbp -0.2 0.9 8.4 2.74E-02 12.26% 4814 10591612 Dock6 -0.2 0.9 7.8 2.74E-02 12.26% 4815 10434189 -0.2 0.9 4.4 2.75E-02 12.27% 4816 10604749 -0.3 0.8 3.6 2.75E-02 12.27% 4817 10421624 Cog3 0.2 1.2 8.0 2.75E-02 12.27% 4818 10458430 Diap1 0.3 1.2 8.5 2.75E-02 12.27% 4819 10344237 -0.5 0.7 4.0 2.75E-02 12.27% 4820 10547674 Vmn2r20 0.2 1.2 5.1 2.75E-02 12.27% 4821 10547682 Vmn2r20 0.2 1.2 5.1 2.75E-02 12.27% 4822 10547684 Vmn2r20 0.2 1.2 5.1 2.75E-02 12.27% 4823 10546510 Lrig1 0.2 1.1 8.0 2.75E-02 12.27% 4824 10340947 -0.5 0.7 7.0 2.75E-02 12.27% 4825 10505102 -0.3 0.8 5.1 2.76E-02 12.28% 4826 10594762 Fam81a -0.3 0.8 6.8 2.76E-02 12.28% 4827 10485794 Olfr1305 -0.2 0.8 4.3 2.76E-02 12.28%

Page 118 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4828 10387689 Kctd11 0.1 1.1 5.9 2.76E-02 12.28% 4829 10607421 0.4 1.3 4.2 2.76E-02 12.28% 4830 10505118 -0.2 0.9 7.5 2.76E-02 12.28% 4831 10578300 Mtmr7 -0.2 0.9 6.9 2.76E-02 12.28% 4832 10436412 Olfr195 0.2 1.2 3.7 2.76E-02 12.28% 4833 10439701 Abhd10 0.2 1.1 7.1 2.76E-02 12.28% 4834 10367770 -0.2 0.9 5.5 2.76E-02 12.28% 4835 10504670 E230008N13Rik -0.3 0.8 6.1 2.76E-02 12.28% 4836 10479833 Optn -0.3 0.8 9.6 2.76E-02 12.28% 4837 10452445 -0.2 0.9 5.2 2.76E-02 12.28% 4838 10342998 -0.9 0.5 4.5 2.76E-02 12.28% 4839 10382844 Snord1c 0.4 1.3 3.3 2.77E-02 12.29% 4840 10386093 Snord1c 0.4 1.3 3.3 2.77E-02 12.29% 4841 10600502 2810453I06Rik 0.2 1.2 7.4 2.77E-02 12.29% 4842 10473343 Med19 0.2 1.1 8.3 2.77E-02 12.30% 4843 10341927 0.4 1.3 3.0 2.77E-02 12.31% 4844 10608716 -0.2 0.9 6.2 2.77E-02 12.31% 4845 10344558 -0.7 0.6 5.8 2.77E-02 12.31% 4846 10581363 Cenpt 0.3 1.2 6.7 2.78E-02 12.31% 4847 10475782 Dusp2 -0.1 0.9 6.0 2.78E-02 12.31% 4848 10406541 Rps23 0.1 1.1 9.5 2.78E-02 12.31% 4849 10384829 Rps27a 0.1 1.1 8.5 2.78E-02 12.31% 4850 10362422 Trdn -1.0 0.5 3.8 2.78E-02 12.31% 4851 10545513 -0.2 0.9 5.0 2.78E-02 12.31% 4852 10405870 Vmn2r122 0.2 1.2 4.0 2.78E-02 12.31% 4853 10463687 D19Wsu162e -0.2 0.9 11.0 2.78E-02 12.31% 4854 10431393 Mapk12 -0.2 0.9 6.8 2.78E-02 12.31% 4855 10348927 0.4 1.3 2.6 2.78E-02 12.31% 4856 10357562 Il20 -0.2 0.9 5.3 2.78E-02 12.31% 4857 10565385 Olfr308 0.2 1.1 4.1 2.78E-02 12.32% 4858 10546184 Plxna1 0.2 1.1 7.8 2.78E-02 12.32% 4859 10421186 -0.2 0.9 3.8 2.79E-02 12.32% 4860 10606770 Zmat1 -0.3 0.8 6.6 2.79E-02 12.32% 4861 10533122 Sdsl -0.2 0.9 7.1 2.79E-02 12.32% 4862 10410654 -0.3 0.8 8.3 2.79E-02 12.32% 4863 10429500 Slurp1 -0.2 0.9 6.4 2.79E-02 12.32% 4864 10343445 -0.4 0.8 5.7 2.79E-02 12.32% 4865 10430519 Csnk1e -0.2 0.9 7.9 2.79E-02 12.32% 4866 10441987 Chd1 0.2 1.2 8.8 2.79E-02 12.32% 4867 10585233 Alg9 0.2 1.1 9.1 2.79E-02 12.32% 4868 10416023 Scara5 -0.2 0.9 6.2 2.79E-02 12.32%

Page 119 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4869 10525158 Oas1b 0.2 1.2 6.0 2.79E-02 12.34% 4870 10507101 Gm12824 -0.3 0.8 6.7 2.79E-02 12.34% 4871 10442238 3110052M02Rik 0.4 1.3 7.4 2.79E-02 12.34% 4872 10508974 Pafah2 -0.3 0.8 9.1 2.79E-02 12.34% 4873 10560726 -0.3 0.8 6.0 2.80E-02 12.35% 4874 10424260 D15Ertd621e -0.2 0.9 9.6 2.80E-02 12.35% 4875 10585874 Hexa 0.2 1.2 8.9 2.80E-02 12.36% 4876 10339297 -0.3 0.8 8.8 2.80E-02 12.36% 4877 10338217 0.4 1.3 8.5 2.80E-02 12.36% 4878 10490201 Mir298 -0.2 0.8 5.1 2.80E-02 12.36% 4879 10592342 Tbrg1 0.2 1.1 10.7 2.80E-02 12.36% 4880 10489413 Tomm34 0.2 1.1 8.2 2.80E-02 12.36% 4881 10368556 Hey2 -0.2 0.9 5.4 2.80E-02 12.36% 4882 10501183 Eps8l3 0.3 1.2 6.0 2.81E-02 12.37% 4883 10342133 -0.4 0.7 7.7 2.81E-02 12.37% 4884 10496110 Papss1 0.3 1.2 7.1 2.81E-02 12.37% 4885 10370665 Med16 -0.1 0.9 7.9 2.81E-02 12.37% 4886 10426439 Pphln1 0.2 1.1 8.4 2.81E-02 12.37% 4887 10404195 D130043K22Rik -0.2 0.9 6.7 2.81E-02 12.37% 4888 10344041 0.5 1.5 4.6 2.81E-02 12.37% 4889 10538394 Plekha8 0.3 1.2 8.4 2.81E-02 12.37% 4890 10440909 -0.2 0.9 9.0 2.81E-02 12.37% 4891 10500754 Sycp1 0.3 1.2 4.7 2.81E-02 12.37% 4892 10394627 Nbas 0.3 1.2 8.9 2.81E-02 12.37% 4893 10447560 -0.3 0.8 6.4 2.82E-02 12.37% 4894 10390831 Krt10 -0.1 0.9 6.1 2.82E-02 12.37% 4895 10464836 Actn3 -0.4 0.7 5.7 2.82E-02 12.37% 4896 10489522 Wfdc16 -0.2 0.9 5.3 2.82E-02 12.37% 4897 10557862 Itgam 0.3 1.2 6.1 2.82E-02 12.37% 4898 10591164 Zfp558 -0.2 0.9 5.2 2.82E-02 12.40% 4899 10564482 Synm -0.2 0.9 6.5 2.82E-02 12.40% 4900 10552500 Klk8 -0.2 0.9 6.2 2.83E-02 12.41% 4901 10449510 4930539E08Rik -0.2 0.9 6.1 2.83E-02 12.41% 4902 10586170 0.6 1.5 5.1 2.83E-02 12.41% 4903 10338221 -0.2 0.9 12.2 2.83E-02 12.41% 4904 10501811 Slc44a3 -0.2 0.9 8.2 2.83E-02 12.42% 4905 10479902 Dhtkd1 -0.3 0.8 10.8 2.83E-02 12.42% 4906 10430400 Card10 -0.2 0.9 7.2 2.83E-02 12.42% 4907 10358027 Elf3 0.2 1.2 6.1 2.83E-02 12.42% 4908 10572870 Hmgxb4 0.2 1.2 7.1 2.83E-02 12.42% 4909 10338289 0.7 1.6 5.6 2.83E-02 12.42%

Page 120 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4910 10579287 Tmem59l -0.3 0.8 6.3 2.83E-02 12.42% 4911 10584500 Olfr963 -0.3 0.8 4.9 2.84E-02 12.42% 4912 10342152 -0.4 0.7 5.4 2.84E-02 12.42% 4913 10595496 Snap91 -0.3 0.8 6.3 2.84E-02 12.42% 4914 10453715 0.6 1.5 6.9 2.84E-02 12.42% 4915 10438189 Slc7a4 -0.2 0.9 6.2 2.84E-02 12.42% 4916 10430140 Mb -0.6 0.7 6.7 2.84E-02 12.42% 4917 10482237 Nr5a1 -0.2 0.9 6.6 2.84E-02 12.42% 4918 10417732 -0.2 0.9 5.1 2.84E-02 12.42% 4919 10542731 Rassf8 0.2 1.1 8.7 2.84E-02 12.42% 4920 10368947 Aim1 -0.3 0.8 8.0 2.84E-02 12.42% 4921 10436678 Gabpa -0.2 0.9 8.9 2.84E-02 12.42% 4922 10518492 Ptchd2 -0.2 0.9 5.1 2.84E-02 12.42% 4923 10344835 -0.3 0.8 8.3 2.84E-02 12.42% 4924 10586128 0.1 1.1 2.9 2.85E-02 12.43% 4925 10528227 Gnai1 -0.2 0.9 5.7 2.85E-02 12.44% 4926 10598220 Gm2799 0.4 1.3 3.5 2.85E-02 12.44% 4927 10593591 Acat1 -0.4 0.8 11.3 2.85E-02 12.44% 4928 10344048 -0.3 0.8 7.3 2.85E-02 12.44% 4929 10586110 Cln6 0.3 1.2 7.6 2.85E-02 12.44% 4930 10434052 P2rx6 -0.2 0.9 5.7 2.85E-02 12.44% 4931 10414932 -0.2 0.8 7.7 2.85E-02 12.44% 4932 10576951 Tnfsf13b -0.2 0.9 5.5 2.85E-02 12.44% 4933 10342023 -0.5 0.7 6.0 2.86E-02 12.45% 4934 10507520 Hyi -0.2 0.9 9.7 2.86E-02 12.45% 4935 10432122 Asb8 0.2 1.1 8.6 2.86E-02 12.46% 4936 10354368 -0.2 0.8 8.6 2.86E-02 12.46% 4937 10340498 0.3 1.3 5.8 2.86E-02 12.46% 4938 10473252 -0.2 0.9 3.3 2.86E-02 12.46% 4939 10353545 1110058L19Rik 0.3 1.2 7.8 2.86E-02 12.47% 4940 10608698 Zfp429 0.2 1.2 8.3 2.86E-02 12.47% 4941 10502299 Nfkb1 0.1 1.1 8.1 2.87E-02 12.47% 4942 10341661 -0.7 0.6 4.2 2.87E-02 12.47% 4943 10520612 Khk -0.2 0.9 10.5 2.87E-02 12.48% 4944 10355628 Rnf25 0.2 1.1 8.0 2.87E-02 12.48% 4945 10567520 -0.2 0.9 4.9 2.87E-02 12.48% 4946 10483150 Fign 0.3 1.2 7.1 2.87E-02 12.48% 4947 10357332 Actr3 0.2 1.2 9.4 2.87E-02 12.48% 4948 10364468 Bsg 0.1 1.1 11.7 2.87E-02 12.48% 4949 10346298 Coq10b -0.5 0.7 9.4 2.87E-02 12.48% 4950 10414757 -0.2 0.9 5.9 2.87E-02 12.48%

Page 121 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4951 10414863 -0.2 0.9 5.9 2.87E-02 12.48% 4952 10477353 Mapre1 0.3 1.2 8.0 2.87E-02 12.48% 4953 10379564 Lig3 0.2 1.1 8.1 2.87E-02 12.48% 4954 10559399 Oscar -0.2 0.8 6.1 2.88E-02 12.49% 4955 10416531 -0.3 0.8 5.5 2.88E-02 12.50% 4956 10564839 Ap3s2 0.2 1.2 8.2 2.88E-02 12.50% 4957 10420780 Tdh -0.3 0.8 4.5 2.88E-02 12.50% 4958 10566290 -0.3 0.8 5.5 2.88E-02 12.50% 4959 10599948 Gm6812 -0.2 0.9 5.3 2.88E-02 12.50% 4960 10500272 Gm129 -0.9 0.6 7.7 2.88E-02 12.50% 4961 10368224 -0.3 0.8 6.2 2.88E-02 12.51% 4962 10436694 Rplp0 0.2 1.1 12.2 2.89E-02 12.51% 4963 10594638 Aph1c 0.2 1.1 9.2 2.89E-02 12.51% 4964 10505266 -0.5 0.7 7.9 2.89E-02 12.51% 4965 10343112 0.6 1.5 6.9 2.89E-02 12.51% 4966 10498343 0.3 1.2 3.9 2.89E-02 12.51% 4967 10363545 Neurog3 -0.2 0.9 5.5 2.89E-02 12.51% 4968 10399254 Cenpo 0.2 1.1 6.8 2.89E-02 12.51% 4969 10343647 -0.6 0.6 3.0 2.89E-02 12.51% 4970 10363161 Tmem229b 0.3 1.2 6.2 2.89E-02 12.51% 4971 10600044 Prrg3 -0.2 0.9 5.6 2.89E-02 12.51% 4972 10498852 Rxfp1 -0.2 0.9 4.5 2.89E-02 12.51% 4973 10539577 Spr -0.2 0.9 5.5 2.89E-02 12.51% 4974 10580624 Ces1c -0.1 0.9 12.8 2.90E-02 12.51% 4975 10352178 Sccpdh 0.3 1.3 6.5 2.90E-02 12.51% 4976 10338971 0.6 1.5 6.9 2.90E-02 12.51% 4977 10344715 -0.2 0.9 4.5 2.90E-02 12.51% 4978 10434747 Adipoq -0.2 0.8 4.4 2.90E-02 12.51% 4979 10565072 Sec11a 0.2 1.1 9.8 2.90E-02 12.51% 4980 10562905 Atf5 0.3 1.3 8.6 2.90E-02 12.51% 4981 10427418 -0.3 0.8 5.1 2.90E-02 12.51% 4982 10529026 LOC100502829 -0.2 0.9 6.6 2.90E-02 12.51% 4983 10543779 Mir29a -0.2 0.8 3.3 2.90E-02 12.51% 4984 10428366 -0.2 0.9 4.7 2.90E-02 12.52% 4985 10458956 -0.2 0.9 5.8 2.90E-02 12.52% 4986 10407012 Srek1ip1 0.2 1.1 8.5 2.90E-02 12.52% 4987 10506269 Ak4 -0.5 0.7 9.1 2.90E-02 12.52% 4988 10419198 Ero1l 0.2 1.2 9.6 2.90E-02 12.53% 4989 10383982 Znrf3 -0.2 0.9 7.8 2.91E-02 12.53% 4990 10516666 Txlna 0.2 1.2 8.4 2.91E-02 12.53% 4991 10570726 Defa26 -0.3 0.8 6.3 2.91E-02 12.53%

Page 122 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

4992 10436043 -0.3 0.8 4.5 2.91E-02 12.53% 4993 10390945 Krtap4-13 -0.2 0.9 7.0 2.91E-02 12.53% 4994 10357158 Ralb 0.2 1.1 7.6 2.91E-02 12.53% 4995 10416334 Dok2 0.2 1.1 6.6 2.91E-02 12.54% 4996 10457273 Kif5b 0.2 1.1 8.9 2.91E-02 12.54% 4997 10387201 Arhgef15 -0.2 0.9 6.7 2.92E-02 12.55% 4998 10469505 Commd3 0.2 1.1 10.8 2.92E-02 12.55% 4999 10362450 Trdn -0.2 0.8 6.2 2.92E-02 12.55% 5000 10421557 Itm2b -0.1 0.9 12.1 2.92E-02 12.56% 5001 10342692 -0.3 0.8 6.1 2.92E-02 12.56% 5002 10430245 Myh9 0.3 1.3 6.4 2.92E-02 12.57% 5003 10382516 Kctd2 0.2 1.1 8.1 2.92E-02 12.57% 5004 10386963 F930015N05Rik -0.3 0.8 7.0 2.92E-02 12.57% 5005 10501622 Gpr88 -0.3 0.8 5.8 2.93E-02 12.57% 5006 10491730 Rps23 0.2 1.1 9.7 2.93E-02 12.59% 5007 10404053 Hist1h2bc 0.2 1.1 12.3 2.93E-02 12.59% 5008 10403285 Tubal3 -0.2 0.9 4.9 2.93E-02 12.59% 5009 10435832 Gm608 -0.2 0.9 8.8 2.93E-02 12.59% 5010 10353438 Tram2 -0.3 0.8 8.7 2.93E-02 12.59% 5011 10338320 0.3 1.3 7.2 2.93E-02 12.60% 5012 10412900 Nkiras1 0.2 1.2 8.7 2.94E-02 12.60% 5013 10472426 Xirp2 -0.4 0.7 4.4 2.94E-02 12.60% 5014 10489127 Rbl1 0.5 1.4 7.2 2.94E-02 12.60% 5015 10594928 Pigb 0.2 1.1 8.0 2.94E-02 12.60% 5016 10532907 Hnf1a -0.2 0.9 8.7 2.94E-02 12.60% 5017 10342414 -0.4 0.7 7.2 2.94E-02 12.60% 5018 10507903 -0.2 0.9 6.0 2.94E-02 12.61% 5019 10456501 Rnmt 0.3 1.2 6.8 2.94E-02 12.61% 5020 10603387 Hdac6 0.1 1.1 8.0 2.95E-02 12.62% 5021 10588722 Mon1a 0.2 1.1 7.9 2.95E-02 12.62% 5022 10601915 Fam199x 0.2 1.1 7.5 2.95E-02 12.62% 5023 10604602 Mir450b 0.1 1.1 2.6 2.95E-02 12.64% 5024 10541771 Ing4 -0.1 0.9 8.7 2.95E-02 12.64% 5025 10361807 Hivep2 0.2 1.2 7.4 2.95E-02 12.64% 5026 10362861 Scml4 -0.2 0.9 6.3 2.95E-02 12.65% 5027 10576608 -0.2 0.9 5.6 2.96E-02 12.65% 5028 10455761 Prdm6 -0.2 0.9 5.8 2.96E-02 12.65% 5029 10560685 Bcl3 0.4 1.4 8.8 2.96E-02 12.65% 5030 10428074 Rpl30 0.2 1.1 8.1 2.96E-02 12.66% 5031 10342947 0.4 1.3 7.1 2.96E-02 12.66% 5032 10597000 Fbxw13 -0.2 0.9 4.4 2.96E-02 12.67%

Page 123 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5033 10460529 Rin1 -0.2 0.9 6.3 2.97E-02 12.67% 5034 10529142 Ppm1g 0.2 1.2 8.0 2.97E-02 12.67% 5035 10338772 0.3 1.2 7.6 2.97E-02 12.67% 5036 10462140 Dock8 -0.2 0.9 9.4 2.97E-02 12.67% 5037 10350046 Kdm5b 0.2 1.2 8.4 2.97E-02 12.67% 5038 10560592 Clptm1 -0.1 0.9 10.8 2.97E-02 12.67% 5039 10469058 Ucma -0.2 0.9 5.1 2.97E-02 12.68% 5040 10417245 Gm1973 0.2 1.1 4.2 2.97E-02 12.68% 5041 10368762 Cdc40 -0.2 0.9 9.0 2.97E-02 12.68% 5042 10530467 Nfxl1 0.4 1.3 7.6 2.97E-02 12.68% 5043 10469979 Tmem210 -0.2 0.8 6.0 2.98E-02 12.70% 5044 10452442 -0.2 0.9 5.5 2.98E-02 12.70% 5045 10514173 Rpl34 0.1 1.1 11.7 2.98E-02 12.70% 5046 10386205 Olfr323 -0.3 0.8 4.5 2.98E-02 12.70% 5047 10398717 Trmt61a 0.3 1.3 6.7 2.98E-02 12.70% 5048 10348072 -0.2 0.9 6.5 2.98E-02 12.71% 5049 10369828 -0.2 0.9 6.3 2.98E-02 12.71% 5050 10564857 Idh2 0.3 1.2 10.7 2.98E-02 12.71% 5051 10343430 0.4 1.3 4.2 2.98E-02 12.71% 5052 10459614 -0.2 0.9 5.5 2.99E-02 12.71% 5053 10439289 BC117090 -0.4 0.8 4.1 2.99E-02 12.71% 5054 10555907 Olfr678 -0.2 0.9 6.5 2.99E-02 12.72% 5055 10445006 Gm6623 0.3 1.2 8.9 2.99E-02 12.72% 5056 10508012 Rspo1 -0.2 0.9 6.5 2.99E-02 12.72% 5057 10437928 0610037P05Rik 0.2 1.1 8.8 2.99E-02 12.72% 5058 10525983 Ran 0.2 1.2 8.7 2.99E-02 12.72% 5059 10506736 Magoh 0.4 1.3 7.7 2.99E-02 12.72% 5060 10494509 Pias3 0.2 1.2 6.9 2.99E-02 12.72% 5061 10339772 0.4 1.3 8.0 2.99E-02 12.72% 5062 10360863 Mark1 -0.2 0.9 6.2 2.99E-02 12.72% 5063 10605659 0.2 1.1 5.3 3.00E-02 12.72% 5064 10342615 0.7 1.7 4.5 3.00E-02 12.72% 5065 10509620 Capzb 0.2 1.1 9.8 3.00E-02 12.72% 5066 10508805 Wasf2 0.2 1.1 8.8 3.00E-02 12.72% 5067 10343184 -0.5 0.7 6.1 3.00E-02 12.72% 5068 10574213 Ccl22 -0.2 0.9 5.5 3.00E-02 12.72% 5069 10572253 Sugp1 0.3 1.3 7.7 3.00E-02 12.72% 5070 10409065 Ptpdc1 -0.2 0.9 6.4 3.00E-02 12.72% 5071 10409449 F12 -0.2 0.9 11.7 3.00E-02 12.72% 5072 10340488 -0.2 0.9 10.6 3.00E-02 12.72% 5073 10434993 Pigz -0.2 0.9 6.4 3.00E-02 12.72%

Page 124 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5074 10364251 Pofut2 0.2 1.1 7.8 3.00E-02 12.72% 5075 10342369 0.2 1.2 10.1 3.00E-02 12.72% 5076 10571371 Tusc3 0.2 1.1 7.6 3.01E-02 12.74% 5077 10412517 Gm3002 0.3 1.3 5.2 3.01E-02 12.74% 5078 10498119 Frem2 -0.2 0.9 6.1 3.01E-02 12.74% 5079 10484596 0.2 1.1 3.3 3.01E-02 12.74% 5080 10566585 0.4 1.3 6.5 3.01E-02 12.74% 5081 10397083 Rbm25 -0.4 0.7 8.6 3.01E-02 12.75% 5082 10341862 -0.4 0.8 6.2 3.01E-02 12.75% 5083 10424772 -0.2 0.9 7.3 3.01E-02 12.75% 5084 10342552 0.6 1.6 5.2 3.02E-02 12.76% 5085 10399046 Vipr2 -0.3 0.8 5.0 3.02E-02 12.76% 5086 10436428 Mina 0.2 1.1 8.9 3.02E-02 12.76% 5087 10408331 Acot13 -0.2 0.9 10.0 3.02E-02 12.76% 5088 10368647 Dse 0.2 1.2 8.3 3.02E-02 12.76% 5089 10533725 Gpr81 -0.3 0.8 5.8 3.02E-02 12.76% 5090 10572146 Atp6v1b2 0.2 1.1 9.5 3.02E-02 12.77% 5091 10414612 Slc39a2 -0.3 0.8 6.4 3.02E-02 12.77% 5092 10399383 Kcns3 -0.2 0.9 6.7 3.02E-02 12.77% 5093 10434418 Vwa5b2 -0.2 0.9 5.9 3.02E-02 12.77% 5094 10352503 Bpnt1 0.2 1.2 10.7 3.02E-02 12.77% 5095 10339026 0.8 1.8 5.2 3.02E-02 12.77% 5096 10472814 Gm1631 -0.2 0.9 5.8 3.02E-02 12.77% 5097 10445718 Pgc -0.1 0.9 5.8 3.03E-02 12.77% 5098 10413803 Btd 0.2 1.1 9.8 3.03E-02 12.77% 5099 10480633 Slc34a3 -0.2 0.9 6.2 3.03E-02 12.77% 5100 10342142 0.6 1.5 5.0 3.03E-02 12.78% 5101 10543512 Zfp800 0.2 1.1 8.5 3.03E-02 12.78% 5102 10575976 Crispld2 -0.2 0.9 6.5 3.03E-02 12.78% 5103 10400165 Tfb2m -0.2 0.9 9.4 3.03E-02 12.78% 5104 10360185 -0.3 0.8 10.4 3.03E-02 12.78% 5105 10530087 0.1 1.1 3.9 3.03E-02 12.78% 5106 10405835 0.2 1.2 4.9 3.03E-02 12.78% 5107 10395058 Adi1 -0.2 0.8 9.5 3.04E-02 12.79% 5108 10447521 Tfb1m 0.2 1.1 9.4 3.04E-02 12.80% 5109 10338594 0.3 1.2 6.3 3.04E-02 12.80% 5110 10541895 Tnfrsf1a 0.3 1.2 9.3 3.04E-02 12.80% 5111 10343162 -0.6 0.6 4.9 3.04E-02 12.81% 5112 10519667 0.2 1.2 7.7 3.04E-02 12.81% 5113 10583215 Mtmr2 0.1 1.1 9.0 3.04E-02 12.81% 5114 10466848 D19Bwg1357e 0.3 1.2 8.8 3.05E-02 12.81%

Page 125 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5115 10340522 -0.3 0.8 7.1 3.05E-02 12.82% 5116 10339729 0.4 1.3 9.4 3.05E-02 12.82% 5117 10395389 Sostdc1 -0.3 0.8 5.1 3.05E-02 12.82% 5118 10559694 Sbk2 -0.2 0.9 6.2 3.05E-02 12.82% 5119 10606941 Ripply1 0.2 1.1 7.1 3.05E-02 12.82% 5120 10343903 -0.4 0.8 10.1 3.05E-02 12.82% 5121 10384691 0610010F05Rik -0.2 0.9 7.8 3.05E-02 12.82% 5122 10350377 Zbtb41 0.2 1.2 8.2 3.05E-02 12.82% 5123 10411448 Btf3 -0.1 0.9 11.5 3.05E-02 12.82% 5124 10516778 Zcchc17 0.3 1.2 8.4 3.05E-02 12.82% 5125 10348376 Heatr7b1 -0.2 0.9 5.6 3.06E-02 12.82% 5126 10506714 Lrp8 -0.1 0.9 6.1 3.06E-02 12.82% 5127 10563344 Fgf21 -0.2 0.9 5.9 3.06E-02 12.82% 5128 10591754 Zfp599 0.3 1.2 7.1 3.06E-02 12.82% 5129 10562331 Uba2 0.2 1.1 9.3 3.06E-02 12.82% 5130 10378964 Sez6 -0.2 0.9 6.2 3.06E-02 12.82% 5131 10586172 0.5 1.4 6.2 3.06E-02 12.82% 5132 10581395 Slc12a4 0.2 1.1 7.5 3.06E-02 12.82% 5133 10507418 Eif2b3 0.3 1.2 8.3 3.06E-02 12.82% 5134 10502081 Enpep 0.3 1.2 10.2 3.06E-02 12.82% 5135 10567494 -0.2 0.9 4.4 3.06E-02 12.84% 5136 10592471 Gramd1b 0.2 1.1 6.4 3.07E-02 12.84% 5137 10362152 Taar3 -0.2 0.9 4.7 3.07E-02 12.85% 5138 10393728 Slc38a10 0.2 1.1 9.0 3.07E-02 12.85% 5139 10603835 -0.1 0.9 2.9 3.07E-02 12.86% 5140 10389269 Aatf 0.2 1.2 7.7 3.08E-02 12.87% 5141 10454097 Rpl11 0.2 1.1 10.1 3.08E-02 12.87% 5142 10399208 Tmem196 -0.2 0.9 4.3 3.08E-02 12.88% 5143 10395414 Tmem195 -0.2 0.9 11.3 3.08E-02 12.89% 5144 10558971 Ap2a2 0.1 1.1 9.9 3.08E-02 12.89% 5145 10596043 Nck1 0.3 1.2 8.2 3.08E-02 12.89% 5146 10377652 Gps2 0.2 1.1 8.5 3.08E-02 12.89% 5147 10466423 Cep78 0.3 1.2 7.0 3.08E-02 12.89% 5148 10505107 Actl7a -0.2 0.9 5.8 3.08E-02 12.89% 5149 10345411 Arhgef4 -0.2 0.8 6.6 3.09E-02 12.90% 5150 10443383 Lhfpl5 -0.2 0.9 5.7 3.09E-02 12.90% 5151 10479736 Polr3k 0.3 1.2 8.1 3.09E-02 12.90% 5152 10541127 -0.2 0.9 4.5 3.09E-02 12.90% 5153 10562548 C80913 -0.2 0.9 9.1 3.09E-02 12.90% 5154 10571093 Rnf170 -0.4 0.7 9.2 3.09E-02 12.90% 5155 10352980 Sntg1 -0.2 0.9 4.9 3.09E-02 12.90%

Page 126 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5156 10358124 Pkp1 -0.2 0.9 6.2 3.09E-02 12.90% 5157 10550052 Rps5 0.1 1.1 11.9 3.09E-02 12.90% 5158 10424416 -0.2 0.8 7.7 3.10E-02 12.90% 5159 10351689 -0.2 0.9 5.4 3.10E-02 12.90% 5160 10342006 0.4 1.3 6.7 3.10E-02 12.90% 5161 10339387 0.5 1.4 5.8 3.10E-02 12.90% 5162 10574429 -0.2 0.9 5.6 3.10E-02 12.91% 5163 10577824 Letm2 -0.2 0.9 6.7 3.10E-02 12.91% 5164 10342165 0.5 1.4 6.6 3.10E-02 12.91% 5165 10413086 Adk -0.1 0.9 12.1 3.10E-02 12.91% 5166 10358281 -0.2 0.9 3.9 3.10E-02 12.92% 5167 10369276 Ccdc109a 0.2 1.2 8.6 3.11E-02 12.93% 5168 10534021 Rimbp2 -0.2 0.9 5.9 3.11E-02 12.93% 5169 10420030 Psme2 0.2 1.2 10.7 3.11E-02 12.93% 5170 10342852 0.5 1.4 2.8 3.11E-02 12.93% 5171 10342248 -0.4 0.8 5.6 3.11E-02 12.93% 5172 10401924 Rpl31 0.2 1.1 10.7 3.11E-02 12.94% 5173 10604230 Ap3s1 0.2 1.2 9.7 3.11E-02 12.94% 5174 10397557 0.2 1.2 2.6 3.11E-02 12.94% 5175 10343158 0.3 1.3 5.2 3.11E-02 12.94% 5176 10526441 Upk3b -0.5 0.7 6.9 3.11E-02 12.94% 5177 10374106 Ykt6 0.3 1.2 8.7 3.11E-02 12.94% 5178 10407321 -0.2 0.9 3.9 3.12E-02 12.94% 5179 10338213 -0.2 0.9 10.0 3.12E-02 12.94% 5180 10356710 Capn10 -0.2 0.9 6.2 3.12E-02 12.94% 5181 10448967 Sox8 -0.2 0.9 6.6 3.12E-02 12.94% 5182 10363887 Bicc1 -0.2 0.9 4.9 3.12E-02 12.94% 5183 10582896 1.1 2.2 8.8 3.12E-02 12.94% 5184 10343109 -0.5 0.7 6.3 3.12E-02 12.94% 5185 10566372 0.2 1.2 4.4 3.12E-02 12.95% 5186 10339273 0.6 1.5 4.1 3.12E-02 12.95% 5187 10457920 Rps25 0.2 1.1 10.0 3.12E-02 12.95% 5188 10342096 0.2 1.1 11.4 3.12E-02 12.95% 5189 10347417 Bcs1l 0.2 1.1 8.8 3.12E-02 12.95% 5190 10343757 0.6 1.5 4.6 3.13E-02 12.96% 5191 10406777 Gcnt4 -0.4 0.7 6.5 3.13E-02 12.96% 5192 10481900 Rabepk 0.1 1.1 7.3 3.13E-02 12.97% 5193 10502537 Sh3glb1 0.2 1.1 10.3 3.13E-02 12.97% 5194 10401398 2410016O06Rik -0.2 0.9 5.6 3.13E-02 12.97% 5195 10347115 0.2 1.2 2.7 3.13E-02 12.98% 5196 10338872 0.4 1.3 6.8 3.14E-02 12.98%

Page 127 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5197 10453688 0.4 1.3 4.4 3.14E-02 12.98% 5198 10576873 Elavl1 0.2 1.1 9.7 3.14E-02 12.99% 5199 10362171 Stx7 0.2 1.1 7.8 3.14E-02 13.00% 5200 10487629 Idh3b -0.1 0.9 12.0 3.14E-02 13.00% 5201 10564049 0.2 1.1 2.5 3.14E-02 13.00% 5202 10474919 Gm14137 -0.2 0.9 6.3 3.14E-02 13.00% 5203 10340668 -0.4 0.7 6.0 3.15E-02 13.01% 5204 10343744 0.2 1.1 11.1 3.15E-02 13.01% 5205 10465521 Plcb3 0.2 1.1 8.0 3.15E-02 13.01% 5206 10545379 Usp39 0.2 1.1 9.6 3.15E-02 13.01% 5207 10381561 Asb16 -0.2 0.9 6.0 3.15E-02 13.01% 5208 10441456 Synj2 -0.1 0.9 7.1 3.15E-02 13.01% 5209 10340868 0.9 1.9 3.8 3.15E-02 13.01% 5210 10473650 Nup160 0.2 1.2 7.9 3.15E-02 13.01% 5211 10604899 Gm6812 -0.2 0.9 4.9 3.15E-02 13.01% 5212 10343543 -0.3 0.8 7.0 3.15E-02 13.01% 5213 10568536 Cpxm2 -0.2 0.9 5.6 3.15E-02 13.01% 5214 10357381 Ysk4 -0.2 0.9 5.3 3.15E-02 13.01% 5215 10377490 Alox12b -0.2 0.9 5.4 3.15E-02 13.01% 5216 10386211 Fam183b -0.2 0.9 5.2 3.16E-02 13.01% 5217 10513803 -0.2 0.9 5.4 3.16E-02 13.01% 5218 10545130 Gadd45a 0.6 1.5 7.5 3.16E-02 13.02% 5219 10338486 0.4 1.4 7.2 3.16E-02 13.02% 5220 10542596 Slco1c1 -0.2 0.9 5.2 3.16E-02 13.02% 5221 10355730 1810031K17Rik -0.3 0.8 8.1 3.16E-02 13.02% 5222 10532574 Myo18b -0.3 0.8 5.4 3.16E-02 13.03% 5223 10536405 -0.3 0.8 5.8 3.16E-02 13.03% 5224 10600969 Mir676 -0.2 0.9 5.3 3.17E-02 13.04% 5225 10579952 -0.3 0.8 6.4 3.17E-02 13.05% 5226 10544436 Olfr458 -0.2 0.8 5.5 3.17E-02 13.05% 5227 10439409 BC031361 -0.3 0.8 5.1 3.17E-02 13.05% 5228 10600921 Stard8 -0.2 0.9 7.7 3.17E-02 13.05% 5229 10445633 Prph2 -0.3 0.8 5.8 3.17E-02 13.05% 5230 10511721 -0.4 0.8 8.7 3.17E-02 13.05% 5231 10571528 -0.2 0.9 7.4 3.17E-02 13.05% 5232 10427849 6030458C11Rik 0.2 1.2 7.7 3.18E-02 13.05% 5233 10395409 Meox2 -0.2 0.9 4.9 3.18E-02 13.05% 5234 10484205 -0.4 0.8 5.7 3.18E-02 13.05% 5235 10402575 Degs2 -0.3 0.8 5.9 3.18E-02 13.05% 5236 10598229 0.2 1.2 5.4 3.18E-02 13.05% 5237 10408010 Zkscan3 -0.1 0.9 8.1 3.18E-02 13.05%

Page 128 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5238 10532624 Myo18b -0.2 0.8 6.2 3.18E-02 13.06% 5239 10488734 Sun5 -0.1 0.9 5.3 3.18E-02 13.06% 5240 10549025 Slco1a6 -0.2 0.9 4.7 3.18E-02 13.07% 5241 10594490 Slc24a1 -0.2 0.8 6.1 3.18E-02 13.07% 5242 10582890 1.0 2.0 7.8 3.19E-02 13.07% 5243 10513592 Wdr31 -0.2 0.9 5.7 3.19E-02 13.07% 5244 10402096 Ttc7b 0.2 1.1 8.2 3.19E-02 13.07% 5245 10527547 Mtif3 0.1 1.1 8.7 3.19E-02 13.08% 5246 10344484 0.4 1.3 6.2 3.19E-02 13.08% 5247 10529457 Cpz -0.2 0.9 6.5 3.19E-02 13.08% 5248 10450167 Btn3a3 -0.2 0.9 5.9 3.19E-02 13.08% 5249 10471387 Ciz1 0.1 1.1 8.3 3.19E-02 13.08% 5250 10416251 Egr3 -0.2 0.9 7.1 3.19E-02 13.09% 5251 10339010 0.6 1.6 3.0 3.20E-02 13.09% 5252 10591816 Dpy19l1 -0.3 0.8 8.1 3.20E-02 13.09% 5253 10519657 Gm8944 0.2 1.1 8.2 3.20E-02 13.09% 5254 10519684 Gm8944 0.2 1.1 8.2 3.20E-02 13.09% 5255 10606252 -0.2 0.9 7.2 3.20E-02 13.09% 5256 10574033 Nup93 0.3 1.2 7.3 3.20E-02 13.10% 5257 10404630 Riok1 0.3 1.2 6.9 3.20E-02 13.11% 5258 10424670 Hemt1 -0.3 0.8 4.0 3.20E-02 13.11% 5259 10566583 Gm8995 0.3 1.2 7.0 3.21E-02 13.11% 5260 10400479 Nkx2-9 -0.2 0.8 6.5 3.21E-02 13.11% 5261 10556297 Adm 0.2 1.1 6.1 3.21E-02 13.11% 5262 10596465 Acy1 -0.3 0.8 9.7 3.21E-02 13.12% 5263 10339799 0.5 1.4 4.7 3.21E-02 13.12% 5264 10546152 Podxl2 -0.2 0.9 5.7 3.21E-02 13.12% 5265 10590654 Aasdhppt 0.2 1.2 9.0 3.21E-02 13.12% 5266 10389245 Tada2a 0.2 1.1 7.8 3.21E-02 13.12% 5267 10338437 0.2 1.2 10.9 3.21E-02 13.12% 5268 10517703 -0.2 0.8 6.8 3.21E-02 13.12% 5269 10595626 0.5 1.4 7.7 3.22E-02 13.15% 5270 10545974 Antxr1 -0.2 0.9 6.4 3.22E-02 13.15% 5271 10517169 Sh3bgrl3 0.3 1.2 8.3 3.22E-02 13.15% 5272 10417798 Kcnk5 -0.5 0.7 8.7 3.23E-02 13.16% 5273 10534585 Sh2b2 0.2 1.1 7.1 3.23E-02 13.16% 5274 10530287 Apbb2 -0.1 0.9 7.9 3.23E-02 13.16% 5275 10354845 Orc2 0.3 1.2 7.2 3.23E-02 13.16% 5276 10436773 0.2 1.2 6.0 3.23E-02 13.16% 5277 10577866 Ash2l 0.1 1.1 8.9 3.23E-02 13.16% 5278 10344014 -0.6 0.6 3.8 3.23E-02 13.16%

Page 129 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5279 10352794 Gm10516 -0.2 0.9 4.9 3.23E-02 13.16% 5280 10541307 Usp18 0.3 1.2 7.2 3.23E-02 13.17% 5281 10594353 Map2k5 -0.2 0.9 8.1 3.23E-02 13.17% 5282 10560414 Ccdc61 -0.2 0.9 6.7 3.23E-02 13.17% 5283 10590029 -0.2 0.9 5.6 3.23E-02 13.17% 5284 10543959 Ptn -0.2 0.9 5.5 3.24E-02 13.17% 5285 10496756 Mcoln3 -0.2 0.9 5.1 3.24E-02 13.17% 5286 10344417 -0.3 0.8 6.6 3.24E-02 13.18% 5287 10549171 5730419I09Rik 0.4 1.3 7.3 3.24E-02 13.18% 5288 10528721 Galnt11 -0.2 0.8 9.2 3.24E-02 13.18% 5289 10340941 -0.5 0.7 5.4 3.24E-02 13.18% 5290 10419596 Zfp219 0.2 1.1 7.7 3.24E-02 13.18% 5291 10514304 C87499 -0.2 0.8 5.7 3.24E-02 13.18% 5292 10573332 4930432K21Rik -0.2 0.8 5.8 3.24E-02 13.18% 5293 10541729 Cdca3 0.5 1.5 6.8 3.24E-02 13.18% 5294 10597470 Cmtm8 -0.3 0.8 9.6 3.24E-02 13.18% 5295 10525271 Naa25 0.2 1.2 8.5 3.24E-02 13.18% 5296 10347282 Rufy4 -0.2 0.9 6.1 3.25E-02 13.18% 5297 10404316 Prl8a2 0.9 1.9 6.0 3.25E-02 13.18% 5298 10362404 Trdn -0.5 0.7 4.6 3.25E-02 13.18% 5299 10467088 Rpl9 0.1 1.1 11.0 3.25E-02 13.19% 5300 10570644 Gm6040 -0.2 0.9 5.3 3.25E-02 13.19% 5301 10567788 Gsg1l -0.2 0.9 6.7 3.25E-02 13.19% 5302 10515613 Ptprf -0.2 0.9 9.7 3.25E-02 13.19% 5303 10512011 Zfp292 0.3 1.2 9.1 3.25E-02 13.19% 5304 10403193 Sp4 0.4 1.3 7.4 3.26E-02 13.20% 5305 10489092 9830001H06Rik -0.2 0.9 6.4 3.26E-02 13.20% 5306 10568361 Yipf5 0.3 1.2 9.4 3.26E-02 13.20% 5307 10364824 Csnk1g2 -0.2 0.9 9.7 3.26E-02 13.20% 5308 10354494 Nab1 -0.2 0.9 9.6 3.26E-02 13.20% 5309 10573490 Hook2 -0.2 0.9 7.4 3.26E-02 13.21% 5310 10489018 Rbm39 -0.1 0.9 9.8 3.26E-02 13.22% 5311 10528864 Cnpy1 -0.2 0.9 5.5 3.27E-02 13.23% 5312 10391732 Gpatch8 -0.2 0.9 7.1 3.27E-02 13.23% 5313 10560347 -0.1 0.9 4.9 3.27E-02 13.23% 5314 10486322 -0.3 0.8 6.8 3.27E-02 13.23% 5315 10606488 Satl1 -0.2 0.9 4.5 3.27E-02 13.23% 5316 10351825 Tagln2 0.3 1.2 7.9 3.27E-02 13.23% 5317 10540401 Lrrn1 -0.2 0.9 4.8 3.27E-02 13.23% 5318 10567702 Arhgap17 0.2 1.1 7.5 3.27E-02 13.24% 5319 10448214 Zfp944 0.3 1.2 7.1 3.27E-02 13.24%

Page 130 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5320 10416917 Trim52 -0.2 0.9 5.9 3.28E-02 13.25% 5321 10515861 4930538K18Rik -0.2 0.9 4.9 3.28E-02 13.25% 5322 10369485 Col13a1 -0.2 0.9 6.8 3.28E-02 13.25% 5323 10583496 Ppan 0.3 1.3 7.7 3.28E-02 13.26% 5324 10538811 Prdm5 -0.2 0.9 5.8 3.28E-02 13.27% 5325 10599693 Ncrna00086 -0.3 0.8 5.5 3.28E-02 13.27% 5326 10456723 BC031181 0.2 1.2 10.7 3.29E-02 13.27% 5327 10550161 -0.4 0.8 5.2 3.29E-02 13.27% 5328 10429029 Adcy8 -0.2 0.9 4.9 3.29E-02 13.27% 5329 10338572 -0.5 0.7 3.5 3.29E-02 13.27% 5330 10362420 Trdn -0.5 0.7 6.8 3.29E-02 13.27% 5331 10502655 Cyr61 0.4 1.3 8.3 3.29E-02 13.27% 5332 10357535 Pfkfb2 -0.2 0.8 8.2 3.29E-02 13.27% 5333 10514347 Cdkn2b -0.2 0.9 6.1 3.29E-02 13.27% 5334 10549420 Tmtc1 -0.2 0.9 6.3 3.29E-02 13.28% 5335 10354286 Kdelc1 0.2 1.2 6.8 3.29E-02 13.28% 5336 10368644 Fam26f 0.2 1.2 5.9 3.29E-02 13.28% 5337 10446833 Birc6 -0.2 0.9 10.0 3.30E-02 13.28% 5338 10426110 Pim3 -0.3 0.8 8.7 3.30E-02 13.28% 5339 10551215 Rnf170 -0.4 0.7 9.8 3.30E-02 13.28% 5340 10501593 Slc30a7 0.2 1.1 8.8 3.30E-02 13.28% 5341 10515943 Ctps 0.4 1.3 6.5 3.30E-02 13.28% 5342 10534504 Tmem120a 0.2 1.1 8.6 3.30E-02 13.28% 5343 10343032 -0.4 0.8 7.1 3.30E-02 13.28% 5344 10343012 0.4 1.3 6.5 3.30E-02 13.28% 5345 10531203 Adamts3 -0.2 0.8 5.0 3.30E-02 13.28% 5346 10443494 Pi16 -0.2 0.9 5.8 3.30E-02 13.28% 5347 10339456 0.3 1.3 8.5 3.30E-02 13.28% 5348 10410279 -0.2 0.9 6.5 3.30E-02 13.29% 5349 10587776 -0.4 0.8 4.5 3.30E-02 13.29% 5350 10467838 -0.2 0.8 4.1 3.31E-02 13.29% 5351 10358545 Hmcn1 -0.2 0.9 5.3 3.31E-02 13.29% 5352 10473446 Olfr996 0.2 1.1 3.7 3.31E-02 13.29% 5353 10343978 -0.4 0.7 5.1 3.31E-02 13.29% 5354 10341052 0.4 1.3 6.1 3.31E-02 13.29% 5355 10554063 Adamts17 -0.2 0.9 5.6 3.31E-02 13.29% 5356 10478540 Wfdc10 -0.2 0.9 6.4 3.31E-02 13.29% 5357 10343828 -0.3 0.8 7.0 3.31E-02 13.29% 5358 10459705 Smad4 -0.1 0.9 9.6 3.31E-02 13.30% 5359 10555007 -0.3 0.8 7.2 3.31E-02 13.30% 5360 10604674 Gm773 -0.2 0.9 2.9 3.31E-02 13.30%

Page 131 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5361 10401473 Aldh6a1 -0.2 0.9 11.7 3.31E-02 13.30% 5362 10464914 Tmem151a -0.2 0.9 7.0 3.31E-02 13.30% 5363 10371107 Mrpl54 0.2 1.2 8.6 3.32E-02 13.31% 5364 10347650 Accn4 -0.2 0.9 6.3 3.32E-02 13.31% 5365 10412421 Zfp131 0.3 1.2 7.5 3.32E-02 13.31% 5366 10580457 N4bp1 0.2 1.1 8.7 3.32E-02 13.31% 5367 10376446 Trim17 0.2 1.1 6.8 3.32E-02 13.31% 5368 10362729 -0.2 0.9 3.7 3.32E-02 13.31% 5369 10340932 0.4 1.3 7.0 3.32E-02 13.31% 5370 10420390 Xpo4 0.2 1.1 8.0 3.32E-02 13.31% 5371 10577954 Rab11fip1 0.1 1.1 7.4 3.32E-02 13.31% 5372 10413171 0.3 1.2 5.6 3.33E-02 13.31% 5373 10596857 Apeh -0.2 0.9 9.4 3.33E-02 13.31% 5374 10418838 -0.2 0.9 6.6 3.33E-02 13.31% 5375 10349569 -0.4 0.8 4.9 3.33E-02 13.31% 5376 10382316 Kcnj16 -0.2 0.9 5.5 3.33E-02 13.31% 5377 10590323 5830454E08Rik -0.2 0.8 5.9 3.33E-02 13.31% 5378 10511843 1810074P20Rik 0.4 1.3 9.5 3.33E-02 13.31% 5379 10383545 Foxk2 0.2 1.2 8.3 3.33E-02 13.31% 5380 10577349 Defb39 -0.1 0.9 4.0 3.33E-02 13.31% 5381 10353626 -0.2 0.9 13.2 3.33E-02 13.31% 5382 10392261 Smurf2 0.2 1.1 9.7 3.33E-02 13.31% 5383 10391075 Krt42 -0.2 0.9 6.2 3.33E-02 13.31% 5384 10389099 Rad51l3 -0.1 0.9 7.4 3.33E-02 13.31% 5385 10597432 Cnot10 0.2 1.1 8.0 3.33E-02 13.31% 5386 10384210 0.3 1.2 5.8 3.33E-02 13.31% 5387 10538957 0.3 1.2 5.8 3.33E-02 13.31% 5388 10419932 Mir208a 0.2 1.2 4.1 3.34E-02 13.32% 5389 10535381 Actb 0.1 1.1 13.4 3.34E-02 13.32% 5390 10593196 -0.3 0.8 6.5 3.34E-02 13.32% 5391 10344155 -0.4 0.7 6.1 3.34E-02 13.32% 5392 10340247 0.5 1.4 3.1 3.34E-02 13.33% 5393 10338488 -0.3 0.8 8.8 3.34E-02 13.33% 5394 10342032 -0.8 0.6 4.6 3.34E-02 13.33% 5395 10360580 Tfb2m -0.2 0.9 9.4 3.35E-02 13.33% 5396 10476689 LOC668917 -0.2 0.9 6.1 3.35E-02 13.33% 5397 10405147 -0.2 0.8 3.2 3.35E-02 13.33% 5398 10391146 Acly -0.4 0.8 10.0 3.35E-02 13.33% 5399 10495989 Rpl7a 0.1 1.1 11.0 3.35E-02 13.33% 5400 10446224 Crb3 0.2 1.2 7.6 3.35E-02 13.34% 5401 10358654 Hmcn1 -0.2 0.9 6.4 3.35E-02 13.34%

Page 132 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5402 10343264 -0.3 0.8 6.3 3.35E-02 13.34% 5403 10344437 -0.7 0.6 4.8 3.35E-02 13.34% 5404 10476882 -0.2 0.9 6.0 3.35E-02 13.35% 5405 10424662 Psca -0.2 0.9 5.8 3.35E-02 13.35% 5406 10394527 Ttc32 0.3 1.2 7.4 3.36E-02 13.35% 5407 10573624 4921524J17Rik -0.2 0.9 4.0 3.36E-02 13.35% 5408 10338335 0.5 1.4 3.4 3.36E-02 13.35% 5409 10564795 Plin1 -0.2 0.9 6.5 3.36E-02 13.35% 5410 10358523 Hmcn1 -0.2 0.9 6.3 3.36E-02 13.36% 5411 10599001 Agtr2 -0.2 0.9 5.0 3.36E-02 13.36% 5412 10340823 0.3 1.3 8.6 3.36E-02 13.36% 5413 10461057 Rcor2 -0.2 0.9 5.9 3.36E-02 13.36% 5414 10607886 -0.2 0.9 5.3 3.37E-02 13.37% 5415 10402225 Trip11 0.2 1.2 8.0 3.37E-02 13.37% 5416 10483546 0.2 1.2 3.9 3.37E-02 13.38% 5417 10385837 Il13 -0.2 0.9 6.4 3.37E-02 13.38% 5418 10339308 -0.3 0.8 6.4 3.37E-02 13.39% 5419 10604840 -0.2 0.9 6.1 3.37E-02 13.39% 5420 10397052 -0.2 0.9 5.0 3.37E-02 13.39% 5421 10384495 -0.3 0.8 5.1 3.37E-02 13.39% 5422 10607004 Psmd10 0.3 1.2 8.7 3.38E-02 13.40% 5423 10343590 -0.4 0.8 6.8 3.38E-02 13.40% 5424 10342566 -0.3 0.8 9.3 3.38E-02 13.40% 5425 10454154 Dsg3 -0.2 0.9 4.5 3.38E-02 13.40% 5426 10563915 0.2 1.2 2.7 3.38E-02 13.40% 5427 10563929 0.2 1.2 2.7 3.38E-02 13.40% 5428 10451650 Nfya 0.1 1.1 8.1 3.38E-02 13.41% 5429 10352104 -0.4 0.8 7.2 3.39E-02 13.41% 5430 10457378 -0.2 0.9 7.0 3.39E-02 13.41% 5431 10458569 Nr3c1 -0.2 0.9 9.5 3.39E-02 13.41% 5432 10582642 Taf5l 0.2 1.1 7.3 3.39E-02 13.42% 5433 10585091 Nhp2l1 0.2 1.2 10.9 3.39E-02 13.42% 5434 10597477 Gpd1l -0.2 0.8 8.7 3.39E-02 13.42% 5435 10457357 Mpp7 0.3 1.2 6.1 3.39E-02 13.42% 5436 10499095 Fam160a1 -0.2 0.9 6.5 3.39E-02 13.42% 5437 10430920 Tcf20 -0.2 0.9 8.9 3.39E-02 13.42% 5438 10487021 Slc30a4 0.2 1.2 7.9 3.39E-02 13.42% 5439 10442870 Ccdc78 -0.2 0.9 6.2 3.40E-02 13.43% 5440 10596428 Col6a4 -0.3 0.8 6.3 3.40E-02 13.43% 5441 10338304 0.7 1.6 5.1 3.40E-02 13.43% 5442 10508887 Nr0b2 -0.7 0.6 9.0 3.40E-02 13.43%

Page 133 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5443 10557076 Otoa -0.2 0.9 5.4 3.40E-02 13.43% 5444 10402598 Begain -0.2 0.9 5.9 3.40E-02 13.43% 5445 10530787 Aasdh -0.1 0.9 7.1 3.40E-02 13.43% 5446 10498775 Golim4 -0.2 0.9 9.0 3.40E-02 13.44% 5447 10540676 Jagn1 0.2 1.2 9.3 3.40E-02 13.44% 5448 10340431 0.5 1.4 6.4 3.40E-02 13.44% 5449 10338232 0.5 1.4 5.0 3.40E-02 13.44% 5450 10592386 Olfr146 0.3 1.2 3.4 3.41E-02 13.44% 5451 10597898 -0.2 0.9 7.3 3.41E-02 13.44% 5452 10420724 Defb30 -0.2 0.9 6.0 3.41E-02 13.44% 5453 10473363 Timm10 0.2 1.2 7.5 3.41E-02 13.44% 5454 10438256 Gsc2 -0.2 0.9 7.0 3.41E-02 13.45% 5455 10404649 Dsp -0.3 0.8 8.7 3.41E-02 13.46% 5456 10405063 Ogn -0.6 0.7 6.3 3.41E-02 13.46% 5457 10407141 Actbl2 -0.2 0.9 5.4 3.41E-02 13.46% 5458 10422225 0.2 1.2 3.6 3.42E-02 13.46% 5459 10374223 Igfbp1 -1.0 0.5 9.4 3.42E-02 13.47% 5460 10445107 -0.3 0.8 6.5 3.42E-02 13.48% 5461 10344270 0.3 1.2 7.8 3.42E-02 13.48% 5462 10341196 0.4 1.3 6.4 3.42E-02 13.48% 5463 10531972 Gbp8 0.4 1.3 8.4 3.42E-02 13.48% 5464 10507218 Mknk1 0.1 1.1 8.5 3.42E-02 13.48% 5465 10598499 0.2 1.2 9.1 3.43E-02 13.48% 5466 10343102 -0.3 0.8 7.3 3.43E-02 13.48% 5467 10448424 Pdpk1 -0.2 0.9 9.7 3.43E-02 13.48% 5468 10523843 -0.3 0.8 8.0 3.43E-02 13.48% 5469 10516064 Mfsd2a -1.1 0.5 10.3 3.43E-02 13.48% 5470 10384219 -0.3 0.8 5.0 3.43E-02 13.48% 5471 10566209 Olfr601 -0.2 0.9 5.3 3.43E-02 13.48% 5472 10343234 -0.2 0.9 7.2 3.43E-02 13.48% 5473 10393881 Mafg -0.2 0.9 8.7 3.43E-02 13.48% 5474 10550730 Zfp296 -0.2 0.9 6.1 3.43E-02 13.48% 5475 10550638 Rtn2 -0.3 0.8 5.6 3.43E-02 13.48% 5476 10339951 0.6 1.6 5.9 3.43E-02 13.48% 5477 10340204 -0.3 0.8 5.2 3.43E-02 13.48% 5478 10577057 1700016D06Rik -0.2 0.9 3.7 3.43E-02 13.48% 5479 10580484 Heatr3 -0.2 0.9 7.5 3.43E-02 13.48% 5480 10580188 Nacc1 0.2 1.1 8.3 3.44E-02 13.49% 5481 10513381 Rod1 -0.1 0.9 11.2 3.44E-02 13.49% 5482 10376482 2310033P09Rik -0.1 0.9 7.9 3.44E-02 13.49% 5483 10549256 Kras 0.3 1.2 8.5 3.44E-02 13.50%

Page 134 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5484 10402715 Bag5 0.2 1.2 7.6 3.44E-02 13.51% 5485 10343253 0.3 1.2 10.2 3.45E-02 13.51% 5486 10381187 Atp6v0a1 -0.2 0.9 9.7 3.45E-02 13.51% 5487 10519012 Arhgef16 -0.2 0.9 6.1 3.45E-02 13.51% 5488 10516051 Cap1 0.1 1.1 10.6 3.45E-02 13.51% 5489 10359518 Eif4e1b -0.2 0.9 6.2 3.45E-02 13.51% 5490 10598232 -0.2 0.9 7.0 3.45E-02 13.51% 5491 10343815 0.5 1.4 6.6 3.45E-02 13.51% 5492 10454077 Taf4b 0.3 1.2 6.6 3.45E-02 13.51% 5493 10341789 -0.4 0.8 7.2 3.45E-02 13.51% 5494 10490194 -0.2 0.9 6.7 3.45E-02 13.52% 5495 10439303 Casr -0.2 0.9 5.9 3.45E-02 13.52% 5496 10520860 -0.2 0.8 4.4 3.46E-02 13.54% 5497 10341795 0.6 1.5 5.2 3.46E-02 13.54% 5498 10357003 Rnf152 -0.3 0.8 7.3 3.46E-02 13.55% 5499 10340230 -0.4 0.8 9.0 3.47E-02 13.57% 5500 10455461 Myot -0.6 0.6 5.9 3.47E-02 13.57% 5501 10403868 0.2 1.2 6.9 3.47E-02 13.58% 5502 10592878 Upk2 -0.2 0.9 6.6 3.47E-02 13.58% 5503 10497935 0.3 1.2 2.9 3.47E-02 13.58% 5504 10525555 Mlxip -0.1 0.9 7.4 3.48E-02 13.59% 5505 10365003 Snord37 0.4 1.3 5.5 3.48E-02 13.59% 5506 10566595 Olfr697 -0.2 0.8 5.2 3.48E-02 13.59% 5507 10456184 Apcdd1 -0.2 0.9 6.3 3.48E-02 13.59% 5508 10342717 0.1 1.1 12.0 3.48E-02 13.59% 5509 10424779 Cks2 0.3 1.2 9.4 3.48E-02 13.59% 5510 10485597 Depdc7 0.2 1.2 8.9 3.48E-02 13.59% 5511 10454877 Pura -0.1 0.9 10.3 3.48E-02 13.59% 5512 10552796 Tsks -0.2 0.9 6.7 3.49E-02 13.60% 5513 10396079 Klhdc1 -0.2 0.9 4.9 3.49E-02 13.60% 5514 10351968 Olfr220 -0.2 0.9 5.0 3.49E-02 13.60% 5515 10394931 2410018L13Rik -0.3 0.8 4.8 3.49E-02 13.60% 5516 10494664 Wars2 0.1 1.1 7.6 3.49E-02 13.60% 5517 10346323 Mars2 0.2 1.1 7.0 3.49E-02 13.60% 5518 10401781 Sptlc2 0.2 1.2 8.8 3.49E-02 13.60% 5519 10430071 Recql4 -0.2 0.9 6.3 3.49E-02 13.62% 5520 10409992 -0.3 0.8 5.4 3.50E-02 13.62% 5521 10382980 Syngr2 -0.1 0.9 10.6 3.50E-02 13.62% 5522 10343892 0.4 1.3 5.3 3.50E-02 13.63% 5523 10578120 -0.2 0.9 5.3 3.50E-02 13.63% 5524 10552632 Shank1 -0.2 0.9 5.5 3.50E-02 13.63%

Page 135 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5525 10495878 Ndst4 -0.3 0.8 4.2 3.50E-02 13.63% 5526 10460461 Rbm4b -0.2 0.9 8.6 3.50E-02 13.63% 5527 10352864 -0.3 0.8 5.6 3.50E-02 13.63% 5528 10344320 -0.5 0.7 6.5 3.51E-02 13.64% 5529 10419267 Cnih 0.2 1.1 10.6 3.51E-02 13.64% 5530 10541268 Slc25a18 -0.2 0.8 6.0 3.51E-02 13.64% 5531 10546452 Adamts9 -0.2 0.9 7.1 3.51E-02 13.64% 5532 10465980 Sdhaf2 0.2 1.2 8.8 3.51E-02 13.64% 5533 10416566 Epsti1 0.2 1.2 6.4 3.51E-02 13.64% 5534 10608642 Defa-rs12 -0.2 0.9 6.8 3.51E-02 13.64% 5535 10426157 Trabd 0.3 1.2 9.0 3.51E-02 13.65% 5536 10453026 Prkd3 -0.3 0.8 9.2 3.52E-02 13.66% 5537 10408741 Txndc5 0.2 1.2 10.2 3.52E-02 13.66% 5538 10575144 Nip7 0.2 1.2 7.4 3.52E-02 13.66% 5539 10414081 Syt15 -0.1 0.9 6.4 3.52E-02 13.66% 5540 10398404 Mir667 -0.2 0.9 8.4 3.52E-02 13.66% 5541 10382104 Snord104 0.4 1.3 12.8 3.52E-02 13.66% 5542 10339553 -0.3 0.8 7.4 3.52E-02 13.66% 5543 10338747 0.7 1.6 4.4 3.52E-02 13.66% 5544 10581013 Cdh11 -0.2 0.8 5.4 3.52E-02 13.66% 5545 10593103 Rnf214 -0.2 0.9 8.5 3.52E-02 13.66% 5546 10505919 -0.2 0.9 6.7 3.52E-02 13.66% 5547 10517147 Dhdds 0.2 1.1 8.7 3.52E-02 13.67% 5548 10380654 Hoxb3 -0.2 0.9 6.7 3.53E-02 13.67% 5549 10342763 -0.2 0.9 12.8 3.53E-02 13.67% 5550 10485989 Aqr 0.2 1.1 9.0 3.53E-02 13.67% 5551 10542764 Arntl2 -0.2 0.9 5.1 3.53E-02 13.67% 5552 10408168 Abt1 0.1 1.1 7.6 3.53E-02 13.68% 5553 10503283 1110037F02Rik 0.2 1.1 8.3 3.53E-02 13.69% 5554 10344304 -0.4 0.8 6.8 3.54E-02 13.69% 5555 10426689 Spats2 0.2 1.2 7.1 3.54E-02 13.70% 5556 10522696 Arl9 -0.2 0.9 5.3 3.54E-02 13.70% 5557 10342082 0.7 1.6 4.5 3.54E-02 13.70% 5558 10363641 Herc4 -0.1 0.9 9.2 3.54E-02 13.70% 5559 10417568 Oit1 -0.3 0.8 5.0 3.54E-02 13.71% 5560 10440721 Krtap16-7 -0.3 0.8 4.9 3.54E-02 13.71% 5561 10338353 -0.4 0.8 7.2 3.55E-02 13.72% 5562 10587211 Leo1 0.2 1.1 6.6 3.55E-02 13.72% 5563 10401128 Max 0.2 1.1 8.6 3.55E-02 13.73% 5564 10469613 Thnsl1 0.2 1.1 6.1 3.55E-02 13.74% 5565 10486396 Ehd4 0.3 1.2 7.2 3.56E-02 13.75%

Page 136 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5566 10389222 Ccl6 0.5 1.4 8.0 3.56E-02 13.75% 5567 10476910 Cst12 -0.2 0.9 3.5 3.56E-02 13.75% 5568 10478326 Sgk2 0.5 1.5 9.2 3.56E-02 13.75% 5569 10338610 0.5 1.4 5.9 3.56E-02 13.75% 5570 10567851 Nfatc2ip 0.2 1.1 6.2 3.56E-02 13.75% 5571 10486320 -0.2 0.9 7.1 3.56E-02 13.75% 5572 10594340 Skor1 -0.2 0.9 5.2 3.56E-02 13.75% 5573 10534456 Hip1 0.2 1.1 7.2 3.56E-02 13.75% 5574 10477218 Ttll9 -0.2 0.9 6.0 3.56E-02 13.75% 5575 10341118 0.5 1.5 5.1 3.56E-02 13.75% 5576 10382532 Slc16a5 0.3 1.3 8.4 3.56E-02 13.75% 5577 10523297 Ccng2 -0.4 0.7 7.3 3.57E-02 13.75% 5578 10480275 Nebl -0.2 0.9 5.7 3.57E-02 13.75% 5579 10550274 Meis3 -0.1 0.9 6.4 3.57E-02 13.75% 5580 10339804 0.2 1.2 6.2 3.57E-02 13.75% 5581 10383763 -0.3 0.8 7.2 3.57E-02 13.75% 5582 10374430 Wdr92 0.2 1.1 7.6 3.57E-02 13.75% 5583 10419458 Olfr749 0.2 1.2 3.0 3.57E-02 13.75% 5584 10527880 C030048B08Rik 0.2 1.1 7.2 3.57E-02 13.75% 5585 10510399 Masp2 -0.1 0.9 11.8 3.57E-02 13.75% 5586 10596322 1700080E11Rik -0.2 0.9 5.5 3.57E-02 13.75% 5587 10467344 Noc3l 0.3 1.2 7.8 3.57E-02 13.75% 5588 10579181 Rfxank 0.1 1.1 7.5 3.57E-02 13.75% 5589 10408762 Eef1e1 0.3 1.3 9.1 3.57E-02 13.75% 5590 10502419 Rap1gds1 0.2 1.1 7.9 3.57E-02 13.75% 5591 10530683 Chic2 -0.3 0.8 10.2 3.57E-02 13.75% 5592 10417759 Ube2e2 0.3 1.2 9.4 3.57E-02 13.75% 5593 10437673 Tnp2 -0.2 0.9 5.3 3.58E-02 13.75% 5594 10362104 Slc2a12 -0.3 0.8 5.2 3.58E-02 13.76% 5595 10466120 Ms4a15 -0.2 0.8 6.7 3.58E-02 13.77% 5596 10341222 0.4 1.3 7.0 3.58E-02 13.77% 5597 10578690 Neil3 0.5 1.4 5.8 3.59E-02 13.78% 5598 10394593 Fam49a 0.3 1.2 7.5 3.59E-02 13.78% 5599 10421863 Pcdh8 -0.2 0.9 5.7 3.59E-02 13.78% 5600 10344407 0.5 1.4 4.2 3.59E-02 13.79% 5601 10424691 Ly6f 0.4 1.3 7.3 3.59E-02 13.79% 5602 10566427 Olfr684 -0.3 0.8 3.5 3.60E-02 13.81% 5603 10493247 Ubqln4 0.2 1.2 8.5 3.60E-02 13.81% 5604 10479058 1700021F07Rik -0.2 0.9 6.8 3.60E-02 13.81% 5605 10548051 Kcna6 -0.2 0.9 5.3 3.60E-02 13.81% 5606 10339690 -0.5 0.7 7.1 3.60E-02 13.81%

Page 137 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5607 10607259 Tro -0.2 0.9 5.6 3.60E-02 13.81% 5608 10414487 Olfr744 -0.3 0.8 5.3 3.60E-02 13.81% 5609 10547056 Tmem40 -0.2 0.9 6.0 3.60E-02 13.81% 5610 10360202 Nhlh1 -0.2 0.9 5.0 3.60E-02 13.82% 5611 10358476 Prg4 0.5 1.4 10.5 3.60E-02 13.82% 5612 10551966 Hspb6 -0.3 0.8 8.1 3.61E-02 13.84% 5613 10527832 Pds5b -0.2 0.9 8.6 3.61E-02 13.84% 5614 10540287 -0.2 0.9 6.0 3.61E-02 13.84% 5615 10521415 Ablim2 -0.2 0.9 7.0 3.61E-02 13.84% 5616 10574226 Ccl17 -0.2 0.9 5.6 3.61E-02 13.84% 5617 10417310 -0.1 0.9 5.2 3.61E-02 13.84% 5618 10415844 Ctsb 0.1 1.1 11.9 3.62E-02 13.84% 5619 10588195 -0.2 0.9 5.8 3.62E-02 13.86% 5620 10525751 Ddx55 0.2 1.2 6.9 3.62E-02 13.86% 5621 10416195 Nkx3-1 -0.2 0.9 5.4 3.62E-02 13.86% 5622 10557060 -0.3 0.8 5.5 3.62E-02 13.86% 5623 10560505 Ckm -0.2 0.9 6.6 3.62E-02 13.86% 5624 10542834 Gm5887 -0.2 0.9 6.2 3.63E-02 13.87% 5625 10413185 Zmiz1 0.3 1.2 8.9 3.63E-02 13.87% 5626 10414811 -0.2 0.9 4.3 3.63E-02 13.87% 5627 10414937 -0.2 0.9 4.3 3.63E-02 13.87% 5628 10435980 Rps24 0.2 1.1 9.0 3.63E-02 13.87% 5629 10339601 0.4 1.3 6.2 3.63E-02 13.87% 5630 10497622 Lrrc34 0.1 1.1 4.2 3.63E-02 13.89% 5631 10340792 -0.5 0.7 6.1 3.63E-02 13.89% 5632 10565002 Crtc3 0.2 1.1 7.7 3.64E-02 13.89% 5633 10461305 B3gat3 0.2 1.1 8.4 3.64E-02 13.89% 5634 10393341 Rhbdf2 0.2 1.1 7.4 3.64E-02 13.89% 5635 10343729 0.5 1.4 6.6 3.64E-02 13.89% 5636 10491704 Spata5 0.3 1.3 7.4 3.64E-02 13.89% 5637 10403984 Vmn1r194 -0.2 0.8 4.7 3.64E-02 13.89% 5638 10571891 Aadat -0.2 0.9 10.3 3.64E-02 13.90% 5639 10421730 AU021034 -0.2 0.9 5.2 3.64E-02 13.90% 5640 10339245 0.3 1.2 9.2 3.65E-02 13.91% 5641 10481320 Gtf3c4 0.2 1.1 7.7 3.65E-02 13.91% 5642 10340607 -0.5 0.7 8.4 3.65E-02 13.91% 5643 10473547 Srp9 0.3 1.2 10.6 3.65E-02 13.91% 5644 10582916 1.0 2.0 8.5 3.65E-02 13.91% 5645 10496159 Ints12 0.2 1.2 8.8 3.65E-02 13.92% 5646 10378785 Bhlha9 -0.2 0.9 5.8 3.65E-02 13.92% 5647 10511298 9430015G10Rik -0.2 0.9 7.7 3.65E-02 13.92%

Page 138 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5648 10395049 Rnaseh1 0.2 1.1 6.8 3.66E-02 13.92% 5649 10533929 Scarb1 -0.2 0.9 10.3 3.66E-02 13.92% 5650 10523206 Uso1 0.3 1.2 10.1 3.66E-02 13.92% 5651 10511330 Mos -0.2 0.9 5.2 3.66E-02 13.92% 5652 10584653 C1qtnf5 -0.2 0.9 6.8 3.66E-02 13.92% 5653 10596680 Sema3b -0.2 0.9 6.2 3.66E-02 13.93% 5654 10537426 -0.1 0.9 6.0 3.66E-02 13.93% 5655 10338845 -0.4 0.7 6.2 3.66E-02 13.93% 5656 10370608 -0.4 0.8 3.0 3.66E-02 13.93% 5657 10599736 Fhl1 -0.4 0.8 7.9 3.66E-02 13.93% 5658 10424929 Adck5 0.2 1.2 8.1 3.67E-02 13.93% 5659 10342170 0.3 1.2 10.3 3.67E-02 13.93% 5660 10340732 -0.5 0.7 5.8 3.67E-02 13.94% 5661 10460696 Slc25a45 0.3 1.2 9.4 3.67E-02 13.94% 5662 10552574 Klk1b26 0.2 1.1 5.6 3.67E-02 13.95% 5663 10338400 0.3 1.3 8.3 3.68E-02 13.96% 5664 10457733 B4galt6 0.2 1.2 6.2 3.68E-02 13.97% 5665 10530633 Sgcb 0.2 1.1 6.3 3.68E-02 13.97% 5666 10340308 0.4 1.3 6.7 3.68E-02 13.97% 5667 10340694 -0.3 0.8 7.3 3.68E-02 13.97% 5668 10458415 -0.2 0.8 6.5 3.68E-02 13.97% 5669 10339703 0.5 1.4 4.8 3.68E-02 13.97% 5670 10364441 Vmn2r83 -0.2 0.9 4.2 3.68E-02 13.97% 5671 10521555 Lyar 0.2 1.2 7.2 3.68E-02 13.97% 5672 10521356 Hgfac 0.2 1.2 10.1 3.68E-02 13.97% 5673 10606369 Itm2a -0.5 0.7 5.3 3.69E-02 13.97% 5674 10343850 0.7 1.7 4.7 3.69E-02 13.97% 5675 10468893 Csf2ra 0.2 1.2 7.9 3.69E-02 13.98% 5676 10341124 -0.5 0.7 5.8 3.69E-02 13.98% 5677 10542636 Pyroxd1 0.2 1.1 8.0 3.69E-02 13.98% 5678 10544941 Pde1c -0.1 0.9 5.9 3.69E-02 13.98% 5679 10363639 Atoh7 -0.2 0.9 7.9 3.69E-02 13.98% 5680 10341618 0.6 1.5 5.7 3.69E-02 13.99% 5681 10436758 Gm10229 -0.2 0.9 4.1 3.69E-02 13.99% 5682 10396466 1700086L19Rik -0.2 0.9 4.8 3.70E-02 13.99% 5683 10444997 2410017I17Rik -0.2 0.9 5.7 3.70E-02 14.00% 5684 10418185 D14Ertd449e -0.2 0.9 10.6 3.70E-02 14.00% 5685 10343024 -0.3 0.8 8.9 3.70E-02 14.00% 5686 10573549 Fbxw9 0.1 1.1 7.8 3.70E-02 14.01% 5687 10351867 Aim2 0.3 1.2 6.5 3.70E-02 14.01% 5688 10339055 0.4 1.3 5.7 3.71E-02 14.02%

Page 139 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5689 10369210 Serinc1 -0.1 0.9 11.6 3.71E-02 14.02% 5690 10445879 Kcnh8 -0.2 0.9 5.4 3.71E-02 14.02% 5691 10569200 Polr2l 0.2 1.1 10.3 3.71E-02 14.02% 5692 10421806 Zfp957 -0.2 0.8 5.9 3.71E-02 14.02% 5693 10418198 D14Ertd449e -0.2 0.9 10.6 3.71E-02 14.02% 5694 10576692 Insr -0.2 0.9 10.9 3.71E-02 14.02% 5695 10513945 2310002L09Rik -0.2 0.9 5.0 3.71E-02 14.03% 5696 10599377 Stag2 -0.2 0.8 8.5 3.71E-02 14.03% 5697 10430574 4933432B09Rik -0.2 0.9 5.5 3.71E-02 14.03% 5698 10342817 -0.5 0.7 4.9 3.72E-02 14.03% 5699 10367717 BC013529 0.3 1.2 9.3 3.72E-02 14.04% 5700 10373709 Eif4enif1 0.1 1.1 7.7 3.72E-02 14.04% 5701 10342967 0.2 1.1 10.3 3.72E-02 14.04% 5702 10452609 Lrrc30 -0.3 0.8 6.1 3.72E-02 14.04% 5703 10520696 -0.2 0.9 5.9 3.72E-02 14.04% 5704 10469289 Il15ra -0.2 0.9 9.2 3.72E-02 14.04% 5705 10590096 Dlec1 -0.2 0.9 6.3 3.72E-02 14.04% 5706 10343277 0.8 1.7 4.5 3.72E-02 14.04% 5707 10489305 Ptprt -0.1 0.9 6.1 3.73E-02 14.05% 5708 10377055 Myh2 -0.7 0.6 5.7 3.73E-02 14.05% 5709 10396610 Mthfd1 -0.2 0.9 10.9 3.73E-02 14.05% 5710 10341598 -0.7 0.6 3.1 3.73E-02 14.05% 5711 10385993 Anxa6 -0.2 0.9 6.5 3.73E-02 14.06% 5712 10481420 D2Wsu81e 0.1 1.1 8.2 3.73E-02 14.06% 5713 10500347 BC107364 -0.3 0.8 5.0 3.74E-02 14.07% 5714 10347948 Sp100 0.3 1.2 7.5 3.74E-02 14.07% 5715 10552540 Klk15 -0.2 0.8 5.8 3.74E-02 14.07% 5716 10411508 Ptcd2 0.2 1.2 8.6 3.75E-02 14.09% 5717 10420853 Pnoc -0.2 0.9 6.5 3.75E-02 14.09% 5718 10431170 5031439G07Rik 0.2 1.2 9.2 3.75E-02 14.09% 5719 10341924 0.6 1.5 6.0 3.75E-02 14.09% 5720 10341000 0.5 1.4 8.1 3.75E-02 14.09% 5721 10341702 -0.7 0.6 3.2 3.75E-02 14.09% 5722 10554005 H47 0.3 1.3 9.1 3.75E-02 14.09% 5723 10515003 Fam159a -0.2 0.9 6.1 3.75E-02 14.09% 5724 10562649 -0.3 0.8 10.4 3.75E-02 14.09% 5725 10485800 Olfr1308 0.2 1.2 2.8 3.75E-02 14.09% 5726 10574944 Dus2l 0.3 1.2 7.9 3.75E-02 14.09% 5727 10383055 Cbx2 -0.2 0.9 7.6 3.75E-02 14.09% 5728 10453734 -0.2 0.9 6.8 3.76E-02 14.10% 5729 10339174 0.2 1.2 7.6 3.76E-02 14.10%

Page 140 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5730 10451322 Cul9 -0.2 0.9 6.8 3.76E-02 14.10% 5731 10338549 0.5 1.4 3.2 3.76E-02 14.10% 5732 10377429 Snord118 0.7 1.6 7.4 3.76E-02 14.11% 5733 10399428 Snord118 0.7 1.6 7.4 3.76E-02 14.11% 5734 10445826 Mocs1 -0.3 0.8 10.0 3.76E-02 14.11% 5735 10554547 0.3 1.2 4.2 3.76E-02 14.11% 5736 10343160 0.5 1.5 4.2 3.76E-02 14.11% 5737 10340349 0.5 1.4 4.8 3.76E-02 14.11% 5738 10468159 Ldb1 -0.2 0.9 9.5 3.76E-02 14.11% 5739 10338757 -0.3 0.8 7.4 3.76E-02 14.11% 5740 10545101 Hpgds 0.3 1.2 5.9 3.76E-02 14.11% 5741 10395807 1110008L16Rik 0.2 1.1 9.2 3.76E-02 14.11% 5742 10343616 0.5 1.4 5.7 3.77E-02 14.12% 5743 10522060 Fam114a1 0.2 1.2 8.9 3.77E-02 14.12% 5744 10503654 -0.2 0.8 5.4 3.77E-02 14.12% 5745 10393239 -0.2 0.9 6.4 3.77E-02 14.12% 5746 10357590 Dyrk3 -0.3 0.8 6.6 3.77E-02 14.12% 5747 10380392 Spata20 -0.2 0.9 6.0 3.77E-02 14.12% 5748 10592850 Trappc4 0.2 1.2 8.8 3.77E-02 14.12% 5749 10522606 Exoc1 0.2 1.1 7.7 3.78E-02 14.12% 5750 10411082 Thbs4 -0.2 0.9 5.7 3.78E-02 14.12% 5751 10344591 0.4 1.3 7.0 3.78E-02 14.12% 5752 10560752 Vmn1r125 0.3 1.2 4.3 3.78E-02 14.12% 5753 10473180 Ppp1r1c -0.2 0.9 5.1 3.78E-02 14.12% 5754 10555844 Olfr646 -0.2 0.9 5.5 3.78E-02 14.12% 5755 10445514 Dlk2 -0.2 0.9 6.8 3.78E-02 14.12% 5756 10500009 Rpl31 0.2 1.1 10.8 3.78E-02 14.12% 5757 10530128 3110047P20Rik -0.2 0.9 7.1 3.78E-02 14.12% 5758 10345409 -0.2 0.9 6.4 3.78E-02 14.12% 5759 10347254 Smarcal1 0.2 1.1 7.9 3.78E-02 14.12% 5760 10559728 -0.2 0.9 3.8 3.78E-02 14.12% 5761 10344335 -0.6 0.7 5.7 3.78E-02 14.12% 5762 10414211 Mbl1 0.3 1.2 10.9 3.78E-02 14.12% 5763 10339759 -0.2 0.9 11.3 3.79E-02 14.13% 5764 10420899 Gulo -0.2 0.9 11.8 3.79E-02 14.13% 5765 10387029 Dnahc9 -0.1 0.9 5.5 3.79E-02 14.13% 5766 10580678 Ces1g -0.2 0.8 11.8 3.79E-02 14.13% 5767 10574184 Rspry1 0.2 1.1 8.3 3.79E-02 14.13% 5768 10498446 0.2 1.2 5.1 3.79E-02 14.13% 5769 10417713 Rarb 0.4 1.3 8.6 3.79E-02 14.13% 5770 10414703 -0.1 0.9 6.9 3.79E-02 14.13%

Page 141 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5771 10369911 1110038D17Rik -0.2 0.9 9.9 3.79E-02 14.13% 5772 10410214 0.2 1.1 2.2 3.79E-02 14.13% 5773 10366229 Lin7a -0.2 0.9 9.8 3.79E-02 14.13% 5774 10344501 -1.3 0.4 4.3 3.79E-02 14.13% 5775 10343621 0.3 1.2 8.9 3.79E-02 14.13% 5776 10339869 0.3 1.2 6.0 3.79E-02 14.13% 5777 10549282 Itpr2 -0.2 0.9 9.3 3.79E-02 14.13% 5778 10415645 Mrp63 0.2 1.1 9.2 3.80E-02 14.13% 5779 10373628 Olfr798 -0.4 0.8 3.0 3.80E-02 14.13% 5780 10590462 Mir138-1 -0.2 0.9 6.5 3.80E-02 14.13% 5781 10578623 Wwc2 0.1 1.1 7.7 3.80E-02 14.13% 5782 10596093 -0.2 0.9 6.9 3.80E-02 14.13% 5783 10339124 0.4 1.3 6.0 3.80E-02 14.13% 5784 10562397 -0.3 0.8 8.7 3.80E-02 14.14% 5785 10394733 Rps23 0.2 1.1 9.6 3.80E-02 14.15% 5786 10453553 -0.2 0.9 6.6 3.81E-02 14.15% 5787 10481056 Notch1 -0.2 0.9 8.4 3.81E-02 14.15% 5788 10459089 Ndst1 -0.2 0.9 10.5 3.81E-02 14.15% 5789 10419594 Rnase13 -0.2 0.9 5.4 3.81E-02 14.15% 5790 10598407 0.2 1.2 4.6 3.81E-02 14.15% 5791 10582882 0.9 1.8 9.6 3.81E-02 14.16% 5792 10519124 Gabrd -0.2 0.9 6.0 3.81E-02 14.16% 5793 10369877 Ube2d1 0.2 1.2 9.3 3.81E-02 14.16% 5794 10495530 Dph5 0.2 1.1 7.8 3.82E-02 14.17% 5795 10351852 Crp 0.2 1.2 12.4 3.82E-02 14.17% 5796 10429341 Ptk2 0.2 1.1 8.4 3.82E-02 14.18% 5797 10427883 Acot10 0.3 1.2 5.3 3.82E-02 14.18% 5798 10516246 Cdca8 0.3 1.3 5.9 3.82E-02 14.18% 5799 10529154 Nrbp1 -0.2 0.9 7.0 3.82E-02 14.18% 5800 10382788 Galr2 -0.2 0.9 5.6 3.82E-02 14.18% 5801 10543895 2010107G12Rik -0.2 0.9 5.7 3.82E-02 14.18% 5802 10344350 -0.4 0.8 7.3 3.83E-02 14.18% 5803 10475080 Mapkbp1 0.2 1.1 6.5 3.83E-02 14.18% 5804 10583472 Pin1 0.1 1.1 6.9 3.83E-02 14.18% 5805 10344342 0.5 1.4 7.1 3.83E-02 14.18% 5806 10507983 Epha10 -0.2 0.9 6.7 3.83E-02 14.18% 5807 10476886 Sstr4 -0.2 0.9 6.4 3.83E-02 14.18% 5808 10410460 Ube2ql1 -0.4 0.8 7.1 3.84E-02 14.20% 5809 10499529 Slc50a1 0.2 1.1 9.2 3.84E-02 14.20% 5810 10385533 Tgtp1 0.6 1.5 7.6 3.84E-02 14.20% 5811 10449756 Hsf2bp -0.2 0.9 5.6 3.84E-02 14.20%

Page 142 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5812 10339466 0.6 1.6 3.3 3.84E-02 14.20% 5813 10396867 Exd2 -0.2 0.9 7.7 3.84E-02 14.20% 5814 10563085 Fcgrt -0.2 0.9 10.9 3.84E-02 14.20% 5815 10521848 Zcchc4 0.1 1.1 7.6 3.84E-02 14.20% 5816 10361799 Adat2 0.2 1.1 8.1 3.84E-02 14.20% 5817 10471385 Mir199b -0.2 0.9 4.4 3.84E-02 14.20% 5818 10536425 -0.2 0.9 6.0 3.84E-02 14.20% 5819 10590269 Mobp -0.1 0.9 5.7 3.84E-02 14.20% 5820 10572815 Tmem38a -0.2 0.9 5.9 3.84E-02 14.20% 5821 10386033 Fat2 -0.2 0.9 5.9 3.84E-02 14.20% 5822 10545502 Dnahc6 -0.2 0.9 4.3 3.84E-02 14.20% 5823 10343981 0.5 1.4 6.8 3.85E-02 14.21% 5824 10443091 -0.2 0.9 6.8 3.85E-02 14.21% 5825 10484624 Olfr1086 -0.2 0.9 4.8 3.85E-02 14.21% 5826 10484584 -0.2 0.9 5.0 3.85E-02 14.21% 5827 10505109 BC026590 0.2 1.2 7.5 3.85E-02 14.21% 5828 10595441 Rpl7a 0.1 1.1 11.2 3.85E-02 14.21% 5829 10406546 -0.2 0.9 5.6 3.85E-02 14.21% 5830 10585444 Ireb2 -0.2 0.9 10.1 3.85E-02 14.22% 5831 10455647 Tnfaip8 0.2 1.1 6.3 3.86E-02 14.22% 5832 10363696 D630028G08Rik -0.2 0.9 4.6 3.86E-02 14.22% 5833 10357077 Serpinb3d -0.2 0.9 3.3 3.86E-02 14.23% 5834 10414926 -0.2 0.9 4.2 3.86E-02 14.23% 5835 10414728 -0.2 0.9 4.2 3.86E-02 14.23% 5836 10419154 Ear1 0.2 1.2 5.2 3.86E-02 14.23% 5837 10496555 Gbp1 0.6 1.5 6.9 3.86E-02 14.23% 5838 10446307 0.1 1.1 2.4 3.86E-02 14.23% 5839 10556031 Olfr704 0.2 1.2 3.4 3.86E-02 14.23% 5840 10451851 Armcx3 0.4 1.3 7.7 3.87E-02 14.24% 5841 10360806 Capn2 0.2 1.1 8.7 3.87E-02 14.24% 5842 10584428 Olfr912 0.2 1.2 3.1 3.87E-02 14.25% 5843 10343851 0.4 1.3 4.6 3.87E-02 14.25% 5844 10543772 Klf14 -0.2 0.8 7.6 3.87E-02 14.25% 5845 10463265 Cnnm1 -0.2 0.9 6.3 3.87E-02 14.25% 5846 10559392 Zc3h3 -0.1 0.9 7.0 3.87E-02 14.25% 5847 10339104 -0.2 0.9 8.6 3.87E-02 14.25% 5848 10403392 -0.3 0.8 4.9 3.87E-02 14.25% 5849 10450224 -0.2 0.9 8.6 3.88E-02 14.25% 5850 10442231 3110052M02Rik 0.3 1.2 7.0 3.88E-02 14.25% 5851 10544995 Vmn1r16 0.1 1.1 2.8 3.88E-02 14.25% 5852 10366803 Cyp27b1 -0.2 0.9 5.5 3.88E-02 14.25%

Page 143 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5853 10414767 Rps19 0.2 1.1 8.4 3.88E-02 14.25% 5854 10414874 Rps19 0.2 1.1 8.4 3.88E-02 14.25% 5855 10425999 Ttc38 -0.3 0.8 9.8 3.88E-02 14.25% 5856 10566613 0.3 1.2 3.3 3.88E-02 14.25% 5857 10410351 AA987161 0.3 1.2 8.1 3.88E-02 14.25% 5858 10374453 Glul -0.2 0.9 11.9 3.88E-02 14.25% 5859 10419364 0.3 1.2 2.8 3.88E-02 14.26% 5860 10384656 B3gnt2 0.2 1.2 7.5 3.88E-02 14.26% 5861 10451670 Tspo2 -0.2 0.9 5.3 3.89E-02 14.26% 5862 10518464 2610109H07Rik -0.2 0.9 6.5 3.89E-02 14.26% 5863 10559095 Muc5b -0.1 0.9 5.8 3.89E-02 14.27% 5864 10444853 Pou5f1 -0.3 0.8 5.0 3.89E-02 14.27% 5865 10488299 Gm14092 -0.2 0.9 3.6 3.89E-02 14.27% 5866 10524004 Pcgf3 -0.2 0.9 8.5 3.89E-02 14.27% 5867 10475027 Tyro3 -0.2 0.9 6.4 3.89E-02 14.27% 5868 10378349 Trpv1 -0.2 0.9 5.2 3.89E-02 14.27% 5869 10607619 Cdkl5 0.2 1.2 7.8 3.89E-02 14.28% 5870 10363007 Ascc3 0.2 1.1 9.2 3.90E-02 14.28% 5871 10339926 -0.4 0.8 7.0 3.90E-02 14.28% 5872 10440617 -0.3 0.8 4.0 3.90E-02 14.28% 5873 10352554 -0.2 0.9 6.2 3.90E-02 14.29% 5874 10343197 -0.6 0.7 3.0 3.90E-02 14.29% 5875 10447668 Gm1604b -0.2 0.9 6.5 3.90E-02 14.29% 5876 10390103 Pdk2 -0.3 0.8 10.3 3.90E-02 14.29% 5877 10567498 -0.2 0.9 5.1 3.91E-02 14.29% 5878 10496592 Gbp2 0.4 1.3 6.9 3.91E-02 14.29% 5879 10510980 -0.2 0.8 6.6 3.91E-02 14.30% 5880 10539813 Ccdc48 -0.2 0.9 7.2 3.91E-02 14.31% 5881 10377851 Psmb6 0.1 1.1 10.3 3.91E-02 14.31% 5882 10570011 -0.2 0.9 5.0 3.91E-02 14.31% 5883 10488449 0.3 1.2 7.1 3.91E-02 14.31% 5884 10552708 Kcnc3 -0.2 0.9 6.2 3.91E-02 14.31% 5885 10371271 Zfp781 0.2 1.2 6.8 3.92E-02 14.31% 5886 10410317 Zfp459 0.3 1.2 5.7 3.92E-02 14.31% 5887 10379190 Vtn 0.1 1.1 13.5 3.92E-02 14.31% 5888 10479274 Cdh4 -0.2 0.9 6.9 3.92E-02 14.31% 5889 10457380 0.2 1.2 6.4 3.92E-02 14.31% 5890 10340618 0.3 1.2 6.9 3.92E-02 14.31% 5891 10461396 Scgb2a2 -0.3 0.8 4.0 3.92E-02 14.31% 5892 10357051 Kdsr 0.2 1.2 9.8 3.92E-02 14.31% 5893 10359870 Pbx1 -0.2 0.9 7.8 3.92E-02 14.31%

Page 144 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5894 10341439 -0.3 0.8 7.7 3.92E-02 14.31% 5895 10545672 Mthfd2 0.3 1.2 6.7 3.92E-02 14.31% 5896 10575596 -0.3 0.8 7.0 3.92E-02 14.31% 5897 10571005 Letm2 -0.2 0.9 6.6 3.92E-02 14.31% 5898 10503204 Chd7 -0.1 0.9 8.2 3.92E-02 14.31% 5899 10342518 -0.3 0.8 8.5 3.92E-02 14.31% 5900 10470305 Rpl7a 0.1 1.1 11.1 3.93E-02 14.31% 5901 10580622 Ces1b -0.2 0.9 12.1 3.93E-02 14.31% 5902 10373569 Rpsa 0.2 1.2 10.4 3.93E-02 14.31% 5903 10569646 Ccnd1 0.3 1.2 11.0 3.93E-02 14.31% 5904 10437677 Prm3 -0.2 0.9 6.9 3.93E-02 14.31% 5905 10494945 Syt6 -0.2 0.9 6.5 3.93E-02 14.31% 5906 10385932 Lyrm7 -0.2 0.9 5.3 3.93E-02 14.32% 5907 10338985 0.4 1.4 5.7 3.93E-02 14.33% 5908 10380566 Phospho1 -0.2 0.9 6.0 3.94E-02 14.33% 5909 10408227 Hfe 0.2 1.1 8.2 3.94E-02 14.34% 5910 10373740 Pik3ip1 -0.2 0.9 6.4 3.94E-02 14.34% 5911 10587208 Bcl2l10 -0.2 0.9 4.7 3.94E-02 14.34% 5912 10460123 9330132A10Rik 0.1 1.1 3.0 3.94E-02 14.34% 5913 10520371 Rbm33 -0.2 0.9 9.4 3.94E-02 14.35% 5914 10342038 -0.6 0.6 5.9 3.95E-02 14.35% 5915 10476252 Cdc25b 0.2 1.1 6.4 3.95E-02 14.35% 5916 10530960 Tmprss11d 0.1 1.1 4.2 3.95E-02 14.35% 5917 10538206 Ccdc126 0.2 1.2 6.2 3.95E-02 14.35% 5918 10455602 Dmxl1 0.2 1.1 9.5 3.95E-02 14.36% 5919 10597258 Tmie 0.1 1.1 6.9 3.96E-02 14.38% 5920 10339683 -0.4 0.7 6.1 3.96E-02 14.38% 5921 10360695 Nvl 0.2 1.2 8.0 3.96E-02 14.38% 5922 10552656 Syt3 -0.2 0.9 6.6 3.96E-02 14.38% 5923 10343000 -0.4 0.8 6.2 3.96E-02 14.38% 5924 10471419 Naif1 0.2 1.1 6.9 3.96E-02 14.38% 5925 10343895 0.3 1.2 8.1 3.96E-02 14.38% 5926 10380289 Mmd 0.3 1.2 10.9 3.96E-02 14.38% 5927 10354777 Satb2 0.2 1.1 5.7 3.96E-02 14.38% 5928 10516859 Ythdf2 0.2 1.1 8.2 3.96E-02 14.38% 5929 10339572 0.4 1.4 6.1 3.97E-02 14.39% 5930 10442683 Ptx4 -0.2 0.8 4.8 3.97E-02 14.39% 5931 10344400 -0.3 0.8 7.8 3.97E-02 14.39% 5932 10435388 Adcy5 -0.1 0.9 6.1 3.97E-02 14.39% 5933 10407435 Akr1c18 0.3 1.2 5.1 3.97E-02 14.39% 5934 10339160 -0.3 0.8 7.6 3.97E-02 14.40%

Page 145 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5935 10531724 Plac8 0.5 1.4 6.8 3.98E-02 14.41% 5936 10521566 Tmem128 0.2 1.1 8.1 3.98E-02 14.41% 5937 10499358 Bglap2 -0.2 0.9 6.4 3.98E-02 14.42% 5938 10350758 A930039A15Rik -0.3 0.8 7.3 3.98E-02 14.42% 5939 10344213 0.4 1.3 6.0 3.99E-02 14.43% 5940 10549875 Olfr1350 -0.2 0.9 5.3 3.99E-02 14.43% 5941 10472289 Tank 0.3 1.2 8.7 3.99E-02 14.43% 5942 10394680 0.2 1.2 6.9 3.99E-02 14.43% 5943 10606195 Rlim 0.2 1.1 8.7 3.99E-02 14.44% 5944 10375360 Ebf1 -0.2 0.8 5.3 3.99E-02 14.44% 5945 10543879 Wdr91 -0.2 0.9 7.7 3.99E-02 14.44% 5946 10349945 -0.3 0.8 6.4 3.99E-02 14.44% 5947 10349932 Etnk2 -0.3 0.8 10.0 4.00E-02 14.45% 5948 10363281 Ranbp2 0.2 1.1 9.6 4.00E-02 14.47% 5949 10411853 Erbb2ip -0.1 0.9 10.0 4.00E-02 14.47% 5950 10488233 -0.2 0.9 7.1 4.00E-02 14.47% 5951 10339280 -0.5 0.7 3.0 4.00E-02 14.47% 5952 10408882 Ranbp9 0.2 1.1 9.0 4.00E-02 14.47% 5953 10338829 0.4 1.4 7.0 4.01E-02 14.48% 5954 10342914 0.4 1.3 7.5 4.01E-02 14.48% 5955 10490569 Kcnq2 -0.1 0.9 5.6 4.01E-02 14.48% 5956 10511368 Impad1 -0.2 0.9 8.7 4.01E-02 14.48% 5957 10577164 Gas6 0.6 1.5 9.1 4.01E-02 14.48% 5958 10561008 Ceacam1 -0.2 0.9 11.7 4.01E-02 14.48% 5959 10568496 4933402N03Rik -0.2 0.9 4.8 4.01E-02 14.48% 5960 10539805 -0.2 0.9 5.5 4.01E-02 14.48% 5961 10377308 Mfsd6l -0.2 0.9 6.3 4.01E-02 14.48% 5962 10404129 Lrrc16a -0.2 0.9 5.5 4.02E-02 14.49% 5963 10477725 Mmp24 -0.2 0.9 6.4 4.02E-02 14.49% 5964 10558410 Ptpre 0.1 1.1 6.1 4.02E-02 14.49% 5965 10339117 -0.2 0.8 7.3 4.02E-02 14.50% 5966 10570013 Abhd13 0.2 1.1 8.6 4.02E-02 14.50% 5967 10450363 Snord52 0.6 1.5 5.5 4.02E-02 14.50% 5968 10597913 1110059G10Rik 0.3 1.3 7.1 4.03E-02 14.50% 5969 10344209 -0.3 0.8 7.4 4.03E-02 14.50% 5970 10587637 Tbx18 -0.2 0.9 7.7 4.03E-02 14.50% 5971 10375234 Nudcd2 0.3 1.3 8.4 4.03E-02 14.50% 5972 10455104 Pcdhb15 -0.2 0.9 6.0 4.03E-02 14.51% 5973 10374727 Bcl11a -0.2 0.9 6.5 4.03E-02 14.51% 5974 10588931 BC048562 -0.2 0.9 5.7 4.03E-02 14.51% 5975 10343807 0.3 1.3 6.9 4.03E-02 14.51%

Page 146 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

5976 10438681 Kng2 0.1 1.1 12.7 4.04E-02 14.53% 5977 10576524 Gm505 0.2 1.1 7.0 4.04E-02 14.53% 5978 10338606 -0.4 0.7 6.4 4.04E-02 14.53% 5979 10340763 0.4 1.3 5.5 4.04E-02 14.54% 5980 10407222 Dhx29 0.2 1.2 7.7 4.04E-02 14.54% 5981 10531177 Adamts3 -0.2 0.9 5.6 4.04E-02 14.54% 5982 10508382 Ak2 -0.2 0.9 10.8 4.04E-02 14.54% 5983 10588755 Camkv -0.2 0.9 5.7 4.04E-02 14.54% 5984 10466837 -0.2 0.9 5.9 4.05E-02 14.54% 5985 10452188 Mllt1 0.2 1.1 8.3 4.05E-02 14.54% 5986 10518197 Gm13125 -0.3 0.8 5.2 4.05E-02 14.54% 5987 10440918 Tmem50b 0.3 1.2 9.2 4.05E-02 14.56% 5988 10526630 Trfr2 0.2 1.1 10.6 4.05E-02 14.57% 5989 10501608 Vcam1 0.3 1.2 8.0 4.06E-02 14.57% 5990 10346141 0.2 1.1 3.4 4.06E-02 14.57% 5991 10493903 Lce3c -0.2 0.9 7.7 4.06E-02 14.57% 5992 10513200 Txndc8 -0.2 0.8 4.9 4.06E-02 14.57% 5993 10550605 Eml2 -0.1 0.9 7.3 4.06E-02 14.57% 5994 10403579 Prl2c5 0.5 1.4 3.8 4.06E-02 14.57% 5995 10563110 Snord34 0.9 1.8 7.5 4.06E-02 14.57% 5996 10340471 0.4 1.4 5.0 4.06E-02 14.58% 5997 10513020 Ikbkap 0.2 1.1 7.6 4.07E-02 14.58% 5998 10537791 Olfr453 -0.2 0.9 5.1 4.07E-02 14.58% 5999 10499470 Rusc1 0.2 1.1 7.3 4.07E-02 14.58% 6000 10362097 H60b 0.2 1.1 4.5 4.07E-02 14.59% 6001 10444591 Hspa1l -0.2 0.9 6.0 4.07E-02 14.59% 6002 10428517 Csmd3 -0.2 0.9 4.2 4.07E-02 14.59% 6003 10358057 Shisa4 -0.2 0.9 6.4 4.07E-02 14.59% 6004 10339064 -0.2 0.9 10.6 4.07E-02 14.59% 6005 10340183 -0.4 0.8 6.3 4.08E-02 14.60% 6006 10504337 Car9 -0.2 0.9 5.4 4.08E-02 14.60% 6007 10384266 -0.2 0.9 5.4 4.08E-02 14.60% 6008 10409044 -0.2 0.9 5.9 4.08E-02 14.60% 6009 10505925 0.2 1.1 7.1 4.08E-02 14.61% 6010 10343146 -0.3 0.8 10.9 4.08E-02 14.61% 6011 10339445 0.3 1.2 2.4 4.08E-02 14.61% 6012 10450798 -0.2 0.9 4.0 4.08E-02 14.61% 6013 10461115 Slc22a8 -0.2 0.8 6.2 4.09E-02 14.61% 6014 10478962 2010011I20Rik -0.3 0.8 9.6 4.09E-02 14.61% 6015 10560443 Gipr -0.2 0.9 6.1 4.09E-02 14.62% 6016 10599174 Il13ra1 0.2 1.2 10.7 4.09E-02 14.62%

Page 147 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6017 10447551 5730437N04Rik 0.2 1.1 9.8 4.09E-02 14.62% 6018 10542722 Rps25 0.1 1.1 11.3 4.09E-02 14.62% 6019 10458555 Spry4 -0.5 0.7 7.8 4.09E-02 14.62% 6020 10401335 Med6 0.3 1.2 9.4 4.10E-02 14.63% 6021 10421717 Gm1587 -0.2 0.9 5.6 4.10E-02 14.64% 6022 10433885 Cebpd -0.2 0.9 5.6 4.10E-02 14.65% 6023 10391990 1700081L11Rik -0.1 0.9 8.1 4.10E-02 14.65% 6024 10501555 Amy1 -0.2 0.9 11.2 4.10E-02 14.65% 6025 10345206 -0.2 0.9 6.1 4.10E-02 14.65% 6026 10378497 Mnt -0.1 0.9 7.4 4.10E-02 14.65% 6027 10509410 Rap1gap -0.1 0.9 6.1 4.11E-02 14.65% 6028 10401181 Rdh11 -0.3 0.8 9.4 4.11E-02 14.65% 6029 10428209 -0.2 0.9 4.5 4.11E-02 14.65% 6030 10344364 -0.3 0.8 8.8 4.11E-02 14.65% 6031 10397866 Golga5 0.2 1.1 7.9 4.11E-02 14.66% 6032 10466794 Fam122a 0.2 1.1 7.1 4.11E-02 14.66% 6033 10551852 Clip3 -0.2 0.9 6.3 4.11E-02 14.67% 6034 10547869 Leprel2 -0.2 0.9 7.0 4.12E-02 14.67% 6035 10599863 -0.2 0.9 3.6 4.12E-02 14.67% 6036 10383708 Rnf185 0.2 1.2 8.4 4.12E-02 14.67% 6037 10598187 0.2 1.1 5.6 4.12E-02 14.67% 6038 10543052 Rps27a 0.2 1.1 7.5 4.12E-02 14.67% 6039 10347734 Sgpp2 -0.2 0.9 6.0 4.12E-02 14.68% 6040 10343199 -0.5 0.7 5.6 4.12E-02 14.68% 6041 10408838 Elovl2 -0.2 0.8 11.7 4.12E-02 14.68% 6042 10486191 Ppp1r14d -0.2 0.8 5.9 4.12E-02 14.68% 6043 10341869 0.4 1.4 2.8 4.13E-02 14.68% 6044 10339420 -0.4 0.8 5.4 4.13E-02 14.69% 6045 10380341 Spag9 -0.2 0.9 9.2 4.13E-02 14.69% 6046 10450564 Gtf2h4 0.1 1.1 8.1 4.13E-02 14.69% 6047 10380641 Hoxb5 -0.2 0.9 5.8 4.13E-02 14.69% 6048 10587042 Rsl24d1 0.2 1.2 8.6 4.13E-02 14.70% 6049 10344291 -0.8 0.6 3.1 4.13E-02 14.70% 6050 10558220 Pstk 0.2 1.1 7.1 4.13E-02 14.70% 6051 10419872 Ppp1r3e -0.2 0.9 7.1 4.13E-02 14.70% 6052 10410625 Sdha -0.1 0.9 11.8 4.14E-02 14.71% 6053 10415279 Fitm1 0.5 1.4 8.6 4.14E-02 14.71% 6054 10576034 Irf8 0.2 1.1 7.7 4.14E-02 14.71% 6055 10596303 Acpp -0.2 0.9 5.4 4.15E-02 14.73% 6056 10576797 0.2 1.2 7.1 4.15E-02 14.73% 6057 10606333 Fndc3c1 -0.2 0.9 4.5 4.15E-02 14.73%

Page 148 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6058 10608689 LOC790956 0.3 1.3 10.5 4.15E-02 14.73% 6059 10393373 St6galnac1 -0.3 0.8 5.4 4.15E-02 14.73% 6060 10420694 Ints6 0.2 1.1 8.8 4.15E-02 14.74% 6061 10341976 0.4 1.3 4.9 4.15E-02 14.74% 6062 10342021 0.3 1.2 10.4 4.15E-02 14.74% 6063 10483789 Evx2 -0.2 0.9 7.6 4.16E-02 14.75% 6064 10340875 -0.6 0.6 5.9 4.16E-02 14.75% 6065 10355500 Igfbp5 0.7 1.6 8.2 4.16E-02 14.75% 6066 10342222 -0.3 0.8 9.8 4.16E-02 14.75% 6067 10341156 -0.3 0.8 6.5 4.16E-02 14.75% 6068 10559420 Tmc4 -0.2 0.9 7.0 4.16E-02 14.75% 6069 10499954 Lce1m -0.2 0.9 5.9 4.16E-02 14.75% 6070 10409396 Uimc1 0.2 1.1 8.0 4.16E-02 14.75% 6071 10367224 Stat2 0.2 1.2 9.1 4.16E-02 14.75% 6072 10569611 Fadd 0.2 1.1 7.6 4.16E-02 14.75% 6073 10353034 Snord87 0.7 1.6 6.2 4.17E-02 14.77% 6074 10401416 2410016O06Rik -0.2 0.9 7.0 4.17E-02 14.77% 6075 10543921 Slc13a4 -0.3 0.8 6.5 4.17E-02 14.77% 6076 10525916 -0.2 0.8 6.8 4.17E-02 14.77% 6077 10341605 0.3 1.2 7.4 4.17E-02 14.77% 6078 10592140 Ddx25 -0.2 0.9 4.3 4.17E-02 14.77% 6079 10501222 Gstm2 0.2 1.2 10.1 4.17E-02 14.77% 6080 10339582 0.2 1.2 7.2 4.18E-02 14.77% 6081 10561128 Cyp2s1 -0.2 0.9 6.4 4.18E-02 14.77% 6082 10529824 Prom1 0.5 1.4 7.3 4.18E-02 14.78% 6083 10358050 Timm17a 0.3 1.2 9.2 4.18E-02 14.78% 6084 10400844 Pygl -0.2 0.9 10.5 4.18E-02 14.78% 6085 10533071 Suds3 -0.2 0.9 10.2 4.18E-02 14.79% 6086 10488185 Bfsp1 -0.2 0.9 6.0 4.19E-02 14.79% 6087 10341809 0.3 1.3 3.0 4.19E-02 14.79% 6088 10498168 Exosc8 0.3 1.2 9.1 4.19E-02 14.80% 6089 10562461 C230052I12Rik 0.2 1.2 7.0 4.19E-02 14.80% 6090 10389842 Utp18 0.4 1.3 7.6 4.19E-02 14.80% 6091 10343855 0.5 1.4 5.7 4.19E-02 14.80% 6092 10350766 Stx6 0.1 1.1 7.5 4.19E-02 14.80% 6093 10581835 Wdr59 -0.1 0.9 8.3 4.19E-02 14.80% 6094 10473509 Olfr1094 0.2 1.1 3.0 4.19E-02 14.80% 6095 10343285 -0.3 0.8 7.6 4.19E-02 14.80% 6096 10503401 Tmem55a 0.1 1.1 8.2 4.20E-02 14.80% 6097 10597575 Plcd1 -0.2 0.9 6.0 4.20E-02 14.80% 6098 10453939 Lama3 -0.1 0.9 6.1 4.20E-02 14.80%

Page 149 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6099 10504634 E230008N13Rik -0.2 0.9 3.0 4.20E-02 14.80% 6100 10453736 Unkl 0.2 1.2 8.4 4.20E-02 14.80% 6101 10582884 0.7 1.6 5.4 4.20E-02 14.81% 6102 10583535 Icam5 -0.2 0.9 6.2 4.20E-02 14.81% 6103 10377087 Myh1 -0.8 0.6 5.1 4.20E-02 14.81% 6104 10588026 Rpl7a 0.1 1.1 11.4 4.21E-02 14.81% 6105 10489372 0610008F07Rik 0.6 1.5 8.3 4.21E-02 14.81% 6106 10578681 -0.2 0.9 9.9 4.21E-02 14.81% 6107 10368981 Lin28b -0.2 0.9 4.5 4.21E-02 14.81% 6108 10583416 0.2 1.2 4.4 4.21E-02 14.81% 6109 10429426 -0.2 0.9 7.1 4.21E-02 14.81% 6110 10340041 -0.4 0.8 6.6 4.21E-02 14.81% 6111 10391518 Mpp3 -0.1 0.9 5.9 4.21E-02 14.81% 6112 10343617 0.4 1.3 6.3 4.21E-02 14.81% 6113 10470959 Phyhd1 -0.2 0.9 10.5 4.21E-02 14.81% 6114 10564237 -0.2 0.9 4.2 4.21E-02 14.81% 6115 10580829 Cngb1 -0.1 0.9 5.4 4.21E-02 14.81% 6116 10343326 0.5 1.4 3.6 4.21E-02 14.81% 6117 10364696 Atp5d -0.1 0.9 13.1 4.21E-02 14.82% 6118 10380551 Phb -0.2 0.9 9.9 4.22E-02 14.82% 6119 10450731 -0.4 0.7 5.2 4.22E-02 14.83% 6120 10343410 0.6 1.5 7.2 4.22E-02 14.84% 6121 10524684 Msi1 -0.2 0.8 6.1 4.22E-02 14.84% 6122 10343510 0.4 1.4 3.3 4.23E-02 14.84% 6123 10563643 Tsg101 0.2 1.1 9.4 4.23E-02 14.84% 6124 10532313 AB010352 0.3 1.2 4.6 4.23E-02 14.84% 6125 10342477 0.7 1.6 2.8 4.23E-02 14.84% 6126 10398569 Zfp839 -0.2 0.9 6.7 4.23E-02 14.84% 6127 10388465 Doc2b -0.2 0.9 5.7 4.23E-02 14.84% 6128 10575685 Nudt7 -0.3 0.8 11.3 4.23E-02 14.84% 6129 10364194 Lss -0.3 0.8 9.3 4.23E-02 14.84% 6130 10372889 BC048403 -0.3 0.8 5.9 4.23E-02 14.84% 6131 10570585 0.2 1.1 3.7 4.23E-02 14.84% 6132 10344495 -0.2 0.9 11.9 4.23E-02 14.84% 6133 10522075 Klhl5 0.1 1.1 8.2 4.23E-02 14.85% 6134 10344271 -0.5 0.7 4.9 4.24E-02 14.85% 6135 10343494 0.7 1.6 8.6 4.24E-02 14.86% 6136 10466903 4430402I18Rik 0.2 1.2 6.0 4.24E-02 14.86% 6137 10458283 -0.2 0.9 7.0 4.24E-02 14.87% 6138 10439068 Osta -0.2 0.9 5.2 4.24E-02 14.87% 6139 10540984 Rho -0.2 0.9 5.2 4.24E-02 14.87%

Page 150 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6140 10340852 0.4 1.3 6.2 4.25E-02 14.87% 6141 10594480 Rab11a 0.2 1.1 9.1 4.25E-02 14.87% 6142 10589870 0.2 1.1 4.9 4.25E-02 14.87% 6143 10340201 0.5 1.4 6.0 4.25E-02 14.87% 6144 10445803 Unc5cl -0.2 0.9 5.8 4.25E-02 14.88% 6145 10562166 Hamp2 -0.6 0.7 11.0 4.25E-02 14.88% 6146 10351507 -0.2 0.9 4.9 4.25E-02 14.88% 6147 10447315 -0.2 0.8 5.6 4.25E-02 14.88% 6148 10360761 -0.2 0.9 5.2 4.25E-02 14.88% 6149 10343096 -0.5 0.7 4.9 4.25E-02 14.88% 6150 10338461 -0.7 0.6 6.4 4.26E-02 14.88% 6151 10534912 6430598A04Rik -0.2 0.9 6.0 4.26E-02 14.88% 6152 10574151 Nlrc5 0.2 1.2 6.8 4.26E-02 14.88% 6153 10343749 1.1 2.1 6.3 4.26E-02 14.88% 6154 10588081 Foxl2 -0.2 0.9 6.0 4.26E-02 14.88% 6155 10574899 Nutf2 0.2 1.2 7.9 4.26E-02 14.88% 6156 10546088 H1fx -0.2 0.9 6.5 4.26E-02 14.88% 6157 10511490 -0.2 0.9 4.5 4.26E-02 14.88% 6158 10549079 Gys2 -0.4 0.8 11.2 4.26E-02 14.89% 6159 10430358 C1qtnf6 -0.2 0.9 5.8 4.26E-02 14.89% 6160 10492021 Postn -0.3 0.8 6.9 4.26E-02 14.89% 6161 10512915 2810432L12Rik -0.2 0.9 5.6 4.26E-02 14.89% 6162 10375975 Zcchc10 0.3 1.3 6.4 4.27E-02 14.89% 6163 10390430 Srcin1 -0.2 0.9 6.2 4.27E-02 14.89% 6164 10479423 Col9a3 -0.2 0.8 7.4 4.27E-02 14.89% 6165 10343489 -0.3 0.8 6.6 4.27E-02 14.89% 6166 10340773 0.7 1.7 6.2 4.27E-02 14.90% 6167 10534152 Wbscr17 -0.2 0.9 5.7 4.27E-02 14.90% 6168 10524450 Ung 0.2 1.2 7.3 4.27E-02 14.90% 6169 10355246 Acadl 0.2 1.1 11.1 4.27E-02 14.90% 6170 10490119 Gcnt7 -0.2 0.8 6.3 4.27E-02 14.90% 6171 10585201 Timm8b 0.1 1.1 10.2 4.28E-02 14.91% 6172 10561369 BC089491 -0.3 0.8 5.4 4.28E-02 14.91% 6173 10404000 Vmn1r201 0.2 1.2 2.7 4.28E-02 14.91% 6174 10344387 -0.4 0.8 10.5 4.28E-02 14.91% 6175 10589004 Qars 0.1 1.1 9.4 4.28E-02 14.92% 6176 10557035 Polr3e 0.2 1.1 7.7 4.28E-02 14.92% 6177 10478421 Kcnk15 -0.2 0.9 6.9 4.28E-02 14.92% 6178 10541214 B4galnt3 -0.3 0.8 5.6 4.29E-02 14.92% 6179 10340886 -0.6 0.7 6.1 4.29E-02 14.93% 6180 10580169 Ccdc130 0.2 1.1 7.9 4.29E-02 14.93%

Page 151 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6181 10445867 Plcl2 0.1 1.1 8.0 4.29E-02 14.94% 6182 10341914 0.5 1.5 3.8 4.29E-02 14.94% 6183 10367544 Ctdsp2 -0.2 0.9 9.0 4.29E-02 14.94% 6184 10568532 Rpl7a 0.1 1.1 11.2 4.30E-02 14.94% 6185 10497376 -0.2 0.9 4.8 4.30E-02 14.94% 6186 10342951 -0.3 0.8 7.0 4.30E-02 14.94% 6187 10439239 Dirc2 -0.3 0.8 8.8 4.30E-02 14.94% 6188 10367073 Snrpd2 0.2 1.1 8.9 4.30E-02 14.94% 6189 10590909 Endod1 0.3 1.2 6.6 4.30E-02 14.94% 6190 10361098 Nenf 0.1 1.1 6.8 4.30E-02 14.94% 6191 10407416 Calml3 -0.2 0.9 5.3 4.30E-02 14.94% 6192 10576726 Rps23 0.2 1.1 10.0 4.30E-02 14.95% 6193 10603172 Rpl7a 0.1 1.1 11.2 4.30E-02 14.95% 6194 10584700 Dpagt1 0.3 1.2 9.5 4.31E-02 14.96% 6195 10556769 Acsm3 -0.2 0.9 10.4 4.31E-02 14.96% 6196 10546137 Abtb1 -0.2 0.9 7.8 4.31E-02 14.97% 6197 10566454 Prkcdbp -0.2 0.9 6.8 4.31E-02 14.97% 6198 10339062 0.3 1.2 10.1 4.31E-02 14.97% 6199 10339058 0.6 1.5 4.0 4.31E-02 14.97% 6200 10367598 -0.2 0.9 6.5 4.32E-02 14.97% 6201 10557285 Lcmt1 0.2 1.1 7.8 4.32E-02 14.97% 6202 10379006 Dhrs13 -0.1 0.9 6.2 4.32E-02 14.97% 6203 10342942 0.5 1.4 7.4 4.32E-02 14.97% 6204 10506415 Oma1 0.2 1.1 8.3 4.32E-02 14.97% 6205 10480090 Itga8 -0.3 0.8 7.3 4.32E-02 14.97% 6206 10485361 B230118H07Rik 0.2 1.1 5.8 4.32E-02 14.97% 6207 10430174 Apol9a 0.3 1.2 9.3 4.32E-02 14.97% 6208 10562601 -0.2 0.9 5.3 4.32E-02 14.97% 6209 10367772 Samd5 -0.2 0.9 6.6 4.32E-02 14.97% 6210 10382345 Cog1 0.2 1.1 8.4 4.32E-02 14.97% 6211 10553430 Slc6a5 -0.2 0.9 5.6 4.32E-02 14.97% 6212 10392152 Scn4a -0.2 0.9 5.8 4.32E-02 14.97% 6213 10366401 -0.2 0.9 4.4 4.32E-02 14.97% 6214 10339343 0.3 1.2 2.4 4.33E-02 14.99% 6215 10399973 Hdac9 0.3 1.2 5.8 4.33E-02 14.99% 6216 10578361 Asah1 0.2 1.2 9.3 4.33E-02 14.99% 6217 10484547 Olfr1016 -0.2 0.8 5.3 4.33E-02 14.99% 6218 10578768 0.2 1.1 6.9 4.33E-02 14.99% 6219 10428308 G930009F23Rik -0.2 0.9 4.4 4.33E-02 14.99% 6220 10371396 Mterfd3 0.2 1.1 5.6 4.34E-02 14.99% 6221 10387992 Nup88 0.2 1.1 9.6 4.34E-02 14.99%

Page 152 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6222 10547740 C1s -0.2 0.9 10.4 4.34E-02 15.00% 6223 10409986 4933434E20Rik 0.1 1.1 9.8 4.34E-02 15.00% 6224 10341104 0.4 1.3 5.2 4.34E-02 15.00% 6225 10379795 Synrg 0.2 1.1 7.9 4.34E-02 15.00% 6226 10552398 Lim2 -0.2 0.9 6.0 4.34E-02 15.00% 6227 10463173 Zdhhc16 0.2 1.1 7.8 4.34E-02 15.00% 6228 10425299 Tomm22 0.3 1.2 6.8 4.34E-02 15.00% 6229 10402721 Xrcc3 -0.2 0.9 7.3 4.34E-02 15.00% 6230 10432236 Rnd1 -0.3 0.8 7.2 4.35E-02 15.01% 6231 10560164 Obox6 -0.3 0.8 3.6 4.35E-02 15.01% 6232 10372831 Tbc1d30 -0.3 0.8 6.5 4.35E-02 15.01% 6233 10338248 -0.4 0.7 4.0 4.35E-02 15.01% 6234 10454944 Eif4ebp3 -0.5 0.7 9.6 4.35E-02 15.02% 6235 10557738 Ctf1 -0.1 0.9 7.1 4.35E-02 15.02% 6236 10584883 Fxyd6 -0.2 0.9 7.1 4.36E-02 15.02% 6237 10450161 H2-Ea-ps 0.3 1.3 6.0 4.36E-02 15.02% 6238 10429607 Top1mt 0.2 1.1 8.5 4.36E-02 15.03% 6239 10576482 Arv1 0.2 1.2 6.9 4.36E-02 15.03% 6240 10463308 Abcc2 -0.2 0.9 11.8 4.36E-02 15.03% 6241 10396740 Gphn -0.1 0.9 10.6 4.36E-02 15.03% 6242 10507870 0.6 1.5 10.3 4.36E-02 15.03% 6243 10413152 1700112E06Rik 0.2 1.1 6.3 4.36E-02 15.04% 6244 10427468 -0.3 0.8 7.6 4.36E-02 15.04% 6245 10466359 Olfr1475 0.3 1.2 3.0 4.37E-02 15.04% 6246 10507804 Trit1 -0.2 0.9 7.6 4.37E-02 15.04% 6247 10402648 Brp44l 0.1 1.1 11.8 4.37E-02 15.04% 6248 10554667 Tmc3 -0.2 0.9 5.2 4.37E-02 15.04% 6249 10390780 Krt222 -0.2 0.9 5.5 4.37E-02 15.04% 6250 10338794 0.6 1.5 5.9 4.37E-02 15.04% 6251 10409016 Nhlrc1 -0.2 0.9 8.7 4.37E-02 15.04% 6252 10463751 Pdcd11 0.2 1.1 7.4 4.37E-02 15.05% 6253 10530868 0.2 1.2 3.0 4.37E-02 15.05% 6254 10343668 -0.5 0.7 5.8 4.38E-02 15.05% 6255 10443021 Atp6v0e 0.2 1.1 9.5 4.38E-02 15.05% 6256 10344323 0.3 1.2 10.3 4.38E-02 15.05% 6257 10576610 Pard3 -0.1 0.9 8.8 4.38E-02 15.05% 6258 10342342 0.4 1.4 2.6 4.38E-02 15.05% 6259 10541751 0.1 1.1 3.9 4.38E-02 15.05% 6260 10393936 Cbr2 -0.2 0.9 5.6 4.38E-02 15.05% 6261 10429564 Ly6a 0.4 1.4 9.6 4.38E-02 15.05% 6262 10490894 E2f5 0.2 1.2 7.7 4.38E-02 15.05%

Page 153 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6263 10388109 Pitpnm3 -0.2 0.9 6.3 4.39E-02 15.06% 6264 10341897 0.4 1.3 7.0 4.39E-02 15.06% 6265 10470911 0.3 1.2 4.6 4.39E-02 15.06% 6266 10468309 Sh3pxd2a 0.3 1.2 8.3 4.39E-02 15.07% 6267 10341515 -0.4 0.7 6.1 4.39E-02 15.07% 6268 10556833 Abca14 -0.2 0.9 4.7 4.39E-02 15.07% 6269 10423733 -0.1 0.9 6.2 4.39E-02 15.07% 6270 10357476 -0.1 0.9 2.5 4.39E-02 15.07% 6271 10464811 -0.2 0.8 6.8 4.40E-02 15.07% 6272 10454735 Fam53c 0.1 1.1 7.4 4.40E-02 15.07% 6273 10565499 -0.2 0.9 5.4 4.40E-02 15.07% 6274 10511375 Cyp7a1 0.4 1.3 12.3 4.40E-02 15.08% 6275 10429506 Lypd2 -0.2 0.9 6.7 4.40E-02 15.08% 6276 10373702 Pisd-ps1 -0.2 0.9 7.9 4.41E-02 15.10% 6277 10343469 0.3 1.2 3.0 4.41E-02 15.10% 6278 10485013 1110051M20Rik -0.2 0.9 6.4 4.41E-02 15.11% 6279 10460704 -0.2 0.9 5.2 4.41E-02 15.11% 6280 10526215 Rps28 0.1 1.1 10.3 4.41E-02 15.11% 6281 10587546 Rpl7a 0.1 1.1 11.0 4.41E-02 15.11% 6282 10603547 0.2 1.1 6.5 4.41E-02 15.11% 6283 10450622 Atat1 -0.2 0.8 7.6 4.41E-02 15.11% 6284 10576901 Slc10a2 0.5 1.4 7.9 4.42E-02 15.11% 6285 10453573 Olfr63 -0.2 0.9 5.5 4.42E-02 15.11% 6286 10490826 Zbtb10 0.2 1.1 6.6 4.42E-02 15.11% 6287 10338295 -0.2 0.9 10.2 4.42E-02 15.12% 6288 10342946 0.3 1.2 2.5 4.42E-02 15.12% 6289 10553833 Ndn -0.2 0.9 6.5 4.42E-02 15.12% 6290 10476512 Snap25 -0.2 0.9 5.4 4.42E-02 15.12% 6291 10508436 Sync -0.3 0.8 6.3 4.42E-02 15.12% 6292 10580231 -0.3 0.8 7.5 4.42E-02 15.12% 6293 10508709 -0.2 0.9 5.7 4.43E-02 15.12% 6294 10454856 Psd2 -0.2 0.9 5.7 4.43E-02 15.12% 6295 10413932 E130203B14Rik -0.2 0.9 7.2 4.43E-02 15.12% 6296 10344750 Sgk3 0.2 1.1 9.1 4.43E-02 15.12% 6297 10453102 Srsf7 0.2 1.2 8.6 4.43E-02 15.12% 6298 10463557 Gbf1 0.3 1.2 9.7 4.43E-02 15.12% 6299 10470314 0.4 1.3 5.9 4.43E-02 15.14% 6300 10477169 Id1 0.4 1.4 8.1 4.44E-02 15.14% 6301 10558612 Olfr523 -0.2 0.8 5.7 4.44E-02 15.15% 6302 10587023 Rab27a -0.2 0.9 6.7 4.44E-02 15.15% 6303 10344462 0.4 1.3 2.7 4.44E-02 15.15%

Page 154 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6304 10594969 Unc13c -0.2 0.9 5.7 4.44E-02 15.15% 6305 10599853 Ldoc1 -0.2 0.9 4.8 4.44E-02 15.15% 6306 10400803 0.4 1.3 5.8 4.44E-02 15.16% 6307 10346668 Fam117b -0.2 0.9 7.8 4.45E-02 15.17% 6308 10444778 0.7 1.6 6.9 4.45E-02 15.18% 6309 10507236 -0.2 0.9 6.1 4.45E-02 15.18% 6310 10522976 Rufy3 -0.2 0.9 8.2 4.45E-02 15.18% 6311 10584479 Olfr933 -0.2 0.9 4.6 4.45E-02 15.18% 6312 10538459 Aqp1 -0.2 0.9 9.6 4.46E-02 15.18% 6313 10343923 0.7 1.6 3.5 4.46E-02 15.18% 6314 10490244 -0.2 0.9 5.9 4.46E-02 15.19% 6315 10490271 -0.2 0.9 5.9 4.46E-02 15.19% 6316 10566846 Dennd5a 0.1 1.1 8.8 4.46E-02 15.19% 6317 10595126 Fbxo9 -0.2 0.9 9.0 4.46E-02 15.19% 6318 10422057 Rpl7a 0.1 1.1 11.0 4.46E-02 15.19% 6319 10448226 Vmn2r111 0.2 1.2 3.1 4.46E-02 15.19% 6320 10448700 Gfer 0.2 1.1 8.1 4.46E-02 15.20% 6321 10527562 Gsx1 -0.3 0.8 6.4 4.47E-02 15.21% 6322 10452082 Znrf4 -0.2 0.9 6.4 4.47E-02 15.21% 6323 10342641 -0.3 0.8 9.6 4.47E-02 15.21% 6324 10575598 Znrf1 -0.1 0.9 8.2 4.47E-02 15.21% 6325 10342089 -0.5 0.7 8.5 4.47E-02 15.21% 6326 10601768 0.3 1.3 6.9 4.47E-02 15.21% 6327 10519675 Gm8912 0.2 1.2 7.9 4.48E-02 15.22% 6328 10386370 Arf1 0.1 1.1 11.9 4.48E-02 15.22% 6329 10373692 Vmn2r86 -0.5 0.7 4.7 4.48E-02 15.22% 6330 10361926 Map3k5 -0.3 0.8 8.8 4.48E-02 15.23% 6331 10602020 Tbc1d8b 0.3 1.2 7.8 4.48E-02 15.24% 6332 10406111 Slc12a7 -0.2 0.9 9.0 4.49E-02 15.24% 6333 10480649 2310002J15Rik -0.2 0.9 6.7 4.49E-02 15.24% 6334 10342282 -0.1 0.9 11.5 4.49E-02 15.24% 6335 10449315 2900010M23Rik 0.2 1.1 10.1 4.49E-02 15.24% 6336 10429424 -0.2 0.9 7.0 4.49E-02 15.24% 6337 10343508 0.8 1.7 4.6 4.49E-02 15.24% 6338 10463123 Dntt 0.3 1.2 5.5 4.49E-02 15.24% 6339 10477297 Kif3b 0.1 1.1 7.4 4.49E-02 15.25% 6340 10589196 Uqcrc1 -0.2 0.9 10.8 4.49E-02 15.25% 6341 10338990 0.5 1.4 5.2 4.50E-02 15.26% 6342 10420225 Cma1 -0.2 0.9 4.9 4.50E-02 15.26% 6343 10386236 Hist3h2bb-ps 0.1 1.1 5.7 4.50E-02 15.26% 6344 10478774 Arfgef2 0.2 1.1 9.3 4.50E-02 15.27%

Page 155 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6345 10476395 Bmp2 -0.3 0.8 8.2 4.50E-02 15.27% 6346 10340503 0.4 1.3 5.9 4.51E-02 15.28% 6347 10546685 Eif4e3 0.2 1.1 7.2 4.51E-02 15.28% 6348 10342292 0.4 1.3 4.8 4.51E-02 15.28% 6349 10340432 0.4 1.3 8.4 4.51E-02 15.28% 6350 10534102 Gusb 0.2 1.1 8.2 4.51E-02 15.28% 6351 10341229 -0.4 0.7 5.0 4.51E-02 15.28% 6352 10570951 Nkx6-3 -0.3 0.8 6.3 4.51E-02 15.28% 6353 10567173 Pik3c2a 0.2 1.2 9.2 4.51E-02 15.28% 6354 10406403 0.2 1.1 3.7 4.51E-02 15.28% 6355 10376832 Adora2b -0.2 0.9 5.5 4.52E-02 15.28% 6356 10347774 Mrpl44 0.1 1.1 6.7 4.52E-02 15.28% 6357 10339877 -0.2 0.8 8.5 4.52E-02 15.28% 6358 10420736 Neil2 -0.2 0.9 5.1 4.52E-02 15.28% 6359 10341490 0.3 1.2 6.7 4.52E-02 15.28% 6360 10572525 -0.2 0.9 5.7 4.52E-02 15.28% 6361 10378427 Olfr401 -0.3 0.8 6.6 4.52E-02 15.28% 6362 10414734 -0.3 0.8 2.6 4.52E-02 15.28% 6363 10373101 Pip4k2c 0.1 1.1 8.6 4.52E-02 15.28% 6364 10441396 Ppia -0.1 0.9 11.7 4.52E-02 15.28% 6365 10445746 Trem1 0.2 1.1 4.9 4.52E-02 15.28% 6366 10447437 Klraq1 0.2 1.1 8.4 4.52E-02 15.28% 6367 10522366 -0.2 0.8 4.4 4.52E-02 15.28% 6368 10460273 Tbx10 -0.2 0.9 6.3 4.52E-02 15.28% 6369 10428579 Ext1 0.2 1.1 9.0 4.53E-02 15.28% 6370 10375137 Kcnmb1 -0.2 0.9 5.2 4.53E-02 15.28% 6371 10553115 Lmtk3 -0.2 0.8 7.5 4.53E-02 15.28% 6372 10339851 0.5 1.4 5.7 4.53E-02 15.29% 6373 10399555 Kcnf1 -0.2 0.9 5.4 4.53E-02 15.29% 6374 10344073 -0.3 0.8 7.4 4.53E-02 15.29% 6375 10523293 -0.2 0.8 4.3 4.53E-02 15.29% 6376 10490097 Cbln4 -0.2 0.9 5.8 4.53E-02 15.29% 6377 10593832 0.2 1.2 5.2 4.53E-02 15.29% 6378 10519046 5930403L14Rik -0.2 0.9 7.6 4.53E-02 15.29% 6379 10339699 -0.4 0.8 4.4 4.53E-02 15.29% 6380 10477406 Rya3 -0.2 0.9 5.9 4.54E-02 15.29% 6381 10340382 0.7 1.6 5.7 4.54E-02 15.30% 6382 10465619 Flrt1 -0.2 0.9 6.6 4.54E-02 15.30% 6383 10339693 -0.4 0.7 6.3 4.54E-02 15.30% 6384 10547701 Pex5 -0.2 0.9 8.7 4.54E-02 15.30% 6385 10358613 Hmcn1 -0.2 0.9 5.4 4.54E-02 15.30%

Page 156 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6386 10339205 0.3 1.2 9.7 4.54E-02 15.31% 6387 10460616 Cfl1 0.1 1.1 11.0 4.54E-02 15.31% 6388 10505261 -0.2 0.8 11.0 4.55E-02 15.31% 6389 10483809 Nfe2l2 0.2 1.1 11.0 4.55E-02 15.31% 6390 10432527 Lass5 0.2 1.2 7.5 4.55E-02 15.31% 6391 10339057 -0.2 0.8 8.0 4.55E-02 15.31% 6392 10443195 Hmga1 -0.3 0.8 10.4 4.56E-02 15.33% 6393 10414775 -0.2 0.9 6.8 4.56E-02 15.33% 6394 10414882 -0.2 0.9 6.8 4.56E-02 15.33% 6395 10489629 Cdh22 -0.1 0.9 6.2 4.56E-02 15.33% 6396 10570379 Grk1 -0.2 0.9 5.0 4.56E-02 15.33% 6397 10606261 Rpl12 0.2 1.1 12.3 4.56E-02 15.33% 6398 10514070 2310067E19Rik -0.3 0.8 7.1 4.56E-02 15.33% 6399 10363786 Ank3 -0.2 0.9 7.3 4.56E-02 15.35% 6400 10527148 Slc29a4 -0.2 0.9 5.7 4.57E-02 15.35% 6401 10398082 -0.2 0.9 5.5 4.57E-02 15.35% 6402 10582899 0.7 1.6 8.2 4.57E-02 15.35% 6403 10414751 -0.2 0.9 7.1 4.57E-02 15.35% 6404 10498595 Snrpd2 0.2 1.1 8.5 4.57E-02 15.35% 6405 10473281 Itgav 0.1 1.1 9.1 4.57E-02 15.36% 6406 10562812 Spib -0.2 0.9 5.8 4.58E-02 15.36% 6407 10559782 Olfr5 -0.2 0.9 5.8 4.58E-02 15.36% 6408 10406250 Rpl37a 0.2 1.1 10.9 4.58E-02 15.36% 6409 10489239 9430008C03Rik 0.3 1.2 8.1 4.58E-02 15.36% 6410 10551293 Cyp2f2 -0.1 0.9 13.3 4.58E-02 15.36% 6411 10341469 0.4 1.4 2.8 4.58E-02 15.36% 6412 10457205 Crem 0.3 1.2 7.6 4.58E-02 15.36% 6413 10470158 Lcn6 -0.2 0.9 5.1 4.58E-02 15.36% 6414 10341681 -0.2 0.9 11.6 4.58E-02 15.37% 6415 10497381 Cyp7b1 0.4 1.3 11.2 4.58E-02 15.37% 6416 10339828 -0.7 0.6 4.0 4.58E-02 15.37% 6417 10492516 Iqcj -0.2 0.9 4.8 4.59E-02 15.38% 6418 10342163 -0.2 0.8 8.7 4.59E-02 15.39% 6419 10339812 0.3 1.2 10.2 4.60E-02 15.40% 6420 10338979 -0.3 0.8 8.7 4.60E-02 15.41% 6421 10520633 Tcf23 -0.2 0.9 6.5 4.60E-02 15.42% 6422 10474518 -0.3 0.8 8.0 4.60E-02 15.42% 6423 10548359 Clec12b -0.2 0.9 5.4 4.60E-02 15.42% 6424 10495340 Taf13 0.2 1.1 6.8 4.60E-02 15.42% 6425 10393844 Thoc4 0.2 1.1 10.3 4.61E-02 15.42% 6426 10557355 D430042O09Rik 0.3 1.2 7.5 4.61E-02 15.42%

Page 157 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6427 10520268 -0.2 0.9 6.4 4.61E-02 15.42% 6428 10342353 0.4 1.3 5.0 4.61E-02 15.42% 6429 10548116 0.3 1.2 9.1 4.61E-02 15.42% 6430 10478754 Arfgef2 0.2 1.1 9.7 4.61E-02 15.42% 6431 10540991 Rho -0.2 0.9 5.9 4.61E-02 15.42% 6432 10564005 0.2 1.2 2.8 4.61E-02 15.42% 6433 10369927 -0.2 0.9 6.3 4.61E-02 15.43% 6434 10399387 Msgn1 -0.2 0.9 6.9 4.62E-02 15.43% 6435 10357239 Tmem37 0.3 1.2 9.4 4.62E-02 15.43% 6436 10495964 Neurog2 -0.2 0.9 5.7 4.62E-02 15.43% 6437 10351563 B4galt3 0.2 1.1 7.1 4.62E-02 15.43% 6438 10527936 Fzd1 0.1 1.1 8.1 4.62E-02 15.43% 6439 10396193 Psma3 0.2 1.2 11.0 4.62E-02 15.43% 6440 10517312 Tmem57 -0.2 0.9 9.1 4.62E-02 15.44% 6441 10338605 -0.3 0.8 8.5 4.62E-02 15.44% 6442 10437712 Zc3h7a 0.3 1.2 8.7 4.62E-02 15.44% 6443 10482467 Orc4 0.2 1.2 8.0 4.63E-02 15.45% 6444 10519211 Tas1r3 -0.2 0.9 6.5 4.63E-02 15.45% 6445 10514930 -0.2 0.9 6.0 4.63E-02 15.45% 6446 10410124 Ctsl -0.3 0.8 11.6 4.63E-02 15.45% 6447 10339257 -0.4 0.8 5.4 4.63E-02 15.45% 6448 10439206 0.2 1.2 3.9 4.63E-02 15.45% 6449 10593245 Htr3b -0.2 0.9 5.7 4.63E-02 15.46% 6450 10364321 Krtap12-1 -0.2 0.9 5.9 4.63E-02 15.46% 6451 10339431 -0.4 0.7 3.6 4.64E-02 15.47% 6452 10387557 0.3 1.2 8.1 4.64E-02 15.47% 6453 10346168 Stat4 0.2 1.2 5.1 4.64E-02 15.47% 6454 10339344 0.4 1.3 7.3 4.64E-02 15.47% 6455 10487267 Polr2l 0.2 1.1 10.6 4.64E-02 15.48% 6456 10525677 Hip1r 0.1 1.1 7.6 4.65E-02 15.48% 6457 10417415 Gm1973 0.1 1.1 3.3 4.65E-02 15.49% 6458 10568215 Gm4532 -0.3 0.8 7.4 4.65E-02 15.49% 6459 10340956 0.3 1.2 9.1 4.65E-02 15.49% 6460 10343862 -0.2 0.8 7.7 4.65E-02 15.49% 6461 10452440 -0.2 0.9 6.4 4.65E-02 15.49% 6462 10563913 0.3 1.2 3.0 4.65E-02 15.49% 6463 10563917 0.3 1.2 3.0 4.65E-02 15.49% 6464 10563923 0.3 1.2 3.0 4.65E-02 15.49% 6465 10573319 Podnl1 -0.2 0.9 5.8 4.66E-02 15.49% 6466 10557069 Mettl9 0.2 1.1 9.5 4.66E-02 15.49% 6467 10544342 Gm10334 -0.2 0.9 5.4 4.66E-02 15.49%

Page 158 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6468 10571958 Sh3rf1 -0.2 0.9 7.5 4.66E-02 15.49% 6469 10452538 1110012J17Rik -0.1 0.9 6.4 4.66E-02 15.49% 6470 10531664 -0.2 0.9 5.9 4.66E-02 15.49% 6471 10491354 Zfp639 0.2 1.2 7.2 4.66E-02 15.49% 6472 10434283 -0.3 0.8 10.2 4.66E-02 15.50% 6473 10488195 Rrbp1 0.3 1.2 10.1 4.66E-02 15.50% 6474 10601978 -0.2 0.9 5.8 4.67E-02 15.50% 6475 10340087 -0.4 0.7 6.6 4.67E-02 15.51% 6476 10473224 Dusp19 0.2 1.1 8.5 4.67E-02 15.51% 6477 10348570 Espnl -0.2 0.9 6.8 4.67E-02 15.51% 6478 10351179 2810422O20Rik 0.3 1.2 6.6 4.67E-02 15.52% 6479 10445891 -0.2 0.9 6.6 4.68E-02 15.52% 6480 10561561 Ryr1 -0.3 0.8 5.9 4.68E-02 15.52% 6481 10533549 Anapc5 0.2 1.1 9.8 4.68E-02 15.52% 6482 10459770 -0.2 0.9 8.8 4.68E-02 15.52% 6483 10595911 Foxl2os -0.2 0.9 6.9 4.68E-02 15.52% 6484 10458997 Prrc1 -0.2 0.9 6.6 4.68E-02 15.52% 6485 10484699 Olfr1155 0.2 1.1 4.4 4.68E-02 15.52% 6486 10416037 Pbk 0.5 1.4 5.5 4.68E-02 15.52% 6487 10343433 -0.3 0.8 6.6 4.68E-02 15.52% 6488 10603651 1810030O07Rik 0.2 1.1 7.6 4.69E-02 15.54% 6489 10608639 D13Ertd608e -0.2 0.9 5.0 4.69E-02 15.54% 6490 10341251 -0.3 0.8 7.0 4.69E-02 15.54% 6491 10375886 D930048N14Rik -0.2 0.9 7.7 4.69E-02 15.54% 6492 10340912 0.5 1.4 3.8 4.69E-02 15.54% 6493 10440685 Krtap16-5 -0.2 0.9 4.3 4.69E-02 15.54% 6494 10439092 1700021K19Rik 0.1 1.1 7.7 4.69E-02 15.54% 6495 10590445 Snrk -0.2 0.9 10.4 4.69E-02 15.54% 6496 10581914 Chst5 -0.2 0.9 6.1 4.70E-02 15.56% 6497 10581573 -0.2 0.9 6.5 4.70E-02 15.56% 6498 10420666 Mir16-1 -0.3 0.8 6.3 4.70E-02 15.56% 6499 10521731 Ncapg 0.6 1.6 5.7 4.70E-02 15.56% 6500 10484894 Ptprj -0.2 0.9 10.5 4.70E-02 15.56% 6501 10508907 Lin28a -0.2 0.9 4.0 4.70E-02 15.56% 6502 10415392 Ltb4r1 -0.1 0.9 5.7 4.70E-02 15.56% 6503 10608209 Srsy 0.1 1.1 3.3 4.71E-02 15.57% 6504 10494761 Vtcn1 0.3 1.2 6.7 4.71E-02 15.57% 6505 10485151 Mapk8ip1 -0.1 0.9 6.7 4.71E-02 15.57% 6506 10493449 Thbs3 -0.2 0.9 5.9 4.71E-02 15.58% 6507 10562096 Tmem147 0.2 1.2 10.1 4.71E-02 15.58% 6508 10340595 0.3 1.2 2.4 4.71E-02 15.58%

Page 159 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6509 10426782 Accn2 -0.2 0.9 5.9 4.72E-02 15.59% 6510 10413398 Il17rd -0.2 0.9 6.0 4.72E-02 15.59% 6511 10415957 -0.3 0.8 5.1 4.72E-02 15.59% 6512 10338481 -0.5 0.7 5.7 4.72E-02 15.60% 6513 10387855 Alox15 -0.2 0.9 5.9 4.73E-02 15.61% 6514 10531928 -0.3 0.8 7.6 4.73E-02 15.61% 6515 10532025 Rps15a 0.2 1.1 8.9 4.73E-02 15.62% 6516 10396143 Gm3086 -0.2 0.9 6.4 4.73E-02 15.62% 6517 10378547 Mir132 -0.3 0.8 5.3 4.73E-02 15.62% 6518 10355162 Plekhm3 0.2 1.1 6.4 4.73E-02 15.62% 6519 10512621 Olfr70 -0.2 0.9 5.6 4.73E-02 15.62% 6520 10353849 4632411B12Rik -0.2 0.9 8.2 4.74E-02 15.63% 6521 10590004 Golga4 0.3 1.2 7.9 4.74E-02 15.63% 6522 10487380 -0.2 0.9 6.6 4.74E-02 15.63% 6523 10556611 0.2 1.2 7.0 4.74E-02 15.63% 6524 10344813 Cspp1 0.3 1.2 8.0 4.74E-02 15.63% 6525 10450206 Rnf5 -0.2 0.9 9.5 4.74E-02 15.63% 6526 10388269 -0.3 0.8 4.2 4.74E-02 15.63% 6527 10584458 Olfr920 0.2 1.2 4.6 4.74E-02 15.63% 6528 10454842 Ube2d2 0.1 1.1 10.3 4.74E-02 15.63% 6529 10438621 Tra2b 0.2 1.1 8.8 4.74E-02 15.63% 6530 10341774 -0.2 0.9 7.5 4.74E-02 15.63% 6531 10397907 Cox8c -0.2 0.9 6.2 4.75E-02 15.63% 6532 10403834 Sfrp4 -0.3 0.8 4.5 4.75E-02 15.63% 6533 10468593 Nrap -0.3 0.8 6.2 4.75E-02 15.63% 6534 10455695 Srfbp1 0.3 1.2 7.5 4.75E-02 15.64% 6535 10544891 Nod1 0.2 1.1 7.8 4.75E-02 15.64% 6536 10600547 Tbl1x -0.2 0.9 9.7 4.75E-02 15.64% 6537 10340610 -0.3 0.8 6.1 4.75E-02 15.64% 6538 10478554 Gm14316 -0.2 0.9 5.4 4.75E-02 15.64% 6539 10403248 Speer6-ps1 -0.3 0.8 3.4 4.76E-02 15.64% 6540 10427718 Brix1 0.3 1.2 7.9 4.76E-02 15.64% 6541 10514815 Tmem61 -0.2 0.9 6.5 4.76E-02 15.64% 6542 10364550 Kiss1r -0.2 0.9 6.1 4.76E-02 15.64% 6543 10340600 0.1 1.1 11.8 4.76E-02 15.64% 6544 10574939 Pskh1 -0.2 0.9 9.3 4.76E-02 15.64% 6545 10344166 -0.5 0.7 6.8 4.76E-02 15.64% 6546 10342367 0.7 1.6 5.2 4.76E-02 15.65% 6547 10479615 Gm14462 -0.2 0.9 6.6 4.76E-02 15.65% 6548 10542036 -0.2 0.9 4.8 4.76E-02 15.65% 6549 10339755 -0.2 0.8 8.0 4.76E-02 15.65%

Page 160 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6550 10340278 -0.4 0.8 7.1 4.77E-02 15.65% 6551 10583647 Dnm2 0.1 1.1 9.6 4.77E-02 15.65% 6552 10432404 Tuba1a 0.3 1.2 7.4 4.77E-02 15.66% 6553 10382482 Otop2 -0.2 0.9 6.4 4.77E-02 15.66% 6554 10607113 Rgs3 0.2 1.1 7.2 4.77E-02 15.66% 6555 10411432 Utp15 0.2 1.1 7.3 4.77E-02 15.66% 6556 10341993 0.4 1.3 6.0 4.77E-02 15.66% 6557 10462228 Dmrt3 -0.3 0.8 6.9 4.77E-02 15.66% 6558 10338700 -0.4 0.8 7.0 4.78E-02 15.67% 6559 10562603 0.2 1.1 2.5 4.78E-02 15.67% 6560 10595892 -0.2 0.9 6.0 4.78E-02 15.67% 6561 10552000 2200002J24Rik -0.2 0.9 5.7 4.79E-02 15.70% 6562 10492049 Fam48a 0.2 1.1 8.6 4.79E-02 15.70% 6563 10538082 Atp6v0e2 -0.2 0.9 7.0 4.79E-02 15.71% 6564 10343021 0.4 1.3 7.3 4.80E-02 15.72% 6565 10505982 Fggy -0.2 0.9 10.3 4.80E-02 15.72% 6566 10342784 0.5 1.4 4.8 4.80E-02 15.72% 6567 10343752 -0.4 0.8 5.3 4.80E-02 15.72% 6568 10524606 4930519G04Rik -0.1 0.9 5.2 4.80E-02 15.73% 6569 10399579 -0.2 0.9 7.1 4.80E-02 15.73% 6570 10343627 0.4 1.3 3.5 4.81E-02 15.73% 6571 10594754 Foxb1 -0.2 0.9 5.9 4.81E-02 15.74% 6572 10478022 Rprd1b 0.1 1.1 8.4 4.81E-02 15.75% 6573 10338066 0.2 1.2 5.1 4.82E-02 15.76% 6574 10576559 4933403G14Rik -0.2 0.9 6.1 4.82E-02 15.76% 6575 10399908 Prkar2b -0.2 0.9 6.1 4.82E-02 15.76% 6576 10568586 Fam53b 0.2 1.1 7.3 4.82E-02 15.76% 6577 10353783 Ccdc115 0.2 1.2 6.9 4.82E-02 15.76% 6578 10539822 Copg 0.2 1.2 9.4 4.82E-02 15.76% 6579 10558769 Ifitm1 0.2 1.2 8.8 4.82E-02 15.76% 6580 10451665 Apobec2 -0.3 0.8 5.9 4.82E-02 15.77% 6581 10550167 -0.2 0.9 6.2 4.83E-02 15.77% 6582 10541061 Olfr211 -0.2 0.8 5.1 4.83E-02 15.77% 6583 10562687 Iglon5 -0.2 0.9 6.5 4.83E-02 15.77% 6584 10396730 0.2 1.2 5.2 4.83E-02 15.77% 6585 10448506 Ccnf 0.5 1.4 6.7 4.83E-02 15.78% 6586 10378065 4930563E22Rik -0.2 0.9 6.0 4.83E-02 15.78% 6587 10403291 Akr1c14 -0.2 0.8 11.7 4.83E-02 15.78% 6588 10582592 Acta1 -0.9 0.5 7.1 4.83E-02 15.78% 6589 10591110 Fat3 -0.2 0.9 6.5 4.83E-02 15.78% 6590 10423287 Cdh18 -0.2 0.9 5.2 4.83E-02 15.78%

Page 161 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6591 10462752 Btaf1 0.2 1.2 8.5 4.84E-02 15.78% 6592 10550487 Mill1 -0.2 0.9 5.9 4.84E-02 15.78% 6593 10551435 9530053A07Rik -0.2 0.9 6.1 4.84E-02 15.78% 6594 10457669 Dsc3 -0.1 0.9 4.5 4.84E-02 15.78% 6595 10520506 Kcnk3 -0.2 0.9 7.0 4.84E-02 15.78% 6596 10568968 Syce1 -0.2 0.9 4.7 4.84E-02 15.78% 6597 10489179 Ghrh -0.2 0.9 5.4 4.84E-02 15.78% 6598 10418210 D14Ertd449e -0.2 0.9 10.0 4.84E-02 15.78% 6599 10538142 Gimap5 0.3 1.2 5.1 4.84E-02 15.78% 6600 10515154 Rpl3 0.1 1.1 10.9 4.84E-02 15.78% 6601 10602644 Kdm5c 0.2 1.1 9.1 4.84E-02 15.78% 6602 10384454 0.3 1.3 4.6 4.84E-02 15.78% 6603 10341900 0.3 1.2 6.1 4.85E-02 15.79% 6604 10429199 Mir30d -0.2 0.9 6.8 4.85E-02 15.79% 6605 10342727 0.7 1.6 4.5 4.85E-02 15.79% 6606 10373192 Inhbe 0.5 1.4 9.2 4.85E-02 15.79% 6607 10538466 Ghrhr -0.2 0.9 6.9 4.85E-02 15.79% 6608 10538684 Tigd2 0.2 1.1 7.9 4.85E-02 15.79% 6609 10417933 Myoz1 -0.4 0.8 5.6 4.86E-02 15.81% 6610 10430669 Rpl3 0.1 1.1 11.5 4.86E-02 15.81% 6611 10398378 0.2 1.1 3.1 4.86E-02 15.81% 6612 10452384 Rpl7a 0.1 1.1 11.2 4.86E-02 15.81% 6613 10539710 Tia1 0.3 1.2 6.9 4.86E-02 15.81% 6614 10576844 BC068157 -0.2 0.9 6.0 4.86E-02 15.81% 6615 10486154 A430105I19Rik -0.2 0.9 7.0 4.86E-02 15.82% 6616 10546227 -0.2 0.9 5.4 4.87E-02 15.82% 6617 10505705 Sh3gl2 -0.1 0.9 6.3 4.87E-02 15.82% 6618 10552406 Nkg7 0.2 1.2 6.3 4.87E-02 15.83% 6619 10361642 Lrp11 -0.2 0.9 6.5 4.87E-02 15.83% 6620 10344276 -0.4 0.8 6.8 4.87E-02 15.83% 6621 10547022 Timp4 -0.2 0.9 5.2 4.87E-02 15.83% 6622 10465912 Fen1 0.4 1.3 6.5 4.87E-02 15.83% 6623 10545877 Nat8 -0.3 0.8 5.8 4.87E-02 15.83% 6624 10468344 Col17a1 -0.2 0.9 6.4 4.88E-02 15.83% 6625 10338309 0.3 1.3 2.8 4.88E-02 15.83% 6626 10456887 Loxhd1 -0.2 0.9 6.3 4.88E-02 15.84% 6627 10453575 Cul2 0.3 1.2 9.5 4.88E-02 15.84% 6628 10587488 Mei4 -0.2 0.9 5.2 4.88E-02 15.84% 6629 10569485 Tnfrsf26 0.1 1.1 5.8 4.88E-02 15.84% 6630 10380620 Mir196a-1 -0.2 0.9 4.5 4.88E-02 15.85% 6631 10473024 Agps 0.2 1.2 7.2 4.89E-02 15.86%

Page 162 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6632 10465861 Incenp 0.2 1.1 6.0 4.89E-02 15.86% 6633 10479402 1600027N09Rik 0.2 1.1 6.7 4.89E-02 15.86% 6634 10555293 Lipt2 0.2 1.1 8.6 4.89E-02 15.86% 6635 10524079 0.3 1.3 8.3 4.89E-02 15.86% 6636 10408134 Vmn1r193 -0.2 0.9 5.2 4.89E-02 15.86% 6637 10516221 -0.2 0.9 6.3 4.89E-02 15.86% 6638 10460385 Clcf1 -0.2 0.9 6.3 4.90E-02 15.86% 6639 10599088 4930408F14Rik -0.2 0.9 5.2 4.90E-02 15.87% 6640 10489043 2900097C17Rik -0.2 0.9 9.2 4.90E-02 15.87% 6641 10357886 0.2 1.1 2.5 4.90E-02 15.87% 6642 10449339 -0.2 0.9 5.5 4.90E-02 15.87% 6643 10483439 Lrp2 -0.3 0.8 5.9 4.90E-02 15.88% 6644 10497451 Cpa3 -0.3 0.8 4.3 4.90E-02 15.88% 6645 10423836 Cthrc1 -0.2 0.9 5.7 4.91E-02 15.88% 6646 10490802 Fam164a 0.3 1.2 6.8 4.91E-02 15.89% 6647 10549536 Amn1 0.3 1.2 7.7 4.91E-02 15.89% 6648 10382069 Psmc5 0.2 1.2 8.1 4.91E-02 15.90% 6649 10340864 -0.4 0.7 7.4 4.92E-02 15.91% 6650 10410252 0.2 1.1 4.0 4.92E-02 15.92% 6651 10340246 0.3 1.3 2.5 4.92E-02 15.92% 6652 10393761 2310003H01Rik -0.2 0.9 7.2 4.93E-02 15.92% 6653 10524082 0.4 1.3 7.8 4.93E-02 15.92% 6654 10598763 Gm5382 -0.2 0.9 5.9 4.93E-02 15.92% 6655 10441660 T2 -0.2 0.9 5.7 4.93E-02 15.92% 6656 10403495 Zp4-ps -0.2 0.9 4.4 4.93E-02 15.92% 6657 10342734 0.7 1.6 3.0 4.93E-02 15.92% 6658 10512065 0.4 1.3 4.6 4.93E-02 15.92% 6659 10496862 -0.2 0.9 6.9 4.93E-02 15.92% 6660 10496130 Tbck 0.1 1.1 9.0 4.93E-02 15.92% 6661 10373986 Ap1b1 0.1 1.1 9.2 4.93E-02 15.92% 6662 10514708 Insl5 -0.2 0.9 5.3 4.93E-02 15.93% 6663 10439936 Nfkbiz 0.3 1.2 7.5 4.93E-02 15.93% 6664 10607388 Rpl7a 0.1 1.1 10.1 4.94E-02 15.93% 6665 10526302 Tbl2 0.2 1.1 8.4 4.94E-02 15.94% 6666 10453373 Prepl 0.1 1.1 9.0 4.94E-02 15.94% 6667 10551644 Capn12 -0.2 0.9 5.9 4.94E-02 15.94% 6668 10488147 Flrt3 -0.1 0.9 4.7 4.94E-02 15.94% 6669 10504775 Col15a1 0.2 1.2 7.4 4.95E-02 15.96% 6670 10390923 Krtap4-2 -0.1 0.9 5.2 4.95E-02 15.96% 6671 10509985 Fam131c -0.2 0.9 6.6 4.95E-02 15.96% 6672 10569437 Phlda2 0.3 1.2 6.7 4.95E-02 15.96%

Page 163 of 164 Rank Affymetrix Gene Symbol Log2 Fold Fold Log2 Unadjusted P- FDR Probe ID Change Change Avg FI Value

6673 10390618 Neurod2 -0.2 0.9 6.7 4.95E-02 15.96% 6674 10504817 Tgfbr1 0.2 1.1 8.4 4.95E-02 15.96% 6675 10448016 Tcte3 0.1 1.1 6.1 4.95E-02 15.96% 6676 10555681 Stim1 0.1 1.1 8.3 4.96E-02 15.98% 6677 10506298 Leprot 0.2 1.1 7.4 4.96E-02 15.98% 6678 10503303 1110037F02Rik 0.2 1.1 7.3 4.96E-02 15.98% 6679 10428169 Rpl7a 0.1 1.1 11.3 4.96E-02 15.98% 6680 10507555 -0.2 0.9 6.1 4.96E-02 15.98% 6681 10543591 Opn1sw -0.2 0.9 5.4 4.96E-02 15.98% 6682 10413874 Ogdhl -0.2 0.9 5.6 4.97E-02 16.00% 6683 10463168 Pgam1 -0.1 0.9 10.0 4.97E-02 16.00% 6684 10561302 Pgam1 -0.1 0.9 10.0 4.97E-02 16.00% 6685 10466886 -0.2 0.9 5.3 4.97E-02 16.00% 6686 10422240 Slitrk1 -0.2 0.9 5.4 4.97E-02 16.00% 6687 10472058 Rif1 0.2 1.2 7.7 4.97E-02 16.00% 6688 10421444 Npm2 -0.2 0.8 4.4 4.98E-02 16.00% 6689 10376019 0.4 1.3 4.3 4.98E-02 16.00% 6690 10454836 1700066B19Rik -0.2 0.9 5.7 4.98E-02 16.01% 6691 10498155 Rps14 -0.2 0.9 10.4 4.98E-02 16.01% 6692 10445753 Trem3 0.2 1.2 5.2 4.98E-02 16.01% 6693 10340393 0.4 1.3 7.2 4.98E-02 16.02% 6694 10503363 Rbm12b -0.2 0.9 7.9 4.99E-02 16.02% 6695 10584252 Gm9513 -0.3 0.8 7.9 4.99E-02 16.02% 6696 10389127 Unc45b -0.2 0.9 6.7 4.99E-02 16.02% 6697 10590433 1700048O20Rik 0.4 1.3 6.7 4.99E-02 16.03% 6698 10418729 Colq -0.2 0.9 6.5 4.99E-02 16.03% 6699 10567452 -0.2 0.9 3.1 4.99E-02 16.03% 6700 10356880 St8sia4 0.2 1.1 5.4 4.99E-02 16.03% Genes were ranked by unadjusted p-value (lowest to highest). Genes with an unadjusted p- value less than 0.05 were included. Shown are fold-changes compared to gd 0. Fold-change is defined as the ratio of fluorescent intensity of the gene on a gestation day to that on gd 0. Avg, Average; FI, fluorescence intensity; FDR, False discovery rate based on Storey q-value.

Page 164 of 164