New Horizons in Drug Discovery & Development-2 16TH November, 2015

ORGANIZED BY Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard

in collaboration with Indian Pharmaceutical Association ( Branch)

Monday, 16th November 2015

Venue: Auditorium, Faculty of Pharmacy, Jamia Hamdard, -62

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

ORGANIZING COMMITTEE

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

The history of Jamia Hamdard began with the establishment of a small unani clinic in the year 1906 by Hakeem Hafiz Abdul Majeed, a practitioner with the vision of making the practice of Unani medicine a scientific discipline. In 1972, Hamdard College of Pharmacy was setup with the objective of providing and training in all branches of Pharmacy, which was given the Deemed University status in the year 1989. Currently, Jamia Hamdard is engaged in imparting high quality teaching and research in the disciplines of Pharmacy, Science, Medicine, nursing, management, Information technology, Allied Health Sciences, Islamic studies etc. In recognition of its excellent and academic achievements, Jamia Hamdard has been accredited with 'A' Grade by National Accreditation and Assessment Council (NAAC).

The Department of Pharmaceutical Chemistry is one of the core Department, engaged in research related to drug development and discovery. The Department was formally established in 1986 with the M. Pharm. (Pharmaceutical Chemistry) and Ph.D. programme. The University started two year M Pharm (Pharm Analysis) course in the academic year 2006. The courses are approved by the All Council for Technical Education (AICTE) and Pharmacy Council of India (PCI). Current areas of research can be broadly classified into following categories: Anticancer, Drug Designing, Antimalarial, Anticonvulsant, Anti-inflammatory, Natural Chemistry, Hepatoprotective drugs, etc. The Department is well equipped with modern wet laboratories along with analytical instruments like NMR (Bruker Avance-400MHz), IR (Bruker alpha-T spectrophotometer), Mass (Waters SYNAPT UPLC-MS/MS) etc. The Department has

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

about 58 national and 202 international publications in various reputed journals with an average impact factor of 2.0 during last five years. The Department has also received research grants to the tune of more than Rs. 2.5 crores from various funding agencies like UGC/ ICMR/ AYUSH/ AICTE/ DST/ DBT. The students are well placed in various industries (Ranbaxy Research Laboratories-Diachi, Sun-Pharma, Nicolas Piramal, Jubiliant Organosys, Dabur etc) and Academic and Research Institutions through Placement cell.

Owing to the advent of computer aided drug design and discovery, nanotechnology, stem cell research, molecular diagnostics, translational medicine, reverse pharmacology etc., pharmaceutical research has attained new heights. Advances in assay and instrument technology have provided the means necessary to address the evolving needs of drug discovery. In order to provide proper direction and to channelize future pharma research and keeping the recent developments in mind, the seminar provides the right platform. The seminar will serve as a platform for interaction between young scholars and scientists from academia and industry with experienced scientists from various institutions. Eminent research personalities have been enlisted as resource persons. The outcomes of the seminar will direct the future foci to move ahead in diverse research areas for the benefit of mankind. The recent trends highlighting innovative and interesting topics will be discussed under the main theme of conference.

1. Antibiotics Resistance 2. Traditional therapies and natural products

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

3. Innovations in Drug formulations 4. Drug discovery, pharmacology and toxicology 5. Frontiers technology of drug discovery 6. Instrumentation in Drug discovery 7. Current trends in Medicinal Chemistry

Program-Schedule

2nd One Day National symposium on

New Horizons in Drug Discovery and Development 16 November 2015

09:00 – Registration

10:00am

10:00- Quran recitation

10:05am

10:05- Bouquet presentation

10:10am

10:10- Welcome Address by the Dr. M. Mumtaz Alam, Convener

10:20am

10:20- Pharmacy week introduction by Prof Farhan J Ahmad, IPA

10:30am

10:30-10:35am Address by the Prof Asghar Ali, Dean, Faculty of Pharmacy

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

10:35- Keynote address by Dr. Syed Tanvir Ali, Plant Head, Quantum Natural

11:00am

11:00- Vote of thanks by Prof. Anees A Siddiqui, Head, Department of Pharmaceutical

11:05am Chemistry

11:05- National Anthem

11:10am

11:10- High Tea

11:30am

Auditorium : Scientific Session-I

Chairman – Prof Anees A Siddiqui

Co-chairman –Dr Javed Ali; Dr. S. E. Haque

11:30 – Invited Lecture by Dr. Asif: Scientist, ICGEB, New Delhi

12:15pm Title: “Understanding biology of cell organelles in malaria parasite and development

of new anti-malarials”

12:15 – Invited Lecture by Dr. Rahul Jain: GM, Kusum Healthcare

01:00pm Title: “Smart drug delivery system”

01:00 – Lunch with Poster Presentation

02:00pm

Auditorium: Scientific Session-II

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Chairman -Prof Divya Vohora

Co-chairman –Dr. Sayeed Ahmad

02:00 – Invited Lecture by Dr. Suhail Parvez: Associate Professor, Jamia Hamdard

02:30pm Title: “Ion channel electrophysiology: An emerging technique in drug discovery”

02:30 – Invited Lecture by Dr. Ziaur Rahman: Associate Professor, Mangalayatan University,

03:00pm Aligarh

Title: “Polymorphism: Current trends in Medicinal Chemistry”

03:00 – Invited Lecture by Ms. Priyamvada Jain: Pharmaceutical Quality Advisor, YES

03:30pm Pharma Services

Title: “An introduction to regulatory affairs and current trends in formulation

development”

03:30 – Oral Presentations

04:00pm

04:00 – Tea

04:15pm

Scientific Session-III: Training Session

04:15 – Pharmacological Screening: by Dr. Abul K Najmi, Assistant Professor, Pharmacology,

05:00pm Jamia Hamdard

Chromatographic separation of Natural Products: by Dr. Showkat R Mir, Assistant

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Professor, Pharmacognosy, Jamia Hamdard

NMR Technique: by Dr. M. Shaquiquzzaman, Assistant Professor, Pharm Chemistry,

Jamia Hamdard

Nanoformulations: by Dr. Gaurav Jain, Assistant Professor, Pharmaceutics, Jamia

Hamdard

05:00– Invited Lecture by Tijjani Salihu, Jamia Hamdard

05:15pm Title: “Protein Chemistry”

05:15– Address by Prof. C. L. Kaul

05:20pm

05:20– Awards distribution for Best Poster (04; one in each category) and Best Oral

05:35pm Presentations (01) by Prof. R. K. Khar, President IPA

05:35– e-Poster Award distribution by by Prof. R. K. Khar, President IPA

05:40pm

05:40– Closing remarks by Prof. R. K. Khar, President IPA

05:50pm

05:50– Certificate distribution

06:00pm

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Poster Presentation: List of Presenting Author along with title and Abstract number

Presenting Author Title of the Abstract Abstract No AasiyUlErum Integration of Novel drug delivery system in traditional Unani therapies D-16 A.K. Najmi Alleviation of DOX induced nephrotoxicity by benazepril, quercetin and B-1 Bombyxmori Abdullah Adverse Effects of NewerAnti-Diabetic Drugs in Treatment of Type II B-2 Diabetes Mellitus Abidin L Natural boons for arthritis and their molecular targets D-11 Ahsan Ahmed Khan Synthesis and Anticonvulsant activity of Semicarbazone derivatives of C-15 some naturally occurring compounds Afrin Salma The role of DprE1 inhibitors for the management of anti-tubercular B-3 activity Akhtar Wasim Molecular docking in Medicinal Chemistry C-20 Aqil M. Utility of Terpenes in Transdermal delivery of an Anti-hypertensive agent A-6 Arya Ashwani Recent Advances in understanding of the Schizophrenia B-4 Asif Husain New Benzimidazole derivatives: Synthesis and in-vitro anticancer activity C-23 Chanda Ranjan Syntheses, characterization and neuropharmacological evaluation of some C-2 novel 3-(2-furanyl)-4,5-dihydro-5-substituted phenyl isoxazoles Choudhary Deepika Structure based designing and ADME-T studies of butenolide derivatives as potential agents against Receptor ICAM-1: A drug target for cerebral C-3 malaria Deepanshu Sharma Role of Cyclin dependent kinase (CDK) Inhibitor in Cancer: An overview B-6 Dinesh K. Mehta Antifungal evaluation of 2-amino-5-(2-nitrophenyl)-1, 3, 4-thiadiazole C-4 Divya Vohora Effect of Phosphoinositide-3 Kinase inhibitors in inflammatory diseases: B-12 The light at the end of the tunnel Farah Khan Natural mineral compound Jade in ash form [JAF] modulates the B-16 humoral innate immune response. Farah Iram Anticancer activity of New 1-(1H-Benzo[d]imidazol-2-yl)ethanone C-6 derivatives Geetika Ganjoo Role of Carvedilol compared to other β-Blockers in acute Myocardial B-7 infarction Gita Chawla Ketoprofen: An update ofchemistry and chemical modifications to reduce C-24 the gastrointestinal side effects. Hinna Hamid Development of Novel benzimidazole based GSK-3β inhibitors C-12 Presenting Author Title of the Abstract Abstract No

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Hooda Anil Recent advances of Nano-carrier on Herbal Drugs D-1 Iqbal Zeenat Development and validation of a RP-HPLC method to simultaneously detect lactone and carboxylate form of Topotecan along with A-7 Thymoquinone: Application to nanoparticulate system Jaspreet Kaur Anxiolytic activity of polyphenol fraction of peel extract of Punica D-2 granatum Linn in Mice Joon Nisha Herbal Emulgens D-3 Joon Ritu Phytosomes: A step ahead in the field of Phytomedicine D-8 Juveria Usmani Pathophysiology of Peptic ulcer and treatment with current therapy B-8 Kamran J Naquvi HPTLC Quantification of thymol in different extracts and volatile oil of D-4 Safoof-e-Muhazzil Khan Mohemmed Pyrazole derivatives in the treatment of cancer C-27 Faraz Mahfuz Alam Synthesis and antimicrobial activity of 3,5-substituted phenyl-3,3a,4,7- C-25 tetrahydro-2H-pyrazolo[3,4-c]pyridazines Mandeep Kaur Drug Discovery: Novel Technologies C-8

Manisha Pahal Stroke: A sudden loss of brain function B-9

Md Arman Arif Long term antihypertensive efficacy and safety of the oral Direct Renin B-10 Inhibitor (DRI) ALISKIREN Md Azhar Iqbal Design and synthesis of Novel Benzimidazole based fused heterocyclic C-1 derivatives as potential anticancer agents Md Jahangir Alam Synthesis, in vitro studies and molecular docking of novel Pyrazole C-7 derivatives as potential TNF-α inhibitor and anti-inflammatory activity Mohammad Ashif Novel development and conventional technique for solubility A-1 Khan enhancement: Melt-Sonocrystallization Mohd Javed Naim Synthesis of some New Thiazolo [2, 3-a] Pyrimidine derivatives as Anti- C-9 inflammatory and anti-microbial agents Mohd. Vaseem Impact analysis of Merger and acquisition in Pharmaceutical industry B-18 Ismail Mujeeb M Supercritical carbon dioxide assisted extraction of solasodine from D-6 Solanum nigrum Linn Presenting Author Title of the Abstract Abstract No Nasa Praveen Liquisolid: A novel technique of enhancing drug solubility of poorly A-2

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

aqueous soluble drugs Nazim Hussain Anticancer activity of Methanolic extract of Cordia dichotoma bark D-15 Neha Mallick Stabilization of superparamagnetic iron oxide nanoparticles- Development A-10 and in vitro localization study for magnetic drug targeting applications Parminder Nain Anti-atherogenesis and anti-hyperlipidemic activity of Emblica officinalis B-11 leaves extract in albino rats fed with high fat diet Pooja Verma Hypertension & its treatment including Herbal drugs D-7 Rahmat Ali Development of non-purine Xanthine oxidase inhibitors as structural C-10 analogues of Febuxostat for management of Gout and Hyperuricemia Reena Sheoran Nanotechnology in Cancer diagnostics and therapeutics A-3 Rina Das Synthesis of 2-amino-5-(2-nitrophenyl)-1, 3, 4-Thiadiazole using C-11 Ultrasound Irridation Technique. Sadaf Ali Suvorexant: An overview C-13 Sajal Chhabra In-Silico studies of Pyridazine derivatives as COX-2 Inhibitors C-16 Sandeep Kumar Benzimidazole as anticancer agent C-22 Sandhya Bawa Hitches of Gout: As Xanthine Oxidase Inhibitors C-21 Seemi Siddiqui RP-HPLC Method for Estimation and Stress Degradation Study of C-28 Paclitaxel Sharma R. K. Densitometric validation and optimization of Polyphenols in Phyllanthus D-13 maderaspatensis Linn by High-Performance Thin-layer Chromatography Sharma Anjali Floating drug delivery system A-4 Shilpa Parmar Gliptins- a new class of oral anti-diabetic agents C-17 Siddiqui N Druggability issues with bioactive leads from herbal medicines D-12 Sindhwani G. Plant tissue culture: A revolutionary technique in advancement of Herbal D-9 Drug Soni Singh Production and Optimization of Astaxanthin by Phaffia rhodozyma under D-14 Submerged Fermentation Soodan S Nutraceuticals as alternative medicines D-10 Sushama Functionalized bioceramic nanoparticles of Risedronate for synergistic A-8 Talegaonkar targeting to bone Swarna Dabral Monitoring and Reporting of adverse drug reactions in In Patient B-13 Department (IPD) in Mahant Indresh Hospital, Dehradun, Uttarakhand. Presenting Author Title of the Abstract Abstract No Syed Ehtaishamul Effect of Resveratrol and Black tea extract on Cellular architecture of B-19 Haque Rats myocardium

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Talha Jamal Efficacy and Tolerability of Meloxicam, a COX-2 preferential C-18 Nonsteroidal anti-Inflammatory Drug Teena Sharma Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of A-5 Poorly water Soluble Drugs Waseem A. Siddiqui Amelioration of hyperglycemia, hyperlipidemia and oxidative damage in B-17 streptozotocin-induced type 1 diabetic rat model Yadav Mamta Influence of nano-technology on Herbal Drugs D-5 Zameer S. Letrozole and Anastrazole (But not Exemestane) impairs spatial learning and memory by modulating Hippocampal DICKKOPF-1 and sclerostin in B-14 female mice Zulphikar Ali Synthesis & docking studies of quinoxaline clubbed 1,3,4-oxadiazole C-19 derivatives as non-ulcerogenic anti-inflammatory agents

Oral Presentation: List of Presenting Author along with title and Abstract number

Presenting Author Title of the Abstract Abstract No Ashwini Dinodia Angina pectoris: An overview OB-5 Mohd Akhtar Antidepressant like effect of Irbesartan in unpredictable chronic mild OB-15 stress induced depression in mice Neelima Shrivastava Recent development in the discovery of benzimidazole as anti-cancer OC-26 agent and their synthetic approaches Ozair Alam Design, synthesis, molecular docking and molecular dynamics of OC-5 pyrazoline derivatives as potential anti-inflammatory agents Saima Amin Polymeric nanoparticles for oral delivery of Cilnidipine. OA-9 Syed Shafi Anti-malarial and anticancer activities of spiroisoxazoline analogues of OC-14 artemisinin

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

Best Oral and Poster Presentation:

Best Oral Presenter: Dr. Ozair Alam, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062 (OC-5)

Best Poster Presenter in Category-A: Mr. Praveen Nasa, Department of Pharmaceutical Education & Research, B.P.S. Mahila Vishwavidyalaya, Khanpur Kalan, Sonipat, (Haryana), India (Poster no: A-2)

Best Poster Presenter in Category-B: Zameer S, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062 (Poster no: B-14)

Best Poster Presenter in Category-C: Sandeep Kumar, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062 (Poster no: C-22)

Best Poster Presenter in Category-D: Nahida, Department of Pharmacognosy, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062 (Poster no: D-12)

Dr. Ozair Alam & Mr. Praveen nasa receiving awards for Best Oral Presentation and Best Poster Presentation

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

CONFERENCE AT A GLANCE:

INAUGURATION

VALEDICTORY

SCIENTIFIC SESSION:

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

AWARDS DISTRIBUTION:

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch New Horizons in Drug Discovery & Development-2 16TH November, 2015

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Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch