Product Guide Effective January 2021

View the most current catalog electronically at www.neuroscienceinc.com

Product availability subject to change without notice. 1 Copyright © 2019 NeuroScience Table of Contents Alphabetical Product Listing NeuroScience...... 3 AdreCor...... 9 NeuroScience Network Categories...... 4 AdreCor with Licorice Root...... 10 Catecholamine Products...... 5 AdreCor with SAMe...... 10 Balance D...... 5 Daxitrol Essential...... 6 Alpha GABA...... 25 Focus DL...... 6 Alpha GABA PM...... 26 Catecholamine Product Overview...... 8 Avipaxin...... 19 NeuroAdrenal Products...... 9 AdreCor...... 9 Balance D...... 5 AdreCor with Licorice Root...... 10 Calm CP...... 11 AdreCor with SAMe...... 10 Calm G...... 20 Calm CP...... 11 Calm PRT...... 11 Calm PRT...... 11 ExcitaPlus...... 12 Daxitrol Essential...... 6 NeuroAdrenal Product Overview...... 13 Digest DTX...... 15 NeuroEnteric Products...... 15 Digest DTX...... 15 ExcitaPlus...... 12 NeuroBiota...... 16 Focus DL...... 6 NeuroEnteric Product Overview...... 18 GABA Trex...... 26 NeuroImmune Products...... 19 Avipaxin...... 19 Kavinace OS...... 20 Calm G...... 20 Kavinace OS Emulsion...... 21 Kavinace OS...... 20 NeuroBiota...... 16 Kavinace OS Emulsion...... 21 NeuroImmune Product Overview...... 23 Serene...... 27 Serotonin/GABA Products...... 25 SeroTrex...... 27 Alpha GABA...... 25 TravaCor...... 28 Alpha GABA PM...... 26 GABA Trex...... 26 TravaGen...... 28 Serene...... 27 SeroTrex...... 27 TravaCor...... 28 TravaGen...... 28 Serotonin/GABA Product Overview...... 29 Pathway Biochemistry Guide...... 31 Quality Management...... 34 NeuroSelect Technology...... 35 Product Ordering and Shipping...... 37 Innovative and integrative Consistent products, An approach that delivers results consistent results As a professional-grade brand, our foremost goal NeuroScience embraces the expectations of a is delivering premium supplements containing rigorously regulated professional grade supplement amino acids, botanicals, vitamins, and minerals brand. In addition to using FDA-inspected that contain impactful amounts of ingredients in a manufacturers that are cGMP (current good practical daily serving. We never design products manufacturing practices) compliant, NeuroScience with specific price points in mind. orders impartial third-party testing to verify Understanding health is maintained between label ingredient amounts are met, inspect for the nervous, endocrine, and immune systems— microbial contaminants, and test for heavy metal while also recognizing clinical symptoms are contamination. We believe our comprehensive multifactorial—NeuroScience products are Quality Management System ensures consistent formulated and organized into the network products that deliver consistent results. impacted within our multi-system approach: Catecholamine, NeuroAdrenal, NeuroEnteric, NeuroImmune, and Serotonin/GABA.

3 NeuroScience Network Categories

Catecholamine

• Cognition/Focus • Energy • Mood • Weight Management

NeuroAdrenal

• Adrenal • Immune • Anxiousness/Stress • Mood • Cognition/Focus • Sleep • Energy • Weight Management

NeuroEnteric

• Anxiousness/Stress • Immune • Gut • Mood

NeuroImmune

• Anxiousness/Stress • Sleep • Cognition/Focus • Vision • Immune

Serotonin/GABA

• Anxiousness/Stress • Mood • Sleep

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 4 Best Catecholamine Balance D Seller (PEA, Dopamine, Norepinephrine, Epinephrine) Contains ingredients important A class of neurotransmitters responsible for for the synthesis of dopamine, many functions in the nervous and endocrine a catecholamine important for systems1 positive affect, mood, cognition, and craving control* Products in this category may be recommended for:

• Cognition/Focus

• Energy Item Size Serving size Servings/container • Mood 2067 60 Capsules 2 Capsules 30 • Weight Management

Key Ingredients: • N-acetyl-L-cysteine • N-acetyl-L-tyrosine • Mucuna cochinchinensis seed extract (99% L-DOPA) • Vitamins B and C

Suggested Use Take 1-2 capsules one to two times daily Supplement Facts or as directed by your healthcare provider. Serving Size: 2 Capsules Do not exceed suggested use. Servings Per Container: 30 This product has a tamper evident seal under the cap. Do not use if seal is broken Amount Per Serving % Daily Value or missing. Store at room temperature, in Vitamin C (as ascorbic acid) 200 mg 222% a dry place. Vitamin B6 0.5 mg 29% If you are pregnant or nursing, consult your (as pyridoxal 5'-phosphate) healthcare provider before use. Keep out of Folate 240 mcg DFE 60% reach of children. (as L-5-methyltetrahydrofolate, calcium salt‡) Selenium (as L-selenomethionine) 70 mcg 127% NeuroScience Quality Proprietary Blend 1.15 g † Consistent products, consistent N-acetyl-L-cysteine, N-acetyl-L-tyrosine, results. Scan to learn more. and Mucuna cochinchinensis extract (seed) Balance D (99% L-DOPA). † Daily Value not established. ‡ Magnafolate is a registered trademark of Lianyungang Dietary Supplement Jinkang Pharmaceutical Technology Co., Ltd. Other ingredients: Vegetable capsule (hypromellose, Catecholamine water), microcrystalline cellulose, magnesium stearate (vegetable source), silica, and dicalcium phosphate. Distributed by: Osceola, WI 54020 +1-888-342-7272 60 CAPSULES www.neuroscienceinc.com L2067BD60.12

Reference 1. Eisenhofer G, et al. Pharmacol Rev. 2004;56(3):331-49.

*These statements have not been evaluated by the Food and Drug Administration. 5 This product is not intended to diagnose, treat, cure or prevent any disease. Daxitrol Essential Focus DL Contains ingredients important Contains the precursor to PEA, for craving reduction, satiety, a neuromodulator important for and breakdown of fat stores* attention and cognition*

Item Size Serving size Servings/container Item Size Serving size Servings/container 20021 120 Capsules 3 Capsules 40 20003 60 Capsules 2 Capsules 30

Key Ingredients: Key Ingredients: • N-acetyl-L-cysteine • DL-phenylalanine • L-phenylalanine • Green tea (Camellia sinensis) leaf extract (65% EGCG) • 5-HTP (from Griffonia simplicifolia seed extract) • Mucuna cochinchinensis seed extract (99% L-DOPA) • Coleus forskohlii root extract (38% forskolin) • Huperzia serrata aerial parts (standardized to 1% huperzine A)

Suggested Use Take 1-3 capsules three times daily or as directed Supplement Facts by your healthcare provider. Do not exceed suggested use. Serving Size: 3 Capsules This product has a tamper evident seal under the cap. Suggested Use Servings Per Container: 40 Do not use if seal is broken or missing. Store at room Take 1-2 capsules one to two times daily or as Supplement Facts Amount Per Serving % Daily Value temperature, in a dry place. directed by your healthcare provider. Do not Serving Size: 2 Capsules If you are pregnant or nursing, consult your healthcare Chromium (as chromium nicotinate 200 mcg 571% Servings Per Container: 30 provider before use. Keep out of reach of children. exceed suggested use. glycinate chelate) This product has a tamper evident seal under Proprietary Blend 1.77 g † Amount Per Serving % Daily Value the cap. Do not use if seal is brokenN-acetyl-L-cysteine, or missing. L-phenylalanine, Green tea extract NeuroScience Quality Store at room temperature, in a dry(Camellia place. sinensis) (leaf) (65% epigallocatechin gallate), DL-phenylalanine 1 g † Consistent products, consistent 5-hydroxytryptophan (from Griffonia simplicifolia seed results. Scan to learn more. If you are pregnant or nursing, consultextract), your extract (seed) (99% Mucuna cochinchinensis † Daily Value not established. healthcare provider before use. KeepL-DOPA), out ofColeus forskohlii root extract (root) (38% forskolin), reach of children. and Huperzia serrata extract (aerial parts) (1% huperzine A). Other ingredients: Microcrystalline cellulose, ™ † Daily Value not established. vegetable capsule (hypromellose, water), and magnesium stearate (vegetable source). Daxitrol Essential Other ingredients: Vegetable capsule (hypromellose, water), Dietary Supplement NeuroSciencemicrocrystalline Quality cellulose, and magnesium stearate Phenylketonurics: Contains phenylalanine. Consistent products,(vegetable consistent source). Catecholamine results. Scan to learnPhenylketonurics: more. Contains phenylalanine. Distributed by: Osceola, WI 54020 +1-888-342-7272 ™ 6 59468 10140 0 120 CAPSULES www.neuroscienceinc.com FocusL20021DE120.10 DL Dietary Supplement Catecholamine

Distributed by: Osceola, WI 54020 +1-888-342-7272 6 59468 10119 6 60 CAPSULES www.neuroscienceinc.com L20003FD60.11

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 6 Catecholamine Ingredient Index

5-HTP (5-hydroxytryptophan): Crosses the blood-brain barrier and is the precursor to serotonin1* Chromium: A mineral nutrient that serves as a cofactor in the action of insulin6* Folate (as 5-MTHF): Necessary vitamin in the development and regulation of the nervous system, including the synthesis of neurotransmitters7-9* Forskolin: Botanical that stimulates production of cyclic adenosine monophosphate (cAMP), important for the activation of hormone- sensitive lipase, an enzyme that breaks down fat stores10-11* Green tea leaf extract: Epigallocatechin gallate (EGCG) is a polyphenol in green tea that is thought to increase energy expenditure and fat oxidation12* Huperzine A: Slows the breakdown of the neurotransmitter acetylcholine by inhibiting the enzyme acetylcholinesterase13* L-methionine: Essential amino acid precursor to S-adenosyl-L- methionine (SAMe), an important cofactor in the synthesis of the catecholamines14,15* L-phenylalanine: Precursor to phenylethylamine (PEA) and the catecholamines dopamine, norepinephrine, and epinephrine16 L-tyrosine: Precursor to the catecholamines including dopamine, norepinephrine, and epinephrine16 Manganese: Essential metal that is important for energy metabolism and immune activity17* Mucuna cochinchinensis (99% L-DOPA): L-DOPA crosses the blood- brain barrier and is the direct precursor to the neurotransmitter dopamine18,19 N-acetyl-L-cysteine: Precursor to L-cysteine, which is required for the synthesis of glutathione, an endogenous antioxidant20,21 Selenium: Micronutrient that helps to comprise selenoproteins; these proteins are crucial for brain function and for enzymes such as glutathione peroxidase22* Vitamin B6: This vitamin is an essential cofactor in the synthesis of neurotransmitters23* Vitamin C: This vitamin acts as an essential cofactor in the synthesis of neurotransmitters24* Zinc: Essential micronutrient that is important for synaptic plasticity and is commonly found within neurons in the cerebral cortex27*

References on page 38.

*These statements have not been evaluated by the Food and Drug Administration. 7 This product is not intended to diagnose, treat, cure or prevent any disease. Catecholamine Product Overview

Balance D Daxitrol Essential Focus DL

Clinical Cognition/Focus • •

Energy • Mood • Weight Management • • Biomarker** Dopamine      

Epinephrine  

Norepinephrine   

PEA      Ingredients 5-HTP •

Bacopa monnieri Chromium •

DL-phenylalanine •

Folate •

Forskolin •

Green tea leaf extract •

Huperzine A •

L-methionine L-phenylalanine •

L-tyrosine Manganese Mucuna cochinchinensis (99% L-DOPA) • •

N-acetyl-L-cysteine • •

N-acetyl-L-tyrosine • Selenium • Vitamin B6 • Vitamin C • Zinc Description Dosage Form Capsules Capsules Capsules Available Sizes 60 Capsules 120 Capsules 60 Capsules Serving Size 2 Capsules 3 Capsules 2 Capsules

Suggested Use (Do not exceed suggested use) 1-2 QD-BID 1-3 TID 1-2 QD-BID

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 8 Best NeuroAdrenal AdreCor Seller In response to stress, the sympathetic Contains non-glandular nervous system (SNS) and hypothalamic- ingredients important for pituitary-adrenal (HPA) axis signal to adrenal health and reducing the adrenals to release catecholamines stress-induced fatigue* (norepinephrine and epinephrine) and cortisol.1 Prolonged stress is associated with dysregulation of the HPA axis, which can affect catecholamine and cortisol levels.2

Products in this category may be recommended for: Item Size Serving size Servings/container 2096 90 Capsules 30 3 Capsules • Adrenal 2044 180 Capsules 60 • Anxiousness/Stress

• Cognition/Focus Key Ingredients: • L-methionine • Energy • L-tyrosine • Immune • L-histidine • Mood • Rhodiola rosea root extract (5% rosavins) • Green tea leaf extract (Camellia sinensis) (65% EGCG) • Sleep • Vitamins B and C • Weight Management

Suggested Use Take 1-3 capsules one to two times daily or as Supplement Facts directed by your healthcare provider. Do not exceed Serving Size: 3 Capsules suggested use. Servings Per Container: 30

This product has a tamper evident seal under the cap. Amount Per Serving % Daily Value Do not use if seal is broken or missing. Store at room temperature, in a dry place. Vitamin C (as ascorbic acid) 300 mg 333% Niacin (as niacinamide) 6 mg NE 38% If you are pregnant or nursing, consult your healthcare Vitamin B6 (as pyridoxal 5'-phosphate) 12 mg 706% provider before use. Keep out of reach of children. Folate (as L-5-methyltetrahydrofolate, 230 mcg DFE 58% calcium salt‡) Vitamin B12 (as methylcobalamin) 60 mcg 2500% Pantothenic acid (as D-calcium pantothenate) 300 mg 6000% NeuroScience Quality Magnesium (as magnesium bisglycinate chelate) 14 mg 3% Consistent products, consistent Zinc (as zinc bisglycinate chelate) 3 mg 27% results. Scan to learn more. Proprietary Blend 1.3 g † L-methionine, L-tyrosine, L-histidine, Rhodiola rosea extract ™ (root) (5% rosavins), and Green tea extract (Camellia sinensis) AdreCor (leaf) (65% epigallocatechin gallate). ‡ Magnafolate is a registered trademark of Lianyungang † Daily Value not established. Jinkang Pharmaceutical Technology Co., Ltd. Dietary Supplement Other ingredients: Vegetable capsule (hypromellose, water), NeuroAdrenal organic rice concentrate, and citric acid.

Distributed by: Osceola, WI 54020 +1-888-342-7272 90 CAPSULES www.neuroscienceinc.com L2096AC90.15

Label size: 7 x 2.75in References 1. Lee D, et al. BMB Rep. 2015;48(4):209-16 2. Krizanova O, et al. Stress. 2016;19(4):419-28.

*These statements have not been evaluated by the Food and Drug Administration. 9 This product is not intended to diagnose, treat, cure or prevent any disease. AdreCor with AdreCor Licorice Root with SAMe Increases cortisol levels Contains non-glandular and provides non-glandular ingredients important for ingredients important for adrenal health and mood* adrenal health, energy, wakefulness, and stress management*

Item Size Serving size Servings/container Item Size Serving size Servings/container 2097 90 Capsules 3 Capsules 30 2098 30 Capsules 1 Capsule 30

Key Ingredients: Key Ingredients: • Glycyrrhizic acid (from Licorice root extract) • Adomet® (SAMe) • L-histidine • L-tyrosine • L-methionine • Rhodiola rosea root extract (5% rosavins) • L-tyrosine • Green tea leaf extract (Camellia sinensis) (65% EGCG) • Rhodiola rosea root extract (5% rosavins) • Vitamins B and C • Green tea leaf extract (Camellia sinensis) (65% EGCG) • Vitamins B and C

Suggested Use Suggested Use Take 1-3 capsules one to two times daily or as Take 1 capsule one to twoSupplement times daily or as Facts Supplement Facts Serving Size: 1 Capsule directed by your healthcare provider. Do not exceed Serving Size: 3 Capsules directed by your healthcare provider. Do not Servings Per Container: 30 suggested use. exceed suggested use. Servings Per Container: 30 This product has a tamper evident seal under the cap. This product has a tamper evident seal under Amount Per Serving % Daily Value Amount Per Serving % Daily Value Do not use if seal is broken or missing. Store at room the cap. Do not use if seal is broken or missing. Vitamin C (as ascorbic acid) 50 mg 56% temperature, in a dry place. Store at room temperature,Vitamin in Ca (asdry ascorbic place. acid) 300 mg 333% Niacin (as niacinamide) 2 mg NE 13% Niacin (as niacinamide) 6 mg NE 38% Vitamin B6 (as pyridoxal 5'-phosphate) 4 mg 235% If you have cardiovascular concerns or if you are If you are pregnant or nursing,Vitamin B6 consult (as pyridoxal your 5'-phosphate) 12 mg 706% Folate (as L-5-methyltetrahydrofolate, 109 mcg DFE 27% ‡ pregnant or nursing, consult your healthcare provider healthcare provider beforeFolate use. (as KeepL-5-methyltetrahydrofolate, out of 220 mcg DFE 55% calcium salt ) before use. Keep out of reach of children. reach of children. calcium salt‡) Vitamin B12 (as methylcobalamin) 20 mcg 833% Pantothenic acid (as D-calcium pantothenate) 100 mg 2000% Vitamin B12 (as methylcobalamin) 60 mcg 2500% Calcium (from calcium oxide, D-calcium 25 mg 2% Pantothenic acid (as D-calcium pantothenate) 300 mg 6000% pantothenate, calcium chloride and dicalium phosphate) NeuroScienceMagnesium (as magnesiumQuality glycinate) 14 mg 3% Magnesium (as magnesium bisglycinate chelate) 4.7 mg 1% NeuroScience Quality ConsistentZinc (as products, zinc bisglycinate consistent chelate) 3 mg 27% Zinc (as zinc bisglycinate chelate) 1 mg 9% Consistent products, consistent results. Scan to learn more. results. Scan to learn more. Glycyrrhizic acid (from Licorice root extract) 120 mg † S-adenosyl-L-methionine (as s-adenosyl- 200 mg † Proprietary Blend 587 mg † TM L-methionine disulfate p-toluensulfonate**) ™ L-histidine, L-methionine, L-tyrosine, Rhodiola rosea extract Proprietary Blend 96 mg † (root) (5% rosavins), and Green tea extract (Camellia sinensis) L-tyrosine, Rhodiola rosea extract (root) (5% rosavins), and AdreCor ® AdreCor ‡ Magnafolate is a registered(leaf) (65% trademark epigallocatechin of Lianyungang gallate). Green tea extract (Camellia sinensis) (leaf) (65% Jinkang Pharmaceutical Technology Co., Ltd. with SAMe ‡ with Licorice Root epigallocatechin gallate). Magnafolate is a registered trademark of Lianyungang Jinkang Pharmaceutical Technology Co., Ltd. ** Adomix® is protected† Daily by U.S. Value Patent not No. established.4,911,939. † Daily Value not established. Adomix® Registered trademarks of Gnosis S.p.A., Milan, Italy. Dietary Supplement Dietary Supplement Other ingredients: Vegetable capsule (hypromellose, water), micro- Other ingredients: Vegetable capsule (hypromellose, water), micro- crystalline cellulose, and magnesium stearate (vegetable source). NeuroAdrenal crystalline cellulose, and magnesium stearate (vegetable source). NeuroAdrenal Distributed by: Osceola, WI 54020 Distributed by: Osceola, WI 54020 +1-888-342-7272 +1-888-342-7272 90 CAPSULES 1 59468 10110www.neuroscienceinc.com8 L2097ACL90.1330 CAPSULES www.neuroscienceinc.com L2098ACS30.11

Label size: 7 x 2.75in

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 10 Best Calm CP Seller Calm PRT Decreases cortisol levels Contains ingredients important and provides ingredients for sleep, regulating the important for calm, sleep, and stress response, and reducing management of blood sugar* anxiousness*

Item Size Serving size Servings/container Item Size Serving size Servings/container 2099 60 Capsules 2 Capsules 30 20050 90 Capsules 4 Capsules 22

Key Ingredients: Key Ingredients: • Lagerstroemia speciosa (Banaba) leaf extract (18% corosolic acid**) • Rhodiola rosea root extract (9%-15% rosavins) • Phosphatidylserine • Phosphatidylserine • Glycine • Glycine • Taurine • Taurine

Suggested Use Suggested Use Take 2 capsules one to two times daily or Take 3-4 capsules on an empty stomach one to two Supplement Facts Supplement Facts as directed by your healthcare provider. times daily or as directed by your healthcare provider. Serving Size: 2 Capsules Serving Size: 4 Capsules Do not exceed suggested use. Do not exceed suggested use. Servings Per Container: 30 Servings Per Container: 22 If you are pregnant or nursing, consult your This product has a tamper evident seal This product has a tamper evident seal under the cap. Suggested Use: Take 3-4 capsules one to Amount Per Serving % Daily Value under the cap. Do not use if seal is broken Do not use if seal is broken or missing. Store at room healthcareAmount Per providerServing before use. % Daily Value two times daily or as directed by your or missing. Store at room temperature, temperature, in a dry place. Proprietary Blend 667 mg † ThisProprietary product Blend has a tamper evident1.88 seal g under † healthcare provider. Do not exceed in a dry place. Phosphatidylserine 50%‡, L-glycine, L-taurine, Rhodiola rosea extract (root) (10% rosavins, providing suggested use. If you are pregnant or nursing, consult your healthcare the cap. Do not use if seal is broken‡ or missing. and Banaba extract (Lagerstroemia speciosa) 112.5 mg of rosavins), Phosphatidylserine 50% , L-glycine, If you are pregnant or nursing, consult provider before use. Keep out of reach of children. and L-taurine. your healthcare provider before use. (leaf) (18% Corosolic acid). Keep out of reach of children. Supplement Facts Calm PRT contains ingredients that when taken at Serving Size: 4 Capsules Keep out of reach of children. † Daily Value not established. below the suggested use may cause over-excitation, † Daily Value not established. Store at room temperature, in a dry place. Servings Per Container: 22 jitteriness, or agitation. Other ingredients: Microcrystalline cellulose, vegetable capsule Other ingredients: Organic rice concentrate, (hypromellose,Distributed water), by NeuroScience magnesium stearate (vegetable source), TM Amount Per Serving % Daily Value vegetable capsule (hypromellose, water), andOsceola, silica. WI 54020 • 888-342-7272 NeuroScience Quality Consistent products, consistent NeuroScience Quality and silica. www.neuroscienceinc.com Calm PRT Proprietary Blend 1.88 g † Consistent products, consistent results. Scan to learn more. ® Rhodiola rosea root extract (standardized to 10% results. Scan to learn more. ™ ‡ This product uses SerinAid® (Phosphatidylserine). Dietary Supplement rosavins, providing 112.5 mg of rosavins), Calm CP ® ‡ Calm PRT SerinAid is a registered trademark of Chemi Nutra. Phosphatidylserine , Glycine, and Taurine. Dietary‡ This product Supplement uses SerinAid® (Phosphatidylserine). ® Dietary Supplement ‡ SerinAid® is a registered trademark of Chemi Nutra. SerinAid is a registered trademark of Chemi Nutra. † Daily Value not established. NeuroAdrenal NeuroAdrenal Other Ingredients: Vegetable capsule (Hypromellose, Distributed by: Osceola, WI 54020 Distributed by: Osceola, WI 54020 water), Microcrystalline cellulose, Silicon dioxide, and +1-888-342-7272 +1-888-342-7272 Magnesium stearate (vegetable source). 606 CAPSULES59468 10180 6 www.neuroscienceinc.com 90L2099CCP60.14 CAPSULES www.neuroscienceinc.com L20050PRT90.04

Label size: 6 x 2.75in Label size: 7 x 2.75in NeuroAdrenal 6 59468 10180 6 90 Capsules L20050PRT90.02

*These statements have not been evaluated by the Food and Drug Administration. 11 This product is not intended to diagnose, treat, cure or prevent any disease. ExcitaPlus NeuroAdrenal Ingredient Index Contains non-glandular Banaba leaf: Botanical that contains corosolic acid, a compound that selectively inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), ingredients important for an enzyme that catalyzes the conversion of cortisone into cortisol28,29* adrenal health and reducing Folate (as 5-MTHF): Necessary vitamin in the development and stress-induced fatigue* regulation of the nervous system, including the synthesis of neurotransmitters7-9* Provides over three times the Glycine: Major inhibitory neurotransmitter that crosses the blood- L-tyrosine and six times the brain barrier and binds receptors that regulate temperature during 30,31 Rhodiola per capsule compared sleep * Green tea leaf extract: Epigallocatechin gallate (EGCG) is a to AdreCor polyphenol in green tea that provides antioxidant protection through its ability to scavenge free radicals and metal ions32,33*

Item Size Serving size Servings/container L-histidine: Precursor to histamine, a neurotransmitter in the central nervous system that has an important role in the release of pituitary 2069 120 Capsules 2 Capsules 60 hormones and wakefulness34* Licorice root extract: Glycyrrhetinic acid (metabolite of glycyrrhizic acid) binds 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) to inhibit the breakdown of cortisol35,36* Key Ingredients: L-methionine: Essential amino acid precursor to S-adenosyl-L- • L-tyrosine methionine (SAMe), an important cofactor in the synthesis of the catecholamines14,15* • Rhodiola rosea root extract (5% rosavins) L-tyrosine: Precursor to the catecholamines including dopamine, • L-methionine norepinephrine, and epinephrine16 • Mucuna cochinchinensis seed extract (99% L-DOPA) Magnesium: Mineral found in the body that is important for 37 • Vitamins B and C neurotransmitter release and energy metabolism * Manganese: Essential metal that is important for energy metabolism and immune activity17* Mucuna cochinchinensis (99% L-DOPA): L-DOPA crosses the blood- brain barrier and is the direct precursor to the neurotransmitter dopamine18,19 Niacin (B3): Vitamin in its active form is important for the synthesis of Suggested Use 38 Take 1-2 capsules one to two times daily or as directed Supplement Facts neurotransmitters * by your healthcare provider. Do not exceed suggested use. Serving Size: 2 Capsules Servings Per Container: 60 This product has a tamper evident seal under the cap. Pantothenic acid (B5): Involved in the synthesis of neurotransmitters Do not use if seal is broken or missing. Store at room Amount Per Serving % Daily Value and is the precursor to coenzyme A (CoA), an essential coenzyme for temperature, in a dry place. 39 If you are pregnant or nursing, consult your healthcare Vitamin C (as ascorbic acid) 67 mg 74% energy production and hormone synthesis * provider before use. Keep out of reach of children. Niacin (as niacinamide) 20 mg NE 125% Vitamin B6 (as pyridoxal 5’-phosphate) 17 mg 1000% Phosphatidylserine: Component of cell membranes important for Folate (as L-5-methyltetrahydrofolate, 240 mcg DFE 60% ‡ receptor-mediated interactions; phosphatidylserine is thought to NeuroScience Quality calcium salt ) Consistent products, consistent Pantothenic acid (as D-calcium pantothenate) 40 mg 800% interact with cell membranes in order to dampen hypothalamic results. Scan to learn more. Zinc (as zinc bisglycinate chelate) 6.7 mg 61% signaling and regulate the stress response40,41* Manganese (as manganese sulfate) 2.7 mg 117% Proprietary Blend 1.1 g † Rhodiola: Botanical that is considered an adaptogen because of its L-tyrosine, Rhodiola rosea extract (root) (5% rosavins), L-methionine, ability to increase the body’s resistance to stressors42* ™ and Mucuna cochinchinensis extract (seed) (99% L-DOPA). ‡ Magnafolate is a registered trademark of Lianyungang ExcitaPlus Jinkang Pharmaceutical Technology Co., Ltd. Dietary Supplement † Daily Value not established. S-adenosyl-L-methionine (SAMe): SAMe is the universal methyl donor Other ingredients: Vegetable capsule (hypromellose, water), micro- in the body involved in the methylation of neurotransmitters14,15* NeuroAdrenal crystalline cellulose, and magnesium stearate (vegetable source). Distributed by: Osceola, WI 54020 Taurine: Neuroprotective amino acid that provides antioxidant +1-888-342-7272 43-45 120 CAPSULES www.neuroscienceinc.com L2069EXP120.11 protection and demonstrates GABA-A agonist activity * Vitamin B12: This vitamin is essential in the development and function of the nervous system and the formation of neurotransmitters46* Vitamin B6: This vitamin is an essential cofactor in the synthesis of neurotransmitters23* Vitamin C: This vitamin acts as an essential cofactor in the synthesis of neurotransmitters24* Zinc: Essential micronutrient that is important for synaptic plasticity and is commonly found within neurons in the cerebral cortex27*

References on page 38.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 12 NeuroAdrenal Product Overview

AdreCor AdreCor AdreCor ExcitaPlus with Licorice Root with SAMe Clinical Adrenal • • • • Cognition/Focus • Energy • • • Immune • Mood • Biomarker** Dopamine      Epinephrine        Norepinephrine        Cortisol       Ingredients Folate • • • • Green tea leaf extract • • • L-histidine • • Licorice root extract • L-methionine • • • L-tyrosine • • • • Magnesium • • • Manganese • Mucuna cochinchinensis (99% L-DOPA) • Niacin • • • • Pantothenic acid • • • • Rhodiola (5% rosavins) • • • • S-adenosyl-L-methionine (SAMe) • Vitamin B12 • • • Vitamin B6 • • • • Vitamin C • • • • Zinc • • • • Description Dosage Form Capsules Capsules Capsules Capsules Available Sizes 90 and 90 Capsules 30 Capsules 120 Capsules 180 Capsules Serving Size 3 Capsules 3 Capsules 1 Capsule 2 Capsules

Suggested Use (Do not exceed suggested use) 1-3 QD-BID 1-3 QD-BID 1 QD-BID 1-2 QD-BID

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. 13 This product is not intended to diagnose, treat, cure or prevent any disease. NeuroAdrenal Product Overview

Calm CP Calm PRT

Clinical Adrenal • • Immune • Sleep • • Weight Management • Biomarker** Epinephrine  Glycine   Norepinephrine  Taurine   Cortisol    Ingredients Banaba leaf extract • Phosphatidylserine • • Glycine • • Taurine • • Rhodiola (9%-15% rosavins) • Description Dosage Form Capsules Capsules Available Sizes 60 Capsules 90 Capsules Serving Size 2 Capsules 4 Capsules

Suggested Use (Do not exceed suggested use) 2 QD-BID 3-4 QD-BID

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 14 New NeuroEnteric Digest DTX Product The enteric nervous system contains 5x as Formulated with digestive many neurons as the spinal cord and helps enzymes and botanicals to relay messages from the brain to the gut.1-3 break the toxin-induced Proper gut health promotes balanced immune immune cycle through improved function, healthy neurotransmitter production, digestion, aided detoxification, 1 and improved digestion. and balanced immune function* Products in this category may be recommended for:

• Anxiousness/Stress

• Gut Item Size Serving size Servings/container 20046 90 Capsules 1 Capsule 90 • Immune

• Mood Key Ingredients: • Enzyme blend (Amylase, Lactase, Lipase, Protease, Acid Protease DS) • Cilantro leaf (Coriandrum sativum) • Apple cider vinegar • Turmeric (Curcuma longa, standardized to 30% curcuminoids)

If you are pregnant or nursing, consult your healthcare Suggested Use: Take 1 capsule before consuming provider before use. food or as directed by your healthcare provider. Do not This product has a tamper evident seal under the cap. exceed 10 capsules per day. Do not use if seal is broken or missing. Supplement Facts Keep out of reach of children. Serving Size: 1 Capsule Store at room temperature, in a dry place. Servings Per Container: 90 Distributed by NeuroScience, Osceola, WI 54020 Amount Per Serving % Daily Value 888-342-7272 • www.neuroscienceinc.com Amylase 133 mg (20,000 SKB) † TM Protease 25 mg (20,000 HUT) † Digest DTX Lactase 20 mg (2,000 ALU) † Dietary Supplement Lipase 13 mg (2,000 FIP) † Acid Protease DS 6 mg (500 HUT) † Proprietary Blend 280 mg † Cilantro (Coriandrum sativum) leaf, Apple cider vinegar, Turmeric (Curcuma longa) rhizome extract (standardized to 30% curcuminoids).

† Daily Value not established. Other Ingredients: Vegetable capsule (Hypromellose, NeuroEnteric water), Microcrystalline cellulose, and Magnesium 6 59468 10170 7 90 Capsules stearate (vegetable source). L20046DDTX90.03

References 1. Saulnier, D. et al. Gut Microbes. 2013 Jan-Feb;4(1):17-27. 2. Rao, M. And Gershon, M. Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):517–528. 3. Bansal, T. Proc Natl Acad Sci U S A. 2010.

*These statements have not been evaluated by the Food and Drug Administration. 15 This product is not intended to diagnose, treat, cure or prevent any disease. New NeuroBiota Product Combination of two uniquely designed blends of shelf-stable probiotics important for the gut-brain axis, improvement of mood, neurotransmitter synthesis, and balancing the immune response*

Item Size Serving size Servings/container 20049 30 Tablets 1 Capsule 30

Key Ingredients: • Probiotics

If you are pregnant or nursing, consult your healthcare Suggested Use: Take 1 capsule daily or as directed by your provider before use. healthcare provider. Do not exceed suggested use. This product has a tamper evident seal under the cap. Supplement Facts Do not use if seal is broken or missing. Serving Size: 1 Capsule Keep out of reach of children. Servings Per Container: 30 Store at room temperature, in a cool dry place. No refrigeration required. Amount Per Serving % Daily Value Distributed by NeuroScience Proprietary Blends 81 mg † Osceola, WI 54020 • 888-342-7272 TM ProBlend 24 billion CFUs † www.neuroscienceinc.com Lactobacillus casei (Lc-11), Lactobacillus acidophilus NeuroBiota (La-14), Lactobacillus paracasei (Lpc-37), Lactobacillus Dietary Supplement plantarum (Lp-115), Lactobacillus rhamnosus (GG), and Bifidobacterium lactis (BI-04) NeuroBlend 6 billion CFUs † Bifidobacterium longum (Rosell®-175), Lactobacillus helveticus (Rosell ® -52) , and Lactobacillus brevis (Lbr-135)

† Daily Value not established.

NeuroEnteric Other Ingredients: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, and Magnesium stearate 6 59468 10173 8 30 Capsules (vegetable source). L20049NB30.01

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 16 NeuroEnteric Ingredient Index

Apple cider vinegar: In vitro studies demonstrate apple cider vinegar balances the enteric microbiota and supports immune regulating properties through the downregulation of toxic protein expression and TNF-α and IL-6 expression77* Cilantro leaf (Coriandrum sativum): Coriandrum sativum is a peptide derived from cilantro leaf which promotes a balanced microbiota78* Enzyme blend (Amylase, Lactase, Lipase, Protease, Acid Protease DS): Blend of acid-stable, naturally-derived enzymes designed to optimize fundamental digestion* Probiotics: Living microorganisms that populate the gut to help support gut function, balance immune activity, and improve neurotransmitter synthesis79-81* Turmeric (Curcuma longa, 30% curcuminoids): Curcumin, a polyphenol in turmeric, contains notable immune regulating properties82*

References on page 38.

*These statements have not been evaluated by the Food and Drug Administration. 17 This product is not intended to diagnose, treat, cure or prevent any disease. NeuroEnteric Product Overview

Digest DTX NeuroBiota

Clinical Indication Anxiousness/Stress • Gut • • Immune • • Mood • Biomarker** GABA  Cortisol  Ingredients Apple cider vinegar • Cilantro leaf • Enzyme blend • Probiotics • Turmeric • Description Dosage Form Capsules Capsules Available Sizes 90 Capsules 30 Capsules Serving Size 1 Capsule 1 Capsule

Suggested Use 1 QD before consuming food 1 QD (Do not exceed suggested use)

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 18 NeuroImmune Avipaxin The sympathetic and parasympathetic Contains ingredients nervous systems work together with the involved in the synthesis and immune system to regulate the immune activity of acetylcholine, a response.1 Oxidative stress is directly linked to neurotransmitter important for learning, memory, and immune activation and can damage proteins, 2 downregulation of the immune lipids, and DNA. Long term immune system* activation can lead to imbalances in these systems and can contribute to symptoms such as fatigue, low mood, and sleep difficulties.1,3-5

Products in this category may be recommended for: Item Size Serving size Servings/container 20040 90 Capsules 3 Capsules 30 • Anxiousness/Stress

• Cognition/Focus

• Immune Key Ingredients: • Acetyl-L-carnitine • Sleep • Alpha-glycerylphosphorylcholine (50% alpha-GPC)

• Vision • Huperzia serrata (standardized to 1% huperzine A)

If you are pregnant or nursing, consult Suggested Use: Take 1-3 capsules one to two your healthcare provider before use. times daily or as directed by your healthcare provider. Do not exceed suggested use. This product has a tamper evident seal under the cap. Do not use if seal is Supplement Facts broken or missing. Serving Size: 3 Capsules Servings Per Container: 30 Keep out of reach of children. Store at room temperature, Amount Per Serving % Daily Value TM in a dry place. Proprietary Blend 1.82 g † Avipaxin Acetyl-L-carnitine HCl, Alpha-glycerylphosphoryl- Distributed by NeuroScience Dietary Supplement choline (50% Alpha-GPC), and Huperzia serrata Osceola, WI 54020 • 888-342-7272 aerial parts (standardized to 1% huperzine A). www.neuroscienceinc.com † Daily Value not established.

Other Ingredients: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, Magnesium stearate (vegetable source), and Silica. Contains lecithin from soy. NeuroImmune 6 59468 10164 6 90 Capsules L20040AVI90.02

Label size: 7 x 2.75in

References 1. Pongratz G and Straub R. Arthritis Res Ther. 2014;16:504. 2. Kasperczyk S, et al. Toxicol Appl Pharmacol. 2014;280(1):36-41. 3. Spindler M, et al. Neuropsychiatr Disease Treatment. 2009;5:597-610. 4. Rochette L, et al. Can J Physiol Pharmacol. 2015;93(12):1021-7. 5. Liu X, et al. Restor Neurol Neurosci. 2013;31(2):109-23.

*These statements have not been evaluated by the Food and Drug Administration. 19 This product is not intended to diagnose, treat, cure or prevent any disease. Best New Calm G Seller Kavinace OS Product Contains a blend of ingredients Comprehensive blend of important for regulating antioxidants shown to improve the onset, duration, glutamate activity, stress- and efficiency of sleep while reduction, metabolic health, and addressing oxidative stress* mitochondrial function*

Item Size Serving size Servings/container Item Size Serving size Servings/container 20004 90 Capsules 2 Capsules 45 20053 60 Capsules 2 Capsules 30

Key Ingredients: Key Ingredients: • N-acetyl-L-cysteine • L-theanine • Zinc • L-theanine • Resveratrol • Selenium • Alpha-lipoic acid • Astaxanthin • Melatonin • Coenzyme Q10 • Magnesium

Suggested Use

Suggested Use Take 2 capsules Supplementat bedtime or as directed by Facts Supplement Facts Take 1-2 capsules three to four times daily or as Serving Size: 2 Capsules directed by your healthcare provider. Do not exceed your healthcare provider.Serving Size:Do not 2 Capsules exceed Servings Per Container: 30 suggested use. suggested use. Servings Per Container: 45 This product has a tamper evident seal under the cap. This product has a tamper evident seal under Amount Per Serving % Daily Value Amount Per Serving % Daily Value Do not use if seal is broken or missing. Store at room the cap. Do not use if seal is broken or missing. temperature, in a dry place. Store at room temperature,Folate (as L-5-methyltetra- in a dry place. 272 mcg DFE 68% Magnesium 25 mg 6% ‡ If you are pregnant or nursing, consult your healthcare If you are pregnanthydrofolate, or nursing, calcium consult salt your) (as magnesium bisglycinate chelate) provider before use. Keep out of reach of children. healthcare providerSelenium before (from use. L-selenomethionine)Keep out of 70 mcg 127% Zinc (as zinc bisglycinate chelate) 15 mg 136% reach of children. Selenium (as selenomethionine) 200 mcg 364% If gastrointestinal upset occurs, consider taking with food. Proprietary Blend 1.1 g † N-acetyl-L-cysteine, Alpha-lipoic acid, L-theanine, and Melatonin 5 mg † Coenzyme Q10. NeuroScience Quality NeuroScience Quality Proprietary Blend 214 mg † Consistent products, consistent Consistent products, consistent † Dailyresults. Value Scan not to learn established. more. L-theanine, Trans-resveratrol (Polygonum results. Scan to learn more. cuspidatum) (root), and Astaxanthin Other ingredients: Vegetable capsule (hypromellose, ® (Haematococcus pluvialis). ™ water), microcrystalline cellulose, magnesium stearate Calm G (vegetable source), silica, and dicalcium phosphate.Kavinace OS † Daily Value not established. ‡ Magnafolate is a registered trademark of Lianyungang Jinkang Pharmaceutical Technology Co., Ltd. Dietary Supplement Dietary Supplement Other ingredients: Vegetable capsule (hypromellose, NeuroImmune NeuroImmune water), organic rice concentrate, microcrystalline cellulose, dicalcium phosphate, citric acid, and glycine. Distributed by: Osceola, WI 54020 +1-888-342-7272 Distributed by: Osceola, WI 54020 6 59468 10114 1 90 CAPSULES www.neuroscienceinc.com L20004CG90.14 +1-888-342-7272 6 59468 10177 6 60 CAPSULES www.neuroscienceinc.com L20053KAVOS60.02 Label size: 7 x 2.75in Label size: 6 x 2.75in

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 20 New Kavinace OS Product Emulsion Comprehensive blend of antioxidants shown to improve the onset, duration, and efficiency of sleep while addressing oxidative stress*

Item Size Serving size Servings/container 20054 8 fl oz 1 Tablespoon 15

Key Ingredients: • L-theanine • Zinc • Resveratrol • Selenium • Astaxanthin • Melatonin • Magnesium

If you are pregnant or nursing, consult Suggested Use: Take 1 tablespoon (15 mL) at bedtime your healthcare provider before use. or as directed by your healthcare provider. Do not exceed suggested use. This product has a tamper evident seal under the cap. Do not use if seal is Supplement Facts broken or missing. Serving Size: 1 Tablespoon (15 mL) Servings Per Container: 15 Keep out of reach of children. Store at room temperature, in a dry place. Amount Per Serving % Daily Value* Calories 84 Distributed by NeuroScience Total Fat 8 g 12% Osceola, WI 54020 • 888-342-7272 Saturated fat 0 g 0% www.neuroscienceinc.com ® Polyunsaturated fat 4 g † Kavinace OS Monounsaturated fat 4 g † Cholesterol 0 mg 0% Contains Tree Nuts (Almonds). Total Carbohydrate 3 g 1% Chocolate Coconut Total Sugars 0 g † ‡ Non-GMO ingredient Protein 1.5 g Flavored Emulsion Vitamin E (as D-alpha tocopherol) 9 IU 30% Magnesium 25 mg 6% (as magnesium bisglycinate chelate) Zinc (as zinc bisglycinate chelate) 15 mg 100% Selenium (as selenomethionine) 200 mcg 286% Melatonin 5 mg †

Proprietary Blend 214 mg † L-theanine, Resveratrol (as trans-resveratrol), and Astaxanthin.

* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established. Ingredients: Sunflower oil‡, Almond butter‡ (100% 6 59468 10174 5 Dietary Supplement almonds), Purified water, Glycerin (vegetable source),

NeuroImmune Natural flavors, Organic cocoa powder, and Potassium 8 fl oz (227g) bicarbonate. L20054KAVOSE8.01

*These statements have not been evaluated by the Food and Drug Administration. 21 This product is not intended to diagnose, treat, cure or prevent any disease. NeuroImmune Ingredient Index

Acetyl-L-carnitine: Derivative of L-carnitine, a compound that facilitates energy production in mitochondria and provides antioxidant protection47-49* Alpha-GPC: Patented choline donor and precursor to acetylcholine50,51 Alpha-lipoic acid: Antioxidant that is able to regenerate endogenous antioxidants and scavenge metal ions and free radicals52* Astaxanthin: A fat-soluble carotenoid with unique cell membrane activity, antioxidant properties, and neuroprotective effects53* Coenzyme Q10: Compound found in nearly every human cell that is essential for mitochondrial function and antioxidant protection56* Folate (as 5-MTHF): Necessary vitamin in the development and regulation of the nervous system, including the synthesis of neurotransmitters7-9* Huperzine A: Slows the breakdown of the neurotransmitter acetylcholine by inhibiting the enzyme acetylcholinesterase13* L-methionine: Essential amino acid precursor to S-adenosyl-L- methionine (SAMe), an important cofactor in the synthesis of the catecholamines14,15* L-theanine: Amino acid that acts as a glutamate receptor antagonist57* Magnesium: Cofactor for multiple mechanisms in the body including the production of serotonin and acting as a GABA agonist58* Melatonin: Antioxidant and hormone important for the regulation of the sleep-wake cycle70* Mixed tocopherols: Fat-soluble blend of vitamin E isoforms that are antioxidants with free radical scavenging properties59* N-acetyl-L-cysteine: Precursor to L-cysteine, which is required for the synthesis of glutathione, an endogenous antioxidant 20,21 Resveratrol (trans-resveratrol): Polyphenol antioxidant that supports blood sugar management61,62* Selenium: Micronutrient that helps to comprise selenoproteins; these proteins are crucial for brain function and for enzymes such as glutathione peroxidase22* Vitamin A: Fat-soluble vitamin important for retinal health, bone growth, and wound healing64* Vitamin D3: Fat-soluble vitamin that plays an important role in bone and immune health65* Vitamin E: Antioxidant that plays a role in neurological function and protection25,26* Vitamin K: Fat-soluble vitamin required for protein biosynthesis and enzymatic processes important for blood coagulation, cell growth, and bone formation66* Zinc: Essential micronutrient cofactor for multiple processes including the antioxidant enzyme superoxide dismutase and for retinal tissue75-76*

References on page 38.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 22 NeuroImmune Product Overview

Avipaxin Calm G

Clinical Anxiousness/Stress • Cognition/Focus • Energy Immune • • Sleep Vision Biomarker**

Acetylcholine    Epinephrine Dopamine Glutamate   

Melatonin Norepinephrine Serotonin Ingredients Acetyl-L-carnitine • Alpha-GPC • Alpha-lipoic acid •

Coenzyme Q10 •

Folate •

Huperzine A • L-theanine •

N-acetyl-L-cysteine •

Selenium • Recommended Dosing Dosage Form Capsules Capsules Available Sizes 90 Capsules 90 Capsules Serving Size 3 Capsules 2 Capsules

Suggested Use (Do not exceed suggested use) 1-3 QD-BID 1-2 TID-QID

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. 23 This product is not intended to diagnose, treat, cure or prevent any disease. NeuroImmune Product Overview

Kavinace OS Kavinace OS Emulsion

Clinical Anxiousness/Stress Cognition/Focus Energy Immune • • Sleep • • Vision Biomarker**

Acetylcholine Epinephrine Dopamine Glutamate     Melatonin       Norepinephrine Serotonin Ingredients 5-HTP Astaxanthin • • Boswellia serrata Huperzine A L-cysteine L-theanine • • Magnesium • • Selenium • • Turmeric Zinc • • Recommended Dosing Dosage Form Capsules Emulsion Available Sizes 60 Capsules 8 fl oz Serving Size 2 Capsules 1 Tablespoon (15 mL)

Suggested Use (Do not exceed suggested use) 2 HS 1 Tbsp (15 mL) HS ** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 24 New Serotonin/GABA Alpha GABA Product Serotonin and its receptors are an integral Ingredients to promote calm part of many physiological functions in the during times of anxiousness nervous, endocrine, and gastrointestinal while supporting a healthy 1 systems. Serotonin is important for regulating response to stress, day or night* mood and sleep-wake function.2 GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep.3-5

Products in this category may be recommended for:

• Anxiousness/Stress Item Size Serving size Servings/container • Mood 20057 90 Capsules 3 Capsules 30

• Sleep Key Ingredients: • L-theanine • Ashwagandha (Withania somnifera) extract • Passionflower (Passiflora incarnata) extract • Lemon balm (Melissa officinalis) root extract • 5-HTP (from Griffonia simplicifolia seed extract) • L-taurinez

Suggested Use Take 2-3 capsules up to two times daily or as directed by Supplement Facts your healthcare provider. Do not exceed suggested use. Serving Size: 3 Capsules Servings Per Container: 30 This product has a tamper evident seal under the cap. Do not use if seal is broken or missing. Store at room Amount Per Serving % Daily Value temperature, in a dry place. Vitamin B6 2 mg 118% This product may be unsafe in pregnancy or nursing, (as pyridoxal 5’-phosphate) consult your healthcare provider before use. Keep out of reach of children. L-theanine 400 mg † Ashwagandha extract 250 mg † (Withania somnifera) (root and leaf‡) NeuroScience Quality Consistent products, consistent Proprietary Blend 620 mg † results. Scan to learn more. Passion flower extract (Passiflora incarnata) (aerial parts), Lemon balm extract (Melissa officinalis) (root), and L-taurine. ™ Alpha GABA † Daily Value not established. Not a significant source of sugar. ‡ SENSORIL® is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478, and is a registered trademark of Natreon, Inc. Dietary Supplement Other ingredients: Vegetable capsule (hypromellose, Serotonin/GABA water), microcrystalline cellulose, organic rice concentrate, and silica. Distributed by: Osceola, WI 54020 +1-888-342-7272 6 59468 10182 0 90 CAPSULES www.neuroscienceinc.com L20057AG90.02

Label size: 7 x 2.75in

References 1. Berger M, et al. Annu Rev Med. 2009;60:355-66. 2. Monti J. Sleep Med Rev. 2011;15(4):269-81. 3. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81. 4. Mohler H. Neuropharmacology. 2012;62(1):42.53. 5. Saper C, et al. Nature. 2004;437(7063):1257-63.

*These statements have not been evaluated by the Food and Drug Administration. 25 This product is not intended to diagnose, treat, cure or prevent any disease. Alpha GABA PM GABA Trex Researched blend of botanicals Chewable tablets containing and 400 mg of L-theanine L-theanine, an amino acid shown shown to induce calming brain to reduce stress* waves and naturally improve sleep during times of stress*

Item Size Serving size Servings/container Item Size Serving size Servings/container 20042 60 Capsules 2 Capsules 30 20025 60 Tablets 2 Tablets 30

Key Ingredients: Key Ingredients: • L-theanine • L-theanine • Melatonin • Valerian (Valeriana officinalis) root extract (Valerenic acids 0.8%) • Lemon balm (Melissa officinalis) leaf extract • 5-HTP (from Griffonia simplicifolia seed extract)

Suggested Use Suggested Use Take 1-2 capsules at bedtime or as directed Chew 1-2 tablets up to three timesSupplement daily or as Facts Supplement Facts by your healthcare provider. Do not exceed directed by your healthcare provider.Serving Do Size: not 2 Capsules Serving Size: 2 Tablets suggested use. exceed suggested use. Servings Per Container: 30 Servings Per Container: 30 This product has a tamper evident seal under This product has a tamper evident seal under Amount Per Serving % Daily Value Amount Per Serving % Daily Value the cap. Do not use if seal is broken or missing. the cap. Do not use if seal is broken or missing. Store at room temperature, in a dry place. Store at room temperature, in L-theaninea dry place. 400 mg † Calories 10 If you are pregnant or nursing, consult your If you are pregnant or nursing, Melatoninconsult your 3 mg † Total Carbohydrate 2 g <1%* healthcare provider before use. Keep out of healthcare provider before use. Keep out of Total Sugars 0 g † Proprietary Blend 530 mg † reach of children. reach of children. Valerian extract (Valeriana officinalis) Xylitol 2 g † (root) (0.8% Valerenic acids), Lemon balm L-theanine 200 mg † extract (Melissa officinalis) (leaf), and NeuroScience5-hydroxytryptophan Quality (from Griffonia NeuroScience Quality Consistent products, consistent * Percent Daily Values are based on a 2,000 Consistent products, consistent simplicifolia seed extract). results. Scan to learn more. calorie diet. results. Scan to learn more. TM † Daily Value not established. ® † Daily Value not established. GABA Trex Not a significant source of added sugars. Alpha GABA PM Other ingredients: Vegetable capsuleGrape Flavored Chewables Dietary Supplement (hypromellose, water), organic rice concentrate, Other ingredients: Stearic acid, citric acid, and silica. Dietary Supplement stevia extract (Stevia rebaudiana) (leaf) Serotonin/GABA (Rebaudioside A), natural grape flavor, and Serotonin/GABA magnesium stearate.

Distributed by: Osceola, WI 54020 Distributed by: Osceola, WI 54020 +1-888-342-7272 +1-888-342-7272 6 59468 10166 0 60 CAPSULES6 59468 10145 www.neuroscienceinc.com5 L20042AGP60.0360 TABLETS www.neuroscienceinc.com L20025GT60.12

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 26 Serene SeroTrex Contains a blend of ingredients Chewable tablets with important for mood and sleep- ingredients important for mood wake function* and reducing stress*

Item Size Serving size Servings/container Item Size Serving size Servings/container 2014 60 Capsules 1 Capsule 30 20026 60 Tablets 2 Tablets 30

Key Ingredients: Key Ingredients: • 5-HTP (from Griffonia simplicifolia seed extract) • 5-HTP (from Griffonia simplicifolia seed extract) • Vitamins B and C • L-theanine

Suggested Use Suggested Use Supplement Facts Take 1 capsule one to two times daily or as Chew 1-2 tablets up Supplementto two times daily or as Facts directed by your healthcare provider. Do not Serving Size: 2 Tablets directed by your healthcare provider. Do not Serving Size: 1 Capsule exceed suggested use. Servings Per Container: 30 exceed suggested use. Servings Per Container: 60 This product has a tamper evident seal under This product has a tamper evident seal under Amount Per Serving % Daily Value the cap. Do not use ifAmount seal is broken Per Serving or missing. % Daily Value the cap. Do not use if seal is broken or missing. Store at room temperature, in a dry place. Calories 10 Store at room temperature, in a dry place. Total Carbohydrate < 1 g <1% If you are pregnant orVitamin nursing, C consult (as ascorbic your acid) 300 mg 333% If you are pregnant or nursing, consult your healthcare provider beforeVitamin use. B6 Keep out of 2.5 mg 147% Total Sugars 0 g † healthcare provider before use. Keep out of reach of children. (as pyridoxal 5’-phosphate) Xylitol 2 g † reach of children. Folate (L-5-methyltetra- 240 mcg DFE 60% L-Theanine 200 mg † NeuroSciencehydrofolate, calcium Quality salt‡) 5-Hydroxytryptophan 60 mg † Consistent products, consistent (from Griffonia simplicifolia Seed Extract) NeuroScience Quality results.Calcium Scan to(as learn calcium more. citrate) 74 mg 6% Consistent products, consistent Percent Daily Values are based on a 2,000 results. Scan to learn more. 5-hydroxytryptophan 100 mg † calorie diet. * This statement has not(from been evaluatedGriffonia by simplicifolia the Food seed extract) SeroTrex † Daily Value not established. and Drug Administration. This product is not intended Orange Flavored Chewables to diagnose, treat, cure† Daily or prevent Value any not disease. established. Other Ingredients: Stearic Acid, Magnesium Stearate, Natural Flavors, Citric Acid, Serene ‡ Ingredients support these pathways Dietary Supplement ‡ Magnafolate is a registered trademark Other ingredients: Vegetable capsule Rebaudioside A (From Stevia Leaf Extract). of Lianyungang Jinkang Pharmaceutical Dietary Supplement (hypromellose, water), magnesium stearate Serotonin/GABA*‡ Technology Co., Ltd. (vegetable source), and microcrystalline cellulose. Serotonin/GABA Distributed by: Osceola, WI 54020 6 2 +1-888-342-7272 59468 10146 60 TABLETS www.neuroscienceinc.com L20026ST60.11 Distributed by: Osceola, WI 54020 +1-888-342-7272 60 CAPSULES www.neuroscienceinc.com L2014SER60.13

Label size: 6 x 2.75in

*These statements have not been evaluated by the Food and Drug Administration. 27 This product is not intended to diagnose, treat, cure or prevent any disease. Best TravaCor Seller TravaGen Contains a blend of ingredients Contains a blend of ingredients important for mood and shown to improve mood and reducing stress* reduce stress* Utilizes L-tryptophan to provide gentler conversion to serotonin compared to 5-HTP*

Item Size Serving size Servings/container Item Size Serving size Servings/container 20014 60 Capsules 20 20056 120 Tablet 3 Tablets 40 3 Capsules 2037 120 Capsules 40

Key Ingredients: Key Ingredients: • L-tryptophan • Taurine • Taurine • L-theanine • L-theanine • 5-HTP (from Griffonia simplicifolia seed extract) • Vitamins B and C • Vitamins B and C

Suggested Use Suggested Use Take 1-3 tablets one to two times daily or as directed Supplement Facts Take 1-3 capsules one to two times daily or by your healthcare provider. Do not exceed suggested use. Supplement Facts Serving Size: 3 Tablets as directed by your healthcare provider. Do not This product has a tamper evident seal under the cap. Serving Size: 3 Capsules Servings Per Container: 40 exceed suggested use. Do not use if seal is broken or missing. Store at room Servings Per Container: 20 temperature, in a dry place. Amount Per Serving % Daily Value This product has a tamper evident seal under Vitamin C (as ascorbic acid) 40 mg 44% If you are pregnant or nursing, consult your healthcare Amount Per Serving % Daily Value the cap. Do not use if seal is broken or missing. provider before use. Keep out of reach of children. Niacin (from L-tryptophan) 25 mg NE 156% Store at room temperature, in a dry place. Vitamin C (as ascorbic acid) 40 mg 44% Vitamin B6 (as pyridoxal 5’-phosphate) 9 mg 529% Vitamin B6 (as pyridoxal 5’-phosphate) 9 mg 529% Folate (as L-5-methyltetrahydrofolate, 360 mcg DFE 90% If you are pregnant or nursing, consult your calcium salt‡) NeuroScience Quality Folate (as L-5-methyltetrahydro- 383 mcg DFE 96% Vitamin B12 (as methylcobalamin) 30 mcg 1250% healthcare provider before use. Keep out of Consistent products, consistent folate, calcium salt‡) reach of children. results. Scan to learn more. Vitamin B12 (as methylcobalamin) 30 mcg 1250% Calcium (from dicalcium phosphate) 75 mg 6% Phosphorus (from dicalcium phosphate) 60 mg 5% Magnesium 50 mg 12% (as magnesium bisglycinate chelate) Zinc (from zinc bisglycinate chelate) 6 mg 55% Zinc (as zinc bisglycinate chelate) 10 mg 91% Selenium (from L-selenomethionine) 7 mcg 13% NeuroScience Quality Consistent products, consistent Selenium (as L-selenomethionine) 70 mcg 127% TM Proprietary Blend 1.95 g † results. Scan to learn more. L-tryptophan, Taurine, and L-theanine. Proprietary Blend TravaGe950 mg † n ‡ L-taurine, L-theanine, and L-5-hydroxytryptophan † Daily Value not established. Magnafolate is a registered trademarkTM of Lianyungang Jinkang Pharmaceutical Technology Co., Ltd. (from seed extract). Griffonia simplicifoliaDietary Supplement Other ingredients: Microcrystalline cellulose, food grade glaze, TravaCor hypromellose, croscarmellose sodium, stearic acid, magnesium † Daily Value not established. stearate (vegetable source), silicon dioxide, and magnesium silicate. ‡ Magnafolate is a registered trademark Serotonin/GABA of Lianyungang Jinkang Pharmaceutical Dietary Supplement Other ingredients: Vegetable capsule (hypromellose, water), Distributed by: Osceola, WI 54020 Technology Co., Ltd. microcrystalline cellulose, organic rice concentrate, citric acid, +1-888-342-7272 6Serotonin/GABA59468 10181 3 magnesium stearate (vegetable source), and120 dicalcium TABLETS phosphate. www.neuroscienceinc.com L20056TG120.01

Distributed by: Osceola, WI 54020 +1-888-342-7272 6 59468 10120 2 60 CAPSULES www.neuroscienceinc.com L20014TC60.12

References on page 38.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 28 Serotonin/GABA Ingredient Index Serotonin/GABA Product Overview

5-HTP (5-hydroxytryptophan): Crosses the blood-brain barrier and is the precursor to serotonin and melatonin1 Ashwagandha: Sensoril is backed by 12 clinical studies and has been Alpha GABA Alpha GABA PM shown to significantly reduce stress and anxiousness83* Calcium: A mineral that is important for synaptic transmission in the Clinical Indication nervous system67* Anxiousness/Stress • • Folate (as 5-MTHF): Necessary vitamin in the development and Mood regulation of the nervous system, including the synthesis of Sleep • neurotransmitters7-9* Biomarker** Lemon Balm: Botanical shown to inhibit the enzyme GABA transaminase in vitro, which may increase levels of GABA in the GABA     brain68* Glutamate       57 L-theanine: Amino acid that acts as a glutamate receptor antagonist * Serotonin  L-tryptophan: Essential amino acid precursor to serotonin and Taurine melatonin. L-tryptophan provides gentler conversion to serotonin compared to 5-hydroxytryptophan (5-HTP) as the rate-limiting step Ingredients in the synthesis of serotonin is the conversion of L-tryptophan to 5-HTP • 5-HTP1,69* Ashwagandha • Magnesium: Mineral found in the body that is important for Calcium neurotransmitter release and energy metabolism37* Folate Melatonin: Hormone important for the regulation of the sleep-wake cycle70* L-theanine • • Passionflower: Botanical shown to bind to the GABA site of GABA-A L-tryptophan receptors that are essential for down-regulating the hypothalamic- Lemon balm • • pituitary-adrenal (HPA) axis84,85* Magnesium Selenium: Micronutrient that helps to comprise selenoproteins; Melatonin • these proteins are crucial for brain function and for enzymes such as glutathione peroxidase22* Passionflower • Taurine: Neuroprotective amino acid that provides antioxidant Selenium protection and demonstrates GABA-A agonist activity43-45* Taurine • Valerian root: Both in vitro and in vivo studies demonstrate valerian Valerian root • 71-74 extracts modulate GABA-A receptors * Vitamin B12 Vitamin B12: This vitamin is essential in the development and function Vitamin B6 • of the nervous system and the formation of neurotransmitters46* Vitamin C Vitamin B6: This vitamin is an essential cofactor in the synthesis of Zinc neurotransmitters23* Vitamin C: This vitamin acts as an essential cofactor in the synthesis of Description neurotransmitters24* Dosage Form Capsules Capsules Zinc: Essential micronutrient that is important for synaptic plasticity Available Sizes 90 Capsules 60 Capsules 27 and is commonly found within neurons in the cerebral cortex * Serving Size 3 Capsules 1-2 Capsules

Suggested Use 2-3 BID 1-2 HS (Do not exceed suggested use)

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. 29 This product is not intended to diagnose, treat, cure or prevent any disease. Serotonin/GABA Product Overview

GABA Trex SeroTrex Serene TravaCor TravaGen (Chewable) (Chewable) Clinical Anxiousness/Stress • • • • Cognition/Focus Mood • • • • Sleep • • • • • Vasomotor Biomarker** GABA Glutamate       Melatonin Serotonin      Taurine      Ingredients 5-HTP • • • Ashwagandha Black cohosh Blueberry fruit extract Calcium • Folate • • • L-theanine • • • • L-tryptophan • Magnesium • Melatonin Sceletium Selenium • • Taurine • • Vitamin B12 • • Vitamin B6 • • • Vitamin C • • • Zinc • • Description Dosage Form Chewable Tablets Capsules Chewable Tablets Capsules Capsules Available Sizes 60 Tablets 60 Capsules 60 Tablets 60 and 120 Capsules 120 Capsules Serving Size 2 Tablets 1 Capsule 2 Tablets 3 Capsules 3 Capsules

Suggested Use 1-2 QD-TID 1 QD-BID 1-2 QD-BID 1-3 QD-BID 1-3 QD-BID (Do not exceed suggested use)

** The number and direction of the arrows reflect the precursor potential for metabolic end products and/or the mechanisms of action of select ingredient relationships as compared to other NeuroScience products. Please refer to the Product Quick Reference Guide for more information.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 30 Pathway Biochemistry Guide

Axon Biochemical Methods of Intervention Serotonin 5-HIAA 1 Reuptake Inhibitors Receptor Agonist/Antagonist block the action of transporters that move Synaptic Vesicle Reuptake Inhibitor neurotransmitters from the synapse back into the presynaptic neuron. Tryptophan Enzyme Modulator 2 Autoreceptor 3 5-HTP 5-HIAA: 5-hydroxyindoleacetic acid 5-HTP: 5-hydroxytryptophan Serotonin MAO: Monoamine oxidase 2 Receptor Agonists 5-HIAA mimic the effects of neurotransmitters on receptor binding sites. 4 MAO Antagonists inhibit the effects. Metabolic Enzymes Synapse

1 Reuptake Transporter (Blocked) 3 Amino acid precursors are the biochemical predecessors to neurotransmitters.

4 Enzyme modulators alter the actions of specific enzymes.

2 Post-synaptic Receptors (Bound)

Dendrite

*These statements have not been evaluated by the Food and Drug Administration. 31 This product is not intended to diagnose, treat, cure or prevent any disease. Acetylcholine Pathway Glutamate/GABA Pathway

L-Carnitine Acetyl-CoA Choline glutaminase

glutamine glutamate synthetase decarboxylase Glutamine Glutamate GABA Vitamin B6 Carnitine Choline glutaminase acetyltransferase acetyltransferase 4-aminobutyrate Vitamin B6 transaminase

Citric Succinate Acid Semialdehyde Cycle succinate semialdehyde Acetyl-L-Carnitine CoA Acetylcholine dehydrogenase

Green = Biomarker Blue = Enzyme Green = Biomarker Blue = Enzyme Orange = Cofactor

Adrenal Pathway Gut-Brain Connection

Hypothalamus Brain

Corticotropin- Cortisol releasing Hormone Dopamine GABA Serotonin

Pituitary Sympathetic Enteric Nervous System Facilitates communication Gland Nervous System

Adrenocorticotropic Hormone GI Function Microbiota

Adrenal Gland Motility Immune response Tight junctions Neurotransmitter synthesis

Cortisol Catecholamines

Blue = Hormone Gray = Parasympathetic Green = Biomarker Purple = Sympathetic Green = Biomarker Red = Immune System Orange= Hypothalamic-Pituitary-Adrenal (HPA) axis

Catecholamine Pathway NeuroImmune Pathway

Rate Limiting Step Brain phenylalanine tyrosine hydroxylase hydroxylase Adrenocorticotropic Phenylalanine Tyrosine L-DOPA Hormone Vitamin B6 aromatic amino acid aromatic amino acid Vitamin B6 Vitamin B6 decarboxylase decarboxylase Cytokines Dopamine Adrenal dopamine Acetylcholine Glands PEA Vitamin C b-hydroxylase

Norepinephrine Free Radicals SAMe phenylethanolamine Cortisol Cortisol N-methyltransferase Catecholamines Epinephrine Immune Cells

Green = Biomarker Blue = Enzyme Orange = Cofactor Blue = Hormone Gray = Parasympathetic Green = Biomarker Purple = Sympathetic Red = Immune System Orange= Hypothalamic-Pituitary-Adrenal (HPA) axis

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 32 Tryptophan Pathway Weight Management

Tryptophan

Rate tryptophan Limiting hydroxylase Step cAMP

5-hydroxytryptophan

aromatic amino acid Vitamin B6 decarboxylase Cortisone Cortisol Adipose Cells Serotonin N-acetylserotonin 11b-HSD1 (Fat tissue) serotonin acetyltransferase

monoamine oxidase hydroxyindole SAMe methyltransferase 5-hydroxindoleacetaldehyde Lipolysis

Green = Biomarker Blue = Enzyme Orange = Cofactor Melatonin

Green = Biomarker

*These statements have not been evaluated by the Food and Drug Administration. 33 This product is not intended to diagnose, treat, cure or prevent any disease. NeuroScience Quality Management System Consistent products, consistent results

Scientific Research We formulate based on published scientific journals and clinical studies that discuss safe and effective ingredients as well as the amount necessary for positive outcomes.

Ingredients We audit our manufacturers to ensure ingredients meet our specifications for purity and strength.

Manufacturers We use FDA-inspected facilities located in the United States that are cGMP (Current Good Manufacturing Practices) compliant.

Finished Product Testing We contract laboratories to independently verify the purity, strength, and composition as well as test for microbiological, heavy metal, and chemical contaminants.

(888) 342-7272 www.neuroscienceinc.com Copyright © 2021 NeuroScience 072121-N1018 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 34 NeuroSelect Technology

NeuroSelect is a NeuroScience healthcare provider-exclusive interactive technology formulated to streamline supplement selection, all without personal health information.

NeuroSelect offers five approaches for NeuroScience product selection

QR Scanner Pathway Start with Sleep Clinical Indications Build Your Own

 NeuroSelect App  NeuroSelect App  NeuroSelect App  NeuroSelect App  NeuroSelect App  NeuroScience website  NeuroScience website  NeuroScience website  NeuroScience website

Anxiousness/ QR Scanner Stress

Adrenal Cognition/ Pathway Focus SAMPLE QR CODE Start with Sleep Gut

Clinical Indications Energy Mood

Build Your Own Weight Management

Sleep Immune

Scan code on Select Target sleeplessness Select Create your own neurotransmitter pathway(s) at a source symptom(s) Product Information report Request (PIR)

Also available on our website www.neuroscienceinc.com

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35 How it works

2

1 3 Select Download Login using the same your approach the free app from username and password Google Play or the as our website App Store QR Scanner

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Start with Sleep

Clinical Indications

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6 Access 4 all reports (PIRs) at neuroscienceinc.com with login Follow 5 prompts Instantly view for product selection report (PIR) on a mobile device or computer

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products

Selected products based on the criteria provided

Pathways GABA Dopamine Dopamine Glutamate Epinephrine Epinephrine Serotonin Histamine Norepinephrine Pathway Taurine Norepinephrine Cortisol

Serving Size

Suggested Use*** Take 1-3 capsules one to two Take 1-3 capsules one to two Take 1-2 capsules one to two times daily or as directed by times daily or as directed by times daily or as directed by Serving Size and Suggested Use your healthcare provider your healthcare provider your healthcare provider

Additional Contains a blend of ingredients Contains non-glandular Contains ingredients important Additional Information Information shown to improve mood and ingredients important for for the synthesis of dopamine, a reduce stress* adrenal health and reducing catecholamine important for stress-induced fatigue* positive affect, mood, cognition, Product Alternative: SeroTrex and craving control* chewable tablets Product Alternative: TyroCelle or Calm PRT

Notes TravaCor AdreCor Balance D

Taurine L-methionine N-acetyl-L-cysteine Neuroprotective amino acid that provides Precursor to S-adenosyl-L-methionine Precursor to L-cysteine.1 L-cysteine is Key Ingredients 1 antioxidant protection and demonstrates (SAMe). SAMe is directly involved in required for the synthesis of glutathione, an GABA-A agonist activity.1-3* GABA is the methylation processes including endogenous antioxidant.2 primary inhibitory neurotransmitter in the catecholamine synthesis.2 Key Ingredients brain important for calm and sleep.4-6 L-tyrosine N-acetyl-L-tyrosine L-theanine Precursor to catecholamines including L-tyrosine is a precursor to catecholamines Amino acid that acts as a glutamate receptor dopamine, norepinephrine, and epinephrine. including dopamine, norepinephrine, and antagonist.7* Glutamatergic signaling epinephrine.3 ***Do not exceed suggested use underlies mechanisms related to Rhodiola rosea root extract (5% 8 rosavins) Mucuna cochinchinensis seed extract *These statements have not beeann xeivoaulusanteds sb ay ntdh es tFroeosds a.n dIn D aru ragn Addomiinziesdtr,ation. This product is not intended to diagnose, treat, cure or prevent any disease. double-blind, placebo-controlled study, L- Adaptogen that has been shown to reduce (99% L-DOPA) stress-induced effects.3,4* In a randomized, Natural source of L-DOPA.4 L-DOPA crosses Product information was requested bthy eaa hneianlteh cwaares p srohvoidwern atnod s isig nnoitfi icntaenntdleyd r teod duiacgenose, treat, cure or prevent any diseases. References provided are not specific to an individual and do not change based on 9 the blood-brain barrier and is the direct the product information request. Prosdturcets ss.el*ected are based on specific requests or information dporeusbelnete-db lininddic,a ptinlag ctheeb ogo-acl oisn toro sleleledct s intugrdeyd,ients with mechanisms that scientifically promote biochemical 5 pathway(s) or clinical indication(s) to theoretically shift toward the statistical median or have reseRarhcho dinidoilcaa trinogs ae as ywmapsto smh ocowunld tboe sciogrnreifilatceadn ttol yan element pinr ea cpuarthswoar yt.o dopamine. 5-HTP (from Griffonia simplicifolia improve mental fatigue and general well- seed extract) being under stress.4* 5-hydroxytryptophan (5-HTP) crosses the blood-brain barrier and is a precursor to Green tea leaf extract (Camellia Copyright © 2020 NeuroScienceserotonin and melatonin.10* Serotonin is 092820-N1023sinensis) (65% EGCG) (888) 342-7272 www.neuroscienceinc.com important for regulating mood and sleep- Epigallocatechin gallate (EGCG) is a wake function.11 In a randomized, double- polyphenol in green tea that provides blind study, 5-HTP was shown to antioxidant protection by its ability to 5 significantly improve mood.12* scavenge free radicals and metal ions. * *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References TravaCor AdreCor Balance D

1. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27. 1. Duncan T, et al. Mol Nutr Food Res. 2013;57(4):628- 1. Rushworth G and Megson I. Pharmacol Ther. 2. Shimada K, et al. Adv Exp Med Biol. 2015;803:581- 36. 2014;141(2):150-9. 96. 2. Mischoulon D and Fava M. Am J Clin Nutr. 2. Schmitt B, et al. Redox Biol. 2015;6:198-205. 3. Kletke O, et al. PLoS One. 2013;8(4):e61733. 2002;76(5):1158S-61S. 3. Ng J, et al. Nat Rev Neurol. 2015;11:567-84. 4. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75- 3. Chiang H, et al. J Food Drug Anal. 2015;23(3):359-69. 4. Tuleun C, et al. Livestock Research for Rural 81. 4. Spasov A, et al. Phytomedicine. 2000;7(2):85-9. Development. 2008;20(10). 36 5. Mohler H. Neuropharmacology. 2012;62(1):42-53. 5. Legeay S, et al. Nutrients. 2015;7(7):5443-68. 5. Pardridge W. NeuroRx. 2005;2(1):3-14. 6. Saper C, et al. Nature. 2005;437(7063):1257-63. Magnafolate is a registered trademark of Lianyungang Magnafolate is a registered trademark of Lianyungang 7. Kakuda T, et al. Biosci Biotechnol Biochem. Jinkang Pharmaceutical Technology Co., Ltd. Jinkang Pharmaceutical Technology Co., Ltd. 2002;66(12):2683-2686. 8. Bermudo-Soriano C, et al. Pharmacol Biochem Behav. 2012;100(4):752-74. 9. Kimura K, et al. Biol Psychol. 2007; 74(1):39-45. 10. Shaw K, et al. Cochrane Database Syst Rev. 2002; (1):CD003198. 11. Monti J. Sleep Med Rev. 2011;15(4):269-81. 12. Jangid P, et al. Asian J Psychiatr. 2013;6(1):29-34.

Magnafolate is a registered trademark of Lianyungang Jinkang Pharmaceutical Technology Co., Ltd.

***Do not exceed suggested use

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Product information was requested by a healthcare provider and is not intended to diagnose, treat, cure or prevent any diseases. References provided are not specific to an individual and do not change based on the product information request. Products selected are based on specific requests or information presented indicating the goal is to select ingredients with mechanisms that scientifically promote biochemical pathway(s) or clinical indication(s) to theoretically shift toward the statistical median or have research indicating a symptom could be correlated to an element in a pathway. Product Ordering

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37 NeuroScience welcomes an opportunity to speak with you. References Please feel free to contact us. 1. Shaw K, et al. Cochrane Database Syst Rev. 2002;(1):CD003198. 2. Kamkaew N, et al. Phytother Res. 2013;27(1):135-8. 3. Liu X, et al. Restor Neurol Neurosci. 2013;31(2):109-23. 4. Rastogi M, et al. Biogerontology. 2012;13(2):183-95. Phone 1-888-342-7272 5. Sheikh N, et al. J Ethnopharmacol. 2007;111(3):671-6. Fax 1-715-294-3921 6. Cefalu WT and Hu FB. Diabetes Care. 2004;27(11):2741-51. 7. Antoniades C, et al. Circulation. 2006;114(11):1193-201. Online www.neuroscienceinc.com/contact/ 8. Mattson M and Shea T. Trends Neurosci. 2003;26(3):137-46. 9. Stahl S. J Clin Psychiatry. 2008;69(9):1352-3. 10. Godard M, et al. Obes Res. 2005;13(8):1335-43. 11. Jeukendrup A and Randell R. Obes Rev. 2011;12(10):841-51. Address 373 280th Street, Osceola, WI 54020 12. Lee M, et al. Phytother Res. 2009;23(8):1088-91. 13. Tun M and Herzon S. J Exp Pharmacol. 2012;4:113-23. 14. Duncan T, et al. Mol Nutr Food Res. 2013;57(4):628-36. 15. Mischoulon D and Fava M. Am J Clin Nutr. 2002;76(5):1158S-61S. Email [email protected] 16. Ng J, et al. Nat Rev Neurol. 2015;11:567-84. Web www.neuroscienceinc.com 17. Chen P, et al. J Neurochem. 2015;134:601-610. 18. Tuleun C, et al. Livestock Research for Rural Development. 2008;20(10). 19. Pardridge W. NeuroRx. 2005:2(1):3-14. 20. Rushworth G and Megson I. Pharmacol Ther. 2014;141(2):150-9. 21. Schmitt B, et al. Redox Biol. 2015;6:198-205. 22. Rayman MP. Lancet. 2012;379:1256-69. Follow us 23. Martin D. Cell Mol Neurobiol. 1987;7(3):237-53. 24. May J, et al. Brain Res Bull. 2013;90:35-42. 25. Lobo V, et al. Pharmacogn Rev. 2010;4(8):118-126. 26. Nooyens A, et al. Brit J Nutr. 2015;113:1410-1417. 27. Frederickson CJ, et al. Nat Rev Neurosci. 2005;6:449-462. 28. Patel H, et al. Arabian Journal of Chemistry. 2015. 29. Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15. 30. Kawai N, et al. Amino Acids. 2012;42(6):2129-37. Join our list 31. 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