DOCSLIB.ORG

Hussein Mostafa Mohammed El-Zaher

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Hussein Mostafa Mohammed El-Zaher Benha University Faculty of Agriculture Animal Production Dept. EFFECT OF PHOTOPERIOD ON OVARIAN ENDOCRINE FUNCTION IN RABBITS By HUSSEIN MOSTAFA MOHAMMED EL-ZAHER B.Sc. in Agric. Sci. (Animal Production) 1999, Faculty of Agriculture, Zagazig University (Benha Branch) THESIS Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN ANIMAL PHYSIOLOGY Department of Animal Production Faculty of Agriculture Benha University Egypt 2011 SUPERVISION COMMITTEE EFFECT OF PHOTOPERIOD ON OVARIAN ENDOCRINE FUNCTION IN RABBITS By HUSSEIN MOSTAFA MOHAMMED EL-ZAHER B. Sc. Agric. Sci, (Animal Production) 1999, Faculty of Agriculture, Zagazig University (Benha Branch) THESIS Submitted in partial fulfillment of the Requirement for the degree of MASTER OF SCIENCE IN )ANIMAL PHYSIOLOGY( Under supervision of: ** Prof. Dr. Mohammed, S. Gado …………………………………. Professor of Animal Physiology, Animal Production Dept. Faculty of Agriculture, Benha University. ** Prof. Dr. Gaafar, M. El-Gendi …..……………………………... Professor of Poultry Management, Animal Production Dept. Faculty of Agriculture, Benha University. ** Dr. Magdy Hassan, G. Ishak ….…………………………........ Assoc.Professor of Physiology and Head of Endocrinology Research Unit, Radiobiological Applied Dept. Nuclear Research Center, Atomic Energy Authority. APPROVAL COMMITTE EFFECT OF PHOTOPERIOD ON OVARIAN ENDOCRINE FUNCTION IN RABBITS By HUSSEIN MOSTAFA MOHAMMED EL-ZAHER B. Sc. Agric. Sci. (Animal Production) 1999, Faculty of Agriculture, Zagazig University (Benha Branch) THESIS Submitted in partial fulfillment of the Requirements for the degree of MASTER OF SCIENCE IN ANIMAL PHYSIOLOGY This thesis for M.Sc. degree has been approved by: ** Prof. Dr. Mohammed, S. Gado ………………………………. Professor of Animal Physiology, Animal Production Dept. Faculty of Agriculture, Benha University. ** Prof. Dr. Medhat, H. Khalil ….…………………………… Professor of Animal Physiology, Animal Production Dept. Faculty of Agriculture, Al- Azhar University. ** Prof. Dr. Ahmed, A. Radwn ...………………………..... Professor of Poultry Physiology, Animal Production Dept. Faculty of Agriculture, Benha University. ** Prof. Dr. Gaafar, M. El-Gendi .…………………………... Professor of Poultry Management, Animal Production Dept. Faculty of Agriculture, Benha University. ** Dr. Magdy Hassan G. Ishak …………………………....... Assoc. Professor of Physiology, Head of Endocrinology Research Unit, Radiobiological Applied Dept. Nuclear Research Center, Atomic Energy Authority. Date of Examination: / / 2011. 1 ACKNOWLEDGMENT I am greatly indebted to: Professor Mohamed safwat Abd El-Magied Gado, supervisor of this work and Professor of Animal physiology, Department of Animal Production, Faculty of Agriculture, Benha University for planning the research work, close supervision and valuable comments, without his initiative and constructive advice, this study would not have been possible. I am also thankful for his patient and kindness. Professor Gaafar Mohamed Ibrahim El-Gendi, Professor of Poultry Production , Faculty of Agriculture, Benha University for his helpful and effective support during the lifespan of this work. Dr. Magdy Hassan Gamal Ishak, Assoc. Professor of Physiology and Head of Endocrinology Research Unit, Applied Radiobiological department, Nuclear Research Center, Atomic Energy Authority, Inshas Egypt and Professor Ibrahim Mohamed El-Banna Professor of Physiology, Endocrinology Research Unit, Applied Radiobiological department, Nuclear Research Center, Atomic Energy Authority, Inshas Egypt for suggesting the problem, designing the experiment work, testing the hypothesis, offering all facilities, encouragement, valuable guidance and criticism. TABLE OF CONTENTS Page 1- INTRODUCTION.................................................................................. 1 2- REVIEW OF LITERATURE............................................................... 7 2.1. Overview of reproduction and productivity of female rabbits 7 emphasizing photoperiod effect...................................................... 2.2. Natural Endocrine control of reproduction..................................... 11 2.3. Ovulation induction......................................................................... 17 2.4. Hormonal mechanism during ovulation.......................................... 18 2.5. Neuroendocrine control of ovulation.............................................. 20 2.6. Mechanism of Ovarian Follicle Rupture......................................... 25 2.7. Biosynthesis and biological effect of Melatonin on reproduction............................. 27 2.8. Effect of Photoperiod on Melatonin Biosynthesis.......................... 33 2.9. Pineal gland activity and the role of melatonin in transducing photoperiodic Information............................................................. 38 2.9.1. Pineal gland activity............................................................. 38 2.9.2. Critical features of Melatonin secretion as affected by rhythm..................... 40 2.10. Role of Melatonin in reproduction................................................ 46 2.11. Effect of serotonin in reproduction............................................... 48 2.12. Effect of human chorionic gonadotropin (HCG) on the 50 mechanism of ovulation.............................................................. 2.13. Effect of sexual steroidal hormones on oogenesis and ovulation……...... 52 2.14. Effect of prolactin (PRL) on oogenesis and ovulation.................. 57 2.15. Bromocriptine: an ergoline derivative acts as dopamine agonist used in Hyperprolactinaemia...................................................... 61 2.16. Prostaglandin (PG) function on uterine contraction and ovulation……...... 63 2.17. Effect of indomethacin on the prostaglandin biosynthesis........... 66 3. MATERIALS AND METHODS........................................................... 73 3.1. Grouping of animals and experimental design................................. 73 I 3.2. Hormonal modulators applied.......................................................... 77 3.2.1. Indomethacin....................................................................... 77 3.2.2. Bromocriptine (parlodel cycloset)...................................... 78 3.2.3. Melatonin…………………………………………………. 79 3.2.4. Serotonin………………………………………………..... 80 3.3. Injected materials............................................................................. 81 3.4. Parameters estimated and data collection......................................... 82 3.4.1. Blood samples collection..................................................... 82 3.4.2. Chemicals and reagents used in chemical analysis.............. 82 3.4.3. Progesterone (P4) radioimmunoassay................................. 83 3.4.3.1. Assay buffers....................................................... 84 3.4.3.2. Assay procedure.................................................. 85 4. RESULTS AND DISCUSSIONS.......................................................... 88 4.1. First experiment.............................................................................. 88 4.1.1. Serum progesterone level in untreated does subjected to different lighting regimes applied...................................... 89 4.1.2. Effect of HCG....................................................................... 90 4.1.3. Effect of Melatonin............................................................... 97 4.1.4. Effect of serotonin................................................................. 103 4.1.5. Effect of bromocriptine......................................................... 109 4.1.6. Effect of indomethacin.......................................................... 116 4.2. Second experiment.......................................................................... 122 4.2.1. Serum progesterone level in does treated with HCG............ 122 4.2.2. Serum progesterone level in does treated with HCG in combination with melatonin.............................................. 124 4.2.3. Serum progesterone level in does treated with HCG in combination with serotonin................................................ 130 4.2.4. Serum progesterone level in does treated with HCG in combination with bromocriptine........................................ 136 4.2.5 Serum progesterone level in does treated with HCG in combination with indomethacin......................................... 143 5. CONCLUSION………………………………………………………... 149 6. SUMMARY............................................................................................. 150 II 7. REFERENCES....................................................................................... 160 8. APPENDIX TABLES............................................................................. 212 9. ARABIC SUMMARY............................................................................ ---- III LIST OF TABLES Table Title Page 1.a Design of the first experiment and number of animals 75 subjected to different photoperiods. Design of the second experiment and number of animals 1.b subjected to different photoperiods. 76 Protocol of injected materials during the course of 2 81 experiments Progesterone serum levels (ng/ml) x ±SE in response to injection of HCG vs saline at short darkness photoperiod (8D/16L), equal dark 3 93 and light photoperiod (12D/12L) and long darkness photoperiod (16D/8L). Analysis of variance of data (cumulative area under curve in units) 4 94 collected after injection of HCG vs saline under different photoperiods. Progesterone
Load more

Recommended publications
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
    US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig.
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins
    Article Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins Márton Enesei 1,2,László Takács 2, Enik˝oTormási 3, Adrienn Tóthné Rácz 3, Zita Róka 3, Mihály Kádár 3 and Zsuzsanna Kardos 2,* 1 Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, M˝uegyetemrakpart 3, 1111 Budapest, Hungary; [email protected] 2 CHINOIN, a member of Sanofi Group, PG Development, Tó utca 1-5, 1045 Budapest, Hungary; laszlo.takacs@sanofi.com 3 CHINOIN, a member of Sanofi Group, PG Analytics, Tó utca 1-5, 1045 Budapest, Hungary; robertne.tormasi@sanofi.com (E.T.); adrienn.tothneracz@sanofi.com (A.T.R.); zita.roka@sanofi.com (Z.R.); mihaly.kadar@sanofi.com (M.K.) * Correspondence: zsuzsanna.kardos@sanofi.com Received: 15 June 2020; Accepted: 10 August 2020; Published: 18 August 2020 Abstract: Four enantiomeric forms of natural prostaglandins, ent-PGF α (( )-1), ent-PGE ((+)-2) 2 − 2 ent-PGF α (( )-3), and ent-PGE ((+)-4) have been synthetized in gram scale by Corey synthesis used 1 − 1 in the prostaglandin plants of CHINOIN, Budapest. Chiral HPLC methods have been developed to separate the enantiomeric pairs. Enantiomers of natural prostaglandins can be used as analytical standards to verify the enantiopurity of synthetic prostaglandins, or as biomarkers to study oxidation processes in vivo. Keywords: preparation; ent-PGF2α; ent-PGF1α; ent-PGE2; ent-PGE1; chiral HPLC; enantiomeric separation; mirror images; enantiopurity 1. Introduction Interest in the field of prostaglandins has been steadily growing since the basic work of Bergström Samuelsson, and Vane [1–3]. Their discoveries revealed the structure, the enzyme-controlled biochemical synthesis from arachidonic acid, and the main physiological effects of prostaglandins as well as their related substances.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Information to Users
    INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely afreet reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. University Microfilms International A Bell & Howell Information Company 300 North Zeeb Road, Ann Arbor. Ml 48106-1346 USA 313/761-4700 800/521-0600 Order Number 9211114 Telemetric evaluation of uterine electromyographic activity and body temperature in the horse mare Cross, David Thomas, Ph.D. The Ohio State University, 1991 Copyright ©1991by Cross, David Thomas.
    [Show full text]
  • Baars, H., Classen, M. J., & Aggarwal, V. K. (2017). Synthesis Of
    Baars, H., Classen, M. J., & Aggarwal, V. K. (2017). Synthesis of Alfaprostol and PGF2α through 1,4-Addition of an Alkyne to an Enal Intermediate as the Key Step. Organic Letters, 19(21), 6008-6011. https://doi.org/10.1021/acs.orglett.7b03057 Peer reviewed version Link to published version (if available): 10.1021/acs.orglett.7b03057 Link to publication record in Explore Bristol Research PDF-document This is the author accepted manuscript (AAM). The final published version (version of record) is available online via ACS Publications at http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b03057. Please refer to any applicable terms of use of the publisher. University of Bristol - Explore Bristol Research General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/red/research-policy/pure/user-guides/ebr-terms/ Synthesis of Alfaprostol and PGF2 Through 1,4-Addition of an Alkyne to an Enal Intermediate as the Key Step Hannah Baars‡, Moritz J. Classen‡, Varinder K. Aggarwal* School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, U.K. Supporting Information Placeholder ABSTRACT: The veterinary drug Alfaprostol and prostaglandin PGF2 have been synthesized in just 9 steps. The strategy involved the conjugate addition of an alkyne to a bicyclic enal, available in three steps by a proline-catalyzed aldol reaction of succinaldehyde. In the case of Alfaprostol, this resulted in the shortest synthesis reported to date. For PGF2 this approach improved our previous route by making the 1,4-addition and ozonolysis more operationally simple.
    [Show full text]
  • $Νͩgȫsȫodⱥ 1Sεdȳfȝ̢oht
    E-435 $SSOLHG5HSURGXFWLYH6WUDWHJLHVLQ%HHI&DWWOH $ΝͩGȪSȪODȺ1SΕDȲFȜ̢OHT 1RYHPEHU 0HPRULDO6WXGHQW&HQWHU 7H[DV$ 08QLYHUVLW\ &ROOHJH6WDWLRQ7H[DV 1SɚȪͩUFȠCZ 1RUWK&HQWUDO5HJLRQ%RYLQH 5HSURGXFWLRQ7DVN)RUFH 7H[DV$JULFXOWXUDO([SHULPHQW6WDWLRQ 7H[DV&RRSHUDWLYH([WHQVLRQ 7H[DV$ 0'HSDUWPHQWRI$QLPDO6FLHQFH 7H[DV$ 0&ROOHJHRI9HWHULQDU\0HGLFLQH DQG%LRPHGLFDO6FLHQFHV 2IILFHRI9HWHULQDU\&RQWLQXLQJ(GXFDWLRQ SPONSORS Gold Level Silver Level ABS Global ALLTECH www.abs.com www.alltech.com Aloka Bovine Elite www. Aloka.com www.bovine-elite.com COBA/Select Sires Classic Medical www.selectsires.com www.classicmedical.com IVX Animal Health HeatWatch www.dvmpharmaceuticals.com www.cowchips.net Pfizer Animal Health Intervet www.pfizerah.com www.intervet.com Merial Universal Cooperative/Estrus http://us.merial.com Alert; www.estrusalert.com NCBA www.ncba.com PROCEEDINGS APPLIED REPRODUCTIVE STRATEGIES IN BEEF CATTLE November 12 and 13, 2005 Memorial Student Center, Texas A&M University College Station Edited by G.L. Williams and D.W. Forrest Program Coordinators: Dr. Gary Williams, Texas Agricultural Experiment Station, Beeville Dr. David Forrest, Texas A&M University, College Station Dr. David Patterson, University of Missouri, Columbia Presented By: North Central Reproductive Task Force and The Texas A&M University System Including: Texas Agricultural Experiment Station Texas Cooperative Extension Texas A&M University Department of Animal Science Texas A&M University College of Veterinary Medicine and Biomedical Sciences Office of Veterinary Continuing Education CONTINUING EDUCATION The Texas Board of Veterinary Examiners has approved this program for 15 continuing education units The American Registry of Professional Animal Scientists has approved this program for 13 continuing education units ADDITIONAL COPIES Additional copies of the proceedings can be purchased for $25.00 by contacting the Department of Animal Science, 2471 TAMU, College Station, TX 77843-2471; Tel.
    [Show full text]
  • Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: the Rabbit Model
    animals Review Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model Massimo Zerani , Angela Polisca *, Cristiano Boiti and Margherita Maranesi Dipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, 06126 Perugia, Italy; [email protected] (M.Z.); [email protected] (C.B.); [email protected] (M.M.) * Correspondence: [email protected] Simple Summary: Corpora lutea (CL) are temporary endocrine structures that secrete progesterone, which is essential for maintaining a healthy pregnancy. A variety of regulatory factors come into play in modulating the functional lifespan of CL, with luteotropic and luteolytic effects. Many aspects of luteal phase physiology have been clarified, yet many others have not yet been determined, including the molecular and/or cellular mechanisms that maintain the CL from the beginning of luteolysis during early CL development. This paper summarizes our current knowledge of the endocrine and cellular mechanisms involved in multifactorial CL lifespan regulation, using the pseudopregnant rabbit model. Abstract: Our research group studied the biological regulatory mechanisms of the corpora lutea (CL), paying particular attention to the pseudopregnant rabbit model, which has the advantage that the relative luteal age following ovulation is induced by the gonadotrophin-releasing hormone (GnRH). CL are temporary endocrine structures that secrete progesterone, which is essential for maintaining a healthy pregnancy. It is now clear that, besides the classical regulatory mechanism exerted by Citation: Zerani, M.; Polisca, A.; prostaglandin E2 (luteotropic) and prostaglandin F2α (luteolytic), a considerable number of other Boiti, C.; Maranesi, M. Current effectors assist in the regulation of CL. The aim of this paper is to summarize our current knowledge Knowledge on the Multifactorial of the multifactorial mechanisms regulating CL lifespan in rabbits.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • Temporal Expression of Progesterone and Proteins Associated with Prostaglandin F2alpha-Induced Luteolysis in the Sheep
    University of New Hampshire University of New Hampshire Scholars' Repository Master's Theses and Capstones Student Scholarship Spring 2009 Temporal expression of progesterone and proteins associated with prostaglandin F2alpha-induced luteolysis in the sheep Darren E. Ferguson University of New Hampshire, Durham Follow this and additional works at: https://scholars.unh.edu/thesis Recommended Citation Ferguson, Darren E., "Temporal expression of progesterone and proteins associated with prostaglandin F2alpha-induced luteolysis in the sheep" (2009). Master's Theses and Capstones. 446. https://scholars.unh.edu/thesis/446 This Thesis is brought to you for free and open access by the Student Scholarship at University of New Hampshire Scholars' Repository. It has been accepted for inclusion in Master's Theses and Capstones by an authorized administrator of University of New Hampshire Scholars' Repository. For more information, please contact [email protected]. TEMPORAL EXPRESSION OF PROGESTERONE AND PROTEINS ASSOCIATED WITH PROSTAGLANDIN F2Q INDUCED LUTEOLYSIS IN THE SHEEP BY Darren E. Ferguson B. A. University of New Hampshire, 2006 THESIS Submitted to the University of New Hampshire in Partial Fulfillment of the Requirements for the Degree of Master of Science in Animal Science May, 2009 UMI Number: 1466931 INFORMATION TO USERS The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleed-through, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr
    US008158152B2 (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr. 17, 2012 (54) LYOPHILIZATION PROCESS AND 6,884,422 B1 4/2005 Liu et al. PRODUCTS OBTANED THEREBY 6,900, 184 B2 5/2005 Cohen et al. 2002fOO 10357 A1 1/2002 Stogniew etal. 2002/009 1270 A1 7, 2002 Wu et al. (75) Inventor: Nageswara R. Palepu. Mill Creek, WA 2002/0143038 A1 10/2002 Bandyopadhyay et al. (US) 2002fO155097 A1 10, 2002 Te 2003, OO68416 A1 4/2003 Burgess et al. 2003/0077321 A1 4/2003 Kiel et al. (73) Assignee: SciDose LLC, Amherst, MA (US) 2003, OO82236 A1 5/2003 Mathiowitz et al. 2003/0096378 A1 5/2003 Qiu et al. (*) Notice: Subject to any disclaimer, the term of this 2003/OO96797 A1 5/2003 Stogniew et al. patent is extended or adjusted under 35 2003.01.1331.6 A1 6/2003 Kaisheva et al. U.S.C. 154(b) by 1560 days. 2003. O191157 A1 10, 2003 Doen 2003/0202978 A1 10, 2003 Maa et al. 2003/0211042 A1 11/2003 Evans (21) Appl. No.: 11/282,507 2003/0229027 A1 12/2003 Eissens et al. 2004.0005351 A1 1/2004 Kwon (22) Filed: Nov. 18, 2005 2004/0042971 A1 3/2004 Truong-Le et al. 2004/0042972 A1 3/2004 Truong-Le et al. (65) Prior Publication Data 2004.0043042 A1 3/2004 Johnson et al. 2004/OO57927 A1 3/2004 Warne et al. US 2007/O116729 A1 May 24, 2007 2004, OO63792 A1 4/2004 Khera et al.
    [Show full text]
  • Wo 2008/127291 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 23 October 2008 (23.10.2008) WO 2008/127291 A2 (51) International Patent Classification: Jeffrey, J. [US/US]; 106 Glenview Drive, Los Alamos, GOlN 33/53 (2006.01) GOlN 33/68 (2006.01) NM 87544 (US). HARRIS, Michael, N. [US/US]; 295 GOlN 21/76 (2006.01) GOlN 23/223 (2006.01) Kilby Avenue, Los Alamos, NM 87544 (US). BURRELL, Anthony, K. [NZ/US]; 2431 Canyon Glen, Los Alamos, (21) International Application Number: NM 87544 (US). PCT/US2007/021888 (74) Agents: COTTRELL, Bruce, H. et al.; Los Alamos (22) International Filing Date: 10 October 2007 (10.10.2007) National Laboratory, LGTP, MS A187, Los Alamos, NM 87545 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY,BZ, CA, CH, (30) Priority Data: CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, 60/850,594 10 October 2006 (10.10.2006) US ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (71) Applicants (for all designated States except US): LOS LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, ALAMOS NATIONAL SECURITY,LLC [US/US]; Los MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, Alamos National Laboratory, Lc/ip, Ms A187, Los Alamos, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, NM 87545 (US).
    [Show full text]