DOCSLIB.ORG

Vol. April 2019

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Vol. April 2019 (Official Publication of Delhi Psychiatric Society) Vol. 22 No. 1 April, 2019 Delhi Hon. Editor M.S. Bhatia Psychiatric Society Assoc. Editor Shruti Srivastava www.delhipsychiatricsociety.com Journal Committee Aparna Goyal Ankit Saxena Executive Council (2018-2019) N.C. Priyadarshini Editorial Advisory Board A.Q. Siddiqui Office Bearers Ajay Kohli Ajit Avasthi President : Deepak Raheja Ashwani Kumar B.S. Chavan Vice President : Vishal Chhabra E. Mohan Das Indira Sharma General Secretary : Pankaj Kumar M.L. Agarwal Maqbool Dar Patron : N.K. Bohra Mushaq A. Margoob N.K. Bohra Neena Bohra Joint Secretary : Manushree Gupta R.C. Jiloha R.K. Gaur Treasurer : Shruti Srivastava R.K. Solanki Rajesh Nagpal Hon. Editor : M.S. Bhatia Rajesh Rastogi Rajiv Gupta Immediate Past President : Rajesh Goyal Rakesh K. Chadda Roy Kallivayalil S.A. Azmi S.C. Malik S.C. Tiwari Executive Council Members S.K. Khandelwal Smita Deshpande Sunil Mittal Manish S. Kansal T.B. Singh T.P. Jindal T.S.S. Rao Deepak Gupta Tushar Jagawat Editorial Committee: Dinesh Kumar Kataria S.A. Azmi Rajesh Sagar Ajit Sidana Ramesh Chandra Nikhil Raheja Anubhav Rathi Rashmita Saha Anurag Jhanjee Ravi Gupta Shobhana Mittal Dinesh Kataria Rupesh Chaudhary Gaurav Rajendra S.K. Verma Jaswinder Kaur Sandeep Choudhary Editorial Office : Jyoti Prakash Savita Jagawat K.K. Verma Shahzadi Malhotra Department of Psychiatry, Lalit Batra Shalini Malhotra University College of Medical Sciences Maryam Safara Sonali Jhanjee and Guru Teg Bahadur Hospital, N.K. Aggarwal Sujata Sethi Dilshad Garden, Delhi-110095 Nimisha Doval Uday K. Sinha Tel.: 22586262 Extn. 2127 Fax : 0091-11-22590495 Nirmaljit Kaur Vibha Sharma E-mail : [email protected] Pankaj Kumar Vikas Gaur : [email protected] Priyanka Gautam Vishal Chabbra Delhi Psychiatry Journal is Published by Dr. Copyright © The Association of Delhi Psychiatric Society of Delhi. M.S. Bhatia on behalf of Delhi Psychiatric Society (Regd.), University College of Medical The views expressed by authors in publications of Delhi Psychiatry Sciences & G.T.B. Hospital, Dilshad Garden, Delhi- Journal are their own, Editor and Editorial Board do not hold any 110095 (India). Layout Designing and Printing by AAR Computers, 5-C, Pocket B-7, Mayur responsibility for their views. The Publishers are not responsible Vihar Phase-III, Delhi-110096. Correspondence for any error or omission of fact. to: D-1, Naraina Vihar, New Delhi-110028 (India). Delhi Psychiatry Journal 2019; 22:(2) © Delhi Psychiatric Society APRIL 2019 DELHI PSYCHIATRY JOURNAL Vol. 22 No. 1 Contents Editorial Parental Handling Measures Among Physically 57 Psychoeconomics – The Upcoming Role of 5 Challenged Children and Normal Children: Mental Health Professionals A Comparative Study M.S. Bhatia Nabat Arfi, Farzana Alim, Suhail Ahmad Azmi To Assess and Compare the Depression and 63 Review Articles Psychosis in Patients following Caesarean Body Image Dissatisfaction and its Psychological 7 Section and Vaginal Delivery Outcomes: An Overview Priyanka Bhardwaj, Sandeep Choudhary, Kanchan Verma, Saroj Verma S. Sudarsanan, Sachin Sharma Empowering Children – Age Appropriate 16 Gender Differences in Prenting Stress in 68 Sex Education Caregivers of Children with Intellectual Sumit Rana, Om Sai Ramesh V., Prerna Kukreti Disability Shiv Prasad, Dinesh Kataria Shahzadi Malhotra, Waheeda Khan, M.S. Bhatia Original Articles Efficacy of Electroconvulsive Therapy in 72 Serum Testosterone levels and Suicide in first 23 patients with Mental Illnesses: A Socio- episode Schizophrenia: A longitudinal clinical demographic and Clinical Profile Study study Ajeet Sidana, Jasmine Brar, Subhash Das, Sharouq Motwani, Sagar Karia, Avinash De Sousa Prinka Arora Nilesh Shah, Amresh Shrivastava A Comparative Study of Stress Level in 77 Disability and its Correlation with Symptom 28 Siblings of Children with and without Domains of Schizophrenia: A cross Sectional Disability hospital based study Surbhi Sharma, Shahzadi Malhotra Azmi Naaz, Suhail, Ahmed Azmi Perceived Stress and Coping Strategies in 82 Psychiatric Co-Morbidity in Alcohol, Nicotine 33 females with Psychogenic Non-Epileptic and Alcohol – Nicotine Dependent Patients Seizures in a Tertiary Care Hospital, New Delhi Jaskaranjit Singh Litt, Tushar Jagawat, Richa Mehta, Anuj Mittal, Dweep Chand Singh Krishna Kanwal, Bajrang Lal, Pankaj Tandon Chirag Patel Assessment of Anxiety symptoms among 42 medical Students at the time of joining and Prevalence, Predictors and Comorbidity of 89 after one year Dissociative Disorder Patients at a Tertiary Ripu Daman Singh, Shri Gopal Goyal, Care Centre in North India: A cross sectional K.K. Verma, Girish Chandra Baniya, study Prem Prakash Mahboobul Hasan Ansari, Rakesh Kumar Gaur Pattern of substance use and the socio- 47 Kishan Chand Gurnani, Vishal Sinha, demographic variables among urban adolescents: Faisal Shaan A hospital-based study Audit of Assessment of Metabolic Syndrome in 95 Roopam Kumari, Namita Deka, Dinesh Tyagi Patients with Schizophrenia on Antipsychotic Medications To understand Personality Characteristics of 53 Shambhavi Jaiman, Santosh Prabhu, the Substance abusers and its Contribution Shishir Kumar, Shrinivasa Bhat U. to the Addictive nature Rupesh Chaudhary, Pankaj Kumar, Factoral Validation of Connor Davidson 99 Bholesh Prasad Mishra Resilience scale on Indian Sample Usama Rehman, M.G. Shahnawaz Delhi Psychiatry Journal 2019; 22:(1) © Delhi Psychiatric Society 3 DELHI PSYCHIATRY JOURNAL Vol. 22 No. 1 APRIL 2019 Study of Perceived Stress in Undergraduate 105 Single Parenthood Families and their impact 161 Medical Students in a Private Medical on children in India College in Tamil Nadu Nasir Ahamd Bhat, R.R. Patil K. Monicka Depression and Anxiety in patients of chronic 114 View Point obstructive pulmonary disease at tertiary Is the patient centric Mental Health Care 166 care hospital Act indeed patient centric – a clinical Gaurav Bhardwaj, Priyanka Bhardwaj perspective Pragya Lodha, Avinash De Sousa Group Therapy Minimize Craving in Individuals 118 with Alcohol Dependence Drug Review Prem Prakash, Amool Ranjan Singh Evenamide – A New Hope for Treatment 171 Resistant Schizophrenia Public Lectures In Psychiatry: An Highly 126 M.S. Bhatia, Aparna Goyal, N.C. Priyadarshini Beneficial Yet Cost-Effective Tool Kuldip Kumar, Rupam Dhiman Case Reports Amitriptyline Induced Restless Legs 175 Role of Group Therapy in the Enhancement 131 Syndrome of Social Skills in Schizophrenia Parijat Roy, Heena Merchant, Nilesh Shah, Vishmita, Amool Ranjan Singh Avinash Desousa Psychomicrobiology A case of Bipolar affective disorder with 177 Psychological Aspects of Swine Flu 139 auto-immune encephalitis: Diagnostic and Nirmaljit Kaur, Shalini Malhotra, management approach Nandini Duggal, M.S. Bhatia Ajeet Sidana, Ramandeep Kaur, Nishit Sawal Psychophysiotherapy Sleep Bruxism due to Paroxetine 180 Management of Obesity in Children and 144 Navneet Kaur Bhatia, Navleen Kaur Bhatia, Adolescents–Psychophysiotherapeutic M.S. Bhatia Approach Jaswinder Kaur, Megha Masaun, M.S. Bhatia Book Review Inhalant Addiction – “The Silent Epidemic” 183 Psychophysical Aspects of Cardiac 151 M.S. Bhatia, Aparna Goyal Rehabilitation Jaswinder Kaur, Mansi Gupta, M.S. Bhatia Interesting Articles 184 Forthcoming Events 186 Commentary Drug Addiction among Kashmiri Youth and 158 Instructions to authors 190 Prevention Thereof Nuzhat Firdous 4 Delhi Psychiatry Journal 2019; 22:(1) © Delhi Psychiatric Society APRIL 2019 DELHI PSYCHIATRY JOURNAL Vol. 22 No. 1 Editorial Psychoeconomics – The Upcoming Role of Mental Health Professionals M.S. Bhatia Department of Psychiatry, UCMS & GTB Hospital, Dilshad Garden, Delhi-110095 Psychoeconomics is a field that uses techni- effectively referring individuals for specialist debt ques from psychology and economics.1 It is also counselling and monitoring progress; and also called behavioral finance. assessing whether patients have sufficient mental A number of studies on UK based students have capacity (i.e. financial capacity) to manage their shown that mental health problems are linked to finances and if required, assigning control of finances financial problems,2 level of debt3 and concern about to appointees and attorneys.13 finances.4 Government surveys in UK found that 1 Understanding the stages and mechanisms in 11 people report debt or arrears but in individuals through which a manageable debt becomes a with mental health problems,5 this figure increases problem debt can help mental health professionals to 1 in 4. Greater financial difficulties predicted act before a full-blown crisis occurs. There is a debt greater depression and stress.6 Anxiety and alcohol spiral, which consists of missed payments and dependence also predicted worsening financial penalties; juggling finances; creditor pressure; situation suggesting a bi-directional relationship.6 financial breakdown; unrealistic arrangements; legal Around 9% of people without mental health proceedings and finally, total loss.13 problems reported debt or arrears, whereas 24% of The psychiatrists can face difficult challenges individuals with neurotic conditions and 33% of those when dealing with individuals who are accruing with psychotic conditions were in debt.5 37% patients problem debt (i.e. falling behind with payments) or assessed after an act of self-poisoning were in debt7 priority debt (resulting in loss of essential services and the difficulties in repaying debts is an or court action resulting in loss of liberty) but have independent predictor
Load more

Recommended publications
  • Edison Healthcare Insight
    Edison Healthcare Insight December 2020 Published by Edison Investment Research The Edison healthcare team www.edisongroup.com Maxim Jacobs Dr Nathaniel Calloway Max joined Edison’s healthcare team in December Nathaniel Calloway joined the healthcare team in 2014. Prior to this he worked as a senior analyst at December 2015. Before Edison, he performed Guidepoint Global. Max has also previously worked healthcare investment research for a fund at Bishop as a senior analyst at Ridgemark Capital, a sector Rosen and for Wainscott Capital Partners. Prior to head at Broadfin Capital and as a senior analyst at his role as an analyst he performed molecular Mehta Partners. He is a CFA charter holder. neuroscience research at Cornell Medical School and holds a PhD in chemistry from Cornell. He has published eight scientific papers on topics ranging from physical chemistry to immunology, and he has been recognised as an American Heart Association fellow and an American Chemical Society Medicinal Chemistry fellow. Pooya Hemami Dr John Savin Pooya is a licensed optometrist with over five years John is an analyst working on biotech, pharma, of experience in life sciences equity research. Prior medical device and diagnostics companies. As to joining Edison, he covered the Canadian founder CEO of Physiomics, he devised the healthcare sector as a research analyst at strategy, raised funds and took the company to AIM Desjardins Capital Markets. He holds a doctor of in 2004. At Greig Middleton, John was director in optometry degree from the University of Montreal, charge of the pharma and biotech analyst team and and an MBA (finance concentration) from McGill worked with corporate finance on fund-raising, IPOs University.
    [Show full text]
  • Glutamate and Microglia Activation As a Driver of Dendritic Apoptosis: a Core Pathophysiological Mechanism to Understand Schizop
    Parellada and Gassó Translational Psychiatry (2021) 11:271 https://doi.org/10.1038/s41398-021-01385-9 Translational Psychiatry PERSPECTIVE Open Access Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia Eduard Parellada 1,2,3 and Patricia Gassó 1,2,4 Abstract Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent findings from genetics, molecular biology, neuroimaging, animal models and translational clinical research offers evidence that the synaptic overpruning hypothesis of schizophrenia needs to be reassessed. During a critical period of neurodevelopment and owing to an imbalance of excitatory glutamatergic pyramidal neurons and inhibitory GABAergic interneurons, a regionally-located glutamate storm might occur, triggering excessive dendritic pruning with the activation of local dendritic apoptosis machinery. The apoptotic loss of dendritic spines would be aggravated by microglia activation through a recently described signaling system from complement abnormalities and proteins of the MHC, thus implicating the immune system in schizophrenia. Overpruning of dendritic spines coupled with aberrant synaptic plasticity, an essential function for learning and memory, would lead to brain misconnections and synaptic inefficiency underlying the primary negative symptoms and cognitive deficits of schizophrenia. This driving hypothesis has relevant therapeutic implications, including the importance of pharmacological interventions during
    [Show full text]
  • Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
    US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG .
    [Show full text]
  • Newron Pharmaceuticals FY18 Results
    Newron Pharmaceuticals FY18 results Moving towards R&D inflection points Pharma & biotech 14 March 2019 Newron’s FY18 highlights the steady progression of its CNS R&D pipeline. STARS the pivotal Phase II/III (Sarizotan for Rett’s Syndrome) has Price CHF8.29 completed enrolment and data are expected in Q419. Newron is planning Market cap CHF148m to apply for a global filing and approval strategy once data are available. €0.88:CHF; $1.00:CHF; $1.13:€ Evenamide (schizophrenia), developed internally through Newron’s ion Net cash (€m) at 31 December 2018 43.9 channel discovery platform, could enable a paradigm shift in the treatment Shares in issue 17.8m of refractory schizophrenia patients; in Q219 Newron will initiate two pivotal Phase IIb/III trials. We value Newron at CHF714m. Free float 95% Code NWRN Revenue PBT* EPS* DPS P/E Yield Primary exchange SIX Year end (€m) (€m) (€) (€) (x) (%) Secondary exchange N/A 12/17 13.4 (5.3) (0.32) 0.0 N/A N/A 12/18 4.0 (15.0) (0.84) 0.0 N/A N/A Share price performance 12/19e 8.5 (30.2) (1.69) 0.0 N/A N/A 12/20e 21.6 (8.7) (0.49) 0.0 N/A N/A Note: *PBT and EPS are normalised, excluding amortisation of acquired intangibles, exceptional items and share-based payments. Xadago ramp up required Newron reported €4.0m in Xadago royalties in FY18 (vs €2.9m in FY17). We assume 8–15% royalty rate depending on country, this implies gross sales of c €50m for the period generated in countries launched in Europe and initial US sales.
    [Show full text]
  • Howard Hassman, DO, AOBFP
    Curriculum Vitae, Howard A. Hassman, D.O., A.O.B.F.P. Howard A. Hassman, D.O., A.O.B.F.P. CEO, Apex Innovative Sciences CEO, Hassman Research Institute, LLC 175 Cross Keys Road 401 Route 73 North Centennial Center, Bldg. 300 B 30 Lake Center Executive Park, Suite 100 Berlin, NJ 08009 Marlton, NJ 08053 CONTACT INFORMATION: Site Selection and Information: Site Contact: Bobbie Theodore, VP Sponsor Relations/BD Mitchell Hassman, MBA, Director of BD Apex Innovative Sciences, Alliance Division Tel. (856) 753-7335 x 350 Tel. 916-803-7149 (cell) Fax (856) 306-6590 Email: [email protected] Email: [email protected] AFFILIATIONS: Berlin Medical Associates Comprehensive Clinical Research 175 Cross Keys Rd, Suite 300A 175 Cross Keys Road Berlin, NJ 08009 Berlin, NJ 08009 EDUCATION: 1979 - 1983 PA Osteopathic Physician and Surgeon, D.O. Philadelphia College of Osteopathic Medicine, Philadelphia, PA 1978 - 1979 Drexel University, Philadelphia 1974 - 1978 BS, Fairleigh Dickinson University, Madison, NJ INTERNSHIP: 1983 - 1984 Rotating Internship University of Medicine and Dentistry, John F. Kennedy Memorial Hospital Stratford, Cherry Hill, and Washington Township Divisions, NJ CERTIFICATION: Board Certified in Family Practice LICENSURE: Available upon request Updated 4/27/21 1 Curriculum Vitae, Howard A. Hassman, D.O., A.O.B.F.P. PROFESSIONAL EXPERIENCE: Chief Executive Officer, 2019-present Apex Innovative Sciences Chief Executive Officer and Principal Investigator, 2016 - present Hassman Research Institute, LLC, Berlin, NJ Principal
    [Show full text]
  • Newron Announces Results of Explanatory Studies with Evenamide in Healthy Volunteers and Patients with Schizophrenia
    Newron announces results of explanatory studies with evenamide in healthy volunteers and patients with schizophrenia Primary objective of safety of evenamide met on all safety variables for study 010 in healthy volunteers and study 008 in patients with schizophrenia Additional safety and efficacy study 008A in therapeutic dose (30 mg BID) to start in April 2021 Milan, Italy and Morristown, NJ, USA, April 1, 2021 – Newron Pharmaceuticals S.p.A. (“Newron”) (SIX: NWRN, XETRA: NP5), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system, today announced initial results from two short-term explanatory studies in evenamide: study 010 in healthy volunteers and study 008 in patients with schizophrenia. Results from study 010, a four-week, single dose, cross-over Thorough QT (TQT) study in 56 healthy volunteers, designed to evaluate the effects of evenamide (30 mg and 60 mg) compared with placebo and moxifloxacin 400 mg on the QT segment specifically, and on the electrocardiogram (ECG) generally, was requested by the US Food and Drug Administration (FDA) and under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). The results indicate that evenamide was devoid of any QTcF prolongation compared to placebo (indicating lack of any increased risk of arrythmia), while moxifloxacin was associated with a 17.3 ms median maximum increase suggestive of clinically significant risk of arrhythmia. These results strongly suggest that evenamide does not increase a patient’s risk of QTc prolongation and arrhythmias, a risk generally associated with antipsychotics.
    [Show full text]
  • P.3.F.022 Evenamide (Formerly NW-3509) Targets New Mechanisms, and Represents a New Approach to the Management of Untreated Symptoms in Schizophrenia Faravelli1, R
    P.3.f.022 Evenamide (formerly NW-3509) targets new mechanisms, and represents a new approach to the management of untreated symptoms in schizophrenia Faravelli1, R. Anand2, E. Forrest3. 1, 3 NEWRON Pharmaceuticals SPA, Bresso - Milan, Italy. 2 APC, AG, St. Moritz, Switzerland. Introduction Three large, independent (non-commercial), randomized clinical trials comparing first- and second-generation antipsychotics performed in the US, UK, and Europe have indicated no clinically meaningful differences in the effectiveness of first (FGA) vs second generation (SGA) antipsychotics. The CATIE study (US) [1] showed high rates of discontinuation due to unsatisfactory response for all antipsychotics tested, the CUTLASS (UK) [2] second study found no meaningful differences in Quality of life, or patient preference for FGA vs SGA, while the EUFEST (EU) [3] study found that although discontinuations were higher for haloperidol, there was no difference in symptom reduction between FGA and SGA in patients with first episode psychosis. Clozapine outperformed other second-generation drugs in the CATIE and CUTLASS studies where it was tested. These results raise numerous questions relating to the neurochemical changes needed to provide meaningful benefit to patients with schizophrenia. All currently available FGA and SGA, except clozapine, act through minor variations of monoaminergic modulation, therefore their therapeutic effects are similar. These observations and increasing evidence that hippocampal hyperactivity, glutamatergic abnormalities, and aberrant
    [Show full text]
  • Rett Syndrome
    7 June 2017 This report has been issued for information purposes only and is not intended to constitute investment advice. It is based on estimates and forecasts of third parties regarding revenues, earnings and business developments. Such estimates and forecasts cannot be independently verified by reason of the subjective character. Newron Pharmaceuticals S.p.A. gives no guarantee, representation or warranty and is not responsible or liable as to its accuracy and completeness. Please see important research disclosures at the end of this document Page 1 of 43 VALUATIONLAB | [email protected] | Valuation Report | June 2017 7 June 2017 VALUATIONLAB FINANCIAL ANALYSIS NEWRON PHARMACEUTICALS FOCUS AREA: DISEASES OF THE CENTRAL NERVOUS SYSTEM (CNS) AND ORPHAN DISEASES KEY DATA SIX: NWRN MARKET CAPITALIZATION (CHF MN) 330 PRICE ON JUNE 07, 2017 20.9 ENTERPRISE VALUE (CHF MN) 279 RISK-ADJUSTED NPV PER SHARE * (CHF) 45 CASH (31 DECEMBER 2016) (CHF MN) 51 UPSIDE/DOWNSIDE (%) 114% MONTHLY OPERATING EXPENSE (CHF MN) 2.8 RISK PROFILE HIGH RISK CASH LIFE (YEAR) 2019 SUCCESS PROBABILITY LEAD PIPELINE DRUG 25% BREAK-EVEN (EXCL. MILESTONES) (YEAR) 2019 EMPLOYEES (GROUP) 24 FOUNDED (YEAR) 1998 LISTED (YEAR) 2006 KEY PRODUCTS: STATUS MAJOR SHAREHOLDERS: (%) - XADAGO (PARKINSON'S DISEASE) APPROVED - DUBA AB (INVESTOR AB) 11.2 - SARIZOTAN (RETT SYNDROME) PHASE III - ZAMBON GROUP 8.3 - EVENAMIDE (SCHIZOPHRENIA) PHASE II - AVIVA 8.3 - EXECUTIVE MANAGEMENT 0.5 - FREE FLOAT 99.5 - AVERAGE TRADING VOLUME (30-DAYS) 53,352 UPCOMING CATALYSTS: DATE ANALYST(S):
    [Show full text]
  • P.3.D.030 Evenamide, a Voltage-Gated Sodium Channel Blocker in the Treatment of Schizophrenia
    P.3 .d .0 3 0 Evenamide, a voltage-gated sodium channel blocker in the treatment of schizophrenia: results from the placebo-controlled Study 002 3 1 4 2 1 Ravi Anand , Emma Forrest , Richard Hartman , Stephen M. Graham , Laura Faravelli 1 Newron Pharmaceuticals SpA, Bresso (MI), Italy, 2 Newron Pharmaceuticals US, Inc., Morristown, NJ, USA, 3 APC, AG, St. Moritz, Switzerland, 4 NeurWrite LLC, Morristown, NJ, USA Introduction Currently available antipsychotics that block dopaminergic, serotoninergic, and histaminergic transmission have failed to provide effective control of symptoms of psychosis (CATIE, CUTLASS, and EUFEST). Evenamide (NW-3509A), a potent anti-epileptic is a totally selective inhibitor of voltage- gated sodium channels and attenuates the stimulated release of glutamate, as shown in in-vivo micro-dialysis. It is effective in animal models of psychosis, mood disorders, aggression, negative symptoms, and cognitive dysfunction, both as monotherapy and as add-on treatment. A study in healthy male volunteers evaluating single doses of 1 to 30 mg of evenamide indicated that its Tmax was 1.5-2.0 hr, half-life (t1/2) was 1.1-4.7 hrs; its Cmax and AUC(0-t) increased proportionately with increasing dose. Cmax values of >20 ng/ml, exceeding projected effective exposures (based on PBPK modelling of results of in-vitro/ in-vivo studies), were noted at doses of 20 mg and higher. These results were followed by the conduct of Study 002, a placebo-controlled, randomized study, with a dose range of 15-25 mg BID evenamide as an add-on to patients with schizophrenia who were on stable doses of risperidone or aripiprazole.
    [Show full text]
  • Edison Healthcare Insight
    EDISON HEALTHCARE INSIGHT July 2021 Published by Edison Investment Research The Edison healthcare team www.edisongroup.com Maxim Jacobs Pooya Hemami Max joined Edison’s healthcare team in Pooya joined Edison's healthcare team in December 2014. Prior to this he worked as a November 2012 and took on additional duties as senior analyst at Guidepoint Global. Max has a supervisory analyst in early 2019. He is a also previously worked as a senior analyst at licensed optometrist with several years of clinical Ridgemark Capital, a sector head at Broadfin practice and regulatory experience. Prior to Capital and as a senior analyst at Mehta joining Edison, he covered the Canadian Partners. He is a CFA charter holder. healthcare sector as a research analyst at Desjardins Capital Markets. Pooya holds a Doctor of Optometry degree from the University of Montreal, and an MBA (finance concentration) from McGill University. He received his CFA charter in 2011. Dr Susie Jana Dr John Savin Susie joined the team in September 2015 and John is an analyst working on biotech, pharma, has 16 years’ experience in the healthcare medical device and diagnostics companies. As sector. She is a qualified medical doctor, having founder CEO of Physiomics, he devised the studied medicine at UCL. She also holds an strategy, raised funds and took the company to intercalated BSc in psychology. After a few AIM in 2004. At Greig Middleton, John was years working as a junior doctor in the NHS, director in charge of the pharma and biotech Susie joined the investment banking industry for analyst team and worked with corporate finance six years on the sell-side covering biotechnology on fund-raising, IPOs and corporate stocks, then mid- to large-cap pharmaceuticals restructuring.
    [Show full text]
  • Human Medicines Regulations 2012 Advisory Bodies Annual Report 2017
    Human Medicines Regulations 2012 Advisory Bodies Annual Report 2017 Commission on Human Medicines British Pharmacopoeia Commission Medicines & Healthcare products Regulatory Agency HUMAN MEDICINES REGULATIONS 2012 ADVISORY BODIES ANNUAL REPORT 2017 Laid before Parliament pursuant to Part 2, Section 12 (4) of the Human Medicines Regulations 2012 Commission on Human Medicines British Pharmacopoeia Commission Contact for information about these reports: Oliver Stokes Expert Committee Support 151 Buckingham Palace Road London SW1W 9SZ 020 3080 6550 © Crown copyright 2018 Published by the Medicine & Healthcare products Regulatory Agency ISBN 978-1-900731-17-1 You may re-use this information (excluding logos) free of charge in any format or medium, under the terms of the Open Government Licence. To view this licence, visit nationalarchives.gov.uk/doc/open-government- licence/version/2/ or email [email protected] Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. Any enquiries regarding this publication should be sent to the MHRA at: Medicines & Healthcare products Regulatory Agency Information Services 151 Buckingham Palace Road London SW1W 9SZ 020 3080 6000 E-mail: [email protected] You can download this publication from https://www.gov.uk/mhra LIST OF CONTENTS Foreword Report on the Commission on Human Medicines 1 Report of the British Pharmacopoeia Commission 103 Code of Practice for Chairmen and Members of the Commission on Human 128 Medicines,
    [Show full text]
  • Evenamide - a Novel Mechanism / Treatment Paradigm for Schizophrenia – Poc Demonstrated; HA Review of Potentially Pivotal Studies’ Design Ongoing 5
    SUCCESS IN CNS DRUG DEVELOPMENT – INNOVATION IN RARE DISEASES Corporate presentation June, 2018 Disclaimer RESTRICTED SCOPE; EXCLUSION OF LIABILITY; CONFIDENTIALITY This document has been prepared by Newron Pharmaceuticals S.p.A. ("Newron") solely for your information. The information contained herein has not been independently verified. No representation or warranty, express or implied, is made as to, and no reliance should be placed on, the fairness, accuracy, completeness or correctness of the information or opinions contained herein. Newron does not undertake any obligation to up-date or revise any information contained in this presentation. None of Newron, its advisors or any of their respective representatives or affiliates shall have any liability whatsoever (in negligence or otherwise) for any loss howsoever arising from any use of this document or its contents or otherwise arising in connection with this document. None of Jefferies International Limited ("Jefferies"), Kempen & Co N.V. (“Kempen”) or Kepler Cheuvreux S.A. (“Kepler”) or any of their respective directors, officers, employees, advisers and agents accept any responsibility or liability whatsoever for/or makes any representation or warranty, express or implied, as to the truth, fullness, accuracy or completeness of the information in this document (or whether any information has been omitted from the document) or any other information relating to Newron or its associated companies, whether written, oral or in a visual or electronic form, and howsoever transmitted or made available or for any loss howsoever arising from any use of this document or its contents or otherwise arising in connection therewith. None of Newron, Jefferies, Kempen, Kepler or any of their respective directors, officers, employees, agents, affiliates or advisers is under any obligation to update, complete, revise or keep current the information contained in this document to which it relates or to provide the recipient of with access to any additional information that may arise in connection with it.
    [Show full text]