RTN4RL2 Antibody Cat. No.: 7145

RTN4RL2 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)

Rabbit polyclonal RTN4RL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RTN4RL2. IMMUNOGEN:

The immunogen is located within amino acids 330 - 380 of RTN4RL2.

TESTED APPLICATIONS: ELISA, WB

RTN4RL2 antibody can be used for detection of RTN4RL2 by Western blot at 1 - 2 μg/mL.

APPLICATIONS: Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is SPECIFICITY: predicted to not cross-react with other Nogo receptor-like proteins.

POSITIVE CONTROL: 1) Cat. No. 1463 - Rat Brain Tissue Lysate

PREDICTED MOLECULAR Predicted: 46 kDa WEIGHT:

Properties

September 27, 2021 1 https://www.prosci-inc.com/rtn4rl2-antibody-7145.html PURIFICATION: RTN4RL2 Antibody is affinity chromatography purified via peptide column.

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: RTN4RL2 Antibody is supplied in PBS containing 0.02% sodium azide.

CONCENTRATION: 1 mg/mL

RTN4RL2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one STORAGE CONDITIONS: year.

Additional Info

OFFICIAL SYMBOL: RTN4RL2

RTN4RL2 Antibody: NgR2, NGRH1, NGRL3, Reticulon-4 receptor-like 2, Nogo receptor-like ALTERNATE NAMES: 3, NgR2

ACCESSION NO.: NP_848665

PROTEIN GI NO.: 30425563

GENE ID: 349667

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

RTN4RL2 Antibody: Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich BACKGROUND: sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

1) Pignot V, Hein AE, Barske C, et al. Characterization of two novel proteins, NgRH1 and REFERENCES: NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J. Neurochem. 2003; 85:717-28.

2) Venkatesh K, Chivatakam O, Lee H, et al. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J. Neurosci. 2005; 25:808-22.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 27, 2021 2 https://www.prosci-inc.com/rtn4rl2-antibody-7145.html