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Curriculum Vitae -2014 Curriculum Vitae -2014 PERSONAL DETAILS Dr Mohammed Almaghrabi Kingdom of Saudi Arabia Nationality: Saudi Passport No: M838201 Date of Birth: 10. Jul. 1975. Place of Issue: Abha Marital Status: Married Date of issue: 05/May/2014 Religion: Muslim Date of Expiry: 13/March/2019 Current Address : Contact Details: King Khalid University [email protected] School of Medicine Mobile No: +966(0)531625617 Microbiology Dept. Abha, Saudi Arabia. P.O Box: 641 EXPERIENCE 28 Oct. 2013 to current Assistant Professor at College of medicine, King Khalid University, Abha, Saudi Arabia. EDUCATION 29 July 2008 – 05 May 2013 PhD in Infection, Immunity and Inflammation Dept. School of medicine and Biological science. The University of Leicester. Thesis topic: (The isolation of Streptococcus pneumoniae lytic phages and their in vitro and in vivo interaction) 28/Sept. 2006- 21/May 2008 MSc. (Medical and Molecular Microbiology) faculty of medical & human sciences, school of medicine, department of medical microbiology, the University of Manchester. Dissertation Topic: (EVALUATION OF VIRAL DNA 20 Mar- 15 Sept. 2006 ISOLATION USING FTA FILTER PAPER FOR USE IN PCR) English Course (University of Manchester) 1993-1998 BSc. Microbiology, Faculty of Applied Science, Umm Alqura University, Makkah, Saudi Arabia. The PhD Project: The project describe the isolation of Streptococcus pneumoniae lytic phages and their in vitro and in vivo interaction. It was undertaken as alternative approach to control and treat the infection caused by this bacterium. The project supervised by two pioneer scientists who are shown below as academic references. Streptococcus pneumoniae is a major global human pathogen with an annual death toll of over 1 million people. The limited treatment and control options mean that is an urgent need for novel effective therapies to treat infected patients. Here we describe a newly isolated bacteriophage that could be used to treat invasive S. pneumoniae by lysing bacterial cells in the respiratory tract or in blood. Capsulated invasive pneumococci were used to isolate the phage. Purified phage preparations were shown to clear capsulated pneumococci in culture and in mouse models of invasive pneumonia and sepsis. Mice treated by bacteriophages showed a significant reduction of S. pneumoniae colony forming units in lungs and blood. The bacteriophage was sequenced and is strictly virulent and doesn’t encode any recognisable toxins. This represents a promising therapeutic strategy against pneumococcal sepsis in particular by highly invasive strains that have evaded vaccination, or are resistant to existing antibiotics. The two examiners; Dr Sophie Foley (external) and Dr Edward Galyov (internal), extremely impressed with the terrific findings achieved in this project and recommended to publish them in high impact factor journals. Practical Experience: 1- Laboratory demonstrator in six week courses programme for four years from 2009 to 2012. 2- Demonstrator at King khalid University, college of medicine, Microbiology Dept. (14th Sept. 2003 to 1st Mar.2006). 3- Technologist (Diagnostic and Admen.): College of Health Science (14th Apr 2001 to 14th Sept 2003). 4- Technologist (Diagnostic): Ministry of Health (12th Oct 1999 to 13th Apr. 2001). Administrative experience: 1- Head of creativity, giftedness and entrepreneurship centre, King Khalid university from Feb. 2016 till now. 2- Vice principle of creativity and giftedness centre, King Khalid university from Feb. 2015 till Feb. 2016. 3- Head of the department of medical laboratory sciences in the college of Medical Applied, King Khalid University from 16 Nov 2013 to 22 May 2014. 4- Head of Muslim welfare house in Leicester from July 2009 to July 2010 and continued as a member in that organisation for two years more. 5- Head of the department of medical laboratories in the collage of health sciences during the academic year of 2003. 6- Head of laboratory and blood bank department in Abha general hospital from January to April 2001. Training courses In diagnostic microbiology: 1- Ajiad Hospital, Makkah, KSA 2- King Fahad Hospital, Jeddah, KSA In Food Microbiology: 1- Food Quality Control Laboratory, National Food company, Jeddah,KSA. 2- Food Quality Laboratory, King Abdulaziz Sea Port Laboratory, Dammam Conferences: st 1. 21 Biennial Evergreen International Meeting, Evergreen Phage Lab, August 2-7, 2015, Olympia, Washington, USA. 2. Gram-Negative Resistance (D1), Keyston Symposia, March 29- April 02, 2015, Tahoe city, California, USA. 3. 114 General meeting, American Society for Microbiology, May 17-20, 2014, Boston, Massachusetts, USA. 4. Bacteriophages: Nature & Exploitation, 2008, Welwyn Garden City, England. th 5. 10 European Meeting on the Molecular Biology of the Pneumococcus "the Royal Netherland Society of Art and Sciences"- 23th – 26th June 2011- Amsterdam, The Netherland. 6. Society for General Microbiology Irish Division Meeting " Microbial Viruses: Genomics, Evolution and Applied in Ecology, Biotechnology and Medicine" April 19th – 20th 2011- Belfast, Northern Ireland. 7. Evergreen International Phage Biology Meeting – Aug. 9-14 2010 – Olympia, WA. 8. 1st International Congress “Viruses of Microbes”, 2009, Paris, France (Co-organizer of the Congress). th 9. 114 General Meeting of American Society for Microbiology, May 17-20, 2014, Boston, Massachusetts, The United States. Conference publications: 1. Mohammed Almaghrabi, M Joseph; M Hamid; M Assiry, Antimicrobial and molecular analysis of Acinetobacter baumannii - An emerging health threat in Aseer region, Gram-Negative resistance, Tahoe city, California, USA. 2. Mohammed Almaghrabi, Daniel R Neill, Aras Kadioglu and Martha Clokie, June 2011, The isolation and characterisation of Streptococcus pneumoniae lytic phages and their in vitro and in vivo interactions, 2011, 10th European Meeting on the Molecular Biology of the Pneumococcus " the Royal Netherland Society of Art and Sciences, Amsterdam, The Netherland. 3. Mohammed Almaghrabi, Daniel R Neill, Aras Kadioglu and Martha Clokie, April 2011, The isolation and characterisation of Streptococcus pneumoniae lytic phages and their in vitro and in vivo interactions, Society for General Microbiology Irish Division Meeting " Microbial Viruses: Genomics, Evolution and Applied in Ecology, Biotechnology and Medicine". Belfast. 4. Mohammed Almaghrabi, Aras Kadioglu and Martha Clokie, 2010, The isolation of lytic phages against Streptococcus pneumoniae and their in vitro and in vivo interactions, Evergreen International Phage Biology Meeting – Aug. 9-14 2010 – Olympia, WA. 5. Mohammed Almaghrabi, Aras Kadioglu and Martha Clokie, 2009, The isolation of pneumococcal lytic phages, 1st International Congress “Viruses of Microbes”, Paris, France. Publications: 1- Almaghrabi M, K, Alwadei A, D, Alyahya N, M, Alotaibi F, M, Alqahtani A, H, Alahmari K, A, Alqahtani M, S, Alayed A, S, Moosa R, Ali A, S: Seroprevalence of Human Cytomegalovirus in Pregnant Women in the Asir Region, Kingdom of Saudi Arabia. Intervirology 2020. doi: 10.1159/000506051 2- Almaghrabi MK, Antimicrobial activity of Salvadora persica on Streptococcus pneumoniae, Biomedical Research (2018) Volume 29, Issue 19 3- Almaghrabi MK, Joseph MR, Assiry MM, Hamid ME. Multidrug-resistant Acinetobacter baumannii: an emerging health threat in Aseer Region, Kingdom of Saudi Arabia. Can J Infect Dis Med Microbiol. 2018;2018. doi:10.1155/2018/9182747. 4- Mohammed Almaghrabi, Ali Alshamrani, Merie A, Abdulwahab A, Abdullah M A.The Most Common Causative Organisms Causing Meningitis in Abha Maternity and Children Hospital, Abha, Saudi Arabia. J Gynecol Women’s Health. 2018: 11(2): 555804. DOI: 10.19080/JGWH.2018.11.555804 5- Mohammed K. Almaghrabi, Mohamed E. A. Hamid, Mohammed Assiry, Martin Joseph (2015), Multidrug Resistant Acinetobacter baumannii: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia, Canadian Journal of Infectious Diseases and Medical Microbiology, In press 6- Al-Zaydani, I. A., Al-Hakami, A. M., Joseph, M. R. P., Kassem, W. M., Almaghrabi, M. K., Nageeb, A., & Hamid, M. E. (2015). Aggressive cutaneous zygomycosis caused by Apophysomyces variabilis in an immunocompetent child. Medical Mycology Case Reports, 10, 11–13. 7- Syeed N, Hamali HAA, Alahmari KA, Al-Magribi MK, Hussain F (2014) Molecular Enhancers; Remote Controls the Differential Gene Expression during Development. J Carcinog & Mutagen 5:168. doi: 10.4172/2157-2518.1000168 REFERENCES: Dr Aras Kadioglu Dr Martha Clokie Professor of Bacterial Pathogenesis Reader in Microbiology Department of Clinical infection Microbiology & Department of Infection, Immunity and Inflammation Immunology Medical Sciences Building Institute of Infection & Global Health University of Leicester PO Box 138 University of Liverpool The Roland Ross Building Leicester 8 West Derby St LE1 9HN, U. K. Liverpool Tel: +44 (0)116-2522959 (Office) L69 7BE Fax: +44 (0) 116-2525030 Tel: +44 (0)151-7959612(Office) email: [email protected] Email: [email protected] .
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