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This is not registered version of Total HTML Converter The Explosives and Weapons Forum > C hemistry for Ama teur Experim ente rs and Citizen Scientists Lo g in View Full Version : Chemistry for Amateur Experimenters and Citizen Scientists General, Organic, and Improvised Chemistry Battlefield Chemistry Chemicals, Apparatus, and Equipment Biochemistry and Medicine Special Project 1: Improvised Manufacture of Nitric Acid vBulletin® v3.7.2, Copyright ©2000-2008, Jelsoft Enterprises Ltd. This is not registered version of Total HTML Converter The Explosives and Weapons Forum > Chemistry for Am ateur Expe rimenters and C itizen Scientists > Biochemistry and Medicine Log in View Full Version : Biochemistry and Medicine 1. Injection question (10 replies) 2. How to Dispose of a Body (Interesting Metafilter comment) (87 replies) 3. Medicines to stockpile (17 replies) 4. Acetylcholinesterase (Disruption and Changing) (3 replies) 5. Brevetoxins (8 replies) 6. 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This is not registered version of Total HTML Converter The Explosives and Weapons Forum > Chemistry for Amateur Experimenters and Citizen Scientists > Biochemistry and Medicine > Melatonin and other new knockout drugs Log in View Full Version : Melatonin and other new knockout drugs nbk2000 December 27th, 2001, 11:50 PM Been kicking around the idea of melatonin being useful in the criminal capacity, much as chloral hydrate and rohypnol have in the past. Melatonin is usually used in under 3mg quantities to help people fall asleep. I've been using it myself for that very purpose. But I made the logical next step in thinking that, if a little helps you sleep, that a LOT will PUT you to sleep, regardless. From what little research I have done, it appears that melatonin, besides being incredibly cheap and easy to obtain, has many of the characteristics of a good "mickey". To quote: "Within 20 minutes of taking the melatonin, he felt lethargic and disoriented...feeling unusually fatigued and sleepy. After 5 hours of sleep, he awoke appearing drugged and could not recall events of the previous evening" This was at 24 mg in a 60 year old man. Now, there's been toxicity studies performed with people taking 6 grams a day for a month. They didn't die, but they got sick with diarreha, flushing, etc. 1 gram caused a lethargic, sleepy state in young, healthy adults who basically couldn't stay awake. Add in alcohol which increases the effects, a half-life of 30-50 minutes, being a natural hormone (thus very difficult to differentiate in tox screens), and the best feature of all....never been used this way before. Adds up to some interesting "experimental" possibilities. Naturally you wouldn't want to try crushing up dozens of pills and dissolving all that powder in someones drink, but it shouldn't be very difficult to buy it as a pure powder from a chemical supplier since it is harmless, right? http://theforum.virtualave.net/ubb/smilies/wink.gif I take a 3mg pill every night to sleep very soundly, so I'll have to try taking 5 or 10 of them to see just how quickly (and solidly) I sleep. Wonder what it tastes like pure? Someone post the listing from the Merck CD (Forum FTP) here if it's listed, eh? ------------------ "I have begun evil, I shall end evil. That is the end that awaits me." Go here (http://briefcase.yahoo.com/nbk2k) to download the NBK2000 files and videos. Mr Cool December 28th, 2001, 07:57 AM Any idea what the filler(s) in the pills is/are? If it says, let us know what they are, maybe there'll be a way to separate them. I'm guessing talc and/or lactose... I think ordering it from a chemical supply house might have some problems, especially if it was discovered by the police that your victim had too much of it in their blood. ------------------ "Nothing makes a man fear much, more than to know little." - Francis Bacon. EventHorizon December 28th, 2001, 10:35 AM From Merck: Monograph number: 5857 Title: Melatonin CAS Registry number: [73-31-4] CAS name(s): N- [2-(5-Methoxy-1 H- indol-3-yl)eth yl]acetamide Additional name(s): N- acetyl-5-methoxytryptamine Trade name(s): Regulin (Young) Molecular formula: C<sub>13</sub>H<sub>16</sub>N<sub>2</sub>O<sub>2</sub> Molecular weight: 232.28 Percent Composition: C 67.22%, H 6.94%, N 12.06%, O 13.78% Literature references: A hormone of the pineal gland, also produced by extra-pineal tissues, that lightens skin color in amphibians by reversing the darkening effect of MSH, q.v. Melatonin has been postulated as the mediator of photic-induced antigonadotrophic activity in photoperiodic mammals and has also been shown to be involved in thermoregulation in some ectotherms and in affecting locomotor activity rhythms in sparrows. Isoln from the pineal glands of beef cattle: Ler ner et al., J. Am. Chem. Soc. 80, 2587 (1958); Wurtman et al., Science 141, 277 (1963). Structure: Lerner et al., J. Am. Chem. Soc. 81, 6084 (1959). Crystal and molecular structure: A. Wakahara, Chem. Lett. 1972, 1139. Synthesis from 5-methoxyindole as starting material by two different routes: Szmuszkovicz et al., J. Org. Chem. 25, 857 (1960). Biochemical role of melatonin: Chem. and Eng. News 45, 40 (May 1, 1967). Pharmacological studies: Barchas et al., Nature 214, 919 (1967). Identification of antigonadal action sites in mouse brain: J. D. Glass, G. R. Lynch, Science 214, 821 (1981). Binding studies in human hypothalamus: S. M. Reppert et al., Science 242, 78 (1988). Efficacy in control of estrus in red deer: G. W. Asher, Animal Reprod. Sci. 22, 145 (1990). Reviews: M. K. Vaughn, Int. J. Rev. Physiol. 24, 41-95 (1981); D. C.Klein et al., Life Sci. 28, 1975-1986 (1981). Book: Advan. Biosci. vol. 29, N. Birau, W. Schlott, Eds. (Pergamon Press, New York, 1981) 420 pp. Review of etiological role in clinical disease: A. Miles, D. Philbrick, CRC Crit. Rev. Clin. Lab. Sci. 25, 231-253 (1987); in psychi atric disorders: eidem, Biol. Psychiat. 23, 405-425 (1988). Properties: Pale yellow leaflets from benzene, mp 116-118degrees . uv max: 223 , 278 nm (epsi 27550, 6300) . Melting Point: 116-118 UV Maxima: 223; THERAP CAT (VET): Control of estrus. Nothing about LD's, etc. http://theforum.virtualave.net/ubb/smilies/frown.gif ------------------ "Chance favors a prepared mind" - Louis Pasteur "Happiness is a large pile of links." - Me PGP ID 0x147CEF54 [This message has been edited by EventHorizon (edited December 28, 2001).] CodeMason December 28th, 2001, 01:04 PM Speaking of Merck, I just got the CD rip off the Forum FTP, but I get the error "Insufficient data in INIT file" when I try to run it. Could anyone help me? ------------------ Live free or die! | http://codemason.cjb.net Ctrl_C December 28th, 2001, 02:59 PM i think i got that error the first time i ran it. try executing merck.exe straight out of the dir you installed to. i think i also reinstalled. its a bitch for some people to get to work but its well worth it when you do. ------------------ Long Ass Sig This is not registered version of Total HTML Converter BoB- December 28th, 2001, 03:50 PM I've taken valerian root and melatonin, I dont remember doses, but I do recall not being able to move, it felt like I hadnt slept in weeks. I slept for 12 hours that night. ------------------ Teamwork is essential. It lets you blame someone else. CyclonitePyro December 28th, 2001, 09:19 PM I bought these allergy pills one time in a New Jersey mini-mart on the way to the beach, I usually never have allergies but this was one of those "Murphy's Law" experiences. I still have the box and about half are left, they are very small. I first took one and I became very happy and drowsy, basically the same way I get when I take cough syrup. And whenever someone would say my name or something got my attention I would jump or be shocked for a second it's weird.