Ucla Stein Eye Institute

UCLA STEIN EYE INSTITUTE

ANNUAL REPORT 2019–2020

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Russia Canada United Kingdom

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Spain Armenia Turkey South United States Korea Greece Japan Syria China Israel Iraq Iran Jordan Pakistan Nepal Libya Mexico Egypt Saudi Bangladesh Arabia India Taiwan Hong Kong

Honduras Thailand Vietnam Philippines El Salvador Nigeria

Malaysia Colombia Uganda Singapore Ecuador Indonesia Peru Brazil

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Argentina South Africa

Impacting Eye Care on a Global Scale UCLA Stein Eye Institute ANNUAL REPORT

July 1, 2019–June 30, 2020

DIRECTOR Bartly J. Mondino, MD

MANAGING EDITOR Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 [email protected]

PUBLICATION COMMITTEE Anthony C. Arnold, MD Kevin M. Miller, MD Alfredo A. Sadun, MD, PhD Alapakkam P. Sampath, PhD

CONTRIBUTING EDITORS Lauren Bayans Teresa Closson Susan Ito Peter J. López Kara Mondino Ellen Pascual Darlene Villegas

CONTRIBUTING WRITERS Dan Gordon Harlan Lebo

PHOTOGRAPHY Reed Hutchinson Robin Weisz

DESIGN Robin Weisz/Graphic Design

PRINTING Marina Graphic Center

To view the Annual Report online, visit: www.uclahealth.org/Eye/annual-report.

For more information about the UCLA Department of Ophthalmology, see: www.uclahealth.org/eye/.

4 Year in Review

17 Philanthropy

25 Eye Health Programs

33 Faculty and Colleagues

69 Research and Funding

101 About the Institute LETTER FROM THE CHAIR

Scottish Poet Robert Burns wrote that, “The best laid schemes o’ mice an’ men / Gang aft a-gley.” And this academic year, the novel coronavirus (COVID-19) has certainly challenged our abilities to proceed in typical fashion. The safety of our patients, always of tantamount importance, has taken on new facets. Gary N. Holland, MD, Jack H. Skirball Chair in Ocular Inflammatory Diseases, has a leadership role in fighting against the spread of COVID-19 both here in the United States and beyond. A renowned infectious disease specialist, Dr. Holland and two colleagues were asked by the American Academy of Ophthalmology (AAO) to create guidelines for ophthalmologists on preventing transmission of this highly contagious virus during eye examinations and surgery. Their authored pages on the AAO website have been viewed over 1.5 million times as of this writing. Many of our educational events this academic year were cancelled or held remotely. During the pandemic’s height, our outpatient visits and surgical procedures were down to 25% of normal, and we were only seeing urgent or emergent cases. In the current ramp up, we are now at over 80% of pre-COVID levels for outpatient care and exceeding pre-COVID surgical cases, perhaps due to backlog. Preserving sight and ending avoidable blindness is our mission, and UCLA Department of Ophthalmology faculty, fellows, residents, and staff are committed to this challenge. Demonstrating true collaboration and selflessness, their priority—as it has been since the UCLA Stein Eye Institute opened its doors in 1966—is focused on the health and well-being of our patients. Private funding, especially in these uncertain times, remains critical to our ability to advance vision science and clinical care. I wish you and your family well, and I thank you for your support. Sincerely,

Bartly J. Mondino, MD Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Affiliation Chairman, Doheny Eye Institute Impacting Eye Care on a Global Scale

U.S.

Russia Canada United Kingdom

Switzerland France Romania Italy

Spain Armenia Turkey South United States Korea Greece Japan Syria China Israel Iraq Iran Jordan Pakistan Nepal Libya Mexico Egypt Saudi Bangladesh Arabia India Taiwan Hong Kong

Honduras Thailand Vietnam Philippines El Salvador Nigeria

Malaysia Colombia Uganda Singapore Ecuador Indonesia Peru Brazil

Chile Australia

Argentina South Africa

The UCLA Department of Ophthalmology’s renowned International Fellowship Program has trained more than 250 ophthalmologists from countries worldwide—doctors who not only become more accomplished clinicians and researchers, but also trailblazers for improving vision care around the globe.

A Year in Review | UCLA STEIN EYE INSTITUTE 1 UCLA INTERNATIONAL FELLOWSHIP PROGRAM

he International Fellowship Program is offered to ophthalmologists throughout the world and features a one-year immersion in training under the mentorship of faculty from the UCLA Department Tof Ophthalmology. The training for each fellow is unique— “I chose the Fellowship Program because of customized to meet the interests of the individual participant its international reputation, and also in subspecialties that include cataract; corneal-external ocu- because of my customized fellowship plan lar disease, uveitis, and refractive surgery; glaucoma; medical that combined exposure to the clinical and retina; neuro-ophthalmology; ophthalmic pathology; orbital and ophthalmic plastic surgery; pediatric ophthalmology research aspects of glaucoma with study of and strabismus; and vitreoretinal diseases. epidemiology and public health issues.” Since the Institute began training an annual cadre of international fellows in the early 1990s, more than 250 fellows FOTIS TOPOUZIS, MD from countries worldwide have been certified. The Program Chair, Department of Ophthalmology is distinctly positioned to train international fellows because Aristotle University of the unique strengths of the UCLA medical enterprise. The Thessaloniki, Greece broad range of services in premier UCLA-affiliated teaching hospitals and diverse patient populations across Southern California, depth of research programs, access to large-scale clinical trials, and connections to other medical and scientific programs on the UCLA campus provide an opportunity for enhanced study that is singular in ophthalmic training. “We work to inspire a sense of responsibility for leadership and innovation that our international fellows can use to train the next generation of ophthalmologists around the world,” says Bartly J. Mondino, MD, chair of the Department of Ophthalmology and director of the Stein Eye Institute. “We achieve our greatest success when our fellows become the innovators in their own countries.”

International expertise: a two-way exchange The Program promotes interaction in research and educa- “The International Fellowship Program has tion with ophthalmology institutions throughout the world, encouraging a two-way opportunity for learning, with the contributed significantly to shaping the international fellows and Department doctors sharing their careers of doctors in many countries, and expertise and methods for dealing with the unique chal- the Program has tirelessly contributed lenges for vision care and research. directly to the benefits of patients all over “The knowledge and perspective of our international fellows improves the experience and performance of our the world.” faculty, fellows, and residents here in Southern California,” RAMESH KEKUNNAYA, MD says Anne L. Coleman, MD, PhD, The Fran and Ray Stark Foundation Chair in Ophthalmology. Director, Child Sight Institute “Not only are the international fellows learning from us,” L V Prasad Eye Institute says Dr. Coleman, “but we are also learning from them, Hyderabad, India gaining insight into other cultures and countries in terms of how we can all treat patients with eye diseases, learn ophthalmology, and conduct research. Their presence at UCLA adds to the vibrant, diverse, and inspiring environment that we have here.”

2 UCLA STEIN EYE INSTITUTE | A Year in Review “I chose the Program for the superb faculty, Advancing the fight against blindness for generations the facilities of the Institute, and the The importance of the Department’s International Fellow- reputation of the Program. The knowledge ship Program was underscored in October 2019, when the I acquired, the experience of working at a World Health Organization (WHO) released a new report first-level Institute, and the professional on vision and preventable blindness. relationships that came from my “At present more than 2.2 billion people around the world have a vision impairment, of whom at least 1 billion have involvement have helped me to progress a vision impairment that could have been prevented or is in my own career, and also to guide many yet to be addressed,” states the WHO’s World Report on colleagues in Latin America. Participating in Vision. “The world faces considerable challenges in terms of eye care, including a shortage of trained eye care ser- the Fellowship Program is one of the best vice providers.” decisions I have ever made.” As such, perhaps the most important results produced FRANCISCO J. RODRIGUEZ, MD by the International Fellowship Program are the ophthalmologists worldwide that the Program never sees. Chair, Department of Ophthalmology The Program’s primary mission is to train and build the Universidad del Rosario School of Medicine expertise of the 10 to 20 international fellows who partici- Bogota, Colombia pate each year. And key to that mission is inspiring a sense of commitment among the fellows to pass along their expertise to new generations of ophthalmologists in their own countries and beyond. “Our international fellows elevate the practice of our specialty in their country,” says Robert Alan Goldberg, MD, Bert O. Levy Endowed Chair in Orbital and Ophthalmic Plastic Surgery. “By teaching and practicing at the highest level, they innovate in their fields and become role models in their medical communities.” The influence of the international fellows touches medical care, research, and training throughout the world, as evidenced by the clinics, academic departments, training programs, research teams, and eye care organizations established and nurtured by the Program alumni.

“We work to inspire a sense of responsibility for leadership and innovation that our international fellows can use to train the next generation of ophthalmologists around the world. We achieve our greatest success when our fellows become the innovators in their own countries.”

BARTLY J. MONDINO, MD

Chair, UCLA Department of Ophthalmology Director, Stein Eye Institute

A Year in Review | UCLA STEIN EYE INSTITUTE 3 Year in Review JULY 1, 2019–JUNE 30, 2020 Institute News

New Grants Fund Vital Research Research funding at UCLA from the National Institutes of Health (NIH) is increas- Gabriel H. Travis, MD ing, and the Stein Eye Institute is a significant beneficiary of this support, which is Charles Kenneth Feldman Chair in provided through the National Eye Institute (NEI). Ophthalmology

Seven new NIH grants were awarded in 2019 and total nearly $10 million in fund- Mechanisms for Light-Driven ing.† These grants give an indication of the scope of basic research within Stein Eye Chromophore Synthesis by Müller on key questions affecting the eye. Cells to Regenerate Cone Opsin and Maintain Cone Sensitivity Ava K. Bittner, OD, PhD Anna Matynia, PhD Smotrich Family Optometric Associate Research Ophthalmologist $2,271,848 Clinician-Scientist Chair Molecular, Cellular, Anatomical, Irena Tsui, MD Development of a Behavioral and Neurobiological Investigation Assistant Professor of Ophthalmology Intervention with Socially Assistive of Melanopsin-Expressing Corneal Retinal and Choroidal Vasculature Robots to Enhance Magnification Innervation, and Its Role in Pain Changes in Healthy and High-Risk Device Use for Reading and Photophobia Pregnancies $439,994 $1,950,000 $445,314

Jean-Pierre Hubschman, MD Kouros Nouri-Mahdavi, MD, MSc David S. Williams, PhD Associate Professor of Ophthalmology Associate Professor of Ophthalmology Karl Kirchgessner Foundation Chair in Intraocular Robotic Interventional Detection of Disease Progression in Vision Science and Surgical System for Automated Advanced Glaucoma Exploring the Relationship of Water Cataract Surgery $1,951,500 Flow Across the RPE and Mutant- $2,305,000 MYO7A/Usher 1B † Amounts shown are the total for all years of NIH funding. $429,000

Providing Critical COVID-19 Information to Ophthalmologists

Gary N. Holland, MD, Jack H. Skirball evidence-based clinical guidance on Chair in Ocular Inflammatory Diseases, is topics including ‘how can I protect my working with two other ocular infectious staff and patients,’ ‘what personal protec- disease specialists, James Chodosh, tive equipment do I need,’ ‘how do I dis- MD, MPH, of Harvard University, and infect my office,’ and ‘do antivirals work.’ Steven Yeh, MD, of Emory University, David W. Parke II, MD, chief executive to formulate guidelines for prevention of officer of the AAO, said of this work, “This COVID-19 transmission during eye exam- trio of incredibly talented ophthalmolo- inations and ophthalmic procedures in gist clinician-scientists are the ultimate the midst of the SARS-CoV-2 pandemic professional volunteers who, despite and to provide American Academy of heavy clinical, teaching, and research Ophthalmology (AAO) members with responsibilities, gave up countless hours updated information relevant to the pan- each week and weekend to ensure that demic through its website. the material on the Academy coronavirus web pages was updated at least daily In addition to reflecting changing To help reduce the spread of COVID-19, statistics about the pandemic and to and reflected careful science.” Stein Eye physicians like Dr. Tara McCannel conform to Centers for Disease Con- As of June 30, 2020, the authored (left) and Dr. Niranjan Manoharan (right) wear pages at www.aao.org/headline/alert- protective goggles and gloves during trol (CDC) and other guidelines as they procedures. Rooms and equipment are evolve, the team is answering ques- important-coronavirus-context had been cleaned and disinfected before every patient tions from AAO members seeking viewed over 1.5 million times. examination.

A Year in Review | UCLA STEIN EYE INSTITUTE 5 New Clinic Focused on Treating Dry Eye Persistent and more serious forms of dry eye require focused diagnosis and treatment to maintain the health of your eye, and the new Dry Eye Clinic on the UCLA Stein Eye Institute vision-science campus was developed for this purpose. Dry eye occurs when the glands around the eye cease to produce enough tears to keep the surface of the eye moist. Dry eye can may be associated with aging, diabetes, autoimmune diseases, certain medications, and dry climates. “The UCLA Stein Eye Institute’s Dry Eye Clinic implements a full diagnostic workup looking at all the different parts of the ocular surface that can contribute to dry eye, and then we tailor a specialized treatment focused on each patient’s individual needs” says Vivian Shibayama, OD, clinical instructor in ophthalmology, who runs the clinic with Saba Al-Hashimi, MD, health sciences assistant clinical professor of ophthalmology. The clinic also offers in-office procedures not typically available at eye centers, such as BlephEx, LipiFlow, intense pulsed light therapy, scleral lenses, saline-filled contact lenses, amniotic membrane therapy, and autologous serum tears. To make an appointment at the UCLA Stein Eye Institute Dry Eye Clinic, call: (310) 206-6351.

6 UCLA STEIN EYE INSTITUTE | A Year in Review Awards and Honors

2019 AAO ANNUAL MEETING Sophie X. Deng, MD, PhD, Joan and Faculty Awards and Honors Jerome Snyder Chair in Cornea Dis- Anthony J. Aldave, MD, Walton Li Chair American Academy of eases, served as program director for in Cornea and Uveitis, presented the Ophthalmology Awards the AAO Subspecialty Day: Cornea. 32nd Annual Bajandas Guest Lecture Congratulations to UCLA Department of (virtual connection) in San Antonio, Ophthalmology faculty and alumni who JoAnn A. Giaconi, MD, health sciences Texas, on April 25, 2020. were recognized for their leadership at associate clinical professor of ophthal- the October 12–15, 2019, American Acad- mology, served as program director for emy of Ophthalmology (AAO) annual Anthony C. Arnold, MD, Mary Oakley the AAO Subspecialty Day: Glaucoma. meeting in San Francisco, California. Foundation Chair in Neurodegenera- tive Diseases, was the chair/convener LIFE ACHIEVEMENT HONOR AWARD Lynn K. Gordon, MD, PhD, Vernon (virtual connection) for the Neuro- Don O. Kikkawa, MD, alumnus O. Underwood Family Chair in Oph- Ophthalmology Program of the World thalmology, was recognized at the Ophthalmology Congress held June SENIOR ACHIEVEMENT AWARD AAO opening ceremony by David W. 26–29, 2020. Simon K. Law, MD, PharmD, faculty Parke II, MD, chief executive officer of the AAO. Dr. Parke noted that Todd P. Margolis, MD, PhD, alumnus Ava K. Bittner, OD, PhD, Smotrich Dr. Gordon was finishing her term as Alfred M. Solish, MD, alumnus Family Optometric Clinician-Scientist chair of the AAO Council in Decem- Chair, received the 2019 Clinical ber 2019, and he thanked Dr. Gordon ACHIEVEMENT AWARD Research Award for $100,000 from the for her distinguished service and American Academy of Optometry and Michael B. Gorin, MD, PhD, faculty for her leadership and dedication to a sub-award from the National Institute David A. Hollander, MD, alumnus the Council. David K. Isaacs, MD, alumnus on Disability, Independent Living, and Rehabilitation Research to conduct the John T. Mandeville, MD, PhD, alumnus Kevin M. Miller, MD, Kolokotrones “Community Access through Remote Scott C. Oliver, MD, alumnus Chair in Ophthalmology, presented the Eyesight (CARE) Study” of Aira ser- Ehsan Rahimy, MD, alumnus Charles D. Kelman Lecture on “Artificial vices for people who are blind or have Tina Rutar, MD, alumnus Iris Implantation” on October 14, 2019. low vision. SECRETARIAT AWARD In addition, Dr. Bittner served as the Simon K. Law, MD, faculty Peter A. Quiros, MD, health sci- co-chair for the NIH/NEI strategic plan Kouros Nouri-Mahdavi, MD, faculty ences associate clinical professor of panel, 2020 Vision for the Future: Individual Quality of Life, in April 2020. SriniVas R. Sadda, MD, faculty ophthalmology, served as program director for the AAO Subspecialty Day: Neuro-Ophthalmology. Faculty Honors Joseph Caprioli, MD, David May II 2019 AAO Annual Meeting Chair in Ophthalmology, gave the SriniVas R. Sadda, MD, professor of Frontiers in Vision Science Lecture, Anthony J. Aldave, MD, Walton Li Chair ophthalmology, served as a member “Compartmental Retinal Ganglion in Cornea and Uveitis, presented the of the planning group for the AAO Sub- Cell Damage and Recovery in Glau- Dr. Allan Jensen and Claire Jensen specialty Day: Retina. coma,” at the Bascom Palmer Eye Lecture in Professionalism and Ethics Institute in Miami, Florida, on January titled “Ethical Aspects of Global Oph- 23, 2020. thalmic Practice” on October 14, 2019. Edmund Tsui, MD, assistant professor, was awarded Best Original Paper (Uveitis) for “One-Year Outcomes of Anne L. Coleman, MD, PhD, The Uveitic Macular Edema in the First-Line Fran and Ray Stark Foundation Chair Antimetabolites as Steroid-Sparing in Ophthalmology, was inducted Treatment (FAST) Uveitis Trial” on as president-elect of the American October 14, 2019. Academy of Ophthalmology and presented the Academy President-Elect’s Address at the AAO opening ceremony on October 13, 2019.

A Year in Review | UCLA STEIN EYE INSTITUTE 7 Anne L. Coleman, MD, PhD, The Fran Lynn K. Gordon, MD, PhD, Vernon O. Steven D. Schwartz, MD, The Ahman- and Ray Stark Foundation Chair in Underwood Family Chair in Ophthal- son Chair in Ophthalmology, and Ophthalmology, and member of the mology, and Women in Ophthalmol- scientists at the UCLA Eli and Edythe Association for Research in Vision and ogy Champion for Change awardee, Broad Center of Regenerative Med- Ophthalmology (ARVO) Gold Fellow received the 2019 Distinguished Ser- icine and Stem Cell Research, have Class of 2019, was honored with the vice Award from the California Acad- been awarded a $5.1 million grant from designation of FARVO at the 2019 emy of Eye Physicians and Surgeons. the California Institute for Regenerative ARVO Meeting on April 28, 2019, in Medicine to advance the development Vancouver, Canada. of a novel therapy for blinding retinal Jean-Pierre Hubschman, MD, associ- conditions. In addition, Dr. Coleman received the ate professor of ophthalmology, and Bonnie Strickland Champion for Chil- his colleagues were announced as dren’s Vision Award from the National winners of the UCLA Innovation Fund Gabriel H. Travis, MD, Charles Kenneth Center for Children’s Vision and Eye for their Intraocular Robotic Interven- Feldman Chair in Ophthalmology, pre- Health (NCCVEH) at Prevent Blind- tional Surgical System (IRISS) for Cata- sented the Annual Futterman Memorial ness at the NCCVEH Annual Meeting ract in February 2020. Kairos Ventures Lecture, “Light Driven Regeneration of on September 14, 2019, in Baltimore, also awarded the team a $100,000 gift Cone Visual Pigments,” at the Univer- Maryland. to support the IRISS research, in rec- sity of Washington School of Medicine ognition that the technology has the in Seattle, Washington, on January 16, Dr. Coleman also presented The potential to improve the quality of peo- 2020. Joseph Smiddy Memorial Lecture, ple’s lives. The team also received two “Looking Beyond Established Risk R01 grants from the National Institutes Factors: Lifestyle and Nutrition in Glau- Edmund Tsui, MD, assistant professor of Health to support this research. coma,” at the Wilmer Eye Institute at of ophthalmology, received a $70,000 Johns Hopkins University on Decem- Career Starter Grant from the Knights ber 5, 2019, in Baltimore, Maryland. Roxana A. Radu, MD, assistant profes- Templar Eye Foundation on April 7, sor of ophthalmology, was awarded a 2020, to study quantitative imaging $125,000 Rose Hills Foundation (RHF) biomarkers in pediatric anterior uveitis. Sophie X. Deng, MD, PhD, Joan Research award from the Broad Stem and Jerome Snyder Chair in Cornea Cell Research Center for her project Diseases, received a four-year $10.3 Barry A. Weissman, OD, PhD, profes- “The Role of ABCA4 in iPSC-derived million award from the California Insti- sor of ophthalmology emeritus, was RPE Cells from Patients with Macular tute for Regenerative Medicine, which presented with the 2019 Dr. Richard Degeneration.” The RHF award sup- will fund a clinical trial for limbal stem Hemenger Faculty Research Award ports innovative science conducted cell deficiency. at the Marshall B. Ketchum University by UCLA’s junior faculty that will (MBKU) Southern California College advance the understanding and utility of Optometry Fall Awards ceremony Brian A. Francis, MD, MS, Rupert and of stem cells. on November 12, 2019, in Fullerton, Gertrude I. Stieger Vision Research California. Chair, delivered the Surgery Day Lec- ture, “How to Evolve with Glaucoma,” at the American Glaucoma Society annual meeting in Washington, DC, on February 27, 2020.

JoAnn A. Giaconi, MD, health sciences clinical professor of ophthalmology, was the recipient of the AUPO/AAO Excellence in Medical Student Edu- cation Award at the Association of University Professors of Ophthalmol- ogy annual meeting in Rancho Mirage, Dr. JoAnn Giaconi (right), shown with AUPO California, on January 30, 2020. President Dr. Paul Sternberg, Jr., is recognized for her teaching excellence.

8 UCLA STEIN EYE INSTITUTE | A Year in Review Milestones

Faculty Appointments Stein Eye and Doheny Eye Institutes The 2019–2020 Academic Year wel- comed new faculty to the UCLA Depart- Celebrate Five Years of Partnership ment of Ophthalmology. For detailed Alumni from the Stein and Doheny Eye Institutes gathered for a reception on information about each faculty mem- October 13, 2019, in San Francisco, California, and marked a five-year milestone. ber, please refer to the Faculty and Col- In 2014, the Doheny Eye Institute began its historic partnership with the UCLA leagues section of this Annual Report. Department of Ophthalmology. With that action, UCLA became the only univer- Laura Bonelli, MD sity in the United States with two eye institutes: the Stein Eye Institute and the Health Sciences Assistant Doheny Eye Institute. Clinical Professor In his speech to attendees, Bartly J. Mondino, MD, chair of the UCLA Depart- ment of Ophthalmology and affiliation chair for the Doheny Eye Institute, reflected Kaustabh Ghosh, PhD on the brave leap of faith required by the USC faculty who were coming to a Associate Professor new home: “I told the USC faculty they would be on the ground floor in estab- Monica R. Khitri lishing something great—this unprecedented and perhaps unique affiliation in MD, Health Sciences Assistant ophthalmology.” Clinical Professor Trust in that promised outcome was justified. Doheny’s partnership with UCLA has proven to be a bona fide success. Over 20 faculty have been recruited as Shawn R. Lin, MD a result of the affiliation, and between the two Institutes, there are 35 endowed Health Sciences Assistant chairs and more than 30 fellows. Doheny Eye Centers UCLA in Arcadia, Orange Clinical Professor County, and Pasadena are operational, with strong upward trajectories in new visits, return visits, and surgeries. Just as importantly, the three Centers have Yirong Peng, PhD returned a profit, which is noteworthy for medical centers with senior faculty, Assistant Professor of Ophthalmology broad research, federal grants, and educational activities. Edmund Tsui, MD Looking forward, the Doheny Eye Institute has purchased a state-of-the-art Assistant Professor facility in Pasadena, with generous grounds for parking and future expansion. The building will include research labs, as well as educational and patient care facilities. The Doheny Eye Institute in “Eastwood” will be home to the UCLA Department of Ophthalmology’s second vision-science campus, complementing the Stein Eye Institute’s vision-science campus in Westwood, which was completed in 2017, with the construction of the Edie & Lew Wasserman Building and renovation and seismic upgrade of the Jules Stein Building. “Aside from the historic and remarkable affiliation,” said Alfredo A. Sadun, MD, PhD, vice chair of ophthalmology at the Doheny Eye Center UCLA, “I person- ally feel extremely gratified that the large core of former faculty, who, by voting with their feet demonstrated great courage in leaving USC, can now look back, The Doheny Eye Institute vision-science campus in Pasadena, anticipated opening five years after, knowing that their faith in UCLA, in our leadership, and in each 2021. other, was fully justified.”

A Year in Review | UCLA STEIN EYE INSTITUTE 9 Education

Resident and Fellow Research Fellow Research Award Fellowship Faculty Teaching Award Graduation and Award Vahid Mohammadzadeh, MD Jean-Pierre Hubschman, MD Ceremony Postdoctoral Fellow Fellow Teaching Award Residents, fellows, and faculty were hon- Research Award Niranjan Manoharan, MD ored for excellence at the UCLA Depart- Wenlin Zhang, MD, PhD ment of Ophthalmology graduation on Resident Teaching Award June 17, 2020. Due to COVID-19, the Predoctoral Fellow William “Wade” Stoddard ceremony was held virtually to ensure Research Award the safety of all attendees. Adrian Au, MD Resident Award for Medical Resident and Fellow Awards Student Teaching Teaching Awards Nick Iafe, MD Resident Research Award Faculty Teaching Award Tamara Lenis Resident Weekly Quiz Award Hamid Hosseini Lynn Shi, MD Clinical Fellow Research Award Victoria Tseng, MD, PhD

25th Vision-Science Conference The annual Vision-Science Conference, jointly sponsored by the UCLA Stein Eye Best Oral Presentations Institute and the National Eye Institute Vision Science Training Grant, celebrated its Norianne Ingram, PhD twenty-fifth year October 11–13, 2019, at the UCLA Lake Arrowhead Conference Center. Joseph Park Eighty participants—including basic scientists, clinical researchers, pre- and post- Michel Sun, MD, PhD doctoral fellows, and invited guests—participated in discussions and educational activities. Greg Field, PhD, assistant professor of neurobiology, Duke University School Best Poster Presentations of Medicine, presented the keynote address “New insights into parallel processing Nan Hultgren, PhD and synchronous activity in the mammalian retina.” Benjamin Smith, PhD Awards were presented for best oral presentations and best posters. Jeonghyun Johnny Ji

10 UCLA STEIN EYE INSTITUTE | A Year in Review Training in Cataract Surgery To help meet the demand for surgery to treat cataracts, the Basic Cataract Surgery Course—a module of the UCLA Department of Ophthalmology’s Comprehensive Cataract Surgery Pro- gram—was held November 2019 in Irvine, California. Sponsored by Bausch & Lomb, the course includes all the steps of cataract surgery from incision construction through postoperative instructions. Skills-transfer laboratories provided attendees with hands-on experience in phacoemulsification, phacodynamics, ocular biometry, corneal topography, intraocular lens power calculation, capsulorrhexis, ophthalmic viscosurgical devices, lens loading, toric lens implantation, and laser capsulotomy. The April 4, 2020, Advanced Cataract Surgery Course—sponsored by Alcon Laboratories—was cancelled due to COVID-19. Dr. Daniel Rootman instructs attendees at the Orbital Surgery Master’s For information about upcoming cataract surgery courses, Symposium and Dissection Workshop. contact Kevin M. Miller, MD, Kolokotrones Chair in Ophthalmol- ogy and chief of the Cataract and Refractive Surgery Division, Orbital Surgery Master’s Symposium and at [email protected]. Dissection Workshop Surgical specialists and practicing ophthalmologists from four continents participated in the UCLA Orbital Surgery Master’s Symposium and Dissection Workshop on March 3–4, 2020, at the Stein Eye Institute vision-science campus in Westwood. The event focuses on practical techniques and conceptual pearls that participants can immediately apply to their own practice. Educational lectures included presentation of the Jack Rootman Lectureship in Orbital Disease by Gerald Harris, MD, chief of the Orbital and Oculoplastic Surgery Eye Institute at the Medical College of Wisconsin. The biennial program was chaired by Robert Alan Goldberg, MD, Bert O. Levy Endowed Chair in Orbital and Ophthalmic Plastic Surgery and chief of the Orbital and Ophthalmic Plastic Surgery Division, and Daniel B. Rootman, MD, MS, Karen and Frank Dabby Endowed Chair in Ophthalmology.

Annual Comprehensive Ophthalmology Review Course The UCLA Stein Eye Institute and the Doheny Eye Institute presented the Annual Comprehensive Ophthalmology Review Course on February 20–23, 2020, at the Stein Eye Institute vision-science campus in Westwood. Attendees at the 2019 Basic Cataract Surgery Course gain The intensive four-day course reviewed the clinical essen- hands-on surgical experience. tials of each subspecialty in ophthalmology, and prepared the attendees for upcoming ophthalmology examinations and required continuing medical education recertification. Instruc- tion concentrated on the epidemiology, clinical presentation, diagnosis, and management of ophthalmologic disease. Directed by John A. Irvine, MD, and Mitra Nejad, MD, the 2020 course included contributions from guest faculty.

A Year in Review | UCLA STEIN EYE INSTITUTE 11 Community Outreach

From July 1, 2019 to June 30, 2020, the UCLA Mobile Eye Clinic (UMEC) collab- orated with influential organizations, including the Los Angeles Dodgers, with whom they attended eight events and served over 170 patients. Based on these successful interactions, UMEC will be returning to Los Angeles Dodgers events in spring and summer 2021 to continue performing eye health screenings for underserved and undertreated Angelenos. Continuing to find ways to increase accessibility to vision care, UMEC part- nered in November 2019 with Care Harbor, a mega-clinic that focuses on grassroots health care solutions and has served over 26,000 patients in the last 10 years. At Care Harbor, UMEC’s UCLA HEALTH IS DODGER BLUE! team addressed the needs of patients As part of the partnership between UCLA Health and the Los Angeles Dodgers, the UCLA Mobile who had pre-existing eye health condi- Eye Clinic provides vision care at home games. (L to R): UCLA leadership, Dr. John Mazziotta, tions, including diabetes and high blood Dr. Robert Cherry, and Johnese Spisso (far right) with Dodgers’ Manager, Dave Roberts. pressure, to provide them with further examinations and referrals to specialists as needed. At the three-day event, UMEC also continued its preschool resumed community outreach on August UMEC’s diverse staff of multilingual oph- vision program during the 2019–2020 17, 2020. Personal protective equipment thalmologists, ophthalmic technicians, school year: 5,897 preschoolers were and cleaning supplies were secured to volunteers, and interns provided care screened, 433 received eye exams, keep patients, faculty, and staff safe. for 262 patients with 105 referrals for and 407 eyeglasses were provided to Find out more about the UCLA Mobile follow-up care. underserved preschool children in low- Eye Clinic at: www.uclahealth.org/umec. During the holiday season, doctors, income communities in Los Angeles. technicians, and staff from the Stein Eye UMEC referred 134 preschoolers to part- and Doheny Eye Institutes—along with ner specialists for further specialized volunteers—provided eye health screen- medical or surgical treatments. ings at the Westside Thanksgiving Dinner Since fall 2019, UMEC has had eight and Celebration, an event that provides medical students from UCLA and other free medical, dental, and vision services. national and international universities UMEC also participated in the Compre- assist with research projects. The med- hensive Community Health Centers Holi- ical students also assisted with provid- day Health Fair in December, which helps ing free vision care and shadowed the individuals learn about health resources ophthalmologists on the UMEC. The available to them. Ophthalmologists, UMEC also had 39 UCLA undergradu- staff, medical students, and volunteers ate interns and volunteers that assisted also provided eye health screenings and UMEC with several aspects of the orga- reading glasses. In January 2020, UMEC nization, including fundraising. Eleven participated in the 6th Annual Skid Row of the undergraduate interns and volun- Carnival of Love where approximately teers applied for medical school or other 800 individuals experiencing home- professional programs after graduation. lessness received a health screening Because of the COVID-19 pandemic, and referral for follow-up from one of the the Stein Eye Institute suspended all many medical providers at the event. Eye community outreach operations in March health screenings and reading glasses 2020. Following approval from the UCLA were provided. COVID-19 Command Center, UMEC

12 UCLA STEIN EYE INSTITUTE | A Year in Review Alumni News

Paul S. Bernstein, MD, PhD UCLA Stein Eye Institute (Residency class of ’93, Fellowship Alumni Association class of ’93, and 2004 Bradley R. Support Group Straatsma Lecturer) was given the Association for Research in Vision New officers were appointed to the and Ophthalmology 2020 Mildred UCLA Stein Eye Institute Alumni Asso- Weisenfeld Award for Excellence in ciation in 2019—faculty alumna Dr. J. Ophthalmology. Bronwyn Bateman, President (Residency class of ’78, Fellowship class of ’79); Dr. Troy Elander, Vice President, assistant Jerrold C. Bocci, MD, FACS clinical professor in the UCLA Depart- (Residency class of ’66) passed away ment of Ophthalmology, who has been from complications of glioblastoma on part of the volunteer teaching faculty for January 9, 2020. nearly 30 years; and Associate Profes- sor of Ophthalmology and Residency Program Director Dr. Stacy Pineles, John So-Min Chang, MD J. Bronwyn Bateman, MD, PhD Secretary/Treasurer (Residency class (Residency class of ’90) received the President of ’08, Fellowship class of ’09). International Society of Refractive The Alumni Association also became Surgery (ISRS) Founders’ Award on an officially recognized UCLA Support October 11, 2019, in San Francisco, Group, with the primary objectives to California. promote the social and professional rela- tions of its members and alumni as well David B. Glasser, MD as advance the interests of Stein Eye and (Residency class of ’83 and 2009 the Department of Ophthalmology. Stein Thomas H. Pettit Lecturer), American Eye is the common bond, and as such, Academy of Ophthalmology Secretary membership is open to all graduates, for Federal Affairs, participated in a residents, fellows, faculty, and volunteer congressional roundtable hosted by clinical faculty. Annual membership dues the Congressional Vision Caucus, the are nominal and help underwrite the Res- Global Coalition on Aging, and Prevent ident Research Grant Awards, the Stein Stacy L. Pineles, MD Blindness. Eye Institute Excellence in Research Secretary/Treasurer Graduation Awards for Residents and Fellows, and the annual receptions at the Barry M. Kerman, MD American Academy of Ophthalmology (Residency class of ’74 and Fellow- and Association for Research in Vision ship class of ’75) was voted the 2019 and Ophthalmology. “Teacher of the Year” for the California To become a member of the UCLA Pacific Medical Center–San Francisco Stein Eye Institute Alumni Association, campus. go to: giving.ucla.edu/SEIAlumniDues.

Gregg T. Kokame, MD (Residency class of ’87 and 2013 Thomas H. Pettit Lecturer) was appointed chief of the Division of Troy Elander, MD Ophthalmology at the University of Vice President Hawaii School of Medicine starting January 1, 2020.

A Year in Review | UCLA STEIN EYE INSTITUTE 13 2019 Stein and Doheny Alumni Reception

Alumni from the Stein and Doheny Eye Institutes attended a reception in San Francisco, California, on October 13, 2019. The joint reception—held annually during the American Academy of Oph- thalmology meeting—was hosted by the UCLA Stein Eye Institute Alumni Association and the Doheny Eye Institute Professional Alumni Association.

Drs. John Chang and J. Bronwyn Bateman share a commitment to advancing their field and serve as leaders in ophthalmology societies. Dr. Bartly Mondino (center), chair of the UCLA Department of Ophthalmology and director of the Stein Eye Institute, with Department faculty members Dr. Anne Coleman (left), president-elect of the American Academy of Ophthalmology, and Dr. Lynn Gordon, immediate past chair of the AAO Council.

L to r: Isabela Lin, Dr. Tara McCannel, Dr. Shawn Lin, and Dr. Mitra Nejad enjoy the evening festivities. UCLA Department of Ophthalmology faculty members (l to r): Drs. Simon Law, James Tan, and Kouros Nouri-Mahdavi.

14 UCLA STEIN EYE INSTITUTE | A Year in Review L to r: Dr. Alfredo Sadun, vice chair of ophthalmology, Doheny Eye Center UCLA, with Dr. SriniVas Sadda, president and chief scientific officer, Doheny Eye Institute.

Dr. J Bronwyn Bateman (left) and Dr. Bartly Mondino with Ms. Marissa Goldberg (right), executive director and chief financial officer of the Doheny Eye Institute.

Dr. Joseph Demer (left) joins his colleague and research collaborator Dr. Azam Qureshi.

L to r: Drs. Lydia Sauer, Paul Bernstein, Bradley Straatsma, and Andrew Chang savor the chance to reconnect at the alumni event.

Drs. George Rajacich (left) and Troy Elander enjoy an opportunity to visit with one another.

A Year in Review | UCLA STEIN EYE INSTITUTE 15 The End of an Era

Dr. Bartly Mondino (left) is shown with Dr. Dean Bok, whose renowned work has advanced our knowledge of the eye and has contributed to the prevention of blindness.

Celebrating the Work of Dr. Dean Bok Colleagues, friends, and family honored Dean Bok, PhD, the Dolly Green Chair of tenure of his career and was instrumental Ophthalmology, professor of ophthalmology emeritus, and distinguished research in the NEI program planning for “Vision professor of neurobiology, at a retirement reception on March 11, 2020, at the UCLA Research–A National Plan: 1998–2003.” Stein Eye Institute vision-science campus. Dr. Bok has authored approximately 150 Speaking to the gathered attendees, Bartly J. Mondino, MD, chair of the UCLA publications and 25 book chapters. Department of Ophthalmology and director of the Stein Eye Institute, said, “Dr. Bok His decades of awards and honors is revered in vision science. He has been an extremely productive scientist and include the Paul Kayser International teacher, stalwart Departmental citizen, and formidable resource for mentoring in the Award in Retina Research from the Retina Vision Science Division at UCLA. His scientific standing is matched by his personal Research Foundation, the Llura Liggett characteristics of integrity, fairness, and loyalty.” Gund Lifetime Achievement Award from The primary focus of Dr. Bok’s research has been the study of the interaction of the Foundation Fighting Blindness, and photoreceptor cells with the retinal pigment epithelium in health and disease. His the Helen Keller Prize for Vision Research renowned scientific work has advanced our knowledge of the eye and has contrib- from the Helen Keller Foundation. uted to the prevention of blindness. One of Dr. Bok’s greatest contribu- After thanking Dr. Mondino for his leadership of the Institute, Dr. Bok reflected tions to scientific discovery has been his on his 51 years as a member of Stein Eye and noted other Department colleagues mentorship of young investigators. Dr. who greatly influenced his career. “My mentor in the Department of Anatomy (now Bok’s ability to inspire future research- Neurobiology) was Dr. Richard Young, whose seminal work on retinal photoreceptor ers has been recognized with teaching cell biology had an impact that reverberates within the field of vision science to this awards throughout his career, including day. Notable also was the presence of founding members of the Institute on my doc- Professor of the Year, Professor Most toral committee, Drs. Michael Hall, Thomas Pettit, and Bradley Straatsma. From that Deserving of Commendation, Best Lec- time forward, Dr. Straatsma, founding chair of the Department and founding director turer, Best Academic Course, and Dis- of the Institute, has been one of my strongest supporters.” Dr. Bok also recognized tinguished Teaching Awards from the three members of his technical staff—Marcia Lloyd, Jane Hu, and Alberto Ruiz—who UCLA School of Dentistry and the UCLA he said, “made my experience in the laboratory gratifying and productive.” Alumni Association. In addition to his research, Dr. Bok has served on scientific advisory boards of Capturing the emotion felt by all who prestigious companies, foundations, and medical institutions. He is on the Board of were gathered, Dr. Mondino summed Directors of the Macular Vision Research Foundation, and he has received substantial up the impact of Dr. Bok’s retirement: “It funding from the National Eye Institute (NEI) and numerous foundations for the entire is the end of an era here at Stein Eye.”

16 UCLA STEIN EYE INSTITUTE | A Year in Review Philanthropy New Chair Appointments

Congratulations to UCLA Department of Ophthalmology faculty on being honored with prestigious chair appointments. Suraj P. Bhat, PhD, professor of ophthalmology, has been appointed Oppenheimer Brothers Chair. The chair, established in 2002, supports the research and education activities of an outstanding scientist to advance basic research in vision at the UCLA Stein Eye Institute. Sophie X. Deng, MD, PhD, professor of ophthalmology, has been selected as the Joan and Jerome Snyder Chair in Cornea Diseases. The chair was established in 2013 by Mr. and Mrs. Snyder and supports the activities of a distinguished faculty member in the area of corneal diseases and research. Daniel B. Rootman, MD, assistant professor of ophthalmology, has been chosen as the Karen and Frank Dabby Endowed Chair in Ophthalmology. The chair, established in 2007, supports the activities of a distinguished faculty member in the area of orbital disease. David S. Williams, PhD, professor of ophthalmology and neurobiology, has been appointed Karl Kirchgessner Foundation Chair in Vision Science. This chair was established in 2001 to support pioneering vision research at the UCLA Stein Eye Institute. Chairs pay tribute to both the faculty member who holds the chair appointment and the chair’s donor. “We are indebted and gratified by our supporters’ tremendous commitment to and belief in the Stein Eye Institute and the work we do,” says Bartly J. Mondino, MD, director of the Stein Eye Institute, chair of the UCLA Department of Ophthalmology, and affiliation chair of the Doheny Eye Institute.

Suraj P. Bhat, PhD Sophie X. Deng, MD, PhD Oppenheimer Brothers Chair Joan and Jerome Snyder Chair in Cornea Diseases

Daniel B. Rootman, MD David S. Williams, PhD Karen and Frank Dabby Endowed Chair Karl Kirchgessner Foundation Chair in Ophthalmology in Vision Science

18 UCLA STEIN EYE INSTITUTE | Philanthropy With Thanks

or more than half a century, countless loyal friends and donors have generously contributed to uphold the mission of the UCLA FStein Eye Institute in the noble effort to preserve sight and restore vision. This dedication has had an invaluable impact on ophthalmology and related dis- ciplines locally, nationally, and abroad. We embrace the future strides we—and the next generation of eye specialists and vital supporters—will make to advance this meaningful and influential medical and scientific field.

Donations July 1, 2019–June 30, 2020

Major Gifts $25,000 and Above: Richard B. Shapiro Kevin M. Miller, MD Anonymous Robert Morell Carmichael L. Scott Feiler, MD Anthony Eanelli Estate Scripps Clinic & Research Foundation Laura E. Fox, MD Aramont Foundation The Foundation Fighting Blindness Leiloni Breidert Bert O. Levy The Nicholas Endowment Lynn K. Gordon, MD, PhD Bradley R. Straatsma, MD, JD The Simms/Mann Family Foundation Mark Landig, OD Bruce Ford and Anne Smith Bundy The Vision of Children Foundation, Michael B. Gorin, MD, PhD Foundation Sam and Vivian Hardage Patricia Tussing Choroideremia Research Foundation The William & Margaret Fern Holmes Robert E. Engstrom, Jr., MD Family Foundation Elaine Sarkaria, EdD Robert S. Hepler, MD United Mitochondrial Disease Estate of Jean Stein Steven D. Schwartz, MD Foundation Estate of Katharine L. Gardner Tara A. McCannel, MD, PhD VHL Family Alliance Estate of Miles H. Mallory Woodmere Foundation IN MEMORY OF: Fidelity Charitable Tom and Jessica Daljit S. Sarkaria Rothman Charitable Fund Individuals Recognized David J. Gray Goldman Sachs Philanthropy Fund with a Tribute Gift Hannemann Family Fund Donald M. Fetherolf Heidelberg Engineering GmbH IN HONOR OF: Duane Carter Hilel Lewis, MD Abby North Genevene Vogel Hongbin Peng Andrew Chen, MD Harold Shapiro J. Bronwyn Bateman, MD Anthony J. Aldave, MD Herbert J. Grossman, MD Joan A. Payden and William R. Payden Bartly J. Mondino, MD Jerome H. Snyder Julie Kavner Bradley R. Straatsma, MD, JD Jerrold C. Bocci, MD Kairos Ventures Partners II, L.P. Ellen Shipley Judy Page Kelvin L. Davis Gail Summers Katherine L. Gray Knights Templar Eye Foundation, Inc. Gary N. Holland, MD Mr. and Mrs. M. Gorman Lavery Foundation Howard R. Krauss, MD Robert Cottle Peter J. Nolan and Stephanie J. Nolan Jeffrey Wong, PhD, and Family Robert Darfield Terrell Research to Prevent Blindness, Inc. John D. Bartlett, MD Ruth Straatsma (Research to Prevent Blindness Joseph Caprioli, MD Stephen Seiff, MD Endowment Fund) Joseph L. Demer, MD, PhD Victoria Szuflita Resnick Foundation Kathryn M. Gardner, MD

Philanthropy | UCLA STEIN EYE INSTITUTE 19 Stein Eye Institute Endowed David May II Chair in Ophthalmology Hilel Lewis Family Chair in Chairs Supporting Department Established in 1998 as a term- Ophthalmology of Ophthalmology Faculty appointment chair by the family of Established at UCLA in 2020 in Mr. David May II, a founding member collaboration with Dr. Hilel Lewis via Arthur L. Rosenbaum, MD, Chair in of the Institute’s Board of Trustees, to Columbia University to support an Pediatric Ophthalmology perpetuate, in memoriam, Mr. May’s outstanding clinician-investigator in retina. Established in 2007 by Mr. and association with the Stein Eye Mrs. Gottlieb as an administrative Institute; after an additional pledge from the Wilbur May Foundation, Jack H. Skirball Chair in Ocular chair for the Division of Pediatric Inflammatory Diseases Ophthalmology and Strabismus it was converted to a permanent- Initiated in 2008 by The Skirball in honor of the late Dr. Arthur L. appointment chair in 2009. Foundation in honor of Mr. Jack H. Rosenbaum. The chair was originally Gary N. Holland, MD Skirball’s long-standing friendship named the Brindell and Milton Gottlieb 1999–2004 with Dr. Jules Stein and Mr. Lew Chair in Pediatric Ophthalmology. Joseph Caprioli, MD Wasserman. Arthur L. Rosenbaum, MD 2004–Present Gary N. Holland, MD 2008–June 2010 Dolly Green Chair of Ophthalmology 2009–Present Joseph L. Demer, MD, PhD 2015–Present Established in 1980 by Ms. Dorothy Jerome and Joan Snyder Chair in (Dolly) Green. Ophthalmology Bert O. Levy Endowed Chair in Orbital Dean Bok, PhD Established in 2008 by Mr. and Mrs. and Ophthalmic Plastic Surgery 1984–2013 Snyder to support the activities of a Established in 2019 as a permanent- distinguished faculty member who appointment chair by Mr. Bert Levy Ernest G. Herman Chair in directs the ophthalmology residency to support the teaching and research Ophthalmology program, ensuring that UCLA’s activities of an outstanding, academic Established in 2008 by Mr. Ernest G. accredited program continues to orbital and ophthalmic plastic surgeon. Herman to support a vision scientist or offer rigorous and comprehensive Robert A. Goldberg, MD a clinician-investigator. instruction for individuals of the highest caliber. 2019–Present Xian-Jie Yang, PhD 2012–Present Anthony C. Arnold, MD Bradley R. Straatsma, MD, Endowed 2008–2017 Chair in Ophthalmology Grace and Walter Lantz Endowed Stacy L. Pineles, MD Established in 1994 to honor founding Chair in Ophthalmology 2017–Present director of the Stein Eye Institute, Established in 1991 as a term- Bradley R. Straatsma, MD, JD. appointment chair by Mr. and Mrs. Joan and Jerome Snyder Chair in Bartly J. Mondino, MD Lantz and, with an additional pledge, Cornea Diseases it was converted to a permanent- 2000–Present Established in 2013 by Mr. and Mrs. appointment chair in 2010. Snyder to support the activities of a Charles Kenneth Feldman Chair in J. Bronwyn Bateman, MD distinguished faculty member in the Ophthalmology Grace and Walter Lantz Scholar area of corneal diseases and research. Established in 1982 by various donors 1993–1995 Sophie X. Deng, MD, PhD in memory of Charles Kenneth Sherwin J. Isenberg, MD 2019–Present Feldman, an entertainment industry Grace and Walter Lantz Scholar executive. 1993–1995 Joan and Jerome Snyder Chair in Robert D. Yee, MD Professor 1996–2004 Vision Science Professor 1984–1987 Established In 2018, this term chair Joseph L. Demer, MD, PhD will support the teaching and research Hilel Lewis, MD Professor 2004–2005 Scholar 1989–1993 activities of an excellent scientist Harold and Pauline Price Chair in and faculty member in the Vision- Gabriel H. Travis, MD Ophthalmology Science Division. 2001–Present Established in 2000 by the Louis and Harold Price Foundation and, with an additional pledge, it was converted to a permanent-appointment chair in 2006. Michael B. Gorin, MD, PhD 2006–Present

20 UCLA STEIN EYE INSTITUTE | Philanthropy Jules Stein Chair in Ophthalmology Leonard Apt Endowed Chair in The Fran and Ray Stark Foundation Established in 1982 as a memorial Pediatric Ophthalmology Chair in Ophthalmology tribute to Dr. Jules Stein by his Established in 2004 by Professor Established in 1992 as a term- many friends, with the leadership of Emeritus of Ophthalmology and appointment chair by the Fran Mr. Samuel Goldwyn, Jr. Founding Director of the Division and Ray Stark Foundation, and of Pediatric Ophthalmology and with an additional commitment, it Wayne L. Hubbell, PhD Strabismus, Dr. Leonard Apt, with was converted to a permanent- 1983–Present a gift from the trust of Frederic G. appointment chair in 2009. Rappaport, Dr. Apt’s nephew. Karen and Frank Dabby Endowed Joseph Caprioli, MD Chair in Ophthalmology Joseph L. Demer, MD, PhD 1997–2004 Established in 2007 by Dr. and Mrs. 2005–2015 Anne L. Coleman, MD, PhD Dabby as a term chair to support the 2004–Present activities of a distinguished faculty Mary Oakley Foundation Chair in Neurodegenerative Diseases member in the area of orbital disease. The Wasserman Professor of Established in 2013 by The Mary Robert Alan Goldberg, MD Ophthalmology Oakley Foundation to support 2008–2018 Established in 1977 by Edie and Lew neurodegenerative diseases. Wasserman to honor Dr. Jules Stein. Daniel B. Rootman, MD, MS Anthony C. Arnold, MD 2019–Present Manfred Spitznas, MD 2017–Present 1979–1981 Karl Kirchgessner Foundation Chair in Oppenheimer Brothers Chair Vision Science Bartly J. Mondino, MD Established in 2002 as a term chair Scholar 1984–1988 Established in 2001 as a term- by the Oppenheimer Brothers Professor 1988–2000 appointment chair by a colleague Foundation. of Dr. Jules Stein to promote basic- Ben J. Glasgow, MD science research initiatives. Joseph Horwitz, PhD 2003–Present 2003–2017 Debora B. Farber, PhD, DPhhc Vernon O. Underwood Family 2001–2018 Suraj P. Bhat, PhD Chair in Ophthalmology 2019–Present David S. Williams, PhD Established in 1995 as a term- appointment chair by Mrs. Adrienne 2019–Present Rory Smith, MD, and Family Endowed Chair Underwood Pingree in memory of Kolokotrones Chair in Ophthalmology her late husband, Mr. Vernon O. Established in 2019 by faculty alumna Established in 2004 by Wendy and Underwood. Dr. J. Bronwyn Bateman in honor Theo Kolokotrones to support the of her late husband, Dr. Roderick John R. Heckenlively, MD teaching and research of a cataract “Rory” Smith. 1997–2004 surgeon and scientist. Gary N. Holland, MD Smotrich Family Optometric Kevin M. Miller, MD 2004–2009 2005–Present Clinician-Scientist Chair Established in 2016 to support an Lynn K. Gordon, MD, PhD Laraine and David Gerber Chair in optometric clinician-scientist at the 2012–Present Ophthalmology UCLA Stein Eye Institute and will Walton Li Chair in Cornea and Uveitis Established in 1998 as a term- fund the appointee’s education and appointment chair by Mr. and Mrs. research programs. Established in 2013 by Walton W. Li, Gerber and, with an additional MD, as an administrative chair for the Ava K. Bittner, OD, PhD pledge, converted to a permanent- Cornea and Uveitis Division to further 2019–Present appointment chair in 2009. research and teaching activities. Joseph L. Demer, MD, PhD The Ahmanson Chair in Anthony J. Aldave, MD 2000–2004 Ophthalmology 2014–Present Established in 2006 by The Ahmanson Sherwin J. Isenberg, MD Foundation as an administrative chair 2004–2019 for the Retina Division Chief to further research, education, and clinical care programs. Steven D. Schwartz, MD 2007–Present

Philanthropy | UCLA STEIN EYE INSTITUTE 21 Doheny Eye Institute Endowed Stein Eye Institute Fellowship David May II Fellowship Fund Chairs Supporting Department Funds and Endowments Established in 1992 by the family of of Ophthalmology Faculty Mr. David May II to support advanced Abe Meyer Memorial Fellowship Fund study and research in ophthalmology A. Ray Irvine, Jr. MD, Chair in Established in 1969 by various and vision science. Clinical Ophthalmology donors to support clinical fellows at Christine Petersen, MD the Institute. John A. Irvine, MD 2018–2019 2014–Present Jonathan Young, MD, PhD Dr. Jack Rubin Memorial Fellowship 2018–2019 Charles Stewart Warren and Established in 1987 by the family of Hildegard Warren Endowed Adelaide Stein Miller Dr. Jack Rubin to support postdoctoral Research Chair Research Fellowship fellows. Established in 1977 by Mr. Charles Vikas Chopra, MD Miller as a tribute to his wife, Adelaide Elsa and Louis Kelton Fellowship 2017–present Stein Miller, Dr. Jules Stein’s sister. Endowed by the Keltons in 1982 to support postdoctoral research Flora L. Thornton Endowed Chair in Giovanni H. Greaves, MD and training. Vision Research 2018–2019 Nathan Abraham, MD Alfredo A. Sadun, MD, PhD Aramont Fellowship Fund 2018–2019 2014–Present Established in 2020 by the Aramont Frances Howard Goldwyn Fellowship Gavin S. Herbert Endowed Chair for Charitable Foundation to enable Macular Degeneration a domestic fellow in the Division Established in 1977 by Mr. Samuel of Orbital and Ophthalmic Plastic Goldwyn, Jr., with gifts from Mrs. Michael Ip, MD Surgery to pursue advanced training Goldwyn’s estate and Dr. and Mrs. 2019–Present under the mentorship of Dr. Robert Jules Stein. Alan Goldberg. Mary D. Allen Chair in Christopher Lo, MD 2018–2019 Vision Research Audrey and Jack Skirball Ocular Inflammatory Disease Fellowship Deming Sun, MD Frederic G. Rappaport Endowed 2015–Present Established in 2011 by The Skirball Fellowship in Retina/Oncology Foundation to support the training Established in 2004 by Mrs. Jeanne Rupert and Gertrude I. Steiger of fellows specializing in ocular A. Rappaport as a memorial to her Vision Research Chair inflammatory disease. son Frederic. Brian A. Francis, MD, MS Bert Levy Research Fellowship Fund Jerome Comet Klein, MD, 2015–Present Established in 1995 by Mr. Bert Fellowship and Lecture Fund Stephen J. Ryan-Arnold and Levy to enhance the educational Established in 2007 by the Irving & Mabel Beckman Foundation opportunities of vision-science Estelle Levy Foundation to provide Endowed Presidential Chair scholars and advance research in fellowship and lecture support in neuro-ophthalmology. the areas of orbital and ophthalmic SriniVas R. Sadda, MD plastic surgery. 2015–Present Cooperman Fellowship Fund Established in 1988 by the John and Theiline McCone Coopermans to support eye research Fellowship and education, with emphasis on Established in 1989 by the McCones clinical ophthalmology. to support and enhance education programs and fellowship training in David and Randi Fett Orbital macular disease. and Ophthalmic Plastic Surgery Fellowship Endowment Wei “Wayne” Gui, MD Established in 2013 by Dr. David R. 2018–2019 Fett and Ms. Randi Levine to support Niranjan Manoharan, MD fellows in the Orbital and Ophthalmic 2018–2019 Plastic Surgery Division. Justin Karlin, MD, MS 2018–2019

22 UCLA STEIN EYE INSTITUTE | Philanthropy Jules Stein Research Fellowship The Harold and Pauline Price Established in 1982 by various donors Fellowship to honor the memory of Charles Established in 1987 by the Louis Kenneth Feldman. and Harold Price Foundation to support research and education in Lindsay M. De Andrade, MD ophthalmology and vision care. 2018–2019 Terry Wood, MD Jennifer Pan, MD 2018–2019 2018–2019 Thelma and William Brand Klara Spinks Fleming Fellowship Fund Director’s Fund Established in 1985 by Klara Spinks Established in 2004 with a trust from Fleming to support cataract research. Mr. William F. Brand to benefit worthy Nathan Abraham, MD students at the Stein Eye Institute. 2018–2019 The Mae and Lee Sherman Leonard Apt Endowed Fellowship in Fellowship Fund Pediatric Ophthalmology Established in 1981 by the Sherman Established in 2002 by founding chief family to support postdoctoral fellows. of the Pediatric Ophthalmology and Amir Marvasti, MD Strabismus Division, Leonard Apt, MD, 2018–2019 to support outstanding clinical fellows in the field of pediatric ophthalmology Wilbur D. May Fellowship and strabismus. Established in 2013 by the May family Leonard Apt, MD, Pediatric as a tribute to Mr. Wilbur D. May, the Fellowship Fund beloved uncle of Mr. David May II. Established in 2015 by the trust of Jason Mingyi Huang, MD Leonard Apt, MD, founding chief of 2018–2019 the Pediatric Ophthalmology and Strabismus Division, to support pediatric ophthalmology fellowships. Lindsay M. De Andrade, MD 2018–2019 Jennifer Pan, MD 2018–2019

Rosalind W. Alcott Fellowship Established in 1978 by the Rosalind W. Alcott Charitable Remainder Trust for the training of outstanding postdoctoral fellows. Nikisha A. Kothari, MD 2018–2019

Sanford and Erna Schulhofer Fellowship Fund Established in 1986 by Mr. Sanford Schulhofer to support postdoctoral research and training in vision science.

Philanthropy | UCLA STEIN EYE INSTITUTE 23 Endowments for Research, JSEI Maintenance Fund Education, and Patient Care Katherine L. Gardner Research Fund Louis and Annette Kaufman Fund Albert Sarnoff Endowed Cataract Fund Maggi Kelly Vision Fund Amalia Simon Roth Endowment Marie and Jerry Hornstein Family Anne H. West Estate Fund Endowed Macular Degeneration Anthony Eannelli Endowment for Research Fund Retina Research Michael Huffington Ophthalmology Arna Saphier Macular Degeneration Scholarship Fund Fund Pat and Joe Yzurdiaga Arthur Spitzer Fund Endowed Cataract Fund Audrey Hayden-Gradle Trust Patricia and Joseph Yzurdiaga Barbara P. Taylor Fund Endowed Vision Science Research Fund Bradley R. Straatsma Research Fund Patricia Pearl Morrison Research Fund Card Family Research Fund Paul J. Vicari Endowed Cataract Chesley Jack Mills Trust Research Fund Daniel B. Whipple Fund Raymond and Ruth Stotter Dr. William F. Stein and Esther Vision Science Research Fund Elizabeth Stein Memorial Fund Richard B. Shapiro Vision Fund Edward and Hannah Carter Fund Sara Kolb Memorial Fund Elsie B. Ballantyne Regents Fund Stella F. Joseph Fund Elsie B. Ballantyne UCLA Foundation The Annenberg Foundation Fund Fund The Karl Kirchgessner Foundation Emily G. Plumb Estate and Trust Ophthalmology Endowment Fund Emma B. Gillespie Fund The Leonard Apt, MD, Pediatric Endowment for Children with Uveitis EyeSTAR Residency Training Fund Esther Shandler Research Fund The Leonard Apt, MD, Pediatric Ophthalmology Fund Gerald Oppenheimer Family Foundation Center for the Prevention The Skirball Foundation Fund of Eye Disease Endowment Fund UCLA Center for Eye Epidemiology Harold B. and Bernice L. Belfer Fund Uncle Claude Fund Henry I. Baylis, MD, Endowed Fund in Virginia Burns Oppenheimer Orbital and Ophthalmic Plastic Surgery Endowment Fund Herb Ritts, Jr., Memorial Vision Fund Wickham Retina Research Fund Herman King Fund William R. Payden Fund for Hintze Glaucoma Research Fund Glaucoma Research J. Richard Armstrong and William, Richard, & Roger Meyer Fund Ardis Armstrong Fund Jerome T. Pearlman, MD, Fund John and Theiline McCone Macular Disease Research Fund

24 UCLA STEIN EYE INSTITUTE | Philanthropy Eye Health Programs Patient Care Services UCLA Stein Eye Institute The Stein Eye Institute is a vision- Committed to advancing eye health, UCLA Department of Ophthalmology board- science campus in Westwood that is certified faculty provide services ranging from routine eye examinations to the most home to state-of-the-art clinics, labora- complex sight-saving procedures. tories, and an outpatient surgical center The UCLA Stein Eye Institute and its affiliation partner, the Doheny Eye Institute, equipped with the most advanced tools are ranked among the top in the nation for ophthalmology. Patients and referring for precision surgery. physicians alike trust UCLA Department of Ophthalmology faculty to provide the Direct consultation and treatment, highest level of care across every subspecialty, with premier services available at including emerging therapies, is avail- the UCLA Stein Eye Institute vision-science campus in Westwood, as well as at the able through the Ophthalmology UCLA Stein Eye Centers and Doheny Eye Centers UCLA neighborhood locations Faculty Consultation Service. Our across the Southland. faculty members have extensive, advanced training in ophthalmic subspecialties and afford referring physicians and patients with a valuable COUNTY Olive View-UCLA Medical Center SYLMAR resource for special eye problems. Additionally, wide-ranging and subspe-

Veterans Affairs cialty eye care in all medical and surgi- LOS ANGELES Healthcare System cal areas of ophthalmology is offered Stein Eye Center UCLA SEPULVEDA Doheny Eye Center UCLA CALABASAS through the Comprehensive Ophthal- VENTURA COUNTY PASADENA mology Division, which is staffed by members of the UCLA Medical Group. UCLA Stein Eye Institute WESTWOOD The Institute’s outpatient surgical Doheny Eye Center UCLA ARCADIA center, housed in the award-winning Edie & Lew Wasserman Building, sets the standard for excellence in patient Veterans Affairs Healthcare System care and medical progress. Ophthalmic Stein Eye Center UCLA WEST LOS ANGELES SANTA MONICA surgery of every kind—from cataract extraction and laser vision-correction LOS ANGELES COUNTY surgeries to removal of ocular tumors— ORANGE COUNTY is performed. Faculty members and skilled medical specialists, including Harbor-UCLA Medical Center TORRANCE subspecialty fellows, medical residents, anesthesiologists, nurses, and technicians, ensure that each patient receives the highest quality preoperative and postoperative care possible. Doheny Eye Center UCLA The Ophthalmology Inpatient Con- ORANGE COUNTY sultation Service, operating 24 hours a day through the Ronald Reagan UCLA Medical Center and UCLA Medical Center Santa Monica, provides ophthalmic consultation and treatment to UCLA Department of Ophthalmology pediatric and adult patients who are Los Angeles and Beyond admitted to the medical centers for inpatient care. The consultation team consists of physician-residents at the UCLA Stein Eye Institute, with subspecialty coverage provided by UCLA Department of Ophthalmology faculty.

100 Stein Plaza, UCLA Los Angeles, CA 90095 Learn more about our Referral Service: (310) 825-5000 LOCATIONS, PROVIDERS, and Emergency Service: (310) 825-3090 SERVICES at: After-Hours Emergency Service: www.uclahealth.org/eye/ (310) 825-2111 our-locations.

26 UCLA STEIN EYE INSTITUTE | Eye Health Programs UCLA Stein Eye Centers Doheny Eye Centers UCLA The UCLA Stein Eye Centers in Cala- Stein Eye Center–Santa Monica Convenient Doheny Eye Center UCLA basas and Santa Monica provide excel- The Stein Eye Center–Santa Monica locations across the Southland set the lence in clinical care along with neigh- offers the world-renowned compre- standard for excellence, with UCLA borhood convenience. At each Center, hensive and subspecialty eye care Department of Ophthalmology faculty UCLA Department of Ophthalmology of the UCLA Stein Eye Institute at a providing the finest clinical care, sur- faculty provide a full array of subspe- convenient neighborhood location. gical services, diagnostic testing, and cialty care, surgical services, and diag- The Center features well-equipped treatment available. nostic testing. examination rooms, an optical shop, Doheny Eye Center UCLA–Arcadia on-site parking for easy access, and Stein Eye Center–Calabasas testing facilities offering a wide range The Doheny Eye Center UCLA–Arcadia The Stein Eye Center–Calabasas proof examinations, including visual field, serves patients in the broader Arcadia vides comprehensive and subspecialty corneal mapping (corneal topography), region and San Gabriel area, expand- eye care. Conveniently located directly intraocular lens measurement, fluores- ing the UCLA Department of Ophthal- off the 101 freeway, the newly built Cen- cein angiography, spectral domain opti- mology’s reach in Los Angeles County. ter features fully equipped examina- cal coherence tomography, and other The renovated office includes 12 exam tion rooms, free on-site parking, and diagnostic retinal imaging techniques. rooms, dedicated diagnostic equip- subspecialty care including cataract Expert ophthalmologists at the Stein ment, and attractive patient areas. The and LASIK surgery; glaucoma; diabetic Eye Center–Santa Monica offer nearly Center provides comprehensive oph- retinopathy; macular degeneration; and all the subspecialty services, diag- thalmology, and nearly all subspecialty functional and cosmetic oculoplastics. nostic testing, and treatment services services, including cornea, glaucoma, A wide range of ocular assessment is available at the Stein Eye Institute in and retina. available, including visual field testing; Westwood. The Doheny Eye Center–Arcadia corneal mapping (corneal topography); is easily accessible from two freeways intraocular lens measurement; fluores- 1807 Wilshire Blvd., Suite 203 and provides free, on-site parking. cein angiography; spectral domain opti- Santa Monica, CA 90403 cal coherence tomography; and other Telephone: (310) 829-0160 622 W. Duarte Rd., Suite 101 diagnostic retinal imaging techniques. Fax: (310) 829-0170 Arcadia, CA 91007 The Stein Eye Center–Calabasas Telephone: (626) 254-9010 offers nearly all the subspecialty ser- Fax: (626) 254-9019 vices, diagnostic testing, and treat- Doheny Eye Center UCLA– ment services available at the UCLA Orange County Stein Eye Institute in Westwood, with the UCLA faculty you know and trust. The Doheny Eye Center UCLA–Orange County is located in the Orange Coast 26585 W. Agoura Rd., Suite 330 Memorial Medical Center and broadens Calabasas, CA 91302 the reach of the UCLA Department Telephone: (310) 825-5000 of Ophthalmology south to Orange Fax: (310) 825-9246 County. The location offers comprehensive ophthalmology, as well as cornea, glaucoma, neuro-ophthalmology, pediatric and uveitis subspecialty services, and retina. The Doheny Eye Center UCLA– Orange County includes 12 exam rooms, dedicated diagnostic equipment, and comfortable patient areas.

Orange Coast Memorial Medical Center 18111 Brookhurst St., Suite 6400 Fountain Valley, CA 92708 Telephone: (714) 963-1444 Fax: (714) 963-1234

Eye Health Programs | UCLA STEIN EYE INSTITUTE 27 Doheny Eye Center UCLA–Pasadena The Doheny Eye Center UCLA– Pasadena serves as the primary hub of the Doheny Eye Centers UCLA. Located on the second floor of theHuntington Pavilion, the Center provides expanded vision care services and clinics devoted to retina and cornea; comprehensive ophthalmology and oculoplastics; neuro-ophthalmology; and glaucoma. Each subspecialty clinic has dedicated, UCLA Department of Ophthalmology state-of-the-art diagnostic laser suites, as well as in-office procedure rooms. 1 Summary of Patient Care Statistics Complex procedures are performed at the Huntington Pavilion Surgical Suites, which are located on the building’s 2018–2019 2019–2020 third floor. The Doheny Eye Center UCLA– Pasadena, located in the Huntington FACULTY CONSULTATION SERVICE Pavilion, is home to a wide variety of Patient visits 153,771 140,963 medical practitioners, which provides physicians with ease of referral for patients requiring specialized eye care and provides patients with the added convenience of seeing their doctors INPATIENT CONSULTATION SERVICE and having any necessary services all Patient evaluations 781 581 in one location. Huntington Pavilion 625 S. Fair Oaks Blvd., 2nd Floor Pasadena, CA 91105 CLINICAL LABORATORIES Telephone: (626) 817-4747 Procedures 92,235 84,837 Fax: (626) 817-4748

SURGERY SERVICES Number of procedures1 22,596 16,417 Intravitreal Injections 12,748 12,633

MOBILE EYE CLINIC Number of patients 9,675 7,930 Ocular abnormalities 33% 29% Number of trips 410 308

1Includes lasers

Note: Due to COVID-19, our outpatient visits and surgical procedures in the 2019–2020 academic year were down1.

28 UCLA STEIN EYE INSTITUTE | Eye Health Programs Centers and Laboratories

Research and Treatment Diagnostic Services Research Laboratories Centers Ophthalmology diagnostic services Laboratory-based research, also called The Research and Treatment Centers provide testing that offers precise mea- basic vision-science research, forms provide subspecialty care from faculty surements, photographs, and quantita- the foundation for the clinical research, physicians who are actively involved in tive studies of the eye and the visual education, and patient care that are related research, enabling emerging system. Diagnostic testing increases the visible hallmarks of the UCLA Stein and experimental treatment options to the accuracy of diagnosis and further Eye Institute. The Institute has over be developed for a gamut of eye dis- augments the effectiveness of disease 20 specially equipped laboratories to orders. In addition to comprehensive management. Our diagnostic services support vision-science investigations. treatment, the centers provide both are available to eye care physicians in Organized around the interests of the patients and physicians with expert the community. research faculty, these distinct labo- diagnostic and consultation services ff Anterior Segment Diagnostic ratories offer unique opportunities for for diseases that are difficult to iden- Laboratory students, physicians, and fellows to tify and treat. Ophthalmology faculty ff Corneal Diagnostics become involved in internationally and work closely with other specialists, nationally renowned scientific study. ff Glaucoma Imaging Laboratory both within the Stein Eye Institute and ff Advanced Robotic Eye Surgery in other UCLA clinical departments, to ff Medical Photography/Ultrasound f ff Ocular Motility Clinical and f Biology and Genetics of create a multidisciplinary team custom- Retinal Disease ized for each patient’s unique medi- Basic Science Laboratory ff Cornea Biology Laboratory cal needs. ff Visual Field Laboratory f ff Cornea Genetics ff Aesthetic Center f Visual Physiology Diagnostic Laboratory ff Developmental Neurobiology ff Center for Community Outreach Laboratory and Policy ff Glaucoma Advanced Imaging UCLA Center for Eye Laboratory Epidemiology ff Lens Biophysics Laboratory UCLA Mobile Eye Clinic ff Molecular Biology of Retinal ff Center to Prevent Childhood Ganglion Cells Laboratory Blindness ff Molecular Neurobiology ff Center for Regenerative Medicine Laboratory in Ophthalmology ff Ophthalmic Biophysical Chemistry ff Clinical Research Center ff Ophthalmic Pathology Laboratory ff Contact Lens Center ff Photoreceptor Biochemistry ff Diabetic Eye Disease and Laboratory Retinal Vascular Center ff Photoreceptor/RPE Cell Biology ff Eye Trauma and Emergency f Center f Retina Biochemistry and Clinical Disease Modeling Laboratory ff Gerald Oppenheimer Family f Foundation Center for the f Retinal Biochemistry Laboratory Prevention of Eye Disease ff Retinal Cell Biology Laboratory ff Glaucoma Center for Excellence ff Retinal Neurophysiology in Care and Research Laboratory ff Macular Disease Center ff Vision Molecular Biology ff Ocular Inflammatory Disease Laboratory Center ff Visual Physiology Laboratory ff Ophthalmic Oncology Center ff Optic Neuropathy Center ff Orbital Disease Center Find out more about our ff UCLA Laser Refractive Center RESEARCH LABORATORIES at: ff Vision Genetics Center www.uclahealth.org/eye/ ff Vision Proteomics Center research-laboratories. ff Vision Rehabilitation Center

Eye Health Programs | UCLA STEIN EYE INSTITUTE 29 Training Programs

The UCLA Department of Ophthalmol- ogy provides comprehensive training in ophthalmology and vision science to medical students, residents, and clinical and research fellows. Training programs encompass the gamut of ophthalmic and vision-science education, incorporating a full range of subjects in the study of the eye. Serving a large patient population with diverse vision problems offers innumerable training opportunities for both residents and clinical fellows, while the availability of a multitude of research laboratories ensures a wide choice of vision-science projects for all trainees. Predoctoral and postdoctoral research fellows benefit from the wealth of new and unfolding research generated by UCLA Department of Ophthalmology vision scientists.

Medical Students Through the UCLA Medical Student Program, each academic year the UCLA Department of Ophthalmology extends instruction to UCLA medical students in their second, third, and fourth years of instruction. Through lectures, small group discussions, and clinical experience, all students have numerous training sessions from which to gain knowledge about eye diseases and develop eye examination skills that should be known by all physicians, regardless of their specialties. Students who are interested in ophthalmology as a career have additional learning opportunities in elective courses.

Medical Student Research Ophthalmology Program The UCLA Medical Student Research Program provides select medical students with a year-long opportunity to participate in laboratory or clinical research in the field of ophthalmology. The goal of the program is to encourage medical students to pursue careers in academic ophthalmology.

30 UCLA STEIN EYE INSTITUTE | Eye Health Programs Residents The UCLA Department of Ophthalmol- EyeSTAR: Combining Basic Science ogy Residency Program is ranked one Research with Clinical Practice of the top in the country and covers the For physicians interested in academic full breadth of ophthalmology training careers and professional leadership as from general ophthalmology to oph- clinician-scientists, the Stein Eye Insti- thalmic subspecialties. The accredited tute offers the Ophthalmology Specialty three-year residency program trains Training and Advanced Research Pro- 24 residents with eight new residents gram, referred to as EyeSTAR, which beginning the program each July. offers vision-science training com- Training incorporates the resources bined with an ophthalmology residency. of the UCLA Stein Eye Institute, Harbor- Appointees complete a residency pro- UCLA Medical Center, Olive View- gram leading to certification in ophthal- UCLA Medical Center, and the Veterans mology, as well as laboratory research Affairs Greater Los Angeles Health- experience leading to a doctorate, care System at West Los Angeles and or postdoctoral training in the event Sepulveda. Through their clinical rota- that the trainee already has a doctor- tions, every resident has exposure to ate. EyeSTAR trainees work under the each medical center and gains clinical guidance of a faculty advisory panel experience with a broad range of oph- representing the clinical and research thalmic problems and patient popu- interests of each trainee. lations. Certification by the American EyeSTAR is recognized by the Board of Ophthalmology is a natural National Eye Institute and the Associ- objective of the program. ation of University Professors of Oph- thalmology as a model training program EyeMBA: Innovation in for clinician-scientists in ophthalmology. Medical Education Recognizing that future leaders in ophthalmology will need the financial, management, and measurement skills that are at the core of an MBA curriculum, the Stein Eye Institute created a national first for medical education with EyeMBA—a master’s of business administration degree that is earned in tandem with an ophthalmology residency. The only joint program of its kind, the Stein Eye Institute developed EyeMBA with the David Geffen School of Medi- cine at UCLA and the UCLA Anderson School of Management. Residents in the EyeMBA program gain skills that are broadly applicable to ophthalmologic leadership in academia, translational research, health system management, health care delivery, and the biomedical industry.

Eye Health Programs | UCLA STEIN EYE INSTITUTE 31 Fellows The UCLA Department of Ophthalmol- Clinical Fellowship Training International Fellowship Training ogy offers particularly well-qualified Following successful completion of the To promote and encourage research persons the opportunity to receive residency program, clinical fellowship and education interaction with oph- fellowship training in vision-science training combines outpatient, inpatient, thalmology institutions throughout the research or specific areas of clinical and surgical experience in an ophthal- world, the Stein Eye Institute offers an ophthalmology. mic subspecialty. The fellow assumes International Ophthalmology Fellow- increasing responsibility for patient ship and Exchange Program consisting Vision Science Fellowship Training care under the supervision of faculty of one-year to two-year fellowships Vision science fellowship training is members responsible for the program. under the supervision of specific Insti- laboratory based and offers both pre In addition to receiving training from tute faculty. Candidates for these fel- doctoral and postdoctoral opportu- faculty, the fellow instructs medical lowships are nominated by prestigious nities to trainees in specific areas of students and residents. Research is institutions outside the United States vision science that encompass a wide considered an important aspect of spe- and often hold academic positions range of topics. Trainees work under cialty training and a major prerequisite within their own countries. Fellows the supervision of UCLA Department for assimilating future developments in participate in the clinical and research of Ophthalmology faculty members ophthalmology. Fellows are expected activities of ophthalmic subspecialties who are engaged in basic-science to undertake independent investigation according to their training needs. research and have active laborato- or to participate in one of the ongoing ries. The predoctoral or postdoctoral research projects in a field related to trainee and his/her faculty mentor their specialty. develop the scope and nature of the The UCLA Department of Ophthal- Find detailed information about our TRAINING PROGRAMS at: training program. mology offers clinical fellowships in the https://www.uclahealth.org/ An integrated program is also offered following subspecialty areas: under the auspices of a National Eye eye/training-programs. ff Cornea and External Ocular Institute Vision Science Training Grant Diseases and Refractive Surgery for predoctoral and postdoctoral fel- ff Glaucoma lows. The grant provides trainees with f coordinated and organized exposure f Medical Retina to a wide range of techniques, giv- ff Neuro-Ophthalmology ing each fellow the broadest possible ff Ophthalmic Pathology background in ophthalmology and the ff Orbital and Ophthalmic basic sciences. Plastic Surgery ff Pediatric Ophthalmology and Strabismus ff Uveitis and Inflammatory Eye Disease ff Vitreoretinal Diseases and Surgery

32 UCLA STEIN EYE INSTITUTE | Eye Health Programs Faculty and Colleagues UCLA Department of Ophthalmology Academic Divisions at Stein Eye Institute (SEI) and Doheny Eye Centers UCLA (DEC)

CATARACT AND GLAUCOMA RETINA REFRACTIVE SURGERY Joseph Caprioli, MD, Chief SEI Gad Heilweil, MD John D. Bartlett, MD Vikas Chopra, MD Hamid Hosseini, MD Shawn Lin, MD Anne L. Coleman, MD, PhD Jean-Pierre Hubschman, MD Kenneth L. Lu, MD Brian A. Francis, MD, Chief DEC Michael S. Ip, MD, Chief DEC Kevin M. Miller, MD, Chief SEI JoAnn A. Giaconi, MD Allan E. Kreiger, MD Mitra Nejad, MD Alex A. Huang, MD, PhD Tara A. McCannel, MD, PhD Optometrists Simon K. Law, MD, PharmD Pradeep S. Prasad, MD, MBA Tony Chan, OD Kouros Nouri-Mahdavi, MD Steven D. Schwartz, MD, Chief SEI Carolyn Duong, OD Natik Piri, PhD Irena Tsui, MD Amanda P. Havens, OD James C. Tan, MD, PhD Optometrists Linda Hwang, OD Melissa W. Chun, OD NEURO-OPHTHALMOLOGY Mark Landig, OD Jennie Kageyama, OD Anthony C. Arnold, MD, Chief SEI COMPREHENSIVE OPHTHALMOLOGY Laura Bonelli, MD RETINAL DISEASES AND Gavin G. Bahadur, MD Lynn K. Gordon, MD, PhD OPHTHALMIC GENETICS Rachel Feit-Leichman, MD Stacy L. Pineles, MD Michael B. Gorin, MD, PhD, Chief SEI Tania Onclinx, MD Peter A. Quiros, MD Phillip Le, MD, PhD Susan S. Ransome, MD Alfredo A. Sadun, MD, PhD, Chief DEC Colin A. McCannel, MD Meryl L. Shapiro-Tuchin, MD Steven Nusinowitz, PhD OPHTHALMIC PATHOLOGY Ronald J. Smith, MD SriniVas R. Sadda, MD Victoria Yom, MD Ben J. Glasgow, MD David Sarraf, MD Optometrists ORBITAL AND OPHTHALMIC VISION SCIENCE Michael Baker, OD PLASTIC SURGERY Steven A. Barnes, PhD Benjamin Graham, OD Cynthia A. Boxrud, MD Suraj P. Bhat, PhD Vivian Shibayama, OD Robert Alan Goldberg, MD, Chief SEI Nicholas C. Brecha, PhD Daniel B. Rootman, MD Gordon L. Fain, PhD CORNEA AND UVEITIS Soheab Ugradar, MD Debora B. Farber, PhD, DPhhc Anthony J.Aldave, MD, Chief SEI Ben J. Glasgow, MD Saba Al-Hashimi, MD PEDIATRIC OPHTHALMOLOGY Joseph Horwitz, PhD Benjamin B. Bert, MD AND STRABISMUS Wayne L. Hubbell, PhD Sophie X. Deng, MD, PhD Joseph L. Demer, MD, PhD, Chief SEI Steven Nusinowitz, PhD Simon Fung, MD Simon Fung, MD Yirong Peng, PhD Gary N. Holland, MD Monica R. Khitri, MD Natik Piri, PhD Hugo Y. Hsu, MD, Chief DEC Stacy L. Pineles, MD Roxana A. Radu, MD John A. Irvine, MD Soh Youn Suh, MD Alapakkam P. Sampath, PhD, Chief SEI Batool Jafri, MD Federico G. Velez, MD Deming Sun, MD Olivia L. Lee, MD Optometrist Hui Sun, PhD Bartly J. Mondino, MD, Department Chair Laura Robbins, OD Gabriel H. Travis, MD Edmund Tsui, MD David S. Williams, PhD Xian-Jie Yang, PhD Yuhua Zhang, PhD Jie Zheng, PhD Find out more about our ACADEMIC DIVISIONS and FACULTY at: www.uclahealth.org/eye/ academic-divisions.

34 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Bartly J. Mondino, MD

Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Distinguished Professor of Ophthalmology Chair, UCLA Department of Ophthalmology Director, Stein Eye Institute Affiliation Chair, Doheny Eye Institute Board of Directors, Stein Eye Institute Board of Directors (Observer), Doheny Eye Institute Board of Directors, National Alliance for Eye and Vision Research/ Alliance for Eye and Vision Research Member, UCLA Brain Research Institute Member, Medical Advisory Board, Braille Institute

Dr. Mondino was named director of the Stein Eye Institute and chair of the UCLA Department of Ophthalmology in 1994, the culmination of a career in research and clinical care in cornea and infectious eye diseases. As director and chair, Dr. Mondino has expanded the Stein Eye Institute’s pillar programs; increased faculty support through the creation of endowed chairs; forged a historic affiliation with the Doheny Eye Institute; and broadened access to eye care with the opening of Stein and Doheny Eye Center UCLA locations across the Southland. Through development and completion of the Edie & Lew Wasserman Building in 2014, redesign of Stein Plaza in 2015, and renovation of the Jules Stein Building in 2017, Dr. Mondino transformed the Stein Eye Institute into a vision-science campus at UCLA, creating a focal point for patient care, vision research, education, and community outreach at home and abroad.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 35 FACULTY, UCLA STEIN EYE INSTITUTE

Anthony J. Aldave, MD Saba Al-Hashimi, MD Anthony C. Arnold, MD

Walton Li Chair in Cornea and Uveitis Health Sciences Assistant Clinical Mary Oakley Foundation Chair in Professor of Ophthalmology Neurodegenerative Diseases Professor of Ophthalmology Professor of Clinical Ophthalmology Chief of the Cornea and Uveitis Division Cornea, External Disease, and Chief of the Neuro-Ophthalmology Refractive Surgery Specialist Division Discovering the Genetic Basis Dr. Al-Hashimi is a clinician with a Director of the UCLA Optic Neuropathy of the Corneal Dystrophies Center research interest in keratoconus and Dr. Aldave’s clinical specialties are cor- corneal crosslinking. His research focus Vice Chair, Education nea and external disease. His labora- involves halting the progression of cor- tory research focuses on the molecular neal disease by using light and chemi- Ischemic and Inflammatory Diseases genetics of the corneal dystrophies, cals to strengthen the cornea. of the Optic Nerve a group of inherited disorders that Specializing in infections of the cor- Dr. Arnold’s clinical expertise is in affect corneal clarity and constitute one nea, Dr. Al-Hashimi performs surgi- neuro-ophthalmology, with a special of the primary indications for corneal cal procedures that include corneal emphasis on ischemic and inflamma- transplantation. transplantation, Descemet membrane tory optic neuropathies and manifes- Dr. Aldave provides clinical care at stripping endothelial keratoplasty, tations of tumors, stroke, and inflam- the Stein Eye Institute in Westwood. Descemet membrane endothelial kera mation of the central nervous system. toplasty, deep anterior lamellar kerato- His research has focused on advanced plasty, corneal patch grafts, pterygium imaging techniques to identify optic surgery, corneal repair, cataract sur- nerve circulatory diseases and to inves- gery, and premium cataract surgery tigate their causes. with femtosecond laser. Dr. Arnold provides clinical care at Patients can see “Dr. Saba” at the the Stein Eye Institute in Westwood. UCLA Stein Eye Institute.

36 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Gavin G. Bahadur, MD John D. Bartlett, MD Suraj P. Bhat, PhD

Health Sciences Assistant Clinical Health Sciences Associate Clinical Oppenheimer Brothers Chair Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Member of the Molecular Biology Institute Cataract Surgery Outcomes and Cataract and Refractive Surgery, Glaucoma Detection Clinical Informatics Molecular Biology of Vision Dr. Bahadur’s clinical specialties are Dr. Bartlett’s clinical interest is cataract comprehensive ophthalmology includ- and refractive cataract surgery, with the Dr. Suraj Bhat’s research impacts two ing cataract, pterygium, and glaucoma. goal to improve the focus of the eyes, important areas of vision: the ocular His research activities include machine- reduce dependence on glasses, and lens in the anterior eye and the retinal learning algorithms for cataract surgery restore vision potential. He teaches pigment epithelium (RPE) in the pos- outcomes and glaucoma detection. Stein Eye residents, training the next terior eye. His laboratory, the Vision Dr. Bahadur provides clinical care generation of eye surgeons to deal Molecular Biology Laboratory (VMBL) at the Stein Eye Center–Santa Monica. with challenging cases. investigates gene activity that sustains He also performs manual small incision Dr. Bartlett is a UCLA physician infor transparency within the ocular lens and cataract surgery (MSICS) with Surgical maticist and is involved in the imple- gene activity that sustains the physio- Eye Expeditions International. mentation and optimization of elec- logical health of the RPE, which in turn tronic health records (EHRs) to promote sustains the neural activity in the ret- effective organization, analysis, man- ina that makes vision possible. VMBL agement, and use of clinical informa- is involved in delineating very early tion. He is interested in using EHRs to events (at the genomic and molecular enhance patient care, improve pop- level) that culminate in cataractogene- ulation health, and decrease health sis in the ocular lens and age-related care costs. macular degeneration in the RPE. Dr. Bartlett provides clinical care at the Stein Eye Institute in Westwood.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 37 FACULTY, UCLA STEIN EYE INSTITUTE

Ava K. Bittner, OD, PhD Laura Bonelli, MD Nicholas C. Brecha, PhD

Smotrich Family Optometric Health Sciences Assistant Clinical Distinguished Professor of Neurobiology, Clinician-Scientist Chair Professor of Ophthalmology Ophthalmology, and Medicine Chief of Optometric Services Member of the Brain Research Institute Associate Professor of Ophthalmology Neuro-Ophthalmology Member of CURE: Center for Digestive Diseases Dr. Bonelli completed her residency in Low Vision Rehabilitation ophthalmology, as well as fellowships Member of the California NanoSystems Institute in neuro-ophthalmology and oculoplas- Dr. Bittner’s specialty is low vision tics, at the Hospital de Clínicas, Univer- rehabilitation. Her research activities sity of Buenos Aires, Argentina. Functional and Structural include clinical trials to assess the use Joining the UCLA Department of Organization of the of novel approaches and technolo- Mammalian Retina Ophthalmology in 2008, Dr. Bonelli gies to improve access to low vision specializes in comprehensive ophthal- rehabilitation care and reading ability Dr. Brecha is a visual system neurosci- mology and neuro-ophthalmology. She with visual assistive aids. Specifically, entist whose expertise includes retinal sees patients at the Stein Eye Institute she is evaluating tele-rehabilitation, neurochemistry, transmitters, synaptic in Westwood and the Stein Eye Center– Bluetooth low energy beacon sensors, and cellular structure, and neuronal cir- Santa Monica. socially assistive robots, and wearable cuitry regulating visual function. A committed educator, Dr. Bonelli electronic visual enhancement devices His current research studies are fur- teaches medical student courses at for low vision. thering the understanding of 1) funda the David Geffen School of Medicine, Dr. Bittner provides clinical care at mental synaptic inhibitory processes regularly lectures at educational con- the Stein Eye Institute’s Vision Reha- mediating early vision in the outer ret- ferences, and instructs residents and bilitation Center located in the Doris ina and 2) neuronal cell structure and neuro-ophthalmology fellows in the Stein Building. function mediating visual processing Department. She is the director of in the inner retina. inpatient consultation services for the His studies are a prerequisite for Ronald Reagan UCLA Medical Cen- understanding normal retinal function, ter and UCLA Medical Center, Santa and the impact on the development of Monica, where she oversaw a broad therapeutic approaches and diagnostic reorganization to improve services tools essential for the treatment, pre- and to provide more efficient patient vention, and restoration of vision loss care. In recognition of her work with due to retinal injury and disease. ophthalmology residents on the consultation services, Dr. Bonelli received the Stein Eye Institute Faculty Teaching Award in 2014.

38 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Joseph Caprioli, MD Anne L. Coleman, MD, PhD Joseph L. Demer, MD, PhD

David May II Chair in Ophthalmology The Fran and Ray Stark Foundation Arthur L. Rosenbaum, MD, Chair in Chair in Ophthalmology Pediatric Ophthalmology Distinguished Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Chief of the Glaucoma Division Professor of Epidemiology, Jonathan and Professor of Neurology Karin Fielding School of Public Health Director, Clinical and Research Chief, Pediatric Ophthalmology and Glaucoma Fellowship Director of the Stein Eye Institute Strabismus Division Centers for Community Outreach and Chair, Ophthalmology Quality Director, Fellowship in Pediatric Policy, Eye Epidemiology, and the Improvement Committee Ophthalmology and Strabismus UCLA Mobile Eye Clinic Director, Ocular Motility Laboratories Vice Chair of Academic Affairs, Causes and New Treatments UCLA Department of Ophthalmology Chair, EyeSTAR Residency PhD/PostDoc for Glaucoma Program in Ophthalmology and Visual Science Dr. Caprioli’s clinical specialties are Glaucoma, Cataract, and glaucoma, cataract, and anterior seg- Public Health Motility and Vision ment surgery. His long-term objectives Dr. Coleman’s clinical specialties are in clinical and basic research are to iden- glaucoma and cataract. Her research Dr. Demer’s clinical specialties include tify those individuals at greatest risk for activities include the etiology, diagnosis, pediatric ophthalmology, adult stra- visual loss and to implement new treat- treatment, and societal impact of glau- bismus, and other disorders of ocular ment through effective neuroprotective coma, cataracts, and pediatric eye dis- motility such as nystagmus. He is a strategies. Laboratory work focuses eases including quality-of-life research biomedical engineer whose federally on mechanisms of retinal ganglion for patients impacted by these eye dis- funded research includes anatomy and cell damage in glaucoma, with special eases. Her research encompasses the imaging of the eye muscles, and the emphasis on early detection through interface of eye care and public health biomechanics of eye movements and accurate assessment of the optic nerve focusing on underserved areas. optic nerve disorders. and nerve fiber layer to measure the Dr. Coleman provides clinical care Dr. Demer provides clinical care and rate of progressive damage. at the Stein Eye Institute in Westwood. ophthalmic surgery at the Stein Eye Dr. Caprioli provides clinical care at Institute in Westwood. the Stein Eye Institute in Westwood.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 39 FACULTY, UCLA STEIN EYE INSTITUTE

Sophie X. Deng, MD, PhD Debora B. Farber, PhD, Simon Fung, MD DPhhc Joan and Jerome Snyder Chair in Assistant Professor of Ophthalmology Cornea Diseases Distinguished Professor Professor of Ophthalmology of Ophthalmology Pediatric Cornea and Member of the UCLA Jonsson Doctor honoris causa Anterior Segment Specialist Comprehensive Cancer Center Member of the Brain Research Institute Dr. Fung specializes in cornea and Member of the UCLA Broad Stem Cell Member of the Molecular Biology Research Center anterior segment diseases, with a par- Institute ticular focus on those occurring among children and adolescents. His areas Limbal Stem Cell Deficiency Retinal Biochemistry, Molecular of surgical expertise include pediatric Dr. Deng specializes in corneal and Biology, Genetics of Retinal corneal transplantations using modern external ocular diseases, and cataracts. Degenerations, and Studies on strategies, such as endothelial kerato- Her surgical areas include endothelial Embryonic Stem Cell-Derived plasty (DSAEK and DMEK) and deep Extracellular Vesicles keratoplasty (DSEK and DMEK), deep anterior lamellar keratoplasty (DALK) anterior lamellar keratoplasty (DALK), Dr. Farber’s research focuses on the techniques, as well as pediatric anterior penetrating keratoplasty, limbal stem characterization of genes encoding key eye conditions such as cataracts and cell transplantation, artificial cornea, proteins in vision that when mutated glaucoma. His research focuses on the and cataract. cause blinding diseases. Examples: evaluation and treatment of complex Dr. Deng is the director of the Cor- β-PDE gene (diseases in mice, dogs, ocular surface conditions, notably neu- nea Biology Laboratory at Stein Eye. and human RP), RP1 gene (dominant rotrophic keratopathy and phlyctenular Her research focuses on corneal epi- RP), rd7 gene (Enhanced S-Cone syn- keratoconjunctivitis. thelial stem cell regulation, deficiency, drome), and ZBED4 and RHBDD2 Dr. Fung provides clinical care at the and regeneration. She aims to improve genes (arCRD and arRP, respectively). UCLA Stein Eye Institute in Westwood, the current treatment for patients with In addition, Dr. Farber studies ocular and has staffed the UCLA Mobile Eye limbal stem cell deficiency by using albinism resulting from mutations in Clinic since 2018. stem cell therapy to restore vision. the OA1 gene, and the components of Dr. Deng also conducts clinical studies the OA1 cascade controlling RPE mela to develop new imaging and molecular nosomes’ biogenesis as well as guid- tests to accurately diagnose and stage ance of ganglion cell axons through the limbal stem cell deficiency. brain’s optic chiasm. Lastly, Dr. Farber investigates the use of microvesicles released from embryonic stem cells for the rescue of damaged retinas.

40 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues JoAnn A. Giaconi, MD Ben J. Glasgow, MD Robert Alan Goldberg, MD

Health Sciences Clinical Professor The Wasserman Professor Bert O. Levy Endowed Chair in of Ophthalmology of Ophthalmology Orbital and Ophthalmic Plastic Surgery Chief of the Ophthalmology Section Professor of Pathology and Professor of Ophthalmology at the Greater Los Angeles Laboratory Medicine Chief of the Orbital and Ophthalmic VA Healthcare System Chief of the Ophthalmic Pathology Plastic Surgery Division Co-Director of Medical Student Division Director of the UCLA Orbital Disease Education at the David Geffen Center School of Medicine, UCLA Ophthalmic Pathology Co-Director of the UCLA Aesthetic Center Adult and Pediatric Glaucoma Dr. Glasgow specializes in ophthalmic pathology, and his research focus is Diseases and Therapy of the Dr. Giaconi’s areas of clinical specialty the role of human lacrimal gland pro- Eyelid and Orbit are adult and pediatric glaucoma and teins in the protection and maintenance cataract surgery. Her research inter- Dr. Goldberg is an internationally recog- of the eye. His laboratory is investi- ests are in the outcomes of glaucoma nized surgeon, researcher, and teacher. gating the structure-function relation- surgery. She also has a strong interest He has developed surgical procedures ship of tear lipocalin. By studying the in medical education. that are now globally taught and prac- molecular mechanisms of tear proteins, Dr. Giaconi provides clinical care ticed, including less invasive treatments Dr. Glasgow is seeking to learn the at the Stein Eye Institute in Westwood for eye and orbit cancers, new surger- normal functions of tear lipocalin and and at the Veterans Administration Eye ies for thyroid eye disease, and inno- its role in maintaining the health of the Clinic West Los Angeles campus. vative surgical techniques for tearing ocular surface and in the prevention of problems. His research into orbital and dry eye diseases. Ideally this research eyelid anatomy is resulting in improved will lead to new treatments for dry eye techniques and approaches to deep and have broad application to numer- orbital disease. He has had leadership ous other members of this protein fam- and executive positions in the Ameri- ily that transport small, insoluble mole- can Society of Ophthalmic Plastic and cules through the body. Reconstructive Surgery, the American Academy of Cosmetic Surgery, and the American College of Surgeons.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 41 FACULTY, UCLA STEIN EYE INSTITUTE

Lynn K. Gordon, MD, PhD Michael B. Gorin, MD, PhD Gary N. Holland, MD

Vernon O. Underwood Family Chair Harold and Pauline Price Chair Jack H. Skirball Chair in in Ophthalmology in Ophthalmology Ocular Inflammatory Diseases Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Senior Associate Dean for Equity and Professor of Human Genetics Director of the Ocular Inflammatory Diversity Inclusion, David Geffen Disease Center Chief of the Division of Retinal Disorders School of Medicine at UCLA and Ophthalmic Genetics Director of the UCLA Department of Chair of the College of Applied Anatomy, Ophthalmology Clinical Research Center David Geffen School of Medicine Co-Director of Medical Student Education at UCLA Hereditable Eye Disorders and Molecular Genetics of Age-Related Maculopathy Neuro-Ophthalmology and Uveitis and Cornea-External Ocular Diseases Inflammatory Disease Dr. Gorin’s clinical expertise is in medical retina and ophthalmic genetic dis- Dr. Gordon’s clinical specialty is neuro- Dr. Holland specializes in uveitis and orders. He has both a basic and trans- ophthalmology. Her research centers other inflammatory diseases of the eye. lation research program that address on inflammatory diseases of the eye His research activities focus on risk the genetics of inherited retinal dystro- and adnexa and the role of the four factors for, and clinical characteristics phies and age-related macular degen- transmembrane protein epithelial mem- of, various infectious and inflammatory eration, the biological basis of pain brane protein 2 in ocular and cancer diseases, including ocular toxoplas- caused by light exposure, the study of angiogenesis. Dr. Gordon is also the mosis, cytomegalovirus retinitis, and von Hippel Lindau disease, etiology of Senior Associate Dean for Equity and chronic anterior uveitis in children. central serous chorioretinopathy, drug Diversity Inclusion at the David Geffen Dr. Holland provides clinical care at and autoimmune-related retinopathies, School of Medicine at UCLA. the Stein Eye Institute in Westwood. genetics-based therapies for disease, Dr. Gordon provides clinical care in and late-life morbidities associated with neuro-ophthalmology at the Stein Eye retinopathy of prematurity. Institute in Westwood. Dr. Gorin was among the first UCLA physicians to be boarded in Clinical Informatics, and he is exploring the use and analysis of clinical datasets to better understand disease and clinical outcomes.

42 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Hamid Hosseini, MD Wayne L. Hubbell, PhD Jean-Pierre Hubschman, MD

Assistant Professor of Ophthalmology Jules Stein Chair in Ophthalmology Associate Professor of Ophthalmology Distinguished Professor Chief of Retina at Olive View-UCLA Retinal and Macular Conditions of Ophthalmology Medical Center Distinguished Professor of Director of the Advanced Robotic Dr. Hosseini specializes in retinal and Chemistry and Biochemistry Eye Surgery Laboratory macular conditions, such as macular Member of the Center for Advanced degeneration, diabetic retinopathy, and Molecular Basis of Phototransduction Surgical and Interventional Technology retinal detachment. in the Vertebrate Retina Member of the California NanoSystems Dr. Hosseini completed two fellow- Institute ships at the UCLA Stein Eye Institute, Dr. Hubbell’s research is focused on Affiliate Faculty of the the first in glaucoma and the second in understanding the relationship between Bioengineering Department retina. He participates in all activities of molecular structure, plasticity, and con- the Retina Division, including research, formational changes that control protein Advanced Vitreoretinal education, and clinical care. function in the visual system. Of partic- Surgical Interventions and Robotics He sees patients at the Stein Eye ular interest are proteins that behave as Institute in Westwood and Harbor- “molecular switches.” The overall goal Dr. Hubschman’s clinical research UCLA Medical Center. is to determine the structure of these focuses on the development and eval- proteins in their native environment, uation of new vitreoretinal surgical monitor the changes in structure that techniques and robotics for ophthalmic accompany the transition to an active surgery. Automated surgery utilizing state, and to understand the role of robotics promises to increase surgi- protein flexibility in function. cal precision and accuracy, as well To investigate these and other pro- as improve access to medical care. teins, Dr. Hubbell’s laboratory has devel- Dr. Hubschman’s publications include oped the technique of site-directed research papers on the development spin labeling, a novel and powerful of a new retinal patch for the treatment approach to the exploration of protein of retinal detachment, on the feasibility structure and dynamics. of robotic surgery in ophthalmology, and results of various clinical trials. Cur- rently, he is also investigating the use of the terahertz laser for the evaluation of ocular tissue hydration. Dr. Hubschman provides clinical care at the Stein Eye Institute in Westwood.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 43 FACULTY, UCLA STEIN EYE INSTITUTE

Simon K. Law, MD, PharmD Shawn R. Lin, MD Colin A. McCannel, MD

Health Sciences Clinical Professor Health Sciences Assistant Clinical Professor of Clinical Ophthalmology of Ophthalmology Professor of Ophthalmology Medical Director, Stein Eye Center– Medical Director, Stein Eye Santa Monica Optic Disc Evaluation Center–Calabasas Cataract and Refractive Surgery Dr. Law’s clinical specialties are glau- Vitreoretinal Surgery Specializing in cataract and refractive coma and cataract. His research activ- Dr. McCannel has a longstanding inter- surgery, Dr. Lin obtained his MD and ities include evaluation of the optic est in the management of vitreoreti- MBA from Stanford University. He con- nerve in different racial groups and nal conditions, particularly complex ducted his ophthalmology residency at ocular pathologies, different patterns of retinal detachments, complications the UCLA Stein Eye Institute, and he glaucomatous visual function decline, of diabetic retinopathy, macular holes completed a Heed Cornea Fellowship outcomes of different glaucoma sur- and epimacular membranes, and age- at the Massachusetts Eye and Ear Infir- gical procedures and medications in related macular degeneration. His clin- mary at Harvard University. eye pressure control and vision resto- ical research efforts are directed at the Dr. Lin’s research is focused on com- ration, and alternative therapy in glau- improvement of vitreoretinal surgical bining human and artificial intelligence coma care. techniques and outcomes, including to deliver exceptional surgical results. Dr. Law provides clinical care at the the prevention of endophthalmitis fol- He has authored more than a dozen Stein Eye Institute in Westwood. lowing intravitreal injections. peer-reviewed publications in leading Dr. McCannel devotes time to edu- ophthalmology journals, has written cational research as well. Currently, he chapters on ophthalmology and cor- is investigating the utility of virtual real- nea for textbooks, and has delivered ity surgery simulation in teaching oph- keynote presentations at international thalmic surgery. He has several ongo- scientific meetings. ing protocols that assess ophthalmic Dr. Lin founded EyeGuru, an online surgical simulation in surgical teaching. educational platform visited more than Dr. McCannel provides clinical care 300,000 times a year by ophthalmol- at the Stein Eye Institute in Westwood ogists from 125 countries. In this role, and the Stein Eye Center–Santa Monica. Dr. Lin helps to advance knowledge in the field and train the next generation of ophthalmologists. Dr. Lin sees patients at the Stein Eye Institute in Westwood and the Stein Eye Center–Calabasas.

44 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Tara A. McCannel, MD, PhD Kevin M. Miller, MD Kouros Nouri-Mahdavi, MD, MSc Health Sciences Clinical Professor Kolokotrones Chair in Ophthalmology of Ophthalmology Professor of Clinical Ophthalmology Associate Professor of Ophthalmology Director of the Ophthalmic Oncology Chief of the Cataract and Refractive Director of the Glaucoma Advanced Center Surgery Division Imaging Laboratory Director of the Anterior Segment Metastatic Ocular Melanoma and Diagnostic Laboratory Role of Structural and Functional Diseases of the Retina and Vitreous Measurements for Detection of Dr. McCannel is an ophthalmic oncolo- Cataract and Refractive Surgery Glaucoma and Its Progression gist, as well as a vitreoretinal surgeon. Dr. Miller is chief of the Cataract and Dr. Nouri-Mahdavi’s areas of clinical Dr. McCannel’s Ophthalmic Oncology Refractive Surgery Division and direc- interest are management of adult Laboratory is studying molecular mark- tor of the Anterior Segment Diagnos- glaucoma and complex cataract sur- ers in ocular melanoma to provide tic Laboratory. His research interests gery. His research activities include prognostic information to patients and include devices and implants used in optimizing the role of structural and advance understanding of metastatic cataract and refractive surgery, out- functional measurements for detec- disease. Discovery of candidate genes comes of surgical procedures, astig- tion of glaucoma and its progression from tissue of patients undergoing sur- matism management, and artificial iris with an emphasis on advanced dis- gical treatment for ocular melanoma is implantation. ease and macular optical coherence being explored. This information will be Dr. Miller provides patient care in tomography imaging. More recently, his important to establish a better under- the Cataract and Refractive Surgery research laboratory has been explor- standing of the biology of metastatic Suite on the second floor of the Edie ing the use of artificial intelligence in ocular melanoma and help develop and Lew Wasserman Building at the glaucoma diagnostics. Another area of better treatments for this cancer. New Stein Eye Institute. interest is the study of glaucoma surgi- modalities are being investigated to cal outcomes. predict, detect, and ultimately treat Dr. Nouri-Mahdavi provides clin- choroidal melanoma metastasis. ical care at the Stein Eye Institute in Dr. McCannel provides clinical care Westwood, as well as the Stein Eye at the Stein Eye Institute in Westwood. Center–Calabasas and the Stein Eye Center–Santa Monica.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 45 FACULTY, UCLA STEIN EYE INSTITUTE

Steven Nusinowitz, PhD Yirong Peng, PhD Stacy L. Pineles, MD

Professor of Ophthalmology Assistant Professor of Ophthalmology Jerome and Joan Snyder Chair in Ophthalmology Co-Director of the Visual Physiology Laboratory Pathogenesis of Retinal Diseases Associate Professor of Ophthalmology Director of the Live Imaging and Residency Director, Department Functional Evaluation (LIFE) Core Dr. Peng is a neuroscientist whose of Ophthalmology research focuses on large-scale transcriptomic profiling of retinal cells in Mechanisms of Retinal Pediatric Neuro-Ophthalmology, healthy and pathological conditions to Degeneration Amblyopia, and Neurologic Causes understand human vision and provide of Strabismus Dr. Nusinowitz is a visual physiologist insights for the study of ocular diseases. whose primary research interest is the Dr. Peng received her PhD in neuro- Dr. Pineles’ research interests include study of the sites and mechanisms of biology from the Institute of Neurosci- evaluating the surgical outcomes of disease action in inherited eye dis- ence, Chinese Academy of Sciences, strabismus surgery and studying pedi- eases. He is focused on understanding Shanghai, China. Her doctoral research atric optic nerve diseases. With her dual the cellular contributions to noninva- examined the role of functional interac- training in pediatric ophthalmology and sive measures of visual function and tions between inhibitory and excitatory neuro-ophthalmology, she has a special defining the sites and mechanisms synapses that maintain the stability of interest in pediatric neuro-ophthalmic of disease action in inherited retinal neural networks. Dr. Peng then joined diseases, as well as adult patients with and visual pathway disorders. By test- the laboratory of Dr. Joshua Sanes amblyopia and neurologic causes of ing hypotheses about the underlying at Harvard University as a postdoc- strabismus. pathophysiology in human disease, toral fellow, where she leveraged high Dr. Pineles provides clinical care at Dr. Nusinowitz hopes to provide a throughput single-cell transcriptomic the Stein Eye Institute in Westwood. mechanism for the development of methods to uncover key transcriptional specific diagnostic tools that are suf- factors that control the specification of ficiently sensitive for early detection retinal cell types. and better diagnosis of clinical disease. At Stein Eye, Dr. Peng is continuing her development of state-of-the-art transcriptomic and genomic tools to reveal the molecular underpinnings of the formation of retinal circuits and the pathogenesis of retinal diseases.

46 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Natik Piri, PhD Pradeep S. Prasad, MD, Roxana A. Radu, MD MBA Professor of Ophthalmology Assistant Professor of Ophthalmology Health Sciences Associate Clinical Retinal Ganglion Cell Biology, Professor of Ophthalmology Retina Biochemistry and Clinical Glaucomatous Neurodegeneration, Chief, Division of Ophthalmology, Disease Modeling Laboratory and Neuroprotection Harbor-UCLA Medical Center Dr. Radu’s scientific interest is to Dr. Piri’s primary research is defining the understand the mechanism of pho- Vitreoretinal Surgery and mechanisms leading to retinal ganglion toreceptor cell degeneration by inte- Disease Management cell (RGC) degeneration in glaucoma- grating genetic, biochemical, cellular, tous neuropathy; developing strategies Dr. Prasad specializes in the medical and molecular approaches. Dr. Radu’s for preserving RGCs against neurode- and surgical management of diseases research focuses on the formation and generation; and identifying and char- of the retina and vitreous. His research pathogenic role of bisretinoids in reti- acterizing the genes critical for RGC is focused on teleretinal screening for nopathies such as recessive Stargardt function and integrity. Characterization diabetic retinopathy, applications of disease and age-dependent macu- of RGC-expressed genes is fundamen- wide-field fundus photography for ret- lar degeneration. Her group aims to tal to a better understanding of normal inal vascular disease, and health care develop disease experimental models RGC physiology and pathophysiology. delivery for low-income populations. to investigate the bisretinoid-mediated Dr. Piri also focuses on understand- Dr. Prasad serves as the chief of the complement dysregulation in the retinal ing the degeneration of RGCs and their Division of Ophthalmology at Harbor- pigment epithelium as a key player in axons, which is a hallmark of glaucoma. UCLA Medical Center where he pro- visual loss. Her studies are supported He is also studying the involvement vides clinical supervision and instruc- by the NIH, private foundations, and of oxidative stress and proteins of the tion to UCLA medical students as well philanthropic funds. Dr. Radu is also thioredoxin system, particularly in RGC as to Stein Eye residents and vitreo- actively involved in training and teach- degeneration in the glaucoma model, retinal fellows. ing undergraduates, postgraduate fel- and the neuroprotective effects of lows, and medical students. these proteins against glaucomatous RGC death.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 47 FACULTY, UCLA STEIN EYE INSTITUTE

Alapakkam P. Sampath, PhD David Sarraf, MD Steven D. Schwartz, MD

Professor of Ophthalmology Health Sciences Clinical Professor The Ahmanson Chair in Ophthalmology and Neurobiology of Ophthalmology Professor of Ophthalmology Associate Director, Stein Eye Institute Chief of the Retina Division Chief, Vision Science Division Age-Related Macular Degeneration Director of the UCLA Diabetic and Retinal Imaging Eye Disease and Retinal Vascular Center Molecular Mechanisms Underlying Dr. David Sarraf is clinical professor of Director of the Macula Center Early Visual Processing ophthalmology at the UCLA Stein Eye Institute and member of the Retinal The Sampath laboratory is interested Retinal Diseases and Disorders and Ophthalmic Genetics in understanding the molecular mech- Stem Cell Research Division. He has published approxi- anisms underlying early visual process- mately 250 peer-reviewed research Dr. Schwartz’s primary areas of research ing. In particular, the focus of laboratory papers, case reports, and reviews and include early diagnosis and treatment researchers has been on elucidating has authored 21 book chapters and is of diseases such as retinopathy of pre- mechanisms that set the sensitivity of co-author for the second edition of The maturity, diabetic eye disease, and night vision. Night blindness, or nycta Retina Atlas and will be section editor macular degeneration. Dr. Schwartz’s lopia, is a condition that results from for the 7th edition of Ryan’s Retina . research includes evaluation of meth- abnormal signaling by the rod photo- Dr. Sarraf is a world leader in the field ods to measure optic nerve damage, receptors, or the retinal circuits that of advanced retinal imaging and has and the role of structural and functional process rod-driven signals. Using phys- delivered close to 300 invited lectures measurements for detection of glau- iological and genetic methods, the lab- at meetings worldwide, including sev- coma and its progression. Dr. Schwartz oratory studies signal transmission in eral endowed and keynote lectures. also leads clinical trials testing the use these retinal rod pathways to identify Dr. Sarraf’s focus of research inter- of stem cells to address vision loss how these processes are optimized to est is in the field of advanced retinal from Stargardt macular dystrophy and allow our exquisite visual sensitivity. imaging. He has been a pioneer in the dry age-related macular degeneration. clinical application of OCT angiography Dr. Schwartz provides clinical care and is a world expert on OCTA and at the Stein Eye Institute in Westwood. OCT imaging of the macula. Dr. Sarraf was nominated to the American Oph- thalmological Society because of his research work on the subject of AMD.

48 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Soh Youn Suh, MD Hui Sun, PhD Gabriel H. Travis, MD

Health Sciences Clinical Instructor Professor of Physiology and Charles Kenneth Feldman Chair Ophthalmology in Ophthalmology Pediatric Ophthalmology and Member of Jonsson Comprehensive Professor of Ophthalmology Cancer Center Adult Strabismus Biochemistry of Vertebrate Dr. Suh’s clinical specialties are pedi- Molecular Mechanism of Vitamin A Photoreceptors and Mechanisms of atric ophthalmology and adult strabis- Transport for Vision; Identification Retinal Degeneration mus. Her research interests include of New Therapeutic Targets for evaluating strain on the optic nerve Blinding Diseases Dr. Travis’ laboratory uses biochemical head and globe displacement during and genetic approaches to study the horizontal ductions in patients and Dr. Sun’s laboratory aims to identify visual cycle and its role in retinal and normal controls using magnetic reso- new therapeutic targets to treat still macular degenerations. Vision in ver- nance imaging and optical coherence incurable human diseases, to study tebrates is mediated by two types of tomography. their molecular mechanisms, and to light-sensitive cells: rods and cones. Dr. Suh provides clinical care at the develop novel therapies based on These cells contain light-detecting mol- Stein Eye Institute in Westwood and the mechanisms. Through many years ecules called opsin pigments. Detec- Olive View-UCLA Medical Center. of research efforts, his laboratory has tion of a single light particle bleaches identified the cell-surface receptors for the opsin pigment. Restoring light sen- the most potent endogenous inhibitor sitivity to a bleached opsin involves an of angiogenesis, developed novel tech- enzymatic pathway called the visual niques to screen for drugs that target cycle. Mutations in the genes for many these receptors, and developed the proteins of the visual cycle cause inher- first small molecule drug candidates ited blinding diseases. that specifically suppress pathogenic angiogenesis in diverse vision diseases and in cancer. These molecules have achieved therapeutic effects that no existing drugs can achieve and are being prepared for clinical trials.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 49 FACULTY, UCLA STEIN EYE INSTITUTE

Edmund Tsui, MD Irena Tsui, MD Soheab Ugradar, MD

Assistant Professor of Ophthalmology Associate Professor of Ophthalmology Health Sciences Clinical Instructor

Uveitis and Ocular Inflammatory Clinical Vitreoretinal Research Orbital and Ophthalmic Diseases Plastic Surgery Dr. Tsui’s clinical activities include adult Dr. Tsui specializes in the management and pediatric vitreoretinal diseases. Dr. Ugradar came to Stein Eye from of uveitis and ocular inflammatory dis- Her research interests focus on reti- London, England, as an international eases. He completed his medical train- nopathy of prematurity and Zika virus fellow specializing in orbital and ophthal- ing at Dartmouth Medical School fol- eye abnormalities. Dr. Tsui teaches mic plastic surgery. He conducted his lowed by an ophthalmology residency ophthalmology trainees and serves ophthalmology residency at Moorfields at the New York University School of veterans at the Greater Los Angeles Eye Hospital, where he is still an hon- Medicine. He completed his fellow- VA Healthcare System. orary research fellow. Dr. Ugradar was ship in uveitis and ocular inflammatory Dr. Tsui provides clinical care at the ranked number one in the UK National disease at the Francis I. Proctor Foun- Stein Eye Institute in Westwood and Recruitment for Ophthalmology and is dation at the University of California, the Doheny Eye Center UCLA–Arcadia. the recipient of numerous academic San Francisco. scholarship awards and honors for his Dr. Tsui’s research focuses on the research, including the Ophthalmology evaluation of imaging biomarkers to Research Gold Medal UK, the Bernice measure and quantify intraocular inflam- Brown Fellowship Award, the Young mation with optical coherence tomog- European researcher’s award, and the raphy and laser flare photometry. He Drapers’ Company Prize for outstanding serves on the Association for Research achievement at an undergraduate level. in Vision and Ophthalmology Continu- Dr. Ugradar regularly presents at interna- ing Medical Education Committee and tional conferences and is a reviewer for the Advocacy and Outreach Commit- multiple journals in the field of oculoplas- tee. He is also a social media editor for tics. His research has led to inventions the journals Ophthalmology, Ophthal- that are currently under patent. mology Retina, and Ophthalmology Dr. Ugradar sees patients at the Glaucoma. Stein Eye Institute in Westwood, as well Dr. Tsui provides care to patients at as the Stein Eye Center–Calabasas and the Stein Eye Institute in Westwood. the Stein Eye Center–Santa Monica.

50 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues David S. Williams, PhD Xian-Jie Yang, PhD Jie J. Zheng, PhD

Karl Kirchgessner Foundation Chair in Ernest G. Herman Chair Professor of Ophthalmology Vision Science in Ophthalmology Member of the Molecular Biology Professor of Ophthalmology Professor of Ophthalmology Institute and Neurobiology Member of the Jonsson Comprehensive Development and Disease Therapy Cancer Center Cell Biology of the Retina and of the Retina Member of the Brain Research Institute Inherited Retinal Disease Dr. Yang’s research is focused on Member of the California NanoSystems Institute Dr. Williams’ laboratory focuses on molecular mechanisms of retina de- the cell biology of photoreceptor and velopment and repair. Her research retinal pigment epithelium cells. His approaches include using genetically Therapeutic Development group is especially interested in pro- engineered retinal degeneration mod- in Ophthalmology teins that function in transport and com- els, recombinant virus mediated gene Dr. Zheng’s research is at the interface partmentalization within these cells. delivery, and human pluripotent stem of biochemistry, computational biology, These proteins include those that cell-derived retinal neurons to simulate systems pharmacology, and drug dis- underlie Usher syndrome and macu- human diseases. covery with an emphasis on therapeutic lar degeneration. Translational areas Dr. Yang’s research laboratory is development in ophthalmology. of his research involve gene therapy located at the Stein Eye Institute in His laboratory is currently devel- experiments aimed at preventing the Westwood. Her research activities oping proteins and small molecules blindness that ensues from Usher syn- are support by NIH grants and institu- that can modulate signal transduction drome type 1B and studies on stem tional support. pathways, such as Wnt, Hedgehog, cell-derived RPE cells, which may be BMP, and Hippo pathways, in an effort transplanted into retinas afflicted by to better understand the biological macular degeneration. functions of these signaling pathways and to explore the therapeutic potential of these compounds and proteins. Aiming to establish new translational research within the scientific community at UCLA, Dr. Zheng’s goal is to develop novel therapies for retinal degenerative diseases, glaucoma, and corneal disorders.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 51 FACULTY, DOHENY EYE CENTERS UCLA

Steven A. Barnes, PhD Benjamin B. Bert, MD Vikas Chopra, MD

Professor of Ophthalmology Health Sciences Assistant Clinical Charles Stewart Warren and Professor of Ophthalmology Hildegard Warren Endowed Research Chair Ion Channel Function in Cornea-External Ocular Disease and Health Sciences Associate Clinical Retinal Neurons Professor of Ophthalmology Refractive Surgery Dr. Barnes is a neurobiologist inter- Medical Director, ested in how the retinal milieu in healthy Dr. Bert provides comprehensive oph- Doheny Eye Center UCLA–Pasadena and stressed states affects ion chan- thalmic care and is a subspecialist in nels that mediate signaling within and cornea/external disease. His areas Glaucoma between retinal neurons. The activity of expertise include: dry eye/blepha of ion channel proteins in retinal neuritis, conjunctivitis, uveitis, acute cor- Specializing in glaucoma, Dr. Chopra’s rons governs how the retinal network neal injury, and genetic corneal dis- research activities include advanced optimizes image processing. Dr. Barnes orders, as well as cataract surgery optic nerve and retinal nerve fiber layer seeks to define targets that could aid with advanced intraocular lenses and imaging for early glaucoma detection, precision interventions in slowing or refractive surgery. as well as development and validation preventing vision loss in diseases such Dr. Bert sees patients at the Doheny of novel parameters for use in anterior as glaucoma and macular degenera- Eye Center UCLA offices in Orange segment optical coherence tomogra- tion. Important questions concern the County and Pasadena. phy devices as principal investigator limits that the bioenergetic environment at the Doheny Image Reading Center. puts on photoreceptor and ganglion Dr. Chopra also evaluates laser and sur- cell sensitivity and signaling capabili- gical techniques for the management ties, as well as how early stages of this of glaucoma. dysfunction are manifested. Dr. Chopra provides patient care at the Doheny Eye Center UCLA locations in Arcadia and Pasadena.

52 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Brian A. Francis, MD, MS Kaustabh Ghosh, PhD Gad Heilweil, MD

Rupert and Gertrude I. Stieger Associate Professor of Ophthalmology Health Sciences Assistant Clinical Vision Research Chair Professor of Ophthalmology Health Sciences Clinical Professor Vascular Inflammation, of Ophthalmology Mechanobiology, Bioengineering, Degenerative Retinal Disease Director of Glaucoma Services, and Nanomedicine Doheny Eye Centers UCLA Dr. Heilweil’s research activities include stem-cell therapy for degenerative Medical Director, Doheny Eye Center Dr. Ghosh is an interdisciplinary re UCLA–Orange County searcher with expertise in vascular retinal disease; retinal and uveal drug inflammation, mechanobiology, bio toxicity; and pharmacokinetics of intra- engineering, and nanomedicine. vitreal drugs. Glaucoma He obtained his undergraduate In addition to providing patient care Dr. Francis’ clinical specialties are degree in chemical engineering from at the Stein Eye Institute in Westwood glaucoma and complex cataract. His the National Institute of Technology, and the Stein Eye Center–Calabasas, research activities include: innovative India; his PhD in biomedical engineer- Dr. Heilweil sees patients at the Doheny glaucoma surgeries, minimally inva- ing from Stony Brook University, New Eye Center UCLA locations in Arcadia, sive glaucoma surgery, novel visual York; and conducted his postdoctoral Orange County, and Pasadena. field techniques, glaucoma diagnos- fellowship in the Vascular Biology Pro- tic and functional imaging, anterior gram at Boston Children’s Hospital and segment imaging (ultrasound biomi- Harvard Medical School. croscopy and Fourier domain optical Dr. Ghosh was associate profes- coherence tomography), and glaucoma sor of bioengineering at the Univer- laser surgery. sity of California, Riverside (UCR), and Dr. Francis sees patients at the participating faculty in the UCR Divi- Doheny Eye Center UCLA locations in sion of Biomedical Sciences, Stem Arcadia, Orange County, and Pasadena. Cell Center, and the Program in Cell, Molecular and Developmental Biology. The Ghosh Research Group at UCR focused on leveraging the principles of mechanobiology to examine and treat inflammation-mediated vascular degeneration associated with diabetic retinopathy and age-related macular degeneration. Dr. Ghosh has active R01 grants from the National Eye Institute and was recently honored as Featured Scientist by the BrightFocus Foundation.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 53 FACULTY, DOHENY EYE CENTERS UCLA

Hugo Y. Hsu, MD Alex A. Huang, MD, PhD Michael S. Ip, MD

Health Sciences Clinical Professor Assistant Professor of Ophthalmology Gavin S. Herbert Endowed Chair for of Ophthalmology Macular Degeneration Glaucoma Professor of Ophthalmology Cornea and External Diseases Service Chief, Doheny Retina Division Dr. Huang’s clinical specialties are Dr. Hsu specializes in corneal infection in complex cataract and glaucoma Medical Director, Doheny Image Reading Center and inflammation, corneal transplanta- surgery. His research is dedicated to tion, anterior segment reconstruction, understanding fluid flow in the eye to and cataract surgery. His research improve and customize glaucoma sur- Vitreoretinal Disease interests include corneal and ocular gery. He also studies ocular changes Dr. Ip is the chief of the Vitreoretinal infections and ophthalmic antibiotics. that American astronauts experience Surgery Service at the Doheny Eye Dr. Hsu sees patients at the Doheny in Space. Centers UCLA. His practice concen- Eye Center UCLA locations in Arcadia, Dr. Huang provides clinical care at the trates on the surgical management of Orange County, and Pasadena. Doheny Eye Center UCLA–Pasadena. complex retinal detachment, complications of diabetic retinopathy, macular holes, epiretinal membranes, and other vitreoretinal diseases amenable to surgical intervention. Dr. Ip’s research focuses on the design and conduct of clinical trials investigating treatments for diabetic retinopathy, age-related macular degeneration, and retinal venous occlusive disease. As medical director for the Doheny Image Reading Center, end- point analysis for clinical trials is an additional area of research focus. In addition, Dr. Ip has served as the national director for numerous NIH- funded ophthalmic clinical trials.

54 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues John A. Irvine, MD Ram Kannan, PhD Monica R. Khitri, MD

A. Ray Irvine, Jr., MD, Adjunct Professor of Ophthalmology Health Sciences Assistant Clinical Chair in Clinical Ophthalmology Professor of Ophthalmology Health Sciences Clinical Professor Eye Physiology and Pathology of Ophthalmology Pediatric Ophthalmic Diseases Medical Director, Dr. Kannan’s research focuses on eye and Strabismus Doheny Eye Centers UCLA physiology and pathology. He currently investigates age-related mac- Dr. Khitri specializes in the evaluation and treatment of pediatric ophthalmic Cornea and External Diseases ular degeneration, a leading cause of blindness in high-resource countries. diseases, including pediatric cataracts, Dr. Irvine’s clinical specialties are cor- nasolacrimal duct obstructions, amblyo- nea and external diseases (eg, tumors, pia, and retinopathy of prematurity. She infections), anterior segment surgical also treats and operates on strabismus consultation, and prosthetic replace- in both children and adults. ment of the ocular surface ecosystem She received her medical degree (PROSE). His research activities focus from the David Geffen School of Med- on ocular infections. icine at UCLA and completed her res- Dr. Irvine provides patient care at idency in ophthalmology at the Stein the Doheny Eye Center UCLA loca- Eye Institute, followed by a fellowship tions in Arcadia, Orange County, and in pediatric ophthalmology and stra- Pasadena. bismus at the Children’s Hospital of Philadelphia. Dr. Khitri is also a medical educator, researcher, and winner of over two dozen academic and professional awards, including the 2018 Faculty Teaching Award for the Stein Eye Insti- tute ophthalmology residency program. Dr. Khitri sees patients at the Doheny Eye Center UCLA locations in Arcadia, Pasadena, and Orange County. She also teaches residents and fellows at Harbor-UCLA Medical Center, where she is chief of the Pediatric Ophthal- mology Service.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 55 FACULTY, DOHENY EYE CENTERS UCLA

Olivia L. Lee, MD Kenneth L. Lu, MD Peter A. Quiros, MD

Health Sciences Assistant Clinical Health Sciences Assistant Clinical Health Sciences Associate Clinical Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Medical Director, Cornea/External Diseases and Doheny Eye Center UCLA–Arcadia Neuro-Ophthalmology Uveitis; Corneal Imaging A neuro-ophthalmologist, Dr. Quiros Cataract and Refractive Surgery Focusing on cornea/external diseases specializes in optic nerve disease, and uveitis, Dr. Lee’s particular interest Dr. Lu specializes in cataract and refrac- including optic neuritis and multiple is in inflammatory ocular surface dis- tive surgery, and his research activities sclerosis; double vision and adult ease, corneal melts, pterygia, and ante- are focused in the same areas. strabismus; eye pain, headache, and rior segment complications of uveitis. Dr. Lu sees patients at the Doheny idiopathic intracranial hypertension; Dr. Lee performs all types of corneal Eye Center UCLA–Arcadia. Graves disease; orbital inflammatory transplants, as well as complex cata- syndromes; and stroke. Research in ract surgery in uveitic eyes. cludes idiopathic intracranial hyper- Dr. Lee’s research interests are ante- tension, headache, ocular myasthenia rior segment imaging applied to the gravis, Graves disease, optic neuri- tear film, cornea, and conjunctiva. With tis and multiple sclerosis, and visual her expertise in corneal imaging, a rehabilitation after stroke. He was the specular microscopy reading center principal investigator for the idiopathic was developed at the Doheny Image intracranial hypertension treatment Reading Center, where she serves as trial and is the principal investigator for an investigator. the longitudinal idiopathic intracranial Dr. Lee provides patient care at hypertension treatment trial. He is a the Doheny Eye Center UCLA loca- member of the Neuro-Ophthalmology tions in Arcadia, Orange County, and Researcher and Disease Investigators Pasadena. Consortium. Dr. Quiros sees patients at the Doheny Eye Center UCLA locations in Orange County and Pasadena.

56 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Daniel B. Rootman, MD, MS SriniVas R. Sadda, MD Alfredo A. Sadun, MD, PhD

Karen and Frank Dabby Endowed Chair Stephen J. Ryan-Arnold and Flora L. Thornton Endowed Chair in Ophthalmology Mabel Beckman Foundation in Vision Research Endowed Presidential Chair Assistant Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Vice Chair, Doheny Eye Centers UCLA Orbit and Ophthalmic President and Chief Scientific Officer, Doheny Eye Institute Plastic Surgery Neuro-Ophthalmology Dr. Rootman is an orbit and ophthalmic Retinal and Macular Diseases Dr. Sadun conducted his ophthalmol- plastic surgery specialist with exper- ogy residency and fellowship in neuro- Dr. Sadda received his MD from Johns tise in Graves disease, orbital surgery, ophthalmology at Massachusetts Eye Hopkins University, where he also com- orbital tumors, ptosis, lacrimal disor- and Ear, Harvard Medical School. His pleted his ophthalmology residency ders, blepharoplasty, blepharospasm, clinical interests are diseases of the and neuro-ophthalmology and medical Botox®, cosmetic dermal fillers, endo- optic nerve, and more particularly, retina fellowships. His clinical interests scopic eyebrow lift, eyelid surgery, Leber hereditary optic neuropathy, are macular degeneration and diabetic eyelid tumors, and trauma. His research toxic and nutritional optic neuropa- retinopathy and his research includes is developing and refining patient- thies, and anterior and posterior ische automated retinal image analysis and centered outcome measures for sur- mic optic neuropathies. He conducts advanced retinal imaging technologies. gical care; randomized clinical trials in research in these areas, as well as the He has more than 550 peer-reviewed surgery, including ptosis, Graves orbi- assessment of the retina and optic publications and 20 book chapters, topathy and lacrimal disease; health nerve in Alzheimer disease and other and has given over 450 presentations economics of eyelid and facial surgery; neuro-degenerations. Dr. Sadun has worldwide. He also serves as an edi- sociodemographics of facial trauma; authored approximately 400 peer- torial board member of Ophthalmic physiology and pathobiology of ptosis; reviewed publications and 25 book Surgery, Lasers & Imaging, Retina, new approaches to surgery; and mea- chapters. His research activities focus Graefe’s, Ophthalmology Retina, and surement and assessment in medical on human visual neuro-anatomy; ret- Ophthalmology. He is also an editor education. inal ganglion cell degeneration and of the 5th edition of the Ryan’s Retina Dr. Rootman sees patients at the regeneration; and axon populations in textbook. Stein Eye Institute in Westwood and the the human optic nerve in development, Dr. Sadda provides clinical care at the Doheny Eye Center UCLA locations in aging, and disease. He has six clinical Doheny Eye Center UCLA in Pasadena Orange County and Pasadena. trials involving treatment of optic nerve and Arcadia. diseases, and most particularly, mito chondrial impairments as a cause of optic nerve disease. Dr. Sadun sees patients at the Doheny Eye Center UCLA–Pasadena.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 57 FACULTY, DOHENY EYE CENTERS UCLA

Deming Sun, MD James C. Tan, MD, PhD Yuhua Zhang, PhD

Mary D. Allen Chair in Vision Research Associate Professor of Ophthalmology Associate Professor of Ophthalmology Professor of Ophthalmology Glaucoma Retinal Imaging Research Scientist Dr. Tan is a dual fellowship-trained Dr. Zhang is an optical engineer and ret- Dr. Sun is a researcher whose primary glaucoma specialist. He treats the full inal imaging specialist, whose research areas of investigation include uveitis, spectrum of cataract and glaucoma encompasses state-of-the-art tools to autoimmune diseases, optic neuri- conditions, ranging from mild to com- study blinding eye disorders, including tis, animal disease models, and T-cell plex. His treatments and surgeries next-generation 3-D imaging technol- biology. focus on safe and effective outcomes ogy for viewing the retina in patients using advanced techniques. Dr. Tan has with age-related macular degeneration authored over 100 scientific papers, at the cellular level. abstracts, book chapters, and books. His technology integrates adaptive His glaucoma research addresses optics, scanning laser ophthalmoscopy, advanced imaging, molecular patho- and optical coherence tomography to genesis, drug development, and surgi- study the vision-producing cells and cal techniques. He has received awards tiniest blood vessels of the eye. Under- from the National Institutes of Health, standing their interplay will help answer Research to Prevent Blindness, and the questions about causes of vision loss, American Glaucoma Society. improve prognoses for patients, and Dr. Tan provides patient care at the lead to directed treatments to slow or Doheny Eye Center UCLA locations in prevent vision loss. Arcadia and Pasadena.

58 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues ACADEMIC PERSONNEL

Stein Eye Institute Members Professional Research Series Based at Other Sites Christian Altenbach, PhD James W. Bisley, PhD Antoni Ribas, MD, PhD Research Ophthalmologist Professor of Neurobiology Professor of Medicine, Surgery, and Structure and Function and Psychology Molecular and Medical Pharmacology of Rhodopsin Member of the Brain Research Institute Malignant Melanoma The membrane protein rhodopsin is Cognitive Processing of Dr. Ribas is a physician-scientist who a critical first step in visual transduc- Visual Information conducts laboratory and clinical re tion, converting light energy into a Dr. Bisley’s research revolves around search in malignant melanoma, focus- chemical form in the photoreceptor understanding the neural mechanisms ing on gene engineered adoptive cell cell of the eye. To understand this pro- underlying the cognitive processing transfer (ACT) therapies, anti-CTLA4 cess on a detailed molecular level, Dr. of visual information. These cognitive antibodies, anti-PD-1 antibodies, and Altenbach is using site-directed spin processes include visual perception, BRAF and MEK inhibitors. labeling and electron paramagnetic visual memory, visual attention, and resonance spectroscopy to study the the visual guidance of eye movements. structure of rhodopsin in the absence Recent work has focused on how the Dario L. Ringach, PhD of light, as well as the changes in struc- responses of neurons in the posterior Professor of Neurobiology ture caused by light. and Psychology, parietal cortex and prefrontal cortex are Biomedical Engineering Program involved in the allocation of visual attention and how they guide eye move- Visual Perception and Michael Bridges, PhD ments in goal-directed visual search. Neurophysiology Assistant Project Scientist Dr. Ringach’s research focuses on the Paramagnetic Resonance Methodologies Patrick T. Dowling, MD, MPH relationship between eye movements and visual perception, as well as how Dr. Bridges’ research in the laboratory Chair, UCLA Department of motor planning and execution, such Family Medicine of Dr. Wayne Hubbell is centered on as reaching, grasping, navigating, and the development and application of The Kaiser Endowed Professor of adjusting body posture, is influenced Community Medicine new pulsed electron paramagnetic by visual information and impaired resonance methodologies. Protein con- Health Care Policy and Access for vision. In collaboration with a team of formational dynamics and structural Underserved Populations neurosurgeons at UCLA, Dr. Ringach’s relaxation are his central focus with the Dr. Dowling has received grant funding laboratory is also recording the brain goal of characterizing the timescales for more than 30 years to link medi- activity of patients with epilepsy who and motional amplitudes of functional cal education to underserved neigh- are undergoing clinical evaluation for activation. borhoods thereby providing access surgical treatment, shedding new light to care. Further, he has worked with into the processes involved in object Dr. Anne Coleman and the Care Harbor recognition and perception. Barry L. Burgess, BS program to provide free medical, den- Research Specialist tal, and eye care to 3,500 low-income Degenerative Retinal Disease families, and the medically indigent of Research Los Angeles. Mr. Burgess provides research support for the Photoreceptor/RPE Cell Biol- ogy Laboratory of Dr. David Williams. Research interests include production of differentiated RPE cells from human stem cell precursors and developing in vitro models of oxidative stress involved in degenerative retinal disease progression.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 59 ACADEMIC PERSONNEL

Doug Chung, PhD Rajendra Gangalum, PhD Joanna J. Kaylor, PhD Assistant Project Scientist Assistant Research Specialist Associate Project Scientist Corneal Endothelial Dystrophies Function and Regulation of Visual Chromophore Regeneration Small Heat Shock Protein in the Retina of the Eye Dr. Chung’s research focus is eluci- aB-crystallin in Health and Disease dating the mechanisms involved in Dr. Kaylor has discovered that light the pathogenesis of inherited corneal Dr. Gangalum’s research seeks to gain plays a vital role in regeneration of endothelial dystrophies in an effort to understanding of the physiological visual chromophore in the retina. She develop novel gene-based therapeutic function of aB-crystallin in the devel- recently identified a non-enzymatic approaches. oping ocular lens and non-ocular tis- process that generates visual pigment sues. aB-crystallin has been shown in photoreceptor membranes in light. to associate with pathologies such as Her research now focuses on the func- Matthias Elgeti, PhD cataracts, cancer, age-related macu- tion of retinal G-protein coupled recep- Assistant Project Scientist lar degeneration, and various neuro tor (RGR). degenerative diseases. Development of Common Structure/Function Relationships Jacky M. K. Kwong, PhD of GPCR Activation Based on the Sheyla Gonzalez Garrido, Rhodopsin Model System Research Ophthalmologist PhD Dr. Elgeti’s work focuses on the activa- Degeneration of Retinal Ganglion Assistant Project Scientist Cells and Neuroprotection tion mechanisms of G protein coupled receptors (GPCRs), which are involved Limbal Stem Cells Dr. Kwong identifies novel neuropro- in many cellular signaling processes Dr. Gonzalez’s research aims to improve tective and regenerative therapies for and represent major drug targets. He the ex vivo expansion of limbal epithe- glaucoma that preserve and restore addresses his questions by comparing lial stem cells (LSCs) by modulating the nerve cells. He utilizes animal mod- visual rhodopsin with other prototypical Notch signaling in individuals suffering els related to optic nerve injury and GPCRs using site-directed spin label- from limbal stem cell deficiency. The glaucoma to understand the progres- ing (SDSL) and electron paramagnetic identification of niche factors could sion of retinal ganglion cell degener- resonance (EPR) spectroscopy. help to improve the in vitro production ation, and pharmacologic techniques of LSCs for transplantation. and functional assessments to evaluate therapies. Rikard Frederiksen, PhD Assistant Research Ophthalmologist Sonia Guha, PhD Anna Matynia, PhD Adaptation Assistant Project Scientist Associate Research Ophthalmologist Dr. Frederiksen’s main research inter- Unraveling New Therapeutic Mechanisms Underlying est is adaptation, specifically how the Targets for Ocular Albinism Photoallodynia rods and cones in the retina adapt to Dr. Guha studies genes that may be different light intensities. associated with the misrouting of retinal Dr. Matynia’s research investigates ganglion cell (RGC) axons at the brain’s the mechanisms underlying photo optic chiasm in individuals affected with allodynia, a condition in which normal X-linked ocular albinism type 1 (OA1). levels of light produce or enhance This disease is also characterized by ocular or headache pain. Using behav- hypopigmentation and presence of ioral, molecular, genetic, and cellular macromelanosomes in the RPE. How approaches, the laboratory focuses the reduced pigmentation of OA1 RPE on corneal, retinal, and central mecha- exerts its effects on the RGCs to influ- nisms from dry eye injury, achromatop- ence the misrouting of their axons at sia, and migraine, respectively. the optic chiasm remains unsolved, and Dr. Guha’s findings have the potential to unravel new therapeutic targets for OA1.

60 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Professional Clinical Series

Alejandra Young, PhD Melissa W. Chun, OD Assistant Project Scientist Associate Clinical Professor of Ophthalmology Ocular Albinism Director of the UCLA Dr. Young’s research is focused on the Vision Rehabilitation Center study of the molecular mechanisms that Vision Rehabilitation cause ocular albinism type 1 (OA1), a disease caused by mutations in the OA1 Dr. Chun’s clinical research interests gene and characterized by hypopig- are in vision rehabilitation outcomes mentation of the retinal pigment epithe- and training techniques that maximize lium and abnormal crossing of the optic visual function. She is a member of the axons at the optic chiasm. In addition, Low Vision Research Network, a nation- she investigates the potential therapeu- wide collaboration of low vision spe- tic use of engineered human embryonic cialists for multicenter clinical studies. stem cell-derived extracellular vesicles She is also involved in visual outcome Uday Devgan, MD, FACS, for the treatment of ocular albinism. measures for various clinical studies on FRCS macular degeneration. Clinical Professor of Ophthalmology Chief of Ophthalmology, Olive View-UCLA Medical Center Dr. Devgan is a cataract and refractive surgery specialist who has taught ophthalmic surgery in more than 50 countries. He has been actively involved in resident teaching for more than two decades, and he has mentored more than 180 residents over the course of thousands of ocular surgeries, including advising former residents after the culmination of their training. Passionate about teaching the next generation of ophthalmologists, Dr. Devgan publishes the cataract surgery teaching website CataractCoach.com, and he has been honored with the ophthalmology Fac- ulty Teaching Award an unprecedented four times.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 61 ACADEMIC PERSONNEL

Rachel Feit-Leichman, MD Mitra Nejad, MD Meryl L. Shapiro-Tuchin, MD Associate Physician Diplomate Associate Physician Diplomate Associate Physician Diplomate Cataract Surgery Clinical Instructor of Ophthalmology Assistant Clinical Professor of Ophthalmology Cataract and Refractive Surgery Dr. Feit-Leichman divides her time Co-Director of the Ophthalmology between supervising residents and Dr. Nejad practices comprehensive Inpatient Consultation Service providing patient care at the Stein ophthalmology with a focus on cataract Comprehensive Ophthalmology Eye Institute’s Urgent Care Clinic, and surgery and laser refractive surgery in teaching cataract surgery and over- the Stein Eye Institute’s Cataract and Dr. Shapiro-Tuchin provides clinical seeing residents at the ophthalmol- Refractive Surgery Division. Dr. Nejad supervision to resident physicians. She ogy clinic of the Harbor-UCLA Medical is an instructor and research mentor for functions as co-director of the Oph- Center. Dr. Feit-Leichman is also active UCLA medical students and supervises thalmology Inpatient Consultation Ser- in striving to improve patient access to the UCLA residents in both cataract vice, assisting resident physicians in eye care in the greater Los Angeles and laser refractive surgery. She is also their evaluation of inpatients admitted County Healthcare System. a volunteer surgical instructor for res- to the Ronald Reagan UCLA Medical ident cataract surgery at Harbor-UCLA Center and the UCLA Medical Center, Santa Monica. Batool Jafri, MD Medical Center. Associate Physician Diplomate Assistant Clinical Professor Tania Onclinx, MD Ronald J. Smith, MD of Ophthalmology Associate Physician Diplomate Associate Physician Diplomate Cornea/External Disease/ Clinical Instructor of Ophthalmology Associate Clinical Professor of Ophthalmology Refractive Surgery Urgent Care and Objective Assessment of Surgical Dr. Jafri provides patient care as well Clinical Supervision Technique and Training as supervision to resident physicians Dr. Onclinx attends at the Urgent Care and cornea fellows. Her focus is med- Dr. Smith’s research interest is the Walk-In service at the Stein Eye Insti- ical and surgical treatment of diseases objective assessment of surgical tech- tute, and she teaches resident phy- of the cornea, external disease, and nique and development of evidence- sicians and medical students at the refractive conditions like near and far based surgical training for residents Stein Eye Institute during their subspe- sightedness. Dr. Jafri provides gen- to improve patient care. In addition cialty clinical rotation. She also provides eral ophthalmic care and offers cata- to teaching residents at the Veterans clinical supervision to resident physi- ract surgery with premium intraocular Affairs Greater Los Angeles Healthcare cians at Ronald Reagan UCLA Medi- lens implants at the Stein Eye Center– System and in the UCLA Microsurgery cal Center and UCLA Medical Center, Santa Monica. Laboratory, Dr. Smith provides cornea Santa Monica. and comprehensive eye care to patients at the Stein Eye Center–Santa Monica. Phillip Le, MD, PhD Susan S. Ransome, MD Associate Physician Diplomate Associate Physician Diplomate Laura A. Syniuta, MD Retinal and Macular Diseases Clinical Instructor of Ophthalmology Associate Physician Diplomate Dr. Le is a comprehensive ophthalmolo- HIV and Diabetic Retinopathy Pediatric Ophthalmology gist who specializes in retinal and mac- and Strabismus ular diseases. He sees patients at the Dr. Ransome is participating in a clinical Doheny Eye Center UCLA–Pasadena. research study involving HIV-infected Dr. Syniuta completed her fellowship patients who have diabetes to see training in pediatric ophthalmology and whether there is increased risk of devel- strabismus at the Stein Eye Institute in opment or progression of diabetic reti- 1999. With children’s eye and learn- nopathy when subjects are treated for ing disorders being her passion, she abdominal lipodystrophy with Egrifta sees patients at the Stein Eye Center– (tesamorelin). Santa Monica and has staffed the UCLA Mobile Eye Clinic since 2011.

62 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Federico G. Velez, MD Associate Physician Diplomate Strabismus and Childhood Eye Disorders Dr. Velez’s primary research interest is studying the mechanisms of congenital and acquired forms of strabismus. He has participated in the development of guidelines for preoperative assessment and surgical approaches to patients with convergent (esotropia), divergent (exotropia), and vertical forms of strabismus, and has developed new techniques to treat pediatric patients with eyelid abnormalities and cataracts.

Victoria Yom, MD Associate Physician Diplomate Cornea and External Diseases Dr. Yom provides comprehensive ophthalmic care and is a subspecialist in cornea/external disease. Her areas of interest include: dry eye, blepharitis, conjunctivitis, uveitis, as well as cataract surgery with advanced intraocular lenses and corneal transplantation. Dr. Yom provides clinical care at the UCLA Stein Eye Institute in Westwood and the Doheny Eye Center UCLA locations in Arcadia and Pasadena.

LECTURER Kathleen L. Boldy, VMD Lecturer in Ophthalmology

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 63 UCLA DEPARTMENT OF OPHTHALMOLOGY VOLUNTEER FACULTY

Volunteer Faculty ASSOCIATE CLINICAL PROFESSORS ASSISTANT CLINICAL PROFESSORS OF OPHTHALMOLOGY OF OPHTHALMOLOGY Gerrald Barron, MD (Senior Status) David H. Aizuss, MD CLINICAL PROFESSORS Arnold Barton, MD (Senior Status) Malvin B. Anders, MD OF OPHTHALMOLOGY Kevin J. Belville, MD Richard K. Apt, MD J. Bronwyn Bateman, MD Louis Bernstein, MD (Senior Status) Reginald G. Ariyasu, MD, PhD Bruce B. Becker, MD, PC W. Benton Boone, MD Arthur A. Astorino, MD Michael S. Berlin, MD Harvey Brown, MD Mark A. Baskin, MD William P. Chen, MD Andrew E. Choy, MD Arthur Benjamin, MD Michael Colvard, MD Melissa W. Chun, OD Katherine L. Bergwerk, MD Paul Deiter, MD (Senior Status) Peter J. Cornell, MD Betsy E. Blechman, MD Uday Devgan, MD, FACS, FRCS Chief of Ophthalmology Bernard Davidorf, MD (Senior Status) Cynthia A. Boxrud, MD Olive View-UCLA Medical Center Paul B. Donzis, MD Amarpreet S. Brar, MD Donald Dickerson, MD (Senior Status) Robert E. Engstrom, MD Almira W. Cann, MD, PhD Donald S. Fong, MD, MPH Kathryn M. Gardner, MD Arnett Carraby, MD Leland M. Garrison, MD Donald I. Goldstein, MD Vicki K. Chan, MD Ronald Gaster, MD Michael J. Groth, MD Andrew M. Chang, MD Thomas A. Hanscom, MD Andrew Henrick, MD Candice Chen, MD Dale Heuer, MD Edwin P. Hill, MD Thomas B-H. Choi, MD John D. Hofbauer, MD Jonathan A. Hoenig, MD Milton W. Chu, MD Kenneth J. Hoffer, MD Richard H. Hoft, MD Robert A. Clark, MD C. Richard Hulquist, MD David F. Kamin, MD Charles A. Cooper, MD Barry M. Kerman, MD Stanley Kopelow, MD (Senior Status) Hajir Dadgostar, MD Roger A. Kohn, MD Joseph Lambert, MD (Senior Status) Yadavinder P. Dang, MD Howard R. Krauss, MD Brian L. Lee, MD Jonathan M. Davidorf, MD Benjamin C. Kwan, MD Steven Leibowitz, MD John L. Davidson, MD Jeremy Levenson, MD (Senior Status) Gene Matzkin, MD (Senior Status) Sanford S. Davidson, MD Jonathan I. Macy, MD Joan E. McFarland, MD Louise Cooley Davis, MD Ezra Maguen, MD James McKinzie, MD (Senior Status) Farid Eghbali, OD Robert K. Maloney, MD Alan Norton, MD (Senior Status) Troy R. Elander, MD Samuel Masket, MD John F. Paschal, MD (Senior Status) Naomi L. Ellenhorn, MD Leon G. Partamian, MD Firas Rahhal, MD Calvin T. Eng, MD George Primbs, MD (Senior Status) Michael Reynard, MD Doreen T. Fazio, MD Yaron S. Rabinowitz, MD David S. Robbin, MD Sanford G. Feldman, MD George M. Rajacich, MD David E. Savar, MD Laura E. Fox, MD Teresa O. Rosales, MD Timothy V. Scott, MD Ronald P. Gallemore, MD Robert J. Schechter, MD (Senior Status) Kayur Shah, MD George H. Garcia, MD Jerry Sebag, MD Albert Sheffer, MD Leslie C. Garland, MD (Senior Status) Alan L. Shabo, MD James D. Shuler, MD W. James Gealy, Jr., MD Norman Shorr, MD Yossi Sidikaro, MD, PhD Damien Goldberg, MD Roger W. Sorenson, MD (Senior Status) Matthew Sloan, MD Lawrence “Tim” Goodwin, MD Ronald J. Smith, MD Lawrence H. Green, MD (Senior Status) Alfred Solish, MD, MS Richard Havunjian, MD Kenneth D. Steinsapir, MD Man M. Singh Hayreh, MD Sadiqa Stelzner, MD, MA, FACS Matthew L. Hecht, MD William C. Stivelman, MD (Senior Status) David A. Hollander, MD Hector L. Sulit, MD Jeffrey Hong, MD Kamal A. Zakka, MD Catherine J. Hwang, MD, MPH

64 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Morton P. Israel, MD Meryl Shapiro-Tuchin, MD CLINICAL INSTRUCTORS Steven J. Jacobson, MD David M. Shultz, MD IN OPHTHALMOLOGY Batool Jafri, MD Eliot B. Siegel, MD Michael L. Baker, OD Aarchan Joshi, MD Lance M. Siegel, MD Eduardo Besser, MD Véronique H. Jotterand, MD John D. Slaney, MD Maria Braun, MD Jason Jun, MD Robert J. Smyth, MD Stephen S. Bylsma, MD Ganesha Kandavel, MD Kenneth O. Sparks, MD Andrew Caster, MD J. David Karlin, MD Mehryar “Ray” Taban, MD, FACS John J. Darin, MD (Senior Status) David S. Katzin, MD Homayoun Tabandeh, MD Paul J. Dougherty, MD James F. Kleckner, MD (Senior Status) Robert C. Tarter, MD Sean Dumars, MD Jerome R. Klein, MD Debra G. Tennen, MD Daniel Ebroon, MD Craig H. Kliger, MD Teddy Y. Tong, MD Brad S. Elkins, MD Howard E. Lazerson, MD (Senior Status) Sterling M. Trenberth, MD Nicole Fram, MD Robert T. Lin, MD (Senior Status) Benjamin Graham, OD Joanne E. Low, MD Robert C. Tudor, MD (Senior Status) Pamela Golchet, MD Bryant J. Lum, MD Henry E. Ullman, MD Satvinder Gujral, MD Michael C. Lynch, MD Tay J. Weinman, MD (Senior Status) Lawrence M. Hopp, MD, MS M. Polly McKinstry, MD Irwin S. Weiss, MD (Senior Status) Anisha J. Judge, MD Ashish M. Mehta, MD Sidney J. Weiss, MD Ganesha Kandavel, MD Kenneth J. Miller, MD (Senior Status) Jon D. Wender, MD Michael Kapamajian, MD David R. Milstein, MD Scott Whitcup, MD Douglas Katsev, MD Ronald L. Morton, MD David L. Williams, MD (Senior Status) Rajesh Khanna, MD Roger L. Novack, MD, PhD Jeffrey V. Winston, MD Julie A. King, MD David Paikal, MD David M. Winters, MD (Senior Status) Mark H. Kramar, MD Alpa A.S. Patel, MD David L. Wirta, MD Daniel Krivoy, MD James H. Peace, MD Barry J. Wolstan, MD Mark Landig, OD Gilbert Perlman, MD (Senior Status) Wilson C. Wu, MD, PhD Amir Marvasti, MD Cheryl J. Powell, MD Michael C. Yang, MD Laurie C. McCall, MD John R. Privett, MD (Senior Status) Patrick C. Yeh, MD Mitra Nejad, MD Laurence N. Roer, MD Richard H. Yook, MD (Senior Status) Jayantkumar Patel, MD Gerald Sanders, MD (Senior Status) Andrew Young, MD Susan S. Ransome, MD Aaron M. Savar, MD Peter D. Zeegen, MD (Senior Status) Steven H. Rauchman, MD Barry S. Seibel, MD Richard H. Roe, MD Christian Sanfilippo, MD Louis M. Savar, MD Vivian Shibayama, OD Mark Silverberg, MD Abraham Soroudi, MD Sharon N. Spooner-Dailey, MD Laura A. Syniuta, MD Rosalind Vo, MD Mark Volpicelli, MD Ye Elaine Wang, MD Mathew Wang, MD Peter H. Win, MD

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 65 CONSULTING MEMBERS OF STEIN EYE INSTITUTE EMERITUS FACULTY THE STEIN EYE INSTITUTE

Robert W. Baloh, MD Dean Bok, PhD Professor of Neurology and Surgery (Head and Neck) Dolly Green Chair of Ophthalmology Professor of Ophthalmology Emeritus Ferdinand V. Coroniti, PhD Distinguished Research Professor Professor, Department of Physics of Neurobiology and Astronomy Member of the Brain Research Institute David Eisenberg, DPhil Investigator, Howard Hughes Medical Institute Richard Casey, MD Paul D. Boyer Professor of Biochemistry Health Sciences Clinical Professor and Molecular Biology Emeritus Professor, Departments of Chemistry and Biochemistry, and Biological Chemistry Gordon L. Fain, PhD Molecular Biology Institute Distinguished Professor of the Departments of Integrative Biology/ Alan M. Fogelman, MD Physiology Emeritus Bradley R. Straatsma, MD, Castera Professor and Executive Chair JD Department of Medicine Professor of Ophthalmology (Active Recall) Professor of Ophthalmology Emeritus Alan D. Grinnell, PhD Founding Chair, Department Professor of Physiology and of Ophthalmology Physiological Science Michael O. Hall, PhD Founding Director, Stein Eye Institute Director, Jerry Lewis Neuromuscular Professor of Ophthalmology Emeritus Research Center Founding Member of the Director, Ahmanson Laboratory of Stein Eye Institute Neurobiology Barry A. Weissman, OD, PhD C. Kumar Patel, PhD Robert S. Hepler, MD Professor of Ophthalmology Emeritus Professor, Department of Physics Professor of Ophthalmology Emeritus and Astronomy Founding Chief, Neuro-Ophthalmology Marc O. Yoshizumi, MD Leonard H. Rome, PhD Division Senior Associate Dean for Research Professor of Ophthalmology Emeritus Professor of Biological Chemistry Joseph Horwitz, PhD Peter C. Whybrow, MD Distinguished Professor of Judson Braun Professor and Ophthalmology Emeritus (Active Recall) Executive Chair Department of Psychiatry and Biobehavioral Sciences Sherwin D. Isenberg, MD Director and Physician in Chief Professor of Ophthalmology and Neuropsychiatric Institute Pediatrics Emeritus

Allan E. Kreiger, MD Professor of Ophthalmology Emeritus (Active Recall) Founding Chief, Retina Division

Ralph D. Levinson, MD Health Sciences Clinical Professor of Ophthalmology Emeritus

66 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues RESIDENTS AND FELLOWS

Residents Fellows International Fellows

THIRD-YEAR RESIDENTS Cornea/External Ocular Diseases Cornea Research 2017–2020 and Refractive Surgery Clémence Bonnet, MD Judd Cahoon, MD Kishan Gupta, MD France Tamara L. Lenis, MD, PhD (EyeSTAR) Andrew Lee, MD Seyed Reza Ghaffari Dehkharghani, MD Iran Cameron Pole, MD Arpine Barsegian, MD (Doheny Eye Centers UCLA) Duangratn Niruthisard, MD David T. Stark, MD, PhD (EyeSTAR) Thailand William Stoddard, MD Glaucoma Rutuja Unhale, MD Sandip Suresh, MD Victoria Tseng,MD, PhD India Qing Wang, MD, PhD (EyeSTAR) Peter Dentone, MD Madeline Yung, MD (Doheny Eye Centers UCLA) Comprehensive Ophthalmology/ Andrew Chen, MD Cataract SECOND-YEAR RESIDENTS None 2018–2021 Medical Retina and Glaucoma Michael DaSilva, MD Ophthalmic Genetics Agustina de Gainza, MD Eliot Dow, MD Alexander Juhn, MD Argentina Nicholas Iafe, MD Tieu Vy Nguyen, MD Qiang Fu, MD Jaffer Kattan, MD Neuro-Ophthalmology China Anh Pham, MD, PhD (EyeSTAR) None Golnoush Mahmoudi Nezhad, MD Ernest Puckett, MD Iran Austin Woolley, MD Orbital and Ophthalmic Vahid Mohammadzadeh, MD Andrea Yonge, MD Plastic Surgery Iran Liza Cohen, MD Diana Salazar Vega, MD FIRST-YEAR RESIDENTS Justin Karlin, MD Colombia 2019–2022 Yifan Song, MD Abhinav Golla, MD, MPH Pathology (Eye) China Terry Hseih, MD, PhD None Xiaobin Xie, MD Yoon Lee, MD (Doheny Eye Centers UCLA) Pediatric Ophthalmology China Justin Park, MD and Strabismus Andres Parra, MD None Medical Retina and Ravin Sajnani, MD Ophthalmic Genetics Lynn Shih, MD Uveitis and Inflammatory Jeeyun Ahn, MD Claire Smith, MD, MFA Eye Disease Korea None Giulia Corradetti, MD Italy EyeSTAR Trainees Vitreoretinal Diseases and Surgery Assaf Hilely, MD Adrian Au, MD Wei Gui, MD Israel Sarah Cheng, MD Kirk Hou, MD, PhD Neuro-Ophthalmology Erika Ellis, MD Niranjan Manoharan, MD Adam Weiner, MD Alvaro Mejia Vergara, MD Tamara L. Lenis, MD Mexico Anh H. Pham, MD, PhD Eduardo Nicolas Seleme Herrero, MD David Stark, MD, PhD Chile Michel Sun, MD, PhD Qing Wang, MD, PhD Orbital and Ophthalmic Plastic Surgery Alexandra Manta, MD EyeMBA Trainee Romania

Cory Hoeferlin, MD

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 67 RESIDENTS AND FELLOWS

Predoctoral Postdoctoral Research Fellows Research Fellows

Pediatric Ophthalmology Kevin Eden Abhishek Chadha, PhD Mohammad Aleassa, MD W. Blake Gilmore Arpita Dave, PhD Jordan Khristopher Griffis Aurelie Dos Santos, PhD Sunghyuk Moon, MD Norianne Ingram Antonio Escudero Paniagua, PhD Korea Margaux Kreitman Matthew Gerber, PhD Federica Solanes, MD Eunice Ng Boyu Gu, PhD Chile Joseph Park Roni Hazim, PhD Uveitis Katie Pohl Nan Hultgren, PhD None Gabriel Pollock Somaye Jafari, PhD Gabriela Sendek Ala Morshedian, PhD Visual Physiology Joann Roberts, PhD None Maxime Ruiz, PhD Simona Torriano, PhD Vitreoretinal Diseases and Surgery Ankita Umapathy, PhD Frederic Gunnemann, MD Tongzhou Xu, PhD Germany Chi Zhang, PhD Moritz Pettenkofer, MD Germany Wenlin Zhang, MD, PhD

68 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Research and Funding RESEARCH FOCUS

Exploring the Optic Nerve Stein/Doheny Research Group Leads the Way in Neuro-Ophthalmology Clinical Trials

research team of neuro-ophthal- Dr. Sadun is especially interested in mologists in the UCLA Department Leber’s hereditary optic neuropathy, a Aof Ophthalmology is attracting disease that affects only the genes of considerable interest from pharmaceuti- the mitochondria and can cause sudden cal companies for the group’s expertise and permanent blindness, usually among in optic nerve diseases. Although the individuals in their teens or 20s. The diseases studied by Alfredo A. Sadun, genetics for Leber’s are simple—when MD, PhD, and his colleagues are rare, the mother has a genetic defect in her they are increasingly viewed as models mitochondria, it will always be passed for both ophthalmologic and non-oph- down to her children; Leber’s cannot be thalmologic conditions that affect much passed by the father. “The genetic defect larger populations, but are more complex is necessary but not sufficient for blind- and difficult to study. ness,” Dr. Sadun notes. “Something else Dr. Sadun, Flora L. Thornton Endowed triggers the disease and makes carriers Chair in Vision Research at Doheny and go blind, suddenly and dramatically.” vice chair of ophthalmology, Doheny Eye Leber’s hereditary optic neuropathy is Center UCLA, is part of six formal clinical extremely rare—so rare, in fact, that Dr. trials in neuro-ophthalmology, making Sadun sees many of the patients from the UCLA Department of Ophthalmology throughout the United States who are group by far the most active neuro-oph- suspected of having the disease. But thalmology research group in the country. the central involvement of mitochondria Neuro-ophthalmology is a subspecialty in the disease also makes it of consider- focusing on how the brain works with the able interest as it becomes increasingly eye and processes visual information, as apparent that mitochondria are import- well as how the eye sends messages to ant in other, more common conditions. the brain. From the beginning of his career, These include vision diseases such as Medical visualization showing an overhead view of the human head. The optic nerve, Dr. Sadun has been a leader in the lat- macular degeneration and glaucoma, which connects the eyes to the brain, is ter, also known as the afferent pathway. as well as neurological diseases such as highlighted in blue. In particular, Dr. Sadun and his col- Alzheimer’s and Parkinson’s. With three leagues have concentrated on the optic decades of experience determining the nerve—the cable connecting the eye and natural history of a pure mitochondrial the brain, composed of 1.2 million fibers, disease, Dr. Sadun’s group has emerged each representing a different pixel point as a focal point for clinical trials of optic on the brain’s vision map. “It turns out that nerve conditions such as Leber’s that there are obvious and not-so-obvious could also prove effective in treating the diseases of the optic nerve,” Dr. Sadun more common conditions. explains. “The optic nerve can suffer any Of the six ongoing clinical trials headed disease the brain can—such as tumors, by the UCLA Department of Ophthalmol- stroke, and multiple sclerosis—but there ogy team, four involve Leber’s hereditary are also diseases that affect the optic optic neuropathy; the other two are for nerve specifically, which is what I find patients who experience a type of stroke to be the most compelling.” Intriguingly, of the optic nerve, properly termed acute these conditions almost all involve injury nonarteritic anterior ischemic optic neu- in one way or another to mitochondria— ropathy (NAION), in which a loss of blood the powerhouse of cells. “In these dis- flow to the nerve causes sudden vision eases, if the mitochondria become sick, loss in one eye. Three of the trials for the canary in the coal mine is the optic Leber’s use gene therapy—injecting a nerve,” Dr. Sadun says. virus that delivers a “good” version of

70 UCLA STEIN EYE INSTITUTE | Research and Funding the mutated gene into the inner layer of We know the starting point is 1.2 million “The optic nerve can suffer any the eye, where the cells that give birth to fibers, we know their size and location, disease the brain can—such the optic nerve reside. The fourth Leb- and any damage can be assessed accu- er’s-related study is the latest in a series rately through a variety of tests. In addi- as tumors, stroke, and multiple of trials Dr. Sadun has led using small tion, when we have a patient complaining sclerosis—but there are also molecules—in this case, in the form of a of a black spot or blurred vision, that’s diseases that affect the optic topical ophthalmic solution—designed to much more specific than when an Alz- allow the affected cells to compensate for heimer’s patient complains of not being nerve specifically, which is the genetic error. able to think right.” what I find to be the most As recently as 15 years ago, there were Using the optic nerve as a model compelling.” no neuro-ophthalmology clinical trials for neurological studies, results in less in the United States, Dr. Sadun notes, “noise,” which means it takes fewer ALFREDO A. SADUN, MD, PHD because of the perceived small size of the patients to prove the efficacy of a treat- market for neuro-ophthalmologic drugs. ment, Dr. Sadun notes. The hope is that Vice Chair of Ophthalmology, Doheny Eye Center UCLA That was before it became apparent that once that proof of principle is established because the optic nerve is part of the for patients with optic nerve conditions, brain, clinical trials involving diseases of the same therapy could be tested in the optic nerve could serve as testing patients with the more common neuro- grounds for more complex neurological logical diseases, using the already estab- diseases that affect far more people. lished information about dosing and side Dr. Sadun made that point early in his effects. That potential to benefit large career with a study he published in the numbers of patients is what makes the mid-1980s showing that the optic nerve neuro-ophthalmology research at the is also damaged in Alzheimer’s disease. UCLA Department of Ophthalmology of “The reason I chose that approach was such great interest to the pharmaceuti- that I figured one quick measurement of cal industry. visual function such as color vision was substantially easier than subjecting people to a few days of psychometric examinations,” Dr. Sadun explains. “We have much better ways of measuring signs and symptoms for the eye.” Ever since, he has consistently made the case that the accessibility of the optic nerve—through both vision testing and the ability to image the eye as a transpar- ent organ—renders it a powerful model for gaining insight into a host of neurological diseases. “There is much less ‘noise’ in studies of the optic nerve than there would be for something like Alzheimer’s disease, where there are so many vari- ations that could potential influence the results,” Dr. Sadun says. “Any disease of the brain also affects the optic nerve, but whereas the brain is diffuse, complicated, and hard to measure, in the optic nerve these diseases are very precise. Research Contracts and Grants

Vision-Science Research Sophie X. Deng, MD, PhD Joseph Horwitz, PhD Development of Stem Cell-Based Analysis of Lens Crystallins and Active Funding Therapies for Limbal Stem Cell Cataractous Mutants at Deficiency High Hydrostatic Pressure ADMINISTERED BY THE National Eye Institute National Eye Institute STEIN EYE INSTITUTE Duration: 2/1/19–1/31/24 Duration: 4/1/14–3/31/20 $250,000 $150,000 Faculty Development of Small-Molecule Alex A. Huang, MD, PhD Wnt Mimetics for Corneal Epithelial Discovery and Characterization of Suraj P. Bhat, PhD Cell Regeneration Anterior Sclera Pathology in Glaucoma Childhood Cataractogenesis: National Eye Institute National Eye Institute Heterogeneity of Gene Expression (Multi-PI with Jie J. Zheng, PhD) Duration: 9/30/14–9/29/19 National Eye Institute Duration: 9/30/18–8/31/22 $203,981 Duration: 1/1/15–12/31/19 $318,703 $329,180 Research to Prevent Blindness Gordon L. Fain, PhD Career Development Award Ava K. Bittner, OD, PhD Physiology of Photoreceptors Research to Prevent Blindness, Inc. CARE Study: Community Access National Eye Institute Duration: 1/1/16–6/30/20 Through Remote Eyesight Duration: 8/1/17–7/31/21 $75,000 Administration for Community Living $250,000 Sub-award from Wayne L. Hubbell, PhD Visual Integration in the Retina of the New England College of Optometry Molecular Basis of Membrane Excitation Sea Lamprey Petromyzon Marinus Duration: 9/30/19–9/29/22 National Eye Institute Great Lakes Fishery Commission $75,764 Duration: 5/1/15–4/30/20 Duration: 1/1/19–12/31/21 $313,480 Joseph Caprioli, MD $73,562 Clinical Research Program in Glaucoma Jean-Pierre Hubschman, MD Debora B. Farber, PhD, DPhhc Simms-Mann Family Foundation Vitreoretinal Surgery via Robotic Patient-Derived iPSCs, CRISPR/Cas Duration: 7/1/14–6/30/20 Microsurgical System with Image and RPE-Derived Exosomes for the $50,000 Guidance, Force Feedback, Virtual Treatment of Ocular Albinism Fixture, and Augmented Reality Vision of Children Anne L. Coleman, MD, PhD National Eye Institute Duration: 6/1/16–12/31/20 2019 Grant Application to the Duration: 2/1/19–1/31/24 $163,783 Nicholas Endowment for the $286,083 UCLA Mobile Eye Clinic (UMEC) The Nicholas Endowment Gary N. Holland, MD Intraocular Robotic Interventional and Duration: 12/5/19–12/31/20 Systemic Immunosuppressive Therapy Surgical System for Automated $75,000 for Eye Diseases Cataract Surgery Cohort Study (SITE) National Eye Institute Joseph L. Demer, MD, PhD University of Pittsburgh Duration: 9/30/19–8/31/23 Biomechanical Analysis in Duration: 3/2/16–3/2/21 $393,944 Non-monetary Contract Strabismus Surgery A Natural History of Macular National Eye Institute Systemic Immunosuppressive Therapy (Parafoveal) Telangiectasia Duration: 5/1/20–4/30/24 for Eye Disease Lowy Medical Research Institute $405,075 (Cancer Surveillance and Research Duration: 9/1/05–12/31/21 Data-Driven Biomechanical Simulation Branch/CCR) $72,650 of Eye Movement and Strabismus University of Pittsburgh National Eye Institute Duration: 3/2/16–3/2/21 Michael Ip, MD Sub-award from Non-monetary Contract The SCORE 2 Long-Term Follow-Up (SCORE2 LTF) George Mason University Measuring Vision-Related Function and National Eye Institute Duration: 6/1/19–5/30/23 Quality of Life in Children with Uveitis Sub-award from $100,575 Children’s Hospital and Regional Pennsylvania State University Medical Center Duration: 4/1/19–3/31/21 Duration: 5/15/18–5/14/20 $29,579 $2,778

72 UCLA STEIN EYE INSTITUTE | Research and Funding Bartly J. Mondino, MD Vision Science Training Program Gene Editing of the Usher 1B Gene RPB Unrestricted Grant National Eye Institute Foundation Fighting Blindness Research to Prevent Blindness, Inc. Duration: 9/1/17–8/31/22 Duration: 6/1/17–5/31/20 Duration: 1/1/12–12/31/20 $238,263 $100,000 $115,000 Molecular Mechanisms of Cellular Mechanisms of Disease in Photoreceptor Adaptation Patient-Specific RPE Cells Kouros Nouri-Mahdavi, MD National Eye Institute Foundation Fighting Blindness Detection of Disease Progression in Duration: 2/1/19–1/31/24 Sub-award from Advanced Glaucoma $267,551 University of California, San Francisco National Eye Institute Duration: 6/1/17–5/31/20 Duration: 3/1/20–2/28/25 David Sarraf, MD $164,930 $261,500 In Vivo Ultrastructure of RPE Cell Biology, Aging, and Disease Chorioretinal Disease Stacy L. Pineles, MD National Eye Institute National Eye Institute Physical Injuries in Patients with Duration: 9/1/17–5/31/22 Sub-award from Doheny Eye Institute Pediatric Eye Diseases $296,846 $16,515 National Eye Institute Duration: 1/1/19–12/31/20 Test of Readthrough Drug Treatment for Gabriel H. Travis, MD $125,000 UGA PTC in the Usher 1B Gene Instrumentation Grant for Stein Eye Foundation Fighting Blindness RPB Walt and Lilly Disney Award for Investigators Duration: 1/1/19–12/31/21 Amblyopia Research Bruce Ford and Anne Smith Bundy $180,615 Research to Prevent Blindness, Inc. Foundation Duration: 7/1/14–12/31/19 Duration: 8/16/11–8/15/20 Exploring the Relationship of $100,000 $100,000 Water Flow Across the RPE and Mutant-MYO7A/Usher 1B Mechanisms for Light-Driven Roxana Radu, MD National Eye Institute Chromophore Synthesis by The Role of Complement in Recessive Duration: 1/1/20–12/31/21 Müller Cells to Regenerate Cone Opsin Stargardt Disease $150,000 and Maintain Cone Sensitivity National Eye Institute National Eye Institute Understanding Mitochondrial Defects in Duration: 8/1/15–7/31/21 Duration: 1/1/20–12/31/24 Choroideremia RPE $250,000 $276,107 Choroideremia Research Foundation Identification of Bisretinoid Levels in Duration: 2/1/20–1/31/21 ABca4-/- Mouse Retinas Irena Tsui, MD $61,079 NightstaRx Retinal and Choroidal Vasculature Duration: 9/26/18–9/25/19 Changes in Healthy and Xian-Jie Yang, PhD $25,641 High-Risk Pregnancies Neuroprotection Mechanism for National Eye Institute Photoreceptors Analysis of Bisretinoids in the Duration: 2/1/20–1/31/22 National Eye Institute Abca4-/- Mouse Eyes $165,063 Duration: 5/1/16–4/30/21 Biogen Research Corporation $366,660 Duration: 2/25/20–8/25/20 David S. Williams, PhD $32,525 The Photoreceptor Cilium Jie Zheng, PhD National Eye Institute Development of Small-Molecule Alapakkam P. Sampath, PhD Duration: 5/1/13–4/30/20 Wnt Mimetics for Corneal Epithelial Molecular Basis of Photoreceptor Wiring $250,000 Cell Regeneration National Eye Institute National Eye Institute (Multi-PI with (Multi-PI award with Scripps Clinic and Photoreceptor Disk Membrane Sophie Deng, MD, PhD) Research Foundation) Morphogenesis Duration: 9/30/18–8/31/22 Duration: 5/1/17–4/30/22 National Eye Institute $318,703 $90,760 Sub-award from University of California, Santa Barbara Analyses of Retinal Circuits After Duration: 4/1/15–3/31/20 Rod Rescue in a Mouse Model of $124,797 Human Blindness National Eye Institute Stein Eye Institute Core Grant for (Multi-PI award with University of Vision Research Southern California) National Eye Institute Duration: 9/1/16–8/31/21 Duration: 9/1/15–6/30/20 $95,673 $500,000

Research and Funding | UCLA STEIN EYE INSTITUTE 73 Professional Research Series Vision-Science Research Functionally Validated Structural Endpoints for Early AMD Doug Chung, PhD Active Funding University of Alabama at Birmingham Elucidating the Role of SLC4A11 in Sub-award on NEI Grant EY029595 Congenital Hereditary Endothelial ADMINISTERED BY THE Duration: 5/1/19–2/29/24 Dystrophy DOHENY EYE INSTITUTE $125,203 Knights Templar Eye Foundation, Inc. Discovery and Validation of AMD Duration: 7/1/19–12/31/20 Steven Barnes, PhD Biomarkers for Progression Using $65,000 Functional Resilience of Retinal Ganglion Cells During Mitochondrial Deep Learning National Eye Institute Sonia Guha, PhD Dysfunction Duration: 8/1/19–7/31/21 Role of Doublecortin in Axonal Glaucoma Research Foundation $150,000 Misrouting in OA1 -/- Mice Shaffer Grant Vision of Children Duration: 3/1/19–2/29/20 Artificial Intelligence for Assessment of Duration: 7/1/14–11/12/20 $50,000 Stargardt Macular Atrophy $159,848 National Eye Institute Alex A. Huang, MD, PhD Duration: 1/1/20–12/31/21 Anna Matynia, PhD Glaukos Research (Outflowing Imaging) $150,000 Targeted Hsp70 as a Therapeutic for Glaukos Corporation Automated End-to-End Retinal Central Retinal Artery Occlusion Duration: 10/27/15–11/30/19 Screening System with Robotic Image Rubicon Biotechnology $10,000/two years Capture and Deep Learning Duration: 9/30/17–9/30/19 Dynamic Variable Aqueous Humor Eyenuk, Inc. $40,400 Outflow and Glaucoma Therapies Sub-award on NEI Grant EY029652 Molecular, Cellular, Anatomical, in the Human Eye Duration: 9/30/19–9/29/20 and Neurobiological Investigation National Eye Institute $9,554 of Melanopsin-Expressing Corneal Duration: 5/1/20–4/30/25 Innervation, and Its Role in Pain $341,397 Alfredo A. Sadun, MD, PhD and Photophobia Investigating Subconjunctival Post-mortem Analysis of LHON Patient National Eye Institute Lymphatics for the Treatment of Who Had Received AAV‑2 w/ ND4 Duration: 2/1/20–12/31/24 Glaucoma and Eye Disorders Intravitreal Injection in One Eye $250,000 Glaucoma Research Foundation GenSight Duration: 7/20/18–10/31/19 Microglia Function in Pathogenesis of Shaffer Grant $12,739 Retinal Hemangioblastomas Associated Duration: 2/1/20–1/31/21 with Von Hippel-Lindau Disease $50,000 Deming Sun, MD VHL Alliance Role of IL-17+ Autoreactive T Cells in Duration: 11/15/19–11/14/22 Ram Kannan, PhD Experimental Autoimmune Uveitis (EAU) $50,000 Novel Mechanism of Subretinal Fibrosis in Age-Related Macular Degeneration National Eye Institute Duration: 1/1/20–12/31/23 Alejandra Young, PhD National Eye Institute $300,608 Identification of the OA1 Molecule Duration: 5/1/20–4/30/24 Partners Critical for Axonal Guidance of $304,708 Determination of the Role of Adenosine RGCs Growth Cones Deaminase on Two Major Pathogenic (Proposal Continuation of SriniVas R. Sadda, MD (IFN-y+ and IL-17+) T Cells Responses Grant #20142326) Advanced Image Analysis Tools for Leadiant Biosciences Vision of Children Diabetic Retinopathy Telemedicine Duration: 1/1/20–12/31/20 Duration: 11/1/13–11/30/20 Application $51,400 $215,566 Eyenuk, Inc. Sub-award on NEI Grant SB1EY027241 James C. Tan, MD, PhD Duration: 9/30/16–7/31/19 Fibrillin-1 and TGFB2 Abnormality $19,108 Models PAOG Automated Image-based Pathogenesis and Treatment Biomarker Computation Tools for National Eye Institute Diabetic Retinopathy Duration: 9/30/17–11/30/19 Eyenuk, Inc. $250,000 Sub-award on NEI Grant TR000377 Contractile Modulation of Distal Duration: 7/1/18–6/30/20 Aqueous Humor Drainage $84,010 National Eye Institute Duration: 6/1/18–11/30/19 $125,000

74 UCLA STEIN EYE INSTITUTE | Research and Funding Yuhua Zhang, PhD Joseph Caprioli, MD Gary N. Holland, MD In Vivo Ultrastructure of Protocol INN-005 META-MUST Chorioretinal Disease InnFocus, Inc National Eye Institute National Eye Institute Duration: 2/4/16–11/13/19 Sub-award from Duration: 1/1/19–12/31/20 $435,556 Johns Hopkins University $239,899 Duration: 9/30/14–1/31/21 INN-005-EXT $39,180 InnFocus, Inc Clinical Research Duration: 4/29/20–4/28/25 ZEDS $63,388 New York University Active Funding Duration: 4/3/17–7/31/21 Sophie X. Deng, MD, PhD $345,545 ADMINISTERED BY UCLA Safety and Feasibility of Cultivated ADalimumab Vs. Conventional Autologous Limbal Stem Cells for ImmunoSupprEssion for Uveitis Anthony J. Aldave, MD Limbal Stem Cell Deficiency (ADVISE) Trial Vision Restoration with a California Institute for Regenerative National Eye Institute Collagen Crosslinked Boston Medicine (CIRM) Sub-award from Keratoprosthesis Unit Duration: 12/1/19–11/20/23 Johns Hopkins University Department of Defense $1,400,000 Duration: 9/30/18–8/31/23 Sub-award from K-321-201 $23,785 Massachusetts Eye and Ear Infirmary Kowa Research Institute, Inc. Duration: 9/1/15–8/31/20 Predicting Uveitis Onset in Children with Duration: 6/17/20–6/17/24 $81,011 Juvenile Idiopathic Arthritis $1,341,428 National Eye Institute Genetic Factors in Keratoconus Sub-award from Cedars-Sinai Medical Center; Brian A. Francis, MD, MS Cincinnati Children’s Hospital funded by National Eye Institute MED-MA-EYE-0635 Duration: 9/20/19–6/30/20 Duration: 12/1/14–2/28/19 Allergan Sales, LLC $98,280 $10,800 Duration: 4/1/20–12/31/20 $37,350 Jean-Pierre Hubschman, MD Benjamin B. Bert, MD Extension Study of NT-501 Ciliary Treatment of Ocular Discomfort in Simon Fung, MD Neurotrophic Factor (CNTF) Implant for Glaucoma Patients Using Multiple Structural and Functional Changes of Macular Telangiectasia (MacTel) Topical Medications Corneal Innervation After Treatment Lowy Medical Research Institute Novartis Pharmaceuticals with Cenegermin Duration: 8/14/17–6/30/22 Duration: 3/31/20–12/31/21 Dompé S.p.A. $53,145 $83,553 Duration: 3/12/20–1/1/25 $287,946 A Phase 3 Multicenter Randomized, Ava K. Bittner, OD, PhD Sham-Controlled Study to Determine Beacon Sensors and Telerehabilitation Michael B. Gorin, MD, PhD the Safety and Efficacy of Renexus® in to Assess and Improve Use of Devices Xolaris Macular Telangiectasia Type 2 for Visual Functioning (BeST-AID) NightstaRx Lowy Medical Research Institute National Eye Institute Duration: 9/28/17–8/31/19 Duration: 2/26/18–12/31/21 Duration: 2/1/19–1/31/21 (pending renewal) $290,150 $276,090 $135,770 Michael Ip, MD Development of a Behavioral NIGHT APL2-304 Intervention with Socially Assistive NightstaRx Apellis Pharmaceuticals Robots to Enhance Magnification Duration: 6/18/15–3/26/20 Duration: 5/9/19–5/8/23 Device Use for Reading $120,123 $420,429 National Eye Institute ALK-001 Duration: 2/1/20–1/31/22 RHINE Alkeus Pharmaceuticals $169,327 Genentech, Inc. Duration: 5/23/16–8/22/20 Duration: 3/5/19–3/5/23 Beacon Sensors and Telerehabilitation $46,070 $470,911 to Assess and Improve Use of Devices ARIS for Visual Functioning (BeST-AID) AR-1105-CS201 Greater Baltimore Medical Center; American Academy of Optometry Aerie Pharmaceuticals Inc. funded by National Eye Institute Duration: 3/1/19–2/28/21 Duration: 5/16/19–5/15/21 Duration: 5/1/19–6/1/24 $100,000 $70,607 $80,000 AR13503 STAR Aerie Pharmaceuticals Inc. NightstaRx Duration: 7/24/19–7/23/23 Duration: 6/13/18–6/13/21 $1,389,358 $96,333

Research and Funding | UCLA STEIN EYE INSTITUTE 75 GR40550 Detection of Disease Progression in Reality LHON Registry Genentech Foundation Advanced Glaucoma GenSight Biologics Duration: 1/17/20–1/16/24 National Eye Institute Duration: 1/16/18–10/31/20 $1,427,007 Duration: 3/1/20–2/28/21 $45,810 $401,500 OPT1039 Clinical Evaluation of the GS-LHON-CLIN-06 P200xe Indy Stacy L. Pineles, MD GenSight Biologics Optos PLC Duration: 1/3/18–1/3/21 Integrating Perceptual Learning Duration: 4/17/20–4/16/24 $474,754 Approaches into Effective Therapies for $238,060 Low Vision GS-LHON-CLIN-05 National Eye Institute John A. Irvine GenSight Biologics Sub-award from Duration: 8/23/18–8/23/21 CAM-101-01 University of California Riverside $214,091 Cambium Medical Technologies, LLC Duration: 9/1/13–7/31/19 Duration: 7/10/19–7/9/23 $166,874 David Sarraf, MD $74,572 The IAI-OCTA Study Pediatric Eye Disease Investigator Regeneron Pharmaceuticals, Inc. Rustum Karanjia, MD, PhD Group (PEDIG) Duration: 3/28/17–5/26/21 Photopic Negative Response (PhNR) Jaeb Center for Health Research $211,609 as an Objective Outcome Measure in Duration: 1/1/19–12/31/23 Mitochondrial Disease $28,499 GR40973 United Mitochondrial Disease Genentech, Inc. Luminopia VR Device Amblyopia Study Foundation Duration: 8/2/19–10/31/22 Luminopia, Inc. Duration: 12/1/17–11/20/20 $207,624 Duration: 11/28/18–11/28/21 $100,000 $52,103 In Vivo Ultrastructure of Olivia L. Lee, MD Chorioretinal Disease Peter A. Quiros, MD OCU-300 National Eye Institute QRK207 Ocugen, Inc. Sub-award from Quark Pharmaceuticals, Inc. Duration: 1/4/19–1/4/22 University of California Riverside Duration: 8/4/16–3/26/20 $342,513 Duration: 1/3/19–12/31/20 $121,227 $25,763 Colin A. McCannel, MD RGN-ON-002 Steve D. Schwartz, MD GR40548 Regenera Pharma, Ltd. MA09-hRPE-001 Genentech, Inc. Duration: 1/2/19–1/2/22 Astellas Institute for Duration: 11/15/18–11/15/21 $232,016 $455,806 Regenerative Medicine Daniel B. Rootman, MD Duration: 4/5/11–5/7/20 GR40549 $734,750 RVT-1401-2001 Genentech, Inc. Immunovant, Inc. Duration: 11/26/18–1/26/22 ACT MA09-hRPE 001(SMD) LTFU Duration: 5/14/19–5/13/23 $453,341 Astellas Institute for $292,758 Regenerative Medicine GR40550 Duration: 4/5/11–5/7/20 Genentech, Inc. SriniVas R. Sadda, MD $661,734 Duration: 1/13/20–1/12/24 BIRC-01 $1,427,007 Boston Image Reading Center 7317-CL-0003 Duration: 2/1/18–2/28/21 Astellas Institute for Regenerative ADX-2191-PVR-001 $42,520 Medicine Aldeyra Therapeutics, Inc. Duration: 8/22/18–8/22/21 Duration: 2/14/20–2/13/24 ARIS $680,530 $108,913 Greater Baltimore Medical Center; funded by National Eye Institute OPH2005 Tara A. McCannel, MD, PhD Duration: 5/1/19–6/1/24 Ophthotech Corporation AU-011-101 $80,000 Duration: 4/10/18–4/10/21 Aura Biosciences Inc. $305,751 Duration: 6/15/20–1/2/30 Alfredo A. Sadun, MD, PhD $107,566 EPI-743 Edison Pharmaceuticals, Inc. Kouros Nouri-Mahdavi, MD Duration: 10/17/14–9/24/20 High-Rate High-Resolution Chip-Scale $55,860 Ranging: A Paradigm Shift in Optical SPILH-2010 Coherence Tomography Stealth BioTherapeutics, Inc. Alcon Laboratories, Inc. Duration: 2/12/16–8/25/19 Duration: 7/1/19–6/30/21 $415,909

76 UCLA STEIN EYE INSTITUTE | Research and Funding Edmund Tsui, MD Kowa FM-700 Kowa Research Institute, Inc. Duration: 2/1/20–2/1/22 $249,600 Discovery of Quantitative Imaging Biomarkers in Pediatric Anterior Uveitis Knights Templar Eye Foundation, Inc. Duration: 7/1/20–6/30/21 $70,000

Irena Tsui, MD Retinal and Choroidal Vasculature Changes in Healthy and High-Risk Pregnancies National Eye Institute Duration: 2/1/20–1/31/21 $249,063

Research and Funding | UCLA STEIN EYE INSTITUTE 77 Clinical Research Studies

Clinical Trials Effect of Glaucoma Drainage Devices A Double-Masked Clinical Study on the Cornea in Comparison to Evaluating the Efficacy and Safety of RECRUITING IN Filtering Surgery with Antimetabolites RPh201 Treatment in Participants with FISCAL YEAR 2020 in Cases of Glaucoma Previous NAION This study aims to evaluate the endo- The primary study objective is to eval- thelial cell number in patients under uate the efficacy and safety of twice- Evaluation of Efficacy of going glaucoma drainage device weekly subcutaneous (SC) adminis- Microblepharoexfoliation Procedure implantation as part of their regular eye tration of RPh201 over 26 weeks on for Treating Anterior Blepharitis care in comparison to the endothelial visual function in participants with prior To investigate the efficacy of an FDA cell number in patients having filtering nonarteritic anterior ischemic optic approved eyelid-cleaning procedure surgery with antimetabolites or med- neuropathy (NAION). Investigators: called BlephEx™ as an adjunct to com- ical treatment. Investigators: JoAnn Peter A. Quiros, MD, and Alfredo A. mercially available eyelid cleansing A. Giaconi, MD, Joseph Caprioli, MD, Sadun, MD, PhD wipes in the treatment of eyelid debris Anne L. Coleman, MD, PhD, Simon and inflammation and to validate the K. Law, MD, PharmD, and Kouros A Phase 2b, Multicenter, Randomized, grading score of lid contamination, Nouri-Mahdavi, MD Double-blind, Placebo-controlled which is used to indicate the severity Study of RVT-1401 for the Treatment of anterior blepharitis (eyelid inflamma- Phase 3 Clinical Trial of Retinal of Patients with Active, Moderate to tion). Investigator: Saba Al-Hashimi, MD Gene Therapy for Choroideremia Severe Graves Ophthalmopathy The objective of the study is to evalu- The purpose of the study is to assess Pilot Study Comparing Three ate the efficacy and safety of a single the efficacy and safety/tolerability Delivery Methods of Mitomycin C for subretinal injection of AAV2-REP1 in of three dose regimens of RVT-1401 Trabeculectomy Surgery subjects with choroideremia. Investi in the treatment of active, moderate In this pilot explorative study, investiga- gator: Michael Gorin, MD, PhD to severe GO patients. In addition, tors are going to estimate and compare the study is designed to character- the outcomes of three different delivery A Multicenter, Open-Label, Safety, ize RVT-1401 exposure to reduction in methods of MMC for trabeculectomy: Tolerability, and Efficacy of AR-13503 anti-TSHR IgG. Investigator: Daniel B. a subconjunctival injection at the site in Subjects with Neovascular Age- Rootman, MD, MS, and Robert Alan of future trabeculectomy two to four Related Macular Degeneration (nAMD) Goldberg, MD weeks before the surgery, a subcon- and Subjects with Diabetic Macular junctival injection intraoperatively, and Edema (DME) A Phase 3 Study to Compare the topical sponge applied intraoperatively The AR-13503 SR implant is an experi- Efficacy and Safety of Intravitreal (typical use) in patients with primary mental implant that is extremely small, APL-2 Therapy with Sham Injections in open angle glaucoma who did not dissolves naturally in the body, and Patients with Geographic Atrophy (GA) have any prior filtering surgeries. Inves- contains 10.6 micrograms of the study Secondary to Age-Related Macular tigators: Joseph Caprioli, MD, Anne L. drug AR-13503. Once the AR-13503 Degeneration (AMD) Coleman, MD, PhD, JoAnn A. Giaconi, SR implant is placed in the eye, the To evaluate the efficacy of APL-2 com- MD, Simon K. Law, MD, PharmD, and study drug releases slowly, and the pared to sham injection in patients Kouros Nouri-Mahdavi, MD implant dissolves over the course of with GA secondary to AMD assessed 4 to 6 months. Investigators: Michael by change in the total area of GA Safety and Feasibility of Cultivated S. Ip, MD, SriniVas R. Sadda, MD, Gad lesions from baseline as measured by Autologous Limbal Stem Cells (LSCs) Heilweil, MD, Mohammed Khan, MD, FAF. Investigators: Michael S. Ip, MD, for Limbal Stem Cell Deficiency and Phillip Le, MD, PhD SriniVas R. Sadda, MD, Gad Heilweil, Cell therapy using cultivated autolo- MD, Mohammed Khan, MD, and Phillip gous LSCs has been developed as a Clinical Trial of Topical Fibrinogen- Le, MD, PhD potentially better alternative to various Depleted Human Platelet Lysate in direct transplantation methods of lim- Patients with Dry Eye Secondary to Arm-Mounted Heidelberg OCT-A bal tissues; it greatly lowers the risk of Graft vs. Host Disease for Noninvasive Vascular Zone damage to the donor eye by decreas- This is a Phase 1/2, randomized, Imaging in Infants with Retinopathy of ing the amount of tissues that need to double-masked, parallel-group, multi Prematurity (ROP) be harvested from the donor. Investi- center clinical trial to evaluate the This study evaluates OCT-A imaging gators: Sophie X. Deng, MD, Anthony J. safety and exploratory efficacy of two data on preterm infants who are Aldave, MD, and Vivian Shibayama, OD concentrations of Topical Fibrinogen- screened and/or treated for ROP, espe- Depleted Human Platelet Lysate cially evaluating the potentially benefi- (FD hPL) eye drop compared to con- cial effects of anti-VEGF treatment on trol eye drops in adult patients with dry foveal development and visual out- eye disease (DED) secondary to graft comes. Investigators: Alex A. Huang, vs. host disease. Investigators: John A. MD, PhD, and Irena Tsui, MD Irvine, MD, and Olivia L. Lee, MD

78 UCLA STEIN EYE INSTITUTE | Research and Funding Determining the Safety and Efficacy Macular Edema Ranibizumab vs. A Phase 3 Study of the Efficacy, Safety, of Renexus in Macular Telangiectasia Intravitreal Anti-inflammatory Therapy and Pharmacokinetics of the Port Type 2 (MERIT) Trial Delivery System with Ranibizumab in This study is assessing the safety of the The MERIT Trial was designed to deter- Patients with Neovascular Age-Related NT-501 implant in patients with macu- mine which intravitreal therapy offers Macular Degeneration (ARCHWAY) lar telangiectasia type 2. The implant, the best balance of effectiveness and The primary objective of this study a small capsule of cells that is placed tolerability in treating persistent uve- is to evaluate the non-inferiority and inside the eye, allows a controlled, itic macular edema in eyes with con- equivalence in efficacy of ranibizumab sustained release of CNTF directly to trolled uveitis but persistent macular delivered via the PDS Q24W with the the retina. Investigators: Jean-Pierre edema, specifically by comparing the 100mg/mL formulation compared with Hubschman, MD, Steven D. Schwartz, relative efficacy and safety of intra- that of 10mg/mL Q4W intravitreal ran- MD, and Hamid Hosseini, MD vitreal ranibizumab (Lucentis®) and ibizumab injections. Investigators: Colin intravitreal methotrexate to intravitreal A. McCannel, MD, Pradeep S. Prasad, Evaluating the Safety and Efficacy dexamethasone implant (Ozurdex®). MD, MBA, and David Sarraf, MD of Light-Activated AU-011 for the Investigators: Gary N. Holland, MD, Treatment of Subjects with Small to Colin A. McCannel, MD, and Pradeep A Protocol to Follow-up with Patients Medium Primary Choroidal Melanoma S. Prasad, MD on Emergency Administration of Primary objectives are to evaluate EPI-743 with Leber Hereditary the safety of intravitreal administra- Study of Luminopia One Digital Optic Neuropathy tion of one of three dose levels and Therapeutic as Amblyopia Treatment EPI-743, a form of vitamin E that has repeat dose regimens of light-activated The primary objective of this study been changed to a new compound AU-011 and one or two laser appli- is to establish the safety and efficacy in the laboratory, is an experimental cations in the treatment of subjects of the Luminopia One therapeutic for drug that may improve mitochondrial with small to medium primary choroi- the treatment of amblyopia. Investiga- function. Mitochondrial disease mani- dal melanoma. Secondary objectives tors: Joseph L. Demer, MD, PhD, Simon festations appeared to improve when include evaluating the immunogenic- Fung, MD, and Stacy L. Pineles, MD the EPI-743 was given to cells from ity and effectiveness of AU-011. Inves- a patient with Leber hereditary optic tigators: Tara A. McCannel, MD, PhD, Zoster Eye Disease Study (ZEDS) neuropathy that were grown in the lab- Colin A. McCannel, MD, and Melissa W. The purpose of this study is to find out oratory. Investigator: Alfredo A. Sadun, Chun, OD whether one year of a low dose of vala- MD, PhD cyclovir reduces complications of shin- Evaluation of a New Drug for gles affecting the eye. The study will A Trial of QPI-1007 Delivered by Single Stargardt Disease involve two groups of participants who or Multi-Dose Intravitreal Injection(s) The study purpose is to find out have eye problems due to shingles. to Subjects with Acute Nonarteritic whether a new drug for Stargardt dis- One group will receive daily valacyclo- Anterior Ischemic Optic Neuropathy ease is safe and effective. There are vir medication and the other group will (NAION) currently no proven treatments for receive a placebo. Investigators: Gary This research study tests whether the Stargardt disease, a disease that leads N. Holland, MD, Anthony J. Aldave, MD, experimental drug QPI-1007 helps to blindness in almost all cases. Investi- Sophie X. Deng, MD, PhD, and John A. prevent loss of visual acuity. QPI‑1007 gators: Michael B. Gorin, MD, PhD, and Irvine, MD is being developed to treat vision Steven Nusinowitz, PhD loss that can occur when there is not enough blood flow to the nerve tissue Evaluation of Corneal Cross-Linking Clinical Trials in the eye, such as after a stroke of the Keratoprosthesis Carrier Tissue optic nerve or from NAION. Investiga- This clinical trial evaluates the safety NOT RECRUITING IN tors: Peter A. Quiros, MD, Gad Heilweil, and efficacy of corneal collagen FISCAL YEAR 2020 MD, Michael S. Ip, MD, Mohammad cross-linking the keratoprosthesis Khan, MD, Alfredo A. Sadun, MD, PhD carrier tissue in subjects who are can- A Multicenter, Open-Label Extension didates for high-risk keratoprosthesis Study to Evaluate the Long-Term Corticosteroids for Uveitic Macular implantation because of a history of Safety and Tolerability of the Port Edema (ADVISE) corneal melts, sterile corneal ulcers, Delivery System with Ranibizumab This research study compares three or autoimmune diseases (eg, Stevens- in Patients with Neovascular treatments for macular edema in Johnson syndrome, ocular cicatricial Age-Related Macular Degeneration patients who have uveitis. Macular pemphigoid). Investigators: Anthony (PORTAL) edema is swelling of the retina at the J. Aldave, MD, and Sophie X. Deng, Continuous delivery of ranibizumab back of the eye, and it can cause vision MD, PhD from the implant, with a prolonged loss. The standard treatment is to fixed period between refills, is a novel inject corticosteroid drugs next to the approach that may result in less- eye or directly into the eye. Investiga- frequent need for retreatment than tors: Gary N. Holland, MD, and Colin A. monthly dosing and patient monitor- McCannel, MD ing. Investigators: Colin A. McCannel, MD, Pradeep S. Prasad, MD, MBA, and David Sarraf, MD

Research and Funding | UCLA STEIN EYE INSTITUTE 79 Evaluating the Efficacy of a Single Research with Retinal Cells Derived Research to Evaluate Latest Intravitreal Injection for Patients with from Stem Cells for Stargardt Improvements with Electronic Visual Leber Hereditary Optic Neuropathy Macular Dystrophy Enhancement Devices (RELIEVED) This clinical trial is to assess the effec- This study evaluates the long-term This prospective study aims to evaluate tiveness of a gene therapy in improv- safety and tolerability of MA09- patient preferences for wearable elec- ing the visual outcome in patients with hRPE cellular therapy in subjects with tronic visual aids for low vision rehabili- Leber Hereditary Optic Neuropathy advanced Stargardt macular dystro- tation and changes in visual functioning (LHON) due to a mitochondrial muta- phy from one to five years following with these devices. Investigators: Ava tion. Investigator: Alfredo A. Sadun, the surgical procedure to implant the K. Bittner, OD, PhD, Melissa Chun, OD, MD, PhD MA09-hRPE cells. Investigators: Steven and Jennie Kageyama, OD D. Schwartz, MD, Hamid Hosseini, MD, Evaluating the Use of an Implant for Jean-Pierre Hubschman, MD, Pradeep Development of a Behavioral Patients with Macular Degeneration Prasad, MD, and Irena Tsui, MD Intervention with Socially Assistive This clinical trial determines the effi- Robots to Enhance Magnification cacy, safety, and pharmacokinetics Safety and Effectiveness of the Device Use for Reading of ranibizumab delivered through CustomFlex Artificial Iris Prosthesis for The primary goals of this research are the implant using three ranibizumab- the Treatment of Iris Defects to perform the initial development and formulation arms compared with the This study is being conducted to eval- preliminary evaluation of a prototype control arm in patients with subfoveal uate the safety and effectiveness of socially assistive robot specifically for neovascular (wet) age-related macular an artificial iris prosthesis for the treat- low vision rehabilitation involving read- degeneration. The study also evalu- ment of full or partial aniridia resulting ing with magnifiers, in order to develop ates the safety of the ranibizumab port from congenital aniridia, acquired iris future protocols for larger scale clinical delivery system combination product. defects (including traumatic iris defects trials. Investigators: Ava K. Bittner, OD, Investigators: Colin A. McCannel, MD, and mydriasis), or conditions associ- PhD, Melissa Chun, OD, and Jennie Tara A. McCannel, MD, PhD, Pradeep ated with full or partial aniridia, such Kageyama, OD S. Prasad, MD, MBA, Michael B. Gorin, as ocular or oculocutaneous albinism MD, PhD, David Sarraf, MD, Michael S. and iridocorneal endothelial (ICE) syn- Low Vision Patients’ Preferences for Ip, MD, Phuc Le, MD, Gad Heilweil, MD, drome, and iris coloboma. Investiga- Illumination During Near Reading SriniVas R. Sadda, MD tors: Anthony J. Aldave, MD, and Kevin This prospective longitudinal study M. Miller, MD aims to evaluate low vision patients’ Extension Study of NT-501 Ciliary reading performance and level of diffi- Neurotrophic Factor Implant for Study for Retinopathy of Prematurity culty when using additional preferred Macular Telangiectasia This study is to determine if intravitreal lighting for near reading as provided by The primary objective of this study is ranibizumab is superior to laser abla- a commercially available desk lamp or to investigate long-term safety and tion therapy in the treatment of retinop- a bulb placed in a generic gooseneck efficacy of the NT-501 implant in par- athy of prematurity (ROP). The study desk lamp specified according to the ticipants previously enrolled in NTMT will assess the ability of these treat- patient’s preferred settings with a light- protocols. Investigators: Jean-Pierre ments to lead to regression of active ing assessment tool. Investigators: Ava Hubschman, MD, Steven D. Schwartz, ROP and prevent the development of K. Bittner, OD, PhD, Melissa Chun, OD, MD, and Hamid Hosseini, MD ocular complications that are associ- and Jennie Kageyama, OD ated with poor visual outcome. Investi- IAI-OCTA Study gator: Irena Tsui, MD AMD Ryan Initiative Study— This study is utilizing a new, FDA Longitudinal Study of Early AMD and approved, non-standard of care Reticular Pseudodrusen technology (optical coherence Clinical Studies The primary objectives of the study are tomography-angiography by Optovue) to enroll participants with early AMD to to image and evaluate the treatment Beacon Sensors and Telerehabilitation assess rate of change in drusen vol- outcomes of using standard of care The primary goal of this project is to ume and progression rates to large intravitreal Aflibercept injections for refine the methods and procedures for drusen, and associate these morpho- their approved use in patients diag- implementing innovative technologies logic changes with psychophysical nosed with neovascular age-related for low vision rehabilitation, in order to changes, including visual acuity and macular degeneration who are naive to develop future protocols for random- dark adaptation. Investigators: Michael previous Anti-VEGF therapies. Investi- ized controlled trials. Investigators: Ava B. Gorin, MD, PhD, and SriniVas R. gator: David Sarraf, MD K. Bittner, OD, PhD, Melissa Chun, OD, Sadda, MD and Jennie Kageyama, OD

80 UCLA STEIN EYE INSTITUTE | Research and Funding Anterior Imaging of Ocular Muscles Non Exudative Age-Related Imaging of Intraocular Inflammation Presbyopia is poorly understood and Macular Degeneration Imaged with The aim of this proposed research is may be due to the lens in the eye Swept Source OCT to longitudinally monitor intraocular becoming harder or the muscles that OCT imaging with SS-OCTA will be inflammation in patients with uveitis. help focus vision for reading becoming utilized to study the natural history Investigators: Edmund Tsui, MD, Simon weaker with age. The aim of this study of disease. Investigator: SriniVas R. Fung, MD, and Gary N. Holland, MD is to utilize OCT imaging technology to Sadda, MD better understand and develop thera- Study of Ocular Disease pies to combat presbyopia. Investiga- In-Vivo Ultrastructure of Using Hyper Parallel Optical tor: Alex A. Huang, MD, PhD Chorioretinal Diseases Coherence Tomography The study will utilize a novel adaptive A novel imaging technology termed OCT-A and Visual Acuity in optics (AO) imaging instrument that hyper parallel OCT (HP-OCT) will be Human Immunodeficiency Virus integrates scanning laser ophthalmos- used to evaluate patients with cata- Associated Neuroretinal Disorder copy and optical coherence tomogra- racts, corneal disease, macular dis- This study aims to characterize the phy (AO-SLO-OCT), allowing for in-vivo ease, optic nerve disease, and iris microvascular abnormalities in patients ultrastructure assessment of RPD changes that may occur from associ- with HIV via OCT-A and investigate the and individual photoreceptors in both ated ocular diseases and procedures, relationships between capillary density, en face and cross-sectional planes. as well as uveitic diseases as detected nerve fiber layer thickness, and other The study will use the AO imaging to with clinical examination or ancillary measures of visual function (visual monitor the progression of the RPD testing, such as with standard OCT. acuity, contrast sensitivity, color vision, and their impact on overlying photo Investigators: Edmund Tsui, MD, and visual fields). In addition, to compare receptors. Investigators: David Sarraf, Saba Al-Hashimi, MD the OCT-A data in HIV-positive patients MD, and Yuhua Zhang, PhD vs. controls to evaluate the hypothesis Analysis of the Corneal and that HIV-positive patients have signifi- A Clinical Trial of the Efficacy of an Limbal Epithelial Changes in Limbal cant differences in microvascular flow Investigational Drug in Patients with Stem Cell Deficiency Using In Vivo compared to normal eyes. Investiga- Geographic Atrophy (GA) Secondary Confocal Microscopy tors: Gary N. Holland, MD, and David to Age-Related Macular Degeneration Investigators are working to establish a Sarraf, MD (Gallego) system for diagnosing limbal stem cell The purpose of this study is to compare deficiency at a cellular level by correlat- Comparison of MHz OCT to the safety and efficacy of FHTR2163 ing the information from impression Standard OCT imaging versus a simulated injection on patients cytology tests, confocal microscopy This study will test a new MHz OCT with GA secondary to AMD. Investi- pictures, and medical records. Inves- system developed by engineering gators: David Sarraf, MD, Michael B. tigators: Anthony J. Aldave, MD, and collaborators and compare the per- Gorin, MD, PhD, Colin A. McCannel, Sophie X. Deng, MD, PhD formance of this new OCT system to MD, Pradeep S. Prasad, MD, MBA a standard clinical OCT device. The Biomechanical Analysis in newly designed OCT system will be A Prospective Study Examining Strabismus Surgery five to 10 times faster, leading to a Pentosan Retinal Toxicity This study aims to develop new diag- marked improvement in resolution and Patients will be evaluated for the dose nostic tests and computer models that significant reduction of artifacts. Inves- and treatment duration of Pentosan. will lead to improvements in strabismus tigator: Kouros Nouri-Mahdavi, MD The goal is to determine the risk and surgery. Tests of binocular alignment toxic profile of Pentosan, as well as the and eye movements, as well as mag- Ocular Imaging Study incidence of interstitial cystitis, in an netic resonance imaging of the extra- This study is about improving existing effort to establish clinical guidelines for ocular muscles, are being performed anterior and posterior segment imag- retinal toxicity screening. Investigator: in the Institute’s Clinical and Basic ing using optical coherence tomog- David Sarraf, MD Science Ocular Motility Laboratory raphy (OCT) instruments and/or other before and after strabismus surgery. To imaging devices. Investigators would Anterior Chamber Flare Measurements date, this research has fundamentally like to know if different imaging devices The evaluation and detection of inflam- contributed to the knowledge of the can improve the quality of images and mation is critical in management of functional anatomy of the extraocular visualization of imaged tissues. Investi- uveitis. Flare, which is one of the com- muscles and connective tissues, and gators: SriniVas R. Sadda, MD, Anthony monly assessed ocular inflammation allowed discovery of causes of com- C. Arnold, MD, Vikas Chopra, MD, Brian parameters, is the appearance of light mon strabismus and development of A. Francis, MD, MS, Gad Heilweil, MD, reflected from solutes in the anterior new types of surgeries. Investigator: Hugo Y. Hsu, MD, Alex S. Huang, MD, chamber. This study seeks to compare Joseph L. Demer, MD, PhD PhD, Michael S. Ip, MD, John A. Irvine, two platforms of laser flare photome- MD, Phillip Le, MD, Alfredo A. Sadun, try and to evaluate the reproducibility MD, PhD, David Sarraf, MD, James C. of these measurements. Investiga- Tan, MD, PhD, and Irena Tsui, MD tors: Edmund Tsui, MD and Gary N. Holland, MD

Research and Funding | UCLA STEIN EYE INSTITUTE 81 Effect of External Eyelid Weighting Natural History Study of Leber Ocular Biometric Measurements in on Lid Position in Normal and Hereditary Optic Neuropathy Angle-Closure Glaucoma Ptosis Patients Leber hereditary optic neuropathy The purpose of this study is to deter- This investigation compares the abil- (LHON) is one of the diseases where mine the potential contributing factors ity of normal and ptotic patients to the mitochondria of the retina cells are in angle-closure patients of different maintain eyelid position by adapting not functioning correctly, which can ethnicities and to determine predic- to acute and dramatic changes in pro- lead to loss of vision. This study is to tive factors for this type of glaucoma. tracting forces by using eyelid weights. obtain electroretinography (ERG) data Investigators: Joseph Caprioli, MD, This project will help elucidate the and optical coherence tomography Anne L. Coleman, MD, PhD, Simon physiology of the eyelid position main- (OCT) data from patients who carry K. Law, MD, PharmD, and Kouros tenance system, and provide insight the Leber hereditary optic neuropathy Nouri-Mahdavi, MD into its ability to respond to changes gene. Investigator: Alfredo A. Sadun, in disease. Investigator: Daniel B. MD, PhD Oculoplastic Registry Rootman, MD, MS Many orbital and ophthalmic plastic Natural History Study of surgical diseases are not well studied Eye Health Imaging Study Macular Telangiectasia in the medical literature. The purpose The purpose of this study is to expand The primary study objective is to of this study is to contribute to a large the normative database for the develop a registry of participants with database of electronic measurements Heidelberg Spectralis OCT by collect- MacTel Type 2 (as confirmed by the from medical records that allow us to ing ophthalmic data from healthy eyes Reading Center) who may agree to be study diseases in a way that was diffi- of people of Hispanic/Latino, Asian, contacted for inclusion in future clin- cult or impossible before. Investigators: and African American descent. Investi- ical trials. Investigators: Jean-Pierre Robert Alan Goldberg, MD, and Daniel gators: Kouros Nouri-Mahdavi, MD, and Hubschman, MD, Hamid Hosseini, MD, B. Rootman, MD, MS Joseph Caprioli, MD Allan E. Kreiger, MD, Tara A. McCannel, MD, PhD, Pradeep S. Prasad, MD, Optic Nerve in Amblyopia Genetic and Anatomic Studies of MBA, Irena Tsui, MD, and Steven D. Amblyopia is a major cause of child- Eye Movement Disorders Schwartz, MD hood visual loss. This study uses high This study is conducting magnetic resolution, surface-coil magnetic res- resonance imaging of the extraocu- Noninvasive Methods for Early onance imaging to study optic nerve lar muscles. This procedure clarifies Detection of Alzheimer Disease size in amblyopia. It tests the theory the phenotypes and mechanisms of The purpose of this study is to obtain that the optic nerve is smaller than congenital cranial dysinnervation syn- electroretinography data and opti- normal in amblyopia and that optic dromes whose hereditary properties cal coherence tomography data from nerve size may be a limiting factor in have been characterized using modern patients with Alzheimer disease, with restoration of vision by amblyopia treat- molecular genetics. Patients with these the aim of permitting earlier interven- ment. Investigator: Joseph L. Demer, syndromes have severe forms of stra- tion and improved disease monitor- MD, PhD bismus. Investigator: Joseph L. Demer, ing. Investigator: Alfredo A. Sadun, MD, PhD MD, PhD Optical Coherence Tomography Angiography Images of Hyaluronic Acid Gels for Upper Lid Observational Study of Patients Pregnant Women Retraction in Active State Thyroid Diagnosed with Idiopathic This study aims to identify changes Eye Disease Bilateral Cataracts that occur in the retina as a result of This study is to determine if hyaluronic The purpose of this study is to under- gestational associated diseases (eg, acid gel (HAG) can be used to cor- stand better how many people who gestational diabetes, high blood pres- rect upper eyelid retraction, improve have been diagnosed with early-onset sure, increased myopia) and unknown dry eye related symptoms, aesthetic idiopathic bilateral cataracts may have changes that may affect the eyes appearance, and quality of life in a rare but treatable disease called during gestation and in the two to three active-stage thyroid eye disease (TED). cerebrotendinous xanthomatosis (CTX). months following birth. Investigator: The study also aims to determine the Often one of the first signs of CTX is Irena Tsui, MD long-term outcome of TED and how cataract from an unknown cause at an long the effects of HAG can last. Inves- early age. Investigators: Federico G. tigator: Daniel B. Rootman, MD, MS Velez, MD, Stacy L. Pineles, MD, and Joseph L. Demer, MD, PhD Molecular and Cytogenetic Studies of Ocular Melanoma This research is to study ocular mela noma tumor tissue and to identify key molecular and genetic features that could help predict those patients who may be at high risk for metastasis. Investigators: Lynn K. Gordon, MD, PhD, Tara A. McCannel, MD, PhD, and Bradley R. Straatsma, MD, JD

82 UCLA STEIN EYE INSTITUTE | Research and Funding Optical Coherence Tomography Ptosis Surgery Outcomes Scale Characteristics of the Brow–Eyelid Angiography of Foveal Avascular Zone This investigation is to define and val- Margin Relationship in Premature Children idate a universal measure for ptosis The study purpose is to determine if This prospective study evaluates outcomes that can be used in defining changing the effect of gravity has an blood vessel development in chil- both value and efficacy in ptosis sur- effect on eyelid position. Investigators: dren and adults who are born early gery. Investigator: Daniel B. Rootman, Robert Alan Goldberg, MD, and Daniel and compares them with children and MD, MS B. Rootman, MD, MS adults who were not born early, by getting optical coherence tomogra- Studies on Tissue in Clinical Measurements of the phy (OCT), OCT-angiography, color Autoimmune Diseases Optic Nerve in Glaucoma pictures, refraction, and axial length This study aims to determine the cause The goal of this study is to develop on subjects with retinopathy of prema- of eye problems in Graves disease and novel structural measures of the optic turity and without retinopathy of pre- other autoimmune diseases. Examina- nerve and nerve fiber layer, which are maturity. Investigators: Irena Tsui, MD, tion is being done of material removed sensitive and specific for early and Stacy L. Pineles, MD, and Federico G. from orbits during surgical therapy progressive glaucomatous optic nerve Velez, MD for Graves disease or other problems damage. Investigators: Joseph Caprioli, requiring surgery on the tissue sur- MD, Anne L. Coleman, MD, PhD, and Pediatric Cornea and Anterior rounding the eyes, of thyroid tissue Simon K. Law, MD, PharmD Segment Diseases Registry removed during the course of surgical Pediatric cornea and anterior segment therapy, or of blood drawn for labo- Effect of Yoga on Glaucoma diseases are rarely encountered by ratory tests. Investigator: Robert Alan The purpose of this study is to exam- ophthalmologists. As such, details on Goldberg, MD ine the practice of yoga and its ability the causes, features, and optimal treat- to improve a patient’s vision by reliev- ment for these conditions are inade- Study of Macular Disease Using ing stress and reducing eye pres- quately described. The information on Spectral Domain Optical Coherence sure. Investigator: Anne L. Coleman, this registry would allow us to study Tomography Angiography (SD-OCTA) MD, PhD these diseases. Investigator: Simon The RTVue XR 100 Avanti with SSADA Fung, MD will be used to screen patients with Evaluating a Microshunt for the macular disease as detected with clin- Treatment of Glaucoma Pediatric Optic Neuritis Prospective ical examination or ancillary testing, This study is to assess the safety and Outcomes Study (PON1) such as with standard OCT, color fun- efficacy of a microshunt when used Optic neuritis is an acute inflammatory dus photography, fluorescein angiogra- to lower intraocular pressure (IOP) disease of the optic nerve. The pur- phy, or fundus autofluorescence. Inves- in subjects with primary open angle pose of this study is to collect infor- tigators: Michael B. Gorin, MD, PhD, glaucoma whose IOP is not controlled mation about children who have optic Colin A. McCannel, MD, David Sarraf, when using maximum-tolerated glau- neuritis and what happens to their eye- MD, and Steven D. Schwartz, MD coma medications. Investigators: sight. Investigator: Stacy L. Pineles, MD Joseph Caprioli, MD, Anne L. Coleman, Understanding the Genetics of MD, PhD, JoAnn A. Giaconi, MD, Simon PET/CT Imaging for Early Detection of Inherited Eye Disorders K. Law, MD, PharmD, and Brian A. Ocular Melanoma This study searches for the gene(s) Francis, MD, MS This research involves the use of com- responsible for inherited disorders bined positron emission tomogra- that are either specific to the eye or Glaucoma Imaging Study phy (PET)/computed tomography (CT) are part of the medical condition. The This study is evaluating different imag- scans in subjects with ocular mela- study provides for the clinical charac- ing techniques and their use in improv- noma to ideally develop better ways terization of affected individuals and ing open-angle glaucoma detection. of monitoring for tumor spread and at-risk family members, in conjunction Investigators: Kouros Nouri-Mahdavi, allow for early treatment if metastasis is with molecular genetic testing, to iden- MD, and Joseph Caprioli, MD found. Investigators: Tara A. McCannel, tify the causative genes and mutations. MD, PhD, and Bradley R. Straatsma, Investigators: Anthony J. Aldave, MD, Identifying Novel Genes for Fuchs MD, JD and Michael B. Gorin, MD, PhD Corneal Endothelial Dystrophy Investigators are working to identify Pro-Inflammatory Cytokines, Dry Eye, An Extended-Use Program of the gene(s) responsible for Fuchs cor- and Thyroid Eye Disease Elamipretide Topical Ophthalmic neal endothelial dystrophy, an inherited This study is to determine whether Solution for Patients with Leber disorder that may result in irreversible there are specific inflammatory proteins Hereditary Optic Neuropathy (LHON) corneal swelling and loss of vision. in tears of patients with active-stage This extended-use program is to pro- Investigators: Anthony J. Aldave, MD, thyroid eye disease (TED). If these vide elamipretide to patients with Gary N. Holland, MD, and Bartly J. inflammatory proteins exist, the study LHON previously enrolled in the Mondino, MD aims to determine whether they can SPILH‑201 clinical trial who are still ben- be used to predict dry eye symptom- efitting from treatment per the discre- atology and TED activity. Investigators: tion of the treating physician. Investiga- Robert Alan Goldberg, MD, and Daniel tors: Alfredo A. Sadun, MD, and Rustum B. Rootman, MD, MS Karanjia, MD

Research and Funding | UCLA STEIN EYE INSTITUTE 83 Long-term Follow-up of ND4 LHON Ocular Protrusion in Sitting and Role of Pattern Electroretinogram Subjects Treated with GS010 Supine Positions (PERG) in Glaucoma Ocular Gene Therapy in the The aim of this study is to compare the This study is researching the elec- RESCUE or REVERSE degree of ocular protrusion in normal trophysiological test, pattern electro- To assess the long-term safety of individuals and patients with thyroid retinogram (PERG) to determine the intravitreal GS010 administration up eye disease between sitting and lying role of PERG in estimating the risk of to five years post treatment in sub- (supine) positions. Investigators: Robert future glaucoma progression and the jects who were treated in the RESCUE Alan Goldberg, MD, and Daniel B. reversibility of glaucomatous dam- or REVERSE studies. Investigators: Rootman, MD, MS age after treatment. The latter could Alfredo A. Sadun, MD, and Rustum help clinicians better determine to Karanjia, MD Ocular Surface Microbiome Study what extent eye pressure needs to This study aims to investigate and be lowered to prevent disease pro- Natural History of the Progression understand the normal ecosystem of gression. Investigators: Joseph of Choroideremia microbes that live on the eye’s sur- Caprioli, MD, Anne L. Coleman, MD, This study characterizes the visual face and how their ecological system PhD, JoAnn A. Giaconi, MD, Simon function and retinal structural changes changes and responds to routine eye K. Law, MD, PharmD, and Kouros associated with X-linked choroidere- care and treatments. Investigators: Nouri-Mahdavi, MD mia with the intention of determining Hugo Hsu, MD, Vikas Chopra, MD, and the best means of measuring disease Gad Heilweil, MD Sweep Visual Evoked Potential for progression and the rate of natural Use in Amblyopia and Pediatric progression for this condition. Investi- Optic Nerve Appearance in Optic Nerve Disorders gators: Michael B. Gorin, MD, PhD, and Age-Related Macular Degeneration Using a new technique, investiga- Steven Nusinowitz, PhD In order to evaluate the relationship tors are measuring vision in preverbal between macular degeneration and children to diagnose and follow optic Natural History of the Progression of optic nerve change, digital imaging nerve diseases. Currently, treatment X-Linked Retinitis Pigmentosa technology and photography are being decisions are based on clinical exam- This study is to characterize the visual used to assess the structural appear- inations that are insensitive and reveal function and retinal structural changes ance of the optic nerve in patients vision loss well after permanent dam- associated with X-linked retinitis pig- with age-related macular degener- age has taken place. This technique mentosa to determine the best means ation. Investigator: Simon K. Law, allows more accurate examinations, of measuring disease progression MD, PharmD which leads to provision of treatments and the rate of natural progression for at the first signs of vision loss and this condition. Investigator: Michael B. Pediatric Cataract Surgery thereby decreases the risk of perma- Gorin, MD, PhD Outcomes Registry nent damage. Investigators: Joseph L. The study aim is to collect core clinical Demer, MD, PhD, Sherwin J. Isenberg, Neuroendocrine Tumor Metastases in data on children and teens undergoing MD, Stacy L. Pineles, MD, and Federico the Eye and Orbit surgery for cataracts in order to con- G. Velez, MD The purpose of this study is to under- duct analyses and generate hypoth- stand the diversity in presentation of eses. Clinical outcomes data will be Temporal Fossa in Different Ethnicities carcinoid tumors of the orbit, as well collected from affected subjects after The aim of this study is to investigate as to identify, stage, and grade related cataract surgery has been performed. differences in anatomy of tempo- factors that may affect prognosis and Investigators: Stacy L. Pineles, MD, and ral fossa between different ethnici- thus treatment decisions. Also con- Federico G. Velez, MD ties using three-dimensional CT scan sidered will be if there are features of images. Better knowledge of these carcinoid tumor presentations in the Research with Retinal Cells Derived differences is important for cosmetic orbit that can predict outcome and thus from Stem Cells for Dry Age-Related procedures to achieve better results guide therapeutic decision-making. Macular Degeneration (AMD) and fewer complications. Investiga- Investigator: Daniel B. Rootman, This study evaluates the long-term tors: Robert Alan Goldberg, MD, and MD, MS safety and tolerability of MA09- Catherine J. Hwang, MD hRPE cellular therapy in subjects with Ocular Hypertension Treatment Study advanced dry AMD from one to five Vision-Related Quality of Life and Since topical hypotensive medications years following the surgical proce- Ocular Dominance are safe and effective in delaying or dure to implant the MA09-hRPE cells. This study is designed to evaluate how preventing primary open angle glau- Investigators: Steven D. Schwartz, quality of life is impacted by glaucoma coma, this study is examining whether MD, Hamid Hosseini, MD, Jean-Pierre in relation to eye dominance. It aims other forms of treatment can be Hubschman, MD, Pradeep S. Prasad, to determine whether quality of life is deferred with little or no penalty. Inves- MD, MBA, and Irena Tsui, MD affected more by glaucoma if it primar- tigator: Anne L. Coleman, MD, PhD ily affects the dominant eye. Investi- gators: Joseph Caprioli, MD, Anne L. Coleman, MD, PhD, JoAnn A. Giaconi, MD, and Simon K. Law, MD, PharmD

84 UCLA STEIN EYE INSTITUTE | Research and Funding 2019–2020 Publications of the Full-Time Faculty

July 2019 Pool KL, Adachi K, Karnezis S, Salamon Shojaati G, Khandaker I, Funderburgh N, Romero T, Nielsen-Saines K, Pone S, ML, Mann MM, Basu R, Stolz DB, Strauss RW, Kong X, Ho A, Jha A, Boechat M, Aibe M, Gomes da Silva T, Geary ML, Dos Santos A, Deng SX, West S, Ip MS, Bernstein PS, Birch DG, Ribeiro CTM, Boechat MI, Brasil P, Zin Funderburgh JL. Mesenchymal Stem Cideciyan AV, Michaelides M, Sahel JA, A, Tsui I, Gaw SL, Daltro P, Ribeiro Cells Reduce Corneal Fibrosis and Sunness JS, Traboulsi EI, Zrenner E, BG, Fazecas T, Hygino da Cruz LC, Inflammation via Extracellular Vesicle- Pitetta S, Jenkins D, Hariri AH, Sadda Nogueira R, Vasconcelos Z, Pereira JP Mediated Delivery of miRNA. Stem SV, Scholl HPN, ProgStar Study Group. Jr, Saad Salles T, Barbosa CN, Chen W, Cells Transl Med. 2019 Nov;8(11):1192– Progression of Stargardt Disease Foo SS, Jung J, Moreira ME, Pone M. 1201. Epub 2019 Jul 10. as Determined by Fundus Autofluo Association Between Neonatal Neu- rescence Over a 12-Month Period: roimaging and Clinical Outcomes in Li J, Liu X, Abdelmohsen LKEA, ProgStar Report No. 11. JAMA Ophthal- Zika-Exposed Infants From Rio de Williams DS, Huang X. Spatial Orga- mol. 2019;137(10):1134–1145. Janeiro, Brazil. JAMA Netw Open. 2019 nization in Proteinaceous Membrane- Jul 3;2(7):e198124. Stabilized Coacervate Protocells. Small. Umapathy A, Williams DS. Live Imaging 2019 Sep;15(36):e1902893. Epub 2019 of Organelle Motility in RPE Flatmounts. Nielsen-Saines K, Brasil P, Kerin Jul 12. Adv Exp Med Biol. 2019;1185:389–393. T, Vasconcelos Z, Gabaglia CR, Damasceno L, Pone M, Abreu de Tsui E, Leong BCS, Mehta N, Gupta A, Dos Santos A, Balayan A, Funderburgh Carvalho LM, Pone SM, Zin AA, Tsui I, Goduni L, Cunningham ET Jr, Freund ML, Ngo J, Funderburgh JL, Deng SX. Salles TRS, da Cunha DC, Costa RP, KB, Lee GD, Dedania VS, Yannuzzi LA, Differentiation Capacity of Human Mes- Malacarne J, Reis AB, Hasue RH, Modi YS. Evaluation of segmental ret- enchymal Stem Cells into Keratocyte Aizawa CYP, Genovesi FF, Einspieler C, inal arteritis with optical coherence Lineage. Invest Ophthalmol Vis Sci. Marschik PB, Pereira JP, Gaw SL, tomography angiography. Retin Cases 2019 Jul 1;60(8):3013–3023. Adachi K, Cherry JD, Xu Z, Cheng Brief Rep. 2019 Jul 15. Nassisi M, Tepelus T, Nittala MG, G, Moreira ME. Delayed childhood Thanos A, Shwayder T, Papakostas TD, Sadda SR. Choriocapillaris flow impair- neurodevelopment and neurosen- Corradetti G, Capone A Jr, Sarraf D, ment predicts the development and sory alterations in the second year of Shields CL, Trese MT. Retinal Vascular enlargement of drusen. Graefes life in a prospective cohort of ZIKV- Abnormalities in Phakomatosis Pigmen- Arch Clin Exp Ophthalmol. 2019 Oct; exposed children. Nat Med. 2019 Aug; tovascularis. Ophthalmol Retina. 2019 257(10):2079–2085. Epub 2019 Jul 1. 25(8):1213–1217. Epub 2019 Jul 8. Dec;3(12):1098–1104. Epub 2019 Jul 16. Le Q, Chauhan T, Deng SX. Diagnostic Wang T, Pahlberg J, Cafaro J, González S, Uhm H, Deng SX. Notch criteria for limbal stem cell deficiency Frederiksen R, Cooper AJ, Sampath Inhibition Prevents Differentiation of before surgical intervention—A system- AP, Field GD, Chen J. Activation of Rod Human Limbal Stem/Progenitor Cells in atic literature review and analysis. Input in a Model of Retinal Degenera- vitro. Sci Rep. 2019 Jul 17;9(1):10373. Surv Ophthalmol. 2020 Jan–Feb; tion Reverses Retinal Remodeling and 65(1):32–40. Epub 2019 Jul 2. Review. Induces Formation of Functional Syn- apses and Recovery of Visual Signaling Tsui E, Gonzales JA. Retinal Vasculi- tis Associated with Ipilimumab. Ocul Francone A, Huang JM, Ma J, Tsao TC, in the Adult Retina. J Neurosci. 2019 Immunol Inflamm. 2019 Jul 17:1–3. Rosen J, Hubschman JP. The Effect Aug 21;39(34):6798–6810. Epub 2019 Jul 8. of Haptic Feedback on Efficiency and Sadda SR, Campbell J, Dugel PU, Safety During Preretinal Membrane Holekamp NM, Kiss S, Loewenstein A, Peeling Simulation. Transl Vis Sci Bai X, Yang XJ, Chen L. Generation of an integration-free induced pluripotent Augustin AJ, Shih V, Xu X, Wykoff CC, Technol. 2019 Jul 3;8(4):2. eCollection Whitcup SM. Relationship between 2019. stem cell line (FDEENTi003-A) from a patient with pathological myopia. Stem duration and extent of oedema and visual acuity outcome with ranibizumab Mason AF, Yewdall NA, Welzen PLW, Cell Res. 2019 Aug;39:101495. Epub in diabetic macular oedema: A post Shao J, van Stevendaal M, van Hest 2019 Jul 9. hoc analysis of Protocol I data. Eye JCM, Williams DS, Abdelmohsen (Lond). 2020 Mar;34(3):480–490. Epub LKEA. Mimicking Cellular Compart- Wu Y, Seong YJ, Li K, Choi D, Park E, 2019 Jul 18. mentalization in a Hierarchical Protocell Daghlian GH, Jung E, Bui K, Zhao L, through Spontaneous Spatial Orga- Madhavan S, Daghlian S, Daghlian P, nization. ACS Cent Sci. 2019 Aug 28; Chin D, Cho IT, Wong AK, Heur M, 5(8):1360–1365. Epub 2019 Jul 3. Zhang-Nunes S, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. Organogen- esis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. 2020 Jul 9;5(13).

Research and Funding | UCLA STEIN EYE INSTITUTE 85 Govetto A, Hubschman JP, Sarraf D, Bellemo V, Lim G, Rim TH, Tan GSW, Au A, Hou K, Dávila JP, Gunnemann Figueroa MS, Bottoni F, dell’Omo R, Cheung CY, Sadda S, He MG, Tufail A, F, Fragiotta S, Arya M, Sacconi R, Curcio CA, Seidenari P, Delledonne G, Lee ML, Hsu W, Ting DSW. Artificial Pauleikhoff D, Querques G, Waheed Gunzenhauser R, Ferrara M, Au A, Intelligence Screening for Diabetic N, Freund KB, Sadda S, Sarraf D. Volu- Virgili G, Scialdone A, Repetto R, Retinopathy: The Real-World Emerging metric Analysis of Vascularized Serous Romano MR. The role of Müller cells in Application. Curr Diab Rep. 2019 Jul 31; Pigment Epithelial Detachment Pro- tractional macular disorders: an opti- 19(9):72. gression in Neovascular Age-Related cal coherence tomography study and Macular Degeneration Using Optical physical model of mechanical force Shi Y, Yang X, Marion KM, Francis BA, Coherence Tomography Angiography. transmission. Br J Ophthalmol. 2020 Sadda SR, Chopra V. Novel and Semi- Invest Ophthalmol Vis Sci. 2019 Aug 1; Apr;104(4):466–472. Epub 2019 Jul 20. automated 360-Degree Gonioscopic 60(10):3310–3319. Clinical Trial. Anterior Chamber Angle Imaging in Tsui E, Goldberg NR, Pillai C, Goduni Under 60 Seconds. Ophthalmol Glau- Strauss RW, Kong X, Ho A, Jha A, L, Freund KB. Multimodal imaging of coma Jul–Aug 2019;2(4):215–223. West S, Ip M, Bernstein PS, Birch DG, IgG4-related papillitis and retinal dis- Cideciyan AV, Michaelides M, Sahel JA, ease. Retin Cases Brief Rep. 2019 Sunness JS, Traboulsi EI, Zrenner E, August 2019 Jul 22. Pitetta S, Jenkins D, Hariri AH, Sadda Essilfie JO, Kattan J, Demer JL, S, Scholl HPN; ProgStar Study Group. Wykoff CC, Nittala MG, Zhou B, Fan W, Rootman DB. Cross-Sectional Soft- Progression of Stargardt Disease as Velaga SB, Lampen SIR, Rusakevich Tissue Composition and the Distribu- Determined by Fundus Autofluores- AM, Ehlers JP, Babiuch A, Brown DM, tion of Blue Cutaneous Discoloration in cence Over a 12-Month Period: Prog- Ip MS, Sadda SR; Intravitreal Afliber- the Lower Eyelid after Hyaluronic Acid Star Report No. 11. JAMA Ophthalmol. cept for Retinal Nonperfusion in Pro- Injection. Plast Reconstr Surg. 2019 2019 Aug 1. liferative Diabetic Retinopathy Study Aug;144(2):336–339. Clinical Trial. Group. Intravitreal Aflibercept for Ret- Cao S, Shao J, Xia Y, Che H, Zhong Z, inal Nonperfusion in Proliferative Dia- Huang AS, Stenger MB, Macias BR. Meng F, van Hest JCM, Abdelmohsen betic Retinopathy: Outcomes from the Gravitational Influence on Intraocular LKEA, Williams DS. Molecular Pro Randomized RECOVERY Trial. 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Assessing Retrobulbar Than 100,000 Consecutive Encounters Wykoff CC, Brown DM, Van Hemert J, Hyaluronidase as a Treatment for from People with Diabetes. Diabetes Sagong M, Sadda SR, Ip M. Severity Filler-Induced Blindness in a Cadaver Technol Ther. 2019 Nov;21(11):635–643. of Diabetic Macular Edema Correlates Model. Plast Reconstr Surg. 2019 Aug; Epub 2019 Aug 7. with Retinal Vascular Bed Area on 144(2):315–320. Ultra-Wide Field Fluorescein Angiogra- Karlin JN, Rootman DB. Brow height phy: DAVE Study. Retina. 2019 Jul 26. Sarraf D. Ocular imaging in the Cana- asymmetry before and after eyelid pto- dian Journal of Ophthalmology. Can J sis surgery. J Plast Reconstr Aesthet Handa JT, Bowes Rickman C, Dick AD, Ophthalmol. 2019 Aug;54(4):410. Surg. 2020 Feb;73(2):357–362. Epub Gorin MB, Miller JW, Toth CA, Ueffing 2019 Aug 8. M, Zarbin M, Farrer LA. A systems Sultan W, Asanad S, Karanjia R, Sadun biology approach towards under- AA. Long-term attenuation of the Iovino C, Au A, Sarraf D. Fundus auto standing and treating non-neovascular deep capillary plexus in SLE utilizing fluorescence of bilateral ora serrata age-related macular degeneration. OCTA. Can J Ophthalmol. 2019 Aug; pearls. Can J Ophthalmol. 2020 Feb; Nat Commun. 2019 Jul 26;10(1):3347. 54(4):e207–e212. 55(1):e20–e22. Epub 2019 Aug 9. Review. Zhang W, Margines JB, Jacobs DS, Warmack RA, Shawa H, Liu K, Saha S, Nassisi M, Wang M, Lindenberg Rabinowitz YS, Hanser EM, Chauhan T, Lopez K, Loo JA, Horwitz J, Clarke S, Kanagasingam Y, Sadda S, Hu ZJ. Chung D, Bykhovskaya Y, Gaster RN, SG. The l-isoaspartate modifica- Automated Detection and Classifica- Aldave AJ. Corneal Perforation After tion within protein fragments in the tion of Early AMD Biomarkers Using Corneal Cross-Linking in Keratoconus aging lens can promote protein Deep Learning. Sci Rep. 2019 Jul 29; Associated With Potentially Pathogenic aggregation. J Biol Chem. 2019 Aug 9(1):10990. ZNF469 Mutations. 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86 UCLA STEIN EYE INSTITUTE | Research and Funding Bogarin T, Saraswathy S, Akiyama G, Lee OL, Shi Y, Brown T, Maram J. Heuzé ML, Sankara Narayana GHN, Xie X, Weinreb RN, Zheng J, Huang Quantifying the Size of the Pterygium D’Alessandro J, Cellerin V, Dang T, AS. Cellular and cytoskeletal alter- Head by Evaluating the Fibrous Area or Williams DS, Van Hest JC, Marcq P, ations of scleral fibroblasts in response the Vascularized Area. Cornea. 2020 Mège RM, Ladoux B. Myosin II isoforms to glucocorticoid steroids. Exp Eye Sep;39(9):1069–1072. play distinct roles in adherens junction Res. 2019 Oct;187:107774. Epub 2019 biogenesis. Elife. 2019 Sep 5;8:e46599. Aug 23. Murthy R, Roos JCP, Goldberg RA. Periocular hyaluronic acid fillers: Piccolo P, Sabatino V, Mithbaokar P, Pflugfelder SC, Massaro-Giordano applications, implications, complica- Polishchuck E, Law SK, Magraner- M, Perez VL, Hamrah P, Deng SX, tions. Curr Opin Ophthalmol. 2019 Pardo L, Pons T, Polishchuck R, Espandar L, Foster CS, Affeldt J, Sep;30(5):395–400. Brunetti-Pierri N. Geleophysic dys- Seedor JA, Afshari NA, Chao W, plasia: novel missense variants and Allegretti M, Mantelli F, Dana R. Topi- Snyder KC, Oikawa K, Williams J, Kiland insights into ADAMTSL2 intracellu- cal Recombinant Human Nerve Growth JA, Gehrke S, Teixeira LBC, Huang AS, lar trafficking. Mol Genet Metab Rep. Factor (Cenegermin) for Neurotrophic McLellan GJ. Imaging Distal Aqueous 2019 Sep 5;21:100504. eCollection Keratopathy: A Multicenter Random- Outflow Pathways in a Spontaneous 2019 Dec. ized Vehicle-Controlled Pivotal Trial. Model of Congenital Glaucoma. Transl Ophthalmology. 2020 Jan;127(1):14–26. Vis Sci Technol. 2019 Sep;8(5):22. Singh MS, Park SS, Albini TA, Epub 2019 Aug 26. Clinical Trial. eCollection 2019 Sep. Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz Fan W, Nittala MG, Fleming A, Tran TM, Duong H, Bonnet C, SD, Bharti K. Retinal stem cell trans- Robertson G, Uji A, Wykoff CC, Brown Kashanchi A, Buckshey A, Aldave AJ. plantation: Balancing safety and poten- DM, van Hemert J, Ip M, Wang K, Corneal Blindness in Asia: A Systematic tial. Prog Retin Eye Res. 2020 Mar; Falavarjani KG, Singer M, Sagong M, Review and Meta-Analysis to Identify 75:100779. Epub 2019 Sep 5. Review. Sadda SR. Relationship Between Challenges and Opportunities. Cornea. Retinal Fractal Dimension and Non- 2020 Sep;39(9):1196–1205. Francone A, Essilfie J,Sarraf D, Preti perfusion in Diabetic Retinopathy on RC, Monteiro MLR, Hubschman JP. Ultrawide-Field Fluorescein Angiog- Nittala MG, Velaga SB, Hariri A, Pfau M, Effect of laser photocoagulation on raphy. Am J Ophthalmol. 2020 Jan; Birch DG, Haines J, Pericak-Vance MA, macular edema associated with macu- 209:99–106. Epub 2019 Aug 29. 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Epub 2019 Facial numbness in the ophthalmology Observations From Ultra-Widefield Sep 10. clinic. A portentous sign. Eye (Lond). Fundus Imaging. Ophthalmic Surg 2020 Apr;34(4):663–668. Epub 2019 Lasers Imaging Retina. 2019 Sep 1; Rabiolo A, Morales E, Mohamed L, Aug 30. 50(9):557–564. Clinical Trial. Capistrano V, Kim JH, Afifi A, Yu F, Coleman AL, Nouri-Mahdavi K, Williams DS, Mouradov D, Browne C, Francis BA, Flowers B, Dastiridou A, Caprioli J. Comparison of Methods to Palmieri M, Elliott MJ, Nightingale R, Yelenskiy A, Chopra V, Alvarado JA. Detect and Measure Glaucomatous Fang CG, Li R, Mariadason JM, Endoscopic Cyclophotocoagulation Visual Field Progression. Transl Vis Sci Faragher I, Jones IT, Churilov L, and Other Cyclodestructive Methods: Technol. 2019 Sep 11;8(5):2. eCollection Tebbutt NC, Gibbs P, Sieber OM. 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Research and Funding | UCLA STEIN EYE INSTITUTE 87 Goseki T, Suh SY, Robbins L, Pineles Guymer RH, Rosenfeld PJ, Curcio CA, Daniele LL, Caughey J, Volland S, SL, Velez FG, Demer JL. Prevalence Holz FG, Staurenghi G, Freund KB, Sharp RC, Dhingra A, Williams DS, of Sagging Eye Syndrome in Adults Schmitz-Valckenberg S, Sparrow J, Philp NJ, Boesze-Battaglia K. Peroxi- with Binocular Diplopia. Am J Ophthal- Spaide RF, Tufail A, Chakravarthy U, some turnover and diurnal modulation mol. 2020 Jan;209:55–61. Epub 2019 Jaffe GJ, Csaky K, Sarraf D, Monés JM, of antioxidant activity in retinal pig- Sep 14. Tadayoni R, Grunwald J, Bottoni F, ment epithelia utilizes microtubule- Liakopoulos S, Pauleikhoff D,Pagliarini associated protein 1 light chain 3B Asanad S, Lo C, Ugradar S, Rootman S, Chew EY, Viola F, Fleckenstein M, (LC3B). Am J Physiol Cell Physiol. 2019 DB. Invasive cavernous sinus asper- Blodi BA, Lim TH, Chong V, Lutty J, Bird Dec 1;317(6):C1194–C1204. Epub 2019 gillosis: an orbitocranial approach for AC, Sadda SR. Incomplete Retinal Pig- Oct 2. diagnosis and management. Can J ment Epithelial and Outer Retinal Atro- Ophthalmol. 2020 Feb;55(1):e33–e36. phy in Age-Related Macular Degener- Yang U, Gentleman S, Gai X, Gorin MB, Epub 2019 Sep 16. ation: Classification of Atrophy Meeting Borchert MS, Lee TC, Villanueva A, Report 4. Ophthalmology. 2020 Mar; Koenekoop R, Maguire AM, Bennett J, Mao X, An Q, Xi H, Yang XJ, Zhang X, 127(3):394–409. Epub 2019 Sep 30. Redmond TM, Nagiel A. Utility of In Yuan S, Wang J, Hu Y, Liu Q, Fan G. Vitro Mutagenesis of RPE65 Protein for Single-Cell RNA Sequencing of hESC- Verification of Mutational Pathogenicity October 2019 Derived 3D Retinal Organoids Reveals Before Gene Therapy. JAMA Ophthal- Novel Genes Regulating RPC Commit- McCannel CA, McCannel TA. A mol. 2019 Oct 3;137(12):1–9. ment in Early Human Retinogenesis. 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90 UCLA STEIN EYE INSTITUTE | Research and Funding Sarraf D, Sadda S. Pearls and Pitfalls of Gorin MB, daSilva MJ. Predictive Chen L, Messinger JD, Zhang Y, Optical Coherence Tomography Angi- genetics for AMD: Hype and hopes for Spaide RF, Freund KB, Curcio CA. ography Image Interpretation. JAMA genetics-based strategies for treat- Subretinal drusenoid deposit in age- Ophthalmol. 2019 Dec 5. ment and prevention. Exp Eye Res. related macular degeneration: Histo- 2020 Feb;191:107894. Epub 2019 Dec logic insights into initiation, progression Ugradar S, Le A, Lesgart M, Goldberg 17. Review. to atrophy, and imaging. Retina. 2020; RA, Rootman D, Demer JL. Biome- 40(4):618–631. chanical and Morphologic Effects of Govetto A, Sarraf D, Hubschman JP, Collagen Cross-Linking in Human Tar- Tadayoni R, Couturier A, Chehaibou I, Truong DT, Miller KM. Chapter 9, Iris sus. Transl Vis Sci Technol. 2019 Dec 5; Au A, Grondin C, Virgili G, Romano MR. Prosthesis Devices. 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Research and Funding | UCLA STEIN EYE INSTITUTE 91 Wang D, Au A, Gunnemann F, Hilely A, Verma A, Alagorie AR, Ramasamy K, Rowlands MA, Patel P, Dubovy SR, Chiu Scharf J, Tran K, Sun M, Kim JH, Sarraf van Hemert J, Yadav NK, Pappuru RR, B, Tsui E, Solomon J, Modi YS. Ectopic D. Pentosan-associated maculopathy: Tufail A, Nittala MG, Sadda SR, Raman Retinal Pseudocysts: A Clinicopatho- prevalence, screening guidelines, and R; Indian Retina Research Associ- logic Correlation. Ophthalmol Retina. spectrum of findings based on pro- ates (IRRA). Distribution of peripheral 2019 Jul;3(7):616–617. Epub 2019 spective multimodal analysis. Can J lesions identified by mydriatic ultra- Feb 5. Ophthalmol. 2020 Apr;55(2):116–125. wide field fundus imaging in diabetic Epub 2020 Jan 20. retinopathy. Graefes Arch Clin Exp Scharf JM, Hilely A, Freund KB, Sarraf Ophthalmol. 2020 Apr;258(4):725–733. D. Autofluorescent timeline of spots Gordon LK, Danesh-Meyer H. Neuro- Epub 2020 Jan 27. and dots in multiple evanescent white Ophthalmic Manifestations of HIV dot syndrome. Retin Cases Brief Rep. Infection. Ocul Immunol Inflamm. 2020 Azhdam AM, Goldberg RA, Ugradar S. 2020 Feb 5. Jan 21:1–9. In Vivo Measurement of the Human Vitreous Chamber Volume Using Com- Williams DS. Hepatic Adenoma. J Insur Parravano M, Costanzo E, Borrelli E, puted Tomography Imaging of 100 Med. 2020 Feb 5. Sacconi R, Virgili G, Sadda SR, Scarinci Eyes. Transl Vis Sci Technol. 2020 Jan F, Varano M, Bandello F, Querques 29;9(1):2. eCollection 2020 Jan. Law SK, Wang L, Li T. Acupuncture for G. Appearance of cysts and capillary glaucoma. Cochrane Database Syst non perfusion areas in diabetic mac- Saravanan VR, Manayath GJ, Balan R, Rev. 2020 Feb 7;2(2):CD006030. ular edema using two different OCTA Ranjan R, Freund KB, Sarraf D. Diag- devices. Sci Rep. 2020 Jan 21;10(1):800. nostic and Therapeutic Challenges. Xiong YZ, Kwon M, Bittner AK, Virgili Retina. 2020 Jan 30. G, Giacomelli G, Legge GE. Relation- Mohammadzadeh V, Rabiolo A, Fu ship Between Acuity and Contrast Q, Morales E, Coleman AL, Law SK, Strunz T, Lauwen S, Kiel C; Interna- Sensitivity: Differences Due to Eye Dis- Caprioli J, Nouri-Mahdavi K. Longitu- tional AMD Genomics Consortium ease. Invest Ophthalmol Vis Sci. 2020 dinal Macular Structure-Function Rela- (Gorin MB), Hollander AD, Weber BHF. Feb 7;61(2):40. tionships in Glaucoma. Ophthalmology. A transcriptome-wide association 2020 Jul;127(7):888–900. Epub 2020 study based on 27 tissues identifies Milstein ML, Cavanaugh BL, Roussey Jan 22. 106 genes potentially relevant for dis- NM, Volland S, Williams DS, Goldberg ease pathology in age-related macular AFX. Multistep peripherin-2/rds self- Patel SH, Truong T, Tsui I, Moon JY, degeneration. Sci Rep. 2020 Jan 31; assembly drives membrane curvature Rosenberg JB. Gender of Presenters at 10(1):1584. for outer segment disk architecture and Ophthalmology Conferences Between photoreceptor viability. Proc Natl Acad 2015 and 2017. Am J Ophthalmol. 2020 Sung Y, Goldberg RA, Lew H. Perior- Sci U S A. 2020 Feb 25;117(8):4400– May;213:120–124. Epub 2020 Jan 23. bital Injection of Hyaluronic Acid Gel 4410. Epub 2020 Feb 10. in Patients With Deep Superior Sulcus. Patel KS, Kejriwal S, Sun MM, J Craniofac Surg. 2020 Jan/Feb; Sadda SR. Lack of efficacy of epler- Thammachantha S, Duong C, Chan A, 31(1):271–273. enone for treatment of active central Cherian N, Romiyo P, Gordon LK, Yong serous chorioretinopathy. Eye (Lond). W, Wadehra M, Yang I. Identification of 2020 Feb 10. February 2020 epithelial membrane protein 2 (EMP2) as a molecular marker and correlate Sadda SR. A path to the development Ugradar S, Isse N, Goldberg RA, for angiogenesis in meningioma. J of screening guidelines for pentosan Fodor P. A novel variation of the suture Neurooncol. 2020 Mar;147(1):15–24. maculopathy. Can J Ophthalmol. 2020 suspension facelift. J Cosmet Dermatol. Epub 2020 Jan 24. Feb;55(1):1–2. 2020 Feb 10.

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92 UCLA STEIN EYE INSTITUTE | Research and Funding Williams DS, Mouradov D, Newman Zupancic JAF, Ying GS, de Alba Le A, Shin A, Park J, Poukens V, Demer MR, Amini E, Nickless DK, Fang CG, Campomanes, Tomlinson LA, JL. Bilaminar Structure of the Human Palmieri M, Sakthianandeswaren A, Binenbaum G, G-ROP Study Group Optic Nerve Sheath. Curr Eye Res. Li S, Ward RL, Hawkins NJ, Skinner I, (Khitri MR). Evaluation of the economic 2020 Jul;45(7):864–872. Epub 2020 Jones I, Gibbs P, Sieber OM. Tumour impact of modified screening criteria Mar 16. infiltrating lymphocyte status is supe- for retinopathy of prematurity from the rior to histological grade, DNA mis- Postnatal Growth and ROP (G-ROP) Dong PN, Cung LX, Sam TK, Hang DTT, match repair and BRAF mutation for study. J Perinatol. 2020 Jul;40(7):1100– Chung DD, Alkadi TA, Buckshey A, prognosis of colorectal adenocarcino- 1108. Epub 2020 Feb 28. Zhang J, Kassels A, Aldave AJ. Iden- mas with mucinous differentiation. 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Research and Funding | UCLA STEIN EYE INSTITUTE 93 Lenis TL, Gunzenhauser RC, Fung Velaga SB, Nittala MG, Vupparaboina Karlin JN, Mustak H, Gupta A, Ramos SSM, Dhindsa YK, Sarraf D, Pineles KK, Jana S, Chhablani J, Haines J, R, Rootman DB. Cone Beam Comput- SL, Tsui I. Myopia and anterior seg- Pericak-Vance MA, Stambolian D, erized Tomography Dacryocystogra- ment optical coherence tomography Sadda SR. Choroidal vascularity index phy (CBCT DCG) for the Evaluation of findings in laser-treated retinopathy of and choroidal thickness in eyes with Lacrimal Drainage System Dysfunction. prematurity eyes. J AAPOS. 2020 Apr; reticular pseudodrusen. Retina. 2020 Ophthalmic Plast Reconstr Surg. 2020 24(2):86. e1–86. e7. Epub 2020 Mar 26. Apr;40(4):612–617. Apr 3.

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94 UCLA STEIN EYE INSTITUTE | Research and Funding Liang Q, Le Q, Cordova DW, Tseng CH, Zhang C, Mei H, Robertson SYT, Lee Yu HJ, Kaier PK, Zamora D, Bocanegra Deng SX. Corneal Epithelial Thickness HJ, Deng SX, Zheng JJ. A Small- M, Cone C, Brown DM, Sadda SR, Measured Using AS-OCT as a Diag- Molecule Wnt Mimic Improves Human Wycoff CC. Visual Acuity Variability: nostic Parameter for Limbal Stem Cell Limbal Stem Cell Ex Vivo Expansion. Comparing Discrepancies Between Deficiency. Am J Ophthalmol. 2020 Apr iScience. 2020 May 22;23(5):101075. Snellen and ETDRS Measurements 10:S0002-9394(20)30173-2. Epub 2020 Apr 18. Among Subjects Entering Prospective Trials. Ophthalmol Retina. 2020 Apr 23; Tran J, Tsui E. Assessment of the Khan M, Cornelis SS, Pozo-Valero MD, S2468-6530(20)30154-8. 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Research and Funding | UCLA STEIN EYE INSTITUTE 95 May 2020 Akiyama G, Saraswathy S, Bogarin T, Au A, Hilely A, Scharf J, Gunnemann Pan X, Barron E, Wong TT, Kaneko MK, F, Wang D, Chehaibou I, Iovino C, Francone A, Kothari N, Farajzadeh M, Kato Y, Hong Y, Huang AS. Functional, Grondin C, Farecki ML, Falavarjani KG, Hosseini H, Prasad P, Schwartz S, structural, and molecular identifica- Phasukkijwatana N, Battista M, Borrelli Hubschman JP. Detection of neuro- tion of lymphatic outflow from subcon- E, Sacconi R, Powell B, Hom G, sensory retinal detachment compli- junctival blebs. Exp Eye Res. 2020 Jul; Greenlee TE, Conti TF, Ledesma-Gil cating degenerative retinoschisis by 196:108049. Epub 2020 May 6. G, Teke MY, Choudhry N, Fung AT, ultra-widefield fundus autofluores- Krivosic V, Baek J, Lee MY, Sugiura Y, cence imaging. Retina. 2020 May; Baumal CR, Sarraf D, Bryant T, Gui Querques G, Peiretti E, Rosen R, Lee 40(5):819–824. W, Muakkassa N, Pichi F, Querques WK, Yannuzzi LA, Zur D, Loewenstein G, Choudhry N, Teke MY, Govetto A, A, Pauleikhoff D, Singh R, Modi Y, Silkiss RZ, Paap MK, Ugradar S, Milman Invernizzi A, Eliott D, Gaudric A, Cunha Hubschman JP, Ip M, Sadda S, Freund T. Discussion: Assessing Retrobulbar de Souza E, Naysan J, Lembo A, Lee KB, Sarraf D. Relationship Between Hyaluronidase as a Treatment for GC, Freund KB. Henle fibre layer hae- Nerve Fiber Layer Hemorrhages and Filler-Induced Blindness in a Cadaver morrhage: clinical features and patho- Outcomes in Central Retinal Vein Model and Video Discussion: Treat- genesis. Br J Ophthalmol. 2020 May 6: Occlusion. Invest Ophthalmol Vis Sci. ment for Filler-Induced Blindness. bjophthalmol-2019-315443. 2020 May 11;61(5):54. Plast Reconstr Surg. 2020 May; 145(5):999e–1001e. Burger CA, Alevy J, Casasent AK, Jiang Chen JY, Le A, Caprioli J, Giaconi JA, D, Albrecht NE, Liang JH, Hirano AA, Nouri-Mahdavi K, Law SK, Bonelli L, Sun Y, Yung M, Huang L, Tseng C, Brecha NC, Samuel MA. LKB coordi- Coleman AL, Demer JL. Orbital Fat Deng SX. Limbal Stem Cell Deficiency 1 nates neurite remodeling to drive syn- Volume After Treatment with Topical After Glaucoma Surgery. Cornea. 2020 apse layer emergence in the outer ret- Prostaglandin Agonists. Invest Ophthal- May;39(5):566–572. ina. Elife. 2020 May 7;9:e56931. mol Vis Sci. 2020 May 11;61(5):46. Lee YH, Maniglia M, Velez F, Demer JL, Echols BS, Clark ME, Swain TA, Chen L, Moxon NR, Goyal A, Giaconi Seitz AR, Pineles S. Short-term Percep- Kar D, Zhang Y, Sloan KR, McGwin G JA, Rosenberg JB, Graubart EB, tual Learning Game Does Not Improve Jr, Singireddy R, Mays C, Kilpatrick D, Waxman EL, Knoch D, Forster SH, Patching-Resistant Amblyopia in Older Crosson JN, Owsley C, Curcio CA. Sankar PS, Mirza RG. The State of Children. J Pediatr Ophthalmol Strabis- Hyperreflective foci and specks are Ophthalmology Medical Student mus. 2020 May 1;57(3):176–184. associated with delayed rod-mediated Education in the United States: An dark adaptation in non-neovascular Hall V, Trubiano JA, Kwong JC, Update. Ophthalmology. 2020 May 11: age-related macular degeneration. Williams DS, Holmes NE. Immunosup- S0161-6420(20)30425-5. Ophthalmology Retina. 2020 May 7. pressed Returned Traveler With Ulcer- Sobhani NC, Avvad-Portari E, ating Skin Lesion and Fever. Clin Infect Jung JJ, Yu DJG, Zeng A, Chen MH, Nascimento ACM, Machado HN, Dis. 2019 May 2;68(10):1747–1749. Shi Y, Nassisi M, Marion KM, Sadda SR, Lobato DSS, Pereira JP, Esquivel MS, Hoang QV. Correlation of Quantita- Uji A, Sadda SR, Muraoka Y, Kadomoto Vasconcelos ZC, Zin AA, Tsui I, tive Measurements with Diabetic Dis- S, Ooto S, Murakami T, Akagi T, Miyata Adachi K, Brickley EB, Fisher SJ, ease Severity Using Multiple En Face M, Tsujikawa A. Effect of image aver- Nielsen-Saines K, Brasil P, Moreira ME, OCT Angiography Image Averaging. aging on optical coherence tomog- Gaw SL. Discordant Zika Virus Findings Ophthalmol Retina. 2020 May 7: raphy angiography data in eyes with in Twin Pregnancies Complicated by S2468-6530(20)30192-5. branch retinal vein occlusion. Graefes Antenatal Zika Virus Exposure: A Pro- Arch Clin Exp Ophthalmol. 2020 Aug; spective Cohort. J Infect Dis. 2020 May Schönbach EM, Strauss RW, Ahmed 258(8):1639–1648. Epub 2020 May 2. 11;221(11):1838–1845. MI, Janes JL, Cideciyan AV, Birch DG, Sunness JS, Zrenner E, Ip MS, Kong X, Frausto RF, Swamy VS, Peh GSL, Boere Sreekumar PG, Wang M, Spee C, Sadda SR, Scholl HPN; ProgStar PM, Hanser EM, Chung DD, George BL, Sadda SR, Kannan R. Transporter- study group. The Effect of Attention Morselli M, Kao L, Azimov R, Wu J, Mediated Mitochondrial GSH Depletion on Fixation Stability during Dynamic Pellegrini M, Kurtz I, Mehta JS, Aldave Leading to Mitochondrial Dysfunction Fixation Testing in Stargardt Dis- AJ. Phenotypic and functional charac- and Rescue with αB Crystallin Peptide ease. Am J Ophthalmol. 2020 May 10: terization of corneal endothelial cells in RPE Cells. Antioxidants (Basel). 2020 S0002-9394(20)30230-0. during in vitro expansion. Sci Rep. May 12;9(5):411. 2020 May 4;10(1):7402. Choudhry N, Duker JS, Freund KB, Chang MY, Binenbaum G, Heidary G, Kiss S, Querques G, Rosen R, Sarraf D, Morrison DG, Galvin JA, Trivedi RH, Souied EH, Stanga PE, Staurenghi G, Pineles SL. Imaging Methods for Dif- Sadda SR. Classification and Guide- ferentiating Pediatric Papilledema lines for Widefield Imaging: Recom- from Pseudopapilledema: A Report by mendations from the International the American Academy of Ophthal- Widefield Imaging Study Group. Oph- mology. Ophthalmology. 2020 May 5: thalmol Retina. 2019 Oct;3(10):843– S0161-6420(20)30276-1. 849. Epub 2019 May 13.

96 UCLA STEIN EYE INSTITUTE | Research and Funding Mahmoudinezhad G, Lin M, Rabiolo Byon I, Alagorie AR, Ji Y, Su L, Nassisi M, Lei J, Abdelfattah NS, A, Morales E, Hirunpatravong P, Sadda SR. Am J Ophthalmol. Opti- Karamat A, Balasubramanian S, Fan W, Sharifipour F, Caprioli J. Rate of mizing the Repeatability of Chorio- Uji A, Marion KM, Baker K, Huang X, visual field decay in glaucomatous capillaris Flow Deficit Measurement Morgenthien E, Sadda SR. OCT Risk eyes with acquired pits of the optic from Optical Coherence Tomog- Factors for Development of Late Age- nerve. Br J Ophthalmol. 2020 May 13: raphy Angiography. 2020 May 23: Related Macular Degeneration in the bjophthalmol-2020-315980. S0002-9394(20)30266-X. Fellow Eyes of Patients Enrolled in the HARBOR Study. Ophthalmology. 2019 Cohen LM, Campbell BC, Esfandiari M, Bonnet C, Debillon L, Al-Hashimi S, Dec;126(12):1667–1674. Epub 2019 May Goldberg RA, Rootman DB. Ophthal- Hoogewoud F, Monnet D, Bourges JL, 29. 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J Binocul Vis Ocul Motil. 2020 Paap MK, Milman T, Ugradar S, Jul–Sep;70(3):79–85. Epub 2020 Pineles SL, Chang MY, Velez FG. Com- Goldberg R, Silkiss RZ. Examining May 15. partmental Strabismus. J Binocul Vis the Role of Retrobulbar Hyaluroni- Ocul Motil. 2020 Jul–Sep;70(3):71–78. dase in Reversing Filler-Induced Blind- Corvi F, Sadda SR, Staurenghi G, Epub 2020 May 28. ness: A Systematic Review. Ophthal- Pellegrini M. Thresholding strategies mic Plast Reconstr Surg. 2020 May/ to measure vessel density by opti- Schönbach EM, Strauss RW, Muñoz Jun;36(3):231–238. cal coherence tomography angiog- B, Wolfson Y, Ibrahim MA, Birch DG, raphy. Can J Ophthalmol. 2020 Aug; Zrenner E, Sunness JS, Ip MS, Sadda Shi Y, Marion KM, Jenkins D, Sadda 55(4):317–322. Epub 2020 May 18. SR, West SK, Scholl HPN; ProgStar S, Le PV, Chopra V. Identification and Study Group. Longitudinal Microperi- Characterization of Imaging Technique Saraswathy S, Bogarin T, Barron E, metric Changes of Macular Sensitivity Errors and Artifacts Using Anterior- Francis BA, Tan JCH, Weinreb RN, in Stargardt Disease After 12 Months: Segment OCT for Irido-Corneal Angle Huang AS. Segmental differences ProgStar Report No. 13. JAMA Ophthal- Evaluations in Glaucoma. Ophthalmol found in aqueous angiographic- mol. 2020 May 28;138(7):1–8. Glaucoma. 2019 May–Jun;2(3):136–144. determined high- and low-flow regions of human trabecular meshwork. Exp Asanad S, Fantini M, Sultan W, Nassisi June 2020 Eye Res. 2020 Jul;196:108064. Epub M, Felix CM, Wu J, Karanjia R, Ross- 2020 May 18. Cisneros FN, Sagare AP, Zlokovic Arnold AC. Aspirin Should Not Be BV, Chui HC, Pogoda JM, Arakaki X, Recommended to Prevent Second Curcio CA, McGwin G Jr, Sadda SR, Fonteh AN, Sadun AA, Harrington MG. Eye Involvement in Patients With Non Hu Z, Clark ME, Sloan KR, Swain T, Retinal nerve fiber layer thickness pre- arteritic Anterior Ischemic Optic Neu- Crosson JN, Owsley C. Functionally dicts CSF amyloid/tau before cogni- ropathy. J Neuroophthalmol. 2020 Jun; validated imaging endpoints in the tive decline. PLoS One. 2020 May 29; 40(2):271–273. Alabama study on early age-related 15(5):e0232785. eCollection 2020. macular degeneration 2 (ALSTAR2): Blankshain KD, Joslin CE, Pineles SL, design and methods. BMC Ophthalmol. Basilious A, Fung SSM, Ali A. Limbal Moss HE. Evolution of the Journal of 2020 May 19;20(1):196. Stem Cell Dysfunction in Ichthyosis Neuro-Ophthalmology and the Clinical Follicularis, Alopecia, and Photophobia Ophthalmology Literature: A 20-Year Sadda SR, Nittala Mphil MG, Syndrome. Cornea. 2020 May 29. Retrospective. J Neuroophthalmol. Taweebanjongsin W, Verma A, Velaga 2020 Jun;40(2):141–143. SB, Alagorie AR, Sears CM, Silva PS, Corradetti G, Corvi F, Nguyen TV, Aiello LP. Quantitative assessment Sadda SR. Management of Neovascu- Bonnet C, Miller KM. Safety and effi- of the severity of diabetic retinopa- lar Age-Related Macular Degeneration cacy of custom foldable silicone artifi- thy. Am J Ophthalmol. 2020 May 21: during the COVID-19 Pandemic. Oph- cial iris implantation: prospective com- S0002-9394(20)30251-8. thalmol Retina. 2020 Aug;4(8):757–759. passionate-use case series. J Cataract Epub 2020 May 29. Refract Surg. 2020 Jun;46(6):893–901. Pijpers IAB, Cao S, Llopis-Lorente A, Zhu J, Song S, Joosten RRM, Meng F, Friedrich H, Williams DS, Sánchez S, van Hest JCM, Abdelmohsen LKEA. Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis. Nano Lett. 2020 Jun 10;20(6):4472– 4480. Epub 2020 May 22.

Research and Funding | UCLA STEIN EYE INSTITUTE 97 Fan W, Uji A, Wang K, Falavarjani KG, Pashaei-Marandi A, Assam JH, Arnold Gupta K, Deng SX. Corneal Endo- Wykoff CC, Brown DM, Van Hemert A, Lee AG, Bonelli L. Can J Ophthal- thelial Decompensation. Klin Monbl J, Sagong M, Sadda SR, Ip M. Sever- mol. Reversible anisocoria due to Augenheilkd. 2020 Jun;237(6):745– ity of diabetic macular edema cor- inadvertent ocular exposure to topi- 753. Epub 2020 Jun 9. relates with retinal vascular bed area cal anticholinergic treatment for pri- on ultra-wide field fluorescein angi- mary axillary hyperhidrosis. 2019 Dec; Kieval JZ, Al-Hashimi S, Davidson RS, ography: DAVE Study. Retina. 2020 54(6):e300–e302. Epub 2019 Jun 4. Hamilton DR, Jackson MA, LaBorwit Jun;40(6):1029–1037. S, Patterson LE, Stonecipher KG, Segawa M, Wolf DM, Hultgren NW, Donaldson K, For the ASCRS Refrac- Hamedani AG, Pineles SL, Moss HE. Williams DS, van der Bliek AM, tive Cataract Surgery Subcommittee. The Case-Control Study in Neuro- Shackelford DB, Liesa M, Shirihai OS. Prevention and Management of Refrac- Ophthalmology. J Neuroophthalmol. Quantification of cristae architecture tive Prediction Errors Following Cata- 2020 Jun;40(2):144–147. reveals time-dependent characteristics ract Surgery. J Cataract Refract Surg. of individual mitochondria. Life Sci Alli- 2020 Jun 9. Tepelus TC, Song S, Borrelli E, ance. 2020 Jun 4;3(7):e201900620. Nittala MG, Baghdasaryan E, Sadda Lin SR, Ladas JG, Bahadur GG, SR, Chopra V. Quantitative Analy- Shen JF, Deng S, Hammersmith KM, Al-Hashimi S, Pineda R. A Review sis of Retinal and Choroidal Vascu- Kuo AN, Li JY, Weikert MP, Shtein RM. of Machine Learning Techniques for lar Parameters in Patients With Low Intraocular Lens Implantation in the Keratoconus Detection and Refractive Tension Glaucoma. J Glaucoma. 2019 Absence of Zonular Support: An Out- Surgery Screening. Semin Ophthalmol. Jun;28(6):557–562. comes and Safety Update: A Report 2019;34(4):317–326. Epub 2019 Jun 9. by the American Academy of Ophthal- Review. Boere PM, Bonnet C, Frausto RF, Fung mology. Ophthalmology. 2020 Jun 4; SSM, Aldave AJ. Multimodal Imaging S0161-6420(20)30232-3. Adachi K, Romero T, Nielsen-Saines K, of Pre-Descemet Corneal Dystrophy Pone S, Aibe M, Barroso de Aguiar E, Associated With X-Linked Ichthyosis Dow ER, Tsui I, Sarraf D. Macular Sim M, Brasil P, Zin A, Tsui I, Gaw SL, and Deletion of the STS Gene. Cornea. Infarction in a Patient with Sickle Cell Halai UA, Vasconcelos Z, Pereira JP, 2020 Jun 1. Trait. Retin Cases Brief Rep. 2020 Salles TS, Barbosa CN, Portari E, Jun 5. Cherry JD, Pone M, Moreira ME. Early Tsui E, Rao RC, Carey AR, Feng MT, Clinical Infancy Outcomes for Micro- Provencher LM. Using Social Media Asanad S, Frousiakis S, Wang MY, cephaly and/or Small for Gestational to Disseminate Ophthalmic Infor- Fantini M, Sultan W, Wood T, Nwako Age Zika-Exposed Infants. Clin Infect mation during the #COVID19 Pan- FU, Karanjia R, Sadun AA. Improving Dis. 2020 Jun 10;70(12):2663–2672. demic. Ophthalmology. 2020 Jun 2: the visual outcome in Leber’s heredi- S0161-6420(20)30514-5. tary optic neuropathy: Framework for Fung SSM, El Hamouly A, Sami H, the future. J Curr Ophthalmol. 2019 Jun Jiandani D, Williams S, Tehrani N, Xu X, Wang X, Sadda SR, Zhang Y. 6;31(3):251–253. eCollection 2019 Sep. Mireskandari K, Ali A. Corneal endo- Subtype-differentiated impacts of sub- thelium in paediatric patients with retinal drusenoid deposits on photo Fung SSM, Mason M, Gore DM, uveitis: a prospective longitudinal receptors revealed by adaptive optics Mireskandari K, Ali A. Technique for study. Br J Ophthalmol. 2020 Jun 10: scanning laser ophthalmoscopy. pediatric corneal crosslinking under bjophthalmol-2020-316120. Graefes Arch Clin Exp Ophthalmol. general anesthesia. J AAPOS. 2020 2020 Jun 2. Jun 6:S1091-8531(20)30104-X. McCannel CA, Mohney BG. 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98 UCLA STEIN EYE INSTITUTE | Research and Funding Tauber J, Ayoub S, Shah P, Wu M, Tsui Lee D, Chan CK, Abraham P, Sarraf D. Bonnet C, Ghaffari R, Alkadi T,Law E, Schuman JS, Rathi S. Assessing the Post-hoc analysis of single nucleotide SK, Caprioli J, Yu F, Deng SX. Long- Demand for Teleophthalmology in Flor- polymorphism profile for eyes with term outcomes of Descemet mem- ida Emergency Departments. Telemed vascularized pigment epithelial detach- brane endothelial keratoplasty in J E Health. 2020 Jun 12. ment due to ARMD. Eur J Ophthalmol. eyes with prior glaucoma surgery. 2020 Jun 24:1120672120932829. Am J Ophthalmol. 2020 Jun 30: Zhang Y, Wang X, Clark ME, Curcio CA, S0002-9394(20)30318-4. Owsley C. Imaging of age-related mac- Agrawal R, Testi I, Lee CS, Tsui E, ular degeneration by adaptive optics Blazes M, Thorne JE, Okada AA, Lee Lenis T, Zhang W, Shibayama V, scanning laser ophthalmoscopy in eyes Smith JR, McCluskey PJ, Kempen JH, Al-Hashimi S, Aldave AJ, Deng SX, with aged lenses or intraocular lenses. Tappeiner C, Agarwal M, Bodaghi B, Fung SSM. Multimodal Corneal Imag- Translational Vision Science & Technol- Nguyen QD, Gupta V, De Smet MD, ing of Genetically Confirmed Keratitis- ogy. June 12, 2020 Zierhut M, Pavesio C; COVID-19 IMT Ichthyosis-Deafness Syndrome. Study Group. Evolving consensus for Cornea. 2020 Jun 30. Shao J, Cao S, Williams DS, immunomodulatory therapy in non- Abdelmohsen LKEA, van Hest JCM. infectious uveitis during the COVID-19 Photoactivated Polymersome Nano- pandemic. Br J Ophthalmol. 2020 Jun motors: Traversing Biological Barriers. 25:bjophthalmol-2020-316776. Angew Chem Int Ed Engl. 2020 Jun 13. Alagorie AR, Nittala MG, Velaga S, Nittala MG, Uji A, Velaga SB, Akihito U, Zhou B, Rusakevich AM, Wykoff CC, Hariri AH, Naor J, Birch DG, Spencer Sadda SR. Association of Intravitreal R, Leng T, Capela A, Tsukamoto A, Ip Aflibercept With Optical Coherence MS, Sadda SR. Effect of Human Central Tomography Angiography Vessel Den- Nervous System Stem Cell Subretinal sity in Patients With Proliferative Dia- Transplantation on Progression of Geo- betic Retinopathy: A Secondary Analy- graphic Atrophy Secondary to Nonneo- sis of a Randomized Clinical Trial. JAMA vascular Age-Related Macular Degen- Ophthalmol. 2020 Jun 25:e202130. eration. Ophthalmol Retina. 2020 Jun 17 2020;S2468-6530(20)30241-4. Ridolfo R, Tavakoli S, Junnuthula V, Williams DS, Urtti A, van Hest JCM. Yan W, Peng YR, van Zyl T, Regev A, Exploring the Impact of Morphology Shekhar K, Juric D, Sanes JR. Cell Atlas on the Properties of Biodegradable of The Human Fovea and Peripheral Nanoparticles and Their Diffusion in Retina. Sci Rep. 2020 Jun 17;10(1):9802. Complex Biological Medium. Biomacro- molecules. 2020 Jun 26. Chanwimol K, Hirano T, Bedolla A, Tepelus T, Taweebanjongsin W, Marion Hou KK, Au A, Kashani AH, Freund KB, KM, Sadda S. Evaluation of Retinal Sadda SR, Sarraf D. Pseudoflow with Vessel Quantity within Individual Ret- OCT Angiography in Eyes with Hard inal Structural Layers Using Optical Exudates and Macular Drusen. Transl Coherence Tomography Angiography. Vis Sci Technol. 2019 Jun 27;8(3):50. Graefes Arch Clin Exp Ophthalmol. eCollection 2019 May. 2020 Jun 18. Rabiolo A, Caprioli J. Cataract Surgery Kothari N, Chu A, Huang JM, Lin F, Lin and Rate of Visual Field Progression BR, Manoharan N, Gui W, Huang AS, in Primary Open-Angle Glaucoma. Am Tsui I. Arm-mounted optical coherence J Ophthalmol. 2019 Aug;204:140–141. tomography angiography in extremely Epub 2019 Jun 27. low birth weight neonates with retinopathy of prematurity. Am J Ophthal- Hu, Z, Wang Z, Sadda S. Automated mol Case Rep. 2020 Jun;18:100624. Choroidal Segmentation in Spec- eCollection 2020 Jun. tral Optical Coherence Tomography Images with Geographic Atrophy Using Zamora-de La Cruz D, Zúñiga-Posselt Multimodal Complementary Infor- K, Bartlett J, Gutierrez M, Abariga SA. mation. J. of Medical Imaging, 6(2), Trifocal intraocular lenses versus bifo- 024009 (28 June 2019). cal intraocular lenses after cataract extraction among participants with Ahn J, Chiang J, Gorin MB. Novel presbyopia. Cochrane Database Syst mutation in SLC4A7 gene causing auto- Rev. 2020;6(6):CD012648. Published somal recessive progressive rod-cone 2020 Jun 18. dystrophy. Ophthalmic Genet. 2020 Aug;41(4):386–389. Epub 2020 Jun 29.

Research and Funding | UCLA STEIN EYE INSTITUTE 99 100 UCLA STEIN EYE INSTITUTE | Research and Funding About the Institute About the Institute

stablished in 1966, the UCLA Stein Eye Institute vision-science campus is the fulfillment of a dream—an ambitious plan developed byJules Stein, MD, to Eprevent blindness by transforming the quality of vision research, education, patient care, and community outreach. The Institute exists because of Dr. Stein, one of the most influential executives in entertainment who returned to his roots as a medical doctor to become a national advocate for vision science; and Bradley R. Straatsma, MD, JD, founding director of the Stein Eye Institute and founding chair of the UCLA Department of Ophthalmology, who created a bold plan for building the scope of ophthalmology in the UCLA School of Medicine. Together Drs. Stein and Straatsma ensured the Institute would take a central role in transforming vision science as a powerful platform for discovery and patient care to eradicate one of the great scourges of human existence: blindness. Under the leadership of Bartly J. Mondino, MD, director and chair since 1994, the Institute’s core pillars have been increasingly developed and a broad agenda of program-building and expansion has been implemented. The original dream for ophthalmology at UCLA has evolved into the Institute’s bold transformation to a vision-science campus—an interconnected community of facilities and people that merge research, training for new ophthalmologists, premier patient care, community outreach programs, and ongoing education for doctors worldwide. A historic partnership—a first of its kind—was forged with the Doheny Eye Institute in 2013, creating the nation’s preeminent organization for ophthalmic care and vision research under the banner of the UCLA Department of Ophthalmology. And today, patients across the Southland have access to the finest vision care at the Stein Eye Institute in Westwood; the UCLA Stein Eye Centers in Calabasas and Santa Monica; the Doheny Eye Centers UCLA in Arcadia, Orange County, and Pasadena; and UCLA-affiliated hospitals in Sylmar, Torrance, and West Los Angeles/Sepulveda. Since its opening on November 3, 1966, the Institute’s original mandate remains paramount: the relentless drive for excellence and the constant search for new pos- sibilities in the treatment of the eye. The Institute’s decades of accomplishments may have even exceeded the original soaring expectations of Dr. Stein who at the dedication ceremony defined his own prophecy for the Institute and the medical field he loved: “The men and women who will occupy this building and use its resources will share in future achievements that will outstrip any that have been seen; for science today is moving ahead with fantastic speed, and we must be sure that eye research moves with it. The history of this Institute begins with this dedication. I am confident that it will be a proud history.”

102 UCLA STEIN EYE INSTITUTE | About the Institute “If I am remembered for anything, it will not be for anything I did in show business, but for what I did to prevent blindness.”

DR. JULES STEIN

Doris and Jules Stein

The legacy of Dr. and Mrs. Jules Stein arises from their role in the 20th century as visionaries. Through brilliance and beneficence, they created a multi tude of programs aimed specifically at one goal: preserving and restoring eyesight. They approached this task dauntlessly, integrating the worlds of business, medicine, and philanthropy in such a way as to enhance each and leave in trust the promise of limitless accomplishment in the advancement of eye research and treatment. The Stein Eye Institute was established as a result of their philanthropy.

About the Institute | UCLA STEIN EYE INSTITUTE 103 Board of Trustees

The Board of Trustees, established in 1977, ensures the Institute’s orderly growth and development. The Board meets regularly during the year, with each trustee providing his/her unique counsel. Collectively, their invaluable contributions have included fiscal planning for the Institute, adoption of measures to facilitate recruitment of the world’s finest vision scientists, allocation of funds for the purchase of vision research equipment, and recommendations for expansion programs.

Norman Abrams, Esq. Charles T. Foscue Edward A. Landry, Esq. Distinguished Professor President and Partner of Law Emeritus Chief Executive Officer Musick, Peeler & Garrett Acting Chancellor Emeritus HAI Financial, Inc. 2016–2019 UCLA 2020–present 2015–present

Bartly J. Mondino, MD Ronald L. Olson, Esq. Gerald H. Oppenheimer Nelson C. Rising, Esq. Director Partner President Chair and Stein Eye Institute Munger, Tolles & Olson Gerald Oppenheimer Chief Executive Officer 1994–present 1995–present Family Foundation Rising Realty Partners President 2011–present Systems Design Associates 1992–present

Katrina vanden Heuvel Casey Wasserman Marissa Goldberg Publisher and Editor President and Chief Executive OBSERVER The Nation Officer Executive Director and 1984–present The Wasserman Foundation Chief Financial Officer 1998–present Doheny Eye Institute 2015–present

104 UCLA STEIN EYE INSTITUTE | About the Institute Executive Committee

The Executive Committee of the Stein Eye Institute and UCLA Department of Ophthalmology meets regularly during the year, with each member providing their unique expertise. The Committee ensures the orderly growth and development of the Institute and Department. It is involved in fiscal planning, expansion, recruitment, program development, and resolution of interdivisional issues.

Bartly J. Mondino, MD Director, Stein Eye Institute Chair, UCLA Department of Ophthalmology Affiliation Chair, Doheny Eye Institute

Anthony C. Arnold, MD Vice Chair, Education

Anne L. Coleman, MD, PhD Vice Chair of Academic Affairs, UCLA Department of Ophthalmology

SriniVas R. Sadda, MD President and Chief Scientific Officer, Doheny Eye Institute

Alfredo A. Sadun, MD, PhD Vice Chair, Doheny Eye Centers UCLA

Alapakkam P. Sampath, PhD Associate Director, Stein Eye Institute

Jonathan D. Smith Chief Administrative Officer, Stein Eye Institute

Gabriel H. Travis, MD Special Advisor

Mission Statement

The UCLA Stein Eye Institute is a vision-science campus dedicated to the preservation and restoration of vision through its global programs in innovative research, quality patient care, and multidisciplinary, integrative education, all with community outreach.

About the Institute | UCLA STEIN EYE INSTITUTE 105 Giving Opportunities

For more than half a century, UCLA’s vision scientists have extended the boundaries of current knowledge to reach the goal of a lifetime of good vision for everyone. This noble undertaking has been due in large part to a strong tradition of philanthropy from private sources. Contributions from individuals, foundations, and corporations help underwrite priority needs, which uphold scientific innovation, patient care, training and education, and a strong commitment to community engagement. The Institute offers a variety of giving options to those who wish to promote and participate in this tradition of excellence.

Ways to Give Securities Bequests Gifts of appreciated securities are tax Making a gift through your will or living Direct Gifts deductible at their full market value. In trust gives you the immediate satisfac- Direct gifts—whether by cash, check, most cases, appreciation in the value tion of creating a lasting and personal or credit card—are critically important of the security benefits the University legacy that ensures Stein Eye’s future to Stein Eye because the gifts can be and is not taxable to the donor. and costs nothing now. put to work immediately, increasing Matching Gifts Charitable Gift Annuity their impact and extending their reach. Many corporations have demonstrated In exchange for a gift of cash or appre- Endowments their support by matching or multiply- ciated securities, you can receive fixed A gift of an endowment demonstrates ing their employees’ gifts up to a set income for life and an immediate char- a long-term commitment, since the amount. Before making a gift, you may itable income tax deduction. In addi- fund is maintained in perpetuity. A por- want to ask whether your employer tion, a portion of the annuity payments tion of the annual investment income participates in a matching gift program. is tax-free. is used to support clinical, educa- Certain restrictions apply to matching Qualified Retirement Plans gifts. Please consult your company’s tional, and scientific initiatives and the Naming The UCLA Foundation as a personnel office. remaining investment yield is returned beneficiary of some or all of your quali- to principal, thus, over the years, the Real Estate fied retirement plan may help you min- fund can grow and provide continu- Real estate (your primary residence, imize taxes and maximize your philan- ous support. vacation home, commercial property, thropic impact, while leaving to your An endowment serves as an endur- or land) is an asset that you can lever- loved ones, assets that are less taxed. ing legacy as it can bear the donor’s age in a variety of ways to support the Tribute Gifts name or honor a loved one. Giving Institute while reducing taxes and elim- Contributions may be made in mem- opportunities exist for endowed chairs, inating the burden of maintaining or ory, honor, or celebration of a loved endowed fellowships, and endowed selling your property. You can also use one, or to commemorate a special funds for research, education, and real estate to fund gifts that provide occasion. Donations can be used for patient care. These funds can be made you with an income stream for life. payable for up to five years. unrestricted program support or be directed to any area of the Institute. Pledges A pledge is a formal statement of intention to make a gift. Donors who seek to defer the bulk of their giving Your Gift Can Make a Difference until a future date, or who want to give However you choose to support the Institute, you will be embarking on a partnership via installments over time, may use with one of the world’s preeminent eye research centers. Such an investment will this giving strategy. A pledge may be greatly expand our understanding of the causes of eye diseases, expose alternative followed by an immediate gift or may treatment options, and ultimately prevent blindness. simply confirm your intention to make a For information on how to incorporate the UCLA Stein Eye Institute into your gift in the future. Pledges are typically estate and retirement planning, or to make a gift of any kind, please contact: made in concert with a preliminary first installment and provide a source of Leiloni Breidert consistent and dependable funding. UCLA Stein Eye Institute Development Office This method often allows donors to 100 Stein Plaza, Room 1-124 give more generously than they may Los Angeles, California 90095-7000 have originally considered. Phone: (310) 206-6035 Fax: (310) 794-1665 [email protected]

106 UCLA STEIN EYE INSTITUTE | About the Institute

UCLA DEPARTMENT OF OPHTHALMOLOGY DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA