..CURRICULUM VITAE

______Signature Date Roy S. Chuck, M.D., Ph.D.

DEMOGRAPHIC INFORMATION

Appointments: Professor and University Chairman, Paul Henkind Chair, Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY [2009-present]

Director, Sissenwein Ophthalmic Research Laboratory, Albert Einstein College of Medicine, Bronx, NY [2009-present]

Professor, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY [2009-present]

Tom Clancy Professor, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD [2006-2009]

Director, Refractive Surgery Service, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD [2005-2009]

Associate Professor, Cornea and External Diseases and Refractive Surgery, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD [2004-2009]

Assistant Professor, Department of Biomedical Engineering, School of Engineering, University of California, Irvine. [2002-2004]

Assistant Clinical Professor, Southern California College of Optometry, Fullerton, California. [2002-2004]

Assistant Professor, Cornea and External Diseases and Refractive Surgery, Department of Ophthalmology, University of California, Irvine. [1999-2004]

Email: [email protected], [email protected]

Office: Montefiore Medical Center Department of Ophthalmology and Visual Sciences 111 East 210th Street Bronx, New York 10467-2490

1 (718) 920-6665 (718) 881-5439 Fax

Laboratory: 219 Ullmann Building Albert Einstein College of Medicine

Education and Training: 1986 University of California, Berkeley BS Engineering 1986-1993 Columbia University MD, PhD 1988-1989 Cornell University Medical College Visiting Scientist North Shore University Hospital 1989-1991 University of California, Berkeley Exchange Scholar Dept. of Molecular and Cell Biology 1988-1991 Columbia University Graduate Research Integrated Program in Cellular, Assistant Molecular and Biophysical Studies 1993-1994 St. Mary’s Health Center, St. Louis, MO PGY1, Intern in Internal Medicine 1994-1997 Washington University/Barnes Hospital PGY2-4, Resident in Ophthalmology 1997-1998 Washington University/Barnes Hospital Chief Resident in Ophthalmology 1998-1999 Doheny Eye Institute Cornea and Refractive University of Southern California Surgery Fellow, Instructor 1998-2000 Laboratory For Laser Research and Visiting Scientist Technology Development, Cedars Sinai Medical Center, Los Angeles, CA

RESEARCH ACTIVITIES

Publications:

Peer-reviewed scientific articles

1. Chuck RS, Oz MC, Delohery TD, Johnson JP, Bass LS, Nowygrod R and Treat MR. Dye-enhanced laser tissue welding. Lasers Surg Med 9:471-477, 1989.

2. Oz MC, Chuck RS, Johnson JP, Parangi S, Bass LS, Nowygrod R and Treat MR. Indocyanine green dye-enhanced welding with a diode laser. Surg Forum 40:316- 318, 1989. 3. Johnson JP, Oz MC, Chuck RS and Treat MR. Comparison of methods for transcatheter fragmentation of gallstones. Surg Endosc 3:7-10, 1989.

2 4. Popp HW, Oz MC, Bass LS, Chuck RS, Trokel SL and Treat MR. Welding of gallbladder tissue with a pulsed 2.15-micron thullium-holmium-chromium:YAG laser. Lasers Surg Med 9:155-159, 1989.

5. Johnson JP, Oz MC, Treat MR, Chuck RS and Trokel SL. Comparison of the thullium-holmium chromium:YAG laser to the ultrasonic lithotriptor and the electrohydraulic lithotriptor for the fragmentation of gallstones. Proc SPIE, 1989.

6. Oz MC, Bass LS, Popp HW, Chuck RS, Johnson JP, Trokel SL and Treat MR. In vitro comparison of the THC:YAG and argon ion lasers for gallbladder welding. Lasers Surg Med 9:248-253, 1989.

7. Chuck RS, Cantor CR and Tse DB. Dynamics of CD4-TCR complexes on human leukemic T cells. Proc Nat Acad Sci USA 87:5021-5025, 1990.

8. Oz MC, Johnson JP, Parangi S, Chuck RS, Marboe CC, Bass LS, Nowygrod R and Treat MR. Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser. J Vasc Surg 11:718-725, 1990.

9. Oz MC, Chuck RS, Johnson JP, Parangi S, Bass LS, Nowygrod R and Treat MR. Indocyanine green dye-enhanced vascular welding with the near infrared diode laser. Vasc Surg 24:564-570, 1990.

10. Oz MC, Bass LS, Chuck RS, Johnson JP, Nowygrod R and Treat MR. Strength of laser vascular fusion - preliminary observations on the role of thrombus. Lasers Surg Med 10:393-395, 1990.

11. Butenhoff TJ, Chuck RS, Limbach HH and Moore CB. The near-infrared photochemistry of porphine imbedded in an n-hexane matrix. Spectrochim Acta Part A-Molec Spectrosc 46:519-522, 1990.

12. Butenhoff TJ, Chuck RS, Limbach HH and Moore CB. Vibrational photochemistry of porphine imbedded in an n-hexane-d14 Shpol'skii matrix. J Phys Chem 94:7847-7851, 1990.

13. Libutti SK, Oz MC, Chuck RS, Nowygrod R and Treat MR. Dye-enhanced selective laser ablation of venous varicosities. Proc SPIE, 1990.

14. Libutti SK, Oz MC, Chuck RS, Treat MR and Nowygrod R. Dye-enhanced tissue welding using fibrinogen and continuous wave argon lasers. Vasc Surg 24:671- 676, 1991.

15. Libutti SK, Oz MC, Chuck RS, Auteri JS, Treat MR and Nowygrod R. A preliminary study of dye-enhanced laser photosclerosis. Surgery 109:163-168, 1991.

16. Libutti SK, Oz MC, Ashton RC, Chuck RS, Lontz JF, Treat MR, Lemole GM and Nowygrod R. Growth factor-enhanced laser tissue welding. Current Surg pp.449-451, September 1991.

3 17. Chuck RS, Cantor CR and Tse DB. Effect of CD4 engagement on CD4-T cell receptor complexes. Cellular Immunol 152:211-219, 1993.

18. Chuck RS, Williams JM, Goldberg MA and Lubniewski AJ. Recurrent corneal ulcerations associated with smokeable methamphetamine abuse. Am J Ophthalmol 121:571-572, 1996.

19. Chuck RS, Olk RJ, Weil GJ, Akduman L, Benenson IL, Smith ME and Kaplan HJ. Surgical removal of a subretinal cysticercus of Taeniaformis crassiceps. Arch Ophthalmol 115:562-563, 1997.

20. Lim-Bon-Siong R, Williams JM, Samapunphong S, Chuck RS and Pepose JS. Screening of myopic photorefractive keratectomy in eye bank eyes by computerized videokeratography. Arch Ophthalmol 116:617-623, 1998.

21. Vongthongsri A, Chuck RS and Pepose JS. Corneal iron deposits associated with LASIK. Am J Ophthalmol 127:85-86, 1999.

22. Quiros PA, Chuck RS, Smith RE, Irvine JA, Chao LC and McDonnell PJ. Infectious ulcerative keratitis after laser in situ keratomileusis. Arch Ophthalmol 117:1423-1427, 1999.

23. Chuck RS, Quiros PA, Perez AC and McDonnell PJ. Corneal sensation following laser in situ keratomileusis. J Cataract Refract Surg 26:337-339, 2000.

24. Read RW, Chuck RS, Rao NA and Smith RE. Traumatic Acremonium atrogriseum keratitis following laser-assisted in situ keratomileusis. Arch Ophthalmol 118:418-421, 2000.

25. Rao SN, Chuck RS, Chang AH, LaBree L and McDonnell PJ. The effect of age on the refractive outcome of myopic photorefractive keratectomy. J Cataract Refract Surg 26:543-546, 2000.

26. Fong YC, Chuck RS, Stark WA and McDonnell PJ. Phototherapeutic keratectomy for superficial corneal fibrosis after radial keratectomy. J Cataract Refract Surg 26:616-619, 2000.

27. Behrens A, Chuck RS and Bryant MR. Porcine eyes as an experimental model for wound healing. J Refract Surg 16:381, 2000.

28. Chuck RS, Behrens A and McDonnell PJ. Microkeratome-based limbal harvester for limbal stem cell transplantation: preliminary studies. Am J Ophthalmol 131:377-378, 2001.

29. Cohen D, Chuck RS, Bearman GH, McDonnell PJ and Grundfest WS. Ablation spectra of the human cornea. J Biomed Optics 6:339-343, 2001.

30. Chuck RS, Behrens A, Wellik SR, Liaw LH, Sweet PM, Osann KE, McDonnell PJ and Berns MW. Simple organ cornea culture model for re-epithelialization after in vitro excimer laser ablation. Lasers Surg Med 29:288-92, 2001.

4 31. Behrens A, Dolorico AMT, Kira DT, Novick LH, McDonnell PJ, Chao LC, Wellik SR and Chuck RS. Precision and accuracy of an artificial chamber system in obtaining corneal lenticules for lamellar keratoplasty. J Cataract Refract Surg 27:1679-87, 2001.

32. Chuck RS, Behrens A, Wellik S, Liaw LLH, Dolorico AMT, Sweet PM, Chao LC, Osann KE, McDonnell PJ and Berns MW. Re-epithelialization in cornea organ culture after chemical burns and excimer laser treatment. Arch Ophthalmol 119:1637-42, 2001.

33. Banik R, Novick LH, Smith RE and Chuck RS. Retrocorneal membrane with Descemet’s detachment. Cornea 20: 763-4, 2001.

34. Chuck RS, Arnoldussen ME, Cohen D, Behrens A, Bearman GH, McDonnell PJ and Grundfest WS. 193-nm excimer laser-induced fluorescence from cadaveric rabbit corneas. Rev Oftalmol Venez 57:2001.

35. Behrens A, Shah SB, Li L, Côté MA, Liaw LLH, Sweet PM, McDonnell PJ and Chuck RS. Evaluation of a microkeratome-based limbal harvester device for limbal stem cell transplantation. Cornea 21: 51-55, 2002.

36. Li L, Behrens A, Sweet PM, Osann KE, Chuck RS. Corneal lenticule harvest using a microkeratome and an artificial anterior chamber system at high intrachamber pressure. J Cataract Refract Surg 28: 860-865, 2002.

37. Li L, Ellis KR, Behrens A, Sweet PM and Chuck RS. A laboratory method for microkeratome-assisted posterior lamellar keratoplasty utilizing a running graft suture and a sutureless hinged flap. Cornea 21: 192-195, 2002.

38. Sarayba, MA, Li, L, Sweet PM and Chuck RS. A portable microkeratome-based anterior corneal surface harvesting device. Cornea 21: 589-591, 2002.

39. Chuck RS, Arnoldussen ME, Behrens A, Sweet PM, Cohen D, Bearman GH and Grundfest WS. Fluorescence-guided excimer laser removal of chemically damaged cornea. J Cataract Refract Surg 28:1847-1852, 2002.

40. Behrens A, Li L, Chuck RS. Obtaining lenticules for lamellar transplantation: Reply.J Cataract Refract Surg 29:6, 2003.

41. Wang Y, Nelson JS, Chen Z, Reiser BJ, Chuck RS, Windeler RS. Optimal wavelength for ultrahigh-resolution optical coherence tomography. Optics Express 11:1411-1417, 2003.

42. Tungsiripat T, Sarayba MA, Taban M, Sweet PM, Osann KE, Chuck RS. Viability of limbal epithelium after anterior lamellar harvesting using a microkeratome. Ophthalmology 111:469-75, 2004.

43. Sarayba M, Tungsiripat T, Sweet PM, Chuck RS. A portable microkeratome for harvesting the human anterior corneal surface. Cornea 23:443-6, 2004.

5 44. Memarzadeh F, Shamie N, Gaster RN, Chuck RS. Corneal and conjunctival toxicity from hydrogen peroxide. Ophthalmology 111:1546-9, 2004.

45. Memarzadeh F, Kandavel G, Chuck RS. Amniotic membrane transplantation for ocular surface disease. Contemp Ophthalmol 3:1-11 2004.

46. Erb MH, Taban M, Barsam CA, Sweet PM, Chuck RS. Mechanical stability of microkeratome-assisted intracorneal keratoprosthesis implantation. Arch Ophthalmol 122:1839-43, 2004.

47. Chuck RS, Shehada RE, McDonnell PJ, Grundfest WE. 193-nm excimer laser- induced fluorescence of flouroquinolones in rabbit corneas. Arch Ophthalmol 122:1693-1699, 2004.

48. Lane SS, Kuppermann BD, Fine IH, Hamill MB, Gordon JF, Chuck RS, Hoffman RS, Packer M, Koch DD. A prospective multicenter clinical trial to evaluate the safety and effectiveness of the implantable miniature telescope. Am J Ophthalmol 137:993-1001, 2004.

49. Wong EK, Kinyamu RD, Graff JM, Chak G, Wong MN, Agnic H, Kang E, Lin S, Vinita Jain V, Chuck RS. Development of a rat model for neurotrophic keratopathy. Exp Eye Res 79:297-303, 2004.

50. Sarayba M, Ignacio T, Sweet PM, Kurtz RM, Jurhaz T, Chuck RS. Femtosecond laser posterior lamellar keratoplasty: A laboratory model. Cornea 24:328-333, 2005.

51. Chuck RS, Graff J, Bryant MR, Sweet PM. Biomechanical characterization of human amniotic membrane preparations for ocular surface reconstruction. Ophthalmic Res 36:341-8, 2004.

52. Reiser BJ, Ignacio T, Wang Y, Taban M, Graff J, Sweet PM, Chen Z, Chuck RS. In vitro measurement of rabbit corneal epithelial thickness using ultrahigh resolution optical coherence tomography. Vet Ophthalmol 8:85-88, 2005.

53. Sarayba MA, Li L, Tungsiripat T, Liu NH, Sweet PM, Patel AJ, Osann KE, Chittiboyina A, Benson SC, Pershadsingh HA, Chuck RS. Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligand. Exp Eye Res 80:435-42, 2005.

54. Chang MA, Chuck RS. Total anterior corneal surface and epithelial stem cell harvesting: Current microkeratomes and beyond. Expert Rev Med Devices 1:251- 8, 2004.

55. Reyes JMG, Herretes S, Pirouzmanesh A, Wang D-A, Elisseeff JH, Jun AS, McDonnell PJ, Chuck RS, Behrens A. A modified chondroitin sulfate aldehyde adhesive for sealing corneal incisions. Invest Ophthalmol Vis Sci 46:1247-50, 2005.

6 56. Kandavel GR, Chuck RS. Staining properties of de-epithelialized human amniotic membrane. Cornea 24:853-6, 2005.

57. Vongthongstri A, Jakpaiwong W, Preechanon A, Lekhanont K, Chuck RS. Anterior vitreous tapping to prevent positive vitreous pressure during triple procedures. Ophthalmology 112:875-8, 2005.

58. Suwan-apichon O, Rizen M, Reyes JMG, Herretes S, Behrens A, Stark WJ, Chuck RS. A new donor cornea harvesting technique for posterior lamellar keratoplasty. Brit J Ophthalmol 89:1100-1, 2005.

59. Pirouzmanesh A, Herretes S, Reyes JM, Suwan-apichon O, Chuck RS, Wang DA, Elisseeff JH, Stark WJ, Behrens A.. Modified microkeratome-assisted posterior lamellar keratoplasty using a tissue adhesive. Arch Ophthalmol 124:210-4, 2006.

60. Sarayba MA, Kurtz RM, Nguyen TTB, Ignacio T, Mansoori M, Sweet PM, Chuck RS. Femtosecond laser-assisted intracorneal keratoprosthesis implantation: a laboratory model. Cornea 24:1010-14, 2005.

61. Ignacio TS, Nguyen TB, Chuck RS, Kurtz RM, Sarayba MA. Top hat wound configuration for penetrating keratoplasty using the femtosecond laser: A laboratory model. Cornea 25:336-40, 2006.

62. Ignacio TS, Nguyen TT, Sarayba MA, Sweet PM, Piovanetti O, Chuck RS, Behrens A. A technique to harvest Descemet's membrane with viable endothelial cells for selective transplantation. Am J Ophthalmol 139:325-30, 2005.

63. Suwan-apichon O, Reyes JMG, Herretes S, Vedula SS, Chuck RS. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Library issue 3, 2005.

64. Sikder S, Reyes JMG, Moon CS, Suwan-apichon O, Elisseeff JH, Chuck RS. Non invasive mitochondrial imaging in live cell culture. Photochem Photobiol 81:1569-71, 2005.

65. Suwan-apichon O, Rizen M, Rangsin R, Herretes S, Reyes JMG, Lekhanont K, Chuck RS. Botulinum B induced mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 47:133-9, 2006.

66. Reyes JMG, Fermanian S, Yang F, Zhou S-Y, Herretes S, Murphy DB, Elisseeff JH, Chuck RS. Metabolic changes in mesenchymal stem cells in osteogenic media measured by autofluorescence spectroscopy. Stem Cells 24:1213-7, 2006.

67. Suwan-Apichon O, Reyes JM, Griffin NB, Barker J, Gore P, Chuck RS. Microkeratome preparation of lamellar corneal grafts. Eye Contact Lens 32:248- 9, 2006.

68. Suwan-Apichon O, Reyes JM, Griffin NB, Barker J, Gore P, Chuck RS. Microkeratome versus femtosecond laser predissection of corneal grafts for anterior and posterior lamellar keratoplasty. Cornea 25:966-968, 2006.

7 69. Memarzadeh F, Shamie N, Fahd A, Chuck RS. Comparison of de-epithelialized amniotic membrane transplantation and conjunctival autograft after primary pterygium excision. Eye 22:107-12, 2008.

70. Park CY, Zhu Z, Zhang C, Moon CS, Chuck RS. Cellular redox state predicts in vitro corneal endothelial cell proliferation capacity. Exp Eye Res 83:903-10, 2006.

71. Lekhanont K, Leyngold IM, Suwan-apichon O, Rangsin R, Chuck RS. Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. Cornea 26:84-9, 2007.

72. Lekhanont K, Rojanaporn D, Chuck RS, Vongthongsri A. Prevalence of dry eye in an adult Thai population. Cornea 25:1162-7, 2006.

73. Lekhanont K, Park CY, Smith JA, Castro Combs J, Pisit Preechawat P, Suwan- apichon O, Rangsin R, Chuck RS. Effects of Topical Anti-inflammatory Agents in a Botulinum Toxin B Induced Mouse Model of Keratoconjunctivitis Sicca. J Ocular Pharm Ther 23:27-34, 2007.

74. Lekhanont K, Park CY, Combs JC, Suwan-apichon O, Rangsin R, Chuck RS. Effect of topical olopatadine and epinastine in the botulinum toxin b-induced mouse model of dry eye. J Ocular Pharm Ther 23:83-8, 2007.

75. Luanratanakorn P, Ratanapakorn T, Suwan-Apichon O, Chuck RS. Randomised controlled study of conjunctival autograft versus amniotic membrane graft in pterygium excision. Br J Ophthalmol. 90:1476-80, 2006.

76. Memarzadeh F, Chuck RS, McCulley TJ. Fornix reconstruction with conjunctival inclusion cyst marsupialization in Stevens-Johnson Syndrome. Ophthal Plast Reconstr Surg. 22:475-476, 2006.

77. Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Castillo JM, O'brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, Setten GV, Wilson SE, Yiu SC; and the Dysfunctional Tear Syndrome Study Group:. Dysfunctional Tear Syndrome: A Delphi approach to treatment recommendations. Cornea 25:900-907, 2006.

78. Kim A, Chuck RS. Preserved amniotic membrane transplantation for ocular surface reconstruction", US Ophthalmic Review 3:35-38, 206.

79. Noguera G, Lee WS, Castro-Combs J, Chuck RS, Soltz B, Soltz R, Behrens A. Novel laser-activated solder for sealing corneal wounds. Invest Ophthalmol Vis Sci. 48:1038-42, 2007.

80. Suh LH, Zhang C, Chuck RS, Stark WJ, Naylor S, Binley K, Chakravarti S, Jun AS. Cryopreservation and lentiviral-mediated genetic modification of human

8 primary cultured corneal endothelial cells. Invest Ophthalmol Vis Sci. 48:3056- 61, 2007.

81. Myrowitz E, Ren S, Chuck RS. Comparison of central corneal thickness measured by four different pachymeters. Eye Contact Lens 33:156-60, 2007.

82. Ramey N, Park CY, Gehlbach PL, Chuck RS. Imaging mitochondria in living corneal endothelial cells using autofluorescence microscopy. Photochem Photobiol. 83:1325-9, 2007.

83. Suwan-Apichon O, Reyes J, Herretes S, Vedula S, Chuck R. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Database Syst Rev. 4:CD005430, 2007.

84. Park CY, Zhuang W, Lekhanont K, Zhang C, Cano M, Lee WS, Gehlbach PL, Chuck RS. Lacrimal gland inflammatory cytokine gene expression in the botulinum toxin B-induced murine dry eye model. Mol Vis. 13:2222-32, 2007.

85. Park CY, Chuck RS, Cano M, Yew M, Nguyen V, Parker J, Mori K, Gehlbach PL. Periocular triamcinolone enhances intraocular gene expression after delivery by adenovirus. Invest Ophthalmol Vis Sci. 49:399-406, 2008.

86. Sirikul T, Prabriputaloong T, Smathivat A, Chuck RS, Vongthongsri A. Predisposing factors and etiologic diagnosis of ulcerative keratitis. Cornea. 27:283-287, 2008.

87. Cano M del V, Reyes JM, Park CY, Gao X, Mori K, Chuck RS, Gehlbach PL. Demonstration by Redox Fluorometry that Sulforaphane Protects Retinal Pigment Epithelial Cells against Oxidative Stress. Invest Ophthalmol Vis Sci. 49:2606-12, 2008.

88. Chuck RS. Refractive surgery and ectasia: what are we doing differently this year? Current Opin. Ophthalmol. 19:307-8, 2008.

89. Kim A, Chuck RS. Wavefront-guided customized corneal ablation. Curr Opin Ophthalmol. 19:314-20, 2008.

90. Park CY, Kohanim S, Zhu L, Gehlbach PL, Chuck RS. Immunosuppressive property of dried human amniotic membrane. Ophthalmic Res. 41:112-113, 2008.

91. Shin YJ, Nishi Y, Engler C, Kang J, Hashmi S, Jun AS, Gehlbach PL, Chuck RS. The effect of phacoemulsification energy on the redox state of cultured human corneal endothelial cells. Arch Ophthalmol. 127:435-41, 2009.

92. Zhu L, Shen J, Zhang C, Park CY, Kohanim S, Yew M, Parker JS, Chuck RS. Inflammatory cytokine expression on the ocular surface in the botulium toxin B induced murine dry eye model. Mol Vis. 15:250-8, 2009.

9 93. Park CY, Chuck RS. Sudden bilateral corneal edema in a patient with Parkinson’s disease. Acta Ophthalmologica 89:198-9, 2011.

94. Hongyok T, Chae J-M, Shin YJ, Na D, Li L, Chuck RS. Effect of chitosan-n- acetylcysteine conjugate in the botulinum toxin-B induced mouse model of dry eye. Arch Ophthalmol. 127:525-32, 2009.

95. Myrowitz E, Kurwa A, Parker JS, Chuck RS. Wavefront-guided photorefractive keratectomy after radial keratotomy, a descriptive series of consecutive cases. J Ref Surg. 25:470-2, 2009.

96. Freeman JC, Chuck RS. The next generation of refractive surgery patients. Curr Op Ophthalmol. 20:239-41, 2009.

97. Myrowitz E, Chuck RS. A comparison of wavefront-guided and wavefront- guided ablations. Curr Op Ophthalmol. 20:247-50, 2009.

98. Stasi K, Chuck RS. Update on phototherapeutic keratectomy. Curr Op Ophthalmol. 20:272-5, 2009.

99. Lee JK, Nkyekyer EW, Chuck RS. Microkeratome complications. Curr Op Ophthalmol. 20:260-3, 2009.

100. Nguyen VT, Hwang TN, Shamie N, Chuck RS, McCulley TJ. Amyloidosis-associated neurotrophic keratopathy precipitated by overcorrected blepharoptosis. Cornea. 28:575-6, 2009.

101. Kandavel GR, Kang JJ, Memarzadeh F, Chuck RS. Comparison of pterygium recurrence rates in Hispanic and Caucasian patients after primary excision and conjunctival autograft. Cornea. 29:141-5, 2010.

102. Hongyok T, Kim A, Ladas JG, Jun AS, Chuck RS. Phototherapeutic keratectomy with mitomycin C after Descemet’s stripping automated endothelial keratoplasty. Br J Ophthalmol. 94:377-8, 2010.

103. Shin YJ, Tata DB, Waynant RE, Gehlbach PL, Chuck RS. Fluorometric determination of the redox state and distribution of mitochondria in human malignant glioblastoma cells due to different culturing substrates. Photomed Laser Surg. Suppl 1:S105-10, 2010.

104. Lekhanont K, Choubtum L, Chuck RS, Sangiampornpanit T, Chuckpaiwong V, Vongthongsri A. A serum- and feeder-free technique of culturing human corneal epithelial stem cells on amniotic membrane. Mol Vis. 15:1294-302, 2009.

10 105. Park CY, Chuck RS. Severe epithelial keratopathy after hyperopic presbyopic photorefractive keratectomy. J Refract Surg. 25:483-4, 2009.

106. Park CY, Shin YJ, Lekhanont K, Zhang C, Lee WS, Cano M, Bucala R, Chuck RS. High expression of macrophage migration inhibitory factor in the murine lacrimal gland. Cornea. 29:187-91, 2010.

107. Park CY, Yang SH, Chuck RS, Gehlbach PL, Park CG. The role of indoleamine 2,3 dioxygenase in retinal pigment epithelial cell mediated immune modulation. Ocular Immunol Inflamm. 18:24-31, 2010.

108. Kuo IC, Myrowitz E, Chuck RS, Schein OD. Wavefront-guided photorefractive keratectomy to correct ametropia following aspheric ReSTOR implantation. J Refract Surg. 25:1111-5, 2009.

109. Bloom RI, Friedman IB, Chuck RS. Increasing rates of myopia: the long view. Curr Opin Ophthalmol. 21:247-8, 2010.

110. Pirouzian A, Ly H, Holz H, Sudesh RS, Chuck RS. Fibrin-glue assisted multilayered amniotic membrane transplantation in surgical management of pediatric corneal limbal dermoid: a novel approach. Graefes Arch Clin Exp Ophthalmol. 249:261-5, 2011.

111. Nishi Y, Engler C, Na DR, Kashiwabuchi RT, Shin YJ, Cano M, Jun AS, Chuck RS. Evaluation of phacoemulsification induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy. Acta Ophthalmologica Scandinavica. 88:323-7, 2010.

112. Zhou SY, Zhang C, Baradaran E, Chuck RS. Human corneal basal epithelial cells express an embryonic stem cell marker OCT4. Curr Eye Res. 35:978-85, 2010.

113. Park CY, Kim EJ, Choi JS, Chuck RS. Isolated Corneal Papilloma-like Lesion Associated With Human Papilloma Virus Type 6. Cornea. 30:600-3, 2011.

114. Park CY, Chuck RS. Residual refractive error and visual outcome after cataract surgery using spherical versus aspheric IOLs. Ophthalmic Surg Lasers Imaging. 1:1-7, 2010.

115. Oh SY, Choi JS, Kim EJ, Chuck RS, Park CY. The role of macrophage migration inhibitory factor in ocular surface disease pathogenesis after chemical burn in the murine eye. Mol Vis. 16:2402-11, 2010.

11

116. Victoria AC, Chuck RS, Rosenberg J, Schwarcz RM. Timing of eyelid surgery in the setting of refractive surgery: preoperative and postoperative considerations. Curr Opin Ophthalmol. 22:226-32, 2011.

117. Park CY, Chuck RS, Channa P, Lim CY, Ahn BJ. The effect of corneal anterior surface eccentricity on astigmatism after cataract surgery. Ophthalmic Surg Lasers Imaging. 30:1-9, 2011.

118. Park CY, Chuck RS. Reversible opacification of a hydrophilic acrylic intraocular lens. J Cataract Refract Surg. 38:166-9, 2012.

119. Park CY, Choi JS, Lee SJ, Hwang SW, Kim EJ, Chuck RS. Cyclooxygenase-2-expressing macrophages in human pterygium co-express vascular endothelial growth factor. Mol Vis. 17:3468-80, 2011.

120. Gehlbach PL, Chuck RS, Park CG, Park CY. Viral transgene expression delivered by repeat intraocular adenoviral vector injection: in vivo live imaging study. Mol Imaging. 11:361-371, 2012.

121. Park S, Fong AG, Cho H, Zhang C, Gritz DC, Mian G, Herzlich AA, Gore P, Morganti A, Chuck RS. Protocol for vital dye staining of corneal endothelial cells. Cornea. 31:1476-9, 2012.

122. Prince J, Chuck RS. Refractive surgery after Descemet's stripping endothelial keratoplasty. Curr Opin Ophthalmol. 23:242-5, 2012.

123. Park CY, Oh SY, Chuck RS. Measurement of angle kappa and centration in refractive surgery. Curr Opin Ophthalmol. 23:269-75, 2012.

124. Park CY, Chuck RS. Reply: Opacification of anterior part of hydrophilic acrylic IOL or a prelenticular inflammatory membrane? J Cataract Refract Surg. 38:1116, 2012.

125. Zhu L, Zhang C, Chuck RS. Topical steroid and non-steroidal anti- inflammatory drugs inhibit inflammatory cytokine expression on the ocular surface in a murine dry eye model. Mol Vis 18:1803-12, 2012.

126. Channa P, Chuck RS. The marriage of corneal graft and laser refractive surgery: something old and something new. Curr Opin Ophthalmol. 23:241, 2012.

127. Katz MS, Chuck RS, Gritz DC. Scleritis and episcleritis. Ophthalmology. 119:1715, 2012.

12 128. Chung SH, Choi SH, Choi JA, Chuck RS, Joo CK. Curcumin suppresses ovalbumin-induced allergic conjunctivitis. Mol Vis. 18:1966-72, 2012.

129. Park CY, Do JR, Chuck RS. Predicting postoperative astigmatism using Scheimpflug keratometry (Pentacam) and automated keratometry (IOLMaster). Curr Eye Res. 37:1091-8, 2012.

130. Yadav MK, Chuck RS, Park CY. Composition of artificial tear solution affects in vitro Pseudomonas aeruginosa biofilm formation on silicone hydrogel lens. J Ocul Pharmacol Ther. 29:591-4, 2013

131. Kim SH, Oh JH, Do JR, Chuck RS, Park CY. A comparison of anchored conjunctival rotation flap and conjunctival autograft techniques in pterygium surgery. Cornea. 32:1578-81, 2013.

132. Park CY, Chuck RS. Non-Descemet stripping Descemet membrane endothelial keratoplasty. Cornea. 32:1607-9, 2013.

133. Park CY, Do JR, Kim SH, Lim CY, Chuck RS. The effect of head tilt on keratometric measurement using the IOLMaster. Eye (Lond). 27:1411-7, 2013.

134. Nguyen MK, Chuck RS. Corneal collagen cross-linking in the stabilization of PRK, LASIK, thermal keratoplasty, and orthokeratology. Curr Opin Ophthalmol. 24:291-5, 2013.

135. Park S, Chuck RS. Corneal collagen cross-linking for correction of low myopia? Curr Opin Ophthalmol. 24:273-4, 2013.

136. Park CY, Oh JH, Chuck RS. Predicting ocular residual astigmatism using corneal and refractive parameters: a myopic eye study. Curr Eye Res. 38:851-61, 2013.

137. Oh JH, Kim SH, Chuck RS, Park CY. Evaluation of the Pentacam ray tracing method for the measurement of central corneal power after myopic photorefractive keratectomy. Cornea. 33:261-5, 2014.

138. Jing Y, Kumar PR, Zhu L, Edward DP, Tao S, Wang L, Chuck R, Zhang C. Novel Decorin mutation in a Chinese family with congenital stromal corneal dystrophy. Cornea. 33:288-93, 2014.

139. Oh JH, Chuck RS, Do JR, Park CY. Vitreous hyper-reflective dots in optical coherence tomography and cystoid macular edema after uneventful phacoemulsification surgery. PLoS 9: 2014.

13 140. Kuryan J, Cheema A, Chuck RS. Laser-assisted in situ keratomileusis (LASIK) versus laser-assisted subepithelial keratectomy (LASEK) for the correction of myopia. Cochrane Library (Issue 4, 2014).

141. Lee JK, Chuck RS. Changing trends in keratorefractive surgery. Curr Opin Ophthalmol 25:249-50, 2014.

142. Hyon JY, Shin YJ, Choi J, Kim DH, Chuck RS. Survival analysis of re- treatment after laser refractive corneal surgery in patients with myopia. J Ref Surg 30:1-2, 2014. 143. Chuck RS, Parikh NB. October consultation #3. J Cataract Refract Surg. 40:1748-9, 2014. 144. Lin B, Chen MZ, Fan S, Chuck RS, Zhou S. Effect of 0.025% FK-506 eyedrops on botulinum toxin B induced mouse dry eye. Invest Ophthalmol Vis Sci. 13-12925, 2014. 145. Do JR, Oh JH, Chuck RS, Park CY. Transient corneal edema is a predictive factor for pseudophakic cystoid macular edema after uncomplicated cataract surgery. Korean J Ophthalmol.29:14-22, 2015. 146. Chae JJ, Ambrose WM, Espinoza FA, Mulreany DG, Ng S, Takezawa T, Trexler MM, Schein OD, Chuck RS, Elisseeff JH. Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency. Acta Ophthalmol. 93:57-66, 2015. 147. Roh HC, Chuck RS, Lee JK, Park CY. The effect of corneal irregularity on astigmatism measurement by automated versus ray tracing keratometry. Medicine (Baltimore). 94(13), 2015. 148. Lee JK, Nguyen VQ, Chuck RS. Macroscopic and microscopic view of refractive surgery today. Curr Opin Ophthalmol. 26:241-2, 2015. 149. Lee JK, Chuck RS, Park CY. Femtosecond laser refractive surgery: small- incision lenticule extraction vs. femtosecond laser-assisted LASIK. Curr Opin Ophthalmol. 26:260-4, 2015. 150. Do JR, Oh JH, Chuck RS, Park CY. Author reply. Korean J Ophthalmol. 29:204-5, 2015. 151. Lim CY, Kim SH, Chuck RS, Lee JK, Park CY. Risk Factors for Pterygium in Korea: The Korean National Health and Nutrition Examination Survey V, 2010-2012. Medicine (Baltimore). 94(32), 2015. 152. Park CY, Lee JK, Chuck RS. Second harmonic generation imaging analysis of collagen arrangement in human cornea. Invest Ophthalmol Vis Sci. 56:5622-9, 2015. 153. Park CY, Lee JK, Gore PK, Lim CY, Chuck RS. Keratoplasty in the United States: A 10-Year Review from 2005 through 2014. Ophthalmology 1222432-42, 2015. 154. Park CY, Lee JK, Zhang C, Chuck RS. New details of the human corneal limbus revealed with second harmonic generation imaging. Invest. Ophthalmol. Vis. Sci. 56:6058-6066, 2015.

14 155. Roh HC, Lee JK, Kim M, Oh JH, Chang MW, Chuck RS, Park CY. Systemic comorbidities of dry eye syndrome: The Korean National Health and Nutrition Examination Survey V, 2010 to 2012. Cornea 35:187-92, 2016. 156. Park CY, Lee JK, Kahook MY, Schultz JS, Zhang C, Chuck RS. Revisiting ciliary muscle tendons and their connections with the trabecular meshwork by two photon excitation microscopic imaging. Invest. Ophthalmol. Vis. Sci. 57:1096-105, 2016. 157. Kwon JW, Cho KJ, Kim HK, Lee JK, Gore PK, McCartney MD, Chuck RS. Analyses of factors affecting endothelial cell density in an eye bank corneal donor database. Cornea. 35:1206-10, 2016. 158. Paley GL, Chuck RS, Tsai LM. Corneal-based surgical presbyopic therapies and their application in pseudophakic patients. J Ophthalmol. Mar 9, 2016 [Epub]. 159. Jung S, Kwon JW, Hwang HS, Chuck RS. Vascular regression after pinguecula excision and conjunctival autograft using fibrin glue. Eye Contact Lens. 43:199-202, 2017. 160. Jung S, Kwon T, Zhang CC, Chuck RS, Kwon JW. A novel surgical approach for oculodermal melanocytosis: superficial sclerectomy. Eye Contact Lens. 43:253-256, 2017. 161. Kwon JW, Rand GM, Cho KJ, Gore PK, McCartney MD, Chuck RS. Association between corneal endothelial cell density and topical glaucoma medication use in an eye bank donor population. Cornea 35:1206-10, 2016. 162. Park CY, Marando CM, Liao JA, Lee JK, Kwon J, Chuck RS. Details of the collagen and elastin architecture in the human limbal conjunctiva, Tenon's capsule and sclera revealed by two-photon excited fluorescence microscopy. Invest Ophthalmol Vis Sci. 57:5602-5610, 2016. 163. Park JH, Jeong H, Hong J, Chang M, Kim M, Chuck RS, Lee JK, Park CY. The effect of silica nanoparticles on human corneal epithelial cells. Sci Rep. 6:37762, 2016. 164. Chen Y, Tsao SW, Heo M, Gore PK, McCarthy MD, Chuck RS, Channa P. Age-stratified analysis of diabetes and pseudophakia effects on corneal endothelial cell density: A retrospective eye bank study. Cornea. 36:367-371, 2017. 165. Yim B, Park JH, Jeong H, Hong J, Shin YJ, Chuck RS, Park CY. The effects of nonporous silica nanoparticles on cultured human keratocytes. Invest Ophthalmol Vis Sci. 58:362-371, 2017. 166. Kuryan J, Cheema A, Chuck RS. Laser-assisted subepithelial keratectomy (LASEK) versus laser-assisted in-situ keratomileusis (LASIK) for correcting myopia. Cochrane Database Syst Rev. 2, 2017. 167. Marando CM, Park CY, Liao JA, Lee JK, Chuck RS. Revisiting the cornea and trabecular meshwork junction With 2-photon excitation fluorescence microscopy. Cornea. 36:704-711, 2017. 168. Jeong J, Song H, Lee JK, Chuck RS, Kwon JW. The effect of ocular biometric factors on the accuracy of various IOL power calculation formulas. BMC Ophthalmol. 17:62, 2017.

15 169. Kim DJ, Chuck RS, Lee JK, Park CY. Reversible opacification of hydrophobic acrylic intraocular lens- two cases report. BMC Ophthalmol. 17:111, 2017. 170. Juthani VV, Clearfield E, Chuck RS. Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery. Cochrane Database Syst Rev. 3, 2017. 171. Rand GM, Kwon JW, Gore PK, McCartney MD, Chuck RS. Technician consistency in specular microscopy measurements: A "real-world" retrospective analysis of a United States eye bank. Cornea. 36:1172-1177, 2017. 172. Saldanha IJ, Lindsley K, Do DV, Chuck RS, Meyerle C, Jones LS, Coleman AL, Jampel HD, Dickersin K, Virgili G. Comparison of clinical trial and systematic review outcomes for the 4 most prevalent eye diseases. JAMA Ophthalmol. 135:933-940, 2017. 173. Park JH, Kim JY, Kim DJ, Kim M, Chang M, Chuck RS, Park CY. Effect of nitric oxide on human corneal epithelial cell viability and corneal wound healing. Sci Rep. 7:8093, 2017. 174. Mayo-Wilson E, Ng SM, Chuck RS, Li T. The quality of systematic reviews about interventions for refractive error can be improved: a review of systematic reviews. BMC Ophthalmol. 17:164, 2017. 175. Park CY, Lee Jk, Chuck RS. Ultra-widefield imaging of spontaneously dislocated aphakic Soemmering ring. JAMA Ophthalmol. 2017 (in press)

Cornea Donor Study (Multi-investigator, UC Irvine PI):

1. Beck RW, Gal RL, Mannis MJ, Holland EJ, Cavanagh, HD, Foulks, GN, Heck EL, Lindquist T, Macsai MS, Smith RE, Stark WJ, Stulting RD, Sugar J. Is Donor Age an Important Determinant of Graft Survival? Cornea 18:503-510, 1999.

2. Cornea Donor Study Group. Baseline Donor Characteristics in the Cornea Donor Study (CDS). Cornea 24:389-396, 2005.

3. Cornea Donor Study Group. An Evaluation of Image Quality and Accuracy of Eye Bank Measurement of Donor Cornea Endothelial Cell Density in the Specular Microscopy Ancillary Study. Ophthalmology 112:431-440, 2005.

4. Cornea Donor Study Group. Clinical Profile and Early Surgical Complications in the Cornea Donor Study (CDS). Cornea 25:164-170, 2006.

5. Benetz, BA, Gal, RL, Ruedy KJ, Rice C, Beck RW, Lass, JL for the Cornea Donor Study Group. Specular Microscopy Reading Center Methods in the Specular Microscopy Ancillary Study (SMAS). Current Eye Research 31:319- 327, 2006.

6. Cornea Donor Study Investigator Group. The effect of donor age on corneal transplantation outcome: results of the cornea donor study. Ophthalmology 115:620-626, 2008.

16 7. Cornea Donor Study Investigator Group. Donor age and corneal endothelial cell loss five years after successful cornea transplantation: specular microscopy ancillary study results. Ophthalmology 115:627-632, 2008.

Non-peer reviewed articles

1. Chuck RS, Cohen D, McDonnell PJ, Grundfest WS. 193nm excimer laser-induced fluorescence spectroscopy during corneal ablative surgery. IEEE Lasers and Electro-Optics Society Annual Meeting, pp. 218-9, 1999.

Book Chapters

1. Chuck RS, Smith RE. Discussion of Hyperopic LASIK. Trans Am Ophthalmol Soc 1999.

2. Novick LH, Behrens A, Chao L, Chuck RS. VISX Star S2 excimer laser. Gimbel HV, Anderson Penno EE, editors. LASIK complications, Prevention and Management. 2nd Ed. Thorofare: SLACK Inc., p. 38-40, 2001.

3. Behrens A, Novick LH, Chao L, Chuck RS. Moria/Microtech Microkeratomes. Gimbel HV, Anderson Penno EE, editors. LASIK Complications, Prevention and Management. 2nd Ed. Thorofare: SLACK Inc., p. 28-31, 2001.

4. Shang B, Pirnazar JR, Chuck RS. The Economics of Refractive Surgery. Ophthalmic Hyperguide (on-line) Slack Publishing, Inc. 2001.

5. Ellis K, Pirnazar JR, Chuck RS. Corneal Topography. Ophthalmic Hyperguide (on-line) Slack Publishing, Inc. 2001.

6. Barsam CA, Chuck RS. Automated Lamellar Therapeutic Keratoplasty. Ophthalmic Hyperguide (on-line) Slack Publishing, Inc. 2003.

7. Sarayba MA, Kutzscher E, Chuck RS. Use of mechanical and femtosecond laser microkeratomes and an artificial anterior chamber for harvesting donor corneal lenticules. John T, editor. Surgical techniques in anterior and posterior lamellar corneal surgery. Slack Publishing, Inc. 2004.

8. Suh L, Chuck RS. Limbal Stem cell transplantation. Dunn JP, editor. AAO Manual (2009).

9. Chuck RS, Suwan-apichon O, Herretes S, Reyes JMG. Limbal stem cell transplantation. Agarwal A, Editor. Dry eye: a practical guide to ocular surface disorders. Slack Publishing, Inc., 2006.

10. Leyngold I, Chuck RS. Conjunctiva and tear film. Brightbill FS, McDonnell PJ, McGhee CNJ, Editors, Corneal Surgery, Theory, Technique and Tissue. 2009.

17 11. Kim A, Chuck RS. Microkeratome-assisted keratoprosthesis surgery. Agarwal A, Editor. Slack Publishing, Inc. 2009.

12. Cho H, Chuck RS. Pterygium excision and placement of amniotic membrane grafts. pp95-104. Hovanesian JA, Editor. Pterygium: techniques and technologies for surgical success. Slack Publishing, Inc. 2011.

13. Chuck RS, Herzlich AA, Niles P. The current status of corneal limbal stem cell transplantation in humans. Pp43-56. Tsang SH, Editor. Stem cell biology and regenerative medicine in ophthalmology.Humana Press (Springer).2013.

14. Huang S, Chuck RS, Lee JK. Limbal dermoids. Mastering Corneal Surgery. A. Agarwal, Editor. Slack Publishing, Inc. 2014.

Published Abstracts

1. Chuck RS, Cantor CR and Tse DB. CD4 and the T cell receptor: Molecular dynamics of association and dissociation. 7th International Congress of Immunology, Berlin, West Germany, August 1989.

2. Chuck RS, Cantor CR and Tse DB. Dynamics of CD4-T cell receptor complexes on human leukemic T cells. Mid-Winter Conference of Immunologists, Asilomar, CA, January 1990.

3. Wapner FJ, Eaton AM, Trokel SL, Schubert HD, Chuck RS and Treat MR. Dye- enhanced thermokeratoplasty. ARVO 1991 (Invest Opthalmol Vis Sci 32:S995, 1991).

4. Chuck RS, Fischer H and Ravi VN. Iontophoretic delivery of drugs to tumors: Analysis of behavior at the tumor margin. ARVO 1995. (Invest Ophthalmol Vis Sci 36:S500, 1995).

5. Williams JM, Chuck RS, Lim-Bon-Siong R and Pepose JS. Examination of corneal topographic characteristics of eye bank globes using a vertically mounted videokeratoscope: Emphasis on screening of post-refractive surgery corneas. EBAA 1995.

6. Chuck RS, Fischer H, Po S and Lim-Bon-Siong R. Optimization of dye-enhanced ab interno laser sclerostomy. ARVO 1996. (Invest Ophthalmol Vis Sci 37:S262, 1996).

7. Po S, Lim-Bon-Siong R, Fischer H and Chuck RS. Dye-targeted non-contact diode laser photothermal keratoplasty for correction of hyperopia. ARVO 1996. (Invest Ophthalmol Vis Sci 37:S570, 1996).

8. Bart DJ, Lim-Bon-Siong R, Lubniewski AJ and Chuck RS. Diode laser-activated biological glue for sealing corneal lacerations. ARVO 1996. (Invest Ophthalmol Vis Sci 37:S569, 1996).

18 9. Ravi VN and Chuck RS. Development of an injectable intraocular lens for preservation of accommodation. ARVO 1996. (Invest Ophthalmol Vis Sci 37:S770, 1996).

10. Williams JM, Chuck RS, Lim-Bon-Siong R and Pepose JS. Detection of PRK on cadaveric globes by videokeratography. ARVO 1996. (Invest Ophthalmol Vis Sci 37:S19, 1996).

11. Chuck RS, Olk RJ, Weil GJ, Benenson IL, Smith ME and Kaplan HJ. Surgical removal of a subretinal cysticercus of Taenia crassiceps. AAO 1996. (Video presentation).

12. Druger RK, Chuck RS, Wax MB, Kolker AE and Lubniewski AJ. Infectious crystalline keratopathy associated with trabeculectomy with mitomycin C. AAO 1996. (oral presentation)

13. Conners MS, Lubniewski AJ, Curtis RS and Chuck RS. Morphology of the corneal endothelium after combination seton/PKP surgery. ARVO 1998. (Invest Ophthalmol Vis Sci 39:S80, 1998).

14. Vongthongsri A, Chuck RS and Pepose JS. Corneal iron deposits associated with LASIK. ARVO 1998. (Invest Ophthalmol Vis Sci 39:S750, 1998).

15. Quiros PA, Chuck RS, Smith RE, Irvine JA and McDonnell PJ. Ulcerative keratitis associated with laser in situ keratomileusis. ISRS 1998.

16. Rao SN, Chuck RS, Chang AH, LaBree L and McDonnell PJ. The effect of age on the refractive outcome of myopic photorefractive keratectomy. ASCRS 1999.

17. Behrens A, Ellis K, Li L, McDonnell PJ, Chuck RS. Queratoplastia lamelar posterior como alternativa a queratoplastia penetrante para disfuncion endothelial. Resumen Congreso 2000.

18. Behrens A, Chuck RS, Shah SB, McDonnell PJ. Nuevo disector mecanico de celulas madre limbales basado en un microqueratomo manual. Resumen Congreso 2000.

19. Behrens A, Chuck RS, Kira DT, Dolorico AM, McDonnell PJ. Precision- exactitud de un sistema de camara artificial anterior para obtener lenticulos en queratoplastia lamelar. Resumen Congreso 2000.

20. Meallet M, Affeldt J, Roberts M, Appukuttan B, Read R, Reiser B, Chuck RS, Stout T and Rao N. Bleb disorder of the cornea. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S267, 2000).

21. Banik R, Novick LH and Chuck RS. Retrocorneal membrane with a large Descemet’s detachment. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S444, 2000).

19 22. McDonnell PJ, Chuck RS, Arnoldussen ME, Behrens A, Cohen D, Bearman GH and Grundfest WS. 193-nm excimer laser-induced fluorescence in fresh cadaveric rabbit and human eye bank corneas: Spectral component analyses. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S459, 2000).

23. Chuck RS, Arnoldussen ME, Behrens A, Liaw, L-H, Cohen D, Bearman GH, McDonnell PJ, Berns MW and Grundfest WS. Laser-induced fluorescence during 193-nm excimer laser ablation of rabbit cornea damaged by hydrochloric acid. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S459, 2000).

24. Arnoldussen ME, Chuck RS, Behrens A, Cohen D, Bearman GH, McDonnell PJ and Grundfest WS. 193-nm laser-induced fluorescence in diabetic human eye bank corneas. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S460, 2000).

25. Behrens A, Chuck RS, Wellik SR, Dolorico A, Chao LC, Abedi P and McDonnell PJ. Precision and accuracy of lamellar corneal disc dimensions obtained with an artificial anterior chamber and a manual microkeratome. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S530, 2000).

26. Wong CG, Dean N, Sioulis C, Kuppermann BD, Chuck RS, Grundfest WS, Ho M, Cohen D and Papaioannu T. Anti-sense oligonucleotides block angiogenesis in newly developed model of retinal neovascularization presenting with hemorrhage and subsequent fibrovascular membrane formation. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S641, 2000)

27. Liaw L-H, Chuck RS, Behrens A, Dolorico A, Wellik SR, Chao LC, McDonnell PJ and Berns MW. Re-epithelialization in a whole organ cornea culture model after acidic and basic chemical burns and subsequent treatment with excimer laser ablation. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S681, 2000).

28. Wellik SR, Chuck RS, Behrens A, Liaw L-H, Sun C-H, McDonnell PJ and Berns MW. Re-epithelialization in a whole organ rabbit cornea culture model after in vitro excimer laser ablation. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S682, 2000).

29. Novick LH, Behrens A, Chuck RS, Torres F, McDonnell PJ and Suarez E. Evaluation of LASIK outcomes in a Hispanic population. ARVO 2000. (Invest Ophthalmol Vis Sci 41:S686, 2000).

30. Behrens A, Chuck RS, Wellik SR, Dolorico A, Chao LC, Abedi P and McDonnell PJ. Precision and accuracy of an artificial anterior chamber system in obtaining corneal lenticules for lamellar keratoplasty. AAO 2000.

31. Shah SB, Behrens A, Li L, Sweet PM, McDonnell PJ and Chuck RS. A new large diameter microkeratome system for harvest of human limbal stem cell allografts. EBAA 2000.

20 32. Chuck RS, Li L, Behrens A, Sweet PM and McDonnell PJ. Harvesting corneal lenticules with a microkeratome and an artificial anterior chamber system. ARVO 2001. (Invest Ophthalmol Vis Sci 42:S26, 2001).

33. Li L, Behrens A, Sweet PM, Sanchez J, McDonnell PJ and Chuck RS. A laboratory model for microkeratome-assisted posterior lamellar keratoplasty utilizing a running graft suture and a sutureless hinged flap. ARVO 2001. (Invest Ophthalmol Vis Sci 42:S29, 2001).

34. Pirnazar JR, Shamie N, Behrens A, McDonnell PJ, Suarez E, Vongthongsri A and Chuck RS. Evaluation of LASIK outcomes in a Hispanic and Thai population. ARVO 2001. (Invest Ophthalmol Vis Sci 42:S489, 2001).

35. Ellis KR, Behrens A, Li L, Sweet PM, McDonnell PJ and Chuck RS. Posterior lamellar keratoplasty: Experimental approach to a new technique. ARVO 2001. (Invest Ophthalmol Vis Sci 42:S529, 2001).

36. Graff JM, Wong, Jr EK, Chuck RS, Wong M, Tran A, Lee C and McDonnell P. A ventral stereotactic approach for denervation of the sensory nerves to the cornea of the rat. ARVO 2001. (Invest Ophthalmol Vis Sci 42:S904, 2001).

37. Lin SS, Wong, Jr EK, Graff J, Chuck RS, Agnic H, Hoang N, Cho M, Hatch MS, Kostamaa H, McDonnell PJ. Neurotrophic keratitis: A rat model demonstrating a new observation in epithelial loss after lesion of V1. ARVO 2002 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2002.

38. Sarayba MA, Li L, Tungsiripat T, Liu NH, Sweet PM, Sanchez JA, Patel AJ, Osann KE, Pershadsingh HA, Chuck RS. Inhibition of corneal neovascularization by pioglitazone, a peroxisome proliferator-activated receptor-y ligand. ARVO 2002 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2002.

39. Tungsiripat T, Sarayba MA, Li L, Sweet PM, Chuck RS. A portable anterior corneal harvesting device. ARVO 2002 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2002.

40. Reiser BJ, Wang Y, Taban M, Graff J, Chen ZP, Chuck RS. A portable anterior cornea harvesting device. ASCRS 2003.

41. Shamie N, Taban M, Ohanessian R, Chuck RS. Keratopigmentation: a surgical technique with improved cosmetic results for the removal of limbal dermoids. ASCRS 2003.

42. Reiser BJ, Chuck RS. Detection of Fluoroquinolobe Antiobiotic Penetration in to Rabbit Cornea by Confocal Microscopy. ARVO 2003 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2003.

21 43. Baerveldt G, Chuck RS, See RF, Rao N, Gerg J, Schauer R. Novel glaucoma surgical treatment-Goniectomy with histology. ARVO 2003 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2003.

44. Chuck RS. Amniotic membrane transplant for ocular surface disorders”. American Society for Ophthalmic Registered Nurses, AAO 2003.

45. Chuck RS. Mechanical and laser microkeratome-assisted keratoprosthesis implantation”. Asia Pacific Academy of Ophthalmology [APAO] 2003.

46. Sarayba M, Almeda T, Nguyen BT, Mansouri M, Sweet PM, Kurtz RM, Chuck RS. Femtosecond laser-assisted posterior lamellar keratoplasty. Castroviejo Society – Eye Bank Association of America Federated Scientific Session 2003.

47. Memarzadeh F, Fahd A, Shamie N, Chuck RS. Comparison of de-epithelialized amniotic membrane transplantation and conjunctival autograft after primary pterygium excision in a Hispanic population. Castroviejo Society – Eye Bank Association of America Federated Scientific Session 2003.

48. Shamie N, Chuck RS, McCulley T. Systemic AL amyloidosis and bilateral neurotrophic keratopathy. AAO 2003.

49. Shamie N, Chuck RS, Kurtz R. Corneal sensation after LASIK flap creation by a femtosecond laser versus a microkeratome. AAO 2003.

50. Almeda TI, NguyenTT, Sarayba MA, Sweet PM, Chuck RS, Behrens A. A surgical technique to harvest Descemets membrane with viable endothelial cells for selective transplantation. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.

51. Sarayba MA, Juhasz T, Chuck RS, Almeda TI, Nguyen TT, Sweet PM, Kurtz RM. Femtosecond laser application in therapeutic keratoplasty. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.

52. King JA, Affeldt JC, Aldave AJ, Kutzscher E, Chuck RS. Spermatic corneal degeneration. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.

53. Chu CW, Wong EK, Brown D, Kenney MC, Kinyamu R, Chak G, Srour L, Punt N, Untalan P, Chuck RS. Changes in corneal RNA levels after denervation of the trigeminal nerve. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.Ophthalmology, Inc.: Rockville, MD, 2004.

54. Kandavel G, Chuck RS. Staining properties of de-epithelialized human amniotic membrane . ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.Ophthalmology, Inc.: Rockville, MD, 2004.

22

55. Memarzadeh F, Shamie N, Chuck RS, Erb MH, McCulley TJ. A novel surgical approach to fornix reconstruction in Stevens Johnsons Syndrome. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.Ophthalmology, Inc.: Rockville, MD, 2004.

56. Nguyen TT, Sarayba MA, Kurtz RM, Almeda TI, Sweet PM, Chuck RS. Intracorneal keratoprosthesis implantation using femtosecond laser: A laboratory model. ARVO 2004 [CD-ROM]; The Association for Research in Vision and Ophthalmology, Inc.: Rockville, MD, 2004.Ophthalmology, Inc.: Rockville, MD, 2004.

57. Nguyen TT, Sarayba MA, Almeda TI, Sweet PM, Chuck RS. Top hat femtosecond laser-assisted penetrating keratoplasty. ASCRS 2004.

58. Almeda TI, Sarayba MA, Nguyen TT, Sweet PM, Chuck RS. Femtosecond laser- assisted keratoprosthesis implantation: video presentation. ASCRS 2004.

59. Erb MH, Taban M, Barsam CA, Sweet PM, Chuck RS. Mechanical stability of microkeratome-assisted intracorneal keratoprosthesis implantation. ASCRS 2004.

60. Sarayba MA, Akmeda TI, Nguyen TT, Sweet RS, Chuck RS. Effect of corneal opacity on femtosecond laser microkeratome accuracy. ASCRS 2004.

61. Behrens A, Doyle J, Stern L, Chuck RS, McDonnell PJ and the Dysfunctional Tear Syndrome Group. Dysfunctional Tear Syndrome: A Delphi approach to treatment recommendations. AAO 2004.

62. Behrens A, Pirouzmanesh A, Ignacio T, Nguyen T, Chuck RS, McDonnell PJ. Dysfunctional Tear Syndrome therapy: A systematic review of the literature. AAO 2004.

63. Reyes JMG, Herretes S, Suwan-apichon O, Wang DA, Chuck RS, Behrens A, Ellisseeff JH. Chondroitin sulfate tissue adhesive for sealing corneal wounds. World Cornea Congress, 2005.

64. Suwan-apichon O, Reyes JMG, Herretes S, Chuck RS. Pterygium and tear function tests. World Cornea Congress, 2005.

65. Suwan-apichon O, Rizen M, Reyes JMG, Herretes S, Behrens A, Stark WJ, Chuck RS. A New Donor Cornea Harvesting Technique for Posterior Lamellar Keratoplasty. ARVO 2005.

66. Pirouzmanesh A, Herretes S, Reyes JMG, Suwan-Apichon O, Chuck RS, Wang DA, Elisseeff JH, Stark WJ, Behrens A. Modified Microkeratome-Assisted Posterior Lamellar Keratoplasty Using a Tissue Adhesive as Sealant. ARVO 2005 (and modified, PACO 2005).

67. Rizen M, Suwan-apichon O, Reyes JMG, Herretes S, Chuck RS. Botulinum toxin B induced mouse model of keratoconjunctivitis sicca. ARVO 2005.

23

68. Herretes SP, Suwan-apichon O, Reyes JMG, Pirouzmanesh A, Cano M, Yu Y, Gehlbach P, Chuck RS, Behrens A, Duh EJ. Pigment epithelium-derived factor inhibits bFGF-induced corneal neovascularization in mice. ARVO 2005.

69. Wang D, Reyes J, Herretes S, Pirouzmanesh A, Jun A, McDonnell P, Chuck R, Behrens A, Elisseeff J. Novel biological tissue adhesives for corneal surgery and repair. ARVO 2005.

70. Reyes JG, Herretes S, Pirouzmanesh A, Wang DA, Elisseeff J, Jun A, McDonnell PJ, Chuck RS, Behrens A. A modified chondroitin sulfate aldehyde adhesive for sealing corneal incisions. ARVO 2005.

71. Suwan-apichon O, Reyes JMG, Griffin NB, Barker J, Gore PN, Chuck RS. Microkeratome-assisted harvest and storage of posterior lamellar corneal allografts. AAO 2005.

72. Reyes JMG, Suwan-apichon O, Griffin NB, Barker J, Gore PN, Chuck RS. Microkeratome preparation of lamellar corneal grafts. Cornea Society 2005.

73. Lekhanont K, Leyngold IM, Suwan-apichon O, Rangsin R, Chuck RS. Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. ARVO 2006.

74. Kim A, Myrowitz EH, Stark WJ, Chuck RS. Appearance of Gas Bubbles in the Anterior Chamber After Femtosecond Laser Flap Creation. ARVO 20006.

75. Suh LH, Zhang C, Naylor S, Binley K, Behrens A, Chuck RS, Chakravarti S, Jun AS. Genetic modification of in vitro primary cultured human corneal endothelial cells with equine infectious anemia virus. ARVO 2006.

76. Cano MD, Reyes J, Chuck RS, Rosenzweig JM, Wu T, Mori K, Gao X, Talalay P, Gehlbach PL. Sulforaphane inhibits redox fluorometry shifts in retinal pigment epithelium cells following oxidative challenge. ARVO 20006.

77. Noguera GE, Lee W, Castro J, Soltz B, Soltz R, A.Kim1, Chuck RS, Behrens A. A Novel Photoactivated Biological Adhesive for Sealing Corneal Incisions.

78. Castro JM, Lee W, Noguera GE, Soltz B, Soltz R, Kim A, Chuck RS, Behrens A. A novel photoactivated biological tissue adhesive patch for sealing central corneal wounds. ARVO 2006.

79. Park CY, Lekhanont K, Lee WS, Chuck RS. Inflammatory cytokine gene expression of lacrimal gland of botulinum toxin-b induced mouse dry eye model. ARVO 2006.

80. Myrowitz E, Ren S, Chuck RS. Comparison of central corneal thickness measured by four different pachymeters. ARVO 2007.

24

81. Schmidt GW, Chuck RS. A novel suture-guided posterior lamellar keratoplasty technique for insertion of thin posterior lamellar grafts. ARVO 2007.

82. Zhuang W, Park CY, Cano M, Nguyen V, Mori K, Chuck RS, Gehlbach PL. Periocular triamcinolone increased vector traffic to liver following adenovirus mediated ocular gene delivery. ARVO 2007.

83. Kim A, Lopez MA, Rojas V, Broman AT, Chuck RS, Batlle JF. Comparison of preserved amniotic membrane and dehydrated amniotic membrane allografting using fibrin glue or sutures for attachment after excision of primary pterygium. ARVO 2007.

84. Zhu L, Park CY, Chuck RS. Immunosuppressive property of dried amniotic membrane. ARVO 2007.

85. Shin Y, Na D, Hongyok T, Cano M, Chuck R. Comparison of cellular redox state of endothelial cells from peripheral and central cornea. ARVO 2008.

86. Jun A, Speck CL, Stark WJ, Myrowitz EH, Braithwaite ML, Akpek EK, Behrens A, Chuck RS, Kim A, Chakravarti S. Establishment of a keratoconus research center at the Johns Hopkins Wilmer Eye Institute. ARVO 2008.

87. Hongyok T, Shin YJ, Cano M, Chuck RS. Strain-Related Response in the Botulinum Toxin-Induced Mouse Model of Dry Eye. ARVO 2008.

88. Kurwa A, Myrowitz E. Parker JS, Chuck RS. Visual outcomes in post-RK patients with Wavefront-guided PRK. AAO 2008.

89. Kim A, Hongyok T, Jun AS, Ladas JG, chuck RS. Phototherapeutic Keratectomy after Descemet-stripping automated endothelial keratoplasty for anterior corneal scarring. AAO 2008.

90. Nishi Y, Engler C, Na DR, Chae JM, Cano M, Jun AS, Chuck RS. The efficacy of redox fluorometry microscopy for evaluation of phacoemulsification-induced corneal endothelial damage and the protective effect of different solutions. ARVO 2009.

91. Chae JJ, Hongyok T, Shin YJ, Na D, Nishi Y, Chuck RS. Sex-related response in the botulinum toxin B-induced mouse model of dry eye. ARVO 2009.

92. Hongyok T, Hornof M, Chae JM, Shin YJ, Na D, Li L, Chuck RS. Thiolated chitosan for the treatment of dry eye - Evaluation in the botulinum toxin-B induced dry eye mouse model. ARVO 2009.

93. Cho H, Park S, Fong A, Gritz DC, Zhang C, Herzlich A, Mian G, Gore P, Morganti A, Chuck RS. Eye Bank Preparation, Injector Cartridge Pre-Loading,

25 Shipping and Cold Storage of DSAEK Grafts: A Laboratory Study of Endothelial Survival. ARVO 2011.

94. Park S, Fong AG, Cho H, Zhang C, Gritz DC, Mian G, Herzlich AA, Gore P, Morganti A, Chuck RS. Protocol for vital dye staining of corneal endothelial cells. ARVO 2011.

95. Fong AG, Cho H, Ali T, Reddy SC, Soltz B, Soltz R, Shrivastava A, Chuck RS. Novel laser-activated biological glue for sealing corneal wounds. ARVO 2011.

96. Herzlich AA, Prince–Wolfish J, Mozayan A, Zhang C, Jwo K, Gritz DC, Sprehe N, Gore P, ChuckRS. Eye bank preparation, injector cartridge preloading, shipping and cold storage of DSAEK grafts: A laboratory study of endothelial survival. ARVO 2012.

97. Chuck RS, Schachet J. Evaluating the efficacy of Systane Ultra post discontinuation of long-term use of Restasis (cyclosporine ophthalmic emulsion 0.05%). ARVO 2012.

98. Hu J, Chuck RS, Friedman A, Friedman J, Nacharaju P, Navati M, Yao W-J, Cheng C, Lee JK. A novel method of intraocular nitric oxide delivery. ARVO 2014.

99. Kurochkin P, Weiss R, Chuck RS, Fay J, Park CY; Lee JK. A novel method of intraocular lens power selection in cataract surgery using a Markov Chain Monte Carlo Simulator. Invest. Ophthalmol. Vis. Sci. 2015; 56:2977. ARVO 2015.

100. Rand G, Kwon JW PhD1,5, Kyong Cho J, Gore PK, McCartney MD, Chuck RS. The association between corneal endothelial cell density and topical glaucoma medication use in an eye bank donor population. Cornea Society/EBAA AAO 2015. 101. Park CY , Kim M , Lee JK , Chuck RS. Details of the collagen and elastin architecture in the human conjunctiva, Tenon's layer, and sclera revealed by two- photon excited fluorescence microscopy. ARVO 2016. 102. Rai D , Kwon JW , Cho KJ , Lee JK , Gore P , McCartney MD, Chuck RS. Effect of metformin on central corneal endothelial cell counts in banked eyes. ARVO 2016. 103. Kurochkin P, Qureshi S, Chuck RS, Lee JK. Effects of ferritin on the prevalence of cataracts. ARVO 2016. 104. Hu JY. Shrivastava A, Chuck RS, Kang J. A novel experimental model for the comparison of tensile suture strength of various ophthalmic sutures and knots. ARVO 2017. 105. Park JH, Kim DJ, Chuck RS, Park CY. The Effect of nitric oxide on human corneal epithelial wound healing. ARVO 2017.

26 106. Marando C, Park CY, Liao JA, Lee JK, Chuck RS. Revisiting the cornea and trabecular meshwork junction with two photon excitation fluorescence microscopy. ARVO 2017.

Cornea Donor Study (Multi-investigator, PI-University of California Irvine):

1. Ellis K, Gal R, Lester L, Moke P, Beck RW. A Web-Based Procedure for the Assignment of Donor Corneas in the Cornea Donor Study. Society of Clinical Trials Annual Meeting, 2001; Poster Presentation

2. Lass JH, Edwards SR, Beck RW, Gal RL, Ellis KJ, CDS Study Group. Quality Assessment and Cell Density Accuracy in the Cornea Donor Study: A Preliminary Analysis. EBAA Scientific Meeting, 2001; Podium Presentation

3. Mark J. Mannis, M.D. and the CDS Group: The Cornea Donor Study: Will it increase the supply of donor tissue? Cornea Society Meeting, October 2002; Podium Presentation

4. Jonathan H. Lass, MD, Shannon R. Edwards, Robin L. Gal, MSPH, Katrina J. Ruedy, MSPH, Mark J. Mannis, MD, Edward J. Holland, MD, Carmella L. Rice, and the CDS Group: Image Quality and Accuracy of Eye Bank Measurement of Donor Cornea Endothelial Cell Density in the Cornea Donor Study. ARVO Annual Meeting, April 2003; Poster Presentation

5. Jonathan H. Lass, MD and the CDS Group: Cornea Donor Study (CDS) Post- Enrollment Update. EBAA Annual Meeting, June 18-21; 2003; Podium Presentation

6. Lass JH, Gal RL, Benetz BA, Beck RW, Ruedy KJ, Mannis MJ, Holland EJ, Edwards SR, Rice C, Cornea Donor Study Group. Comparison of Eye Bank and Reading Center Central Endothelial Cell Density Measurements in the Cornea Donor Study (CDS). American Academy of Ophthalmology Combined Scientific Session, 2004; Poster Presentation

7. Benetz, BA, Gal, RL, Ruedy, KJ, Beck RW, Rice, C, Lass, JH for the Cornea Donor Study Group. Specular Microscopy Reading Center Methods in the Specular Microscopy Ancillary Study (SMAS). Ophthalmic Photographer’s Society Scientific Session, 2004; Podium Presentation

Doctoral Thesis

Characterization of a multimolecular assembly on the T-cell surface: The association of the T-cell antigen receptor with the CD4 molecule. (copyright 1992)

Inventions, Patents, Copyrights:

27 1989 Oz MC and Chuck RS. Laser tissue welding with dye-enhanced biologically compatible solders. (provisional).

1990 Libutti SK, Oz MC, Chuck RS and Bass LS. Dye-enhanced laser photosclerosis of venous varicosities and other vascular malformations. (provisional).

1997 Chuck RS, Cantor CR and Tse DB. Design and synthesis of bispecific DNA-antibody conjugates. (June 3, 1997; 5,635,602)

1998 Chuck RS, Cantor CR and Tse DB. Design and synthesis of bispecific reagents: use of double stranded DNAs as chemically and spatially defined cross-linkers. (December 15, 1998; 5,849,878)

2001 Chuck RS, Cohen D, Bearman GH, McDonnell PJ, Grundfest WS. Fluorescence-guided excimer laser ablation of corneal tissue. (provisional).

2004 Chuck RS. Devices and methods for harvesting limbal stem cells. (January 20, 2004; 6,679,898; addended and issued August 26, 2004)

2004 Chuck RS, Chou JS, Baerveldt G. Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration. (application 20040254438, December 16, 2004. Addended and issued 2016)

2004 Chuck RS. Methods and systems for identifying and isolating stem cells and for observing mitochondrial structure and distribution in living cells. (provisional/converted 2005. Issued July 6, 2010, 7,749,726)

2004 Chuck RS, Shehada RE, McDonnell PJ. System and method for quantitative and qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy. (application 20040199079, October 7, 2004. Issued February 26, 2008, 7,336,989)

2005 Baerveldt G, Chuck RS. Minimally invasive glaucoma surgical instrument and method. (originally issued December 27, 2005, 6,979,328. Broader claims issued August 31, 2010 7,785,321 B2).

2005 Chuck RS, Suwan-apichon O. Small animal model of dry eye for high throughput testing of therapeutics and drug absorption. (provisional)

2006 Chuck RS. Optimized topical drug formulation for the treatment of dry eye disease. (provisional)

2009 Chuck RS. Device for imaging at the ocular surface. (provisional)

28 2011 Chuck RS, Solz BA, Solz R. Methods and devices for crosslinking of corneal collagen and for treatment of disorders of the eye (#9445870, Issued September 20, 2016)

Extramural Research Sponsorship

1. Office of Naval Research Medical Free Electron Laser Program. Beckman Laser Institute Institutional Grant, Cornea Section. (Sub-investigator) 1999.

2. JAEB Center for Health Research. National Corneal Donor Eye Study. (UCI PI, 1%) August 1, 1999 through July 31, 2004. $1,750

3. Nidek, Inc. Excimer laser spectroscopy of the cornea: fluorescence-guided ablation of diseased cornea tissue. (PI, 5%) July 1, 2001-December 31, 2001. $21,287

4. Santen Inc. Evaluation of levofloxacin for infectious keratitis. (UCI PI, 1%) August 1, 2000 through August 31, 2005. $12,210

5. Kern County Research Foundation. A rat cornea model for angiogenesis. (PI, 5%) October 1, 2000 through June 30, 2001. $11,400

6. NIH/NEI - K08 EY00412-01A1. Laser spectroscopy of the cornea. (PI, 80%) May 1, 2001 through April 30, 2006. $929,652

7. UC Irvine College of Medicine Computer Desktop Initiative Grant For Laboratory Development. (PI, 1%) 2000. $2,500

8. UC Irvine College of Medicine Research Grant. Development of a whole organ rabbit cornea culture model to monitor healing after laser refractive surgery. (PI, 1%) 2000. $8,533.50

9. Health Sciences Partners Research Award. Fluorescence-guided excimer laser ablation of diseased corneal tissue. (PI, 1%) 2000. $7,500

10. Photogenesis, Inc. Amelioration of retinal diseases with a novel drug delivery system. (PI, 1%) 2000. $10,793

11. Allergan, Inc. Multi-center, double-masked, randomized, parallel-group study to compare the effectiveness and safety of restasis of Cyclosporine 0.05% ophthalmic emulsion vs. Refresh Plus used twice daily for up to 12-months in patients with moderate to severe keroratoconjunctivitis sicca. (UCI PI, 1%) June 2000-June 2001. $32,112

12. Allergan, Inc. Multi-center, randomized double-masked, vehicle controlled parallel group study evaluating the safety and analgesic efficacy of ketorolac tromethamine 0.4% ophthalmic solution in post photorefractive keratectomy patients. (UCI PI, 1%) November 2001-January 2002. $59,699

29 13. Allergan, Inc. A multicenter, double masked, randomized, vehicle controlled, parallel group study to compare the efficacy & safety of cyclosporine 0.05% ophthalmic emulsion used twice daily for six months in patients with moderate to severe keratoconjunctivitis sicca (KCS) (UCI sub-investigator) April 2002- October 2003. $45,918

14. LASIK Institute, Inc. LASIK-driven endothelial lamellar keratoplasty. (PI, 1%) April 12, 2001 through April 11, 2002. $9,380

15. LASIK Institute, Inc. procurement and eye bank storage of the anterior corneal surface for LASIK flap exchange. (PI, 1%) May 1, 2001 through April 30, 2002. $10,126

16. NIH UCI General Clinical Research Center. Automated microkeratome harvest of human limbal cornea for lamellar keratoplasty. (PI, 1%) January 1, 2002- December 31, 2002. $10,000.

17. Multi-investigator faculty research grant, UC Irvine. Femtosecond laser vitreous photodisruption. (Co-PI, 1%, with Peter J. McDonnell and Peter M. Rentzepis) (CORCLR) June 2002-June 2003. $10,000.

18. Intralase, Inc. Unrestricted gift to UCI. (PI) 2003. $65,000.

19. UCI Foundation Research Associates. Unrestricted gift. (PI) 2003. $5,000.

20. Allergan, Inc. A peptide antibiotic for corneal infection. (PI) 2003. $100,000.

21. Ista Pharmaceuticals, Inc. Bromfenac for post-cataract extraction inflammation. (UCI sub-investigator) 2003. $75,000.

22. Allergan, Inc. Unrestricted gift for dry eye research (PI) 2004. $1,000.

23. IOP, Inc. Unrestricted gift for ocular surface research (PI) 2004. $10,000.

24. Alpha Omega Alpha. Unrestricted gift for medical student research (Christina Moon, Dartmouth Medical College). $500.

25. Allergan, Inc. Unrestricted gift for dry eye research (PI) 2005. $10,000.

26. Alcon, Inc. Unrestricted gift for dry eye research (PI) 2005. $21,000.

27. VISX/AMO. Refractive surgery trials (PI) 2005-2006.

28. Chakshu, Inc. Phase I/II trial: topical inhibitor of cataract progression (PI) 2006. $95,000.

29. Allergan, Inc. Unrestricted gift for dry eye research (PI) 2006. $21,000.

30. Ista Pharmaceuticals, Inc. Unrestricted gift for clinical NSAID research (PI) 2006. $26,500.

31. Allergan, Inc. Unrestricted gift for dry eye research (PI) 2006. $17,000.

30

32. Medical Illness Counseling Center / Marriott Foundation. Unrestricted gift for mitochondria research (PI) 2006. $40,000.

33. IOP, Inc. Unrestricted gift for support of Wilmer education meetings (PI) 2007. $12,500.

34. Allergan, Inc. Horizon fellowship education award for support of refractive surgery education (PI) 2007. $20,000.

35. Allergan, Inc. Unrestricted gift for dry eye contact lens research (co-PI) 2007. $10,000.

36. Alcon, Inc. Unrestricted gift for dry eye testing research (co-PI) 2007. $10,000.

37. Alcon, Inc. Unrestricted gift for allergy research (co-PI) 2007. $38,000.

38. Alcon, Inc. Unrestricted gift for dry eye research (co-PI) 2007. $24,000.

39. Medical Illness Counseling Center / Marriott Foundation. Unrestricted gift for mitochondria research (PI) 2007. $40,000.

40. Chroma Pharma, Inc. Unrestricted gift for dry eye research (PI) 2008. $30,000.

41. Hess Foundation. Unrestricted gift [to Hopkins] for dry eye research (PI) 2007 $10K; 2008 $10K.

42. Lions Club International. Unrestricted department gift for glaucoma research and education (Chairman) 2009. $15,000.

43. NIHNEI- R44EY015955 Laser-activated ophthalmic adhesive. Conversion Energy Enterprises, Inc. Subcontract (PI, 10%) 2009-10. $150,000.

44. Hess Foundation. Unrestricted gift [to Einstein-Montefiore] for dry eye research (PI) 2009. $10,000.

45. Research to Prevent Blindness Foundation, unrestricted institutional grant (Chairman) 2011-2017. $115,000+ annually [2013-$250K].

46. Berger Family Trust, 4.5 million dollar gift and endowment (Chairman) 2010-11.

47. Joseph Alexander Foundation. Unrestricted department gift for optic nerve research (Chairman) 2009 $25K; 2010 $25K; 2011 $50K; 2012 $25K; 2014 $25K; 2015 $25K; 2016 $25K

48. Lewis Henkind unrestricted gift, 1 million dollar commitment (to be applied towards development of the Montefiore Center for Ophthalmic Innovation [COIN]), 2013.

31 49. Ronald Burde Fund for Resident Education, ongoing $500K+ alumni and friends fundraising effort to establish the Burde Residency Surgical Practice Laboratory [initiated 2013, currently at $500K]

50. Sissenwein Estate gift (Chairman), ~7-8 million dollar endowment. 2009 and 2016.

51. NIH R01 (co-PI [10%]; PI Suh). Enhancer-based senescence mechanism of glaucoma. (pending)

52. NIH SBIR (co-PI [15%]; PI O’Rourke [Microcures, Inc.]). A Novel therapeutic that harnesses microtubules to enhance corneal wound healing following an alkaline burn. (pending)

EDUCATIONAL ACTIVITIES

Teaching: Graduate Courses

July 2002 - 2004 Lecturer, BME 1: Introduction to Biomedical Engineering. The Henry Samueli School of Engineering, Department of Biomedical Engineering, UC Irvine.

July 2000- 2004 Lecturer and Clinical Preceptor, BME 240: Introduction to Clinical Medicine for Engineers. The Henry Samueli School of Engineering, Department of Biomedical Engineering, UC Irvine.

July 2000 - 2004 Clinical Preceptor, Cornea and Contact Lens Residency, Southern California College of Optometry.

July 1999 - 2004 Director and Preceptor, Cornea and Refractive Surgery Fellowship, Department of Ophthalmology, UC Irvine.

July 1999 - 2004 “Ophthalmic Physical Diagnosis for Medical Students II.” Department of Ophthalmology, UC Irvine.

July 1999 – 2004 Resident Clinic and Surgery Attending, Department of Ophthalmology, UC Irvine.

April2004-July 2009 Preceptor, Cornea and Refractive Surgery Fellowship, Wilmer Eye Institute, Johns Hopkins University.

April2004-July 2009 Preceptor, Medical Student Rotations, Wilmer Eye Institute, Johns Hopkins University.

Research Advisees:

32

Undergraduates: Jose Gonzalez (UC Riverside, 2000-2001), Matthew Nobe (UCLA, 2002-2003, 2005), Mona Mansouri (U. London, UK, 2003), Jack Parker (U. Alabama, 2006, 2007), Gibran Mian (Northwestern U., 2010-2012), Joseph Soucy (Rochester U., 2012). Medical students: Sarah Wellik (UCI, 1999-2000), Nancy Kim (UCI, 1999-2000), David Kira (U. Pittsburgh, 1999-2000), Paristou Abedi (UCI, 1999-2000), Melanie Ho (UCI, 2000-2001), Anup Patel (NY Medical College, 2001), Bibiana Reiser (USC, 2001-2002), Mehran Taban (UCI, 2001-2003), Jordan Graff (UCI, 2001- 2003), Shameema Sikder (U. of Arizona, 2005), Christina Moon (Dartmouth/Brown, 2005, 2007), Ilya Leyngold (Johns Hopkins, 2005), Nicholas Ramey (Johns Hopkins, 2005-2006), Margaret Yew (Johns Hopkins, 2006), Sahar Kohanim (Johns Hopkins, 2006), Matthew Nobe (UC Irvine, 2006, 2007), Joo Y. Cho (Dartmouth, 2007), Ambereen Kurwa (Georgetown, 2007), Joanne Kang (Columbia U., 2008), Sunju Park (Einstein, 2010-2011), Alan Fong (Einstein, 2009-2011); Jimmy Hu (Einstein, 2012-2013). Michael Tseng (Einstein, 2014-2017), Russell Levine (Einstein, 2014- 2015), Philip Kurochkin (Einstein, 2014-2017), Bella Wolf (Einstein, 2015-2018), Dinesh Patel (Einstein, 2015-2017), Gabriel Rand (Einstein, 2015-2016) Residents: Kenneth Ellis (UCI, 2000-2002), Barbara Shang (UCI, 2001-2002), Samir Shah (UCI, 2001-2002) , Rudrani Banik (UCI, 2001-2002), Melanie Erb (UCI 2001- 2004), Charles Barsam (UCI 2002-2003), Farnaz Memarzadeh (UCI 2003-2004), Ganesha Kandavel (UCI 2003-2004), Margaret Chang (Hopkins 2004), Michael Rizen (Hopkins 2004-2005), Leejee Suh (Hopkins 2004-2005), Greg Schmidt (Hopkins 2006- 2007), Shameema Sikder (Hopkins 2007-2008), Tofik Ali (Einstein 2009-2010), Hyung Cho (Einstein 2009-2011), Ana Carolina Victoria (Einstein 2009-2010), Alexandra Herzlich (Einstein 2009-2012), Jessica Prince (Einstein 2011-2014), Sunju Park (Einstein 2012-2015), Michelle Nguyen (Einstein 2012-2015), Jonathan Fay (2014- 2017), Jimmy Hu (2016-2018), Isaac Chocron (2017-2018), Gabriel Rand (2017- present) Laboratory Post-doctoral Fellows: Ashley Behrens (Venezuela, 1999-2001), Li Li (China, 2000-2001), Melvin Sarayba (Philippines, 2002-2004), Tulaya Tungsiripat (Thailand, 2001-2002), Tes Almeda-Ignacio (Philippines, 2003-2004), Bibiana Reiser (UCI, 2002-2003), Thao Nguyen (U. of Laval, Ontario, Canada, 2003-2004), Samantha Herretes (Venezuela, 2004-2005), Johann M. G. Reyes (Philippines, 2004- 2005), Olan Suwan-apichon (Thailand, 2004-2005), Shi-You Zhou (China, 2005- 2006), Kaevelin Lekhanont (Thailand, 2005-2006), Choul-Yong Park (South Korea, 2005-2007), Zeijin Zhu (China/Doheny, 2005), Woo-Seok Lee (South Korea, 2005- 2006), Zhu Lei (China, 2006-7), Wenjuan Zhuang (China, 2006-7), Teravee Hongyok (Thailand, 2007-2008), Young Shin (South Korea, 2007-2008), Dae Ro Na (South Korea, 2007-2008), Jeremy Chae (South Korea, 2008-2010), Yutaro Nishi (Japan, 2008-2009), So-Hyang Chung (South Korea, 2010-2012), Choul Yong Park (visiting professor, 2014-2015, Ji-won Kwon (visiting professor, 2015-2016), Yang Jing (USA 2016-present) UCI Clinical Fellows: Lee Novick (Tulane U., 1999-2000), Jonathan R. Pirnazar (Washington U., 2000-2001), Norman Liu (USC, 2000-2001), Matthew Kaufman

33 (Baylor U., 2001-2002), Neda Shamie (UCI, 2002-2003), Ethan Kutzscher (Cal Pacific Medical Center, 2003-2004). Wilmer Eye Institute Clinical Cornea Fellows: 2004-5: Richard Adler, Timothy Blake, Paul Botelho, Clement Cheng, Alisa Kim. 2005-6: Julie Gutmark, Linda Rose, Melvin Wagner, Sheel Patel, Vasudha Panday. 2006-7: Jung Lee, Bairn (Mike) Walker, Laura Green, Samir Shah, Ava Huchun. 2007-8: Jimmy Lee, Philip Stanley, Sachin Kalyani, Neel Desai, Melanie Bennett- Simms, Gregory Schmidt. 2008-9: Lamees Ashker, Stacy Bang, Erica Edell, Kalliopi Stasi, Bradford Tannen.

Editorial Activities: Editorial Board Member: Lasers in Surgery and Medicine (ASLMS) [2005-present] Editorial Board Member: Current Opinion in Ophthalmology [2008-present] Editorial Board Member: BMC Ophthalmology [2015-present] Refractive Surgery Editor: Current Opinion in Ophthalmology [2008-2015] Editorial Board Member: Journal of Refractive Surgery (ISRS/AAO) [2005-2012] Guest Editor: PPAR Research, special issue on PPARs and RXRs in Eye Biology and Disease [2008] Refractive Surgery Editor: eOphthalmology Review [2008] Editorial Board Member: Cochrane Eyes and Vision Group (Cochrane Library) [2013-present] Editor (single issue): “Advances and future prospects in refractive cataract surgery”. Journal of Ophthalmology [2016] Cataract and Refractive Surgery Editor: BMC Ophthalmology (2016-present) Steering Committee: Cochrane Eyes and Vision US Project (CEV@US) (2016- present) AAO Preferred Practice Pattern Committee: Refractive error and management. Member 2005-present (Chair 2015-present). Steering Committee: AAO Preferred Practice Pattern (2015-present).

Journal Peer Review: Current Opinion in Ophthalmology New England Journal of Medicine IEEE Transactions in Biomedical Engineering Journal of Biomedical Optics Journal of Clinical Virology Archives of Ophthalmology American Journal of Ophthalmology Cornea Journal of Cataract and Refractive Surgery Ophthalmology Guest Editorial Board Member, Investigative Ophthalmology and Visual Sciences Journal of Refractive Surgery Transactions of the American Ophthalmology Society Lasers in Surgery and Medicine

34 Investigative Ophthalmology and Visual Sciences

CLINICAL ACTIVITIES

Certification: Licensure State of New York #253154-1 State of Maryland #D0061169 [expired] State of California #G084571 [expired] State of Missouri [expired] Board Certification, American Board of Ophthalmology (Diplomate, 1999; re- certification 2010-2020)

ORGANIZATIONAL ACTIVITIES

Institutional Administrative Appointments:

2009-present Chairman, Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center 2016 Diversity and Inclusion Committee, Albert Einstein College of Medicine 2015-2016 Member, Steering Committee for new Einstein 2015-2017 Member, Einstein Committee on Patents 2015- Co-chair, Committee on Admissions, Albert Einstein College of Medicine. 2011-present Member, Board of Directors, Montefiore IPA 2009-present Member, Finance Committee, Montefiore IPA 2011-2012 Member, Montefiore Internet Steering Committee 2010-2011 Member, Montefiore Accountable Care Organization, Clinical/Network Operations Committee 2010-2016 Member, Montefiore Medical Executive Committee 2010-2016 Member, Montefiore North Division Council 2010-2011 Member, Montefiore Medical Center Culture and Inclusion Committee [Chair, language subcommittee] 2010-2016 Member, Medical Advisory Board, The Eye Bank For Sight Restoration, Inc., NY, NY 2009-present Member Academic Senate, Albert Einstein College of Medicine 2014-6 Member, Academic Senate Council, Einstein [8 elected member Dean’s Advisory] 2012 Chair, search committee for Chair of Urology, Albert Einstein College of Medicine and Montefiore Medical Center. 2011 Member, search committee for Chair of Pediatrics and Director Childrens Hospital, Albert Einstein College of Medicine and Montefiore Medical Center.

35 2008-9 Medical School Council, Johns Hopkins Hospital 2007-8 Wilmer Retreat Planning Committee 2007-8 Wilmer Biostatistics Committee 2006 Wilmer Physician Compensation Group 2006-7 Wilmer 2010 Committee 2006 Johns Hopkins Medicine Leadership Development Program 2006-8 Co-Director, Friday Afternoon Research Meeting (FARM) Committee 2006-9 Member, Associate Professor Promotion Committee 2006-9 Member, Wilmer Research Meeting Committee 2005-9 Member, Wilmer Long Range Planning Committee 2005-9 Member, Wilmer Finance Committee 2005-9 Member, Wilmer Annual Research Meeting Planning Committee 2005-9 Program Director, Wilmer Resident Association Annual Meetings 2005-9 Member, Johns Hopkins Green Spring Station Board of Governors 2005-9 Director of Refractive Surgery 2005-9 Co-medical Director Wilmer at Greenspring Station 2004 Member, Department of Ophthalmology Search Committee for Cornea faculty position. 2002-2003 Chair, Department of Ophthalmology Search Committee for Low Vision faculty position. 2002 Interviewer, College of Medicine Search Committee for Dermatology Chair. 2002 Member, Department of Ophthalmology Search Committee for research faculty. 2001 Member, Department of Ophthalmology Search Committee for Oculoplastics faculty position 2001 Chair, Department of Ophthalmology search committee for Optometry and Cornea faculty positions. 2000-2002 University of California, Irvine, College of Medicine Representative Assembly. 1999 University of California, Irvine. COM Health Sciences Strategic Planning Retreat IV 1999-2004 University of California, Irvine. College of Medicine Institutional Review Board (3-year term, renewed 2002). 1999-2004 University of California Irvine, Department of Ophthalmology, Cornea and Refractive Surgery Fellowship Director. 1999-2004 Residency Education Committee 1999-2004 Residency Selection Committee 1999-2002 Department of Ophthalmology Strategic Planning Retreat. 1986 Engineering Science Steering Committee, College of Engineering, UC Berkeley [committee to develop bioengineering curriculum]

Professional Societies:

Local: Orange County Ophthalmology Society (1999-2004)

36 Maryland Academy of Ophthalmology (2008) Bronx Lions Club (2009-present) New York Keratorefractive Society (2009-2012) New York Intraocular Lens Society (2009-2012) Ophthalmic Laser Society (2009. 2014-present) Manhattan Ophthalmological Society (2009-present) New York Clinical Ophthalmology Society (2010-present) New York State Ophthalmological Society (2010-present) Westchester Ophthalmological Society (2011-present)

National: Castroviejo Cornea Society (2002-present) Paton Society (Eye Bank Association of America) (2002-present) Tear Film and Ocular Surface Society (2002-present) Chinese American Ophthalmological Society (2002-lifetime) [elected Secretary/Treasurer 2004-6, President 2006-8] American Academy of Ophthalmology (AAO) (1994-present) American Medical Association (AMA) (1986-1993) American Society for Lasers in Medicine and Surgery (ASLMS) (1987-1993, 2001) Association for Research in Vision and Ophthalmology (ARVO) (1994-present) Society of the Engineering Sciences (SES) (1982-1986) Tau Beta Pi National Engineering Society (1985-lifetime) Alpha Omega Alpha National Medical Honor Society (1998- lifetime) American Society for Laser Medicine and Surgery (2003-present)

International: International Society for Optical Engineering (SPIE) (1987-1993) International Society of Refractive Surgery (ISRS) (2004-present)

Conference Session Chair:

Sept. 2003 Bioinformatics, Gene Arrays and Proteomics, Western Eye Research Conference, Laguna Beach, CA. Nov. 2003 Dry Eye Treatment and Diagnosis: A New Understanding, American Academy of Ophthalmology, Anaheim, CA. June 2004 Afro-Asian Congress of Ophthalmology: Cornea Section, Istanbul, Turkey. Oct. 2004 Treatment Recommendations for the Dysfunctional Tear Syndrome (Dry Eye): A Consensus Opinion From a Panel of Experts. American Academy of Ophthalmology, New Orleans, LA. Sept. 2005 Development of artificial corneas and retinas. ARVO Western Eye Research Conference, Laguna Beach, CA.

37 Oct. 2005-6 Moderator, Cornea Free Paper Session. American Academy of Ophthalmology, Chicago, IL; Las Vegas, NV. Dec. 2005-9 Chair, Refractive Surgery Session, Current Concepts in Ophthalmology, Baltimore, MD. Feb/Mar. Chair, Refractive Surgery Session, Current Concepts in 2006-9 Ophthalmology, Dorado, PR; Vail, CO, MD. 2006-9 Director/organizer, Annual Wilmer Residents Association Meeting Nov. 2007 Chair, Enhancing treatment in long-term management of dry eye, AAO, New Orleans, LA Nov. 2008 Chair, Optimizing treatment for dry eye, AAO, Atlanta, GA Sept. 2011 Honorary VP, 4th Global Chinese Ophthalmology Congress, Guangzhou, China. April 2012 Chair, Refractive Surgery Session. Asia Pacific Academy of Ophthalmology. Busan, S. Korea. November 2017 Chair, Refractive Correction Preferred Practice Pattern Symposium, American Academy of Ophthalmology. New Orleans, LA. January 2018 Chair, Cornea session, Current Concepts in Ophthalmology (NYU). Atlantic City, NJ.

Review Groups:

July 2003 National Institutes of Health, National Eye Institute, Center for Scientific Review Special Emphasis Panel, “Keratoplasty Applications”. Nov. 2003 National Institutes of Health, National Eye Institute, Center for Scientific Review Special Emphasis Panel, VISA Study Section, “Anterior Eye Diseases” Aug. 2005-6 Chair, Tissue Banks International Advisory Committee on Specialty Allografts 2006-present American Academy of Ophthalmology Refractive Errors and Treatment Preferred Practice Patterns (PPP) panel [Chair 2015- ] 2010 Research to Prevent Blindness scientific review panel 2013-present Fight For Sight scientific review panel 2013-present Chair, AAO Industry training committee 2013 Research to Prevent Blindness Special Advisory Board [9 member group of department chairs] 2014-2016 American Society of Cataract and Refractive Surgery annual meeting, scientific poster judge [Boston, MA; San Diego, CA; New Orleans, LA]

Consultantships:

2014-present Consultant TecLens [surgical] 2014-2017 Consultant Shire [pharmaceutical]

38 2016-present Consultant Novartis [pharmaceutical] 2008 Consultant Aton Pharma [pharmaceutical] 2007-2009 Medical Advisory Board, Arsenal Biomedical [surgical] 2007 Consultant, Vistakon [pharmaceutical] 2006 Consultant, Bausch and Lomb [pharmaceutical] 2005-2012 Consultant, Alcon Inc., Ft. Worth, TX. [pharmaceutical] 2005-2007 Speakers Bureau and consultant, Ista Pharmaceuticals, Inc., Irvine, CA. [pharmaceutical] 2003-2006 Speakers Bureau and consultant, Allergan Inc., Irvine, CA. [pharmaceutical] 2002-2004 Consultant, Neomedix, Inc., San Juan Capistrano, CA. [development of UC-owned IP] 2002-2004 Consultant, Tekia, Inc., Irvine, CA. [development of UC-owned IP] 2002-2016 Consultant, IOP-Katena, Inc., Costa Mesa, CA. [surgical] 2001-2003 Speakers Bureau, Santen, Inc., Napa, CA. [pharmaceutical] 2001 Consultant, Nidek, Inc., Pasadena, CA. [surgical] 2001 Ophthalmology consultant, California Police Officers Safety Training Manual. 2000-2002 Consultant, MTL, Inc., La Mirada, CA. [surgical]

RECOGNITION

Awards, honors

California Honor Society Golden Seal Bearer (1982-lifetime) Academic Achievement Scholar for the City of Berkeley, CA (1982) American Savings and Loan Mathematics Scholar (1982) Home Savings of America Collegiate Business Scholar (1982-1986) University of California at Berkeley Chancellor's Scholar (1982-1986) University of California at Berkeley Dean's List (1982-1986) Tau Beta Pi National Engineering Honor Society (1985-lifetime) ARCS Foundation/Lawrence Berkeley Laboratory Collegiate Research Fellow (1984-1986) NIH Medical Scientist Training Program (MSTP) (1986-1993) Alpha Omega Alpha (1994-present) Rosenbaum Research Award (1996) Heed Ophthalmic Foundation Fellowship (1998) National Eye Institute ARVO Travel Grant (2000) UC Irvine College of Medicine Research Award (2000) Health Sciences Partners Research Award (2000) UCI College of Medicine Outstanding Clinician-Scientist Award (2003) American Academy of Ophthalmology Achievement Award (2005) Lions Club International, Melvin Jones Fellow/Humanitarian Award (2010) Chinese Ophthalmological Society, honorary annual meeting Vice President (2011)

39 NYC Chinatown Honor Award for Community Service (2015) Fight For Sight Foundation Physician-Scientist honoree [co-honorees Nancy Kerrigan, Bebe Neuwirth] (2017)

Invited talks

Oct. 1999 “Surgical reconstruction of the ocular surface.” Southern California College of Optometry, Fullerton, CA Nov. 1999 “Laser spectroscopy of the cornea.” IEEE/LEOS, San Francisco, CA Jan. 2000 “Ocular surface reconstruction.” Ophthalmology Grand Rounds. Long Beach Memorial Medical Center, Long Beach, CA Feb. 2000 “Ocular surface reconstruction.” Visiting Professor, Grand Rounds, Department of Ophthalmology, Loma Linda University June 2000 “New techniques for ocular surface reconstruction.” Doheny Days Research Conference, Doheny Eye Institute, University of Southern CA July 2000 “Cataracts, dry eyes and other vision problems in the elderly.” Irvine Senior Center Nov. 2000 “Cataracts, dry eyes and other vision problems in the elderly.” Orange Senior Center Nov. 2000 “New developments in complex corneal transplantation.” Monarch Health Care Ophthalmology Update Dec. 2000 “New developments in ocular surface reconstruction.” UC Irvine Ophthalmology Grand Rounds Feb. 2001 “Ocular surface reconstruction: historical perspective & future predictions.” Research Study Club Midwinter Conference, University City, CA Apr. 2001 “Thermokeratoplasty: collagen contraction in ophthalmology.” American Society for Laser Medicine and Surgery, Inc. Workshop, New Orleans, LA May 2001 “Classification of limbal stem cell deficiency.” Management of Ocular Surface Disorders Workshop, Los Angeles, CA Aug. 2001 “Advances in corneal transplantation.” Orange County Optometric Society Annual Ocular Pathology Conference, Southern California College of Optometry, Fullerton, CA August 2001- “Advances and controversies in ocular fluoroquinolone therapy”, 2002 International Center for Post-graduate Medical Education (CME), San Diego, CA; Universal City, CA; Troy, MI; Napa, CA; Downey, CA; Williamstown, MA; Denver, CO; Dallas, TX; Memphis, TN; Los Angeles, CA; Costa Mesa, CA; San Francisco, CA; Dana Point, CA, Portland, OR Sept. 2001 “The Application of LASIK techniques to corneal transplantation”, Harvard University, The Massachusetts General Hospital/Wellman Labs, Photomedicine and Photobiology Seminar Series, Boston, MA. (re-scheduled due to national disaster)

40 Oct. 2001 “Microsurgery course instructor”, Alcon Surgical, Inc., Irvine, CA Nov 2001-4 “Phacoemulsification course instructor”, American Academy of Ophthalmology, New Orleans, LA Nov 2001 “Microkeratome-assisted limbal stem cell transplantation”, ALTK Symposium, American Academy of Ophthalmology, New Orleans, LA Nov. 2001 “Update on corneal research at UC Irvine”, Department of Ophthalmology Grand Rounds, Irvine, CA Nov. 2001 “The next generation of ocular fluoroquinolone therapy- controversies in treatment”, Stanford Peninsula Ophthalmologic Society meeting, Palo Alto, CA Feb. 2002 “Advances in Corneal Transplantation and Research”, “The Eternal Flame of Life”, Lifesharing Community Organ and Tissue Donation, California Center for the Arts, Escondido, CA Feb. 2002 “Controversies in treatment of bacterial keratitis”, Phoenix Ophthalmological Society meeting, Phoenix, AZ Feb 2002 “The Application of LASIK techniques to the treatment of corneal disease”, Harvard University, The Massachusetts General Hospital/Wellman Labs, Photomedicine and Photobiology Lecture Series, Boston, MA Feb. 2002 “The next generation of ocular fluoroquinolone therapy- controversies in treatment”, Volusia County/Daytona Beach Ophthalmologic Society meeting, Ormond Beach, FL Mar. 2002 “The next generation of ocular fluoroquinolone therapy- controversies in treatment”, Tucson Ophthalmologic Society meeting, Tucson, AZ May 2002 “The next generation of ocular fluoroquinolone therapy- controversies in treatment”, Hawaii Ophthalmologic Society meeting, Honolulu, HI May 2002 Judge, Twenty-third annual student research symposium, Southern California College of Optometry, Fullerton, CA Sept. 2003 Session Chair, Bioinformatics, Gene Arrays and Proteomics, Western Eye Research Conference, Laguna Beach, CA Apr. 2003- “Anti-infectives for modern cataract and LASIK surgery” and 2006 “New treatments for dry eye”. Access Communications (CME), Newport Beach, CA; El Segundo, CA; San Diego, CA: Pasadena, CA; Loma Linda, CA; San Francisco, CA; Riverside, CA; Palm Springs, CA; Sacramento, CA; Cerritos, CA; Temecula, CA; Indian Wells, CA; Hollywood,CA; Fresno, CA Mar. 2003 “Amniotic membrane grafts for pterygium surgery”. Annual Post- graduate Convention, Loma Linda University, Loma Linda, CA May 2003 “Topical cyclosporine A treatment of inflammatory dry eye”. Research Day, Department of Ophthalmology, Loma Linda University, Loma Linda , CA

41 May 2003 “The Application of LASIK techniques to corneal transplantation”. Visiting Professor Rounds, Cal Pacific Medical Center, San Francisco, CA July 2003 “New techniques in ocular surface reconstruction”. Visiting Professor Rounds, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland Nov. 2003 “Pathways for advancement for young clinician-scientists”. Annual meeting American Chinese Medical Association, Jules Stein Eye Institute, University of California, Los Angeles Nov. 2003 “Amniotic membrane transplant for ocular surface disorders”. American Society for Ophthalmic Registered Nurses, American Academy of Ophthalmology, Anaheim, CA Dec. 2003 “Mechanical and laser microkeratome-assisted keratoprosthesis implantation”. Asia Pacific Academy of Ophthalmology, Bangkok, Thailand Feb. 2004 “Advances in pterygium surgery” and “IOL calculations after refractive surgery”. Ocular Drug and Surgical Therapy Update, Dana Point, CA May 2004 “Microkeratome-assisted keratoprosthesis implantation” and “Amniotic membrane for pterygium surgery”. Wilmer Resident Association and Wilmer Nursing Association Meetings, Baltimore, MD June 2004 “Microkeratome-assisted keratoprosthesis implantation” and “Amniotic membrane for pterygium surgery”. Afro-Asian Congress of Ophthalmology Annual Meeting, Istanbul, Turkey Dec. 2004 “Limbal stem cell transplantation: Present and future”, and “Femtosecond laser posterior lamellar keratoplasty”. Current Concepts in Ophthalmology Meeting, Baltimore, MD Jan. 2005 “Amniotic membrane transplantation”, SUNY Annual Ophthalmology Update, Brooklyn, NY April 2005 Ocular surface reconstruction. Visiting Professor, U. of Louisville, KY May 2005 NSAIDS for ocular surgery. Academy of Managed Care Pharmacy Meeting, Dever, CO Amniotic membrane grafting for pterygium surgery. Wilmer Resident Association Meeting, Baltimore, MD Advances in corneal surgery, Annual Kaiser Ophthalmology Meeting, Anaheim, CA Sept 2005-06 Teleconference on New Advances in Topical NSAIDS [Bromfenac] New Advances in Topical NSAIDS [Napafanec] Greensboro, NC, Columbia, SC, Falls Church, VA, York, PA, Philadelphia, PA. New Advances in Topical NSAIDS [Bromfenac]. Philadelphia, PA, Maui, Hawaii Oct. 2005 “Update on ocular stem cell research at the Wilmer Eye Institute.” Wilmer Advisory Committee Meeting

42 Dec. 2005 “Advances in refractive keratoplasty”. Current Concepts in Ophthalmology, Baltimore, MD Jan. 2006 “Update on corneal epithelial stem cell transplantation”, Institute for Cell Engineering and Neuroscience Seminar, JHU Feb/Mar. 2006 Femtosecond laser-assisted keratoplasty; Advances in pterygium surgery; Laboratory animal testing of dry eye therapeutics. Current Concepts in Ophthalmology, Dorado, PR and Vail, CO Oct. 2006 Femtosecond laser keratoplasty. Visiting Professor, University of California San Francisco Dec. 2006 LASIK update. Current Concepts in Ophthalmology, Baltimore, MD Jan. 2007 Pterygium surgery and eye banking updates. Hawaiian Eye Meeting, Kauai, HI Feb/Mar. 2007 LASIK, Pterygium and eye banking updates. Current Concepts in Ophthalmology, Montego Bay, Jamaica and Vail, CO Apr. 2007 Femtosecond laser keratoplasty. National cornea and anterior segment symposium [optometry continuing education], Baltimore MD June 2007 Femtosecond laser LASIK update. Air Force Annual Ophthalmology Symposium, San Francisco, CA August 2007 Update on current research on dry eye disease. Chicago, IL Sept. 2007 LASIK, Pterygium and keratoplasty updates. St. Luke’s Inaugural International Ophthalmology Symposium, Manila, Philipines Oct. 2007 Ocular surface reconstruction, University of California San Francisco Nov. 2007 Dry eye update, AAO Late Breakers Session (invited), AAO, New Orleans, LA Dec. 2007 Refractive surgery and cornea updates. Wilmer Current Concepts in Ophthalmology, Baltimore, MD; Carribean, and Vail, CO. Dec. 2007 Refractive surgery and dry eye updates, Al Tawam Hospital, Al Ain, Abu Dhabi, UAE Jan. 2008 Femtosecond laser keratoplasty, and Ocular surface reconstruction: Visiting Professor, University of Pennsylvania and Scheie Eye Institute, Philadelphia, PA Feb. 2008 Clinical cornea update, Alcon Continuing Physician Education for residents. Ft. Worth, TX May 2008 Ocular Surgery News and Italian Society of Ophthalmology, Naples, Italy May 2008 Visiting Professor, Boston University, Boston, MA. June 2008 Refractive Surgery. World Congress of Ophthalmology, Hong Kong, China June 2008 Femtosecond laser-assisted keratoplasty. Presidential Visiting Professor, Sun Yat-sen Eye Center, Guangzhou University, China. June 2008 Femtosecond laser-assisted keratoplasty, and Trabecular removal (Trabectome) surgery. Visiting Professor, Beijing Eye Center, China

43 June 2008 Femtosecond laser-assisted keratoplasty. Visiting Professor, Henan Eye Institute, China August 2008 Visiting Professor, Albert Einstein College of Medicine, Bronx, NY Sept. 2008 Refractive surgery and DSEK. Fuchs Dystrophy Symposium, Tissue Banks International. Baltimore, MD Oct. 2008 Femtosecond laser keratoplasty, and Ocular surface reconstruction: Fall Update Meeting, Visiting Professor and Distinguished Alumnus Lecture, Washington University, St. Louis, MO Oct. 2008 Cornea update. Visiting Professor and plenary speaker, Indiana University Eye Center 100th Anniversary and new building dedication, and Indiana Academy of Ophthalmology, Indianapolis, IN Nov. 2008 Refractive surgery update. Invited speaker, Asia Pacific Academy of Cataract and Refractive Surgery, Bangkok, Thailand. Dec. 2008 Refractive surgery and cornea updates. Wilmer Current Concepts in Ophthalmology, Baltimore, MD; and Vail, CO Feb. 2009 Clinical dry eye research: an evidence based look. Alcon Resident Education Symposium (CME event). Ft. Worth, TX Feb. 2009 Modern pterygium surgery. Washington, D.C. March 2009 Refractive surgery and DSEK. Wilmer Current Concepts in Ophthalmology, Vail, CO June 2009 Ocular surface reconstruction; Femtosecond laser-assisted keratoplasty. Yale University Department of Ophthalmology Alumni Meeting, New Haven, CT Sept. 2009 Refractive surgery and DSEK. Peking Eye Center 10th Anniversary Symposium, Beijing, China. Nov. 2009 Update on ocular surface reconstruction. Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY Jan. 2010 Update on ocular surface reconstruction. New York Medical College, Valhalla, NY. Feb. 2010 Update on ocular surface reconstruction. Bronx Lebanon Medical Center, Bronx. NY. March 2010 Update on ocular surface reconstruction. Columbia U., NY, NY. April 2010 Update on ocular surface reconstruction. New York Eye and Ear Infirmary, NY, NY. June 2010 Update on ocular surface reconstruction. Mt. Sinai School of Medicine, NY, NY. July 2010 Effects of oxidative stress on corneal cell function and disease. International Congress for Eye Research, Montreal, Canada. Sept. 2010 Ocular surface reconstruction. Long Island Ophthalmological Society, Manhassett, NY. Dec. 2010 Comparison of pterygium recurrence rates in Hispanic and Caucasian patients after primary excision and conjunctival autograft. Wilmer Eye Institute, Johns Hopkins University, Current Concepts in Ophthalmology, Baltimore, MD.

44 January 2011 New chairs in ophthalmology workshop panel. AUPO meeting, Scottsdale, AZ. January 2011 Update on ocular surface reconstruction. UMDNJ, Newark, NJ. February 2011 Update on ocular surface reconstruction. Weill Cornell College of Medicine, NY, NY. March 2011 Tri-institutional Training Program in Vision Research Clinical Mini-Symposium [Cornell, Rockefeller,Mt. Sinai]. Corneal epithelial stem cell transplantation. Weill Cornell College of Medicine, NY, NY. March 2011 Comparison of pterygium recurrence rates in Hispanic and Caucasian patients after primary excision and conjunctival autograft. Wilmer Eye Institute, Johns Hopkins University, Current Concepts in Ophthalmology, Vail, CO. Sept. 2011 Annual Global Chinese Ophthalmology Conference/Chinese Ophthalmology Society Congress. Moderator and speaker, Cornea and Refractive Surgery. Guangzhou, China. October 2011 Eye care for the primary care physician. Medicine Grand Rounds, Montefiore North. October 2011 Amniotic Membrane Grafts. Cornea Subspecialty Day, AAO, Orlando, FL. Dec. 2011 Update on anti-infective and anti-inflammatory agents. U. Texas Southwestern Annual CME event. Dallas, TX. February 2012 Update on ocular surface reconstruction. Urwick Invited Lectureship, Krieger Eye Institute, Baltimore, MD. February 2012 Update on ocular surface reconstruction. New York University Grand Rounds, NY, NY. April 2012 DSEK and refractive surgery. Asia Pacific Academy of Ophthalmology. Busan, S. Korea. Dec. 2012 Ocular surface reconstruction update. Chicago Ophthalmology Society, Chicago, Il. Feb. 2013 Ocular stem cell surgery. Stern College for Women, Yeshiva University. NY, NY March 2013 Introduction to the eye doctor. Lakeville Elementary School. Great Neck, NY. March 2013 Cornea surgery. Greater New York Ophthalmology Lecture Series [MEETH]. NY, NY. June 2013 Ocular stem cell transplantation. Albert Einstein College of Medicine MD, PhD Program. NY, NY. Oct. 2013 Featured speaker. “Breaking the Silence in Asian and Pacific Islander American Health”. 20th Annual APAMSA National Conference. NY, NY. Nov. 2013 “Development of femtosecond laser keratoplasty. Chinese American Ophthalmological Society annual meeting at AAO. New Orleans, LA. January 2014 Update on ocular surface reconstruction. Visiting Professor, University of California San Diego.

45 June 2014 "Sustained release nanoparticles: a novel platform for therapeutic delivery of NO for treatment of glaucoma and other optic neuropathies". International Symposium on Ocular Pharmacology and Therapy. Reykjavik, Iceland. Sept 2014 Department of Ophthalmology Update. Montefiore Medical Group Grand Rounds. Bronx, NY. April 2015 1. Update on ocular surface reconstruction; 2. Application of refractive surgery technology to treatment corneal disease. Visiting Professor, SUNY Downstate, Brooklyn, NY. July 2015 "Nanoparticle drug delivery for glaucoma: A cornea perspective". International Symposium on Ocular Pharmacology and Therapy. Berlin, Germany. August 2015 Update on ocular surface reconstruction. Annual Ophthalmology Update Meeting, U. Mississippi Medical Center, Jackson, MI. October 2015 “Visionary Medicine: Advances in Eye Care at Montefiore- Einstein”. Einstein-Montefiore Department of Medicine, Grand Rounds, Bronx, NY. October 2015 “Ocular cicatricial pemphigoid”. Cornea Subspecialty Day, AAO meeting. Las Vegas, NV. March 2016 Asia Pacific Academy of Ophthalmology. Taipei, Taiwan. April 2016 Advances in corneal surgery: from bench to bedside. Spring Update Meeting, Alumni Lecturer, Washington University, St. Louis, MO. June 2016 1. Advances in corneal surgery: from bench to bedside; 2. Application of refractive surgery technology to treatment corneal disease. Visiting Professor, Yale U., New Haven, CT. November 2016 Advances in corneal surgery: Academic inventorship from bench to bedside. Visiting Professor Zhongshan Eye Center/Hospital, Henan Eye Center/Hospital and Tongren Eye Center/Hospital, Guangzhou, Henan and Beijing, China. Dec 2016 International Symposium on Ocular Pharmacology and Therapy. Rome, Italy. January 2017 Formulating a clinical question. Cochrane Eyes and Vision Group (Cochrane Reviews training sessions). Baltimore, MD. January 2017 Advances in corneal surgery: Academic inventorship from bench to bedside. Grand Rounds, Gavin Herbert Eye Institute, UC Irvine, CA. January 2017 7 things I wish I knew before I became Chair. Association University Professors of Ophthalmology. San Diego, CA. November 2017 Therapeutic updates from the AAO Refractive Management / Intervention Preferred Practice Pattern Panel. New Orleans, LA. January 2018 Translating technology from bench to bedside: A new device for corneal collagen cross-linking. Current Concepts in Ophthalmology. Atlantic City, NJ. January 2018 Lasers and corneal transplantation. Columbia U. Basic Science and Clinical Ophthalmology course. NYC, NY.

46 January 2018 Advances in corneal surgery: academic inventorship from bench to bedside. Columbia U. Ophthalmology Grand Rounds. NYC, NY. January 2018 Mentoring faculty to mentor students/trainees/and each other. AUPO Educating the Educator Symposium. Austin, TX.

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