IFITM3 (-induced Transmembrane 3, Dispanin Subfamily A Member 2b, DSPA2b, Interferon- inducible Protein 1-8U, Fragilis)

Catalog number 223466 Supplier United States Biological

IFITM3 (interferon induced 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of . IFITM proteins are induced by type I and type II and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in . Localizing to the membrane, IFITM3 is a 133 protein that is induced by IFN-alpha and IFN- y. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1. Applications Suitable for use in Western Blot, Immunocytochemistry. Other applications not tested. Recommended Dilution Western Blot: 1:500-1:1000 Immunocytochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Immunogen Synthetic peptide corresponding to amino acids 9-54 of Human IFITM3. Formulation Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2. Purity Purified by immunoaffinity chromatography. Specificity Recognizes endogenous levels of IFITM3. Species Crossreactivity: Human, mouse, rat Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications IC WB Crossreactivity Hu Mo Rt Storage -20°C MW 15

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