Ahmad Salman
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Female Urethra
OBJECTIVES: • By the end of this lecture, student should understand the anatomical structure of urinary system. General Information Waste products of metabolism are toxic (CO2, ammonia, etc.) Removal from tissues by blood and lymph Removal from blood by Respiratory system And Urinary system Functions of the Urinary System Elimination of waste products Nitrogenous wastes Toxins Drugs Functions of the Urinary System Regulate homeostasis Water balance Acid-base balance in the blood Electrolytes Blood pressure Organs of the Urinary system Kidneys Ureters Urinary bladder Urethra Kidneys Primary organs of the urinary system Located between the 12th thoracic and 3rd lumbar vertebrae. Right is usually lower due to liver. Held in place by connective tissue [renal fascia] and surrounded by thick layer of adipose [perirenal fat] Each kidney is approx. 3 cm thick, 6 cm wide and 12 cm long Regions of the Kidney Renal cortex: outer region Renal medulla: pyramids and columns Renal pelvis: collecting system Kidneys protected by three connective tissue layers Renal fascia -Attaches to abdominal wall Renal capsule: -Surrounds each kidney -Fibrous sac -Protects from trauma and infection Adipose capsule -Fat cushioning kidney Nephrons Each kidney contains over a million nephrons [functional structure] • Blood enters the nephron from a network that begins with the renal artery. • This artery branches into smaller and smaller vessels and enters each nephron as an afferent arteriole. • The afferent arteriole ends in a specialized capillary called the Glomerulus. • Each kidney has a glomerulus contained in Bowman’s Capsule. • Any cells that are too large to pass into the nephron are returned to the venous blood supply via the efferent arteriole. -
Urinary System
URINARY SYSTEM Ján Líška DVM, PhD Institut of Histology and Embryology, Faculty of Medicine, Comenius University Urinary system • The kidneys are the organ with multiple functions: • filtration of the blood • excretion of metabolic waste products and related removal of toxins • maintenance blood volume • regulation of acid-base balance • regulation of fluid and electrolyte balance • production of the hormones The other components of urinary system are accessory. Their function is essentially in order to eliminate urine. Urinary system - anatomy • Kidney are located in the retroperitoneal space • The surface of the kidney is covered by a fibrous capsule of dense connective tissue. • This capsule is coated with adipose capsule. • Each kidney is attached to a ureter, which carries urine to the bladder and urine is discharged out through the urethra. ANATOMIC STRUCTURE OF THE KIDNEY RENAL LOBES CORTEX outer shell columns Excretory portion medullary rays MEDULLA medullary pyramids HILUM Collecting system blood vessels lymph vessels major calyces nerves RENAL PELVIS minor calyces ureter Cortex is the outer layer surrounding the internal medulla. The cortex contains renal corpuscles, convoluted parts of prox. and dist. tubules. Renal column: the renal tissue projection between two medullary pyramids which supports the cortex. Renal pyramids: the conical segments within the medulla. They contain the ductal apparatus and stright parts of the tubules. They posses papilla - having openings through which urine passes into the calyces. Each pyramid together with the associated overlying cortex forms a renal lobe. renal pyramid papilla minor calix minor calyx Medullary rays: are in the middle of cortical part of the renal lobe, consisting of a group of the straight portiones of nephrons and the collec- medullary rays ting tubules (only straight tubules). -
Lab-Renal-2018-Zw4m.Pdf
Introduction The slides for this lab are located in the “Urinary System” folders on the Virtual Microscope. In this lab, you will learn about the structures within the kidney required to filter the blood and the tubes required to transport the resulting waste products outside the body. The journey begins in the unit of the kidney called the nephron. Here the blood is filtered, products are reabsorbed and then some are secreted again, based on the body’s current state. Dissolved in water, these products then travel through the conducting portion of the kidney to the ureters. The ureters insert on the urinary bladder obliquely and posteriorly. The urinary bladder temporarily stores urine until it can be conveniently evacuated. Urine exits the body through the urethra. Learning objectives and activities Using the Virtual Slidebox: A Outline a renal lobe and identify the structural components of a renal lobule B Examine the components of the renal corpuscle: glomerulus and Bowman’s capsule C Classify the different areas of the renal tubules based upon their histological appearance and location D Compare the structures of the excretory passageways and use this information to identify them E Complete the self-quiz to test your understanding and master your learning Outline a renal lobe and identify the structural components of a renal lobule Examine Slide 1 and approximate a renal lobe in the kidney by identifying the following: Each kidney can be divided into somewhere between 8-15 renal lobes. Each lobe consists of a medullary pyramid capped by the cortex and flanked by renal columns with a renal papilla at its apex. -
Ward's Renal Lobule Model
Ward’s Renal Lobule Model 470029-444 1. Arcuate artery and vein. 7. Descending thick limb of 12. Collecting tubule. 2. Interlobular artery and vein. Henle's loop. 13. Papillary duct of Bellini. 3. Afferent glomerular arteriole. 8. Thin segment of Henle's 14. Vasa recta. loop. 4. Efferent glomerular arteriole. 15. Capillary bed of cortex (extends 9. Ascending thick limb of through entire cortex). 5. Renal corpuscle (glomerulus Henle's loop. plus Bowman's capsule). 10. Distal convoluted tubule. 16. Capillary bed of medulla (extends 6. Proximal convoluted tubule. 11. Arched connecting tubule. through entire medulla). MANY more banks of glomeruli occur in the cortex than are represented on the model, and the proportionate length of the medullary elements has been greatly reduced. The fundamental physiological unit of the kidney is the nephron, consisting of the glomerulus, Bowman's capsule, the proximal convoluted tubule, Henle's loop, and the distal convoluted tubule. The blood is filtered in the glomerulus, water and soluble substances, except blood proteins, passing into Bowman's capsule in the same proportions as they occur in the blood. In the proximal tubule water and certain useful substances are resorbed from the provisional urine, while some further components may be added to it by secretory activity on the part of the tubular epithelium. In the remainder of the tubule, resorption of certain substances is continued, while the urine is concentrated further by withdrawal of water. The finished urine flows through the collecting tubules without further change. Various kinds of loops occur, varying in length of the thin segment, and in the level to which they descend into the medulla. -
Urinary System
OUTLINE 27.1 General Structure and Functions of the Urinary System 818 27.2 Kidneys 820 27 27.2a Gross and Sectional Anatomy of the Kidney 820 27.2b Blood Supply to the Kidney 821 27.2c Nephrons 824 27.2d How Tubular Fluid Becomes Urine 828 27.2e Juxtaglomerular Apparatus 828 Urinary 27.2f Innervation of the Kidney 828 27.3 Urinary Tract 829 27.3a Ureters 829 27.3b Urinary Bladder 830 System 27.3c Urethra 833 27.4 Aging and the Urinary System 834 27.5 Development of the Urinary System 835 27.5a Kidney and Ureter Development 835 27.5b Urinary Bladder and Urethra Development 835 MODULE 13: URINARY SYSTEM mck78097_ch27_817-841.indd 817 2/25/11 2:24 PM 818 Chapter Twenty-Seven Urinary System n the course of carrying out their specific functions, the cells Besides removing waste products from the bloodstream, the uri- I of all body systems produce waste products, and these waste nary system performs many other functions, including the following: products end up in the bloodstream. In this case, the bloodstream is ■ Storage of urine. Urine is produced continuously, but analogous to a river that supplies drinking water to a nearby town. it would be quite inconvenient if we were constantly The river water may become polluted with sediment, animal waste, excreting urine. The urinary bladder is an expandable, and motorboat fuel—but the town has a water treatment plant that muscular sac that can store as much as 1 liter of urine. removes these waste products and makes the water safe to drink. -
8.5 X12.5 Doublelines.P65
Cambridge University Press 978-0-521-87702-2 - Silva’s Diagnostic Renal Pathology Edited by Xin J. Zhou, Zoltan Laszik, Tibor Nadasdy, Vivette D. D’Agati and Fred G. Silva Excerpt More information CHAPTER 1 CHAPTER Chapter 1 Renal Anatomy William L. Clapp, MD GROSS ANATOMY Glomerulus Location, Size, and Shape General Features Blood Supply Endothelial Cells Mesangium Form of Kidney (Mesangial Cells) NEPHRONS (Mesangial Matrix) Nephron Number GBM Nephron Types Podocytes Glomerular Filtration Barrier ARCHITECTURE Parietal Podocytes Cortex Parietal Epithelial Cells Cortical Labyrinth and Medullary Rays Peripolar Cells Renal Lobule JGA Medulla Tubules Outer Medulla Proximal Tubule Inner Medulla Thin Limbs of Henle’s Loop Algorithm for Architecture Distal Tubule PARENCHYMA (TAL) Vasculature (DCT) Connecting Tubule Macrovasculature Collecting Duct Microvasculature (Cortical Collecting Duct) (Cortex) (OMCD) (Medulla) (IMCD) Lymphatics Interstitium Nerves Knowledge of the elaborate structure of the kidney provides GROSS ANATOMY insight into its functions and facilitates an understanding of renal diseases. One cannot recognize what is abnormal in the Location, Size, and Shape kidney if one does not know what is normal. The following The retroperitoneum is divided into fascia-enclosed compart- sections consider the macroanatomy, functional units, architec- ments, including the anterior pararenal, perirenal, and posterior tural organization, microanatomy, and basic functions of the pararenal spaces. The kidneys lie within the perirenal space, which kidney. Unless otherwise stated, the illustrations will emphasize contains abundant fat and is enclosed by the anterior and posterior the human kidney. For additional information, readers are layers of renal fascia, known as Gerota’s fascia.The kidneys extend referred to several detailed reviews [1–4]. -
Kidney in an Effort to Aid Health Information Management Coding Professionals for ICD-10, the Following Anatomy Tip Is Provided with an Educational Intent
Anatomy Tip Kidney In an effort to aid Health Information Management Coding Professionals for ICD-10, the following anatomy tip is provided with an educational intent. The kidneys are the main part of the urinary system and are a pair of organs; right and left; located in the back of the abdomen. Each kidney is about 4 or 5 inches long. • The kidneys are surrounded by three layers of tissue: • The renal fascia is a thin, outer layer of fibrous connective tissue that surrounds each kidney (and the attached adrenal gland) and fastens it to surrounding structures. • The adipose capsule is a middle layer of adipose (fat) tissue that cushions the kidneys. • The renal capsule is an inner fibrous membrane that prevents the entrance of infections. • There are three major regions inside the kidney: • The renal cortex borders the convex side. • The renal medulla lies adjacent to the renal cortex. It consists of striated, cone-shaped regions called renal pyramids (medullary pyramids), whose peaks, called renal papillae, face inward. The unstriated regions between the renal pyramids are called renal columns. • The renal sinus is a cavity that lies adjacent to the renal medulla. The other side of the renal sinus, bordering the concave surface of the kidney, opens to the outside through the renal hilus. The ureter, nerves, and blood and lymphatic vessels enter the kidney on the concave surface through the renal hilus. The renal sinus houses the renal pelvis, a funnel-shaped structure that merges with the ureter. • All the blood in our bodies passes through the kidneys several times a day. -
Functions of Kidney & Artificial Kidneys
ISSN 2321 – 2004 INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH IN ELECTRICAL, ELECTRONICS, INSTRUMENTATION AND CONTROL ENGINEERING Vol. 1, Issue 1, April 2013 Functions of kidney & artificial kidneys Raghavendra1, Mallikarjun2, Vidya M.J3 Student, Instrumentation Technology, R.V.C.E, Bangalore, India 1 Student, Instrumentation Technology, R.V.C.E, Bangalore, India 2 Assistant Professor, Instrumentation Technology, R.V.C.E, Bangalore, India 3 Abstract: Renal failure is a term to describe a situation when the kidneys fail to work. This may be a permanent or temporary failure. When the kidneys fail, Wastes begin to accumulate in the blood (uremia) As homeostasis is upset within the body, other organs can also begin to shut down – heart, liver, etc. The end result of renal failure is usually death unless the blood is filtered by some other means. The ideal intervention is to replace the failed kidneys with a donor kidney (STSE).While a person waits for a donor kidney, they usually have to undergo dialysis, a method where their blood is filtered and cleaned on a regular basis using machines. Keywords: uraemia, homeostasis, Palpation, Elasticity I. INTRODUCTION The kidneys are organs that serve several essential of kidney stones is a sharp pain in the medial/lateral regulatory roles in most animals, including vertebrates and segments of the lower back. some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the II. ANATOMY regulation of electrolytes, maintenance of acid–base A. Location balance, and regulation of blood pressure (via maintaining salt and water balance). They serve the body as a natural In humans the kidneys are located in the abdominal cavity, filter of the blood, and remove wastes which are diverted more specifically in the paravertebral gutter and lie in a to the urinary bladder. -
Laparoscopic Colectomy for a Patient with Congenital Renal Agenesis
[Downloaded free from http://www.jstcr.org on Monday, October 07, 2013, IP: 41.135.175.93] || Click here to download free Android application for this journal cASE REPORt Laparoscopic Colectomy for a Patient with Congenital Renal Agenesis Hiroyuki Tanishima, Tetsuya Horiuchi, Yoshiharu Shono, Masamichi Kimura Department of Surgery, National Hospital Organization, ABSTRACT Osaka Minami Medical Center, Osaka, Japan We present a very rare case of laparoscopic colectomy for a patient with ascending colon cancer and an agenetic INTRODUCTION right kidney. A 57-year-old man visited our institute for further evaluation for a positive fecal occult blood test. ongenital unilateral renal agenesis is a rare Approximately, 20 years earlier, the right kidney of the patient condition. In patients with the congenital absence was found to be congenitally absent. A physical examination indicated no anatomical anomalies in his genitourinary [1] Cof the kidney, the renal fascia is also absent. Here, system, and the renal function was within the normal range. for the first time, we report the case of a patient with Total colonoscopy revealed a cancer of the ascending cancer of the ascending colon and right renal agenesis who colon and laparoscopic colectomy was performed. The was treated by laparoscopic colectomy, and discussed the right colon was mobilized by lateral-to-medial extension of a retroperitoneal dissection between the fusion fascia and presence of the anterior renal fascia in such cases based on the anterior renal fascia. The right testicular vessels were our experience and from a review of the literature. preserved without injury to the anterior renal fascia; however, the right ureter could not be detected. -
Urinary System
Urinary System Urinary System Urinary System - Overview: Major Functions: 1) Removal of organic waste products Kidney from fluids (excretion) 2) Discharge of waste products into the environment (elimination) 1 3) Regulation of the volume / [solute] / pH 3 of blood plasma Ureter HOWEVER, THE KIDNEY AIN’T JUST FOR PEE’IN… Urinary bladder • Regulation of blood volume / blood pressure (e.g., renin) • Regulation of red blood cell formation (i.e., erythropoietin) 2 • Metabolization of vitamin D to active form (Ca++ uptake) Urethra • Gluconeogenesis during prolonged fasting Marieb & Hoehn (Human Anatomy and Physiology, 8th ed.) – Figure 25.1 1 Urinary System Renal ptosis: Kidneys drop to lower position due Functional Anatomy - Kidney: to loss of perirenal fat Located in the superior lumbar “Bar of soap” region 12 cm x 6 cm x 3 cm 150 g / kidney Layers of Supportive Tissue: Renal fascia: Peritoneal cavity Outer layer of dense fibrous connective tissue; anchors kidney in place Perirenal fat capsule: Fatty mass surrounding kidney; cushions kidney against blows Fibrous capsule: Transparent capsule on kidney; prevents infection of kidney from local tissues Kidneys are located retroperitoneal Marieb & Hoehn (Human Anatomy and Physiology, 8th ed.) – Figure 25.2 Urinary System Functional Anatomy - Kidney: Pyelonephritis: Inflammation of the kidney Pyramids appear striped due to parallel arrangement of capillaries / collecting tubes Renal cortex Renal medulla Renal pyramids Renal papilla Renal columns Renal hilum Renal pelvis • Entrance for blood vessels -
URINARY Objectives
URINARY Objectives Students should be able to: 1. Describe the microscopic structure of the kidney cortex, medulla and renal pelvis; also the ureter and bladder. 2. Identify the histological features of the kidney, ureter and bladder. Kidney H & E stain General Histological Structure Low power magnification. Note the major features of a cross section through the kidney. Identify : renal capsule, cortex (deep staining zone), medulla and renal corpuscles. : renal corpuscles medulla cortex renal capsule 1.0mm Kidney Alkaline phosphatase stain General Histological Structure Identify : cortex , renal corpuscles, convoluted tubules and medullary rays. What does the term medullary rays imply? In the cortex- groups of radially arranged straight tubules form the cortical or medullary rays (pars radiata) section from cortex convoluted tubules renal corpuscle medullary ray 250 µm Kidney Detailed Histology Examine the structure of a renal corpuscle and appreciate how the filtration unit has been constructed. What constitutes the filter here? 1. Porous endothelium of capillaries. 2. Glomerular basement membrane. 3. Podocyte pedicels. U : urinary space Pd : podocyte Pd Pl : parietal layer U Pl proximal tubule 50 µm Kidney Detailed Histology Where does the filtrate collect? In the urinary space. What further changes take place in its composition before it is fully excreted? Extensive re-absorption (66-75%) of this glomerular filtrate in the proximal tubules. U : urinary space U 50 µm Kidney Detailed Histology What is the difference between vascular and urinary poles of the renal corpuscle? Why are they given these names? Vascular pole- with afferent and efferent arteriole blood supply. Urinary pole- with the start of the proximal convoluted tubule. -
Kidney Structure Renal Lobe Renal Lobule
Kidney Structure Capsule Hilum • ureter → renal pelvis → major and minor calyxes • renal artery and vein → segmental arteries → interlobar arteries → arcuate arteries → interlobular arteries Medulla • renal pyramids • cortical/renal columns Cortex • renal corpuscles • cortical labryinth of tubules • medullary rays Renal Lobe Renal Lobule = renal pyramid & overlying cortex = medullary ray & surrounding cortical labryinth Cortex Medulla Papilla Calyx Sobotta & Hammersen: Histology 1 Uriniferous Tubule Nephron + Collecting tubule Nephron Renal corpuscle produces glomerular ultrafiltrate from blood Ultrafiltrate is concentrated • Proximal tubule • convoluted • straight • Henle’s loop • thick descending • thin • thick ascending • Distal tubule • Collecting tubule Juxtaglomerular apparatus • macula densa in distal tubule •JG cells in afferent arteriole •extraglomerular mesangial cells Glomerulus • fenestrated capillaries • podocytes • intraglomerular mesangial cells 2 Urinary Filtration Urinary Membrane Membrane Podocytes • Endothelial cell • 70-90 nm fenestra restrict proteins > 70kd • Basal lamina • heparan sulfate is negatively charged • produced by endothelial cells & podocytes • phagocytosed by mesangial cells • Podocytes • pedicels 20-40 nm apart • diaphragm 6 nm thick with 3-5 nm slits • podocalyxin in glycocalyx is negatively charged 3 Juxtaglomerular Apparatus Macula densa in distal tubule • monitor Na+ content and volume in DT • low Na+: • stimulates JG cells to secrete renin • stimulates JG cells to dilate afferent arteriole • tall,