March 30, 2020 PROFESSOR LUCILA OHNO-MACHADO, Chair UC San

ACADEMIC SENATE: SAN DIEGO DIVISION, 0002 UCSD, LA JOLLA, CA 92093-0002 (858) 534-3640 FAX (858) 534-4528

March 30, 2020

PROFESSOR LUCILA OHNO-MACHADO, Chair UC San Diego Health, Department of Biomedical Informatics

PROFESSOR JAMES McKERROW, Dean Skaggs School of Pharmacy and Pharmaceutical Sciences

SUBJECT: Proposed MS in Health Informatics

At its March 9, 2020 meeting, the Graduate Council approved the proposal to establish a new self-supporting professional graduate degree program of study leading to a Master of Science (M.S.) in Health Informatics. The Graduate Council will forward the proposal for placement on the April 21, 2020 Representative Assembly agenda.

Please note that proposers may not accept applications to the program or admit students until systemwide review of the proposal is complete and the UC Office of the President has issued a final outcome.

Sincerely,

Lynn Russell, Chair Graduate Council cc: M. Allen J. Antony S. Constable M. Corr M. Day W. Dillmann R. Rodriguez

A Self-Supporting Professional Graduate Degree Program in Health Informatics for the Master of Science degree

Led$By$ $ Department$of$Medicine,$$ Division$of$Biomedical$Informatics$ In$Collaboration$With$ Skaggs$School$of$Pharmacy$and$Pharmaceutical$Sciences$ $ $ $ $ University$of$California$San$Diego$|$2019$

1" " Health'Informatics'Master'of'Science' Program'Proposal' ' ' ' Contact'Information'Sheet' " " Lead'Proponents:"" " Lucila"Ohno.Machado,"MD,"PhD" " " " Professor"of"Medicine" Chair,"UC"San"Diego"Health,"Department"of"Biomedical"Informatics" Associate"Dean"for"Informatics"and"Technology" UC"San"Diego" [email protected]"" " James"McKerrow,"MD,"PhD" Distinguished"Professor" Dean" Skaggs"School"of"Pharmacy"and"Pharmaceutical"Sciences" Associate"Vice"Chancellor"for"Health"Sciences" Distinguished"Professor"of"Pathology" [email protected]"" " Other'Contacts:'' " " " " Robert"El.Kareh,"MD,"MS,"MPH" Associate"Clinical"Professor" Associate"Director,"Biomedical"Informatics"Postdoctoral"Program" Division"of"Biomedical"Informatics" Department"of"Medicine" [email protected]"" " Michele"Day,"PhD" Program"Manager" Associate"Director,"Biomedical"Informatics"PhD"Program" Division"of"Biomedical"Informatics" Department"of"Medicine" [email protected]" " Nancy"Herbst" Director" Division"of"Biomedical"Informatics" Department"of"Medicine" [email protected]"" "

2" " Health'Informatics'Master'of'Science'Program'Proposal' ' Table'of'Contents' " Contents' Contact"Information"Sheet"...... "2" Table"of"Contents"...... "3" Executive"Summary"...... "4" I." Section"1."Introduction"...... "5" Table"1."Competitive"Scan"of"Master’s"programs"across"the"U.S."...... "8" II." Section"2."Program"...... "11" Core"Courses"...... "12" Electives""...... "13" Health"Informatics"Plan"I:"Thesis"...... "15" Health"Informatics"Plan"II:"Comprehensive"Examination"...... "15" Table"2."Elective"Options"...... "16" III." Section"3:"Projected"Need"...... "17" IV." Section"4."Faculty"...... "20" Table"3."Program"Faculty*"from"DBMI"and"SSPPS"...... "21" V." Section"5."Courses"...... "22" Table"4."Sample"Program"of"Study"...... "22" VI." Section"6."Resource"Requirements"(Estimated"for"the"first"5"years)"...... "23" VII." Section"7."Graduate"Student"Support"...... "26" VIII." Section"8."Governance"...... "26" IX." Section"9."Changes"in"Senate"Regulations"...... "26" X." Financial"Accessibility"and"Impact"on"State.Supported"Programs"...... "27" XI." Impact"on"State.Supported"Programs"...... "27" XII." Optional"Appendices"...... "27" Appendix"I:"MS"Health"Informatics"Admission"Score"Sheet"...... "35" Appendix"II:"Course"Descriptions...... "36" Appendix"III:"Course"Approval"Forms"...... "38" Appendix"IV:"Anticipated"Impact"of"New"courses"on"Existing"Courses"at"UCSD"...... "44" Appendix"V:"Draft"Catalog"Copy"...... "48" Appendix"VI:"Budget,"Chancellor"and"VC"letters,"and"Campus"Budget"Office"Reviews"...... "54" Appendix"VII:"Feedback"from"Campus"Review"Committees"and"Other"Entities"...... "62" Appendix"VIII:"References"...... "84" Appendix"IX:"Letters"of"Support"from"Department"of"Medicine"and"Related"Programs"...... "85" Appendix"X:"Combined"CVs/Biosketches"for"Program"Faculty"...... "89" "

3" " Health'Informatics'Master'of'Science'Program'Proposal' ' ' ' Executive"Summary' The"proposed"self.sustaining"program"will"award"the"MS"in"Health"Informatics"and"will"be" housed"in"the"Department"of"Medicine."The"program"will"be"governed"by"the"Division"of" Biomedical"Informatics"(DBMI)"and"will"involve"collaboration"with"the"Skaggs"School"of" Pharmacy"and"Pharmaceutical"Sciences"(SSPPS)."The"participating"faculty"include"10" members"of"DBMI"and"7"members"of"SSPPS."We"are"not"pursuing"additional"faculty"FTE"for" the"program."

Health"informatics"and"health"information"management"is"poised"for"continued"growth" according"to"the"US"Bureau"of"Labor"Statistics."Many"of"these"positions"require"and"benefit" from"formal"training"at"the"Master’s"level."The"program"targets"domestic"and"international" students"with"health.related"degrees"seeking"to"enhance"their"ability"to"analyze"and"use"the" ever.growing"amounts"of"data"to"improve"health."To"provide"a"world.class"health"informatics" training"experience"and"to"attract"qualified"candidates,"the"proposed"program"will"take" advantage"of"key"distinguishing"features"of"UC"San"Diego."These"features"include:"(1)" knowledgeable"academic"faculty"in"Health"Informatics"across"a"wide"range"of"clinical" disciplines,"including"general"and"specialized"medical"and"pharmacy"backgrounds;"(2)"a"close" and"synergistic"relationship"between"academic"and"operational"informatics"groups"within"a" world.class"academic"medical"center;"and"(3)"relationships"with"and"proximity"to"a"leading" bio.tech"industry."These"characteristics"provide"a"significant"competitive"advantage"over" other"informatics"training"programs"in"Southern"California"and"place"us"in"the"top"tier"of" training"programs"nationally."

The"proposed"degree"will"consist"of"48"units"and"will"offer"either"thesis"or"comprehensive" examination"options."Students"may"elect"to"pursue"the"degree"full."or"part.time."The" curriculum"will"include"an"overview"of"the"broad"field"of"Biomedical"Informatics,"cutting.edge" analytic"techniques,"pharmacogenomics"and"clinical"data"modeling."In"addition,"to"prepare" students"to"have"substantial"impact"as"they"enter"the"workforce,"the"program"includes" training"in"clinical"informatics"within"healthcare"settings"and"in"change"management"and" organizational"change."We"anticipate"our"first"class"to"enter"in"the"Fall"of"2020." " 4" " " I.! Section'1.'Introduction' A.! Aims"and"Objectives:" The"Master"of"Science"(MS)"Program"in"Health"Informatics"will"be"a"one."to"two.year" program"providing"graduate"training"that"prepares"students"in"the"application"of"biomedical" informatics"to"clinical"systems,"across"the"health"care"sector."The"program"combines"theory" with"focused"applications"likely"to"impact"on"health"and"welfare"of"the"public"at"multiple" levels"and"will"be"conducted"with"a"30.student"residential"cohort."Our"target"students" include"healthcare"professionals"and"graduate"students"in"technological"fields"interested"in" informatics"careers."The"ultimate"career"goals"following"completion"are"expected"to"range" from"informatics"director,"chief"medical"information"officer,"pharmacy"or"nursing" informaticist,"consulting,"and"academia."We"are"confident"that"our"program"will"prepare" students"well"for"this"range"of"careers."Initially,"we"expect"that"several"students"will"come" from"local"healthcare"organizations"and"universities."Our"unique"focus"on"collaborative" work"between"medical"and"pharmacy"specialists"will"likely"attract"several"students"with" pharmacy"backgrounds"or"interest."The"program"will"cover"fundamental"aspects"of"Health" Informatics"(comprised"of"Clinical"Informatics"and"Public"Health"Informatics)."We"expect"to" start"with"a"split"of"in.state"and"out.of.state"applicants"and"to"broaden"to"international" students"quickly."We"anticipate"that"the"career"goals"of"out.of.state"and"international" students"will"be"similar"to"those"from"in.state."

B.! Historical"Development"of"the"Field:" The"field"of"Health"Informatics"has"been"evolving"since"the"1960s."In"1959,"Ledley"and" Lusted"published"a"landmark"article"describing"the"potential"of"computers"to"aid"in"the" complex"process"of"medical"diagnosis.1""Since"that"time,"information"technology"has" permeated"all"aspects"of"health"care—from"clinical"documentation,"imaging"and"laboratory" test"result"management,"billing"and"patient.provider"and"provider.provider" communication.2"Adoption"of"electronic"health"records"(EHRs)"in"the"US"has"been"supported" by"federal"incentives"and"has"continued"to"expand.3"As"the"field"matures,"we"are"continuing" to"learn"how"best"to"use"our"electronic"clinical"data"to"measure"our"care"processes,"support" clinical"decisions"and"lower"the"cost"of"innovative"research—all"with"the"common"goal"of" improving"the"quality,"safety"and"efficiency"of"patient"care." " The"Academic"Forum"from"AMIA,"the"leading"academic"informatics"group"in"the"US,"describe" health"informatics"as"the"combination"of"clinical"informatics"and"public"health"informatics.4"

5" This"field"is"a"subset"of"biomedical"informatics,"which"encompasses"areas"ranging"from" molecular"analysis"to"population"health." " With"all"the"promises"of"health"information"technology"(HIT),"many"barriers"have"arisen." For"example,"introducing"technology"into"the"patient.provider"relationship"has"at"times"had" a"negative"impact"on"this"vital"interaction.5"Early"work"has"shown"that"if"HIT"is"not" integrated"into"clinical"workflows"properly,"it"can"lead"to"provider"dissatisfaction"and" seemingly"paradoxical"inefficiencies.6"In"addition,"the"lack"of"widespread"use"of"standard" formats"for"capturing"and"storing"clinical"data"has"hindered"efforts"to"share,"aggregate"and" learn"from"data"across"multiple"settings.7,8"

" Our"health"care"system"is"undergoing"a"significant"transformation"and"health"informatics"is" at"its"heart."Improving"our"use"of"health"information"is"the"foundation"of"evidence.based" care,"personalized"or"precision"medicine"and"the"establishment"of"true"learning"health"care" systems."To"reach"these"important,"but"challenging"goals,"we"must"continue"to"expand"our" supply"of"motivated"professionals"with"expertise"in"health"informatics." " According"to"the"US"Bureau"of"Labor"Statistics,"employment"for"health"information" managers"is"expected"to"grow"by"23%"from"2012"to"2022.9""This"growth"outlook"aligns"with" the"outlook"projected"in"2016"(19%"growth"from"2015"through"2020).""Similarly,"UCSD" Extension"conducted"an"evaluation"of"industry"trends"in"Fall,"2018"and"found"that"the" clinical"informatics"job"market"is"growing"and"projected"to"grow"further"with"the"overall" healthcare"informatics"market.""Specifically,"the"clinical"segment"of"the"healthcare" informatics"market"is"expected"to"grow"along"with"the"overall"healthcare"informatics" market." "

C.! Timetable"for"Development"of"the"Program:" •! Goal:"enroll"the"first"health"informatics"class"in"Fall"2020."

•! We"project"a"steady.state"of"30"enrolled"candidates"per"year.""We"do"not"anticipate" that"any"of"the"local"programs"would"have"their"enrollments"reduced"to"accommodate."" We"expect"that"our"candidates"would"be"from"a"pool"who"would"not"have"enrolled"at" UCSD"otherwise."The"program"is"proposed"as"a"Self.Supporting"Graduate"Professional" Degree"Program"(SSGPDP)"as"this"structure"is"consistent"with"program"goals"based"on" the"UCOP"SSGPDP"Policy.""The"program"will"target"students"beyond"those"supported" through"State"resources"with"the"goal"of"fulfilling"a"clear"workforce"need"in"health"

6" informatics.""All"of"the"program"costs"will"be"covered"by"revenues"generated"by"the" program.""The"funds"used"will"not"include"State"General"Funds"or"tuition"and"fees"of" state.supported"programs.""In"addition,"the"program"will"not"be"supported"by"any" Compulsory"Campus.based"Student"Fees"and"Course"Materials"and"Services"Fees" (CMSF).We"will"start"our"program"as"a"fully"on.campus"on"program"and"during"the" first"two"years,"we"plan"to"transition"to"offer"several"of"our"courses"online"to"better" accommodate"students"who"are"not"in"San"Diego"to"enhance"program"reach"and" sustainability."

D.! Relation"of"the"proposed"program"to"existing"programs"and"to"the"campus"Academic"Plan:"

•! We"conducted"a"competitive"scan"of"the"programs"in"the"San"Diego"area"and"nationally" (see"Table"1)."Our"program’s"strengths"include"close"ties"with"an"advanced"medical" center,"enabling"students"to"have"access"to"clinical"settings,"electronic"health"records," as"well"as"the"opportunity"to"work"with"faculty"who"are"actively"involved"with"the" medical"center."UCSD"Health"Sciences"is"the"only"state.owned"academic"medical"center" in"the"area,"and"is"also"home"for"our"Comprehensive"Cancer"Center,"the"Clinical"and" Translational"Research"Institute,"the"Supercomputer"Center,"and"the"Qualcomm" Institute."In"addition,"San"Diego"is"a"hub"for"biotech"and"pharmaceutical"companies" affording"students"the"unique"opportunity"to"apply"for"internships"or"collaborative" projects"with"industrial"partners."While"other"programs’"cost"may"be"lower,"UC"San" Diego"has"a"long.standing"prestigious"reputation"and"is"currently"ranked"20th"by"U.S." News"in"the"area"of"clinical"medicine.""UC"San"Diego"also"continues"to"grow"with" research"funding."" •! The"Division"of"Biomedical"Informatics"(DBMI)"within"the"Department"of"Medicine" and"the"Skaggs"School"of"Pharmacy"and"Pharmaceutical"Sciences"(SSPPS)"consider" health"informatics"a"key"growth"area"for"UCSD."Several"faculty"hires"have"occurred"in" both"departments"that"make"this"program"possible"to"move"forward." •! The"program"is"proposed"as"a"Master"of"Science"for"two"main"reasons:""(1)"although" the"topics"covered"within"the"program"provide"a"broad"background"in"health" informatics,"there"is"a"substantial"analytical"and"research"focus"in"the"curriculum" and"(2)"many"other"top"academic"institutions"in"the"informatics"field"provide"an"MS" in"health"informatics,"biomedical"informatics"or"similar"fields"against"which"our" students"will"compare"our"program"(e.g.,""Stanford"University,"Indiana"University," University"of"Wisconsin"at"Madison,"University"of"North"Carolina"."Charlotte," Northeastern"University)."

7" •! This"new"MS"program"is"consistent"with"Goal"#3"of"the"UC"San"Diego"Campus" Strategic"Plan"to"“Increase"the"graduate"student"population"and"further"protect"and" enhance"the"quality"of"the"student"body”"as"laid"out"in"the"UCSD"2014"Strategic"Plan" (http://plan.sdsc.edu/documents/Exec.Summary.Strategic."Plan.pdf)." " Table'1.'Competitive'Scan'of'Master’s'programs'across'the'U.S.''

Program UW)Seattle University3of3Michigan George3Mason3University UC3Davis MS%%in%Health%Informatics%&%Health%Information% Type%of%degree Management MS%in%Health%Informatics MS%in%Health%Informatics MS%in%Health%Informatics Number%of%units 81 52 49.5 43 $27,918%($564%/%credit) Total%cost $51,000% $28771%(resident) $44,550%($900%/%credit%online) $41,589%(CA%resident) Format Executive%(1%weekend/mo%+%online) onUcampus%(2%years) OnlineUonly%(2.5%years)%vs.%onUcampus%only onUcampus%only? Thesis No Option Yes Capstone Yes Option No Comments%relative%to% UCSD%MSHI Less%analytical,%more%leadership,%capstone%is%applied Core%courses,%internship Not%clearly%linked%with%med%center

Program UNC)Charlotte Indiana3University University3of3Utah University3of3Kansas Type%of%degree MS%in%Health%Informatics MS%in%Health%Informatics MS%in%Biomedical%Informatics MS%in%Health%Informatics Number%of%units 54 54 45 60 Total%cost $12,348%(resident) $28,110%(resident) $26,449%(resident) $28,000%(resident) Format onUcampus%(evenings) onUcampus online%only%or%onUcampus%only hybrid Thesis No Option No No Capstone No Option Yes No Comments%relative%to% 3%tracks:%%Applied%CI,%Bioinformatics,%Data%science UCSD%MSHI Industry%internship%&%practicum No%clear%link%with%medical%center No%clear%link%to%medical%center Practicum

Program University3of3Pittsburgh University3of3Wisconsin3Milwaukee University3of3San3Diego Harvard Type%of%degree MS%in%Biomedical%Informatics MS%in%Health%Care%Informatics MS%in%Health%Care%Informatics MS%in%Biomedical%Informatics Number%of%units 54 32%(no%thesis)%U35%(thesis) 42 36 Total%cost $11,883.60 $64,470%(onUcampus);%$34,225%(online) $102,500%($51,250/yr,%assuming%2%yr%program) Format onUcampus? fully%online,%unclear%about%inUperson%option online%or%onUcampus onUcampus Thesis Optional Option No No Capstone Research%Project Option Yes Yes Comments%relative%to% Requires%oral%comprehensive%examination Also%has%residency%at%clinical%site UCSD%MSHI No%clear%link%with%med%center No%clear%link%with%med%center Nursing%focus AnalyticsUfocused

Program OHSU National3University UCSD33)3Proposal Type%of%degree MS%in%Health%and%Clinical%Informatics MS%Health%Informatics MS%in%Health%Informatics Number%of%units 55 54 52 $45,000%(nonUthesis,%on%campus) $46,000%(nonUthesis,%online) Total%cost $47,000%(thesis,%on%campus) $23,220 $55,943 Format online%and%onUcampus online%and%onUcampus onUcampus Thesis Option No Option Capstone Option? Yes Option Comments%relative%to% UCSD%MSHI

E.! Contributions"to"diversity:"

Vision"for"supporting"diversity:"The"Division"of"Biomedical"Informatics"(DBMI)"at"UCSD" strongly"emphasizes"the"recruitment"of"a"diverse"group"of"staff,"faculty,"and"trainees."Our"goal" is"that"our"program"is"diverse"and"welcoming"to"students"of"all"backgrounds."We"do"not"collect" self.identified"race,"ethnicity,"and"gender"information"on"all"of"our"trainees."For"the"62" trainees"directly"funded"by"the"NLM"who"chose"to"provide"this"information,"31"(50%)"were" women"and"16"(26%)"were"URMs."""

Data"science"skills,"which"informatics"encompass,"are"among"the"most"in.demand"workforce" skill"sets.""A"2016"Gallup"poll"among"higher"education"institutions"and"businesses"found"that," by"2021,"as"high"as"69%"of"employers"will"prefer"candidates"with"data"skills,"while"only"23%" of"educational"leaders"said"their"graduates"would"be"well"equipped"to"meet"this"demand." What"is"more"alarming"is"that"only"12%"of"educational"leaders"felt"that"data"courses"may"

8" attract"Under.Represented"Minority"(URM)"students"as"compared"to"other"already"diversity. scarce"STEM"fields.""

The"proposed"program"will"be"established"alongside"existing"efforts"to"recruit"and"retain" URMs"into"the"field"of"informatics."Since"barriers"to"URMs"entering"informatics"occur"during" several"points"(e.g.,"lack"of"technical"training,"inadequate"graduate"admission"preparation," lack"of"exposure"to"programming,"etc.),"DBMI’s"goals"are"to"provide"a"multi.pronged"approach" for"recruiting,"retaining"and"placing"diverse"trainees"throughout"the"career"continuum."The" proposed"program"in"Health"Informatics"will"be"a"part"of"these"coordinated"efforts."

Identification,"recruitment"and"retention"of"underrepresented"minority"students"and"faculty:"" To"identify,"recruit"and"retain"URM"students,"we"will"undertake"a"few"efforts."First,"we"will" reach"out"to"a"wide"range"of"undergraduate"organizations"to"raise"awareness"of"our"program." We"will"ensure"that"our"outreach"will"include"schools"with"diverse"student"bodies."In"addition," we"will"continue"to"leverage"our"successful"summer"internship"program"at"DBMI,"which" provides"an"introduction"into"the"field"of"informatics"and"can"help"spark"an"interest"in" pursuing"graduate"studies."DBMI"has"a"National"Library"of"Medicine.funded"training"program" and"provides"funding"specifically"for"URMs"in"these"short.term"training"positions."These" funded"slots"will"provide"additional"opportunities"to"identify"and"recruit"URM"candidates"for" the"proposed"program.""

To"enhance"retention,"we"will"be"proactive"about"addressing"known"barriers"for"graduate" students—barriers"often"amplified"for"URM"students."One"barrier"is"that"of"“imposter" syndrome,”"a"condition"where"one"feels"inadequate"or"unworthy"of"their"success"or" accomplishments"despite"evidence"suggesting"otherwise."We"will"work"to"mitigate"this"barrier" by"educating"students"about"its"existence"and"its"frequency"at"all"levels"of"experience"and"by" providing"students"advice"and"information"about"how"to"combat"this"mentality"with" mentorship"and"peer"support."We"will"also"promote"student"involvement"in"special"interest" groups"(e.g.,"Society"of"Women"Engineers,"National"Society"of"Black"Engineers,"Society"of" Hispanic"Professional"Engineers).""

At"the"faculty"level,"we"continue"to"strive"for"increased"diversity"within"our"informatics" faculty."We"recognize"that"a"diverse"set"of"faculty"provide"role"models"and"mentorship"to"a" diverse"set"of"students.""

Evaluation"of"diversity"goals:""Our"diversity"goals"will"be"reviewed"at"least"annually"by"our"

9" Executive"Committee."These"reviews"will"include"detailed"reviews"of"our"applicant"pool,"our" admissions"processes,"our"retention"of"trainees"and"post.matriculation"outcomes"and"will" take"into"account"URM"status"to"ensure"we"are"adequately"supporting"our"diversity"goals."We" will"adjust"our"URM"identification,"recruitment"and"retention"strategies"and"our"assessments" of"barriers"that"URM"trainees"face"as"needed.""

F.! Interrelationship"of"the"program"with"the"University"of"California"institutions"(if"applicable):" UC"Davis"has"a"Health"Informatics"Master’s"degree"program" (http://www.ucdmc.ucdavis.edu/informatics/)."The"program"has"been"designed"to" efficiently"provide"training"in"health"informatics."The"program"delivers"advanced"training"in" informatics"to"professionals"who"want"to"redirect"their"careers"to"become"a"health" informatician,"as"well"as"those"who"are"interested"in"integrating"health"informatics"expertise" in"their"current"professional"roles."There"are"a"required"43"units"of"credit"to"complete"the" master’s"degree."Currently"10"students"are"enrolled"in"the"program."

G.! Administration"of"the"program:" The"Health"Informatics"MS"degree"will"be"administered"by"DBMI"(see"Table"3"for" management"roles)."The"administrator"will"be"provided"by"existing"DBMI"staff,"who"will"be" transitioning"part"of"their"time"off"of"completed"projects.""Administration"tasks"include" enrollment"and"registration,"student"advising,"administration"of"program,"international" student"issues,"visa"documentation"and"graduate"student"health"insurance."There"will"also"be" a"marketing"component"through"the"degree"website,"outreach"opportunities,"and" partnerships"with"related"degree"programs"to"recruit"students."SSPPS"will"collaborate"in"this" program"by"offering"resources,"office"space,"and"faculty"to"teach"program"courses."

H.! Plan"for"Evaluation"of"the"Program:" The"program"in"Health"Informatics"will"be"reviewed"annually"by"an"internal"management" committee."In"keeping"with"established"campus"procedures,"we"will"also"plan"an"internal" review"by"the"Executive"Committee,"the"Campus"Graduate"Council"and"the"Office"of" Graduate"Studies"and"Research"approximately"three"to"five"years"after"admitting"the"first" class"of"students."

Potential"reviewers:"

Internal:))

Michael)Hogarth,)MD,)Professor,)DBMI,)UCSD)::)[email protected])

External:)

) Alex)Bui,)PhD)(UC)Los)Angeles))::)[email protected]) 10" ) Ida)Sim,)PhD,)MD)(UC)San)Francisco))::)[email protected])

) Kai)Zheng,)PhD)(UC)Irvine))::)[email protected])

) Kathy)Kim,)PhD,)MPH,)MBA)(UC)Davis))::)[email protected])

) John)Luo,)MD)(UC)Riverside))::)[email protected])

) Jason)Lam,)PharmD)(Sharp)Healthcare))::)[email protected]" II.! Section'2.'Program' ! Admission"Requirements"(see"Appendix"I"for"the"admission"score"sheet):" •! Doctor"of"Medicine,"Doctor"of"Pharmacy,"Doctor"of"Veterinary"Medicine,"BS"Nursing," other"health.related"doctoral,"masters,"or"baccalaureate"degree"holders." o! Minimum"3.0"GPA"on"a"4.0"scale"(or"equivalent)"from"the"institution(s)"where" degree(s)"was"earned." o! Track"selection"will"determine"background"qualifications"for"the" candidate." •! Letters"of"recommendation"(3)" •! Personal"statement" •! TOEFL"Scores:" o! Applicants"whose"native"language"or"whose"academic"instruction"is/was"not" English"must"successfully"meet"the"following"TOEFL"requirements:" o! Internet.Based"(IBT)"—"minimum"score"100" o! Written"Test"—"minimum"score"600"or"250"for"the"computer.based"test" •! IELTS"Scores:" o! As"an"alternative"to"the"TOEFL,"students"may"submit"scores"from"the"Academic" Modules"of"the"International"English"Language"Testing"System"(IELTS)" designed"by"the"University"of"Cambridge"Local"Examinations"Syndicate"and" administered"by"the"British"Council"worldwide." o! The"minimum"band"score"required"for"admission"is"7"on"a"9.point"scale." o! IELTS"scores"expire"after"two"years."Scores"that"are"older"than"two"years"will" not"be"accepted." ! Foreign"Language"Requirements:" Foreign"language"proficiency"is"not"required."English"is"the"common"language"of"the" discipline."" ! Computational"/"Analytical"Requirements:" Health"informatics"is"a"multidisciplinary"field"and"we"anticipate"that"our"program"will" attract"candidates"with"a"wide"range"of"backgrounds.""Our"program"does"train"students"in" the"analytic"foundations"in"the"field"and"therefore,"we"require"some"introductory"education" in"programming"prior"to"enrollment.""For"those"students"without"satisfactory"completion"of" an"introductory"programming"course"on"a"transcript"within"the"past"5"years,"we"require"

11" completion"of"an"in.person"or"online"introduction"to"programming"prior"to"starting"our" program."

We"consider"a"diverse"set"of"backgrounds"to"be"a"strength"and"plan"to"capitalize"on"the"wide" range"of"expertise"in"our"students"by"emphasizing"team"projects"in"several"of"the"courses."" For"each"student,"a"mentor"will"assess"specific"strengths"and"needs"and"will"help"direct" individualized"supplemental"training"as"needed." " ! Program"of"Study:" Master’s"Plan"I"(with"thesis)"and/or"Plan"II"(with"comprehensive"examination)" Total"unit"requirements:"48"quarter"credits"(31"units"of"required"core"courses).""Either"option" can"be"taken"as"full.time"(at"least"12"units"per"quarter)"or"part.time."Required"and" recommended"courses"are"described"below"(see"Appendix"II"for"course"descriptions," Appendix"III"for"course"approval"requests,"Appendix"IV"for"the"anticipated"impact"of"new" courses"on"existing"UCSD"courses,"Table"2"for"elective"options,"and"Table"4"for"a"sample" program"of"study).""New"courses"created"for"this"program"will"be"made"available"to"students" enrolled"in"state.supported"programs"within"the"Schools"of"Medicine"and"Pharmacy:""" Core'Courses' (Core"Descriptions"are"provided"in"Appendix"II"and"a"Draft"Catalog"Copy"in"Appendix"V)" •! MED"264"Principles"of"Biomedical"Informatics"–"Existing"Course"(4"units)"Students" are"introduced"to"the"fundamental"principles"of"BMI"and"to"the"problems"that" define"modern"healthcare."The"extent"to"which"BMI"can"address"healthcare" problems"is"explored."Topics"covered"include"structuring"of"data,"computing"with" phenotypes,"integration"of"molecular,"image"and"other"non.traditional"data"types" into"electronic"medical"records,"clinical"decision"support"systems,"biomedical" ontologies,"data"and"communication"standards,"data"aggregation,"and"knowledge" discovery." " •! MED"267"Modeling"Clinical"Data"&"Knowledge"for"Computation"–"Existing"Course"(4" units)"This"course"describes"existing"methods"for"representing"and"communicating" biomedical"knowledge."The"course"describes"existing"health"care"standards"and" modeling"principles"required"for"implementing"data"standards,"including"biomedical" ontologies,"standardized"terminologies,"and"knowledge"resources." " •! Data"Science/Analytics"–"New"Course"(4"units)"Students"learn"how"to"extract" meaningful"knowledge"from"biomedical"datasets."The"course"describes"the"pipeline" from"acquiring"and"preparing"data"to"various"analytic"techniques."Students"get" practical"experience"with"widely.adopted"tools"and"will"focus"on"addressing"real. world"problems." " •! SPPS"219"Pharmacogenomics"–"Existing"Course"(2"units)"Health"care"professionals" will"need"to"interpret"genome.based"information"for"understanding"disease"and" optimizing"drug"therapy."Prior"knowledge"of"a"patient’s"genetic"composition"should" be"carefully"considered"with"the"intent"of"changing"the"approach"to" pharmacotherapy"and"outcome"for"the"patient."To"the"extent"possible,"this"course"is" designed"to"integrate"with"212B"Therapeutics"and"218B"Contemporary"Topics"in" Pharmacology."Applications"of"concepts"from"your"previous"pathophysiology,"

12" pharmaceutics,"pharmacokinetics,"and"pharmacology"courses"will"be"emphasized" where"applicable." " •! Scripting"and"Databases"–"New"Course"(4"units)"This"course"introduces"students"to" scripting"languages"and"databases,"as"they"are"applied"to"clinical"informatics."" Students"gain"practical"experience"with"languages"such"as"python,"Perl,"and"SQL."" This"course"will"also"describe"the"different"database"architectures"in"current"health" IT"environments." " •! Change"Management/Organizational"Change"–"New"Course"(4"units)"Students"learn" and"discuss"methods"to"lead"change"in"complex"organizations."Topics"include" leadership"models,"key"aspects"of"change"management,"and"techniques"for"project" management."A"particular"emphasis"is"placed"on"how"the"models"and"techniques" impact"implementation"of"clinical"information"systems"and"health"information" technology"tools." " •! MED"265"Informatics"in"Clinical"Environments"–Existing"Course"(4"units)"This" course"introduces"the"basics"of"healthcare"systems"and"clinical"information"needs" through"direct"observation"and"classroom"discussion."Students"are"introduced"to" medical"language,"disease"processes,"and"health"care"practices"to"provide"context" prior"to"direct"patient"observation"at"primary,"specialty,"emergency,"and"inpatient" sites"in"conjunction"with"clinical"faculty"affiliated"with"the"training"program." Students"examine"how"clinicians"use"history.taking,"physical"examination"and" diagnostic"testing"to"establish"diagnoses"and"prognoses."Medical"decision.making"is" introduced"in"the"context"of"available"informatics"tools"and"clinical"documentation" and"communication"processes."Post.observation"classroom"discussions"encourage" students"to"think"critically"of"the"processes"they"observed"and"formulate" hypotheses"about"how"informatics"solutions"can"modify"the"processes." " •! MED"268"Statistics"Concepts"for"Biomedical"Research"–"Existing"Course"(4"units)"This" course"introduces"statistics"methods"for"basic,"pre.clinical,"and"clinical"research." Topics"include"descriptive"statistics,"t.tests,"ANOVA,"linear"and"logistic"regression," survival"analysis,"power"and"sample"size,"non.parametric"methods,"and"factorial" experiment"design."Emphasis"is"on"applications"rather"than"theorems"and"proofs." Students"will"gain"the"ability"to"design"efficient"and"informative"basic"research"and" clinical"trials,"to"perform"statistical"analyses"using"the"R"statistics"software,"and"to" critique"statistical"results"in"published"biomedical"research." " •! SOMI"226"or"BIOM"219"Ethics"in"Scientific"Research"–"Existing"Courses"(1"unit)"This" course"engages"research"trainees"in"reading,"considering,"and"discussing"the" responsible"conduct"of"science." " Electives'E'All'elective'options'are'listed'in'Table'2." " ! Field"Examinations:""N/A" " ! Qualifying"examinations:""N/A" " ! Thesis:"

13" For"students"in"the"Plan"I"program,"a"thesis"based"on"the"student’s"research"must"be" written"and"reviewed"by"the"student’s"thesis"committee."It"will"then"be"submitted"as" described"in"the"university"requirements"(http://grad.ucsd.edu/progress/dissertation. thesis.html")."The"MS"committee"will"consist"of"three"faculty"members"with"at"least"two" being"from"the"Health"Informatics"degree"program." " ! Final"Examination:" For"students"in"the"Plan"II"program,"obtaining"a"minimum"score"on"a"comprehensive,"written" examination"will"be"required"to"graduate."This"examination"will"be"created"based"on"the" learning"objectives"from"the"core"courses." " ! Special"Circumstances:""N/A" " ! Relationship"to"Master"and"Doctoral"programs:" This"program"is"related"to"the"existing"Bioinformatics"and"Systems"Biology"(BISB)"with" specialization"in"Biomedical"Informatics"(BMI)"PhD"program"offered"by"the"UCSD" Department"of"Bioinformatics"and"Systems"Biology."Some"of"the"coursework"will"be" shared"but"this"degree"will"focus"on"a"practice.based"graduate"who"expects"to"apply" clinical"informatics"approaches"in"practice."We"expect"that"some"students"from"the"MS"will" decide"to"continue"their"education"and"get"a"PhD"at"UCSD"or"another"academic"institution." However,"other"than"sharing"courses"with"the"BMI"track"of"the"BISB"program,"we"do"not" anticipate"any"formal"integration"with"this"or"other"programs"on"campus.""Also,"we"do"not" anticipate"any"negative"impact"on"BISB"students"access"to"these"courses"as"these"courses" currently"have"sufficient"capacity"to"add"students."

The"program"is"also"related"to"the"Master"of"Advanced"Studies"(MAS)"in"Clinical"Research" (CLRE).""As"a"professional"health"informatics"degree,"the"focus"of"our"proposed"program"is" quite"different"from"that"of"the"CLRE"program.""We"do"not"anticipate"significant"competition" for"students"with"this"program.""We"currently"send"up"to"two"students"a"year"to"the"CLRE" program"through"our"Biomedical"Informatics"training"program.""These"students"would"likely" pursue"the"MS"in"Health"Informatics"instead,"but"only"comprise"a"very"small"proportion"of"the" CLRE"class."

! Grades"and"Units" •! Only"courses"in"which"the"student"is"assigned"grades"A,"B,"C,"D,"P,"or"S"are"counted"in" satisfaction"of"the"requirements"for"the"Master's"degree.""In"addition,"a"student"must" maintain"a"minimum"grade"point"average"(GPA)"of"3.0"in"all"courses"taken"after" admission"to"graduate"status."

14" •! The"maximum"number"of"research"units"which"may"be"used"in"satisfaction"of"the" degree"requirements"is"12.""

! Residence"and"Candidacy:" The"minimum"residence"required"is"three"quarters.""Residence"is"established"by"satisfactory" completion"of"six"units"per"quarter,"some"of"which"must"be"at"the"graduate"level.""

! Special"preparation"for"careers"in"teaching:"N/A" ! Sample"Program:" Health'Informatics'Plan'I:'Thesis' •! Core"Courses:"31"units"required."All"courses"must"be"taken"for"a"letter"grade." o! Principles"of"Biomedical"Informatics"(MED"264)"."4"units" o! Scripting"and"Databases"(New"Class)" o! Modeling"Clinical"Data"&"Knowledge"for"Computation"(MED"267)"."4"units" o! Change"Management/Organizational"Change"(New"Class)" o! Statistics"Concepts"for"Biomedical"Research"(MED"268)"."4"units" o! Informatics"in"Clinical"Environments"(MED"265)"."4"units" o! Data"Science/Analytics"(New"Class)" o! Pharmacogenomics"(SPPS"219)."2"units" o! Ethics"in"Scientific"Research"(BIOM"219)"."1"unit" •! Electives:"5"units."Choose"from"a"list"of"approved"courses"(Table"2)."These"courses" can"be"taken"for"a"letter"or"S/U"grade.""

•! Thesis:"12"units."(New"Class)"

Health'Informatics'Plan'II:'Comprehensive'Examination'' •! Core"Courses:"31"units"required."All"courses"must"be"taken"for"a"letter"grade." o! Principles"of"Biomedical"Informatics"(MED"264)"."4"units" o! Scripting"and"Databases"(New"Class)" o! Modeling"Clinical"Data"&"Knowledge"for"Computation"(MED"267)"."4"units" o! Informatics"in"Clinical"Environments"(MED"265)"–"4"units" o! Change"Management/Organizational"Change"(New"Class)" o! Statistics"Concepts"for"Biomedical"Research"(MED"268)"."4"units" o! Data"Science/Analytics"(New"Class)" o! Pharmacogenomics"(SPPS"219)."2"units" o! Ethics"in"Scientific"Research"(BIOM"219)"."1"unit" o! Electives:"17"units."Choose"from"a"list"of"approved"courses"(Table"2)."Up"to"9"units" of"electives"can"be"taken"for"a"S/U"grade.""

15" " Table'2.'Elective'Options' ' Course'Title" Course'#" Instructor"

Pharmacy"Informatics" SPPS"205" Nuno"Bandeira"

Current"Trends"in"Biomedical"Informatics" MED"262" Jejo"Koola"

Scale"Development"for"Behavioral"Health FPM"278 David"Strong'

Biological"Databases CSE"182 Vineet"Bafna"

Human"Disease SPPS"215 Lawrence"Hansen"

Project"Management:"Health"Services" MGT"173" Robert"Fuller"

Project"Management" MGT"450" Sanjiv"Erat"

Database"System"Implementation" CSE"232B" Alin"Deutsch"

Human.Computer"Interaction" COGS"126" James"Hollan"

Information"Visualization" COGS"220" James"Hollan"

Interaction"Design" COGS"120" Scott"Klemmer"

Research"Topics"in"Human.Computer"Interaction" CSE"216" Scott"Klemmer"

" As"the"program"matures,"new"electives"may"be"added"based"on"the"industry"needs"as"well"as" preparation"and"career"interests"of"admitted"students.""Any"such"courses"and"changes"to"the" program"plan"would"be"presented"to"the"Graduate"Council"for"review"and"approval"at"that"time." " ! Normative"time"from"matriculation"to"degree:"" Assuming"that"the"student"has"no"deficiencies"and"is"full.time,"the"normative"time"for" matriculation"is"12.24"months."" " Other)incentives)to)support)expeditious)times:to:degree:""As"a"professional"degree"program,"our" trainees"will"be"highly"motivated"to"complete"the"program"within"24"months"to"enter"or" return"to"the"workforce.""The"students"will"also"have"regular"progress"assessments"with"their" mentors"to"ensure"that"the"student"will"graduate"in"a"timely"manner." " ! Student"Recruitment" •! Marketing"will"be"done"at"local"colleges"and"universities"in"the"San"Diego"area"(UCSD," San"Diego"State"University,"Cal"State"San"Marcos),"as"well"as"regional"health"systems" for"interested"professional"staff,"particularly"in"the"Information"Sciences"/"IT" departments"(Scripps,"UCSD"Health,"Sharp,"Kaiser,"Palomar,"Rady"Children’s)."

16" •! The"expected"composition"of"the"applicant"pool"is"post.baccalaureate"students,"recent" graduates"from"schools"of"pharmacy,"public"health,"and"nursing,"and"working" healthcare"professionals,"both"in"the"health"IT"ranks"as"well"as"healthcare" management." •! The"UCSD"School"of"Pharmacy"is"a"collaborative"partner"on"this"proposal." •! We"are"planning"for"30"students"per"year"and"anticipate"there"is"pent.up"demand"for" this"program"in"the"San"Diego"area.""To"sustain"this"enrollment"level,"we"plan"to" transition"several"classes"to"online"format"to"support"enrollment"by"students"located" nationally"and"internationally."

" III.! Section"3:"Projected"Need' ! Target"student"population:" " The"target"student"population"for"this"program"includes"domestic"and"international"students" who"hold"a"Doctor"of"Medicine,"Doctor"of"Pharmacy,"Doctor"of"Veterinary"Medicine,"bachelor’s" degree"in"nursing,"and/or"other"health.related"doctoral,"master’s,"or"bachelor’s"degree.""We" anticipate"this"target"student"population"would"be"interested"in"informatics"careers"and" would"apply"for"this"program"due"to"its"focus"on"applying"clinical"informatics"approaches"in" practice.""More"reasons"for"the"student"demand"are"described"in"the"next"sub.section." ! Student"demand"for"the"program:" Health"informatics"is"in"rapid"growth"across"the"health"care"spectrum" (inpatient/outpatient/ED,"pharmacy,"nursing,"analytics),"thus"providing:" •! Many"job"openings"for"qualified"applicants" •! Government.incentivized"adoption"of"HIT" •! Desire"to"reap"the"quality"and"efficiency"gains"that"have"been"elusive" •! Need"to"help"integrate"into"existing"organizations/workflows" " ! Opportunities"for"placement"of"graduates/career"opportunities:" The"Bureau"of"Labor"Statistics"does"not"track"job"opportunities"at"the"level"of"informatics" trained"physicians,"nurses,"pharmacists,"etc."In"spite"of"that,"online"and"print"media" regularly"feature"recruitments"and"advertisements"for"physicians,"pharmacists,"and"other" health"care"providers"with"expertise"in"health"informatics.""It"is"anticipated"that"this"trend," in"conjunction"with"growth"of"EHRs"and"EHR.enabled"devices"will"facilitate"a"demand"for" more"informatics"trained"clinical"providers"to"assure"optimal"use"of"large"investments.""

Graduates"of"the"proposed"program"would"likely"pursue"careers"in:" •! Large"and"small"medical"centers/group"practices"

17" •! Academic"medical"centers."the"employment"is"projected"to"grow"26%"from" 2012.2022"(http://www.bls.gov/home.htm)" •! Federal"and"state"government"agencies" •! Community"pharmacy"corporate"providers"organizations"such"as"national"chains" •! Consulting"firms" •! Data"analytic"groups."Programmers/research"analysts."employment"is"expected"to" grow"25.27%"from"2012.2022"(http://www.bls.gov/home.htm)" •! Biotech"and"pharmaceutical"companies" " ! Importance"to"the"discipline:" •! Advancing"the"field"of"Health"Informatics"requires"programs"that"train"students"to" apply"current"best"practices"in"real"medical"environments,"while"simultaneously" exploring"novel"interventions,"analytic"techniques"and"biomedical"discoveries."UC" San"Diego"is"very"well.positioned"to"develop"the"next"generation"of"health" informatics"specialists."

•! This"master’s"program"serves"as"an"entry"for"candidates"to"obtain"training"in"the" area"of"healthcare"informatics"without"committing"to"a"lengthier"PhD"program"in" informatics."

! Ways"in"which"the"program"will"meet"the"needs"of"society:" •! Application"of"clinical"knowledge"to"provider"information"systems" •! Implementation"of"care"protocols" •! Development"of"systems"tools"to"improve"reliability"and"quality"of"care" •! Provide"a"center"with"a"comprehensive"EHR"&"data"analytic"infrastructure"to" support"development"of"new"informaticians"through"a"rich"educational"and" training"experience" •! Graduates"will"help"usher"in"an"era"of"biomedical"discovery,"improved"quality," safety"and"value"through"the"use"of"HIT" •! Growing"demand"for"applied"clinical"information"system"leaders:" o! Currently,"positions"are"difficult"to"fill"due"to"inadequate"supply"of"well. trained"professionals." o! Many"sites"are"hiring"clinical"informatics"pharmacists"due"to"the" growing"needs"and"roles"around"EHRs."

18" ! Relationship"of"the"program"to"research"and/or"professional"interests"of"the"faculty:" •! We"have"informatics"faculty"currently"pursuing"related"efforts"in"clinical" informatics"research,"implementation"and"evaluation:"

o! Lucila"Ohno.Machado*"(All"of"Us"."https://studypages.com/s/all.of.us. research.program.492324,"pSCANNER."http://pscanner.ucsd.edu,"UC"ReX." http://www.ucrex.org,'Strong"Heart"StudyEiDASH."" https://medschool.ucsd.edu/"som/dbmi/projects/Pages/Strong.Heart.aspx) o! Robert"El.Kareh"(Post.Handoff"Reports"of"Outcomes"2"(PHAROS2),"Chair," Clinical"Decision"Support"Oversight"Committee,"clinical"decision"support"to" improve"appropriateness"of"diagnostic"testing,"development"and"use"of" electronic"triggers"to"identify"potentially"avoidable"diagnostic"delays)"" o! Christopher"Longhurst*,"Chief"Information"Officer"and"Associate"Chief" Medical"Officer,"Quality,"UC"San"Diego"Health" o! James"Killeen"(health"information"exchange,"telehealth,"operational"work"at" the"UCSD"Medical"Center)" " o! Michael"Hogarth*,"Chief"Research"Information"Officer"at"UC"San"Diego" Health."" o! Jejo"Koola"(applied"predictive"modeling"for"patients"with"liver"disease," clinical"informatics"consult"service)" o! Tsung.Ting"Kuo"(applying"blockchain"methods"to"healthcare)"

*Elected"Fellow"of"the"American"College"of"Medical"Informatics" " •! In"addition,"we"have"close"collaborations"with"faculty"from"the"School"of" Pharmacy:" o! Nuno"Bandeira"(biostatistics,"research"develops"novel"mass"spectrometry" algorithms"for"the"discovery"and"characterization"of"novel"biomarker" proteins,"post."translational"modifications"and"protein.protein" interactions)" o! Joseph"Ma"(teaches"pharmacogenomics,"and"is"examining"methods"that" evaluate"drug.drug"interactions.)"" o! Charles"Daniels"(evaluated"the"role"of"technologies"in"medication"error" reduction"and"patient.pharmacist"interaction."His"team"is"also"examining" use"of"multihospital"data"in"the"drug"costs"and"improved"outcomes)"

! Program"Differentiation:"

19" •! Our"program"enables"students"to"take"advantage"of"a"unique"combination"of" features"that"other"local"and"national"programs"lack:""(1)"experienced"academic" faculty"in"Health"Informatics"across"a"wide"range"of"clinical"disciplines,"including" general"and"specialized"medical"and"pharmacy"backgrounds;"(2)"a"close"and" synergistic"relationship"between"academic"and"operational"informatics"groups" within"a"world.class"academic"medical"center;"and"(3)"relationships"with"and" proximity"to"a"leading"bio.tech"industry.""Other"programs"within"the"Southern" California"area"and"elsewhere"cannot"offer"students"exposure"to"all"of"these" important"opportunities.""For"example,"the"program"at"the"University"of"San"Diego" has"no"physician"or"pharmacist"informaticians"as"faculty,"which"significantly" limits"the"applicability"to"professionals"from"those"disciplines.""

•! Students"obtain"guidance"and"feedback"from"industry"leaders"to"ensure"that" valuable"and"marketable"skills"are"obtained"through"the"program" •! DBMI"closely"tied"to"academic"medical"center—access"to"real.world"data," workflows,"comprehensive"EHR" •! Access"to"clinical"data"sources"across"the"University"of"California—ability"to"scale" interventions"and"study"across"various"sites" •! Strong"Computer"Science,"Cognitive"Science,"Bioinformatics"programs"and"Rady" School"of"Management"(speakers)"for"productive"collaborations" •! West"Health,"CalIT2"each"provides"unique"opportunities"for"students" " IV.! Section'4.'Faculty' Table"3"lists"the"faculty"from"DBMI"and"SSPPS"who"will"be"participating"in"this"MS"program." MS"program"management"roles"are"included"in"parentheses.""We"anticipate"that"our"program" will"not"create"an"excessive"burden"on"our"faculty"and"will"not"negatively"impact"research"or" service"for"a"few"reasons.""First,"many"of"our"courses"are"already"ongoing"and"have"room"to" add"more"students"and/or"move"from"being"offered"every"other"year"to"every"year.""Second," based"on"experience"at"the"UC"Davis"informatics"program,"we"expect"that"the"majority"of" students"will"choose"the"comprehensive"examination"option"over"the"thesis"option"which"will" limit"the"requirement"for"faculty"service"on"thesis"committees.""Third,"for"those"students"who" choose"the"thesis"option,"we"will"align"the"thesis"topics"with"the"faculty"research"areas"to"lead" to"benefits"for"both"students"and"faculty.""We"have"very"few"state.funded"faculty,"so"we"do"not" anticipate"significant"impact"in"state.supported"teaching.""We"are"not"pursuing"additional" faculty"FTE"for"this"program."

20" Table'3.'Program'Faculty*'from'DBMI'and'SSPPS' DBMI"Members SSPPS"Faculty Clay,"Brian,"MD" Koola,"Jejo,"MD" Abagyan,"Ruben, Hollenbach,"Kathy," Clinical"Professor,"" Assistant"Professor," Ph.D. Ph.D. Medicine" Medicine CMIO Bandeira,"Nuno," Ma,"Joseph,"Pharm."D.," El.Kareh,"Robert,"MD," Longhurst," Ph.D. FCP MS,"MPH" Christopher,"MD,"MS" Associate"Professor," CIO,"Associate"CMO," Daniels,"Charles," Gilson,"Michael,"MD," Medicine"(Co. Quality,"Medicine" Ph.D." Ph.D." Director) Sitapati,"Amy,"MD," Ohno.Machado,"Lucila," Watanabe," " Professor,"Medicine," MD,"PhD" Jonathan," CMIO"for"Population" Professor,"Medicine" Pharm."D.,"M.S." Health" (Governing"Council" ' Ph.D.,"BCGP" Chair)" ' Killeen,"James,"MD" Hogarth,"Michael,"MD" *CV/Biosketches"for"program"faculty"are" Clinical"Professor," Clinical"Professor," provided"in"Appendix"X." Emergency"Medicine"" Medicine" " Kuo,"Tsung.Ting,"PhD" Nemati,"Shamim,"PhD" Assistant"Professor," Assistant"Professor," Medicine" Medicine""

DBMI"Staff:"Day," " Michele,"Ph.D.,""(Co. Director)"

" ! Faculty"Teaching"and"Advising" •! Faculty"teaching"ratio:"""Of"our"nine"core"courses,"two"(22%)"will"be"taught"by" ladder"rank"faculty." •! Faculty"workload:"6"of"18"(33%)"faculty"in"DBMI"and"2"of"7"(29%)"faculty"in" SSPPS"will"be"involved"in"teaching"in"the"proposed"program.""None"will"be" teaching"courses"above"their"state.supported"program"teaching"load." •! Faculty"overload:""None"of"the"courses"will"be"taught"by"faculty"overload"or" faculty"buy"out"of"other"course"commitments." •! New"Faculty:""The"program"will"not"require"hiring"of"new"faculty." "" ! Faculty"Advising" •! The"program"will"have"a"director"for"advising"students."""This"director"will"be"an" existing"faculty"member"and"will"receive"compensation"for"this"role."All"faculty" listed"from"DBMI"and"SSPPS"will"be"involved"in"advising"students"on" requirements"and"comprehensive"examinations"or"theses.""The"expected"ratio" is"between"2.3"student"advisees"per"faculty"member."

21" " V.! Section'5.'Courses Table"4"provides"a"sample"1.year"(full.time)"and"2.year"(part.time)" program"of"study." " Table'4.'Sample'Program'of'Study' ' Sample"Full.Time"Program*"' *''For"Comprehensive"Exam"option,"Thesis"units"would"be"replaced"by"additional"Electives" Count Course Units Faculty Q1:)Fall)Year)One 1 Principles"of"Biomedical"Informatics Required 4 Lucila"Ohno.Machado,"Professor," Chair,"UC"San"Diego"Health,"DBMI Statistics"Concepts"for"Biomedical" Michael"Walker,""Volunteer" 1 Required 4 Research Assistant"Professor"of"Medicine"&" Lucila"Ohno.Machado,"Professor," Chair,"UC"San"Diego"Health,"DBMI

Scripting"and"Databases" Nuno"Bandeira,"Associate" 1" Required" 4" Professor,"School"of"Pharmacy" Q2:)Winter)Year)One 1" Data"Science/Analytics" Required" 4" Shamim"Nemati,"Assistant" Professor,"DBMI" 1 Informatics"in"Clinical"Environments Required 4 Robert"El.Kareh,"Associate"Clinical" Professor,"DBMI"&"Amy"Sitapati," Clinical"Professor,"Medicine 1 Pharmacogenomics Required 2 Joseph"Ma,"Professor,"School"of" Pharmacy 1" Ethics"in"Public"Health"Research/Practice" Required" 1" TBD" 1" Current"Trends"in"Biomedical"Informatics" Elective" 1" Jejo"Koola,"Assistant"Clinical" Professor,"DBMI" Q3:)Spring)Year)One 1 Modeling"Clinical"Data"&"Knowledge"for" Required 4 Michael"Hogarth,"Clinical"Professor," Computation DBMI 1" Research"Topics"in"Human.Computer" Elective" 4" Scott"Klemmer,"Professor,"Cognitive" Interaction" Science"and"Computer"Science"&" Engineering" 1" Thesis" " 4" " Q4:)Summer)Year)One Change"Management/"Organizational" 1 Required 4 Robert"El.Kareh,"Associate"Clinical" Change Professor,"DBMI" 1 Thesis 8 ' Sample"Part.Time"Program*" *''For"Comprehensive"Exam"option,"Thesis"units"would"be"replaced"by"additional"Electives'

22" Count Course Units Faculty Q1:)Fall)Year)One 1 Principles"of"Biomedical"Informatics Required 4 Lucila"Ohno.Machado,"Professor," Chair,"UC"San"Diego"Health,"DBMI Scripting"and"Databases Nuno"Bandeira,"Associate" 1 Required 4 Professor,"School"of"Pharmacy Q2:)Winter)Year)One 1 Data"Science/Analytics Required 4 Shamim"Nemati,"Assistant" Professor,"DBMI 1 Informatics"in"Clinical"Environments Required 4 Robert"El.Kareh,"Associate"Clinical" Professor,"DBMI"&"Amy"Sitapati," Clinical"Professor,"Medicine 1 Pharmacogenomics Required 2 Joseph"Ma,"Professor,"School"of" Pharmacy Q3:)Spring)Year)One 1" Modeling"Clinical"Data"&"Knowledge"for" Required" 4" Hogarth,"Michael,"Clinical"Professor," Computation" DBMI" 1" Research"Topics"in"Human.Computer" Elective" 4" Scott"Klemmer,"Professor,"Cognitive" Interaction" Science"and"Computer"Science"&" Engineering" Q4:)Summer)Year)One Change"Management/"Organizational" Robert"El.Kareh,"Associate" 1 Required 4 Change Professor,"DBMI" Q5:)Fall)Year)Two Michael"Walker,""Volunteer" 1 Statistics"Concepts"for"Biomedical"Research Required 4 Assistant"Professor"of"Medicine&" Lucila"Ohno.Machado,"Professor," Chair,"UC"San"Diego"Health,"DBMI 1 Current"Trends"in"Biomedical"Informatics Elective 1 Jejo"Koola,"Assistant"Clinical" Professor,"DBMI Q6:)Winter)Year)Two 1 Ethics"in"Public"Health"Research/Practice Required 1 TBD 1" Thesis" " 6" " Q7:)Spring)Year)Two 1 Thesis 6 VI.! Section'6.'Resource'Requirements'(Estimated'for'the'first'5'years)'' ! FTE"faculty:" We"currently"have"faculty"to"serve"the"program"and"plan"to"engage"more"based"on"course" needs."Designated"committee"members"will"commit"time"and"effort"to"this"program."A" reduction"in"the"teaching"requirement"of"the"directors"will"be"requested"due"to"the" significant"responsibility"and"administrative"effort"required."We"will"be"recruiting"current" faculty,"new"faculty"and"industry"personnel"as"mentors"for"students."We"do"not"anticipate"

23" additional"costs"for"faculty."This"program"will"be"staffed"by"shifting"effort"from"independent" study"teaching"or"by"newly"appointed"faculty."""

! Library"acquisition:"No"new"resources"required." ! Computing"costs:" Our"plan"calls"for"two"computing"labs."Both"labs"are"existing"labs."One"is"located"in"DBMI" and"the"other"is"located"in"SSPPS."Both"labs"will"be"made"available"to"this"program"on"a"first" come"first"serve"basis."

! Equipment:"No"new"resources"required." ! Space"and"other"capital"facilities:" •! DBMI"is"located"on"the"top"floor"of"the"new"Biomedical"Research"Building"close"to" the"School"of"Medicine."The"space"has"17"offices,"22"cubicles,"a"meeting"room,"supply" room,"and"ample"waiting"areas,"totaling"circa"3,000"sq."ft."Added"to"1,500"sq."ft."from" our"nearby"space"(8"offices,"1"meeting"room,"and"8"cubicles),"and"additional"2"offices" at"the"Telemedicine"Building,"we"have"almost"5,000"sq."ft."of"space"for"the"research" and"training"components"of"DBMI"for"approximately"35"people."The"service" component"is"primarily"co.located"with"the"Altman"Clinical"and"Translational" Research"Institute,"which"has"a"building"housing"12"staff"members."

•! The"Skaggs"School"of"Pharmacy"and"Pharmaceutical"Sciences"proudly"opened"its" doors"in"January"2006."Built"as"the"first"phase"of"development"in"the"master"plan"for" future"construction"south"of"the"existing"School"of"Medicine"buildings,"the" pharmaceutical"sciences"building"provides"the"facilities"and"space"necessary"to" support"the"Skaggs"School"of"Pharmacy"and"Pharmaceutical"Sciences,"and"related" research."

•! The"space"consists"of"approximately"76,150"net"assignable"square"feet"(ASF)"in" several"major"program"elements."The"space"types"include:""

o! Wet"research"laboratory"space"

o! Dry"research"laboratory"space"

o! Shared"support"laboratory"space,"including"analytical"laboratories"

o! Faculty"offices"and"meeting"spaces"

o! Administrative"offices"

o! Classrooms"

24" o! Auditorium"

The"building"consists"of"four"floors"plus"a"basement."The"ground"level"is"home"to"five" lecture.style"classrooms,"two"of"which"seat"60"students"each,"and"all"of"which"are" equipped"with"state"of"the"art"AV."In"addition,"one"classroom"features"3D"projection" capability,"student.run"and"operated"podcasting"(exclusively"for"classroom"use),"and" a"capacity"for"teleconferencing."The"ground"level"is"also"home"to"a"clinical"simulation" lab"with"four"point.of.care"patient"rooms,"along"with"meeting"spaces"and" administrative"offices."The"second,"third"and"fourth"floors"contain"laboratories," meeting"spaces"and"faculty"and"staff"offices,"the"layout"of"each"being"a"mirror"image" of"the"others."The"different"types"of"research"laboratories"are"distributed"throughout" the"three"research"floors"to"promote"the"interaction"of"the"research"scientists."Upon" entrance"to"the"third"floor,"one"becomes"quickly"aware"that"something"unique"exists" here:"the"Protein"Data"Bank"(PDB),"administered"by"the"nonprofit"Research" Collaboratory"for"Structural"Bioinformatics."The"PDB"provides"an"essential"library"of" protein"and"nucleic"acid"structures"and"supports"research"worldwide."The"building's" basement"houses"the"Health"Sciences"Education"Center,"a"portion"of"which"was" funded"by"the"Skaggs"family."It"consists"of"a"260.seat"auditorium"with"state"of"the"art" AV;"three"break.out"rooms,"each"of"which"seats"50;"and"a"lovely"lobby"and"patio"area." In"addition"to"the"Health"Sciences"Education"Center,"the"basement"also"contains" laboratory"space"which"houses"an"NMR"magnetic"facility,"a"proteomics"laboratory" and"a"mass"spec"laboratory."All"three"laboratories"are"used"not"only"by"the"School"of" Pharmacy's"researchers,"but"also"by"researchers"from"across"the"UC"San"Diego" campus"and"from"the"Scripps"Institute"of"Oceanography."

The"Pharmaceutical"Sciences"Building"provides"state"of"the"art"facilities"for" pharmaceutical"research"and"instruction,"and"for"interface"with"other"universities" and"institutions."It"includes"computer"intensive"computational"research"and" instructional"spaces,"as"well"as"connection"to"the"San"Diego"Supercomputer"Center" located"on"campus."The"Skaggs"School"of"Pharmacy"and"Pharmaceutical"Sciences" proudly"welcomes"you." •! With"the"combined"space"and"facilities,"we"do"not"anticipate"additional"costs." These"locations"will"facilitate"student"interaction"with"medical"school" researchers"and"other"students"in"biomedical"informatics"and"mentoring"by"both" biomedical"informatics"and"pharmaceutical"sciences"faculty."

25" •! Office"space"will"be"provided"for"core"SPPSP"and"DBMI"faculty"listed"in"the" program." •! Courses"will"be"taught"in"existing"facilities.""Many"of"the"courses"are"currently" available"and"can"be"expanded"to"accommodate"students"in"the"proposed" program"without"significant"impact.""These"expansions"may"change"the"size"of"the" room"required,"but"should"not"have"significant"impact"on"the"scheduling"of"the" courses." •! We"anticipate"that"the"need"for"TAs"will"only"increase"very"slightly"since"many"of" the"courses"already"exist"and"the"current"TAs"could"support"larger"classes."" Between"DBMI"and"the"School"of"Pharmacy,"enough"graduate"students"exist"to" accommodate"the"small"increase"in"the"number"of"required"TAs."

! Other"Operating"costs" Although"this"program"will"be"self.supporting,"we"may"request"that"the"initial" development"costs"be"underwritten"from"first"contributions"to"the"campus."Please"see" Appendix"VI"for"the"budget"and"a"copy"of"the"review"by"Louie"Cruz,"principal"budget" analyst"from"UCSD"Campus"Budget"Office."Mr."Cruz"has"vetted"the"program"as"self. supporting."Included"in"Appendix"VI"is"a"letter"of"endorsement"from"David"Brenner,"Vice" Chancellor"for"Health"Sciences,"that"waives"the"Vice"Chancellor"tax"for"the"program’s"first" three"academic"years."

" VII.! Section'7.'Graduate'Student'Support' Our"resource"plan"includes"an"extensive"effort"to"identify"external"resources"in"support"of" graduate"students."Although"a"commitment"of"direct"support"for"all"MS"students"is"not" anticipated,"some"fellowship"support"is"likely."We"assume"that"much"of"the"support"for" students"will"come"in"the"form"of"financial"aid."We"also"have"a"plan"to"provide"two" academic"scholarships"per"year"for"selected"students"in"the"cohort.""These"scholarships" would"not"draw"on"funds"used"in"existing"programs"and"therefore"will"not"impact"other" existing"programs."""

" VIII.! Section'8.'Governance' The"Health"Informatics"Master’s"degree"program"will"be"governed"by"DBMI"under"the" Department"of"Medicine.""The"bylaws"for"the"program"have"been"created"to"outline"the" governance"processes.""These"bylaws"have"been"attached"to"the"proposal." IX.! Section'9.'Changes'in'Senate'Regulations' ' 26" None"Required" " " X.! Financial'Accessibility'and'Impact'on'StateESupported'Programs' " We"anticipate"that"our"return.to.aid"for"will"be"10%"of"the"program"tuition.""These"funds"will" be"used"for"a"small"number"of"need.based"scholarships.""The"bulk"of"financial"support"will"be" in"the"form"of"financial"aid." ' XI.! Impact'on'StateESupported'Programs' " We"do"not"anticipate"that"our"program"will"have"any"impact"on"existing"state.supported" programs.""The"students"who"will"enroll"in"our"program"will"from"a"pool"of"students"not"part" of"current"programs." ' XII.! Optional'Appendices' " Appendices"are"attached." " "

27" Health!Informatics!Graduate!Program!Bylaws! Administrative!Home:!Division!of!Biomedical!Informatics,!! Department!of!Medicine,!School!of!Medicine! Revised:!3/14/2019! Graduate!Council’s!Approval!Date:!pending! ! Article!I.!Objective! ! A.!Degree!offered:!The!Health!Informatics!Program!offers!a!Master!of!Science!in!Health! Informatics!(MSHI)!degree.!The!MSHI!is!a!professional!degree,!rather!than!an!academic! degree,!and!will!be!led!by!the!Department!of!Medicine!in!collaboration!with!the!School!of! Pharmacy!at!the!University!of!California,!San!Diego!campus.!The!MSHI!Program!is!a! departmentallyQbased!program!administratively!housed!in!the!Division!of!Biomedical! Informatics!in!the!Department!of!Medicine,!and!the!MSHI!degree!is!conferred!by!the! Regents!of!the!University!of!California!as!nominated!by!the!Graduate!Council.!! ! B.!Discipline:!Health!Informatics!is!the!interdisciplinary!study!of!the!design,!development,! adoption!and!application!of!information!technologyQbased!innovations!in!healthcare! services!delivery,!management!and!planning.! ! C.!Mission:!!Our!mission!is!to!develop!the!health!informatics!leaders!of!the!future!by! providing!a!highQquality!MSHI!degree!program!in!partnership!with!the!medicine,!pharmacy! and!informatics!communities.! ! Article!II.!Membership! ! A.!Criteria!for!Membership! ! 1.!Disciplinary!expertise,!research!area,!and!accomplishments:! The!MSHI!Program!faculty!consists!of!faculty!members!of!the!UC!San!Diego! campus!qualified!to!teach!candidates!for!the!MSHI!degree!by!virtue!of!their! expertise!in!at!least!one!of!the!core!health!informatics!disciplines!(applied!clinical! informatics!and!public!health!informatics)!or!related!areas.!! ! 2.!Active!Research!or!Innovation:!!Members!should!be!active!in!research!or! applied!innovations!in!their!specific!core!health!informatics!discipline!or!related! discipline.! ! 3.!Voting!Rights:!!All!active!members!are!eligible!to!vote.!Faculty!must!hold!an! appropriate!academic!title!as!(a)!a!member!of!the!Academic!Senate!of!the! University!of!California!(includes!Professors,!Lecturers!with!Security!of! employment,!Professors!in!Residence,!Professors!Emeritus/a,!and!Research! Professors),!(b)!Professors!of!a!Health!Sciences!Clinical!Series,!(c)!Adjunct! Professor,!(d)!Lecturer!(without!Security!of!Employment),!or!(e)!!Lecturer!Without! Salary.!Academic!staff!with!primary!appointments!as!Cooperative!Extension! Specialists!or!in!the!Professional!Research!Series!are!not!eligible!to!be!members! of!graduate!programs!unless!they!also!hold!an!appropriate!instructional!title! (normally!Lecturer!Without!Salary).!! ! 28" B.!Application!for!Membership! ! 1.!Application!Process:!!Potential!members!may!be!nominated!by!an!existing!! member!or!nominate!themselves.!The!names,!qualifications,!and!CVs!of!applicants! will!be!made!available!to!members!for!comment.!After!consideration!of!these! comments,!the!Executive!Committee!votes!to!approve!or!reject!the!application!for! membership.!! ! 2.!Anticipated!contributions!of!members:!!Members!must!be!willing!to! participate!in!the!following!areas:!!serving!as!a!member!of!an!administrative! committee,!service!as!a!student!advisor!or!practicumQsite!preceptor,!or!teaching! that!is!consistent!with!the!course!requirements!or!the!mission!of!the!program.!! ! C.!Emeritus!Status:!!Emeriti!are!eligible!to!remain!active!in!the!program,!with!attendant!! full!voting!rights,!by!continued!involvement!with!the!program!and!the!mission!of!the!! program.! ! D.!Review!of!Membership:!Membership!will!be!reviewed!on!a!threeQyear!cycle! by!the!Executive!Committee,!with!approximately!oneQthird!of!the!membership!reviewed! each!year.!Maintenance!of!membership!requires!contribution!in!at!least!one!of!the! following!areas!over!a!threeQyear!period:!! ! 1.!Active!role!in!the!administration!of!the!program!by!serving!on!at!least!one!program! administrative!committee! 2.!As!a!student!graduate!advisor!or!practicumQsite!preceptor! 3.!Providing!coursework!instruction!to!MSHI!students!through!program!courses!or! related!courses!in!other!academic!units,!including!independent!study!and!directed! research!courses.! ! Members!not!meeting!this!criterion!will!be!placed!on!probation!for!one!year,!during!! which!they!are!expected!to!meet!membership!criteria.!Members!failing!to!meet!! membership!criteria!during!the!probationary!year!will!not!have!their!membership!! renewed.!Members!wishing!to!relinquish!their!membership!may!do!so!by! communicating!their!intent!in!writing!to!the!Program!coQDirectors.! ! E.!Membership!Appeal!Process! ! Process!for!appealing!membership!denial:!!If!membership!or!renewal!of!membership! is!denied,!the!denied!applicant!may!request!consideration!by!program!members.!If!the! denied!application!for!membership!is!submitted!to!the!program!faculty!for!a!vote,!a!! majority!vote!of!the!total!program!faculty!membership!in!support!of!the!denied!candidate!! is!required!for!admission.!Applicants!denied!membership!or!renewal!of!membership!may! make!a!final!appeal!to!the!Dean!of!Graduate!Studies.! Article!III.!Administration! ! The!administration!of!the!program!and!its!activities!will!be!vested!in!an!Executive! Committee!consisting!of!at!least!six!program!members,!including!the!graduate!program! directors,!and!chaired!by!Lucila!OhnoQMachado.! !

29" Article!IV.!!Graduate!Program!Directors! !!! A.!Duties!of!the!Graduate!Program!Directors! ! Duties!of!the!Graduate!Program!Directors!include:!! a)!provide!overall!academic!leadership!for!the!program\!!! b)!develop!and!implement!policies!for!the!program\!!! c)!represent!the!interests!of!the!program!to!the!campus!and!university!administrators\!!! d)!call!and!preside!at!meetings!of!the!Executive!Committee\!!! e)!call!and!preside!at!meetings!of!the!program\!! f)! be!responsible!for!coordinating!all!administrative!matters!with!the!Graduate!Division\!! g)!manage!the!budgets!of!the!program\!! h)!submit!course!change!or!approval!forms\!! i)! be!responsible!for!the!accuracy!of!all!publications!related!to!the!program,!including!web! pages!and!catalog!copy\!! j)! coordinate!program’s!graduate!course!teaching!assignments!with!relevant!department! chairs\!! k)!nominate!graduate!advisors!for!appointment.! l)! establish!permanent!or!ad!hoc!committees!as!needed! ! Article!V.!Committees! ! Executive!Committee! ! 1.! MakeMup:!The!committee!includes!seven!members:!at!least!four!members! representing!DBMI,!at!least!one!member!representing!the!SSPPS,!at!least!one!MSHI! student,!and!at!least!one!member!from!other!campus!programs.! ! 2.! Appointment!of!members:!The!members!of!the!Executive!Committee!shall!be! elected!by!the!program!membership,!with!the!student!member!appointed!by!the!coQ Directors!after!consultation!with!the!students,!as!described!in!VI.! ! 3.! Committee!Chairs:!!The!Committee!Chair!is!the!chief!of!DBMI.! ! 4.! Term!of!membership:!Three!years,!renewable.! ! 5.! Voting!rights:!!All!committee!members!have!equal!voting!rights,!with!the!exception!of! students.! !!!! 6.! Role!and!function:!The!Executive!Committee!is!the!policyQmaking!body!of!the!MSHI! Program.!The!committee!shall!also!function!as!a!membership!committee.!!The! Executive!Committee!shall!meet!at!least!quarterly!(excluding!summer)\!additional! meetings!may!be!held!as!necessary,!or!upon!petition!of!at!least!five!members.!All! meetings!of!the!Executive!Committee!shall!be!announced!so!that!members!may! present!matters!requiring!Executive!Committee!or!Graduate!Program!attention.!!The! Executive!Committee!may!establish!permanent!or!ad!hoc!committees!as!dictated!by! needs!of!the!program.! ! Curriculum!Committee!

30" ! 1.!!MakeMup:!The!committee!includes!the!instructors!of!record!for!the!required!core! coursework!and!the!Program!coQDirectors.!!There!shall!be!at!least!two!members! representing!DBMI,!at!least!two!members!representing!SSPPS,!and!at!least!one!MSHI! student.!! ! 2.!!Appointment!of!members:!The!Executive!Committee!shall!appoint!members!of!the! Curriculum!Committee.! ! 3.! Committee!Chair:!!The!Chair!of!the!Curriculum!Committee!shall!be!elected!by!and! from!its!members.! ! 4.! Term!of!membership:!Three!years,!renewable.! ! 5.! Voting!rights:!!All!committee!members!have!equal!voting!rights,!with!the!exception!of! students.! !!!! 6.! Role!and!function:!The!Curriculum!Committee!reviews!teaching!evaluations,!syllabi! and!other!related!documents!in!the!context!of!the!Program’s!teaching!mission!and! accreditation!requirements,!such!as!assuring!that!programmatic!competencies!and! course!objectives!are!being!met.!It!also!recommends!curriculum!policy!to!the! Executive!Committee.!!The!Curriculum!Committee!shall!meet!at!least!quarterly! (excluding!summer)\!additional!meetings!may!be!held!as!necessary,!or!upon!petition! of!at!least!five!members!of!the!Program.! ! Admissions!and!Advancement!Committee!!! ! 1.! MakeMup:!The!Committee!includes!at!least!two!faculty!members!representing!DBMI! and!at!least!one!MSHI!student.!!! ! 2.! Appointment!of!members:!The!Executive!Committee!shall!appoint!members!of!the! Admissions!and!Advancement!Committee.!! ! 3.! Committee!Chair:!The!Chair!of!the!Admissions!and!Advancement!Committee!shall! be!elected!by!and!from!its!faculty!members.!! ! 4.! Term!of!membership:!Members!are!appointed!for!three!years,!with!renewable! appointments.!!! ! 5.! Voting!rights:!All!committee!members!have!equal!voting!rights,!with!the!exception!of! students,!who!are!nonQvoting.! ! 6.! Role!and!function:!The!Committee!reviews!applications!to!the!program!and!selects! those!to!be!recommended!for!admission.!!The!Committee!shall!meet!as!needed!to! review!applications,!develop!a!list!of!applicants!recommended!for!admission,!and! confirm!completion!of!program!requirements!for!graduating!students.!!The! Committee’s!list!of!applicants!recommended!for!admission!is!forwarded!directly!to!the! Program!coQDirectors!for!action.!!The!committee!will!also!review!applications!for!

31" waiver!of!graduation!requirements!and!potential!disciplinary!or!disqualification!actions! and!provide!a!recommendation!to!the!Program!coQDirectors!for!action.!! ! Community!Relations!and!Recruitment!Committee! ! 1.! MakeMup:!The!committee!includes!at!least!two!faculty!members!from!DBMI,!and!at! least!one!MSHI!student.! ! 2.! Appointment!of!members:!The!Executive!Committee!shall!appoint!members!of!the! Community!Relations!and!Recruitment!Committee.! ! 3.! Committee!Chair:!!The!Chair!of!the!Committee!shall!be!elected!by!and!from!its! faculty!members.! ! 4.! Term!of!membership:!Three!years,!renewable.! ! 5.! Voting!rights:!All!committee!members!have!equal!voting!rights,!with!the!exception!of! students,!who!are!nonQvoting.!! ! 6.! Role!and!function:!The!Community!Relations!and!Recruitment!Committee!is! responsible!for!program!promotion!and!student!recruitment!planning.!!The!Committee! shall!meet!at!least!quarterly!(excluding!summer).!!Additional!meetings!may!be!held!as! necessary,!or!upon!petition!of!at!least!five!members!of!the!Program.!!! ! ! Article!VI.!Student!Representatives! ! A.!Committee!Appointment!Process:!!The!Program!coQDirectors!will!consult!with!the!! students!regarding!membership!on!the!various!program!Committees.!!! ! B.!Committees!on!which!students!serve:!!Students!serve!on!the!following!committees:! ! 1.!!Executive!Committee! 2.!!Curriculum!Committee! 3.!!Admissions!and!Advancement!Committee! 4.!!Community!Relations!and!Recruitment!Committee! 5.!!Ad!hoc!committees!as!appointed!by!the!Program!coQDirectors! ! C.!Term!of!service!and!reappointment:!!Students!serve!for!a!term!of!one!year,!with!the! potential!for!reappointment.!! ! D.!Voting!Rights:!Students!are!nonQvoting!members!of!the!program!committees.!! ! E.!Attendance!at!annual!meetings!of!the!program:!!Student!representatives!may! attend!annual!meetings!of!the!program.!! ! F.!Student!recusal!from!selected!matters:!!The!Chair!of!any!committee!with!student!!

32" members!must!excuse!the!student!representatives!from!meetings!during!discussion!about! other!students,!personnel!actions!or!disciplinary!issues!relating!to!faculty,!during!rankings! of!existing!students!for!funding,!and!for!disciplinary!issues!related!to!students.!! ! Article!VII.!Graduate!Advisors! ! A.!Appointment!Process:!Graduate!Advisors!are!appointed!in!compliance!with!the! policies!and!procedures!of!the!Graduate!Council!and!the!Graduate!Division.!!Nominations! will!be!solicited!from!among!the!faculty.!!The!Program!coQDirectors!will!! forward!the!nominations!to!the!Graduate!Division,!who!will!make!formal!appointments!on! behalf!of!the!Graduate!Council.! ! B.!Number!of!Advisors:!There!shall!be!at!least!one!Graduate!Advisor!for!every!15!! students.!! ! C.!Term!of!Service:!The!term!of!service!is!three!years,!with!potential!renewal.! ! D.!Duties!of!the!Graduate!Advisors:!!The!Graduate!Advisors!are!expected!to!meet!with! their!students!at!least!on!a!quarterly!basis!to!assess!progress!and!plan!curricular!! choices.!!The!Graduate!Advisors!also!review!each!student’s!progress!toward!thesis,!if! applicable.! !!!!! Article!VIII.!Meetings! ! A.!Graduate!Program!Annual!Meeting:!The!program!shall!have!an!annual!meeting!of!! all!faculty!in!the!Spring.!! ! B.!Convoking!the!Annual!Meeting:!!The!Program!coQDirectors!convoke!the!annual! meeting.! ! C.!Petitioning!for!additional!meetings:!If!five!or!more!members!petition!for!additional!! meetings,!the!Program!coQDirectors!will!convoke!an!additional!meeting.! ! D.!Notification!of!meetings:!!Faculty!will!be!notified!of!the!annual!meeting!and!any!! additional!plenary!meetings!by!email!at!least!two!weeks!prior!to!the!meeting.! ! E.!Participation!for!faculty!away!from!campus:!!Faculty!away!from!campus!may!! attend!the!annual!meeting!by!teleconference!(or!other!appropriate!technology).!! ! Article!IX.!Quorum! ! A!quorum!is!a!majority!(50+%)!of!all!members!eligible!to!vote.!!Passage!of!substantive! business!requiring!a!vote!of!the!membership!as!a!whole!requires!at!least!an!affirmative!! Majority!vote!(50+%)!of!all!members!voting.!!Voting!may!be!by!email!or!written!ballot.!!At! least!oneQweek!response!time!is!required.! ! Article!X.!Amendments!! !

33" A.!Process!for!proposing!amendments!to!the!bylaws:!!Amendments!to!the!bylaws! may!be!proposed!by!a!majority!of!the!Executive!Committee,!or!in!writing!to!the!Chair!of! the!Executive!Committee!by!any!five!members.! ! B.!Amendments!will!be!circulated!to!faculty:!Information!on!proposed!amendments!! will!be!circulated!by!email!to!the!faculty.! ! C.!Vote!process,!including!time!period!to!distribute!and!quorum!for!the!amendment! to!pass:!!!Voting!on!amendments!to!the!bylaws!will!be!accepted!for!two!weeks!following! dissemination!of!the!proposed!text!of!the!amendment.!!A!quorum!of!the!eligible!faculty! must!vote,!and!amendments!will!pass!if!at!least!twoQthirds!of!the!voting!members!approve! the!amendment.! " "

34" Appendix(I:(MS(Health(Informatics(Admission(Score(Sheet( " " Candidate: Total"Points:"

Section(I( Section(IV( Grades!"Most"recent"GPA"from"a"recognized"institution!"Based"on"a"four"point"scale" CV/Resume!"Relevant"Education"and"Experience" Points( Candidate( Based"on"CV"and"Application" GPA(Scale Available Score Points( Candidate( DegreeI(select(one Available Score 3.71!4.00""(A!A+) 40 US"Medical"Degree 10 3.31!3.70""(A!) 35 Foreign"Medical"or"Science"Doctoral"Degree 8

3.01!3.30""(B+) 30 Relevant"US"Graduate"Degree 7

2.71!3.00""(B) 25 US"Bachelors"Degree"or"any"Graduate"Degree 5 2.31!2.70""(B!) 20 2.3"&"Below"(C+) 15 Clinical(Experience( Points( Candidate( select(if(applicable Available Score 3"+"years"direct"work 9 Total(Maximum 40 MD"program"or"<"3"years"direct"work 5

More"than"3"years"of"indirect"work 5 Section(II( Less"than"3"years"of"indirect"work 2 Letters1of1Recommendation1

Points( Candidate( Research/Informatics(Experience( Points( Candidate( Recommender(Criteria Available Score select(if(applicable Available Score

Confident"discussion"of"student"characteristics,"work," Up"to"15 3"+"years"as"a"PI 6 goals"and"achievements Less"than"3"years"as"a"PI 4 Relevant"and"responsible"title(s)"of"recommenders Up"to"5 Co!PI,"Sub"PI"or"Site"PI 4

Research"Administrator 2 Total(Maximum 20

Total(Maximum 25 Section(III( Personal1Statement1 Points( Candidate( Statement(Criteria Available Score Discussion"of"achievable"and"meaningful"professional" NOTE:(English"proficient"is"a"separate"requirement"for"admission." up"to"8 outcomes"from"the"program Individuals"for"whom"English"is"not"their"first"language"must"achieve"a" TOEFL"score"of"80"(online)"or"550"(paper)."The"score"may"be"waived"in" Discussion"of"program"goals,"specific"research"interests" up"to"7 lieu"of"a"personal"interview"or"successful"USMLE"score." and"need"for"program

Total(Maximum 15 !

Appendix(II:(Course(Descriptions( ( Core(Courses:( ( MED(264(Principles(of(Biomedical(Informatics(–(Existing(Course((4(units)( Students(are(introduced(to(the(fundamental(principles(of(BMI(and(to(the(problems(that(define( modern(healthcare.(The(extent(to(which(BMI(can(address(healthcare(problems(is(explored.(Topics( covered(include(structuring(of(data,(computing(with(phenotypes,(integration(of(molecular,(image( and(other(non?traditional(data(types(into(electronic(medical(records,(clinical(decision(support( systems,(biomedical(ontologies,(data(and(communication(standards,(data(aggregation,(and( knowledge(discovery.( ( MED(267(Modeling(Clinical(Data(&(Knowledge(for(Computation(–(Existing(Course(–((4(units)( This(course(describes(existing(methods(for(representing(and(communicating(biomedical( knowledge.(The(course(describes(existing(health(care(standards(and(modeling(principles(required( for(implementing(data(standards,(including(biomedical(ontologies,(standardized(terminologies,(and( knowledge(resources.( ( Data(Science(and(Analytics(–(New(Course((4(units)( Students(learn(how(to(extract(meaningful(knowledge(from(biomedical(datasets.(The(course( describes(the(pipeline(from(acquiring(and(preparing(data(to(various(analytic(techniques.(Students( get(practical(experience(with(widely?adopted(tools(and(will(focus(on(addressing(real?world( problems.( ( SPPS(219(Pharmacogenomics(–(Existing(Course(–((2(units)( Health(care(professionals(will(need(to(interpret(genome?based(information(for(understanding( disease(and(optimizing(drug(therapy.(Prior(knowledge(of(a(patient’s(genetic(composition(should(be( carefully(considered(with(the(intent(of(changing(the(approach(to(pharmacotherapy(and(outcome(for( the(patient.(To(the(extent(possible,(this(course(is(designed(to(integrate(with(212B(Therapeutics(and( 218B(Contemporary(Topics(in(Pharmacology.(Applications(of(concepts(from(your(previous( pathophysiology,(pharmaceutics,(pharmacokinetics,(and(pharmacology(courses(will(be(emphasized( where(applicable.( ( Scripting(and(Databases(–(New(Course(–((4(units)( This(course(introduces(students(to(scripting(languages(and(databases,(as(they(are(applied(to(clinical( informatics.((Students(gain(practical(experience(with(languages(such(as(python,(Perl,(and(SQL.((This( course(will(also(describe(the(different(database(architectures(in(current(health(IT(environments.( ( Change(Management/(Organizational(Change(–(New(Course((4(units)( Students(learn(and(discuss(methods(to(lead(change(in(complex(organizations.(Topics(include( leadership(models,(key(aspects(of(change(management,(and(techniques(for(project(management.(A( particular(emphasis(is(placed(on(how(the(models(and(techniques(impact(implementation(of(clinical( information(systems(and(health(information(technology(tools.( ( MED(265(Informatics(in(Clinical(Environments(–(Existing(Course((4(units)( This(course(focuses(on(how(biomedical(informatics(approaches(can(be(applied(to(make(clinical(care( safer,(more(effective(and(more(efficient.(Students(learn(how(the(care(team(uses(clinical(information( on(the(front?line(of(care(in(several(clinical(settings.(We(discuss(specific(information(needs,(touch(on( analytic(techniques(and(emphasize(informatics(applications.(Students(design(and(present(final( projects(outlining(potential(solutions(to(important(clinical(informatics(problems.(

MED(268(Statistics(Concepts(for(Biomedical(Research(–(Existing(Course((4(units)( This(course(introduces(statistics(methods(for(basic,(pre?clinical,(and(clinical(research.(Topics( include(descriptive(statistics,(t?tests,(ANOVA,(linear(and(logistic(regression,(survival(analysis,(power( and(sample(size,(non?parametric(methods,(and(factorial(experiment(design.(Emphasis(is(on( applications(rather(than(theorems(and(proofs.(Students(will(gain(the(ability(to(design(efficient(and( informative(basic(research(and(clinical(trials,(to(perform(statistical(analyses(using(the(R(statistics( software,(and(to(critique(statistical(results(in(published(biomedical(research.( ( SOMI(226(or(BIOM(219(Ethics(in(Scientific(Research(–(Existing(Courses((1(unit)(( This(course(engages(research(trainees(in(reading,(considering,(and(discussing(the(responsible( conduct(of(science.( ( ( ( ( ( ((

! !! Appendix(III:(Course(Approval(Forms( UNIVERSITY OF CALIFORNIA, SAN DIEGO REQUEST FOR COURSE APPROVAL

X New Course Reinstatement Deletion Renumbering: old number______Summer Session Only Effective Quarter Year Change In Course Nature of Change: Winter 2021

Subject & Number Units Title

MED- 4 Data Science and Analytics

Hours Per Week Lec Sem Dis Lab Studio Practicum PE Act Med Clerk Outside Prep Other (describe) Expected of Student ! If the course has multiple discussion or other sections, how should the grade reports be printed (check one)? X Single List of all students By Dis Section By Lab Section By Studio Section By Tut Section

Grading - Undergraduate Standard Grading (letter or P/NP) P/NP Only

Grading – Graduate and SOM Standard Option (Graduate) X S/U Permitted S/U Only H/P/F (SOM)

H/NH/P/F (SOM) P/F (SOM)

May be taken for credit _____1______time(s). If more than once, justify:

X Final Exam Given If not, explain:

COURSE DESCRIPTION (In concise catalog description style, 40 word limit) Students learn how to extract meaningful knowledge from biomedical datasets. The course describes the pipeline from acquiring and preparing data to various analytic techniques. Students get practical experience with widely!adopted tools and will focus on addressing real!world problems.

Prerequisites: ENFORCEMENT List prerequisites and other restrictions to be enforced by computer (see instructions).

Prerequisites that must be completed:

Co-requisites (must be concurrent):

Other restrictions:

Special course characteristics. Check all boxes that apply and see instructions for required explanations. Use of animals Use of computer resources IP Grading Cross listed with ______Conjoined with ______

Instructor and title:

Shamim Nemati, Assistant Professor JUSTIFICATION: No course of this nature is currently being offered.

______Chair, Electives Committee date

______Department Chair date Registrar date

APPROVALS – GRADUATE COURSE APPROVALS - UNDERGRADUATE COURSE

______Dean, School of Medicine date ______Council of Provosts date

______Dean of Graduate Studies date ______CEP Subcommittee on Courses date

______Graduate Council date

Extent of approval: Indefinite Summer Only Expires at the end of ______quarter, 20____

FO 2073 (REV. 12/11/08)

! UNIVERSITY OF CALIFORNIA, SAN DIEGO REQUEST FOR COURSE APPROVAL

X New Course Reinstatement Deletion Renumbering: old number______Summer Session Only Effective Quarter Year Change In Course Nature of Change: Fall 2020

Subject & Number Units Title

MED- 4 Scripting and Databases

Grading - Undergraduate Standard Grading (letter or P/NP) P/NP Only

Grading – Graduate and SOM Standard Option (Graduate) X S/U Permitted S/U Only H/P/F (SOM)

H/NH/P/F (SOM) P/F (SOM)

May be taken for credit _____1______time(s). If more than once, justify:

X Final Exam Given If not, explain:

COURSE DESCRIPTION (In concise catalog description style, 40 word limit) This course introduces students to scripting languages and databases, as they are applied to clinical informatics. Students gain practical experience with languages such as python, Perl, and SQL. This course will also describe the different database architectures in current health IT environments. Prerequisites: ENFORCEMENT List prerequisites and other restrictions to be enforced by computer (see instructions).

Prerequisites that must be completed:

Co-requisites (must be concurrent):

Other restrictions:

Instructor and title:

Nuno Bandeira, Associate Professor JUSTIFICATION: No course of this nature is currently being offered.

______Chair, Electives Committee date

______Department Chair date Registrar date

APPROVALS – GRADUATE COURSE APPROVALS - UNDERGRADUATE COURSE

______Dean, School of Medicine date ______Council of Provosts date

______Dean of Graduate Studies date ______CEP Subcommittee on Courses date

______Graduate Council date

Extent of approval: Indefinite Summer Only Expires at the end of ______quarter, 20____

! FO 2073 (REV. 12/11/08)

! UNIVERSITY OF CALIFORNIA, SAN DIEGO REQUEST FOR COURSE APPROVAL

X New Course Reinstatement Deletion Renumbering: old number______Summer Session Only Effective Quarter Year Change In Course Nature of Change: Summer 2021

Subject & Number Units Title

MED- 4 Change Management and Organizational Change

Grading - Undergraduate Standard Grading (letter or P/NP) P/NP Only

Grading – Graduate and SOM Standard Option (Graduate) X S/U Permitted S/U Only H/P/F (SOM)

H/NH/P/F (SOM) P/F (SOM)

May be taken for credit ______time(s). If more than once, justify:

X Final Exam Given If not, explain:

COURSE DESCRIPTION (In concise catalog description style, 40 word limit) Students learn and discuss methods to lead change in complex organizations. Topics include leadership models, key aspects of change management, and techniques for project management. A particular emphasis is placed on how the models and techniques impact implementation of clinical information systems and health information technology tools. Prerequisites: ENFORCEMENT List prerequisites and other restrictions to be enforced by computer (see instructions).

Prerequisites that must be completed:

Co-requisites (must be concurrent):

Other restrictions:

Instructor and title:

Robert El-Kareh, Associate Clinical Professor JUSTIFICATION: No course of this nature is currently being offered.

______Chair, Electives Committee date

______Department Chair date Registrar date

APPROVALS – GRADUATE COURSE APPROVALS - UNDERGRADUATE COURSE

______Dean, School of Medicine date ______Council of Provosts date

______Dean of Graduate Studies date ______CEP Subcommittee on Courses date

______Graduate Council date

Extent of approval: Indefinite Summer Only Expires at the end of ______quarter, 20____

! FO 2073 (REV. 12/11/08)

Appendix(IV:(Anticipated(Impact(of(New(courses(on(Existing(Courses(at(UCSD( ( o! Data(Science/AnalyticsT((New(Class)( •! The(audience(for(our(class(will(largely(have(clinical(backgrounds(and(will(not(enter(with( computer(science(training.(This(course(will(be(designed(to(introduce(these(clinical( students(to(the(fundamentals(of(data(science(and(analytics.(There(exists(a(course(on( data(mining(and(predictive(analytics(in(the(CSE(department((CSE(255),(but(we(expect( our(focus(to(be(quite(different(for(a(clinical(audience(and(therefore(do(not(expect( significant(impact(on(CSE(255.(UCSD(also(has(an(MAS(in(Data(Science(and(Engineering( (DSE)(with(several(focused(data(science(and(analytics(courses(geared(toward(an( intended(audience(of(“early(to(mid?career(data(scientists(who(are(on(a(technical( leadership(track(within(their(companies,(or(who(are(interested(in(expanding(their( knowledge(&(training(in(data(science.”(Our(course(will(provide(a(foundation(in(data( science(for(clinicians(looking(to(expand(into(health(informatics,(but(not(focus(their( careers(on(data(science(specifically.(Therefore,(we(do(not(anticipate(a(significant(impact( on(the(DSE(program.( ( Existing(courses(at(UCSD( ( CSE(255.(Data( Learning(methods(for(applications.(Content(may(include(data(preparation,( Mining(and( regression(and(classification(algorithms,(support(vector(machines,( Predictive(Analytics( random(forests,(class(imbalance,(overfitting,(decision(theory,( (4(units) recommender(systems(and(collaborative(filtering,(text(mining,(analyzing( social(networks(and(social(media,(protecting(privacy,(A/B(testing.( Recommended(preparation:(CSE(103(or(similar.(Prerequisites:(graduate( standing(or(consent(of(instructor. DSE(221.(Data( R,(an(open(source(software(project(with(an(extensive(library(of(freely( Analysis(Using(R( available(packages(and(the(capability(to(apply(most(modern(statistical( (4(units) methods,(has(emerged(as(a(leading(statistical(computing(environment.( This(course(will(focus(on(providing(fundamental(compute(skills(necessary( for(effective(data(analysis(and(machine(learning(tasks(by(applying(modern( statistical(methods(implemented(in(R.(The(course(covers(practical(issues( in(statistical(computing(including(data(preparation,(manipulation,( analysis(and(the(generation(of(analytical,(predictive(and(graphical(results.( Topics(in(statistical(data(analysis,(machine(learning(and(graphics( applications(will(be(provided(along(with(practical(working(examples.( Machine(learning(topics(are(introduced(as(needed(when(addressing(real( world(data(mining(case(studies. DSE(232.( This(course(will(introduce(practical(and(pragmatic(considerations(related( Performance( to(the(performance(of(big(data(solution(approaches,(cover(the( Measurement( fundamentals(of(computer(performance(measurement,(especially(as( (4(units) applied(to(database(and(big(data(systems,(and(provide(an(understanding( of(the(primary(determinants(of(performance(in(big(data(systems.(The

course(will(cover:(tools(and(techniques(for(performance(monitoring(and( performance(tuning;(the(role(of(benchmarking(and(how(to(interpret( benchmark(results(in(context;(how(to(read(query(plans(and(perform( optimizations(and(database(tuning;(behavior(of(schedulers(and(governors,( including(systems(like(YARN,(Mesos,(Fair(Scheduler,(FIFO,(HPC( schedulers;(performance(characteristics(of(data(analytics(operations;( practical(limits(to(performance(scaling;(and(recent(results(in(big(data( performance(and(ongoing(work(in(performance(optimizations. DSE(220.(Machine( This(course(provides(a(broad(introduction(to(the(practical(side(of( Learning((4(units) machine?learning(and(data(analysis.(The(topics(covered(in(this(class( include(topics(in(supervised(learning,(such(as(k?nearest(neighbor( classifiers,(decision(trees,(boosting(and(perceptrons,(and(topics(in( unsupervised(learning,(such(as(k?means,(PCA(and(Gaussian(mixture( models. DSE(230.(Data( Map?reduce,(streaming(analysis,(and(external(memory(algorithms(and( Analysis(Using( their(implementation(using(the(Hadoop(and(its(eco?system:(HBase,(Hive,( Hadoop,(and(Spark( Pig(and(Spark.(The(class(will(include(assignment(of(analyzing(large( (4(units) existing(databases. DSE(290.(Case( Case(studies(discussed(by(speakers(from(industry,(government(and( Studies(in(Data( academia(expose(students(to(the(needs(and(uses(of(different(technologies( Science((2(units) and(their(roles(in(model(building. DSE(260.(Data A(team(design(project(in(the(final(two(quarters(of(the(program(culminates Science(Capstone in(a(final(report(and(an(oral(presentation(of(the(capstone(project.(In Design(Project addition,(there(might(be(a(demonstration(of(the(working(prototype.(The (2(units) project(will(start(by(identifying(a(domain(of(interest(and(the(available(data sources(that(will(be(used(to(study(the(domain.(From(this(starting(point there(will(be(two(parallel(and(interdependent(lines(of(work:(data extraction,(Transformation(and(Loading((ETL),(and(statistical(analysis(and model(building.(The(ultimate(goal(will(be(to(present(a(processing(pipeline which(transforms(the(raw(data(into(more(usable(forms(and(models(which separates(between(the(predictable(and(the(unpredictable(aspects(of(the underlying(system. ( o! Scripting(and(DatabasesT((New(Class)( •! This(new(course(will(teach(students(with(a(clinical(background(about(scripting( languages((e.g.,(python)(and(databases(and(their(specific(applications(to(health(care.((It( is(intended(for(those(without(computer(science(or(data(science(backgrounds(and(will(be( significantly(different(from(existing(courses(in(Computer(Science(and(Engineering((CSE()( or(Data(Science(and(Engineering((DSE).(We(expect(any(impact(of(our(new(course(on(the( existing(DSE(graduate(courses((DSE(200??(Python(for(Data(Analysis,(DSE(201??SQL( Database(Management(Systems(and(DSE(210??Statistics(and(Probability(Using(Python)( to(be(minimal(and(that(there(will(be(no(impact(on(the(existing(CSE(undergraduate( courses((CSE(135??Server?side(Web(Applications(and(CSE(132A??Database(System( Principles).(

( Existing(courses(at(UCSD( ( CSE(135.(Server?side( Design(and(implementation(of(dynamic(web?based(applications.(Multitier( Web(Applications( architecture,(scripting(languages,(SQL,(XML,(session(handling,(nonbrowser( (4(units) clients,(web(services,(and(scalability,(security,(and(usability(in(the(web( context.(Credit(is(not(offered(for(both(CSE(135(and(CSE(134A.( Prerequisites:(CSE(100(or(Math(176. CSE(132A.(Database( Basic(concepts(of(databases,(including(data(modeling,(relational( System(Principles( databases,(query(languages,(optimization,(dependencies,(schema(design,( (4(units) and(concurrency(control.(Exposure(to(one(or(several(commercial(database( systems.(Advanced(topics(such(as(deductive(and(object?oriented( databases,(time(allowing.(Prerequisites:(CSE(100(or(Math(176. DSE(200.(Python(for( The(goal(of(this(course(is(to(bring(students(with(diverse(background(and( Data(Analysis( experience(to(a(common(level(of(competency(in(programming(in(the( (4(units) context(of(complex(and(noisy(data.(Solid(competency(in(Python( programming(provides(its(owner(with(autonomy(and(independence(in( their(work.(Introduction(to(object(oriented(programming(using(python.( Regular(expressions.(Numpy(and(Numerical(Processing.(Ipython(and( Plotting.(Data(analysis(using(PANDAS.(Webpage(scraping(using(Scrapy.( The(Twitter(API.(NLTK. DSE(201.(SQL( This(course(will(provide(an(introduction(to(the(management(of(structured( Database( data(beginning(with(an(introduction(to(database(models(including( Management( relational,(hierarchical,(and(network(approaches.(It(will(also(cover(topics( Systems((4(units) in(database(system(implementation(including(query(languages(and(system( architectures;(parallel,(column?oriented,(and(array?based(database( systems;(advanced(SQL(features(including(user?defined(functions((UDFs),( triggers,(statistical(functions;(and(support(for(spatial(data. DSE(210.(Statistics( The(goal(of(this(course(is(to(give(the(student(a(foundation(in(probability( and(Probability( and(statistics.(Probability(and(statistics,(using(Python.(Distribution(over( Using(Python( the(real(line;(independence,(expectation,(variance,(correlation.(Central( (4(units) limit(theorem.(Chernoff/hoeffding(bound.(Statistical(tests.(The(Bonferroni( correction.(Book:(“Think(Stats:(Probability(and(Statistics(for( Programmers”(by(Allen(Downey. (

o! Change(Management/Organizational(ChangeT((New(Class)( •! The(proposed(course(in(change(management/organizational(change(will(provide( students(with(theoretical(frameworks(and(principles(to(lead(changes(in(organizations( with(respect(to(health(informatics.(The(Rady(School(of(Management(currently(has(a( course(on(Business(and(Organizational(Leadership((MGT(164)(that(does(not(focus(on( health(care(specifically.(The(MAS(program(in(Leadership(in(Health(Care(Organizations( has(a(course(in(Strategic(Management(and(Organizational(Change((LHCO(202),(which(is( available(only(to(those(enrolled(in(that(particular(program.(We(do(not(expect(that(our(

new(course(would(affect(either(of(these(existing(courses(as(their(students(appear(to( come(directly(from(their(own(programs.( ( Existing(courses(at(UCSD( ( MGT(164.( Students(will(study(alternative(organizational(structures,(their( Business(and( stakeholders(and(corporate(cultures,(and(their(use(in(meeting(strategic( Organizational( enterprise(priorities(facing(a(company.(This(course(provides(students( Leadership( with(insights(into(motivational(factors,(communications(networks,( (4(units) organizational(cultures,(and(alternative(leadership(styles.(The(concept(of( change(management(and(its(challenges(is(also(studied(along(with(power( and(influence.(Course(previously(listed(as:(Organizational(Leadership.( Prerequisites:(upper?division(standing. LHCO(202. This(course(examines(principles(and(applications(of(strategic Strategic management(and(the(change(management(concepts(necessary(to Management(and effectively(apply(these(principles(in(healthcare(organizations.(The Organizational course(provides(a(structured,(stepwise(approach(to(the(strategic Change((4(units) management(process(and(includes(methods(for(assessing(key(features(of (closed(course) organizational(environments(and(competitive(situations,(approaches(for developing(strategic(plans,(and(processes(for(insuring(the(successful implementation(of(strategy.(Prerequisites:(admission(to(the(MAS(in(the Leadership(of(Healthcare(Organizations(Program(or(consent(of department. ( Existing(courses(in(Health(Informatics(MS( o! All(of(the(courses(in(the(Health(Informatics(MS(that(already(exist(can(be(expanded(as(needed(to( accommodate(additional(students.(This(expansion(may(involve(increases(in(class(size(or( additional(instances(of(the(course(as(needed.( o! Principles(of(Biomedical(Informatics((MED(264)(?(4(units( o! Modeling(Clinical(Data(&(Knowledge(for(Computation((MED(267)?(4(units( o! Statistics(Concepts(for(Biomedical(Research((MED(268)?(4(units( o! Informatics(in(Clinical(Environments((MED(265)?(4(units( o! Pharmacy(Informatics((SPPS(205)?(2(units( o! Current(Trends(in(Biomedical(Informatics((MED(262)?(1(unit( o! Ethics(in(Scientific(Research((BIOM(219)?(1(unit( ( (

Appendix(V:(Draft(Catalog(Copy( Master!of!Science!in!Health!Informatics! [!graduate!program!|!courses!|!faculty!]!

PROGRAM!COADIRECTORS:!! Michele!Day,!PhD!

Robert!ElAKareh,!MD!

STUDENT!AFFAIRS:!(858)!534A8469! eAmail!TBD! All#courses,#faculty#listings,#and#curricular#and#degree#requirements#described#herein#are# subject#to#change#or#deletion#without#notice.!

Program!Focus!

The!Master!of!Science!(MS)!Program!in!Health!Informatics!will!be!a!one!to!two!!year!program! providing!graduate!training!that!prepares!students!in!the!application!of!biomedical!informatics!to! clinical!systems,!across!the!health!care!sector.!The!program!combines!theory!with!focused! applications!likely!to!impact!health!and!welfare!of!the!public!at!multiple!levels!and!will!be! conducted!with!a!30!student!cohort!

Participating!Departments! Division!of!Biomedical!Informatics!(DBMI)!School!of!Medicine!and!the!Skaggs!School!of! Pharmacy!and!Pharmaceutical!Science!(SPPS).!! !

•! School!of!Medicine!

•! Department!of!Medicine:!Division!of!Biomedical!Informatics!

•! Skaggs!School!of!Pharmacy!and!Pharmaceutical!Sciences!

Admissions!Requirements!

! Admission!Requirements!!

•! Doctor!of!Medicine,!Doctor!of!Pharmacy,!Doctor!of!Veterinary!Medicine,!BS! Nursing,!other!healthArelated!doctoral,!masters,!or!baccalaureate!degree! holders.!

o! Minimum!3.0!GPA!on!a!4.0!scale!(or!equivalent)!from!the! institution(s)!where!degree(s)!was!earned.!

o! Track!selection!will!determine!background!qualifications!for! the!candidate.!

•! Letters!of!recommendation!(3)!

•! Personal!statement!

•! TOEFL!Scores:!

o! Applicants!whose!native!language!or!whose!academic!instruction! is/was!not!English!must!successfully!meet!the!following!TOEFL! requirements:!

o! InternetABased!(IBT)!—!minimum!score!100!

o! Written!Test!—!minimum!score!600!or!250!for!the!computerAbased! test!

•! IELTS!Scores:!

o! As!an!alternative!to!the!TOEFL,!students!may!submit!scores!from! the!Academic!Modules!of!the!International!English!Language! Testing!System!(IELTS)!designed!by!the!University!of!Cambridge! Local!Examinations!Syndicate!and!administered!by!the!British! Council!worldwide.!

o! The!minimum!band!score!required!for!admission!is!7!on!a!9Apoint! scale.!

o! IELTS!scores!expire!after!two!years.!Scores!that!are!older!than!two! years!will!not!be!accepted.!

! Foreign!Language!Requirements:!

•! Foreign!language!proficiency!is!not!required.!English!is!the!common! language!of!the!discipline.!!

! ! For!further!admission!information,!students!should!see!the!Admissions!FAQ!on!our! website!(insert)!or!contact!the!graduate!coordinator!via!email!at!(insert!email)!or!at!(insert! phone!number).!

Curriculum!

Master’s!I!(with!thesis)!or!II!(with!comprehensive!exam)! Total!unit!requirements:!48!quarter!credits!(31!units!of!required!core!courses).!See!Appendix!II! for!course!descriptions,!Appendix!III!for!course!approval!requests,!Appendix!IV!for!the! anticipated!impact!of!new!courses!on!existing!UCSD!courses,!Table!2!for!elective!options,!and! Table!4!for!a!sample!program!of!study.!!! ! Core!Courses!! MED:264!Principles!of!Biomedical!Informatics!–!Existing!Course!(4!units)!Students!are! introduced!to!the!fundamental!principles!of!BMI!and!to!the!problems!that!define!modern! healthcare.!The!extent!to!which!BMI!can!address!healthcare!problems!is!explored.!Topics! covered!include!structuring!of!data,!computing!with!phenotypes,!integration!of!molecular,! image!and!other!non!traditional!data!types!into!electronic!medical!records,!clinical!decision! support!systems,!biomedical!ontologies,!data!and!communication!standards,!data!aggregation,! and!knowledge!discovery.! ! MED:267!Modeling!Clinical!Data!&!Knowledge!for!Computation!–!Existing!Course!(4!units)! This!course!describes!existing!methods!for!representing!and!communicating!biomedical! knowledge.!The!course!describes!existing!health!care!standards!and!modeling!principles! required!for!implementing!data!standards,!including!biomedical!ontologies,!standardized! terminologies,!and!knowledge!resources.! ! Data!Science/Analytics!–!New!Course!(4!units)!Students!learn!how!to!extract!meaningful! knowledge!from!biomedical!datasets.!The!course!describes!the!pipeline!from!acquiring!and! preparing!data!to!various!analytic!techniques.!Students!get!practical!experience!with!widely! adopted!tools!and!will!focus!on!addressing!real!world!problems.! ! SPPS:219!Pharmacogenomics!–!Existing!Course!(2!units)!Health!care!professionals!will!need! to!interpret!genome!based!information!for!understanding!disease!and!optimizing!drug!therapy.! Prior!knowledge!of!a!patient’s!genetic!composition!should!be!carefully!considered!with!the!intent! of!changing!the!approach!to!pharmacotherapy!and!outcome!for!the!patient.!To!the!extent! possible,!this!course!is!designed!to!integrate!with!212B!Therapeutics!and!218B!Contemporary! Topics!in!Pharmacology.!Applications!of!concepts!from!your!previous!pathophysiology,! pharmaceutics,!pharmacokinetics,!and!pharmacology!courses!will!be!emphasized!where! applicable.! ! Scripting!and!Databases!–!New!Course!(4!units)!This!course!introduces!students!to!scripting! languages!and!databases,!as!they!are!applied!to!clinical!informatics.!!Students!gain!practical! experience!with!languages!such!as!python,!perl,!and!SQL.!!This!course!will!also!describe!the! different!database!architectures!in!current!health!IT!environments.! ! Change!Management/Organizational!Change!–!New!Course!(4!units)!Students!learn!and! discuss!methods!to!lead!change!in!complex!organizations.!Topics!include!leadership!models,! key!aspects!of!change!management,!and!techniques!for!project!management.!A!particular! emphasis!is!placed!on!how!the!models!and!techniques!impact!implementation!of!clinical! information!systems!and!health!information!technology!tools.! ! MED:265!Informatics!in!Clinical!Environments!–!Existing!Course!(4!units)!This!course! introduces!the!basics!of!healthcare!systems!and!clinical!information!needs!through!direct! observation!and!classroom!discussion.!Students!are!introduced!to!medical!language,!disease!

processes,!and!health!care!practices!to!provide!context!prior!to!direct!patient!observation!at! primary,!specialty,!emergency,!and!inpatient!sites!in!conjunction!with!clinical!faculty!affiliated!with! the!training!program.!Students!examine!how!clinicians!use!historyAtaking,!physical!examination! and!diagnostic!testing!to!establish!diagnoses!and!prognoses.!Medical!decisionAmaking!is! introduced!in!the!context!of!available!informatics!tools!and!clinical!documentation!and! communication!processes.!PostAobservation!classroom!discussions!encourage!students!to!think! critically!of!the!processes!they!observed!and!formulate!hypotheses!about!how!informatics! solutions!can!modify!the!processes.! ! MED:268!Statistics!Concepts!for!Biomedical!Research!–!Existing!Course!(4!units)!This! course!introduces!statistics!methods!for!basic,!pre!clinical,!and!clinical!research.!Topics!include! descriptive!statistics,!t!tests,!ANOVA,!linear!and!logistic!regression,!survival!analysis,!power!and! sample!size,!non!parametric!methods,!and!factorial!experiment!design.!Emphasis!is!on! applications!rather!than!theorems!and!proofs.!Students!will!gain!the!ability!to!design!efficient!and! informative!basic!research!and!clinical!trials,!to!perform!statistical!analyses!using!the!R!statistics! software,!and!to!critique!statistical!results!in!published!biomedical!research.! ! SOMI!226!or!BIOM!219!Ethics!in!Scientific!Research!–!Existing!Courses!(1!unit)!This!course! engages!research!trainees!in!reading,!considering,!and!discussing!the!responsible!conduct!of! science.! ! ! Electives!:!All!elective!options!are!listed!in!Table!2.!

! (For!Master’s!I!only)!A!thesis!based!on!the!student’s!research!must!be!written!and!reviewed! by!the!student’s!thesis!committee.!It!will!then!be!submitted!as!described!in!the!university! requirements!(http://grad.ucsd.edu/progress/dissertationAthesis.html!).!The!MS!committee!will! consist!of!three!faculty!members!with!at!least!two!being!from!the!Health!Informatics!degree! program.!

(For!Master’s!II!only)!Students!will!take!an!additional!21!units!of!electives!and!a! comprehensive!exam.! ! ! Grades!and!Units! •! Only!courses!in!which!the!student!is!assigned!grades!A,!B,!C,!D,!P,!or!S!are!counted!in! satisfaction!of!the!requirements!for!the!Master's!degree.!!In!addition,!a!student!must!maintain!a! minimum!grade!point!average!(GPA)!of!3.0!in!all!courses!taken!after!admission!to!graduate! status.!

•! The!maximum!number!of!research!units!which!may!be!used!in!satisfaction!of!the!degree! requirements!is!12.!!

Residence!and!Candidacy:!

The!minimum!residence!required!is!three!quarters.!!Residence!is!established!by!satisfactory! completion!of!six!units!per!quarter,!some!of!which!must!be!at!the!graduate!level.!!

! Sample!Program:! Health!Informatics!Plan!I:!Thesis!

•! Core!Courses:!31!units!required.!All!courses!must!be!taken!for!a!letter!grade.!

o! Principles!of!Biomedical!Informatics!(MED!264)!!!4!units! o! Scripting!and!Databases!(New!Class)! o! Modeling!Clinical!Data!&!Knowledge!for!Computation!(MED!267)!!!4! units! o! Change!Management/Organizational!Change!(New!Class)! o! Statistics!Concepts!for!Biomedical!Research!(MED!268)!!!4!units! o! Informatics!in!Clinical!Environments!(MED!265)!!!4!units! o! Data!Science/Analytics!(New!Class)! o! Pharmacogenomics!(SPPS!219)!!2!units! o! Ethics!in!Scientific!Research!(BIOM!219)!!!1!unit!

•! Electives:!5!units.!Choose!from!a!list!of!approved!courses!(listed!in!Table!2).! These!courses!can!be!taken!for!a!letter!or!S/U!grade.!!

•! Thesis:!12!units.!(New!Class)!

! Health!Informatics!Plan!II:!Comprehensive!Exam!

•! Core!Courses:!31!units!required.!All!courses!must!be!taken!for!a!letter!grade.!

o! Principles!of!Biomedical!Informatics!(MED!264)!!!4!units!

o! Scripting!and!Databases!(New!Class)!

o! Modeling!Clinical!Data!&!Knowledge!for!Computation!(MED!267)!!!4! units!

o! Change!Management/Organizational!Change!(New!Class)!

o! Statistics!Concepts!for!Biomedical!Research!(MED!268)!!!4!units!

o! Informatics!in!Clinical!Environments!(MED!26)!!!4!units!

o! Data!Science/Analytics!(New!Class)!

o! Pharmacogenomics!(SPPS!219)!!!2!units!

o! Ethics!in!Scientific!Research!(BIOM!219)!!!1!unit!

o! Electives:!17!units.!Choose!from!a!list!of!approved!courses!(listed!in!Table! 2).!These!courses!can!be!taken!for!a!letter!or!S/U!grade.!!

o! Comprehensive!Exam:!The!student!must!secure!at!least!a!Master’s! level!pass!in!the!MS!Comprehensive!Exam.!

Further!Information! For!further!information!please!visit!our!website!at!(insert),!or!contact!the!(insert! information,!name,!email!and!phone)!

( ( ( (

Appendix(VI:(Budget,(Chancellor(and(VC(letters,(and(Campus(Budget(Office(Reviews( (

MS Degree in Health Informatics

Year 1 Year 2 Year 3 Steady State Comments

Revenue Buildup Student FTE Cohort 1 15 13 Assume 2 FTE withdraw or drop in their 2nd year Cohort 2 20 18 Assume 10% FTE withdraw or drop in their 2nd year Cohort 3 - - 30 27 Assume 10% FTE withdraw or drop in their 2nd year Cohort 4 - - - 30 Total (FTE) Students: 15 33 48 57 Units Taken per Cohort Cohort 1 34 14 Cohort 2 34 14 Cohort 3 34 14 Cohort 4 34 Per Unit Fee $1,000 $1,000 $1,000 $1,000 SSP degree programs can only charge one fee for all student types.

Total Tuition Revenue Generated 510,000 862,000 1,272,000 1,398,000 Financial Aid/Diversity Set-Aside 51,000 86,200 127,200 139,800 10% financial aid / diversity set-aside A Net Tuition Revenue Generated 459,000 775,800 1,144,800 1,258,200 Eligible for Assessments

Expense Breakdown

B Instruction 144,720 159,720 159,720 159,720 Benefit rates: 10% on faculty & 6% on assistant compensation Other Course Expenses Advising 15,000 20,000 30,000 30,000 Course Development 22,000 Reception/Graduation, Speaker fees 5,175 9,225 12,600 14,625 Classroom and office rent - - - - Online/tech support 7,500 5,000 5,000 5,000 C Subtotal 49,675 34,225 47,600 49,625 Support Expenses Marketing & Industry/International Recruitment 63,333 65,233 67,190 69,206 Faculty Program Director 85,000 87,550 90,177 92,882

Program Administration 85,000 85,430 87,933 90,511 D Subtotal 233,333 238,213 245,300 252,599 E = B+C+D Total Direct Expenses 427,728 432,158 452,620 461,944 Sharing Assessments Chancellor 228,960 251,640 20.0% Assumes Chancellor waiver in 1st two years VCHS 183,168 201,312 16.0% Assumes VC waiver in 1st two years Division 32,130 54,306 80,136 88,074 7.0% Financial Aid (accounted for above) - - - - Off-the-top on revenue F Subtotal 32,130 54,306 492,264 541,026 G = E+F Grand Total Expenses 459,858 486,464 944,884 1,002,970 H = A-G Surplus/(Deficit) to Program (858) 289,336 199,916 255,230

Total Degree Cost Fees - 2 Year Completion Yr 1 Yr 2 Total Units 34 14 48 Fee $1,000 $1,000 SSP Tuition 34,000 14,000 48,000 Graduate Campus Based Fees 897 909 1,806 Assume start in 20/21. LC 10/7/19 Student Service Fee 1,128 1,128 2,256 Charged quarterly in FWS Total Degree Cost Fee Estimate* 36,025 16,037 52,062

Total Degree Cost Fees - 1 Year Completion Yr 1 Yr 2 Total Units 48 48 Fee $1,000 SSP Tuition 48,000 48,000 Graduate Campus Based Fees 897 897 Assume summer start or summer finish so only FWS CBF's assessed - see CBF tab for scenarios. LC 10/7/19 Student Service Fee 1,128 1,128 Charged quarterly in FWS Total Degree Cost Fee Estimate* 50,025 50,025

* Does not include GSHIP (which can be waived) or other expenses (parking etc). Does not include one-time document fee. Thursday, February 27, 2020 at 4:36:27 PM Paciﬁc Standard Time

Subject: Re: New Masters Program Date: Friday, November 8, 2019 at 3:04:33 PM Paciﬁc Standard Time From: Lucila Ohno-Machado To: Mckerrow, James CC: El-Kareh, Robert, Day, Michele

Thanks, this was fast!

From: "Mckerrow, James" Date: Friday, November 8, 2019 at 2:54 PM To: Lucila Ohno-Machado Cc: "El-Kareh, Robert" Subject: FW: New Masters Program

We have a “yes”

Jim

From: "Khosla, Pradeep" Date: Friday, November 8, 2019 at 2:45 PM To: "Mckerrow, James" Cc: "Ouillet, Pierre" , "Lepe, Sylvia" Subject: Re: New Masters Program

Yes that sounds reasonable. I have copied Sylvia and Pierre so the defn of what is being given up Us clear. Thanks

Pradeep K Khosla Chancellor, UC San Diego

Sent from my iPhone

On Nov 8, 2019, at 1:34 PM, Mckerrow, James wrote:

Dear Pradeep:

Page 1 of 2 Rather than meet with you I thought we could solve this by email. Lucila Ohno-Machado and I are launching a joint Masters program in Health Informacs. It has the enthusiasc endorsement of David Brenner. It been endorsed by SSPPS CEP, SOM CEP, and Health Sciences Faculty Council. It is now at Academic Senate Graduate Council prior to going to UCOP. Grad Counsel is asking if we have your permission to forgo the usual Chancellor’s tax for 3 years so we are not in deﬁcit. In 3 years we expect to be at “steady state” with tuion.

Thanks,

Jim and Lucila

Page 2 of 2

October 4, 2019

James McKerrow, MD, PhD Dean and Distinguished Professor Skaggs School of Pharmacy and Pharmaceutical Sciences UC San Diego 9500 Gilman Drive MC 0657

Dear Dean McKerrow,

I have reviewed your proposal to launch the Master of Science Program in Health Informatics in partnership with the Department of Biomedical Informatics. I am confident this program will provide incredible educational opportunities for the Health Sciences, both for students in the School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences.

I am delighted to offer my full endorsement of this new graduate program. To help ensure the program’s success, the Health Sciences will waive the Vice Chancellor tax for the program’s first three academic years.

Sincerely,

David A. Brenner, MD Vice Chancellor for Health Sciences UC San Diego

cc: S. Garfin G. Hasegawa A. Marshall L. Ohno-Machado P. Ouillet

Office of the Vice Chancellor for Health Sciences 9500 Gilman Drive, MC 0602  La Jolla, CA 92093-0602 T: (858) 534-1501  F: (858) 822-0084  https://medschool.ucsd.edu/vchs Monday, October 7, 2019 at 4:07:22 PM Paciﬁc Daylight Time

Subject: RE: Updated MSHI budget Date: Monday, October 7, 2019 at 3:07:46 PM Paciﬁc Daylight Time From: Cruz, Louie To: Day, Michele CC: Herbst, Nancy, El-Kareh, Robert, Le, Kim Chi Aachments: Budget for MS- Health Informacs v6 Revised CBF.xlsx

Hi Michele,

Sorry for the delay. I quickly looked over the logic and it sll seems ﬁne (just changes to units). The P&L does reﬂect the older revenue sharing arrangement but as I recall with Nancy, it would be disrupve to revise this to the newer SAPD sharing arrangement at this me (during the Grad Div reviews). Once the program is launched we would need to revisit those sharing calculaons but it would not alter the results in terms of self-supporng rampup.

One item I did edit was the total degree cost esmates at the boom of the main tab – I adjusted for an esmated 20/21 start and also created the 1-year proﬁle (assuming a summer start or summer ﬁnish). The cost would be slightly less owing to the campus and student service fee only being assessed over FWS – this is consistent with other MAS programs that happen to start in the summer (SIO & some Rady). If you can incorporate this great, but otherwise if you’ve already submied then at least we have this in case the cost of the 1 year schedule is asked.

Louie

From: Day, Michele Sent: Monday, October 7, 2019 12:41 PM To: Cruz, Louie Cc: Herbst, Nancy ; El-Kareh, Robert ; Le, Kim Chi Subject: Re: Updated MSHI budget

Hi Louie,

Thank you for your past reviews of our budgets for our MS in Health Informacs proposal. The Grad Council asked us to evaluate whether we’re able to reduce the total number of units. We reduced the total number of units from 52 to 48 so that a student could potenally complete the program in 1 calendar year. We modiﬁed the budget dra to reﬂect 48 units, which changed esmates wherever units were used in calculaons. No other changes were made. We sll see a surplus in Years 2, 3 and steady state.

Due to ming constraints we are subming the aached version to Grad Council today, but welcome any feedback and approvals you’re able to provide.

Thanks, Michele

Page 1 of 3 From: Cruz, Louie Sent: Monday, April 01, 2019 8:58 AM To: Herbst, Nancy Cc: Le, Kim Chi Subject: RE: Updated MSHI budget

Hi Nancy,

I reviewed the latest dra and conﬁrm that it reaches net surplus in all years given the assumpons modeled.

I did insert a few rows in the revenue buildup secon to reﬂect a “Cohort 4”, simply so that it did not look like Cohort 2 was bleeding into into 3 years in the Steady State column. No changes to revenue or the boom line. It looks like the enrollment ramp and fee is a bit more conservave along with the increased Director costs (per below).

I also noted the assumed waiver on the Chancellor and VC assessments in years 1 -2. I put a statement to this eﬀect oﬀ to the right. I would simply note (separate from the academic review) that we would need something in wring or email on this, for the Chancellor waiver when it ulmately comes me to assess aer year 1.

Thank you – I aached a version with the minor tweak to the revenue secon.

Regards, Louie

Louie Cruz Principal Budget Analyst University of California, San Diego Campus Budget Office Mail Code 0936 Office 858-822-1901 [email protected]

From: Herbst, Nancy Sent: Thursday, March 28, 2019 2:21 PM To: Cruz, Louie Subject: Updated MSHI budget

Hello Louie,

Page 2 of 3 Hello Louie,

We incorporated a few of your suggested and made a few modiﬁcaons. The main items are:

1) Ramped up enrollment 15, 20, then 30/year 2) Changed the fee/unit to $1,000 3) Added a new “steady state” tab since year 3 is not steady state anymore 4) Added a “Steady State” column to the 3-year overview 5) Increased the program director to 0.2 FTE for co-directors & increased program admin to reﬂect 1.0 FTE + beneﬁts.

Please let us know if this would change your ﬁnal assessment of the program.

Warmly,

Nancy

Page 3 of 3 Appendix(VII:(Feedback(from(Campus(Review(Committees(and(Other(Entities(

! ( (

Date: September 30, 2016

To: Lucila Ohno-Machado, M.D., Ph.D. Chair, Department of Biomedical Informatics Co-director, MS Program in Health Informatics

Robert El-Kareh, M.D., MS, MPH Assistant Professor of Medicine Associate Director, MS Program in Health Informatics

Charles Daniels, Ph.D. Associate Dean for Professional Practice, SSPPS Co-director, MS Program in Health Informatics

Nuno Bandeira, Ph.D. Associate Professor, SSPPS Associate Director, MS Program in Health Informatics

From: Gordon Yung, M.D. Professor of Medicine Vice Chair, Committee on Educational Policy

Subject: Proposal for a Master of Science Program in Health Informatics

At its meeting on September 29, 2016, the School of Medicine Committee on Educational Policy (CEP) reviewed the proposal for a Master of Science (MS) Program in Health Informatics. Dr. Robert El-Kareh presented the proposal. Program faculty were available to discuss various aspects of the proposed program.

The CEP strongly supports the establishment of this MS program and believes that it will be a valuable addition to UC San Diego. The CEP voted unanimously to endorse the proposal. The Graduate Programs Education Committee reviewed and endorsed this proposal before it was presented to the CEP.

We wish you success as the proposal moves forward to the next steps in the approval process. The CEP looks forward to the establishment of this program.

Cc: James McKerrow, Ph.D., M.D., Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences William Wachsman, M.D., Ph.D., Chair, Health Sciences Faculty Council Catheryn Yashar, M.D., Chair, Committee on Educational Policy

DATE: July 27 2016

TO: Hailey Marshall Division Coordinator

FROM: T. Mike Hsieh, M.D. Chair, Graduate Program Education Committee (GPEC)

SUBJECT: Proposal for a Master’s Program in Health Informatics

This letter is to endorse your proposal for the Master’s Program in Health Informatics. On July 28, 2016, the GPEC committee reviewed the proposal for this program. Since it is a collaboration between the School of Medicine Department of Biomedical Informatics and the Skaggs School of Pharmacy and Pharmaceutical Sciences, representatives from both programs were present and answered questions from the committee.

Based on the market research presented, it was demonstrated that there is a lack of formalized health informatics programs available in this region. The University of San Diego, School of Nursing offers a Health Informatics program whose target audience is nursing staff and nurse practitioners but is not as in depth of the proposed program. The proposed MS program offered 2 tracks (thesis vs project/exam requirements) to enable both students and working professional to participate. It is financially viable as early as year 2 based on the provided budget plan.

Minor suggestions and concerns were raised by the committee members. Even though a Health Informatics PhD program co-exists with other PhD programs at UCSD, the administrative aspect is managed by other departments. The proposed program will be first administrative effort by the Department of Biomedical Informatics with help from the school of Pharmacy. There also was not an ethics course included in the curriculum which we felt is important in the growing field of health informatics. Representatives agreed with our suggestion and plan on incorporating the topic as a requirement.

At the end, GPEC committee voted unanimously in support for the proposed MS program. We recommend the program to be reviewed by the campus CEP committee.

UNIVERSITY OF CALIFORNIA, LOS ANGELES UCLA

BERKELEY  DAVIS  IRVINE  LOS ANGELES  MERCED  RIVERSIDE  SAN DIEGO  SAN FRANCISCO SANTA BARBARA  SANTA CRUZ

ALEX BUI MEDICAL IMAGING INFORMATICS GROUP DIRECTOR, MEDICAL IMAGING INFORMATICS GROUP DEPARTMENT OF RADIOLOGICAL SCIENCES PROFESSOR, DEPARTMENTS OF RADIOLOGICAL SCIENCES, BIOENGINEERING & BIOINFORMATICS DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA PHONE (310) 794-3540 | FAX (310) 794-3546 924 WESTWOOD BLVD. SUITE 420 E-MAIL: [email protected] LOS ANGELES, CA 90024

Wednesday, December 28, 2016

Nancy L. Herbst Director, Division of Biomedical Informatics Department of Medicine UC San Diego School of Medicine

Re: Review of proposed new Master of Science of Health Informatics at UCSD Dear Nancy: Thank-you for the opportunity to provide review and feedback for UC San Diego’s proposed Master of Science program in Health Informatics. It is exciting to see the formation of such a curriculum, and it fills an important need in both industry and healthcare. My administrative comments are based on a review of the document you sent, and are based on my past experience as a Graduate Council chair at UCLA, as well as serving as a member of the UC-wide Coordinating Council for Graduate Affairs (CCGA), which would likely be the final body to approve this proposal (given that it is a new degree title at UCSD). Comments on the curricular content are from my own experience as a Director of a training program in biomedical informatics. For simplicity, I have divided these comments accordingly below. Administrative questions and suggestions. These are questions that I know we would ask from a Graduate Council perspective in vetting the degree proposal before it goes to CCGA for its review. There may be differences in how UCSD approaches this versus how we handle things at UCLA, but I would assume some commonality: 1. Professional vs. research-oriented (terminal) degree. First, is this meant to be a terminal MS degree? If so, you should make that explicit. A concern may be raised in how the degree program is justified versus its structure. Specifically, a Master of Science program is proposed, with corresponding thesis and comprehensive exam plans, which makes sense. However, the “program need” and opportunities for placement (Projected Need, pages 6-7) seems to suggest more industry-oriented perspectives – which suggests perhaps a professional degree. The stated preference for individuals already with a healthcare background is also pushing this more to a “professional” perspective. One possibility is to make the connection to “research” stronger and to also link this as a segue to associated PhD programs (a mention of this is made on page 4, Relationship to Master and Doctoral programs, but it could be stronger; also, see my comments below). 2. Relation to other UC programs. Somewhat related to the above point, but you should check on this: the UC Davis program, I believe, is a professional degree program, which is a huge difference from a research-oriented program as you’ve designed yours. 3. Program length. The introduction states 1- or 2-year program. I would suggest making it 2 if it’s a thesis. Or, if you want to break it down to something shorter, give the number of quarters. Some specificity is useful here for people reviewing the proposal. 4. Student enrollment. The document states the intent will be a 30-student program. Usually a new program grows slowly and shows the first vs. second year of growth, and then its steady-state enrollment. If you can provide a clear plan for growth and anticipated timetables for rollout of new courses, this would also be helpful. Also, given a target of 30 students total, that would entail 15 students/year (more if the program takes less than two years): there are 22 faculty listed, which means that each faculty would likely be on multiple thesis committees – in addition to their current responsibilities. Are there sufficient faculty to support this number? (It seems like it could be seen as a stretch). 5. Program review. Given that this a new program, your Graduate Council may want to do a review sooner, rather than wait for the typical 8-year review (Section F, Page 3). You may want to suggest that an internal 3-year review may be done and presented to UCSD Graduate Council to ensure that things are “on track.” 6. Program admission. There seems to be an inconsistency between the admission requirements bullets listed (page 3) and the scoring sheet in that non-health degrees are not accepted. Moreover, why is there this particular focus? It seems limited, and would you not also want people from BA/BS programs that are not health- oriented to gain some experience in this area? 7. Program admission. Are there GRE or baseline GPA requirements? (e.g., will the program admit students below a 3.0 GPA?). Also, your TOEFL score in Appendix I is not the same as the text (82 vs. 80?). 8. Program of study. You indicate that teaching opportunities will be made available (Section C, page 3) – what are these, specifically? What courses and what is the intent of having these students teach if they are not going into more academically-oriented positions? This seems like a bit odd for an MS degree. 9. Relationship to Master and Doctoral programs. You indicate that students may continue to a PhD in a department offering specialization in Health Informatics. What PhD programs would these be (list them), and do those programs agree with your assessment? (Statements of support from those other programs’ leadership should be given, if so). 10. Faculty. You have listed the DBMI and SSPPS faculty. Often, when a program is created, we need to know which of these faculty are on state-funded FTEs vs. other funding sources. I’m not sure what classifications or categories UCSD uses for this, but a loose way of putting it is how many of these individuals are on soft money vs. state-funded support? Moreover, what is the allocation between full, associate, and assistant-level faculty that you have listed? This point also goes to the FTE faculty resource requirements (page 10) that are given: unless there are sufficiently state-funded positions behind the program, then it will not be green-lighted. I also do not find the statement that you, “plan to recruit ore based on course needs” a good argument: does this mean you anticipate needing more? Most program reviews would state that already have all the resources needed to support the proposed program. 11. Computing costs. How are your labs funded? How will computers be updated and who provides support for these resources? 12. Space requirements. Where will students be placed (i.e., will they have desks?) and where will the classes be taught? 13. Graduate student support. You indicate that students will likely be self-funded, with some modicum of fellowship support. Please give a detailed fiscal breakdown (e.g., what are the resources from your Graduate Divi- sion Dean?). What is the source of the academic scholarships, and how will they be awarded? More detail is needed in this section. 14. Appendix I Score sheet. The categories listed for research/informatics experience seem odd: why are you looking at individuals who have served as PIs? Curricular questions and suggestions. Overall, the curriculum looks reasonable, though I have two (interrelated) concerns about the database class, and the overall lack of an information-systems oriented course: 1. MS Capstone project. Rather than a thesis/comprehensive exam perspective, one possibility you may want to consider is instead a capstone project. This project could entail some “course” work by the faculty but reduce the need to serve on multiple thesis/project committees, and would also make the program more appealing to prospective employers. 2. Scripting and Databases course (page 13, 17). From the description, this seems like an introductory database (DB) class, with a clinical spin. However, it is not clear to me what the “clinical” spin is – or even if it adds anything necessarily to the learning experience of the student. If the intent is for students to have some background in databases and querying (e.g., using SQL), then a “clinical-specific” environment is not needed (and one may argue that a “general” understanding is better so they can learn how to apply it to the healthcare IT environment). 3. Absence of information systems courses. Having experience with a database (design, querying, etc.) is important. However, a clear problem that may have is understanding how these systems connect, particularly in today’s healthcare IT environment. The electronic health record (EHR) is not a singular entity, but often something that consists of multiple parts that act in an integrated framework. Understanding this framework (and its different designs) and newer approaches is essential for the type of individual you want to train (and the job opportunities you have cited). One possibility is to revise the scripting/DB class to be something along this line, and to have a different (undergraduate?) DB class. If I can be of any further assistance or have questions, please feel free to contact me. Sincerely,

Alex Bui, PhD Director, Medical Imaging Informatics (MII) Group and Training Program Professor, Departments of Radiological Sciences, Bioengineering & Bioinformatics David Geffen School of Medicine at UCLA From: Michael Hogarth To: Herbst, Nancy Subject: Re: Request for your review of a proposed new masters program by UCSD Date: Thursday, December 08, 2016 6:06:32 PM

Hi Nancy:

Thank you for your inquiry and sharing your proposal.

Here are some thoughts to consider.

1. To confirm, you are focusing the program in the application of biomedical informatics to clinical systems. The AMIA definition of this area is “clinical informatics” (subset under ‘health informatics’, which encompasses public health informatics plus clinical informatics). Or, are you including public health informatics? The second sentence in the Aims/Objectives mentions ‘health and welfare of the public’, which could include public health informatics. There are skills/knowledge/abilities that are specific to public health informatics that are typically not covered in most clinical informatics or even health informatics programs. There is significant cross over of general principles/theory but there are elements specific to public health informatics that go beyond the EHR-certification requirements of public health reporting. Examples of these added elements include GIS, vital records systems, biosurveillance systems, immunization information systems, cancer (and other disease) large- scale registries, syndromic surveillance, etc...

2. Awesome to see you reference Ledley and Lusted’s paper! Even in our discipline, many are unaware of that paper.

3. There are some interesting current statistics on our program that you are welcome to include in part D. We have now granted over 100 degrees in our 18 year history. A number are in leadership positions both in public service and private industry. For example, Dr. Lynch is the Chief Medical Officer of Accenture, which successfully competed for the DoD’s multi-billion implementation of an EHR (https://www.linkedin.com/in/cecil-lynch-48a924b). Another is currently the CIO at UCSD Health System (https://www.linkedin.com/in/chrislonghurst).Yet, another is the acting CIO of California’s Health and Human Services and also CIO of OSPHD (https://www.linkedin.com/in/scott-christman-65a2896). Another is the CIO of the California Department of Managed Care (https://www.linkedin.com/in/nareshbaliga). Twenty five of our graduates have been hired across UC Health itself, demonstrating the increasing need for individuals with this training. It is clear that a Master’s offering in this discipline is essential for California’s future.

4. Program of Study thesis/project/exam — This is perfect. Indeed, you want to provide a range of options. What is the knowledge/educational rationale for combining pharmacy informatics with health informatics in the program? Is it driven by pragmatic decisions in terms of program support, or is there a rationale based on a decision to carve out a unique space in the discipline? Comes across as a bit odd. Will attract pharmacists/PharmD’s to informatics, which is great, but I have not seen this kind of combination before.

5. Required units. We require 43 quarter units, which is substantial. 52 seems quite high and could lead to being less competitive in garnering good students given it increases the length and cost of the program significantly.

6. Core Courses — some questions/feedback (1) Are you covering knowledge representation (terminological systems, ontologies, etc..)? (2) Are you covering Information Retrieval (IR) / Knowledge delivery (3) I assume the CDSS at the point of care will include “Clinical Decision Making” (Bayesian decision making, belief networks, etc..) (3) Would make sure you cover evaluation methods in health informatics. Performing evaluations of systems or interventions in health informatics have some unique features (ie, true randomization and blinding can be impossible). (4) Are you planning to cover patient-centered informatics — patient engagement, patient- directed systems, mHealth, sensors and data acquisition using sensors? Looks like the “Current Trends” course would be a place for this kind of content. (5) It was not clear where you cover interoperability, which is emerging as a key component of integrated healthcare information ecosystems required to support the evolution towards value-based, quality-driven healthcare delivery. Interoperability would include methods and principles of interoperability, information modeling to support interoperability, data exchange standards, content standards (terminologies) to support robust interoperability, etc.. P (6) Are you planning to cover “Clinical Genomics Informatics”, which is quickly becoming a factor in clinical informatics — actionable variants and how to manage that information in an EHR. Part of this would be genomic data processing pipelines and tools used by clinical genomics services in arriving at recommended therapeutic approaches for specific diseases where there are FDA-approved treatments targeting these variants. Is that a part of the pharmacogenomics course? (7) Glad to see a practical course on Databases and scripting. I have included introductory classes in both Python and JavaScript as basic programming skills that allow/enable students to do projects. If they don’t have any technical ability, they will have a hard time with thesis/projects. (8) On databases — I currently teach a course on “Data Modeling and Knowledge Representation” where I combine data modeling, databases (both relational and non- relational/noSQL) and terminology/ontologies. It seems to work pretty well for the students. I am happy to share the syllabus and slide decks. I have made the point to our students that the world of ‘data persistence’ has moved far beyond just relational databases, and that a well rounded informaticist needs to understand many database ‘models’, including relational, big table (HBase), and graph databases (ie, like Neo4J). I focus on relational and they perform data modeling from abstract object model to physical tables in a relational model, but I make sure they also learn about NoSQL systems, particularly big table (used in Google Genome Cloud) and graph databases (ideal for ontologies). The main thing I try to get them to understand is the differences in models and schema vs. schemaless and the advantages/disadvantages of both. I also cover “multi-dimensional” data repository design using relational systems, plus they get some insight into “column oriented” databases like Vertica. (9) I LOVE the inclusion of an Ethics course! (10) Will you include clinical natural language processing and text mining in the curriculum? These are emerging as key skills for clinical informaticists. (11) Will you be including machine learning algorithms in the curriculum (12) Will you be including “research informatics” in the curriculum — understanding clinical research (trial phases, randomization, etc..), clinical trial management systems, biorepository management systems (and standards), clinical research study designs and the implications for informatics systems, clinical trial matching (involves entity matching, probabilistic matching, etc..). (13) Will you be including public health informatics content/knowledge in the curriculum.

Overall, very much like the program. Here are some summary thoughts.

(1) 52 units is quite a bit and you might have a hard time recruiting students when you are that high (2) Interoperability is not mentioned in the proposal and it is not clear where that is taught. You have Jim Killeen as faculty, so you have an excellent faculty to cover that topic. (3) The three options (exam/thesis/project) are good. We did exam at first and stopped because it was difficult to establish the exam and maintain a current exam. We went with thesis. I think a good way to go is thesis/project options. Exam could be difficult — a thesis/project provides a process with ability to examine thought process and the student has an opportunity to improve the quality of the work. An exam is pretty final. What if they pass all the courses but get an “D” on the final exam? Would they be granted a degree? Hard to know why they failed and whether they really have the knowledge of simply had a bad day (or are bad test takers). (4) Did not see inclusion of data mining, text mining, machine learning, etc.. but perhaps is in one of the courses. (5) Did not see inclusion of public health informatics even though the stated objective of the program is improving health of the public.

Warm Regards, Mike H

------Mike Hogarth, MD, FACP, FACMI Professor, Department of Internal Medicine, and Professor, Department of Pathology and Laboratory Medicine Ph: (916) 817-9951 https://www.linkedin.com/in/mahogarth

“Legacy is what you give back to the world, not what you get from it” — Andy Hillstrand (FV Time Bandit) ------Sample email requesting assessments and letters of support

From: Herbst, Nancy Subject: Requesting Assessments and Letters of Support for a new Masters of Science program in Health Informatics

Dear ___:

On behalf of Dr. Charles Daniels, I am respectfully sending the following request.

Skaggs School of Pharmacy and Pharmaceutical Sciences and the Health System Department of Biomedical Informatics has identified a strong need for a Health Informatics Master of Science program. In our program development, we have identified courses [list] from your program(s) that could be included as elective courses. We anticipate enrollments in the master’s program of between 20 to 30 students each fall. We anticipate approximately 4 or less students would take any of the elective courses during any one quarter. This is because the students would be required to take two electives out of a pool of approximately 15 course options.

Before finalizing our program, we would be grateful for your assistance in:

1. Frome [nam ] – An assessment of the impact to your unit’s academic and administrative resources; and 2. From each of you a letter of support for the Health Informatics Master of Science Program. I have attached a copy of the proposal for your review.

Thank you for your consideration and feedback. If you have any questions or would like us to provide additional details, please feel free to let us know.

Sincerely,

Charles E. Daniels, BS Pharm, Ph.D. Health Sciences Clinical Professor Associate Dean for Professional Practice Skaggs School of Pharmacy and Pharmaceutical Sciences

Please let me know if you have questions, comments or concerns. Otherwise, we look forward to receiving your support.

Thank you,

Nancy ------Nancy L. Herbst Director, Division of Biomedical Informatics Department of Medicine UC San Diego School of Medicine Mail Code 0728; Telephone: 858.822.2903 Email: [email protected] Responses to email requesting assessments and letters of support

From: [email protected] [mailto:[email protected]] On Behalf Of Dean Tullsen Sent: Tuesday, August 29, 2017 5:13 PM To: Herbst, Nancy Cc: [email protected]; [email protected]; [email protected]; [email protected] Subject: Re: Requesting Assessments and Letters of Support for a new Masters of Science program in Health Informatics

Hi Nancy,

In terms of our enrollments, I think the impact would be manageable. In terms of the new classes you offer (from the proposal) that overlap a little with CSE and the DSE MAS -- I see no problem there.

But we do need to address the concerns raised in the previous notes from my faculty. Underprepared students can have a much bigger impact on the quality of a course than a few too many bodies.

-Dean From: Strong, David Sent: Tuesday, August 29, 2017 10:19 AM To: Herbst, Nancy Subject: Re: Requesting Assessments and Letters of Support for a new Masters of Science program in Health Informatics

Hi Nancy

I apologize for missing this earlier request. This sounds like a terrific program.

In looking through the proposal I see some SDSU courses listed. We are a joint doctoral program and half of our courses take place at SDSU. These would not be good candidates for your students. Advanced Statistical Methods in Public Health PH 627 Behavioral Measurement PH 861 Advanced Theoretical Foundations of Health Promotion & Behavioral Science PH 862

I teach the FPM278 and would welcome qualified students into the course. You likely already received feedback about the FPM 285 Issues & Dilemmas/Clinical Trials course. The new clinical trials course led by Dr Jain would be the new version of this course.

Let me know how I can help.

Best

David

David R Strong,PhD UCSD Program Director SDSU/UCSD Joint Doctoral Program, Public Health Department of Family Medicine and Public Health University of California, San Diego [email protected] From: [email protected] [mailto:[email protected]] On Behalf Of Alin Deutsch Sent: Monday, August 14, 2017 9:39 AM To: Herbst, Nancy Cc: [email protected]; Deutsch, Alin ; [email protected]; [email protected] Subject: RE: Requesting Assessments and Letters of Support for a new Masters of Science program in Health Informatics

Dear Nancy,

The course I teach, cse232b, could absorb 4 more students but the caveat here is that it assumes significant core computer science background before even touching the database-specific material. This includes

-java programming (and overall comfort with object-oriented programming concepts) -software engineering -formal language theory (context-free grammars, automata, inductive definitions), which I suspect are not part of the students background.

Best regards,

--alin From: Arshad Desai [mailto:[email protected]] Sent: Wednesday, August 02, 2017 8:32 AM To: Herbst, Nancy Cc: Kalichman, Michael Subject: Re: Requesting Assessments and Letters of Support for a new Masters of Science program in Health Informatics

Hi Nancy & Charles:

BIOM 219 is the Ethics in Scientific Research course that is offered by the Research Ethics Program under Michael Kalichman’s guidance. If the additional students are acceptable to Michael, the BMS program will be happy to provide a letter of support that includes a statement that there is no impact to our academic or administrative resources.

Best wishes, Arshad September 26, 2019

Dear Dr. El-Kareh,

I typically instruct Human-Computer Interaction (COGS 126) & Information Visualization (COGS 220). In my opinion, these courses can serve as good elective courses for the proposed Master of Science in Health Informatics. I am supportive of including these courses in your proposal.

Sincerely,

James Hollan, PhD Distinguished Professor of Cognitive Science Professor of Computer Science Co-Director UC San Diego Design Lab

El-Kareh, Robert

From: Scott Klemmer Sent: Friday, September 20, 2019 12:14 PM To: El-Kareh, Robert Cc: [email protected] Subject: Re: request to allow students from proposed UCSD health informatics master's program to take your courses as electives sure!

On Fri, Sep 20, 2019 at 10:53 AM El-Kareh, Robert < [email protected] > wrote:

Dear Dr. Klemer,

UCSD's Department of Medicine, along with our School of Pharmacy, is proposing a new Master of Health Informatics program. We anticipate that this will attract an exciting group of students with the skills and interest to put our health- related data to good use in research and applied efforts to improve patient care.

We are hoping to list your courses (Research Topics in Human-Computer Interaction (CSE 216), Interaction Design (COGS 120)) as electives for this program. We expect roughly 1-5 students to enroll in any given quarter. This would likely start at earliest Fall 2020.

Would you be willing to provide a letter (we would provide draft for you to edit) to indicate that you support having your course available as an elective in this program (assuming all pre-requisites completed)?

Thank you very much for your consideration and please let me know if I can provide any further information that would be helpful.

Regards,

Rob

Robert El-Kareh, MD MPH MS 1 Associate Professor of Biomedical Informatics and Medicine

UC San Diego

Email: [email protected]

Phone: 858-822-7776

http://profiles.ucsd.edu/robert.el-kareh

-- Scott Klemmer · Professor · UC San Diego Design Lab · Cognitive Science · Computer Science & Engineering http://d.ucsd.edu/srk · @DesignAtLarge

2 Appendix(VIII:(References( 1( Ledley,(R.(S.(&(Lusted,(L.(B.(Probability,(Logic(and(Medical(Diagnosis.(Science(130,(892?930,( doi:10.1126/science.130.3380.892((1959).( 2( DesRoches,(C.(M.&et&al.(Electronic(health(records(in(ambulatory(care??a(national(survey(of( physicians.(The&New&England&journal&of&medicine(359,(50?60,(doi:10.1056/NEJMsa0802005( 10.1056/NEJMsa0802005.(Epub(2008(Jun(18.((2008).( 3( Jha,(A.(K.,(DesRoches,(C.(M.,(Kralovec,(P.(D.(&(Joshi,(M.(S.(A(progress(report(on(electronic(health( records(in(US(hospitals.(Health&affairs(29,(1951?1957((2010).( 4( Kulikowski,(C.(A.&et&al.(AMIA(Board(white(paper:(definition(of(biomedical(informatics(and( specification(of(core(competencies(for(graduate(education(in(the(discipline.(Journal&of&the& American&Medical&Informatics&Association&:&JAMIA(19,(931?938,(doi:10.1136/amiajnl?2012? 001053( 10.1136/amiajnl?2012?001053.(Epub(2012(Jun(8.((2012).( 5( Campbell,(E.(M.,(Sittig,(D.(F.,(Ash,(J.(S.,(Guappone,(K.(P.(&(Dykstra,(R.(H.(Types(of(unintended( consequences(related(to(computerized(provider(order(entry.(Journal&of&the&American&Medical& Informatics&Association&:&JAMIA(13,(547?556,(doi:10.1197/jamia.M2042((2006).( 6( Msm,(F.(M.(B.,(Frye,(P.(A.(&(Jones,(W.(A.(Health(information(technology:(integration(of(clinical( workflow(into(meaningful(use(of(electronic(health(records.(Perspectives&in&health&information& management,(1((2010).( 7( Richesson,(R.(L.(&(Krischer,(J.(Data(standards(in(clinical(research:(gaps,(overlaps,(challenges( and(future(directions.(Journal&of&the&American&Medical&Informatics&Association&:&JAMIA(14,( 687?696,(doi:10.1197/jamia.M2470((2007).( 8( Halamka,(J.&et&al.(Exchanging(health(information:(local(distribution,(national(coordination.( Health&affairs(24,(1170?1179,(doi:10.1377/hlthaff.24.5.1170((2005).( 9( ((

! ! !

Appendix(IX:(Letters(of(Support( ( (

Wolfgang H. Dillmann, M.D. Helen M. Ranney Distinguished Professor Chair, Department of Medicine [email protected]

April 1, 2019

Lucila Ohno-Machado, MD, PhD Professor of Medicine and Chief, Division of Biomedical Informatics

Re: Letter of Departmental Support for Proposal for a Self-Sustaining Master of Science in Health Informatics

Dr. Ohno-Machado,

I write to express my strong support for the proposal to create a self-sustaining Master of Science in Health Informatics degree program at UCSD. I understand that, under your leadership, the program will help train the next generation of health informatics professionals, across a variety of clinical disciplines.

The Department of Medicine has a long tradition of training and mentoring the next generation of physicians and scientists, and we provide academic oversight for the division faculty involved in this program. For this new program, I support the reuse of the Department of Medicine informatics-related courses that your team has developed and has been successfully teaching since 2010 for the NIH-NLM training program in biomedical informatics, as well as the development of new courses that may need to be created specifically for this program.

I am confident that health informatics will continue to grow as a significant multi-disciplinary field, that UCSD is uniquely positioned to build capacity in this area, and that the proposed program will fill an important gap in our region. I wish you and your team all the success in this new initiative.

Sincerely,

Wolfgang Dillmann, M.D.

Department of Medicine UC San Diego Health Sciences • 9500 Gilman Drive, #0671 • La Jolla, CA 92093 T: 858-822-3345 • F: 858-822-3344 • med.ucsd.edu UNIVERSITY OF CALIFORNIA, SAN DIEGO U C S D

BERKELY • DAVIS • IRVINE • LOS ANGELES • MERCED • RIVERSIDE • SAN DIEGO • SAN FRANCISCO SANTA BARBARA • SANTA CRUZ

Ravindra L. Mehta, M.B.B.S., M.D., F.A.C.P. UCSD Medical Center Professor Emeritus of Medicine Division of Nephrology Director CREST and MAS in Clinical Research Program 200 West Arbor Drive San Diego, CA 92103-8342 Tel: (619) 543-7310 Fax: (619) 543-7420 e-mail: [email protected] April 1, 2019

Lucilla Ohno-Machado MD Professor and Head Division of Biomedical Informatics Department of Medicine UCSD School of Medicine

Re: Self-Sustaining Master of Science in Health Informatics

Dear Dr. Ohno-Machado,

It is my pleasure to write a letter of support for your proposal to create a self-sustaining Master of Science in Health Informatics degree program within the Department of Medicine. The proposed target students include professionals and graduate students interested in developing an informatics and analytic background focused on studying and improving health care delivery. The focus of your proposed program is distinct from that of our Master of Advanced Studies in Clinical Research program that was started in January 2003 and provides a broad-based curriculum for instruction in the principles of patient- oriented research, epidemiology, biostatistics, and health services research and data management. Your proposed program centers much more on the informatics topics than on clinical trials and study design.

One of the most rewarding aspects of the MAS in Clinical Research program has been the multidisciplinary environment, providing an opportunity for the students to interact with researchers from other disciplines. I believe your MAS program in Health informatics will foster these interactions further and provide new opportunities for our students in both programs to have access to additional electives. I anticipate that the overlap of potential students between our two programs is sufficiently small to avoid any significant competition for enrollment.

I am highly supportive of the efforts as outlined in your proposal and wish you the best with your program.

Sincerely,

Ravindra L. Mehta, M.D. UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD

BERKELEY × DAVIS × IRVINE × LOS ANGELES × MERCED × RIVERSIDE × SAN DIEGO × SAN FRANCISCO SANTA BARBARA × SANTA CRUZ DEPARTMENT OF COMPUTER SCIENCE AND ENGINEERING 9500 GILMAN DRIVE UNIVERSITY OF CALIFORNIA, SAN DIEGO LA JOLLA, CALIFORNIA 92093-0404 THE IRWIN AND JOAN JACOBS SCHOOL OF ENGINEERING FAX: (858) 534-7029

Dear Dr. Ohno-Machado,

4/8/2019

Re: Letter of Support for Self-Sustaining Master of Science in Health Informatics

It is my pleasure to write a letter of support for this proposal to create a self-sustaining Master of Science in Health Informatics degree program within the Department of Medicine. The proposed target students include professionals and graduate students interested in developing an informatics and analytic background focused on studying and improving health care delivery. The focus of this proposed program is distinct from that of our PhD program in Bioinformatics and Systems Biology, including the biomedical informatics track, as your program is intended for students seeking a Master’s degree who expect to apply clinical informatics approaches in practice. Some of the coursework is shared and we expect that some of your students may opt to further their education by applying for the PhD degree program. These students would be qualified and have competitive applications given the education received from the core courses from this program. I am highly supportive of the efforts and wish you the best with your program.

Sincerely,

Vineet Bafna, PhD Professor, CSE, #4218 Director, Bioinformatics and Systems Biology Ph.D. Program UC San Diego 9500 Gilman Drive La Jolla, CA 92093-0404 [email protected] 858-822-4978 (O) 858-534-7029 (F) http://www.cs.ucsd.edu/~vbafna

Appendix(X:(Combined(CVs/Biosketches(for(Program(Faculty(( (

Moscow Inst. Physics & Technology, Moscow M.S. 07/1980 Molecular & Chemical Biophysics Moscow State University, Moscow Ph.D. 05/1984 Protein Structure Prediction

A. Personal Statement I am very excited about being a part of the Health Informatics Master of Science Program at the University of California, San Diego. My lab has built the Pocketome database and we also parse, restructure and mine several 'big-data' databases including expression data, genomics and epigenomics data, clinical data related to various therapeutics (eg the FDA adverse effect reporting system data). We train students and graduate students from several programs and are excited about the proposed master of science program. It is long overdue.

B. Positions and Honors Positions: 1984-1986 Postdoctoral research, Laboratory of X-ray Crystallography, Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow 1986-1989 Group Leader, Laboratory of Plant Genetic Engineering, Engelhardt Institute of Molecular Biology, USSR Academy of Sciences 1991-1994 Staff Scientist, EMBL, Heidelberg 1994.1999 Associate Professor of Biochemistry and Mathematics, New York University (Tenured 1997) Courant Institute of Mathematics, Skirball Institute 1999 -2009 Professor, Department of Molecular Biology, The Scripps Research Institute 1999-2002 Director of Computing and IT. Novarits Functional Genomics Institute. 2007-2009 Adjunct Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego 2009- Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego

Other Experience and Professional Memberships: • SYRRX Inc (now Takeda-LJ), Board of Directors, San Diego, California, 2000-2002 • Plexus Vaccines, Inc., Scientific Advisory Board, San Diego, California, 2000 • Molsoft, LLC., Founder in 1994 • Journal of Molecular Recognition Advisory Board, 1998 - present • German Ministry of Science, Scientific Advisory Board on Bioinformatics, 2001 • Member, Joint Development Committee (JDC) for Novartis Computational Chemistry and Drug Discovery Group, 2006 - present • 2002-2009: chairman of the Structure Based Drug Design session and an organizer of the annual Miptec Drug Discovery conference and exhibition in Basel, Switzerland. • Cancer Genomics and Proteomics Editorial Board, 2006 - present • John Wiley & Sons WIRES-CMS – International Advisory Board member 2008-2015 • Computational Biology and Chemistry: Advances and Applications Honorary Editorial Board, 2008 – now • NIH peer review panels, 2009, 2012, 2013, 2016 (AARR) • Journal of Computer-Aided Molecular Design Editorial Board, 2011 – present • Perspectives in Drug Discovery and Design. Editorial Board, 2012 – present • European Bioinformatics Institute review panel (2015) • Hong Kong Polytechnic University’s State Key Laboratory of Chirosciences, advisory panel – 2011- present • Swiss National Science Foundation, National Centres of Excellence Internat’l. Review Panel – 2011- now

Honors: 2003 – Princess Diana medal, Sydney, Australia 2006 - “The Innolec Lectureship in Cheminformatics”, Masaryk University, Czech Republic 2007 - University of California, San Diego Faculty and Staff Excellence Award, presented by Skaggs School of Pharmacy and Pharmaceutical Sciences Associated Student Body 2016 – Recipient of the American Association of Colleges of Pharmacy Teacher of the Year Award 2018 – Student-voted faculty of the year award, UCSD, SSPPS 2018 – Recognition as top 1% most performing and cited faculty, https://hcr.clarivate.com/

C. Contribution to Science

1. Co-invented Equations for Molecular Dynamics in Internal Coordinates - the first equations of motion for multiple flexible molecules with arbitrary internal bond, angle and torsion constraints. a. Mazur, A.K., Abagyan, R. New methodology for computer-aided modelling of biomolecular structure and dynamics. 1. Non-cyclic structures. J Biomol Struct Dyn, 1989, 6(4): 815-32, , Abagyan, Mazur .. 2. Local deformations and cycles, JMBSD, 2989. (first molecular dynamics equations in internal coordinates)

2. Invented efficient stochastic global optimization algorithm in internal coordinates with collective movements and square root sampling. First successful loop designs and protein docking predictions. a. Borchert, T.V., Abagyan, R., Kishan, K.V., Zeelen, J.P., Wierenga, R.K. The crystal structure of an engineered monomeric triosephosphate isomerase, monoTIM: the correct modelling of an eight-residue loop. Structure, 1993, 1(3): 205-13 (first blind proof of concept). b. Abagyan, R, Totrov, M & Kuznetsov, D ICM - a new method for protein modelling and design. Applications to docking and structure prediction from the distorted native conformation J.Comp.Chem., 1994, 15, 488-506. http://xablab.ucsd.edu/pdf/94_icm.pdf c. Abagyan, R., Totrov, M. Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins. J Mol Biol, 1994, 235(3): 983-1002. (the global optimizer with collective fragment moves). d. Totrov, M., Abagyan, R. Detailed ab initio prediction of lysozyme-antibody complex with 1.6 A accuracy. Nature Struct Biol, 1994, 1(4):, 259-63, 7656055 (a breakthrough in protein docking with flexible interfaces).

3. Led the development of the accurate ligand and peptide docking and virtual ligand screening of large chemical databases. Led the development of ligand-guided modeling and its biological applications including GPCRs and nuclear receptors. a. Totrov, M., Abagyan, R. Flexible protein-ligand docking by global energy optimization in internal coordinates. Proteins, 1997, Suppl 1, 215-20. b. Zhou, Y., Abagyan, R. How and why phosphotyrosine-containing peptides bind to the SH2 and PTB domains. Fold Des., 1998, 3(6): 513-22, (the first predictive peptide docking simulations). c. Cavasotto, C.N., Orry, A.J., Abagyan, R.A. Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors. Proteins, 2003, 51(3): 423-33 (the first demonstration of the feasibility of receptor de-orphanization through metabolite docking). d. Katritch, V. Abagyan, R. GPCR agonist binding revealed by modeling and crystallography. Trends Pharmacol Sci, 2011, 32(11): 637-43 (the story of the accurate prediction of conformational changes associated with agonist binding). PMC3200445

4. Introduced the term and concept of the Pocketome of an organism. Led the compilation and maintenance of the public Pocketome database. Docking-based polypharmacology prediction. a. Kufareva, I., Ilatovskiy, A.V., Abagyan, R. Pocketome: an encyclopedia of small-molecule binding sites in 4D. Nucleic Acids Res, 2012, 40, D535-40, (structural systems biology: comprehensive pocketome for a docking scan). PMC3245087 c. Kufareva, I., Abagyan, R. Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states. J Med Chem, 2008, 51(24): 7921-32 (target profiling by docking). d. Chen YC, Totrov M, Abagyan R Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping. Future Med Chem, 2014, 6, 1741-55, PMC4285145 A list of over 280 Published articles or chapters can be found here: http://ablab.ucsd.edu/ex/pubs/pubs.html

D. Research Support

Ongoing Research Support 2 R01 GM071872-10A1 (Principal Investigator, now NCE) 8/1/09-5/31/19 Flexible Macromolecular Docking The major goal of this project is the development of efficient computational methods for prediction of transient association geometries of flexible peptides and proteins. Role: PI

NSF CHE-1609501 (Principal Investigator) 9/1/16-8/31/19 Bioactive transformation products The project is focused on a high throughput characterization of generating alerts about endocrine disrupting or toxic metabolites in water treatment facilities. Role: co-PI

Completed Research Support 1 R01 GM074832 Abagyan (PI) 5/1/06-4/30/11 Novel Druggable Exosites in Protein Kinases The major goals of this project include systematic screening for locations of protein kinase exosites as well as their small molecule modulators using structure-based methodologies. Role: PI

1U01GM094612-01 (Handel) 7/1/10-6/30/15 Structure, Dynamics and Activation Mechanisms of Chemokine Receptors The goal is structural and biophysical characterization of chemokine receptors and receptor complexes that can aid drug discovery efforts aimed at improving ligand affinity, efficacy and selectivity. Role; Co-Investigator

U54GM094618 (Stevens) 9/1/10-12/31/15 Centers for Membrane Protein Structure Determination The goals are to use protein engineering to help CMPD with design of crystallizable constructs of G-protein coupled receptors and to assist in the integration and dissemination of GPCR data to the broad scientific community. Role: Co-Investigator BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES.

NAME POSITION TITLE Bandeira, Nuno Filipe Cabrita Associate Professor, eRA COMMONS USER NAME (credential, e.g., agency login) Skaggs School of Pharmacy and Pharmaceutical nbandeira Sciences, Dept. Computer Science and Engineering EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) New University of Lisbon, Portugal B.Sc. 07/97 Computer Science New University of Lisbon, Portugal M.Sc. 04/01 Artificial Intelligence University of California, San Diego, USA Ph.D. 07/07 Computer Science University of California, San Diego, USA Postdoc 07/08 Comp. Proteomics

A. Personal Statement

My research focuses on the development of algorithms and statistical models for high-throughput interpretation of tandem mass spectrometry (MS) data of metabolites, peptides (including endogenous linear, non-linear and non-ribosomal peptides) and proteins. In addition to advancing the state of the art in traditional computational mass spectrometry, the scope of my research is further revealed by my leading role in the development of the spectral networks paradigm for the interpretation of MS/MS data – a departure from the traditional one-spectrum-at-a-time approaches to a new paradigm based on single-consensus-for-all-related- spectra. As a consequence, I have proposed novel algorithms for automated de novo sequencing of complete antibodies (with Genentch Inc.) and mixtures of modified proteins (with Broad Institute of MIT and Harvard), discovery of highly-modified peptides and putative novel PTMs in cataractous lens (with Pacific Northwest National Lab) and de novo peptide sequencing with multi-spectra protocols for linear (with Max Planck Institute for Biochemistry) and non-linear cyclic peptides (with Pieter Dorrestein, at UCSD). We have also shown how spectral clustering algorithms can be used to transform over 1 Billion spectra (acquired at Pacific Northwest National Lab over an 8-year period) into a searchable spectral archive that can be used for identification of known compounds and for detection of unknown molecules re-occurring in samples from multiple different species. In addition, we have also recently shown how molecular spectral networks algorithms can be adapted to find related spectra from any class of molecules, including metabolites, peptides, glycans, lipids and natural products. My lab has also developed novel algorithms for identification of multiplexed spectra and for analysis of protein- protein interactions by identification of cross-linked peptides. As the founding Executive Director for the UCDS Center for Computational Mass Spectrometry I have also led the investment of over 15 man-years of software engineering developments to integrate these algorithms into a robust, easy-to-use software platform that any lab can install locally or run online without requiring any prior bioinformatics expertise. To further facilitate widespread access to novel developments, our Center provides internet access to a compute cluster with over 2,900 cores and 2 petabytes of storage space available to store and search data submitted through the Center’s public website. Altogether, this infrastructure has already enabled the analysis of over 10 billion spectra in >700,000 searches from ~30,000 users in 130+ countries and defines the foundation for the CCMS Mass spectrometry Interactive Virtual Environment (MassIVE), designed to store, analyze and visualize all publicly available mass spectrometry data. These were also the foundation for the GNPS platform for crowdsourced annotation of naturals products reference spectra and for automated propagation of consensus identifications to hundreds of public datasets shared by the community. In summary, I have a demonstrated record of successfully developing novel paradigms and distributed algorithmic approaches for high-throughput interpretation of mass spectrometry data and my laboratory has the experience and expertise required to precisely formulate, solve, implement, test and deliver the computational tools required for the success of this project.

65 B. Positions and Honors

Positions and Employment 1997-1998 Software Architect, Holos, Portugal 1998-2002 Lecturer, Department of Informatics, New University of Lisbon, Portugal 2003-2007 Graduate Student Res., Computer Science and Eng., University of California, San Diego 2007-2008 Postdoctoral scholar, Computer Science and Eng., University of California, San Diego 2008-2010 Assistant Project Scientist III, UCSD Center for Algorithmic and Systems Biology 2010-2014 Adjunct Assistant Professor, Computer Science and Eng., University of California, San Diego 2010-2014 Assistant Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD 2008- Executive Director, NIH/NCRR Center for Computational Mass Spectrometry 2012- Executive Committee of the Institute for Metabolomic Medicine, UCSD 2014- Associate Professor, Computer Science and Eng., University of California, San Diego 2014- Associate Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD

Other Experience and Professional Memberships 1999 Instituto Superior de Ciência e Tecnologia, Maputo, Mozambique, Invited lecturer 2000 Instituto Superior de Ciência e Tecnologia, Maputo, Mozambique, Invited lecturer 2001 Instituto Superior de Ciência e Tecnologia, Maputo, Mozambique, Invited lecturer 2002 Universidade Nacional de Timor Lorosa’e, Dili, East Timor, Invited lecturer 2006 RECOMB Satellite Conference on Computational Proteomics, Local organizer 2006 Algorithmic Biology 2006, Conference co-organizer 2006- American Society for Mass Spectrometry, Member 2006- Human Proteome Organization, Member 2006- International Society for Computational Biology, Member 2008 La Jolla Proteomics Conference, Program Committee Chair 2008- UCSD Center for Algorithmic and Systems Biology, Member 2008 Gulbenkian Institute for the Sciences, Invited lecturer 2009 Gulbenkian Institute for the Sciences, Invited lecturer 2010 RECOMB Satellite Conference on Computational Proteomics, Program Committee Chair 2010-12 Proteome Informatics Research Group (iPRG), ABRF, Member 2011 RECOMB Satellite Conference on Computational Proteomics, Program Committee Chair 2012-13 ASMS Digital Communications Committee member 2012 RECOMB Satellite Conference on Computational Proteomics, Program Committee Chair 2013 NIH/NCI workshop on the Future of Data Storage Repositories, co-organizer 2012- Molecular and Cellular Proteomics Editorial Board member 2012- BMC Bioinformatics, Editorial Board member 2012- Journal of Proteome Research, Editorial Board member 2017-19 Journal of Proteome Research, Editorial Advisory Board member 2017-19 US HUPO Board of Directors

Honors 1998 Fulbright fellowship for paper presentation (IEEE’s IJCANN’98) 1993-1997 B.Sc. fellowship, Portuguese CMF 1999 M.Sc. dissertation fellowship, Portuguese Foundation for Science and Technology 2002-2006 Ph.D. fellowship, Portuguese Foundation for Science and Technology (2002-2006) 2006 HUPO Young Investigator Award, HUman Proteome Organization (HUPO’2006) 2007 Ph.D. Dissertation Award, Computer Science and Eng., University of California, San Diego 2010 Genome Technology, named as one of “Tomorrow’s PIs” 2012 Emerging Investigator, Molecular BioSystems, featured on special issue cover 2013 Sloan Research Fellow, Alfred P. Sloan Research Fellowship Award

66 C. Contribution to science

1. De novo sequencing and identification of peptides and proteins; while the canonical versions of most protein sequences are well known for model organisms, there are many scenarios where therapeutic discovery requires methods to determine sequences directly from experimental MS data; examples from ongoing collaborations include: antigen-enriched or mutated mono/poly-clonal antibodies, novel toxins in snake, scorpion and spider venoms. Our developments have improved the length of de novo sequences by ~20x (now nearing full protein length) while simultaneously improving sequencing accuracy 8-10x, thus nearly reaching the sequencing accuracy of DNA sequencing technologies. Furthermore, our recent database search algorithms have improved peptide identification in large search spaces 20x larger than regular proteomes (e.g., six frame translations of Human or other genomes) by reducing identification p-values by 6-10 orders of magnitude. a. N Bandeira, K Clauser and PA Pevzner. Shotgun Protein Sequencing: Assembly of Peptide Tandem Mass spectra from Mixtures of Modified Proteins. Mol Cell Proteomics, 6:1123-34, 2007 b. N Bandeira, V Pham, PA Pevzner, D Arnott and JR Lill. Shotgun Protein Sequencing of Monoclonal Antibodies by Mass Spectrometry. Nature Biotechnology 26:1336-8, 2008. PMC2891972 c. Guthals A, Clauser KR, Frank AM, Bandeira N. Sequencing-grade de novo analysis of MS/MS triplets (CID/HCD/ETD) from overlapping peptides. J Proteome Res. 2013 Jun 7;12(6):2846- 57. PMC4591044 d. Guthals A, Boucher C, Bandeira N. The generating function approach for peptide identification in spectral networks. Proceedings of the 18th annual conference in REsearch in COmputational Molecular Biology (RECOMB 2014), Springer-Verlag, J Comput Biol. 2015 May;22(5):353-66.

2. Polymorphism-tolerant searches and discovery of Post-Translational Modifications (PTMs); database searching using canonical protein sequences is still very limited in that most searches ignore sequence polymorphisms and only allow for 4-8 PTMs (most sample-handling artifacts) out of hundreds of different possible PTMs. We are now capitalizing on our advances in spectral alignment and networks to substantially improve the scope and significance of database search, with preliminary results indicating potential improvements of up to 200% more identifications in highly-polymorphic search spaces. These have enabled advances in privacy protection in clinical proteomics data, cancer proteomics, highly- modified peptides in clinical cataractous lens, neuropeptidomics and proteomics in Alzheimer and Huntington’s disease and metaproteomics of environmental samples. a. N Bandeira, D Tsur, A Frank, and PA Pevzner. Protein Identification by Spectral Networks Analysis. Proceedings of the National Academy of Sciences (PNAS), USA, 104:6140-5, 2007, PMC1851064 b. Na S, Bandeira N, Paek E. Fast multi-blind modification search through tandem mass spectrometry. Mol Cell Proteomics. 2012 Apr;11(4):M111.010199, PMC3322561 c. Wang M, Bandeira N., Spectral library generating function for assessing spectrum-spectrum match significance. J Proteome Res. 12(9):3944-51, 2013. PMC3766387 d. Wang J, Tucholska M, Knight JDR, Lambert JP, Tate S, Larsen B, Gingras AC, Bandeira N. MSPLIT-DIA: sensitive peptide identification for data-independent acquisition. Nature Methods Dec;12(12):1106-8, 2015. PMC4857761

3. Molecular spectral networks; the extension of the spectral networks paradigm to the analysis of tandem mass spectra from any type of molecule has opened new avenues of research for identification, dereplication and detection of unknown compounds in natural products and the first multi-omics 3D map of the human skin. The molecular networks publication in PNAS was recognized in at least two commentaries, including one in Faculty 1000 which included the following statements: “In the kind of advance that happens only a few times per decade, this paper describes how the small molecules in and around a living bacterial colony can be identified and quantified over time and space. [...] The potential of this approach to molecular ecology and the discovery of new bioactive molecules is extraordinary.”. Since then, this approach was key to understanding mechanisms of inter-kingdom metabolic exchange in immunocompromised cystic fibrosis patients and in charting the molecular diversity across dozens of microbial species. These foundations are now supporting our Global Natural Products Social Molecular

67 Networking (GnPS, http://gnps.ucsd.edu) platform designed to transform natural products drug discovery by offering a GenBank-like resource for community-wide sharing and crowdsourced collaborative analysis and annotation of all natural products mass spectrometry data. a. J Ng*, N Bandeira*, W Liu, RG Linington, PC Dorrestein, P Pevzner. Dereplication and De Novo Sequencing of Nonribosomal Peptides. Nature Methods, 6, 596-599, 2009. PMC2754211 *- equal contributions b. J Watrous, P Roach, T Alexandrov, B Heath, JY Yang, RD Kersten, M Van der voort, K Pogliano, H Gross, J Raaijmakers, BS Moore, J Laskin*, N Bandeira*, and PC Dorrestein*, Mass spectral molecular networking of living microbial colonies. Proceedings of the National Academy of Sciences (PNAS), 109(26):E1743-52, 2012 (* corresponding authors) c. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC., MS/MS networking guided analysis of molecule and gene cluster families. Proc of the Natl Acad Sci (PNAS), 110(28):E2611-20, 2013. d. Bouslimani A, Porto C, Rath CM, Wang M, Guo Y, Gonzalez A, Berg-Lyon D, Ackermann G, Moeller Christensen GJ, Nakatsuji T, Zhang L, Borkowski AW, Meehan MJ, Dorrestein K, Gallo RL, Bandeira N, Knight R, Alexandrov T, Dorrestein PC. Molecular cartography of the human skin surface in 3D. Proc of the Natl Acad Sci (PNAS). 2015 Apr 28;112(17):E2120-9. PMC4418856

4. Software platforms and data repositories for Terabyte-scale computational mass spectrometry. The practical utility of any advanced bioinformatics algorithms is directly connected to how well they scale to the analysis of relevant clinical and therapeutic discovery and can only become de facto standards when anyone, anywhere is able to seamlessly apply such algorithms and easily understand their results. In addition, world-wide repositories of raw mass spectrometry data can enable seamless transfer of knowledge between experiments/labs and provide the foundations for a self-reinforcing virtuous cycle towards complete annotation of all spectra ever acquired. I have led 5 developers in the development of the Proteomics Scalable, Accessible and Flexible environment (ProteoSAFe, http://proteomics.ucsd.edu/ProteoSAFe/) web framework for computational mass spectrometry – after over 18 man-years of development, ProteoSAFe has now enabled the analysis of over billions of spectra from ~30,000 users in over 200,000 distinct searches. Based on these developments, we have implemented the petabyte-scale Mass spectrometry Interactive Virtual Environment (MassIVE, http://massive.ucsd.edu) world-wide repository of mass spectrometry data and the GNPS crowdsourced knowledge base repository of metabolomics and natural products MS data (http://gnps.ucsd.edu) at the Center for Computational Mass Spectrometry, where I lead the team of developers as the Center’s Executive Director. As it stands today, MassIVE already stores and redistributes hundreds of terabytes of public mass spectrometry data and is an active member of the ProteomeXchange consortium for the community-wide open interchange of raw data, processed results and mass spectrometry knowledge.

a. Frank AM, Monroe ME, Shah AR, Carver JJ, Bandeira N, Moore RJ, Anderson GA, Smith RD, Pevzner PA. Spectral archives: extending spectral libraries to analyze both identified and unidentified spectra. Nature Methods 8:587-91, 2011 PMC3128193 b. Guthals A, Watrous JD, Dorrestein PC, Bandeira N. The spectral networks paradigm in high throughput mass spectrometry. Molecular Biosystems, Invited cover paper, special issue on Emerging Investigators. 8(10):2535-44, 2012 c. Vizcaíno JA, Deutsch EW, Wang R, Csordas A, Reisinger F, Ríos D, Dianes JA, Sun Z, Farrah T, Bandeira N, Binz PA, Xenarios I, Eisenacher M, Mayer G, Gatto L, Campos A, Chalkley RJ, Kraus HJ, Albar JP, Martinez-Bartolomé S, Apweiler R, Omenn GS, Martens L, Jones AR, Hermjakob H. ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination. Nature Biotechnology 2014 Mar;32(3):223-6. PMC3986813 d. Wang M., Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, [et al, 52 other authors], Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with GNPS. Nature Biotechnology 34(8):828-837, 2016, PMC5321674

D. Research Support

Ongoing Research Support 8 P41 GM 103484-05 (Bandeira, Bafna, Pevzner, PIs) 09/20/08 - 06/30/19 Center for Computational Mass Spectrometry The major goal of this center is to bring modern algorithmic technologies to mass spectrometry and to build a new generation of reliable open access software tools to support both novel developments in mass spectrometry instrumentation and emerging applications of mass-spectrometry. TRD 1: Proteogenomics for the discovery of aberrant cancer genes and antibody repertoires; TRD 2: Antibiotics sequencing and drug discovery; TRD 3: Spectral archives and spectral networks; TRD 4: Universal tools for peptide identification and sequencing; TRD 5: Top-down proteomics; TRD 6: Multiplexed spectra

BR2013-014 (Bandeira) 11/15/2013 – 11/15/2018 Alfred P. Sloan Research Fellowship The goal of this Alfred P. Sloan Research Fellowship is to support the Bandeira lab for developments in Computational & Evolutionary Molecular Biology. Aim: Computational mass spectrometry algorithms

Completed Research Support BR2013-014 (Bandeira) 12/23/2013 – 12/24/2015 Translational Bioinformatics of the NCI60 proteome The goal of this project is to create a searchable spectral archive of identified and unidentified spectra in the NCI60 proteome.

JNJ86347A (Dorrestein, Bandeira) 1/1/2012 – 12/31/2013 Johnson and Johnson Mass spectrometry imaging approaches applied to the identification of pathways to target for the modulation of immune cell function. The major goal of this project is to apply comprehensive mass spectrometry methodologies to the deconvolution of mechanisms of immune activation.

3 P41 GM103484-05S1 (Pevzner) 8/25/2012 – 6/30/2013 NIH/NIGMS Mass Spectrometry Interactive Virtual Environment (MassIVE) The goal of this supplement is to implement and deploy the MassIVE repository for all publicly available mass spectrometry data.

1 R01 GM 097509-01 (Dorrestein, Moore) 4/1/2012 – 2/29/2017 Experiment based genome mining of ribosomal natural products The major goal of this project is to create a set of tools for harnessing the biosynthetic potential of ribosomally encoded natural products through mass spectrometry based genome mining. Aim 1: Mass spectrometry based strategies to detect ribosomally encoded natural products; Aim 2: Proteogenomic based algorithms to discover ribosomally encoded natural products; Aim 3: Determine of the structures and activities of select ribosomally encoded natural products

CURRICULUM VITAE Brian Clay, MD

Department of Information Services Department of Biomedical Informatics Division of Hospital Medicine University of California, San Diego Medical Center

200 West Arbor Drive, Mail Code 8485 San Diego, CA 92103

9560 Towne Centre Drive La Jolla, CA 92121

(619) 471-9194 (office; San Diego) (859) 249-0139 (office; La Jolla) (619) 550-6846 (cell) (619) 290-0450 (pager) (619) 543-8255 (fax) E-mail: [email protected]

Education and Training

Faculty Development:

Mini-Advanced Training Program in Quality Improvement, Intermountain Health Care, Salt Lake City, Utah, 2004. 10 x 10 Course in Bioinformatics, American Medical Informatics Association, 2007. University of California San Diego Physician Leadership Academy, 2007 – 2009. Workshop in Improving Resident Supervision, Association of Program Directors in Internal Medicine National Meeting, Baltimore, Maryland, 2010. Workshop in Conducting Effective Attending Teaching Rounds, Society of Hospital Medicine National Meeting, Washington DC, 2010. Workshop in Milestones-Based Resident Evaluation and Program Structure, Association of Program Directors in Internal Medicine National Meeting, Las Vegas, Nevada, 2011. CHIME/AMDIS CMIO Boot Camp, Ojai, California, 2016.

Residency Training:

Residency in Internal Medicine, Vanderbilt University Medical Center, completed June 2003.

Education:

University of California, San Diego, School of Medicine; M.D., June 2000. University of California, San Diego; B.S. Chemistry/Biochemistry, June, 1995.

Licensure and Certification

California State Medical License A83799 (Issued 7/1/03, last renewed 7/31/17). DEA Number BC7994608 (Issued 10/3/02, last renewed 8/31/17). Certified by the American Board of Internal Medicine, August 2003. Re-certified by the American Board of Internal Medicine, October 2013 (Recognition of Focused Practice in Hospital Medicine) Certified by the American Board of Preventive Medicine in Clinical Informatics, October 2016

Work Experience and Academic Appointments

Health Sciences Clinical Professor of Medicine, Division of Hospital Medicine, Department of Medicine (July 2013 – present) Health Sciences Clinical Associate Professor of Medicine, Division of Hospital Medicine, Department of Medicine (July 2009 – June 2013) Health Sciences Clinical Assistant Professor of Medicine, Division of Hospital Medicine, Department of Medicine. (July 2003 – June 2009)

Associate Program Director, Clinical Informatics Fellowship Program (July 2017 – present) Associate Program Director, Internal Medicine Residency Program (January 2005 – June 2013) Associate Clerkship Director (Hillcrest), Medicine 401 [Core Medicine Third Year Clerkship] (July 2005 – June 2012) Associate Medical Director, Clinical Information Services (July 2006 – June 2012) Medical Director, Hospital Medicine Teaching Services (January 2012 – June 2013)

Chief Medical Information Officer, Inpatient and Hospital Affiliations (July 2016 – present) Interim Chief Medical Information Officer (July 2012 – June 2016)

Committee Positions

School of Medicine and UCSD Medical Center committees:

Graduate Medical Education Committee (Member, 2004 – 2013). Graduate Medical Education Resident Work Environment Subcommittee (Chair, 2010 – 2012). Utilization Review Committee (Member, 2004 – present; Chair, 2005 – 2012). Medical Records Informatics and Oversight Committee (Member, 2005 – present; Chair, 2012 - present). Safe Medication Practices Committee (Member, 2006 – present). Pharmacy and Therapeutics Committee (Member, 2008 – present). Quality Improvement and Utilization Management Committee (Member, 2007 – present).

Ad Hoc Committees for Quality Improvement Projects:

Medication Reconciliation Task Force (Physician Leader, 2005 – 2011; Member, 2012 – present). Glycemic Improvement Committee (Member, 2006 – present). Transitions of Care Committee (Member, 2004 – 2016). Internal Medicine Quality Improvement Committee (Member, 2007 – 2013). Hospital Medicine VTE Management Committee (Member, 2007 – 2016).

Other Positions of Responsibility

Reviewer, Journal of Hospital Medicine (2007 – present). Reviewer, Journal of American Medical Informatics Association (2016 – present).

Clinical Instructor in Electronic Medical Record Use, UCSD Annual New Intern Orientation (2007 – present).

Publications

Articles:

Sittig DF, Salimi M, Aiyagari R, Banas C, Clay B, Gibson KA, Goel A, Hines R, Longhurst CA et al. “Adherence to recommended electronic health record safety practices across eight health care organizations.” J Am Med Inform Assoc 2018 Apr 26. (Epub ahead of print)

Marmor RA, Clay B, Millen M, Savides TJ, Longhurst CA. “The Impact of Physician EHR Usage on Patient Satisfaction.” Appl Clin Inform 2018 Jan; 9(1):11-14.

Shaikh U, Afsar-Manesh N, Amin AN, Clay B, Ranji SR. “Using an online quiz-based reinforcement system to teach healthcare quality and patient safety and care transitions at the University of California.” Int J Qual Health Care 2017 Oct 1; 29(5):735-739.

Jenkins I, Doucet JJ, Clay B, Kopko P, Fipps D, Hemmen E, Paulson D. “Transfusing Wisely: Clinical Decision Support Improves Blood Transfusion Practices.” Jt Comm J Qual Patient Saf 2017 43(8); 389-95.

Sitapati A, Kim H, Berkovich B, Marmor R, Singh S, El-Kareh R, Clay B, Ohno-Machado L. “Integrated precision medicine: the role of electronic health records in delivering personalized treatment.” Wiley Interdiscip Rev Syst Biol Med 2017 9(3) Epub.

Dombrowski W, Clay B, O’Brien JD. “Electronic Health Records Quantify Previously Existing Phenomenon – Physicians Spend Hours Coordinating Care.” JAMA Intern Med 2016 176(8); 1234-5.

Spokoyny I, Cederquist L, Clay B, Meyer BC. “COAST (Coordinating Options for Acute Stroke Therapy): An Advance Directive for Stroke.” Journal of Clinical Ethics 2015 Winter; 26(4): 368.

Maynard G, Kulasa K, Ramos P, Childers D, Clay B, Sebasky M, et al. “Impact of a hypoglycemia reduction bundle and a systems approach to inpatient glycemic management.” Endocrinology Practice 2015 Apr; 21(4): 355-67.

Hofflich HL, Oh DK, Choe CH, Clay B, Tibble C, Kulasa KM, et al. “Using a triggered endocrinology service consultation to improve the evaluation, management, and follow-up of osteoporosis in hip fracture patients.” Joint Commission Journal of Quality and Patient Safety 2014 May; 40(5): 228-34.

Clay BJ, Halasyamani L, Stucky ER, Greenwald JL, and Williams MV. “Brief Communication: Results of a Medication Reconciliation Survey from the 2006 Society of Hospital Medicine National Meeting.” Journal of Hospital Medicine 2008, 3(6): 465-472.

Lee J, Clay BJ, Maynard G, and Zelazny Z. “Indication Based Ordering: A New Paradigm for Glycemic Control in Hospitalized Patients.” Journal of Diabetes Science and Technology May 2008, 2(3): 349-356.

Abstracts:

Popa R, Clay B, Seymann G. “Making Every Drop Count: Drivers of Laboratory Overutilization.” Presented: 2016 Society of Hospital Medicine Annual Meeting, San Diego, California, March 7, 2016.

Kline A, Clay B, Popa R. “Hepatitis C Antibody Testing: Saving Costs by Preventing Multiple Unnecessary Tests.” Presented: 2016 Society of Hospital Medicine Annual Meeting, San Diego, California, March 7, 2016.

Chang W, Hochstein G, Liang N, Clay B, Maynard G, Ford R. “Clinical Outcomes of a Multidisciplinary COPD Inpatient and Transition Pathway.” Presented: 2015 Society of Hospital Medicine Annual Meeting, National Harbor, Maryland, March 30, 2015.

Chang W, Maynard G, Clay B, Liang N, Morris T. “Impact of a Computerized COPD Inpatient and Transition Pathway on Clinical Outcomes.” Presented: 2014 Society of Hospital Medicine Annual Meeting, Las Vegas, Nevada, March 25, 2014.

Lovetro B, Popa A, Lane J, Ha D, Clay B, Martin L, et al. “Clinical Predictors Associated with Proton Pump Inhibitor Guideline Adherence.” Presented: 2014 Society of Hospital Medicine Annual Meeting, Las Vegas, Nevada, March 25, 2014.

Popa R, Clay B, Burtson P, Garza A, Seymann G. “Indication-based Ordering of ECG Monitoring Reduces Inappropriate Utilization.” Presented: 2014 Society of Hospital Medicine Annual Meeting, Las Vegas, Nevada, March 25, 2014.

Chang W, Maynard G, Clay B. “Implementation of a Computerized COPD Inpatient Pathway and Transition Pathway.” Presented: 2013 Society of Hospital Medicine Annual Meeting, National Harbor, Maryland, May 17, 2013.

Koppenbrink K, Clay BJ, Helmons P, Jenkins IH, Martin-Armstrong L, Popa A. “The Impact of an Electronic Order Set in Reducing Overuse of Proton Pump Inhibitors in the Inpatient Population.” Presented: 2012 Society of Hospital Medicine Annual Meeting, San Diego, California, April 2, 2012. Published: Journal of Hospital Medicine 2012, 7(Suppl 2): S42.

Sebasky M, Clay BJ. “A Duo of Unusual Diagnoses in a 45 Year Old Female with Right Leg Pain.” Presented: 2012 Society of Hospital Medicine Annual Meeting, San Diego, California, April 3, 2012; Finalist Designation in Vignettes Category. Published: Journal of Hospital Medicine 2012, 7(Suppl 2): S226-7.

Clay BJ, Goldman S. “Development and Use of a Mass Customized Discharge Instruction Template to Standardize and Improve Discharge Instruction Content.” Presented: 2012 Society of Hospital Medicine Annual Meeting, San Diego, California, April 2, 2012; Finalist Designation in Innovations Category. Published: Journal of Hospital Medicine 2012, 7(Suppl 2): S95-6.

Firestone R, Toledo J, Clay BJ, Chang W. “Evaluation of Acute Exacerbations of Chronic Obstructive Disease at an Academic Medical Center.” Presented: American Society of Health System Pharmacists Midyear Conference, New Orleans, December 3, 2011.

Chadha A, Torriani T, Clay BJ, Seymann G. “A Dirty Business: Implementation of Contact Precautions at a University Teaching Hospital.” Presented: 2011 Society of Hospital Medicine Annual Meeting, Dallas, Texas, May 12, 2011. Published: Journal of Hospital Medicine 2011, 6(Suppl 2): S17.

Clay BJ, Huang B. “Structured Screen Prompts in a Computerized Discharge Instruction Module and Adherence to Discharge Medication Reconciliation Standards.” Presented: 2010 Society of Hospital Medicine Annual Meeting, Washington DC, April 9, 2010. Published: Journal of Hospital Medicine 2010, 5(3)(Suppl 2): S92.

Wu J, Jahansouz F, Wu S, Simonian R, Clay BJ. “Accuracy of Medication Reconciliation at an Academic University Hospital.” Presented: 2009 American Society of Health-System Pharmacists Winter Meeting, Las Vegas, Nevada, December 8, 2009.

Clay BJ, Lee J, Maynard G, and Zelazny Z. “Indication Based Ordering: A New Paradigm for Glycemic Control in Hospitalized Patients.” Presented: 2008 Society of Hospital Medicine Annual Meeting, San Diego, California, April 3, 2008. Published: Journal of Hospital Medicine 2008, 3(Suppl 1): 55.

Clay BJ and Martin-Armstrong L. “Contributing Factors to Short-Term Readmissions to an Academic Center Hospital Medicine Program.” Presented: 2008 Society of Hospital Medicine Annual Meeting, San Diego, California, April 3, 2008. Published: Journal of Hospital Medicine 2008, 3(Suppl 1): 54-55.

Clay BJ. "Reduction in Utilization of Intravenous Proton Pump Inhibitors Following Implementation of a Computerized Physician Order Entry Set." Presented: 2007 Society of Hospital Medicine Annual Meeting, Dallas, Texas, May 23, 2007. Published: Journal of Hospital Medicine 2007, 2(Suppl 2): 45.

Clay BJ and Martin L. "Review of 7-Day Readmissions to a Hospital Medicine Program in an Academic Medical Center." Presented: 2007 Society of Hospital Medicine Annual Meeting, Dallas, Texas, May 23, 2007. Published: Journal of Hospital Medicine 2007, 2(Suppl 2): 46.

Presentations

Clay BJ, Rudkin S. “Making Magic: Two Academic Medical Organizations Sharing One Electronic Medical Record.” EpicSystems Annual User Group Meeting, Madison, Wisconsin, September 3, 2017.

Clay BJ. “Implementation of Epic Secure Chat.” EpicSystems Annual User Group Meeting, Madison, Wisconsin, September 3, 2017.

Clay BJ. “The Role of the CMIO in Cybersecurity Efforts.” Association of Medical Directors in Information Services (AMDIS) Annual Meeting, Ojai, California, June 21, 2017.

Clay BJ. “Quality Improvement Trends and Leading Change.” Western Healthcare Leadership Academy, San Diego, California, May 6, 2017.

Clay BJ. “The Role of the Chief Medical Information Officer in Modern Health Care Systems.” 2017 HIMSS Annual Meeting, Orlando, Florida, February 21, 2017.

Clay BJ. “Implementation of Bedside iPads for Patient Engagement in a New Hospital.” 2017 HIMSS Annual Meeting, Orlando, Florida, February 21, 2017.

Clay BJ. “Using IT to Optimize Clinical Documentation.” 2016 Society of Hospital Medicine Annual Meeting, San Diego California, March 8, 2016.

Clay BJ. “Persistent Heartburn: The Angst Surrounding Proton Pump Inhibitors.” 2012 Topics and Advances in Internal Medicine Annual Regional Meeting, San Diego, California, March 14, 2012.

Lee J, Clay BJ, Kuo G, Lyddane A. “Are EMRs Safe? The Use of Information Technology at the Bedside: Pitfalls and Possibilities.” Oral Presentation at the 3rd Annual Regional Patient Safety Conference, San Diego, California, February 16, 2012.

Clay BJ. “CPOE: A How-Not-To Primer.” Oral Presentation at the University of California San Diego Regional Patient Safety Meeting, San Diego, California, November 10, 2009.

Clay BJ. “A Practical Approach to the Use of Proton Pump Inhibitors.” Oral Presentation at the 2008 Topics and Advances in Internal Medicine Annual Regional Meeting, San Diego, California, March 8, 2008.

Howell E and Clay BJ. "Medication Reconciliation Dilemma." Oral Presentation at the 2007 Society of Hospital Medicine Annual Meeting, Dallas, Texas, May 24, 2007.

Clay BJ. "Patient Safety Initiative -- Discharge Documentation." Oral Presentation at the Veterans' Affairs National Center for Patient Safety Regional Meeting, San Diego, CA, January 24, 2007.

Clay BJ. "Medication Reconciliation." Oral Presentation at the California Association for Healthcare Quality Regional Meeting, Marina del Rey, California, March 15, 2007.

Clay BJ. "Patient Handoffs -- The Perils and the Promise." Oral Presentation at the University of California 1st Annual Regional Patient Safety Meeting, San Diego, California, December 9, 2005.

Invited Lectures

“Managing Patient Care Using EHR Data.” UC San Diego Health Leadership Academy, San Diego, California, November 11, 2017.

“HIPAA in the Modern EHR Era.” Sharp Grossmont Hospital Grand Rounds, San Diego California, April 28, 2016.

“Hospital Discharge and the Electronic Medical Record.” UCSD Department of Medicine Grand Rounds, San Diego, California, September 1, 2010.

“Indication-Based Ordering in CPOE: Examples from the UCSD Inpatient Experience.” UCSD Division of Biomedical Informatics Seminar Series, San Diego, California, March 5, 2010.

Grants and External Funding

Grant from UC Center for Health Quality and Innovation (CHQI) Program, Integrating Patient Care and Health Professions Education to Improve Care Transitions: The UC Health Quality Improvement Network. Co-Investigator at UC San Diego site (principal investigator is Dr. Ulfat Shaikh at UC Davis). Grant funded for $750,000 for five UC sites for September 2011 to June 2014.

Memberships

Member, American Medical Informatics Association, 2007 – present. Member, College of Healthcare Information Management Executives, 2016 – present. Member, Society of Hospital Medicine, 2003 - present. Member, Association of Program Directors in Internal Medicine, 2006 - 2013. Member, American College of Physicians, 2003 - 2013. Society of Hospital Medicine Medication Reconciliation Task Force, 2006 - 2011. University HealthSystem Consortium Medication Reconciliation Task Force, 2007 - 2009. University HealthSystem Consortium Reducing Readmissions Task Force, 2009 – 2010.

Honors and Awards

Nominee, 2008 Kaiser Excellence in Teaching Award, UCSD School of Medicine. Nominee, 2009 Kaiser Excellence in Teaching Award, UCSD School of Medicine. 2008 Faculty Teaching Award, UCSD Internal Medicine Residency Program 2010 Faculty Teaching Award, UCSD Medicine 401 Core Clerkship CURRICULUM VITAE Charles E. Daniels April 2018

University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences UC San Diego Health 9500 Gilman Drive, MC 0657 La Jolla, California 92093-0657 (619) 543-6194 [email protected]

EDUCATION

University of Arizona B.S. (Pharmacy) 1975

Resident in Hospital Pharmacy National Institutes of Health, 1975-1976 Clinical Center (ASHP Accredited)

University of Minnesota M.S. (Social & Administrative 1978 Pharmacy)

University of Minnesota Ph.D. (Social & Administrative 1981 Pharmacy)

EXPERIENCE

Pharmacist-In-Chief University of California San Diego Since 2004 Health System

Clinical Professor Skaggs School of Pharmacy Since 2004 Associate Dean & Pharmaceutical Sciences University of California San Diego

Chief of Pharmacy Department National Institutes of Health 1995-2004 Clinical Center

College of Pharmacy and University of Minnesota 1980-95 Graduate Faculty

Assistant, Associate, University of Minnesota 1980-95 then Senior Associate Director Hospital and Clinic of Pharmacy

Director of Graduate Studies University of Minnesota 1982-90 in Hospital Pharmacy College of Pharmacy

Daniels CV Page 2

Pharmacist Target Pharmacy 1981-1998

Consultant Pharmacist Hennepin Poison Center 1977-1978

Staff Pharmacist NIH, Clinical Center 1976-1977

PROFESSIONAL AFFILIATIONS

American Society of Health-System Pharmacists American College of Clinical Pharmacy Academy of Managed Care Pharmacy International Society of Pharmacoeconomic and Outcomes Research American Association of Colleges of Pharmacy Kappa Psi Pharmacy Fraternity California & San Diego Societies of Health-System Pharmacists

AWARDS, HONORS & RECOGNITIONS

Elected to Membership, Rho Chi Society, 1974 Elected to Membership, Honor Society of Phi Kappa Phi, 1975 Fellow, American Foundation for Pharmaceutical Education 1977-79 University of Minnesota, Doctoral Dissertation Special Grant, 1979-80 Minnesota Society of Hospital Pharmacists Research Award, 1984 & 1986 University Hospitals Consortium Award, 1988 Fellow, American Society of Hospital Pharmacists, Elected in 1993 National Institutes of Health Clinical Center Director’s Award, 1999 and 2003 Recognition as one of the 50 Most Influential Pharmacists of 1999, American Druggist Magazine Best-Practices in Health-System Pharmacy Management Award for Chemotherapy Errors Prevention Task Force, June 4, 2000. Invited Participant, IV Safety Summit, July, 2008. Invited Participant: Pharmacy Practice Model Initiative Summit, 2010. Invited Participant: Pharmacy Residency Stakeholders Capacity Conference, 2011. Elected to membership as correspondant à titre étranger of the Academie Nationale de Pharmacie (France), 2011. Elected to Membership in UC San Diego Clinical Translational Research Institute, 2012. Visiting Professor, King Abdulaziz Medical City, Riyadh & Jeddah, Saudi Arabia, May 2014 John W. Webb Lecture Award for Pharmacy Leadership Excellence, 2014 ASHP Foundation Award for Excellence in Medication-Use Safety, Finalist 2014 Invited Speaker in ASHP Foundation Visiting Leaders Program, 2017-20

PROFESSIONAL REGISTRATION

Arizona State Board of Pharmacy, #6023 Virginia Board of Pharmacy, #0202 012344 California Board of Pharmacy, #29598

Daniels CV Page 3

Immunizing Pharmacist Certification PUBLICATIONS (peer reviewed submissions)

Stark DC and Daniels CE. Availability and Price of Syrup of Ipecac in Community Pharmacies. Contemporary Pharmacy Practice. 1980; 3:195-196.

Daniels CE and Wertheimer AI. Therapeutic Significance of the Drug Lag in the United States. Medical Care. 1980; 18:754-765.

Somani SM, Daniels CE, and Jermstad RL. Patient Satisfaction with Outpatient Pharmaceutical Services. Am J Hosp Pharm. 1982; 39:1025-1027.

Daniels CE, and Wertheimer AI. Analysis of Hospital Formulary Effects on Cost Control. Topics in Hospital Pharmacy Management. 1982; 2:32-49.

Dostal MM, Daniels CE, Roberts MJ, and Giese RM. Comparison of Pharmacist Activities Under Alternative Staffing Arrangements. Am J Hosp Pharm. 1982; 39:2098-2101.

May BM, Daniels CE, and Herrick JD. Evaluation of the Economies of Purchasing Group Size. Am J Hosp Pharm. 1983; 40:263-266.

Kohout TW, Broekemeier RL, and Daniels CE. Work-Sampling Evaluation of an Upgraded Outpatient Pharmacy Computer System. Am J Hosp Pharm. 1983; 40:606-608.

Hassall TH and Daniels CE. Evaluation of Three Types of Control Chart Methods in Unit Dose Error Monitoring. Am J Hosp Pharm. 1983; 40:970-975.

Dostal MM, Daniels CE, and Benson LS. Membership of Hospital Pharmacists in a State Professional Society. Am J Hosp Pharm. 1984; 41:329-330.

Hamm JL, Daniels CE, and Somani SM. Antibiotic Preparation Time in a Horizontal Laminar- Airflow Hood and in a Biological-Safety Cabinet. Am J Hosp Pharm. 1984; 41:1349-51.

Daniels CE. Managing the Inventory Control System. Am J Hosp Pharm. 1985; 42:346-51.

Kelly MT, and Daniels CE. Pharmacy Personnel Opinions of Selected Decentralized Activities. Topics in Hospital Pharmacy Management. 1985; 5(3):49- 54.

Mann HJ, Canafax DM, Cipolle RJ, Daniels CE, Zaske DE, Warwick WJ. Increased Dosage Requirements of Tobramycin and Gentamicin for Treating Pseudomonas Pneumonia in Patients with Cystic Fibrosis. Pediatric Pulmonology. 1985; 1:238-243.

Ryan DM, Daniels CE, and Somani SM. Personnel Costs and Preparation Time in a Centralized I.V. Admixture Program. Am J Hosp Pharm. 1986; 43: 1222-1225.

Daniels CV Page 4

Lundgren LM and Daniels CE. Patient Acuity Indicators as Predictors of Pharmacy Workload. Am J Hosp Pharm. 1986; 43: 2453-59.

Cooper, CB and Daniels CE. Evaluation of Five Systems to Determine Technician Staffing in a Unit Dose Cart-Filling Area. Am J Hosp Pharm. 1988; 45:1333-37.

Koecheler, JA, Abramowitz, PW, Swim S, Daniels, CE. Indicators for the Selection of Ambulatory Patients Who Warrant Pharmacist Monitoring. Am J Hosp Pharm. 1989; 46:729- 32.

Daniels CE and Somani SM. The Automation of Information in Pharmacy. Topics in Hospital Pharmacy Management. 1989; 9(1): 51-61.

Abramowitz, PW and Daniels, CE. Capturing Existing Resources and Reallocating to Clinical Pharmaceutical Services. Topics in Hospital Pharmacy Management. 1989; 9(1): 63-81.

Bjornson DC, Rector TS, Daniels CE. Impact of a Drug-Use Review Program Intervention on Prescribing after Publication of a Randomized Clinical Trial. Am J Hosp Pharm. 1990; 47:1541-6.

Abramowitz PA, Daniels CE, Somani SM, et al. Evolving to Provide Pharmaceutical Care. Topics in Hospital Pharmacy Management. 1992; 12(3): 28-44.

Abramowitz PA, Woller TW, Daniels CE, et al. Multidisciplinary Approach to Reducing Costs in a Health System. Am J Health-Syst Pharm. 1997; 54: 1196-9.

DeCederfelt HJ, Grimes GA, Green L, DeCederfelt R, and Daniels CE. Handling of Gene- transfer Products. Am J Health-Syst Pharm. 1997; 54: 1604-10.

Keravich DK, Daniels CE. Challenges of Thalidomide Distribution in a Hospital Setting. Am J Health-Syst Pharm, 1999; 56:1721-5.

Goldspiel BR, DeChristoforo R, Daniels CE. A continuous-improvement approach for reducing the number of chemotherapy-related medication errors. Am J Health-Syst Pharm. 2000; 57(Suppl 4):S4-9.

Yuan P, Grimes GJ, Shankman SE, Daniels CE, et al. Compatibility and stability of vincristine sulfate, doxorubicin hydroxide, and etoposide phosphate in 0.9% sodium chloride injection. Am J Health-Syst Pharm. 2001; 58:594-8.

DeChristoforo R, Gamble-Bowen S, Daniels CE. Improving communications using an electronic bulletin board. Am J Health Syst Pharm. 2007 64: 245-251.

Chamberlain CE,, Penzak SR, Alfaro RM, Wesley R, Daniels CE, Hale D, Kirk AD, Mannon R. Pharmacokinetics of low and maintenance dose valganciclovir in kidney transplant recipients. American Journal of Transplantation. 2008; 8: 1297-1302.

Daniels CV Page 5

Atayee RS, Best BM, Daniels CE. Development of an Ambulatory Palliative Care Pharmacy Practice. Journal of Palliative Care Medicine. 2008; 11(8): 1077-1082.

Hirsch J, Oen A, Robertson S, Nguyen N, Daniels CE. Patient request for pharmacist counseling and satisfaction: Automated Prescription Delivery System vs. Regular Pick-Up Counter. Journal of the American Pharmacists Association. 2009; 49:73-77.

Helmons PJ, Wargel LN, Daniels CE. Effect of bar-code-assisted medication administration on medication administration errors and accuracy in multiple patient care areas. Am J Health-Syst Pharm. 2009; 66: 1202-10.

Helmons PJ, Dalton AJ, Daniels CE. Effects of a direct refill program for automated dispensing cabinets on medication-refill errors. Am J Health-Syst Pharm 2012; 69:1659-64.

Tallian KB, Hirsch JD, Kuo GM, Chang CA, Gilmer T, Messinger M, Chan P, Daniels CE, Lee KC. Development of a pharmacist-psychiatrist collaborative medication therapy management clinic. J Am Pharm Assoc. 2012; 52: e252-e258.

Daniels CE, Pettit NN. Survey of institutions with multiple pharmacy residency programs. Am J Health-Syst Pharm. 2013; 70:431-4.

Helmons PJ, Kosterink JW, Daniels CE. Formulary compliance and pharmacy labor costs associated with systematic formulary management strategy. Am J Health-Syst Pharm. 2014; 71:407-15.

Helmons PJ, Coates CR, Daniels CE. Decision Support at the Point of Prescribing to Increase Formulary Adherence. Am J Health-Syst Pharm. 2015; 72:408-13.

Awdishu L, Coates CR, Lyddane A, Tran K, Daniels CE, Lee J, El-Kareh R. The impact of real- time alerting on appropriate prescribing in kidney disease: a cluster randomized controlled trial. J Am Med Inform Assoc. 2015;0:1–8. doi:10.1093/jamia/ocv159

Sorensen TD, Shapiro NL, Benedict N, Edwards KL, Chan A, Covey D, Daniels C., Hagemann T, Hemstreet B, Miller W., Mussleman ME. Recommendations for Aligning PGY2 Pharmacy Residency Training and Pharmacy Specialist Board Certification. Pharmacotherapy. 2016;36 (5):e34-e39) doi: 10.1002/phar.1741.

ABSTRACTS PRESENTED

"Use of Patient-Oriented Drug Data Sheets in Discharge Counseling". Presented at the USPHS- COA Annual Meeting, June 12, 1976, New Orleans, LA.

Daniels CV Page 6

"Therapeutics Committee Restrictiveness and Drug Inventory", with Albert I. Wertheimer. Presented for the Economic, Social and Administrative Sciences Section of the Academy of Pharmaceutical Sciences, April 22, 1980, Washington, D.C.

"Isolating Formulary Effects from Management Effects on Controlling Drug Inventory", with P.A. deBlaquiere and A.I. Wertheimer. Presented for the Economic, Social and Administrative Sciences Section of the Academy of Pharmaceutical Sciences, April 22, 1980, Washington, D.C.

"Comparison of Pharmacy Activities Under Alternative Staffing Arrangements", with M.M. Dostal, M.J. Roberts and R.M. Giese. Presented at the 16th Annual American Society of Hospital Pharmacists Midyear Clinical Meeting, December 8, 1981, New Orleans, LA.

"Influence of Drug Formulary Restrictiveness on Drug Purchase Prices", with A.I. Wertheimer. Presented at the 16th Annual ASHP Midyear Clinical Meeting, December 8, 1981, New Orleans, LA.

"Productivity Monitoring through Work Sampling", with M.J. Roberts, R.M. Giese and M.M. Dostal. Presented at the 16th Annual American Society of Hospital Pharmacists Midyear Clinical Meeting, December 8, 1981, New Orleans, LA.

"Outpatient Pharmacy Patient Satisfaction Survey", with S.M. Somani and R.L. Jermstad. Presented at the 16th Annual ASHP Midyear Clinical Meeting, December 9, 1981, New Orleans, LA.

"Membership and Involvement in State Society Activities", with MM Dostal and LB Benson. Presented at the 39th ASHP Annual Meeting, June 7, 1982, Baltimore, MD.

"Impact of an Upgraded Outpatient Pharmacy Computer System", with T.W. Kohout and R.L. Broekemeier. Presented at the 17th Annual ASHP Midyear Clinical Meeting, December 8, 1982, Los Angeles, CA.

"Pharmacy Services Provided to Independent Freestanding Ambulatory Surgical Centers", with D.S. Swanson. Presented at the 40th ASHP Annual Meeting, June 7, 1983, Detroit, MI.

"Evaluation of Quality Circles in Institutional Pharmacy". Presented at the ASHP Midyear Clinical Meeting, Atlanta, GA, December 5, 1983.

"Evaluation of Readability of Pharmacy Policies and Procedures", with C.M. Jolowsky. Presented at the 18th ASHP Midyear Meeting, December 5, 1983, Atlanta, GA.

"Pharmacy Employee Opinions on Who Should Perform What Tasks", with M.T. Kelly. Presented at the 18th ASHP Midyear Meeting, December 8, 1983, Atlanta, GA.

"Antibiotic Preparation Time in Horizontal versus Vertical-Flow Hoods", with J.L. Hamm and S.M. Somani. Presented at the 41st ASHP Annual Meeting, June 4, 1984, Boston, MA.

Daniels CV Page 7

"Patient Acuity and Demands on Pharmacy Services: Is There a Correlation?" with L.M. Lundgren. Presented at the 41st ASHP Annual Meeting, June 6, 1984, Boston, MA.

"A Model for Determining Annualized Net Costs or Savings of Prime Vendor Purchasing Systems", with M.S. O'Brien. Presented at the 42nd ASHP Annual Meeting, June, 1985, Reno, NV.

"Productivity and Cost Analysis of a Centralized IV Admixture Program", with Dee Ryan. Presented at the 42nd ASHP Annual Meeting, June 1985, Reno, NV.

"Development of a Quality Assurance Program for Computerized Medication-Order Entry," with M. Malinowsky and R.L. Broekemeier. Presented at the 20th ASHP Midyear Meeting, December 11, 1985, New Orleans, LA.

"Establishing a Procedure to Monitor Medication System Turnaround Times," with J. Koecheler. Presented at the ASHP 43rd Annual Meeting, June 2, 1986, Denver, CO.

"Development of a Statistical Model for Predicting Workload and Staffing," with C. Cooper. Presented at the ASHP 43rd Annual Meeting, June 3, 1986, Denver, CO.

"Patient Response to Drug Information Programs in the Ambulatory Clinic Pharmacy" with P. Navaratnam. Presented at the ASHP 44th Annual Meeting, June 1, 1987, Washington, DC.

"Evaluation of an Alternative Emergency Medication Syringe System", with A. Richard. Presented at the ASHP 44th Annual Meeting, June 3, 1987, Washington, DC.

"Comparison of Pharmacies in For-Profit and Nonprofit System Hospitals", with M.T. Kelly. Presented at the ASHP 45th Annual Meeting, June 7, 1987, San Francisco, CA.

"Management Structure for Mature Clinical Pharmacy Services" with P.W. Abramowitz, S. Somani and T. Woller. Presented at the ASHP 47th Annual Meeting, June 5, 1990, Boston, MA.

"Expansion of Clinical Pharmacy Services in a Large Teaching Hospital" with P. Abramowitz, S. Somani and T. Woller. Presented at the ASHP 47th Annual Meeting, June 5, 1990, Boston, MA.

“Evaluation of Alternative Methods to Manage IV Solution Charges” with T.W. Kohout. Presented at the ASHP Midyear Clinical Meeting, December 9, 1993, Atlanta, GA.

“Pre-graduate and Post-graduate Clinical Training at the NIH Clinical Center” with N. Kurosawa, et. al. Presented at the 6th Annual Meeting of the Japanese Society of Hospital Pharmacists, September 22, 1996, Sendai City, Japan.

“Development of a Clinical Pharmacist Credentialing Program” with Kerri Jones and Rebecca Slone. Presented at the ASHP Midyear Clinical Meeting, December 10, 1997, Atlanta, GA.

Daniels CV Page 8

“Use of Exit Survey’s to Identify Performance Improvement Opportunities in Ambulatory Pharmacy Prescription Services” with Earnest Alexander and Rebecca Slone. Presented at the ASHP Midyear Clinical Meeting, December 11, 1997, Atlanta, GA.

“In-Vitro Study of Extended-Release Trimetrexate for Intraocular Lymphoma” with Peng Yuan, Michael R. Robinson, George J. Grimes and Gopal K. Potti at AAPS, November 1998, San Francisco, CA.

“Pilot Data on the Use of the QOLIE-31 in an Epilepsy Research Protocol” with Kristin Moran, et al. Presented at the APhA Annual Meeting, March 7, 1999, San Antonio, TX.

“An Epidemiological Approach to Medication Error Monitoring in a Hospital Environment” with Bona Benjamin. Presented at the FIP Annual Meeting, September 6, 1999, Barcelona, Spain.

“Pharmacist Credentialing at the NIH Clinical Center”, with Robert DeChristoforo and Bona Benjamin. Presented at the ASHP Midyear Clinical Meeting, December 6, 1999, Orlando, FL.

“Basic Principles of Supervision for Non-Supervisors” with Robert DeChristoforo and Karen Pascal. Presented at the ASHP Midyear Clinical Meeting, December 9, 1999, Orlando, FL.

“Sustained release implants of triamcinolone acetonide for use in rat models of experimental uveities and neovascularization”, with P Yuan, BA. King, MA Miller, MR Robinson, and GJ Grimes. Presented at the 220th National Meeting of the American Chemical Society, August 22, 2000, Washington, DC.

“Selection criteria for a kidney transplantation quality of life measure”. Presented at the FIP Annual Meeting September 6, 2001, Singapore.

“Doxycycline Intravitreal Implants for Choroidal Neovascularization “ , with Yuan P, Robinson MR. Grimes GJ, and Potti GK. Presented at the Annual Meeting of the AAPS, October 23, 2001, Denver, CO.

“Development of a Drug Information Core Curriculum at Hokkaido College of Pharmacy Using the NIH Practice Model” with N Kurosawa and K Calis. Presented at the ASHP Midyear Clinical Meeting, December 3, 2001, New Orleans, LA.

“The Pharmacist as a Medication System Specialist” with B Benjamin. Presented at the ASHP Midyear Clinical Meeting, December 5, 2001, New Orleans, LA.

“Student’s Perceptions of a Novel Japanese Drug Information Core Curriculum Based on the NIH Practice Model” with N Kurosawa, E Wada and K Calis. Presented at the FIP Annual Meeting, September 5, 2002, Nice, France.

“Lidocaine, Epinephrine, and Bupivacaine Compatibility Study” with D Sperling, P Yuan, G Grimes, G Potti. Presented at the AAPS Annual Meeting, October 25, 2002, Toronto, Canada.

Daniels CV Page 9

“Cost impact of adjunctive G-CSF and/or Darbopoetin therapy in maintenance of pegylated- interferon alpha and ribavirin doses in HIV/HCV co-infected patients.” with Pau A, Agyemang A, McLaughlin M, Suzman D, Metcalf J, Ternisky C, Koratich C, Masur H, Kottilil S, Polis M. Presented at the 10th Conference on Retroviruses and Opportunisitic Infections, February 12, 2003, Boston, MA (Abstract #843).

“The Epidemiology of Clinical Errors in a Research Hospital: Mining Occurrence Reporting Data for Low-Hanging Fruit.” With Lee L, Sparks M, Daine V, Benjamin B, Bergstrom S, Hastings C and Henderson D. Presented at the Society of Healthcare Epidemiologists of America, April 7, 2003, Arlington, VA.

“ Prednisone Decreases Sensitivity to Sirolimus in Kidney Transplant Recipients”, with Chamberlain CE, Kirk AD, Hale D, Swanson J, Cendales L, Mannon R, and Wakefield, T. Presented at the American Transplant Congress , June 2, 2003, Washington, DC.

“A Subconjunctival Implant for Sustained Deliver of Cytochalasin E in a Model of Choroidal Neovascularization”, with Yuan P, Grimes G, Robinson M, Kim H, D’Amato R, Csaky K, Potti G. Presented at the 2004 Pittsburg Conference, March 8, 2004, Chicago, IL

“Weaker and Weaker Still: Steroid Avoidance Does Not Prevent Bone Loss Following Kidney Transplantation”. With Chamberlain CE, Mannon R, Kirk AD, Hale D, Wakefield T. Presented at the American Transplant Congress , May 17, 2004, Boston, MA.

“Development and Evaluation of a Simple Medication Hazard Rating Scale“, with Benjamin B. Presented at the 7th Annual NPSF Patient Safety Congress May 5, 2005, Orlando, FL.

“Applied Pharmacoeconomics in Academic Medicine: Validation of Concept”, with Schoenhaus R. Presented at the ISPOR 12th Annual International Meeting May 22, 2007, Arlington, VA.

“Development of an Ambulatory Palliative Care Pharmacist Practice”, with Atayee R, and Best B. Presented at the ASHP Midyear Clinical Meeting, December 4, 2007, Las Vegas, NV.

“Implementing observer methodology to determine the impact of bar-code medication administration and infusion pump technologies on medication administration errors”. with Helmons PJ. Presented at ACCP Spring Research and Practice Forum, April 8, 2008, Phoenix, AZ.

“Cost-Effectiveness Recombinant Factor VIIa Use in Orthoptic Liver Transplant” with Schoenhaus R, Awdishu L. Presented at ISPOR 13th Annual Internationsl Meeting, May 5, 2008, Toronto, Canada.

“ Use of an Inter-Hospital Benchmark Tool Before and After Implementation of Bar-code Medication Administration” with Helmons P and Wargel L. Presented at AHSP Midyear Clinical Meeting, December 9, 2008, Orlando FL.

Daniels CV Page 10

“Quality Assessment of Drug Therapy by Pharmacy: Finding and using drug use metrics”. Presented at Dubai International Pharmaceuticals and Technologies Conference (DUPHAT 2009), March 31, 2009, Dubai, UAE.

“Use of the Clinical Resource Manager to analyze UHC’s Inpatient Drug Expense / Pharmacy Intensity-Weighted Discharge Key Indicator Report” with Helmons P. Presented at University Health System Consortium, December 4, 2009, Las Vegas NV.

“Implementation of a nonformulary monitoring system” with Helmons P. Presented at the International Society of Pharmacoenconomics and Outcomes Research Annual International Meeting, Atlanta GA, May 13, 2010.

“Analysis of North American hospital systems for medication-use process: underlining key points to improve patient safety among French hospitals” with Brouard P, and Fagon JY. Presented at the Second International PSIP Workshop: Patient Safety through Intelligent Procedures in Medication. Paris, France May 16, 2011. Published in Studies in Health Technology and Informatics: 2011; 166:148-55.

“Improved Formulary Compliance by Implementing a comprehensive formulary management system” with Helmons P. Presented at ASHP Midyear Clinical Meeting, December 2, 2012, Las Vegas, NV.

“Pharmacist-managed care of patients with heart failure throughout the hospital to home transition” with Jarrell A, and Schlueter M. Presented at Optimizing Pharmacy Education and Training. Riyadh, Kingdom of Saudi Arabia, February 25-26, 2013.

“Development of Live Continuing Education Programs for Pharmacy Technicians” with Amar Sharma. Presented at ASHP Midyear Clinical Meeting, December 7, 2015, New Orleans, LA.

“Interrater agreement among healthcare provers in categorizing medication errors using medication-use process nodes” with NT Yam, JK Hwang, and FK Yam. Presented at ASHP Midyear Clinical Meeting, December 6, 2016, Las Vegas, NV.

INVITED PRESENTATIONS AND PUBLICATIONS

Daniels, C.E. and Tangrea, J.A. Use of Patient-Oriented Drug Data Sheets in Counseling Patients Before Discharge. Hospital Pharmacy. 1977; 12:230-237.

"How to Lie with Statistics". Invited Lecture to the Section of Teachers of Clinical Pharmacy of AACP and ACCP, New Orleans, LA. December 5, 1981.

"The Hospital Formulary System", at Pharmacy and Medical Staff Conference, Saint Vincent Medical Center, Portland, OR, August 10, 1984.

Daniels CV Page 11

"Pharmacy Inventory Management in the 1980's", for Health Central Inc. Annual Bid Group Meetings, Brooklyn Center, MN, March 12, 1984.

"Managing Pharmacy Inventory", at State of Minnesota Pharmaceutical Bid Group Meeting, St. Paul, MN, April 3, 1985.

"Basics of Inventory Management", for Managers and Assistant Managers of Erickson's Value Drug Stores. Hudson, WI, November 7, 1985.

"Pharmacy Issues Involving the Control and Distribution of Tissue Plasminogen Activator and Similar Drugs", at the meeting of the New England Council of Hospital Pharmacists, Boston, MA, March, 24, 1987.

Daniels, C.E. Therapy with Intravenous Immune Globulin. Minnesota Pharmacist. 1989; 43(6):18-21.

"Automation of Pharmacy Services and Information", at the Annual Carolina Seminar, Greensboro, NC, September 20, 1989.

Daniels, C.E. Planning and Organizing for Clinical Pharmacy Services, Part I. Dynamics in Health Care. 1990 (Aug); 1(4): 9-11.

Daniels, C.E. Planning and Organizing for Clinical Pharmacy Services, Part II. Dynamics in Health Care. 1990 (Nov); 2(1): 6-9.

"IV Immune Globulin: A Case Study", at the UHC Technology Information Service Seminar, Oak Brook, IL, November 3, 1990.

"Floor Stock Drug Tracking Using Bar-Code Technology", at the University Hospitals Consortium Seminar on the Impact of Automation on UHC Departments of Pharmacy, Itasca, IL, March 23, 1991.

"Career Development/Career Tracking Workshop", (with D. Swartwood) MSHP Annual Meeting, Minnetonka, MN, April 13, 1991.

“Accepting the Challenge--Building the Foundation for Quality Clinical Services”, Cleveland, OH, September 13, 1991, and Miami, FL February 4, 1992

Daniels, C.E. Peer Review as a Quality Improvement Tool. Dynamics in Health Care. 1992 (Aug); 3(4): 3-5.

“Using Key Medication Therapy Activity Variances in Performance Improvement“, PROPP Summer Institute on Measuring Quality of Pharmaceutical Use and Practices in Managed Care, Seattle, WA, July 27, 1997.

Daniels CV Page 12

“Medication Misadventure Data Analysis that Works”, PROPP Summer Institute on Measuring Quality of Pharmaceutical Use and Practices in Managed Care, Seattle, WA, July 28, 1997.

“Medication Errors Monitoring”, Howard University School of Pharmacy, Washington, DC, April 7, 1998.

“Pharmacy Services at the National Institutes of Health”, University of Minnesota Graduate School Seminar, Minneapolis, MN, April 23, 1998.

“1999 Chemotherapy To Do List: Expert Advice”, Institute for Safe Medication Practices Midyear Program, Las Vegas, NV December 8, 1998.

“Methodology for Evaluating Pharmacoeconomics Studies”, Teaneck, NJ. May 12, 1999, and Atlanta, GA, May 12, 1999. Later developed as a stand-alone CE program on CD-ROM for distribution through the Academy of Managed Care Pharmacists.

“Designing a Pharmacoeconomics Study: a workshop for managed care pharmacists” Teaneck, NJ. May 12, 1999.

“New Developments in Pharmaceutical Research at the National Institutes of Health: Exploring the Possibilities for Medicine”, Academy of Managed Care Pharmacist Fall Educational Conference, Atlanta, GA, October 8, 1999.

“2000 Chemotherapy To Do List: Expert Advice”. Institute for Safe Medication Practices Midyear Program, Orlando, FL, December 6, 1999.

Motheral, BR, Cox ER, Daniels CE. Pharmacoeconomics and Outcomes Research: Evaluating the Studies. Journal of Managed Care Pharmacy. 2000; 6 (1) Supplement: 4 – 15.

“Safe Use of Medications”, Pharmacotherapy Frontiers 2000, National Institutes of Health, Bethesda, MD, April 8, 2000.

“Practical Use of Pharmacoeconomic Literature”. Spring Educational Meeting, Florida Society of Health-Systems Pharmacists, Ft. Lauderdale, FL, April 14, 2000.

“2001 Chemotherapy To Do List: Expert Advice”. Institute for Safe Medication Practices Midyear Program, Las Vegas, NV, December 6, 2000.

“2002 Chemotherapy To Do List: Expert Advice”. Institute for Safe Medication Practices Midyear Program, Las Vegas, NV, December 3, 2001.

“Accreditation and Standards of Practice of Hospital Pharmacy”. Committee on Hospital Pharmacy, Prague, Czech Republic, February 9, 2002.

“The Pharmacist and Clinical Research at the National Institutes of Health”. College of Pharmacy, Florida A & M University, Tallahassee, FL, February 25, 2003.

Daniels CV Page 13

“Quality Measurement of Medication Use”. Grand Rounds at King Hussein Cancer Center, Amman, Jordan, October 13, 2003.

“Impact of Supply Chain Issues in the Medical Center”. ASHP Midyear Meeting, December 6, 2004, Orlando, FL.

“Do You Have and MP3 Residency? Multisite, Multiprogram, Multiresident”, National Residency Preceptor Conference, August 17-19, 2006, Washington DC.

“Quality Assessment of Drug Therapy”, NIH Course on Principles of Clinical Pharmacology. Presented each year at NIH Clinical Center, Bethesda, MD.

Daniels CE. Hospitalist-pharmacist collaboration: Only natural. Am J Health-Syst Pharm.. 2008; 65:207.

“Training Residents to Teach: Pharmacy Practice Experiences”, National Residency Preceptor Conference, August 15 & 16, 2008, Washington DC.

“Implementation Challenges in Hospital Pharmacy Introductory Pharmacy Practice Experience Programs”. University Health System Consortium Pharmacy Council Meeting. December 6, 2008, Orlando FL.

“Framing Speaker: Finance” Pharmacy Leadership Summit, University of California San Francisco, March 16, 2009, San Francisco, CA.

“Building the Foundation for Transition into a Supervisory Role”, American College of Clinical Pharmacy Spring Practice and Research Forum. April 24, 2010, Charlotte, NC

“Marketing Your Residency: Standing Out In A Sea of Options” National Residency Preceptor Conference, August 20, 2010, Washington DC.

“Residents as Integral Components of the Care Model”. ASHP Midyear Meeting, December 7, 2011, New Orleans, LA.

“Practical Application of Social and Behavioral Pharmacy Principles in a Hospital Pharmacy Practice”, First Ibero-American Symposium on Social Pharmacy. June 22, 2012, Mexico City, Mexico.

“Pharmacy Residents as a Key Component of Our Pharmacy Practice Model” National Residency Preceptor Conference, August 15, 2012, Washington DC.

“Bioethical Issues and Drug Shortages Panel” Bioethical Issues in Pharmacology-Bioethics Education Series, Rady Children’s Hospital-San Diego, October 12, 2012, San Diego, CA.

Daniels CV Page 14

“Framing a Pharmacist Role in Transitions of Care” San Diego County Pharmacy Leaders Breakfast-Current Issues in Transitions of Care, November 7, 2012, La Jolla, CA.

“Transitions of Care: Future Residency Opportunities?” Speaker and panel moderator. ASHP Midyear Meeting, December 2, 2012, Las Vegas, NV.

“Pharmacist Scope of Practice Barriers” Center for Health Quality and Inovation Governing Board, University of California Office of The President. December 14, 2012, Oakland, CA.

“Pharmacy Careers Workshop” Catch the Wave to Success San Diego State University Pre- Professional Health Conference, February 23, 2013, San Diego, CA.

“Prescribing Issues on the Health System Horizon” San Diego Health System Pharmacy Executives Spring Symposium, May 21, 2013, La Jolla, CA.

“Pharmacist Program to Improve Patient Outcomes Through Transitions from Hospital To Home”. Second Iberoamerican Symposium on Social Pharmacy. September 26, 2013, Mexico City, Mexico.

“The Importance of Leadership in Driving Transformational Events in Hospital Pharmacy Practice: A 30-Year Reflection of Webb Awardee Lectures”. ASHP 49th Midyear Meeting, December 9, 2014. Anaheim, CA.

Daniels CE. “Who Will Sit In My Chair”. John W. Webb Lecture, October 27, 2014 Northeastern University, Boston, MA. and at ASHP Leadership Conference, October 21, Chicago, IL. Am J Health-Syst Pharm. 2015; 72:657-62.

Daniels CE. “Residency Standards: Highlights of the New Residency Accreditation Standards”. California Society of Health-System Pharmacists Annual Seminar, October 8, 2015, San Diego, CA.

Daniels CE. “Pharmacy Department: An administrative perspective”. Pharmacy Grand Rounds, Massachusetts General Hospital, October 24, 2016.

Daniels CE. “Biosimilars: Are we there yet?” Applied Pharmacoeconomics and Outcomes Forum, San Diego, CA, February 6, 2017.

Daniels CE. Reflections on the Pharmacy Technician Stakeholder Consensus Conference. Dallas TX, February 16, 2017.

Daniels CV Page 15

Daniels CE. Residency Training Programs: Laboratories for innovation. Am J Health-Syst Pharm.. 2017; 74 (6) 369-370; DOI: https://doi.org/10.2146/ajhp160949

Daniels CE. “Create Your Future!” ASHP Visiting Leaders Program, The Florida Hospital System, Orlando, FL. March 28, 2017.

Daniels CE. “Your Future in Health System Pharmacy” ASHP Visiting Leaders Program, The Children’s Mercy Hospital, Kansas City, MO. November 18, 2017.

Daniels CE. “340B Primer” UC Health Government Relations Group. San Diego, CA. January 23, 2018. San Diego CHIP Public Policy Committee, San Diego, CA. March 1, 2018.

Daniels CE. “Quality Assurance for Drug Therapy“, Module 7, Session 7 in NIH Clinical Center Principles of Clinical Pharmacology. https://www.youtube.com/watch?v=mi- 5vcSPQsg&list=PLokeFpXsus967pMXfJ406ECFK9ANmSqEc&index=49 Accessed 2/18/2018.

Daniels CE, w/Shane R. “Why Leadership is a Clinical Specialty” ASHP Podcast Series March 5, 2018.

Daniels CE. “Organized and Nearly-Organized Thoughts on the Future of Pharmacy in Health Systems”. ASHP Visiting Leaders Program, The Johns Hopkins Hospital, Baltimore, MD, March 30, 2018.

Daniels CE. “Residencies: Getting bigger for all new pharmacists”. Western Pharmacy Exchange, San Diego, CA. April 13, 2018.

BOOKS AND BOOK CHAPTERS

Daniels, C.E. Recruitment and Selection. Hospital Pharmacy Human Resources Management, M. Noel and J.L. Bootman editors. Rockville, MD. Aspen Corporation, 1985.

Daniels, C.E. The Pharmacy and Therapeutics Committee and Formulary System. Handbook of Institutional Pharmacy Practice, Second Edition, M.L. Smith and T.R. Brown editors. Baltimore, MD. Williams and Wilkins, 1986.

Daniels, C.E. and Giese, R.M. Evaluating Prime Vendor Programs. Handbook of Hospital Pharmacy Prime Vendor Programs, S. Murphy-Enright editor. New York, Pfizer.

Daniels, C.E. Purchasing and Inventory Control. Manual for Administration of Hospital Pharmacies, A.I. Wertheimer and C.E. Daniels editors. Washington, DC. Pan American Health Organization, 1989.

Daniels CV Page 16

Daniels, C.E. Pharmacy Outcomes Measures. Social and Behavioral Aspects of Pharmaceutical Care, Smith and Wertheimer Editors. Binghamton, NY. The Hayworth Press, Inc., 1996. Spanish language edition published in June 2012.

Daniels, C.E. Pharmacoeconomics. Pharmacology for the Primary Care Provider, Edmunds and Mayhew Editors. St. Louis, MO. Mosby, Inc., 2000.

Calis KA and Daniels CE. National Institutes of Health. DiPiro’s Encyclopedia of Pharmacy Resources. New York, Marcel Dekker Inc. 2002.

Daniels, C.E. Quality Assessment of Drug Therapy. Principles of Clinical Pharmacology, Atkinson, Daniels, et al Editors. Academic Press, 2001. Second edition, 2006. Third Edition Elsevier, 2012.

Daniels CE. Hospitals and Health Care Institutions. Pharmacy and the U.S. Health Care System. Smith, Wertheimer, Fincham Editors, Third Edition. Binghamton NY, Pharmaceutical Products Press, Inc. 2005. Fourth edition (with S. VanOsdol) 2013.

Daniels, CE. International Residency Training Opportunities. Roadmap for Postgraduate Training in Pharmacy (Bookstaver, Smith, Miller, et al, Editors), McGraw-Hill, 2013.

REVIEWS, LETTERS, AND OTHER PUBLISHED COMMUNICATIONS

Daniels, C.E. Drugs and Clinical Trails. American Pharmacy. 1979; NS 19:284.

Daniels, C.E. Effect of Control Programs on Cefazolin Prescribing. Am J Hosp Pharm. 1980; 37:24, 26.

Book Review Self Medication. The Proceedings of the Workshop on Self-Care, Anderson J.A.D. MTP Press Ltd, Lancaster, U.K. 1979. For Pharmacy International. 1980; 1 (June):XII.

Daniels, C.E. Pharmacist Hero Found. Am J Hosp Pharm. 1982; 39:583.

Roberts, M.J., Summerfield, M. and Daniels, C.E. Oral Cephalosporin Prescribing Unchanged After Pharmacy Newsletter. Am J Hosp Pharm. 1982; 39: .

Book review The Rights of Doctors, Nurses and Allied Health Professionals: A Health Law Primer, Annas, G.J., Glantz, L.H. and Katz, B.F. Avon Books, New York, 1981. For American Journal of Hospital Pharmacy. 1982; 39:186.

Book review Unit Dose Primer, Summerfield, M.R. American Society of Hospital Pharmacists, Bethesda, MD, 1983. For Am J Hosp Pharm. 1984; 41:1028,1033.

Fletcher C, Daniels C.E. Monitoring Drug Utilization. Hospital Formulary. 1987; 22:195.

Daniels CV Page 17

Book review How to Evaluate Progressive Pharmaceutical Services, McKay, A.B., Hepler, C.D., and Knapp, D.C. ASHP Research and Education Foundation, Bethesda, MD, 1987. For Am J Hosp Pharm. 1988; 45:2445.

Calis KA, Daniels CE. Safety Reporting in Clinical Trials. JAMA. 2001; 285:2076

PROFESSIONAL ACTIVITIES AND SERVICE

American Society of Health-System Pharmacists: Delegate to multiple ASHP House of Delegates; Review Panel for Administrative Grant Program, 1986, 1987 & 1989; Reviewer for Annual Meeting and Midyear Meeting Contributions; Management Certificate Program, Productivity Module Design Team; Research Awards Selection Panel, 1989-1995; Advisory Committee on the USP, 1993- 1995; Board of Canvassers, 1996-2001 (chair, 2000-01); Council of Organizational Affairs, 1985-86; IV Safety Summit Participant, July 14-15, 2008, Rockville MD; Pharmacy Practice Model Initiative Summit, November 7-9, 2010, Dallas, TX. Commission On Goals, 2014; Planning Committee, Leadership Conference, 2015; Chair, Webb Selection Committee, 2015 and 2016.

Residency Accreditation Surveyor; Working Group on Administrative Residencies and Fellowships, 1984-85; Commission on Credentialing, (August 2004-10); Chair 2006-10; Accreditation Surveyor Workshop Group Leader, December 2008; Pharmacy Residency Capacity Stakeholders Conference, February 2011, Washington DC; First International Accreditation Survey Team, 2008; International Residency Advisory Group, 2016; International Accreditation Commission, 2016-current. Pharmacy Forecast Advisory Committee, 2018. Pharmacy Technician Accreditation Council, 2018-.

Accreditation Council for Pharmacy Education SIAPS Partner Meeting: Defining and Measuring Pharmaceutical System Strengthening. ACPE Representative September 11-12, 2014. Pharmacy Technician Consensus Conference Stakeholder Advisory Committee, 2016-17.

State or Regional Professional Organizations Minnesota Society of Hospital Pharmacists: Organizational Affairs Council, 1981-83, 1985-86; Long Range Planning Committee, 1982-84 (Chair); Board of Directors, 1986-89; Annual Meeting Planning Committee, 1983-84; Administrative Affairs, 1984-85, 1987-91; Drug Management Committee, 1986-87; Joint Annual Meeting Task Force, 1990; Clinical Affairs, 1991-92; Legal and Public Affairs, 1992-95 (Chair). Central Minnesota Society of Hospital Pharmacists, Treasurer, 1983-84. Washington (DC) Metropolitan Society of Health-System Pharmacists Nominations Committee Chair 1998-2003 California / San Diego Society of Health System Pharmacists: California Department of Public Health Hospital Medication Survey Process;

Daniels CV Page 18

Program Planning Committee for Seminar 2009 Pharmacy Practice Model Initiative Task Force, 2012 - 2014

American Association of Colleges of Pharmacy: National Health Careers Explorers Exposition, Session Coordinator, August, 2002 & August, 2003, Bethesda, Maryland Professional Affairs Committee 2006-07 Representative to the Council of Deans 2009-11

American College of Clinical Pharmacy: Technology Support Task Force, 2006-07 Task Force on Residencies, 2010-11

International Society of Pharmacoeconomic and Outcomes Research: Research Excellence Award Task Force, 2001-03

National Institutes of Health: Clinical Pharmacology Steering Committee, and Clinical Pharmacology Core Curriculum Advisory Group, 1997-2004 Institutional Review Board, National Institute of Dental and Craniofacial Research, 1996- 2000; Institutional Review Board, National Heart, Lung and Blood Institute, 2001-2004;

Speaker, Arthur Ashe Institute for Urban Health Science Academy, 2002.

Scientific Review Group ZA 1-AW-06-05 NIAID Clinical Research Products Management Center, August, 2005

Scientific Review Group 2013/01 ZAI1 KP-A (C1) 2 NIAID Clinical Research Products Management Center, December, 2012

Health Services Organization and Delivery Study Section Reviewer, 2007, 2014 & 2015

Clinical Center Pharmacy Chief Search Committee, Non-voting Member, 2016.

Editorial Board Member, American Journal of Hospital Pharmacy, 1983-95; Journal of Managed Care Pharmacy, 1998-2000; Oncology Spectrums, 2000-2002; Contributing Editor, International Pharmaceutical Abstracts, 1979-1983.

Northeast Metro Technical College, Maplewood, MN, Pharmacy Technician Advisory Board Member, 1990-1993.

Data Monitoring Board for VA Cooperative Study #475-Antibiotic Treatment of Gulf War Veterans’ Illnesses, 1999-2002

University Health System Consortium Pharmacy Wholesaler and Distributor Committee, 1987-1991, Bundled Proposals Committee, 1992-95, Pharmaceutical Award Committee, 1987-95.

Daniels CV Page 19

Research and Education Committee, 2005-ongoing Pharmacy Council Executive Committee, 2007-09

Novation Pharmacy Executive Council, 2009-14.

State of California Department of Health and Human Services: Let’s Get Healthy California, Grant Development Task Force; Workgroup on Redesigning Health System: Efficient, Safe, and Patient Centered Care, 2013.

Center for Pharmacy Practice Accreditation: Accreditation Committee 2016-18; Specialty Standard Subcommittee 2018;

Acentrus Specialty Pharmacy Advisory Council 2017-8.

America’s Essential Hospital 340B Committee 2017-18

American Hospital Association Task Force on 340B Drug Pricing Program, 2018.

Daniels CV Page 20

University of California: 2004-ongoing Skaggs School of Pharmacy and Pharmaceutical Sciences Advisor to student chapter of American Society of Health-System Pharmacists Committee on Academic Personnel 2006-2015 Student Research Project Committee 2009-2010 Ad Hoc Committee for Pharmaceutical Care Incentives and Compensation 2010 Committee on Educational Policy 2009-2017 Volunteer Faculty Review Ad Hoc Committee since 2015

Health Sciences Review Panel for Department Chair in Reproductive Medicine VA Affiliation Partnership Council 2005-2010 VMRF Inquiry Committee Biomedical Library Advisory Committee 2007-2011 Committee on Planning and Budget 2010-12 Strategic Planning Multi-campus Geographic Footprint Design Team, 2013

UC San Diego Health System Medical Board of Governors since 2005 Medical Staff Executive Committee since 2005 Medical Staff Quality Council since 2009 Pharmacy and Therapeutics Committee (co-chair) since 2004 Safe Medication Practices Committee since 2009 Patient Safety Committee since 2010 Governance Advisory Council 2009-2015

National Institutes of Health Clinical Center: 1995-2004 Clinical Center Pharmacy & Therapeutics Committee, 1995-2004. Clinical Center MEC Patient Safety Committee, 2003-04.

Decision Support System Steering Committee, 1997-98; Clinical Center Information Technology Advisory Group, 1998-2000; Clinical Research Information System Stakeholder Advisory Committee, 2000-2004; Redesign and Computerization of Protocol Mapping Steering Committee, 1999; Clinical Center Medical Board Information Systems Committee, 1995-1999; Clinical Center Performance Measurement Steering Committee, 1998-2001

Personnel Demonstration Project Advisory Committee & Chair of Compensation Subcommittee Chair (1996); Performance Measurement Development Team (Chair), 1996-98; NCI, Biological Response Modifiers Operating Committee, 1996-99. Consultant to the Protocol Coordination Services Center, since 1996; Decision Support System Steering Committee, 1997-98; Institutional Review Board, National Institute of Dental and Craniofacial Research, 1996-2000; Clinical Center Information Technology Advisory Group, 1998-2000; Redesign and Computerization of Protocol Mapping Steering Committee, 1999; Y2K Prep Team, 1999-2000; Clinical Center Medical Board

Daniels CV Page 21

Information Systems Committee, 1995-1999; Clinical Center Performance Measurement Steering Committee, 1998-2001;

University of Minnesota: 1980-1995 University of Minnesota Graduate School Health Sciences Policy and Review Council, 1981-1992; Faculty Nominations Committee, 1981-92; Program Evaluation Committee, 1986-89.

University of Minnesota College of Pharmacy Admissions Committee, 1982-83, 1983-84; Task Force on College Organizational Structure, 1982; Administrative Advisory Council, Spring, 1983; Honors Oversight Committee, 1983-84, Chairperson 1986-87; General Research Support Committee, 1984 – 1990; Executive Committee, 1984-85; Review Committee: Continuing Education in Pharmacy, 1986-87; Review Committee: Graduate Management Training in Pharmacy, 1988; Pharmacy Practice Executive Committee, 1990. Guest class leader for Institutional Pharmacy Management, May 4, 2018 (remote participation).

University of Minnesota Hospital and Clinic Pharmacy and Therapeutics Committee, 1981-95, Blood Derivative Subcommittee, 1987-94, Antibiotic Subcommittee, 1989-94; Nutrition Support Subcommittee, 1989-95; Purchasing System Advisory Committee, 1983-86; Pharmacy-Nursing Cost Containment Task Force, 1985; Nursing-Pharmacy Committee, 1986-95; Materials Distribution Task Force, 1988-91; Home IV Therapy Work Group, 1989- 1990; Purchasing System Task Force, 1990-1991; Biomedical Ethics Committee, 1989-94; Materials Distribution System Group, 1989 to 1992; Purchased Goods and Services Task Force, 1992.

Date Prepared: 12/15/2018 Name: Robert El-Kareh Office Address: UCSD Div of Biomedical Informatics 9500 Gilman Dr., #0881 La Jolla, CA 92093-0881

Work Phone: 858-822-7776 Work Email: [email protected] Work FAX: 877-664-8494 Place of Birth: Burlington, Vermont

Education

1992 BS Electrical Engineering Stanford University, Stanford, CA 1995 MS Electrical Engineering Stanford University, Stanford, CA 2003 MD Medicine Temple University, Philadelphia, PA 2009 MPH Clinical Effectiveness Harvard University, Boston, MA

Postdoctoral Training

06/03-06/06 Resident Internal Medicine Brown University, Providence, RI 07/06-06/07 Chief Resident Internal Medicine Brown University, Providence, RI 07/07-06/10 Research Fellow Medical Informatics Brigham & Women's (David Bates, MD MSc) Hospital, Boston, MA

Faculty Academic Appointments

07/16- Associate Professor Medicine UC San Diego 07/10-06/16 Assistant Professor Medicine UC San Diego

Appointments at Hospitals/Affiliated Institutions

07/10- Attending Physician Medicine UCSD Medical Center, Division of Hospital Medicine San Diego, CA 04/08-06/10 Fee Basis Attending Medicine VA Medical Center, Providence, RI

Major Administrative Leadership Positions Local 2011- Course Director, Intro to Clinical UC San Diego, Department of Medicine Environments

Committee Service Local 2018- Graduate Programs Education Committee, UCSD Chair 2016- Clinical Decision Support Oversight UCSD Committee, Chair 2016-2018 Graduate Programs Education Committee, UCSD Member 2014-2016 Lab Utilization Committee UCSD 2013- Medication Reconciliation Committee, UCSD Chair 2012- Transitions of Care Steering Committee UCSD 2011- Biomedical Informatics Curriculum UCSD Committee 2011-2012 Bioinformatics Research Rotations UCSD Committee 2010- Quality Council UCSD 2006-2007 IM Residency Redesign Committee Rhode Island Hospital 2006-2007 Medical Clinic Committee Rhode Island Hospital 2006-2007 Code Review Committee Rhode Island Hospital 2006-2007 Council of Chiefs Rhode Island Hospital 2006-2007 Code Review Committee Miriam Hospital 2005-2007 Med Reconciliation Committee Rhode Island Hospital

Professional Societies 2017- Society to Improve Diagnosis in Medicine Chair, Research Committee 2014-2017 Society to Improve Diagnosis in Medicine Co-Chair, Research Committee 2013-2014 Society to Improve Diagnosis in Medicine Member, Research Committee 2010- Society of Hospital Medicine 2016-2017 Member, IT Committee 2010, 2011, Diagnosis Error in Medicine Conference Member, Conference Planning Committee 2013- 2009- American Medical Informatics Association 2008-2010 Society of General Internal Medicine 2007-2008 American Medical Association 2004-2007 American College of Physicians

Editorial Activities Ad Hoc Reviewer: Journal of the American Medical Informatics Association Annals of Internal Medicine 2

Journal of Hospital Medicine Computers in Biology and Medicine Diagnosis BMJ Open BMJ Quality and Safety Journal of General Internal Medicine

Honors and Prizes

2018 Best Practice Diagnosis in Medicine Conference Improvement Poster 2017 Kaiser Excellence in UC San Diego Teaching third-year Teaching Award medical students Nominee 2014 Top Reviewer Annals of Internal Medicine 2013 Top Reviewer Annals of Internal Medicine 2009 Lipkin Finalist SGIM Top oral abstracts by trainees 2008, 2009 Plenary speaker Boston-area Informatics Research Selected to present oral Training Program abstract at NLM fellows' conference 2007 Haffenreffer Fellow Rhode Island Hospital Performance as resident

Report of Funded and Unfunded Projects Funding Information Past

2016-2017 Learning From Triggered Events about Diagnosis (LIFTED) University of California Professional Medical and Hospital Liability Program PI ($151,800) This project seeks to use objective criteria to screen for diagnostic errors, conduct a review panel to analyze the contributing factors to these errors, and provide feedback to implement risk-reducing interventions.

2016-2017 Collaborative Research: Unobtrusive Sensing and Motivational Feedback for Family Wellness NSF/1622626 Investigator (PI: Huh) This project is to design, develop, and evaluate an innovative family routine sensing and feedback system called FRESH (Family Routine, Education, and Sensing Health), which empowers families to actively engage in preventing child obesity and improving family wellness.

2013-2016 Minimizing Physician Errors: Feedback of Patient Outcomes After Handoffs NIH/ K22 LM 011435-01 - NCE

PI ($538,500) The goal of this project is to improve physician diagnostic performance by developing and testing an electronic system to provide systematic feedback regarding the outcomes of patients they have cared for and handed off to other providers.

2013-2016 Quality Improvement Grant, UC Center for Health Quality & Innovation Torriani, Francesca (PI) Developing Standardized Operative Bundles to Decrease Surgical Site Infections (SSI) The goal of this project is to reduce SSIs in orthopedic and neurosurgical patients at each UC health system in one or more of the following procedures: total knee replacements, total hip replacements, laminectomies, spinal fusions, and colorectal surgeries.

2010-2016 U54 HL108460, NHLBI Ohno-Machado, Lucila (PI) iDASH: Integrating Data for Analysis, Anonymization and Sharing The major goal of this project is to decrease the gap and accelerate discoveries by providing innovative services, algorithms, open-source software, infrastructure, and training to facilitate data analysis and exchange between biomedical researchers.

2014-2015 UC Center for Health Quality & Innovation Investigator (PI: Elisa Tong) Project to develop a University of California-wide tobacco cessation program that will include an electronic interface with the California Smokers Helpline.

2011-2015 iDASH: Integrating Data for Analysis, Anonymization and Sharing NIH/ U54 HL108460 Investigator (PI: Lucila Ohno-Machado) The major goal of this project is to decrease the gap and accelerate discoveries by providing innovative services, algorithms, open-source software, infrastructure, and training to facilitate data analysis and exchange between biomedical researchers.

2011-2013 SCANNER: Scalable National Network for Effectiveness Research AHRQ/1R01 HS019913-01 Investigator (PI: Lucila Ohno-Machado) The goal is to develop new strategies and tools to allow secure and privacy-protecting electronic health information exchange for research.

2010-2013 Improve the Rate of Appropriate Drug Dosing in Patients with Renal Impairment UCSD Health Sciences Risk Management & Patient Safety Program/Patient Safety Grant Investigator (PI: Linda Awdishu) The goal of this project is to reduce delays in adjusting medications appropriately for renal dysfunction through the effective use of a health information technology intervention.

2008-2009 Antibiotic Coverage in Post-Discharge Culture Results CRICO/Risk Management Foundation/ Patient Safety Research Grant PI ($45,433) The goals are to implement and study a system to automatically alert both inpatient and

outpatient clinicians if untreated microbiology cultures return on their patients after they are discharged from the hospital.

2008-2009 Using Feedback to Close the Loop on Diagnosis Errors at Brigham and Women’s Hospital and Clinics CRICO/Risk Management Foundation/ Patient Safety Research Grant Investigator (PI: Gordon Schiff) This project is designed to investigate causes and contributing factors for diagnosis errors. In addition, we intend to provide “upstream” feedback of these errors to clinicians involved in the case.

2004-2007 Improving Safety and Quality with Outpatient Order Entry AHRQ/1R01 HS 015226-01 Investigator (PI: Tejal Gandhi) This project investigates the impact on quality of care, patient safety and clinician workflow of linking ambulatory computerized order entry with clinical decision support systems. Current

2017- Post-Handoff Report of Outcomes 2 (PHAROS2) Gordon and Betty Moore Foundation Principal Investigator Through a mixed-methods evaluation, this project aims to identify the most effective means of providing post-handoff feedback of patient outcomes to providers. We will iteratively improve the design of a system to deliver provider-specific reports of patient outcomes and will disseminate its use.

2017- Decentralized Differentially-Private Methods for Dynamic Data Release and Analysis NIH/1R01 GM 118609 Investigator (PI: Jiang) This project aims at designing and implementing differentially-private decentralized methods for dynamic data dissemination and analysis. We plan to use genomic and clinical data from both public domain and local institutions (UCSD and Emory) to carefully evaluate the feasibility and efficiency of our proposed new methods.

Current Unfunded Projects

2015- Quantifying the Clinical Cascade of Diagnostic Tests This project is a retrospective analysis of diagnostic tests with the goal of modeling the frequency of subsequent test ordering that occur as a result of initial test results.

2015- Reducing Unnecessary Daily Labs Through Provider-Specific Reports The goal of this project is to develop provider-specific reports to provide feedback of daily lab ordering and comparison of provider against peer group to promote more rational diagnostic test ordering.

Report of Local Teaching and Training Teaching of Students in Courses

2018 Practice of Medicine 2 UCSD School of Medicine 1 hour lecture

2012, 2017 Current Trends in Biomedical Informatics UCSD School of Medicine 1 hour lecture

2015- Informatics in Clinical Environments UCSD School of Medicine Biomedical Informatics Researchers Course Director

2015- Intro to Biomed Natural Language Proc. UCSD School of Medicine Medical students and researchers 1.5 hour lecture

2012- Principles of Biomedical Informatics UCSD School of Medicine Biomedical Informatics Researchers 2 hour lecture

2012- Data Management and Informatics for UCSD Clinical Research Enhancement Clinical Research through Supplemental Training 2nd year medical students 2 hour lecture

2012-2014 Pharmacy Informatics UCSD School of Pharmacy 1st year pharmacy students 2 hour lecture

2011- Introduction to Clinical Environments UCSD School of Medicine Biomedical Informatics Researchers Course Director

2011- Epidemiology, Biostatistics and Medical UCSD School of Medicine Informatics medical students 2 hour lecture

2011-2016, From Principles to Practice UCSD School of Medicine 2018 4th year medical students 3.5 hours

2007-2008 Patient-Doctor I Harvard Medical School 1st year medical students 2 hours/wk for full academic year

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 2018 Medication Reconciliation / Internal UCSD Medicine Interns 1 hour lecture

2018 Use of Health Information Technology to UCSD Reflect on and Improve Clinical Decision- 1 hour lecture Making / Surgery Residents

2017 Preparing Effective M&M Conferences / UCSD Internal Medicine Residents 1 hour lecture

2014 Improving our Diagnostic Skills Through UCSD Outcome Feedback/Resident Noon 1 hour lecture Conference

2013 Diagnostic Errors and Some Possible UCSD Interventions/Resident Noon Conference 1 hour lecture

2011 Fluids and Electrolytes UCSD 4th year medical students 1 hour lecture

2010 Diagnosis Errors UCSD 3rd year medical students 1 hour lecture

Clinical Supervisory and Training Responsibilities

2010- Inpatient teaching attending/UCSD 4-9 weeks/year 2006-2007 Ambulatory clinic preceptor/Rhode Island 10 half-day sessions Hospital

Local Invited Presentations 2018 Adding Quality Improvement to Your Academic Portfolio UCSD Faculty Development Workshop

2018 Strategies to Recognize and Learn from Opportunities to Improve Diagnosis Division of Hospital Medicine Grand Rounds, UCSD

2016 Improving the Safety and Accuracy of Diagnosis: From IOM to UCSD Department of Medicine Grand Rounds, UCSD

2016 Using Information in Clinical Settings UC San Diego Health Sciences International Bridge to Residency Program, UCSD

2013 Using Big Data to Personalize Medicine / Bioscholars Seminar Division of Biological Sciences, UCSD

2012 My Take on the MD/MPH Combo UCSD Health and Medical Professions Preparation Program

2012 Medication Reconciliation in an EMR: New Solutions and Some New Problems UCSD Patient Safety Conference

2011 Helping Physicians Improve Care with Clinical Decision Support / Progress in Medical Research (PRIMR) Lecture Series Department of Medicine, UCSD

2009 Diagnosis Errors: Can Informatics Help? / Informatics Seminar Series Division of Biomedical Informatics, UCSD

Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses National 2018 Integrating Technology and Decision Support into Medical Education / Co-presenter in conference pre-course Diagnostic Error in Medicine 11th International Conference; 2018; New Orleans, LA.

2018 Diagnostic Error: How to Approach It Without Being Punitive. / Co-presenter in conference workshop Hospital Medicine 2018, Orlando, FL

2014 Improving Our Treatment of Infections: Making “Empiric Antibiotics” More Empirical Mathematical Modeling Summit, University of Utah, Salt Lake City, UT

Report of Clinical Activities and Innovations Current Licensure and Certification

2015 Clinical Informatics, Diplomate 2010 California Medical License 2008 Federal Controlled Substance Registration 2007 American Board of Internal Medicine, Diplomate

Practice Activities

2010- Inpatient Medicine Hospital medicine, UCSD 5-10 weeks/year 2008-2010 Emergency Department Emergency Department, VA 3-6 12-hour shifts/month Providence, RI

Clinical Innovations Automated alerting Designed, implemented and studied an automated, email-based alerting system to system for post- notify inpatient and outpatient providers about important microbiology culture discharge results that returned after hospitalized patients were discharged. This system was microbiology results deployed at Brigham and Women's Hospital, Boston, MA

Report of Education of Patients and Service to the Community Activities

2017-2018 Society to Improve Diagnosis in Medicine/Research Mentor (PCORI) 8

Served as a research mentor in project to train patients to become partners in diagnostic safety research.

2012 Best Doctors / Panel Member Physician Panel: Linking Inappropriate Testing and Diagnostic Error

Report of Scholarship Publications

Peer reviewed publications in print or other media

Research investigations

1. El-Kareh R, Gandhi TK, Poon EG, Newmark LP, Ungar J, Lipsitz S, Sequist TD. Trends in primary care clinician perceptions of a new electronic health record. J Gen Intern Med. 2009 Apr;24(4):464-8.

2. El-Kareh R, Gandhi TK, Poon EG, Newmark LP, Ungar J, Orav EJ, Sequist TD. Actionable Reminders Did Not Improve Performance over Passive Reminders for Overdue Tests in the Primary Care Setting. J Am Med Inform Assoc. 2011 Mar-Apr;18(2):160-3.

3. El-Kareh R, Roy C, Brodsky G, Perencevich M, Poon EG. Incidence and Predictors of Microbiology Results Returning Post-Discharge and Requiring Follow-up. J Hosp Med. 2011 May;6(5):291-6.

4. Kim H, El-Kareh R, Goel A, Vineet F, Chapman WW. An approach to improve LOINC mapping through augmentation of local test names. (2011) J Biomed Inform. Dec 21. PMID:22210167

5. El-Kareh R, Roy C, Williams DH, Poon EG. Impact of Automated Alerts on Follow-Up of Post-Discharge Microbiology Results: A Cluster Randomized Controlled Trial. (2012) J Gen Intern Med. Jan 26. PMID: 22278302

6. Jiang X, Boxwala AA, El-Kareh R, Kim J, Ohno-Machado L. A patient-driven adaptive prediction technique to improve personalized risk estimation for clinical decision support. (2012) J Am Med Inform Assoc. 19(e1):e137-e144. Jun 1; PMID: 22493049

7. Khanna R, Kim S, Jenkins I, El-Kareh R, Afsarmanesh N, Amin A, Sand H, Auerbach A, Chia C, Maynard G, Romano P, White R. Predictive Value of the Present-On-Admission Indicator for Hospital-acquired Venous Thromboembolism. (2013) Med Care. Apr 1. [Epub ahead of print] PMID: 23552437

8. El-Kareh R, Hasan O, Schiff GD. Use of health information technology to reduce diagnostic errors. BMJ Qual Saf. 2013 Oct;22 Suppl 2:ii40-ii51. doi: 10.1136/bmjqs-2013-001884. Epub 2013 Jul 13. PMID: 23852973

9. Shenvi E, El-Kareh R. Clinical criteria to screen for inpatient diagnostic errors: a scoping review. Diagnosis. 2015;2:3–19. doi: 10.1515/dx-2014-0047. PMID: 26097801

10. El-Kareh R, Pazo V, Wright A, Schiff GD. Losing weights: failure to recognise and act on weight loss documented in an electronic health record. J Innov Health Inform. 2015;22(3):316-322. PMID: 26577421

11. Hudspeth J, El-Kareh R, Schiff GD. Use of an Expedited Review Tool to Screen for Prior Diagnostic Error in Emergency Department Patients. Appl Clin Inform. 2015;6:619-28. PMID: 26767059

12. Singh A, Rhee K, Brennan J, Kuelbs C, El-Kareh R, Fisher E. Who’s My Doctor? Using an electronic tool to improve team member identification on an inpatient pediatrics team. Hosp Pediatr. 2016;6(3):157-65. PMID: 26920366

13. Awdishu L, Coates CR, Lyddane A, Tran K, Daniels CE, Lee J, El-Kareh R. The Impact of Real-Time Alerting on Appropriate Prescribing in Kidney Disease: a Cluster Randomized Controlled Trial. J Am Med Inform Assoc. 2016 May;23(3):609-16. PMID: 26615182

14. Bruce B, El-Kareh R, Ely J, Kanter M, Rao G, Schiff GD, Ten Berg MJ, McDonald KM. Methodologies for Evaluating Strategies to Reduce Diagnostic Error: Report from the Research Summit at the 7th International Diagnostic Error in Medicine Conference. Diagnosis. 2016; 3(1), pp. 1-7.

15. Sitapati A, Kim HK, Berkovich B, Marmor R, Singh S, El-Kareh R, Clay B, Ohno-Machado L. Integrated Precision Medicine: The Role of Electronic Health Records in Delivering Personalized Treatment. Wiley Interdiscip Rev Syst Biol Med. 2017 May;9(3). PMID: 28207198

16. Calvitti A, Hochheiser H, Ashfaq S, Bell K, Chen Y, El-Kareh R, Gabuzda MT, Liu L, Mortensen S, Pandey B, Rick S, Street RL Jr, Weibel N, Weir C, Agha Z. Physician activity during outpatient visits and subjective workload. J Biomed Inform. 2017 May;69:135-149. PMID: 28323114

17. Kim Y, El-Kareh R, Sun J, Yu H, Jiang X. Discriminative and Distinct Phenotyping by Constrained Tensor Factorization. Sci Rep. 2017 Apr 25;7(1):1114. PMID: 28442772

18. Schaefer G, El-Kareh R, Quartarolo J, Seymann G. Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population. Am J Med. 2017 May 22. pii: S0002-9343(17)30507-7. PMID: 28545885

19. Hwang DY, El-Kareh R, Davidson JE. Implementing Intensive Care Unit Family-Centered Care: Resources to Identify and Address Gaps. AACN Adv Crit Care. 2017 Summer;28(2):148-154. PMID: 28592474

20. Rhee KE, Kessl S, Lindback S, Littman M, El-Kareh RE. Provider views on childhood obesity management in primary care settings: a mixed methods analysis. BMC Health Serv Res. 2018 Jan 30;18(1):55. PMID: 29378579 10

21. Seymann G, El-Kareh R, Schaefer G, Quartarolo J. The Reply. Am J Med. 2018 Feb;131(2):e77. PMID: 29362112

22. Van de Velde S, Kunnamo I, Roshanov P, Kortteisto T, Aertgeerts B, Vandvik PO, Flottorp S, GUIDES expert panel. The GUIDES checklist: development of a tool to improve the successful use of guideline-based computerised clinical decision support. Implement Sci. 2018 Jun 25;13(1):86. PMID: 29941007

23. Shenvi EC, Feupe SF, Yang H, El-Kareh R. "Closing the loop": a mixed-methods study about resident learning from outcome feedback after patient handoffs. Diagnosis (Berl). 2018 Nov 27;5(4):235-242. PMID: 30240357

Other peer-reviewed publications

1. Jiang X, El-Kareh R, Ohno-Machado L. Improving predictions in imbalanced data using pairwise expanded logistic regression. (2011) AMIA Annu Symp Proc. 2011:625-34. Epub 2011 Oct 22. PMID:22195118

2. Wang S, Jiang X, Ji Z, El-Kareh R, Choi J, Kim H. When you can't tell when it hurts: a preliminary algorithm to assess pain in patients who can't communicate. AMIA Annu Symp Proc. 2013 Nov 16;2013:1429-37. PMID: 24551418

Non-peer reviewed scientific or medical publications/materials in print or other media

Proceedings of meetings or other non-peer reviewed research publications 1. Pham D, Alexander M, Arizpe A, Burgess B, Dietz C, Eisen L, El-Kareh R, Eno J, Gary S, Gerosa G, Goins B, Golab J, Golla R, Harris R, Ho B, Ho YW, Hoover K, Hunter C, Ippolito P, Jessani R, Kahle J, Kishore KR, Kuttanna B, Litch S, Mallick S, Ngo T, Ogden D, Olson C, Park SH, Patel R, Pham M, Prado J, Reeve S, Reininger R, Sanchez H, Schiffli M, Slaton J, Thuraisingham G, Torku K, Tran C, Vanderschaaf N, Voldstad P. A 3.0 W 75SPECint92 85SPECfp92 superscalar RISC microprocessor. In: Wuorinen J, editor. IEEE Int. Solid-State Circuits Conference. Digest of Technical Papers; 1994 Feb 16-18; San Francisco, CA. p. 212- 3. Commentaries and Editorials 1. El-Kareh R. Making Clinical Diagnoses: How Measureable Is the Process? In: National Quality Measures Clearinghouse (NQMC) [Web site]. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); [cited 2014 Oct 27]. Available: http://www.qualitymeasures.ahrq.gov.

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

1. El-Kareh R, Roy C, Williams D, Poon E. Impact of an Automated Electronic Alerting System

on Follow-Up of Post-Discharge Microbiology Results: A Cluster Randomized Controlled Trial. Presented at the 34th annual meeting of the Society of General Internal Medicine; 2011; Phoenix, AZ.

2. Lindstedt S, El-Kareh R. "Burned" By A Chemical Exposure: A Delayed Diagnosis. Presented at the Diagnostic Error in Medicine 4th International Conference; 2011; Chicago, IL.

3. Hudspeth J, El-Kareh R, Schiff G. Use of an Expedited Review Tool to Screen for Diagnostic Error in Patients Presenting to an Emergency Department. Presented at the Diagnostic Error in Medicine 4th International Conference; 2011; Chicago, IL.

4. El-Kareh R, Pazo V, Wright A, Schiff G. Frequent Failure to Recognize Weight Loss and Diagnose Its Cause in the Ambulatory Setting. Presented at the Diagnostic Error in Medicine 4th International Conference; 2011; Chicago, IL.

5. Awdishu L, Tran K, Coates C, Lyddane A, El-Kareh R. The Impact of Real-Time Dosage Guidance for CKD: A Cluster Randomized Controlled Trial. Presented at the American Society of Nephrology Kidney Week; 2012; San Diego, CA.

6. Shenvi E, El-Kareh, R. A Needs Assessment of Critical Care Physicians: Data Presentation for Anemia as a Prototypical Clinical Problem. Presented at the AMIA Annual Symposium; 2012; Chicago, IL.

7. FitzHenry F, Resnic FS, Basu A, Robbins,S, Nunes K, El-Kareh R, Kuo GM, Matheny M. Data Harmonization Barriers for Post Marketing Surveillance of Medications. Presented at the AMIA Annual Symposium; 2012; Chicago, IL.

8. Robbins SL, FitzHenry F, Matheny ME, Nookala LS, Basu A, Ohno-Machado L, Kuo GM, El-Kareh R, Paul P, Day ME, Resnic FS. Development of a Multi-Center Data Sharing Network for Safety Surveillance. Presented at the NCBC Showcase; NIH campus; 2012; Bethesda, MD.

9. Ross MK, El-Kareh R, Mowery D. Developing a Framework for Detecting Asthma Endotypes from Electronic Health Records. Presented at the American Thoracic Society Annual Meeting; 2014; San Diego, CA.

10. Feudjio Feupe S, El-Kareh R. Feedback of Patient Outcomes for Physicians-in-Training: Are those who need it most getting it the least? Presented at the Diagnostic Error in Medicine 7th International Conference; 2014; Atlanta, GA.

11. Shenvi E, El-Kareh R. Detectable Outcomes of Inpatient Diagnostic Error: A Conceptual Framework and Scoping Review. Presented at the Diagnostic Error in Medicine 7th International Conference; 2014; Atlanta, GA.

12. Shenvi E, El-Kareh R. Internal Medicine and Emergency Medicine Residents’ Perceptions of Outcome Feedback After Handoffs. Presented at the Diagnostic Error in Medicine 7th International Conference; 2014; Atlanta, GA.

13. Abeles SR, Myers F, El-Kareh R, Marmor R, Kovryga KM, Gohil SK, Cohen SH, Mahr N, Nichols A, Garritson S, Liu C, Rubin Z, Trout A, Allyn PR, Torriani FJ. No Significant Correlation between OR Traffic and Surgical Site Infections in a Multicenter Study. Presented at the Society for Healthcare Epidemiology of America Conference; 2016; San Diego, CA.

14. DeMonte R, Mullinax S, Kim Y, Jiang X, El-Kareh R. Quantifying the Cascade Effect of Testing. Presented at the Diagnostic Error in Medicine 9th International Conference; 2016; Los Angeles, CA.

15. Luo CC, Sasaki R, El-Kareh R, Sebasky M, Seymann G. Why do we stop washing our hands? Predictors of hand hygiene attitude and practice in medical school. Presented at the Society of Hospital Medicine Annual Conference; 2017; Las Vegas, NV.

16. Varughese J, Clay BJ, El-Kareh R. How Sweet It Is...Reducing Duplicate Hemoglobin A1c. Presented at the Society of Hospital Medicine Annual Conference; 2017; Las Vegas, NV.

17. Blansit K, Torriani FJ, Taplitz R, El-Kareh R. Does Improving Diagnostic Efficiency Have Financial Impact on Hospitals? A Cost Benefit Analysis of Clinical Decision Support Implementation. Presented at the Diagnostic Error in Medicine 10th International Conference; 2017; Newton, MA.

18. El-Kareh R, Huynh T, Chang J, Schnipper JL, Nguyen A, Medders K, Yam N, Hartman S, Shipman C, Biondo A, Chu ES. Development and Implementation of an Electronic Health Record based Medication Reconciliation Risk Stratification Tool to Optimally Deploy Limited Pharmacy Resources. Presented at Hospital Medicine 2018; Orlando, FL.

19. BK Mathews, R El-Kareh. Structured Case Reviews for Organizational Learning about Diagnostic Vulnerabilities: Initial Experiences from Two Medical Centers. Presented at the Diagnostic Error in Medicine 11th International Conference; 2018; New Orleans, LA.

20. PA Bergl, A Taneja, R El-Kareh, H Singh, RS Nanchal. Frequency of Diagnostic Errors and Associated Risk Factors in the MICU. Presented at the Diagnostic Error in Medicine 11th International Conference; 2018; New Orleans, LA.

Narrative Report

I am currently an Associate Professor in Medicine at the University of California, San Diego (UCSD), with effort in Biomedical Informatics, Hospital Medicine and Information Services. Roughly 70% of my effort involves evaluation and prioritization of clinical decision support technology, implementation of quality improvement projects within the hospital and direct patient care as a hospitalist at UC San Diego Health. The remaining 30% of my effort centers on the application of information technology to address preventable errors and delays in the diagnosis of medical conditions.

OMB No. 0925-0001 and 0925-0002 (Rev. 10/15 Approved Through 10/31/2018)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) DEGREE Completion (if Date FIELD OF STUDY INSTITUTION AND LOCATION applicable) MM/YYYY

Harvard College, Cambridge, MA A.B. 1981 Bioengineering Columbia University, New York, NY Ph.D. 1988 Biochem. Mol. Biophys. Columbia University, New York, NY M.D. 1989 Medicine Stanford U. Hospital, Palo Alto, CA Residency 1991 Int. Med Clin. Invstgtr Baylor College of Medicine, Houston, TX Residency 1992 Int. Med Clin. Invstgtr U. of Houston, Houston, TX Postdoc 1994 Chemistry

A. Personal Statement I am well suited to contribute to this project, based on my combined clinical and basic science training, and my long experience in research-related informatics and high-performance computing.

B. Positions and Honors Positions and Employment 1994-2000 Research Chemist, National Inst. Standards Technology and Adjunct Asst. Prof., Center for Advanced Research in Biotechnology, U. Maryland Biotechnology Institute, Rockville, MD 2000-2001 Associate Professor, Center for Advanced Research in Biotechnology, U. Maryland Biotechnology Institute, Rockville, MD 2001-2009 Professor, Center for Advanced Research in Biotechnology, U. Maryland Biotechnology Institute, Rockville, MD. 2010- Professor and Chair in Computer-Aided Drug Discovery, Skaggs School of Pharmacy and Pharmaceutical Sciences, U. California San Diego, La Jolla, CA.

Other Experience and Professional Memberships 1991- Licensed to practice medicine in at least one State. 2007-2009 Chair, NIH Macromolecular Structure and Function Study Section (MSFD) 2010- Co-Director, UCSD Drug Discovery Institute/Center for Drug Discovery Innovation

Honors 1981 Tau Beta Pi Engineering Award, Harvard College 1981 A.B. Magna cum Laude, Harvard College 1989 The Louis Gibofsky Memorial Prize for research, Columbia University College of Physicians and Surgeons 1991-1994 Howard Hughes Medical Institute Physician Research Fellowship

2014 Distinguished Lecture in Computational and Mathematical Biology, University of California, Irvine 2016 Peter A. Kollman Lectureship, University of California, San Francisco 2017 Keynote Lecture, 11th Asian International Medicinal Chemistry Symposia (AIMECS2017) Conference, on behalf of J. Med. Chem. and ACS Med. Chem. Lett., Melbourne, Australia, July 2017

C. Contribution to Science Link to ~120 of my ~150 publications: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40659788

1. My earliest contributions center on the theory and calculation of electrostatic interactions, which play fundamental roles in various aspects of biophysics. I was intimately involved in work leading to the application of classical electrostatics at the molecular level, including the dielectric theory of proteins, defining physically meaningful dielectric descriptions of proteins in the aqueous environment, use of finite-different methods to solve the Poisson-Boltzmann equation, demonstration that such methods could be used as part of a solvation free energy model and to compute forces for use in simulations, and to compute pKa shifts, and early work toward generalized Born-type models. Many of these ideas and methods continue to be in wide use to elucidate molecular mechanisms and as components of tools for computer-aided drug design, and we have made related contributions to electrostatic optimization of ligands and the role of electrostriction in aqueous solvation. My contributions here focused on development of core theories and methods that made the work possible, as well as design and execution of the studies. a. Gilson,M.K. and Honig,B. The dielectric constant of a folded protein. Biopolymers 25:2907- 2119, 1986. b. Gilson,M.K. and Honig,B. Calculation of the total electrostatic energy of a macromolecular system: Solvation energies, binding energies, and conformational analysis. Proteins: Structure, Function, and Genetics 4:7-18, 1988. c. Gilson,M.K. and Honig,B. The inclusion of electrostatic hydration energies in molecular mechanics calculations. J. Computer-Aided Drug Design 5:5-20, 1991. d. Gilson,M.K. Multiple-site titration and molecular modeling: Two rapid methods for computing energies and forces for ionizable groups in proteins. Proteins: Structure, Function and Genetics 15:266-282, 1993.

2. A second set of contributions concerns the formulation of models of binding, through connections with the fundamental statistical thermodynamics of molecular recognition. We elucidated and connected strands in the literature regarding issues such as changes in rotational and translational entropy of binding and the so-called “cratic entropy”; methods of computing absolute binding free energies and the role of the standard concentration; and various statistical thermodynamic expressions for the binding constant; along with related issues of how to handle symmetry in such calculations, and the dependence of configurational entropy with changes in coordinates. My contributions again centered on elucidation of core theoretical issues and their connection with practical applications in methodology and interpretation of data. a. Gilson,M.K., Given,J.A., Bush,B., and McCammon,J.A. The statistical-thermodynamic basis for computation of binding affinities. A critical review. Biophys. J. 72:1047-1069, 1997. PMC1184492. b. Mihailescu,M. and Gilson,M.K. On the theory of noncovalent association, Biophys.J., 87:23-36, 2004. PMC1304346. c. Zhou,H.-X. and Gilson,M.K. Theory of free energy and entropy in noncovalent binding, Chem. Rev., 109:4092-4107, 2009. PMC3329805. d. Fenley,A.T., Muddana,H.S. and Gilson,M.K. Entropy-enthalpy transduction due to conformational shifts can obscure the forces driving protein-ligand binding. Proc. Nat. Acad. Sci. USA, 109:20006-20011, 2012. PMC3523842

3. My lab addressed a central problem of data access for drug discovery, computer-aided drug design (CADD), chemical biology, and systems pharmacology, by creating, and continuing to operate, the first

publicly accessible database of measured protein-ligand binding affinities BindingDB. Ready access to such data is important for a variety of applications, including validation of CADD and QSAR methods, general medicinal chemistry, and prediction of drug mechanisms and side-effects. BindingDB went into operation in 2000 and now contains over a million data for over 450,000 small molecules and about 7,000 proteins. The web-site gets about 8,500 hits per month from users worldwide, and many more users download our datasets for offline use. In addition to basic query and browsing capabilities, BindingDB offers specialized tools, such as ones which allow users to obtain the data associated with articles of interest in electronic form; provide predictions of off-target effects of compounds; and link compounds to biomolecular pathways. The Protein DataBank (PDB) and PubChem provide links to BindingDB, and vice versa. My contribution were the original idea to create a public molecular recognition database, designing the original database and interface, overseeing development and maintenance, and ongoing design of new features and interfaces. a. BindingDB website: http://www.bindingdb.org b. Chen,X., Lin,Y., Liu,M. and Gilson,M.K. The Binding Database: data management and interface design. Bioinformatics 18:130-139,2002. c. Liu,T., Lin,Y., Wen,X., Jorissen,R.N. and Gilson,M.K. BindingDB: a web-accessible database of experimentally determined protein–ligand binding affinities. Nucl. Acids. Res. Database issue 35: D198-D201, 2007. PMC1751547. d. Gilson,M.K*., Liu,T., Baitaluk,M., Nicola,G., Hwang,L., and Chong,J., BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology. Nucleic Acids Res. Database Issue, doi: 10.1093/nar/gkv1072, 2015. PMC4702793

4. My lab has spearheaded the use of host-guest systems -- miniature models of molecular recognition - as sources of physical insight and test beds to rigorously test computational models. A key step was our introduction of the cucurbiturils to the computational community. These are of particular interest, as their affinities are often comparable to those of the tightest-binding protein-ligand systems. We also worked with computational and experimental labs to bring new host-guest test sets to the SAMPL blind prediction challenges, which have attracted participation from multiple labs developing software for affinity predictions. My contributions centered on identifying the value of host-guest systems and designing and overseeing studies which take advantage of their favorable properties. More recently, we have begun doing synthesis and experimental characterization of new host-guest systems, in order to expand the dataset available to test and improve computational methods. a. Chang,C. and Gilson,M.K. Free energy, entropy, and induced fit in host-guest recognition. J.Am.Chem.Soc. 126:13156-13164, 2004. b. Muddana,H.S., Varnado,D., Bielawski,C.W., Urbach,A.R., Isaacs,L., Geballe,M.T., and Gilson,M.K. Blind prediction of host-guest binding affinities: A new SAMPL3 challenge. J. Comput. Aided Mol. Des., 26:475-487, 2012. PMC3383923. c. Gao, K., Yin,J., Henriksen,N.M., Fenley,A.T. and Gilson,M.K. Binding enthalpy calculations for a neutral host–guest pair yield widely divergent salt effects across water models. J. Chem. Theory Comput. 10.1021/acs.jctc.5b00676, 2015. PMC4668924 d. Evaluation and minimization of uncertainty in ITC binding measurements: heat error, concentration error, saturation, and stoichiometry. Biochim. Biophys. Acta 1861:485-498, 2017. PMC5195854.

5. We have developed a number of methods, some widely used, for computing and interpreting the thermodynamics of noncovalent binding. These include the double-decoupling and attach-pull-release methods of computing standard (“absolute”) binding free energies; the mutual information expansion approach of extracting estimates of configurational entropy from simulations; the mining minima algorithm and software, now in use in the pharmaceutical industry; grid inhomogeneous solvation theory (GIST) approach to extracting information about water structure and thermodynamics from simulation data; and very recent work on computing binding enthalpies from dynamics simulations. We have also used these methods to gain insights into the determinants of measured binding thermodynamics. I contributed basic ideas underlying these methods, and developed GIST in collaboration with Prof. Thomas Kurtzman. a. Chen,W., Gilson,M.K., Webb,S.P. and Potter, M.J., Modeling protein-ligand binding by mining minima. J. Chem. Theo. Comput. 11:3540-3557, 2010. PMC3359898.

b. Killian,B.J., Kravitz,J.Y., and Gilson,M.K. Extraction of configurational entropy from molecular simulations via an expansion approximation. J. Chem. Phys., 127:024107, 2007. PMC2707031. c. Nguyen,C.N., Young,T.K., and Gilson,M.K. Grid inhomogeneous solvation theory: Hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril. J. Chem. Phys. 137:044101, 2012. PMC3416872. d. Henriksen, N.M., Fenley, A.T., and Gilson, M.K. Computational calorimetry: High-precision calculation of host-guest binding thermodynamics. J. Chem. Theory Comput. 10.1021/acs.jctc.5b00405, 2015. PMC4614838.

D. Current Research Support

R01 GM061300 Gilson (PI) 9/5/2014-8/31/18 NIH/NIGMS Theory and Modeling of Noncovalent Binding This project aims to develop insight into the determinants of noncovalent binding affinities and to create accurate computational methods to speed the discovery of new medications and targeted molecules for other biomedical applications. Configurational entropy, correlated motions, and molecular stress are key foci of research. Role: PI

R01 GM070064 Gilson (PI) 2/01/04-12/31/2020 NIH/NIGMS BindingDB: A Tool for Structure-Based Drug Discovery This project involves extracting a large volume of measured protein-ligand binding affinities from the scientific literature and making it searchable and downloadable via a web-accessible database with tools to support drug-discovery, molecular biology, and chemical biology. We are developing novel tools to search and and analyze these data on-line, including interconnections with biomolecular and signaling pathways. Role: PI. (Competitive renewal proposal is pending.)

U01GM111528 Gilson/Amaro, multi-PI 9/15/2014- 8/31/2019 NIH/NIGMS An Open Resource to Advance Computer-Aided Drug Design Computers are used to help design new drugs, and there is great promise for computational methods to become even more precise and effective than they are today. However, creating improved methods will require giving computational scientists access to many more experimental measurements of the properties of drugs and drug-like molecules than are now available, so that advanced methods can be tested and optimized. The present project will meet this need, and thus ultimately speed the discovery of new medications, by collecting the required data from research laboratories in the pharmaceutical industry and universities and organizing them in an electronic database so they can be easily accessed and used.

R01 GM100946 Gilson (Co-PI), Kurtzman (PI) 9/15/2018-5/31/2022 NIH/NIGMS Accounting for Water Structure and Thermodynamics in Computer-Aided Drug Design This project aims to develop new methods and computational tools that will speed structure-based drug- discovery by providing a detailed analysis of hydration structure and thermodynamics in targeted protein binding pockets, and incorporating this information into fast docking algorithms. Key aims are to extend the evaluation of grid-based inhomogeneous solvation theory (GIST) entropy terms up to second order, develop methods that allow GIST to be applicable to polarizable fields, and exploit empirical data on the patterning of hydrogen bonding sites surrounding bridging water molecules to develop a Pseudo Explicit Water (PEW) method that accounts for the thermodynamic consequences of water-mediated protein-ligand interactions.

MICHAEL ANDREW HOGARTH, MD, FACP, FACMI last updated Oct 2018

CURRICULUM VITAE

PERSONAL INFORMATION Email: [email protected] Academic Profile: http://profiles.ucsd.edu/michael.hogarth

CURRENT ACADEMIC APPOINTMENTS

Clinical Research Information Officer UC San Diego Health

Director, Biomedical Informatics Altman Clinical Translational Science Institute UC San Diego Health

Professor (02/2018 – ) Division of Biomedical Informatics Department of Internal Medicine UC San Diego School of Medicine

Professor (07/2009 – 06/2017) Department of Pathology and Laboratory Medicine UC Davis School of Medicine

Professor (Multi-location WOS-without salary) (02/2018 – 06/2020) Department of Pathology and Laboratory Medicine UC Davis School of Medicine

CLINICAL PRACTICE

UC Davis Health (09/1997 – 06/2018) General Internal Medicine Services attended: In-patient academic ward service, in-patient Internal Medicine consult service.

EDUCATION and TRAINING

05/1985 B.S. Bioengineering (Cum laude) College Station, TX Dept. of Industrial Engineering School of Engineering Texas A&M University

06/1991 Doctor of Medicine (M.D.) Dallas, TX Southwestern Medical School University of Texas

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07/1991-06/1992 Internal Medicine Internship Sacramento, CA Dept. of Internal Medicine UC Davis School of Medicine

07/1992-06/1993 Pathology - PGY2 Sacramento, CA Dept. of Pathology and Laboratory Medicine UC Davis School of Medicine

07/1994-03/1997 Internal Medicine PGY2-PGY3 Sacramento, CA Dept. of Internal Medicine UC Davis School of Medicine

07/1995-06/1997 Medical Informatics Fellowship Sacramento, CA Dept. of Pathology and Lab Medicine UC Davis School of Medicine

CERTIFICATIONS American Board of Internal Medicine, recertified, 2013-2023 (#168166) Fellow, American College of Medical Informatics (FACMI) Fellow, American College of Physicians (FACP) California Medical Board License: #A051060 (1992-present)

HONORS AND AWARDS Larry L. Sautter Honorable Mention, UC Office of the President 2018 Elected to American College of Medical Informatics, ACMI 2015 Larry L. Sautter Award (team award), UC Office of the President 2013 Nicholas E. Davies Award (team award), HIMSS 2013 Outstanding Service Award, UC Davis Extension, UC Davis 2012 caBIG Advancing Innovation Award, National Cancer Institute 2010 Certificate of Recognition, Health IT Planning, California HHS 2009 Certificate of Appreciation, California Coroner’s Association 2004 Certificate of Appreciation, UCD Clinical Lab Scientist Training Program 2004 Outstanding Teaching Award, Internal Med, UC Davis Sch. of Medicine 1992 Tau Beta Pi Engineering National Honor Society 1985 Cum laude (Texas A&M University) 1985

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CURRENT RESEARCH INTERESTS

• Public health informatics and information systems • Data quality in biomedical information systems and clinical data repositories. • Terminology/ontology systems in biomedicine • Clinical Natural Language Processing (cNLP)

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GRADUATE STUDENTS Swati Singh, Masters Degree, UCD Health Informatics 2018 Basel Quenam, Masters Degree, UCD Health Informatics 2017 Courtney Jang – Masters Degree, UCD Health Informatics 2017 Tara Sharifzadeh – Masters Degree, UCD Health Informatics 2017 Parry Pardun – Masters Degree, UCD Health Informatics 2017 Mona Alsaffar – Masters Degree, UCD Health Informatics 2016 Satjiv Kohli – Masters Degree, UCD Health Informatics 2015 Satish Mahajan – PhD Degree, UCD School of Nursing 2015 Jodi Nygaard - Masters Degree, UCD Health Informatics 2014 Gary Kean – Masters Degree, UCD Health Informatics 2014 Kristi Navarro – Masters Degree, UCD Health Informatics 2014 Tanuj Patel -- Masters Degree, UCD Health Informatics 2014 David Chin – PhD Degree, UCD Epidemiology 2013 Jesse Landis – Master Degree, UCD Public Health 2013 Ed Bean – Masters Degree, UCD Health Informatics 2013 Trevor Jukes – Masters Degree, UCD Health Informatics 2013 Stephanie Soares – Masters Degree, UCD Health Informatics 2013 Radhika Srinivasan – Masters Degree, UCD Health Infor 2011 Bill Riedl - Masters Degree, UCD Health Informatics. 2010 Paul Singh Pannu - Masters Degree, UCD Health Informatics 2009 Jay Zhou - Masters Degree, UCD Medical Informatics. 2000 Gillian Hubble - Masters Degree, UCD Medical Informatics. 1999

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FUNDING

CURRENT FUNDING:

2014-2018 Developing Capacity in Data Analytics Necessary to Work with Big Data Held in Health Care Systems (IA #13-90390-A01) (PI: Hogarth) California Department of Health Services (DHCS) $3,403,070

2014-2018 pSCANNER: Patient-oriented Scalable National Network for Effectiveness Research-Phase 2 (PI: Ohno-Machado; UCSD) Agency: PCORI (UCSD is the lead site) UCD site budget: $309,655

2015-2019 (IA #14-10588-A01) California Integrated Vital Records Registration System (CA-IVRS) (PI: Hogarth) Agency: California Department of Public Health (CDPH) $11,863,143

2015-2020 5UL1TR001442-03. UC San Diego Clinical Translational Research Institute (CTRI) (PI: Firestein) Agency: NCATS $8,383,455

2017-2020 AID-OAA-A-11-00012 Computational modeling of active tuberculosis using clinical, immunological, and radiological data (PI: Hogarth) Agency: National Academy of Sciences (NAS) $225,206

2018-2020 OPASS-19-18222-G. Enhancement of Maryland Vital Records Systems (PI: Hogarth) Agency: Maryland Department of Health (MDH) $805,056

2017-2023 “All of US” Precision Medicine Initiative (PI: Ohno-Machado) Agency: National Institutes of Health (NIH) $9,615,364

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COMPLETED FUNDING:

2014-2018 Maryland Electronic Death Registration System (MD-EDRS) (PI: Hogarth) Agency: Maryland Department of Public Health $222,552

2015-2017 I-SPY2: An Adaptive Breast Cancer Trial in the Setting of Neoadjuvant Chemotherapy (PI: Esserman; UCSF) Agency: Quantum Leap Collaborative/UCSF (A123916/9061-00SC) $295,450

2010-2015 California Electronic Death Registration System (CA-EDRS) (PI: Hogarth) Interagency Agreement #09-11648 Agency: California Department of Public Health (CDPH) $8,617,248

2011-2015 I-SPY2 Adaptive Breast Cancer Trial (PI: Esserman; UCSF) Agency: Foundation for the NIH (FNIH) -- (subaward) $558,688

2013-2014 INteroperability to Support Practice Improvement, disease REgistries and Care Coordination (PI: Hogarth) Agency: California Health eQuality (CHeQ) $741,960

2011-2013 TRANSCEND 2 - TRANslational Informatics System to Coordinate Emerging Biomarkers, Novel Agents, and Clinical Data (PI: Esserman; UCSF) SAIC-Frederick subcontract # 28XS197 Agency: National Cancer Institute (NCI) $1,500,000

2008-2010 TRANSCEND 1 - TRANslational Informatics System to Coordinate Emerging Biomarkers, Novel Agents, and Clinical Data (PI: Esserman; UCSF) SAIC-Frederick subcontract # 28XS197 Agency: National Cancer Institute (NCI) $1,100,000

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2004-2009 California Electronic Death Registration System (CA-EDRS) (PI: Hogarth) Interagency Agreement: 04-35764 (2004 – 2009) Agency: California Department of Public Health (CDPH) $7,000,000

2008-2009 A Biospecimen Repository Infrastructure for UC Davis (PI: Lars Berglund; UCD) Center Award, UC Davis Center for Clinical and Translational Science (CTSC) $50,000

2008-2009 California Electronic Death Registration System (CA-EDRS) (PI: Hogarth). IA #04-35764 $1,980,000

2003-2007 Blueprint for Regional Excellence in Breast Cancer #BC022339 (PI: Esserman; UCSF) Department of Defense (DoD) $6,700,000

2001-2004 Informatics Tools to Reduce Warfarin Errors (PI: Dr. Richard White) Agency for Healthcare Quality Research (AHRQ) $1,200,000

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PUBLICATIONS

2018 (1) Ohno-Machado L, Kim J, Gabriel RA, Kuo GM, Hogarth, MA. Genomics and electronic health record systems. Human Molecular Genetics. 18 April 2018. (2) Green R, Hogarth MA, Prystowsky MB, Rashidi HH. The job market outlook for residency graduates: Clear weather ahead for the butterflies? Arch Pathol Lab Med. 2018. Apr; 142(4):435-438.

2017 (3) Qenam B, Kim TY, Carroll MJ, Hogarth M. Text simplification using consumer health vocabulary to generate patient-centered radiology reporting: Translation and evaluation. J Med Internet Res. 2017 Dec 18;19(12):e417. (4) Jason Y Park, Toby Cornish, Michael Hogarth, Brian Jackson, and Kristen Rosati. Patient privacy and clinical laboratory data. Clin Chem. 2017. Aug; 63(8):1321-1325. (5) Esserman LJ, WISDOM Study and Athena Investigators. The WISDOM Study: Breaking the deadlock in the breast cancer screening debate. NPJ Breast Cancer. 2017 Sep 13;3:34. (6) Mona Alsaffar, Peter Yellowlees, Alberto Odor, Michael Hogarth. The state of open source electronic health record projects: A software anthropology study. Journal of Internet Research (JMIR). 2017. 5(1):e6:1-10.

2016

(7) John W. Park, Minetta C. Liu, Douglas Yee, Christina Yau, Laura J. van 't Veer, W. Fraser Symmans , Melissa Paoloni, Jane Perlmutter, Nola M. Hylton, Michael Hogarth, Angela DeMichel e, Meredith B. Buxton, A. Jo Chien, Anne M. Wallace,Judy C. Boughe, Tufia C. Haddad,Stephen Y. Chui/Kathleen A. Kemmer,Henry G. Kaplan, Minetta C. Liu/Claudine Isaacs, Rita Nanda, Debasish Tripathy, Kathy S. Albain, Kirsten K. Edmiston, Anthony D. Elias,Donald W. Northfelt,Lajos Pusztai/Stacy L. Moulder, Julie E. Lang/Rebecca K. Viscusi, David M. Euhus/Barbara B. Haley,Oamar J. Khan, William C. Wood, Michelle Melisko (UCSF), Richard Schwab (UCSD) , Julia Lyandres, Sarah E. Davis, Gillian L. Hirst, Ashish Sanil, Laura J. Esserman and Donald A. Berry,on behalf of the I- SPY2 Investigators. Neratinib plus neoadjuvant therapy for high-risk breast cancer: Efficacy results from the Phase 2 randomized I-SPY2 trial. N Engl J Med. 2016 Jul 7;375(1):11-22. (8) Hope S. Rugo, Olufunmilayo I. Olopade, Angela DeMichele, Christina Yau, Laura J. van ‘t Veer, Meredith B. Buxton, Michael Hogarth, Nola M. Hylton, Melissa Paoloni, Jane Perlmutter, W. Fraser Symmans, Douglas Yee, A. Jo Chien, Anne M. Wallace, Henry G. Kaplan, Judy C. Boughey/ Tufia C. Haddad, Kathy S. Albain, Minetta C. Liu/Claudine Isaacs, Qamar J. Khan, Julie E. Lang/Rebecca K. Viscusi, Lajos Pusztai/Stacy L. Moulder, Stephen Y. Chui/Kathleen A. Kemmer, Anthony D. Elias, Kirsten K. Edmiston, David M. Euhus/Barbara B. Haley, Rita Nanda, Donald W. Northfelt, Debasish Tripath, William C. Wood, Cheryl Ewing (UCSF), Richard Schwab (UCSD), Julia Lyandres, Sarah E. Davis, Gillian L. Hirst, Ashish Sanil, Donald A. Berry and Laura J. Esserman. Results from the I-SPY2 trial for high risk

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breast cancer: Efficacy of Valiparib/Carboplatin plus standard neoadjuvant therapy. N Engl J Med. 2016 Jul 7;375(1):23-34.

2015 (9) Robert Hiatt, Caroline Tai, Douglas Blayney, Dennis Deapen, Michael Hogarth, Kenneth Kizer, Joseph Lipscomb, Jennifer Malin, Stephen, Phillips, John Santa, Deborah Schrag. Leveraging state cancer registries to measure and improve the quality of cancer care: A potential strategy for California and beyond. Journal of the National Cancer Institute (JNCI). Pre-pub online – J Natl Cancer Inst. 2015 Mar 11;107(5). Pii:djv047; doi:10.1093/jnci/djv047 (10) Akshay Mani, Resmi Ravindran, Soujanya Mannepalli, Daniel Vang, Paul Luciw, Michael Hogarth, Imran Khan, V.V. Krishnan. Data mining strategies to improve multiplex microbead immunoassay tolerance in a mouse model of infectious diseases. PLoS One. 2015 Jan 23;10(1):e0116262. Doi:10.1371/journal.plone/0116262 (11) Jeremy Warner, Suzanne Maddux, Kevin Hughes, John Krauss, Peter Yu, Lawrence Shulman, Deborah Mayer, Mike Hogarth, Mark Shafarman, Allison Fiscallini, Laura Esserman, Liora Alschuler. Development, implementation, and initial evaluation of a foundational open interoperability standard for oncology treatment planning and summarization. J Am Med Inform Assoc (JAMIA). 2015 May;22(3):577-86

2014 (12) Lucila Ohno-Machado, Zia Agha, Doug Bell, Lisa Dahm, Michele E. Day, Jason N. Doctor, Davera Gabriel, Mini Kahlon, Katherine K. Kim, Michael Hogarth, Michael Matheny, Daniella Meeker, Jonathan Nebeker and the pScanner team. pScanner: Patient-centered SCAlable National Network for Effectiveness Research. J Am Med Inform Assoc (JAMIA). 2014. Jul-Aug:21(4):621-6.

2013 (13) Jeff Rowe, Karl Levitt, Mike Hogarth. Towards the realization of a public health model for shared secure cyber-space. Proceedings of the 2013 New Security Paradigms Proceedings. 2013. p11-18. (14) Elson SL, Hiatt RA, Anton-Culver H, Howell LP, Naeim A, Parker BA, Van’t Veer LJ, Hogarth M, Pierce JP, Duwors RJ, Hajopoulos K, Esserman LJ; The Athena Breast health Network: Developing a rapid learning system in breast cancer prevention, screening, treatment, and care. Breast Cancer Res. Treat. 2013 Jul; 140(2):417-25.

2012 (15) Yee D, Haddad T, Albain K, Barker A, Benz C, Boughey J, Buxton M, Jo Chien A,Demichele A, Dilts D, Elias A, Haluska P, Hogarth M, Hu A, Hytlon N, Kaplan HG,Kelloff GG, Khan Q, Lang J, Leyland-Jones B, Liu M, Nanda R, Northfelt D, OlopadeOI, Park J, Parker B, Parkinson D, Pearson-White S, Perlmutter J, Pusztai L,Symmans F, Rugo H, Tripathy D, Wallace A, Wholley D, Van't Veer L, Berry DA, Esserman L. Adaptive trials in the neoadjuvant setting: A model to safely tailor care while accelerating drug development. J Clin Oncol. 2012 Dec 20;30(36):4584-6. (16) Cohen E, Belkora J, Tyler J, Schreiner J, Deering MJ, Grama L, Duggan B, Illi J, Pederson J, Anand A, Teng A, McCreary E, Moore D, Tripathy D, Hogarth M,

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Lieberman M, Park J, Esserman L. Adoption, acceptability, and accuracy of an online clinical trial matching website for breast cancer. J Med Internet Res. 2012 Jul 11;14(4).

2010 (17) Hogarth M, Hajopoulos K, Young M, Cowles N, Churin J, Hornthal B, Esserman L. The Communication and care plan: A novel approach to patient-centered clinical information systems. J. Biomed Inform. 2010 Oct;43(5 Supple):S6-8. (18) Riedl A, Than N, Hogarth M. Using the UMLS and Simple Statistical Methods to Semantically Categorize Causes of Death on Death Certificates. Proc AMIA Symp. 2010. (19) Bishop M, Cummins J, Peisert S, Singh A, Bhume B, Agarwal D, Frincke D, Hogarth M. Relationships and data sanitation: A study in scarlet. New Security Paradigms Workshop Proc. 2010.

2008 (20) Yellowlees PM, Marks LS, Hogarth M, Turner S. Standards-based, open-source electronic health record systems: A desirable future for the U.S. health industry. Telemed J E Health, 14(3):284-8. 2008.

2007 (21) Yellowlees PM, Marks SL, Hogarth M, Turner S. Open-source electronic health record systems: A desirable future for the U.S. health industry. Telemedicine and e- Health. Jan 2007.

2006 (22) Yellowlees PM, Hogarth M, Hilty DM. The importance of distributed broadband networks to academic biomedical research and education programs. Acad Psychiatry. 30(6):451-5. 2006.

2005 (23) Hogarth MA, Turner S. A Study of Clinically Related Open Source Software Projects. Proc AMIA Symp. 330-334. 2005. (24) Kravitz RL, Neufeld JD, Hogarth MA, Paterniti DA, Dager W, White R. The Long Road from Insight to Implementation: Lessons from a Multi-site Trial of a PDA- Based Warfarin Dose Calculator Advances in Patient Safety: From Research to Implementation. Agency for Healthcare Research and Quality (AHRQ); Feb 2005; 395-409.

2004 (25) Cardiff RD, Rosner A, Hogarth MA, Galvez JJ, Borowsky AD, Gregg JP. Validation of the new challenge for pathology. Toxicologic Pathology, 32 Suppl 1:31-9. 2004.

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2003 (26) Elkin PL, Brown SH, Lincoln MJ, Hogarth M, Rector A. A Formal Representation for Messages Containining Compositional Expressions. International Journal of Medical Informatics (IJMI). 71(2-3):89-102. 2003. (pubmed id: 14519402) (27) Srinivas PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones EG, Gorin, FA. Semi- automated generation of neuroanatomical terms and acronyms with a comparison between two neuroanatomical terminologies. Neuroinformatics Journal, 1(2):177-192. 2003. (28) Howell LP, Hogarth M, Anders TF. Implementing a Mission-Based Reporting System at an Academic Health Center. Academic Medicine. 78(6):645-51. (pubmed id: 12805050). 2003.

2002 (29) Gertz M, Sattler KU, Gorin FA, Hogarth MA, Stone J: Annotating Scientific Images: A Concept-based Approach. Proceedings of the 14th International Conference on Scientific and Statistical Database Management. 2002. (30) Howell LP, Hogarth M, Anders TF. Creating a Mission-based Reporting System at an academic healthcenter. Acad Med. 77(2):130-8. (pubmed id: 11841972). 2002.

2001 (31) Gorin FA, Hogarth MA, Gertz M. The challenges and the rewards of integrating diverse neuroscience information. Neuroscientist. 7(1):18-27. (pubmed id: 11486341). 2001.

2000 (32) Zhou J, Hogarth MA, Walters RF, Green R, Nesbitt TS, Hybrid System for Telepathology. Human Pathology 31(7): 829-833, (pubmed id: 10923920). 2000. (33) Hogarth MA, Gertz M, Gorin FA. Terminology query language: a server interface for concept-oriented terminology systems. Proc AMIA Symp.349-53. (pubmed id: 11079903). 2000.

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CONFERENCE ABSTRACTS and POSTERS

(1) Integrating Electronic Death Registration with Electronic Health Records Systems: Results of a Trial Use of the VRDR Profile. Vira Danak, Glenna Gobar, Michelle Williamson, Michael Hogarth. AMIA Fall Symposium. 2016 (2) Abstract CT106: Efficacy of pertuzumab/trastuzumab/paclitaxel over standard trastuzumab/paclitaxel therapy for HER2+ breast cancer: Results from the neoadjuvant I-SPY 2 TRIAL. Meredith Buxton, Angela M. DeMichele, Stephen Chia, Laura van't Veer, Jo Chien, Anne Wallace, Henry Kaplan, Julie Lang, Douglas Yee, Claudine Isaacs, Stacy Moulder, Kathy Albain, Judy Boughey, Kathleen Kemmer, Barbara Haley, Susan Minton, Andres Forero, Rita Nanda, Anthony Elias, Larissa Korde, Rebecca Viscuzi, Hope Rugo, Richard Schwab, Fraser Symmans, Melissa Paoloni, Nola Hylton, Michael Hogarth, Julia Lyandres, Jane Perlmutter, Ashish Sanil, Christina Yau, Laura Esserman, Don Berry and I-SPY 2 TRIAL Investigators. Cancer Res July 15 2016 (76) (14 Supplement) CT106; DOI: 10.1158/1538-7445.AM2016-CT106 (3) Abstract CT042: Efficacy of T-DM1+pertuzumab over standard therapy for HER2+ breast cancer: Results from the neoadjuvant I-SPY 2 TRIAL. Angela M. DeMichele, Stacy Moulder, Meredith Buxton, Douglas Yee, Anne Wallace, Jo Chien, Claudine Isaacs, Kathy Albain, Judy Boughey, Kathleen Kemmer, Barbara Haley, Julie Lang, Henry Kaplan, Susan Minton, Andres Forero, Anthony Elias, Rita Nanda, Larissa Korde, Richard Schwab, Michelle Melisko, Ashish Sanil, Michael Hogarth, Nola Hylton, Melissa Paoloni, Fraser Symmans, Jane Perlmutter, Julia Lyandres, Christina Yau, Don Berry, Laura Esserman and I-SPY 2 TRIAL Investigators. Cancer Res July 15 2016 (76) (14 Supplement) CT042; DOI: 10.1158/1538-7445.AM2016-CT042. (4) Abstract P3-06-37: I-SPY 2 qualifying biomarker evaluation (QBE): The challenge and opportunity for interrogating predicted pathways in an adaptive design biomarker rich trial. Christina Yau, Denise Wolf, Ashish Sanil, Laura van 't Veer, Emanuel F Petricoin, Meredith Buxton, Joe Gray, Angela DeMichele, Mike Hogarth, Nola Hylton, Jane Perlmutter, Melissa Paoloni, Fraser Symmans, Doug Yee, Don Berry and Laura Esserman. Cancer Res May 1 2015 (75) (9 Supplement) P3-06-37; DOI: 10.1158/1538-7445.SABCS14-P3-06-37. (5) Davera Gabriel, Nick Anderson, Mike Hogarth. The semantic alignment lifecycle: A best practice developed to harmonize distributed research resources. Proc AMIA Symp. Oct. 2013. P469-470. (6) Abstract P4-13-13: Risk Assessment and Personalized Decision Support: The University of California Athena Breast Health Network. EM Ozanne, B Crawford, A Petruse, L Madlensky, L Weiss, M Hogarth, N Wenger, D Goodman, H Park, H Anton-Culver, S Yasmeen, L Howell, H Ojeda, BA Parker, C Kaplan, Veer L van't, L Esserman and A Naeim. Cancer Res December 15 2012 (72) (24 Supplement) P4-13- 13; DOI: 10.1158/0008-5472.SABCS12-P4-13-13 (7) Radhika Srinivasan, Albert Riedl, Estella Geraghty, Michael Hogarth. Evaluation of a natural language processing platform in concept tagging of surgical pathology reports for information retrieval. AP III, Pittsburgh PA. 2011. Also in J Pathol Inform 2011 – Abstracts Supplement, pS21-22.

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(8) Riedl A, Geraghty E, Anderson K, Hogarth M. Automated classification of death events: Using natural language processing in public health. Proc AMIA Symp. Oct 211. (9) Hogarth M, Bechtold T, Esserman L. An XML-based specification for electronic patient reported data exchange. Proc AMIA Symp. 2010. (10) Hogarth MA, Esserman L. Development of an Integrated Platform for Breast Cancer Care Era of Hope Annual Symposium, Dept. of Defense, Baltimore, MD. 2008. (11) Esserman LJ, Hogarth M, Melisko M, Hwang S, Ewing C, Cohen E, Belkora J, Ozanne E, Rugo H, Rayamajhi S, Mahoney E, Kamerick M, Mendelsohn M, Park J. Blueprint for Regional Excellence in Breast Cancer (view paper). Era of Hope Annual Symposium, Dept. of Defense, Baltimore, MD. 2008. (12) Esserman LJ, Mendelsohn M, Cohen E, Spillman A, Pederson J, Melisko M, Ananc A, Laird J, Ernest ML, Hamlosky D, Park J, Hogarth M, Bechtold T, Weiss LT. Using Patient Self-reported Data to Increase Access and Improve Quality of Care. Era of Hope Annual Symposium, Dept. of Defense, Baltimore, MD. 2008. (13) Cohen EJ, Bechtold T, Laird J, Anand A, Ernest ML, Pederson, Melisko M, Park J, Hogarth MA, Esserman L. BreastCancerTrials.org: From Regional Pilot to Nationwide Clinical Trial Matching Service. 30th Annual San Antonio Annual Breast Cancer Symposium. San Antonio, TX. 2007 (14) Cohen EJ, Schreiner J, Tyler J, Deering MJ, Grama LM, Duggan B, Laird JL, Bhatia V, Hogarth M, Lieberman M, Esserman LJ, Park JW. BreastCancerTrials.org: Feasibility of an online, patient-centered clinical trial matching service. 30th Annual San Antonio Annual Breast Cancer Symposium. San Antonio, TX. 2007 (15) Hogarth MA, Sanket Bansal, Abhijhat Upadhyay, Kevin Kunkel, Glenna Gobar. A Novel Voice Signature Method for Electronic Death Registration Systems. Proc AMIA Symp. 981. 2005. (16) J.Schreiner, J. Tyler, E.Cohen, M.Hogarth, L.Esserman. S.Subman, M.Deering, L.Grama, H.Massett, B.Duggan, JJ Jaurer, C.Griffin, S.Patel. caMATCH: A Pilot Research Project in Patient Entered PHRs for Clinical Trial Matching Services. NIH Research Festival. 2005. (17) Michael Kamerick, Michael Dore, Anna Simonenko, Michael Hogarth, Jeff Belkora, Laura Esserman. “A General Platform for the Delivery of Point of Care Applications, Clinical Decision Aids, and Patient Interactions: Informatics Systems of the Center of Excellence at UCSF “ - NCI . 2005. (18) Hogarth MA, Gertz M, Gorin FA. jTerm: An Open Source Terminology Server. AMIA Fall Symposium. 2003. (19) Srinivas, PR, Gusfield D, Mason O, Gertz M, Hogarth M, Stone J, Jones E, Gorin F. Extraction and Comparison of Neuroanatomical Concepts using a ‘Hybrid’ Statistical Parser coupled to a Concept-based Vector Space Model, Human Brain Project conference, NIH/NIHM, Washington DC. 2003. (20) Hogarth MA, Gertz M, Gorin, FA. Linking Images to Knowledge through Concept- based Mediation, COAST Conference, Asilomar, CA. 2002. (21) Hogarth MA, Stone J, Gorin, FA. jTerm: A Server for Terminological Systems, AMIA Fall Symposium, Washington DC. 2001.

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(22) J. Zhou, MD, M.A. Hogarth, MD, R.F. Walters, PhD, R. Green, MD, and T.S. Nesbitt, MD. Telepathology Using Dual Camera Hybrid System. Proc AMIA Symp. 2000.

BOOKS

(1) Hogarth M, Hutchinson D. An Internet Guide for the Health Professional, 2nd edition (New Wind Publishing, Sacramento, CA) ISBN 0 965 14120 9. 1996

(2) Hutchinson D, Hogarth, M. A Pocket Guide to the Medical Internet. (New Wind Publishing, Sacramento, CA) 1996

(3) Hogarth M. An Internet Guide for the Health Professional, 1st ed. 1995. http://informatics.ucdavis.edu/mikehogarth/pubs/MedGuide.pdf

BOOK CHAPTERS

(1) Jason Hunter. Java Servlet Programming, 2nd Edition O’Reilly Publishing. 2010. Technical reviewer.

(2) Jose J. Galvez, Robert J. Munn, Andrew S. Garbutt, Michael A Hogarth, Betty I. Tarnowski, and Robert D. Cardiff. Development of a Whole Slide Image Archive. In Virtual Slides in Teaching, Diagnosis, and Research. Advances in Pathology, Microscopy, and Molecular Morphology. Eds. Gu and Hacker. Taylor and Francis. pp325-335. 2005.

(3) Nesbitt T, Hilty DM, Hogarth MA, Yellowlees P. Rural Health Care in the Digital Age: The Role of Information and Telecommunication Technologies in the Future of Rural Health. Quality Through Collaboration: The Future of Rural Healthcare. Institute of Medicine (IOM) Report. 2005.

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PRESENTATIONS

2019 Informatics in disease management: What will the future bring?. Special Keynote, Advances in Critical Care Nephrology (AKI&CRRT). UC San Diego. San Diego. Feb 27, 2018

Enhancing surveillance with “something olde and something new”. Keynote. International Society of Disease Surveillance (ISDS). San Diego. Feb 1, 2019

2018 The clinical research information officer and electronic infrastructure to support clinical research. Seminar, UC Davis Div of General Medicine. UC San Diego. San Diego. Aug 1, 2018

Informatics and the merging of research and quality measures with bedside care. Grand Rounds, Rady Children’s Hospital. UC San Diego. San Diego. Aug 14, 2018

The clinical research information officer and electronic infrastructure to support clinical research. Seminar, UC Davis Div of General Medicine. UC San Diego. San Diego. Aug 1, 2018

Keeping us safe: An Overview of US public health informatics systems and architectures. DBMI Seminar. UC San Diego. San Diego. Feb 17, 2018

2017 From bits to qubits: Can medicine benefit from quantum computing? MHI290 Seminar. UC Davis Health. Sacramento. May 31, 2017

Querying clinical data to address public health needs. P21Conference: Advancing Prevention in the 21st Century. Invited by Calif. Dept. of Public Health. May 17, 2017

Data Quality Matters: EHR Data Quality, MACRA, and Improving Healthcare. HIT Summit General Session. San Jose. April 14, 2017.

From Meaningful Use to Meaningful Outcomes: Using Clinical Data to Support Care Improvement. HIT Summit Executive Roundtable. San Jose. April 13, 2017.

Linking Electronic Patient Records and Death Records: Challenges and Opportunities. UCSF. March 21, 2017.

OneSource: An Approach to Structured Sourcing of Key Clinical Data. UC San Diego Bioinformatics Seminar. Feb 17, 2017.

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2016 pSCANNER’s Value: Beckstrom’s Law at Work pSCANNER annual meeting. San Diego, CA. Oct. 13, 2016.

Distributed Clinical Data Networks: A Emerging Information Infrastructure. California Department of Public Health. Sept 27, 2016

MACRA, MIPS and Value-Based Healthcare: The Role of the Health Information Exchange. SHIEC Conference 2016. Scottsdale, AZ. Sep 9, 2016

Resolving Data Quality Issues in Health Information Exchange. SHIEC Conference 2016. Scottsdale, AZ. Sep 9, 2016

Leveraging a Common Data Model to Characterize The Quality of Data in a Clinical Data Warehouse. 10th Annual Redwood MedNet Conference. Santa Rosa, CA. Jul 18, 2016

The Good, the bad, and the Beautiful. Panelist. Enhancing The Application of Real World Evidence in Regulatory Decision-Making. Washington DC. March 3, 2016

Integrating Electronic Death Registration into Electronic Health Record Systems: A Pilot. NAPHSIS Information Technology Committee. Feb 2, 2016

2015 Current Challenges in the Implementation of Health Analytics 4th Annual Biomedical Informatics Symposium, Georgetown University Washington DC. Oct 16, 2015

Data From Life’s Unavoidable Events – California’s Birth and Death Registries iDASH-pSCANNER Data Sharing Symposium Oct 1, 2015

California Cancer Reporting Conference: 2015 and Beyond! Program Chair. Sacramento, CA. Sep 1 2015

Clinical Registries: Improving Healthcare with Population Data Sets K30 Program Lecture. UCDMC. Sacramento CA. Aug 18, 2015

A Trial Implementation of a “High Density” Health Information Exchange Standard: Are We Ready for “Coordinated” Care in High Impact Conditions? Redwood MedNet 9th Annual Symposium. Santa Rosa, CA. July 31, 2015

Classic Papers in Medical Informatics. Guest Lecturer. Division of Biomedical Informatics. UCSD. San Diego, CA. Mar 2015.

Building Health Informatics Infrastructure to Support Quality Improvement. Presenter. UCDHS Quality Improvement Special Interest Group. Sacramento, CA.

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Mar 2015

Classic Papers in Medical Informatics. Guest Lecturer. Department of Biomedical Informatics. Stanford University. Palo Alto, CA. Mar 2015.

2014 Public Health Information Systems and Interoperability – data standards in public health informatics. Guest Lecturer. UCSD Biomedical Informatics Graduate Program. San Diego, CA. Oct 2014.

Sensors, Wearables, and Interoperability. Expert Panel. Silicon Valley Health Forum. San Jose, CA. Sep 2014

Project INSPIRE: Lessons from the interoperability bleeding edge Redwood MedNet Conference. Santa Rosa, CA. July 2014

Pathology Informatics: Past, Present, and Future. UCD Pathology Grand Rounds. Sacramento, CA. July 2014

Project INSPIRE: Improving Data Capture and Exchange in Support of Cancer Care. ASCO Interoperability Summit. ASCO HQ, Alexandria, VA. June 2014

NLP and clinical records: Are we focused on the right thing? Cancer Informatics for Cancer Centers (CI4CC). Napa, CA. May 2014

Informatics in support of healthcare analytics: Enabling a learning healthcare system. UCD Health Informatics Seminar Series. Sacramento, CA. April 2014

Next Generation Registries: Capturing the Phenotype. Personalized Medicine Workshop. San Francisco, CA. April 2014

2013 Health Information Exchange and Quality of Care. California HIE Summit sponsored by California Dept. of Public Health. Sacramento. May 2013

Core Informatics Principles and Modern Institutional Bio-Banking: The Road Ahead. Biorepository Symposium & Robert E. Stowell Lectureship. UC Davis Health System. May 2013

The Affordable Care Act, ACO’s, Value-Based Purchasing: HIT Implications. Health Technology Forum – San Diego Chapter. CA. Mar 2013

From Registries to Population Health Management: The Informatics Implications of a Rapidly Evolving Transformation of US Healthcare. Seminar. Division of Biomedical Informatics, UC San Diego, CA. Mar 2013

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2012 Clinical Registries: Using population data sets to improve healthcare. California HIE Stakeholder Summit (Calif Dept of Public Health). Sacramento, CA. Nov 2012

Interoperability and clinical repositories: UC-ReX – federated querying of multi site Clinical data. Redwood MedNet Annual Conference. Sonoma, CA. Jul 2012.

Integrating health information technology and pathology education. Annual Pathology Chairs conference. Monterey, CA. Jul 2012

2011 Using an HIE as a Community Care Platform. California HIE Stakeholder Summit (Calif Dept of Public Health). Sacramento, CA. Nov 2011

TRANSCEND: Operational Aspects of the I-SPY2 Trial. FDA/DIA Tailored Therapeutics. Bethesda, MD. Oct 2011

Electronic Capture of Patient Information: The Last Mile in Health Information Technology. Bay Area Healthcare IT. Palo Alto, Ca. Aug 2011

Informatics: The Value of a Pathologist. Association of Pathology Chairs Annual Meeting. Monterey, CA. July 2011

"A Community Care Platform". Redwood Mednet Annual Conference. Santa Rosa, CA. July 2011

"Health Information Exchange: A Doctor's View". The State of HIE Conference. Sacramento, CA. April 2011

“When Your Patient Dies”. UC Davis Medical Student Lecture. March 2011.

2010 “TRANSCEND: The Role of Informatics in Complex Clinical Trials”. Georgetown Informatics Seminar. Nov 2010.

"EHR lessons learned: The good, the bad, and the ugly." California Medical Association Leadership Academy. April 2010. San Diego, CA.

"HIT 101: What health information technology means for medical practice -- and why you should care." California Medical Association Leadership Academy. Apri 2010. San Diego, CA

"TRANSCEND: Moving towards agile clinical trials." UC San Diego Cancer Center Informatics Seminar. March 2010. San Diego, CA.

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2009 “Using caBIG to Support Adaptive Clinical Trials”. caBIG NCI Annual Session. Washington DC. Jul 2009

“An Informatics Architecture for Comparative Effectiveness and Practice Change”. Redwood MedNet Annual Conference. Healdsburg, CA. Jul 2009

“TRANSCEND: Informatics and clinical trials”. Personalized Medicine 2.0. San Francisco State University. Jun 2009

“Health Information Technology: An Overview”. Guest Lecture, CITRIS, UC Berkeley, Berkeley, CA Mar 2009

2008 “Clinical Trials in the Age of Personalized Medicine”. UC Davis Department of Pathology Grand Rounds, Sacramento, CA Nov 2008

“Building Software: An Artful Science”. UCSF Breast Cancer Center of Excellence, San Francisco, CA Nov 2008

“Medicine and Web2.0: Blogs, Wikis, Podcasts, PHRs, Oh My! Connecting California to Improve Patient Care 2008. Ukiah, CA July 2008

“Cancer Informatics: Accelerating Cancer Discoveries”.UC Davis Cancer Center Annual Retreat, Sacramento, CA Aug 2008

“Pathology Informatics: An Emerging Discipline”.UC Davis Department of Pathology Retreat. Lake Tahoe, CA. May 2008.

“Social Network Analysis: Evaluating Translational Collaboration.” Health Informatics Program. UC Davis Clinical and Translational Science Center, Apr. 2008

“Here comes molecular medicine: Are EMR’s ready?”. Molecular Medicine tri- conference, San Francisco, CA. Apr 2008.

“An Automated Method to Characterize Medical Informatics Research Themes and Collaborative Networks”. 3rd Annual UC Davis Health Informatics Symposium, Sacramento, CA. Mar 2008.

“Terminologies, data standards, and other Informatics stuff”. Center for Information Technology in Society (CITRIS), Berkeley. Mar 2008

2007

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“Learning to use the Healthcare Internet: A Guide for Patients.”. UC Davis Cancer Center. 2007. Nov. 2007.

“The Internet and cancer: Truth or Tale”. UC Davis Cancer Center Seminar Series. Dec. 2007.

“The Internet and healthcare: An update”.Ukiah, CA. Oct 2007.

“Discerning use of Web-based information for pathology: Wikipedia and beyond.” Association of Pathology Chairs Annual Meeting. Colorado Springs, CO. Jul 2007.

“Using the UMLS MetaMap as a Cause of Death Analyzer.". NAPHSIS Annual Conference. Salt Lake City, Utah. Jun 2007.

2006 “When your patient dies”. UC Davis Internal Medicine Resident Lecture Series. UCDMC. Sacramento. Nov 2006.

“Public Health Informatics: An Overview". Data Policy Access Committee, California Department of Health Services. Nov 2006.

“Mortality Statistics: Understanding Death”. Longevity Course, UC Davis. Apr 2006.

“The California Electronic Death Registration System: Building and Deploying a Mission Critical System for California.”. Health Informatics Seminar, UCDMC, Sacramento. Jan 2006.

2005 “The Electronic Health Record of the Future: Integrating Molecular Information”. Data Integration in the Life Sciences (DILS) Conference, San Diego. Jul 2005.

“The Biophotonics Network: Using Social Network Analysis to Characterize Scientific Collaboration in Biophotonics”. UCD Center for Biophotonics Annual Meeting. Squaw Valley, CA. Jul 2005.

“Remote Attestation of Death Certificates in California”. NAPHSIS Annual Meeting, Cincinnati. Jun 2005.

2004 “From Data to Information: Automating Death Certificate Registration in California” California Public Health Association Joint Annual Meeting. Oakland , CA. Apr 2004.

“Illuminating Pathways to Collaborative Scientific Discovery". Lawrence Livermore National Laboratory Science Seminar, Livermore CA. Nov 2004.

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“Introduction to the California Electronic Death Registration System". California Coroner’s Association, San Diego. Aug 2004.

“The Biophotonics Roadmap: Knowledge Mining in a Scientific Community”. Annual Conference of the UC Davis Center for Biophotonics, Davis, Jun 2004

“Medical Informatics 101”. USC School of Business Healthcare Information Technology Lectures. Sacramento. Jun 2004.

“Public Health Informatics”. USC School of Business Healthcare Information Technology Lectures. Sacramento. Jun 2004

“Clinically Relevant Open Source Software: The CROSS Project”. UCSF Breast Cancer Center of Excellence Annual Conference, San Francisco. May 2004.

“Introduction to caMATCH: A clinical trials matching system”. UCSF Breast Cancer Center of Excellence Annual Conference, San Francisco. May 2004.

“Introduction to Electronic Death Registration”.California Annual Conference of Local Health Officers, Yosemite, CA. May 2004.

“Medical Informatics and Pharmacists”. Ohio State University School of Pharmacy PHR721D Course. Lecture conducted over the Internet using Voice-over-IP and whiteboard technology from, Sacramento. Mar 2004.

“Cutting-Edge Technology: A Medical Odyssey”. UC Davis Coming of Age Lecture Series, Sacramento, CA. Apr 2004.

2003 “Computerized Provider Order Entry: The Problem and Possible Solutions”. Annual Meeting of the California Society of Health-System Pharmacists. Sacramento. Oct 2003

“Building an ontology for neurosciences: the pragmatics of knowledge representation in a scientific discipline". UC Davis Dept. of Pathology Grand Rounds. May 2003.

“Moving Towards Computer Based Patient Record Systems”. USC School of Business Healthcare Information Technology Lectures. Sacramento. Apr 2003.

“Medical Informatics: An Introduction”. USC School of Business Healthcare Information Technology Lectures. Sacramento Apr 2003.

2002

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“A Framework for Open Development of Terminologies”. HL-7 Vocabulary TC Meeting, Boston. Aug 2002.

“Building a Semantic Web for Neuroscience”. Sun MicroSystems Computational Biology Symposium, Santa Clara, CA. Oct 2002.

“Informatics for Medical Technologist". Annual Meeting of the California Association of Medical Laboratory Technologists (CAMLT). Anaheim, CA. Oct 2002.

2001 “jTerm: A Healthcare Terminology Server”. TEPR Conference, Boston, MA. May 2001.

“Caught in the Medical Web”Doctor’s Hospital Annual Trauma Conference, Doctor’s Hospital, Modesto. May 2001.

2000 “Linking images to knowledge with concept-based mediation: Telepathology 2000”. UC Davis Medical Center. Aug 2000.

“Role of Informatics in Medicine”. UC Davis Neurology Grand Rounds, Sacramento. July 2000

“The Art of Medicine: Making Decisions Under Uncertainty”. UC Davis Pathology Course Lecture. May 2000.

“Using the web and telemedicine to improve women’s health”. UC Davis Women’s Health Mini-school, Sacramento, CA. Mar 2000.

1999 “Medical terminology systems for the 21st century”. Center for Health Services Research Seminar Series, UC Davis Medical Center. Sacramento. May 1999.

1998 “Medicine in the Information Age” Marshall Hospital Grand Rounds, Placerville, CA. Aug 1998

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INFORMATICS PROJECTS

pSCANNER (2014-present) http://pscanner.ucsd.edu/ Role: UC Davis Principal Investigator pSCANNER is a PCORI funded Clinical Data Research Network (CDRN). pScanner involves over 20 institutions and 30 million patient records. pSCANNER has implemented both OMOP and PCORNet common data models (CDMs). Aggregate clinical data queries are available to role-appropriate approved individuals who can issue queries across the network using the Lincoln Peak PopMedNet client.

MARYLAND ELECTRONIC DEATH REGISTRATION SYSTEM (2014-present) Role: Principal Investigator, Chief Informatics Architect. Led the team that developed a modern electronic death registration system for Maryland. Delivered and deployed January 1, 2015.

INSPIRE – INteroperability to Support Practice Improvement, Disease REgistries, and Care Coordination (2013-2014) Role: Co-Principal Investigator. A project focusing on improving the capture of clinical data for high impact conditions (ie, cancer). The system seeks to (1) improve coordination of care, (2) support near real-time distributed querying of clinical data sets for quality measures, and (3) improve the data quality and completeness of clinical data.

ATHENA BREAST HEALTH NETWORK PLATFORM (2012-present) http://www.athenacarenetwork.org Role: Chief Medical Information Officer, Founding Member. The Athena is a multi-institutional project designed to gather data from women (healthy and those with breast cancer) over time to support research and quality improvement. The project currently involves 6 University of California campuses (UCD, UCLA, UCSF, UCSD, UCI, UCB). Athena was featured in Marc Benioff’s DreamForce 2015 keynote (https://youtu.be/liW6QrZs4A8).

ATHENA HEALTH QUESTIONNAIRE SYSTEM (HQS) (2012-present) Role: Co-Designer, Informatics Dir. A web platform designed for collection of electronic patient reported information (ePRI). The system was developed using the Salesforce Platform as a Service (Force.com), and has been integrated with electronic health record systems using an

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Interface Engine (MIRTH Corp). The system includes breast risk cancer prediction models implemented as web-service enabled decision support components, accessible to the HQS system, and rendering a score/report sent to EHRs using HL-7 messages through an Interface Engine.

ATHENA iPAD app (2012) Role: Co-architect, co-designer. A native iOS application designed for electronic patient reported information (ePRI) collected in a clinic setting. One of the first "survey/questionnaire" systems to implement questions, skip/branch logic, and language/translation as an XML schema, which is then interpreted by the native application to render and execute the questionnaire. Co- developed iOS app with Tonic Health (https://www.tonicforhealth.com), which has since used it as the basis of a commercial product. TonicHealth video - https://youtu.be/2T-JDEm8Zgk

UC-REX - University of California Research eXchange (2010) http://www.ucrex.org Role: Founding Member (2010-present); Chair (2012-2013); UC-ReX has the goal of creating a searchable federated data repository across the 5 Univ. of California academic medical centers. The systems implement the i2b2 SHRINE network across multiple i2b2 nodes providing query capability across 11.8 million patient records.

MOJO NLP (2010) Role: Original designer, development lead. The MOJO Natural Language Processing system implements a Java Spring based framework to pipeline NLP functionality. The system includes a variety of functions including Input phrase normalization, tokenization, abbreviation identification, Part of Speech Tagger (POS Tagger), and a “Mapper” to match input phrases with reference phrases in controlled vocabularies. The system has been successfully used to auto-code causes of death on death certificates as well as diagnosis phrases in surgical pathology reports.

TRANSCEND2 (2012) Role: Architect, Director of Informatics/development A continuation of TRANSCEND 1. Originally, electronic data capture was accomplished through a modified open-source clinical information system (Tolven). Since Feb 2012, the EDC function was re-implemented the Salesforce Force.com platform. Integration was originally implemented with caExchange but has been transitioned to caHUB. The system implements a novel web-services based automated randomization system (SMART) that integrates with the EDC component using web services. TRANSCEND2 has improved integration capability with prevailing EHRs using HL-7v2, CCD, enhanced CDA, and HL-7v3 messages. The

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system includes reporting (Pentaho) and a RDF repository (Virtuoso). It also implements single-sign-on (SSO) through CAS. Remote data capture using the IHE QRPHCa XML-XFORMS based profile was implemented to demonstrate the feasibility of remote data capture (RDC) using this technique and standard.

TRANSCEND1 (2009). Role: Architect, Director of Informatics/development. TRANSCEND (TRANslational Informatics System to Coordinate Emerging Biomarkers, Novel Agents, and Clinical Data ) is an informatics platform to support paperless clinical trials. The system is currently used to automate the I-SPY 2 Breast Cancer Trial. The system uses a number of caBIG components including caTissue, caARRAY, and caINTEGRATOR.

CALIFORNIA ELECTRONIC DEATH REGISTRATION SYSTEM (2004) http://www.edrs.us Role: Principal Investigator, Chief Informatics Architect. CA-EDRS is the largest and most active electronic death certificate systems in the US. It was developed in 13 months as a secure, web-based, J2EE system. Deployed Jan 1, 2005, it continues to be the system used by California for death registration. Today, California processes 99% of all death certificates electronically through the system.

WARFDOCS (2003) (one of the first PalmOS clinical decision support systems in healthcare) Role: Co-designer, supervised development, Co-PI on a study using the system WARFDOCS is a Bayesian warfarin predictive dosing system built originally on the PalmOS and used in a multi-hospital RCT to determine the effect of its use as a decision support system for in-hospital pharmacists. The system was subsequently re- implemented in J2EE as a web-based RESTful service.

MYINFOVAULT (2002) (formerly the Mission Based Reporting System) http://myinfovault.ucdavis.edu Role: Co-designer, supervised development MyInfoVault is a system originally developed as the “Mission Based Reporting (MBR) System” to provide a method of measuring academic advancement and productivity. The system was subsequently transitioned to the UC Davis Information and Education Technology (IET) and enhanced to become a faculty dossier management system to computerize the promotion/advancement process. The system is currently used by multiple departments and schools at UC Davis:

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ORACLE HTB (2000) Role: Product Manager for Enterprise Terminology Services (ETS) Oracle Healthcare Transaction Base (HTB) is core foundational platform for healthcare information systems. It is built on Oracle technology including the Oracle RDBMS, and Oracle’s J2EE app server. The system implements an HL-7 v3 RIM based information model. The ETS component provided service-oriented terminology functionality.

CRC – The Clinical Resources Center (1997-present; still in use at UCDMC) (one of the first web portals in the world) http://ecrc.ucdmc.ucdavis.edu Role: Original designer, led development and managed the system for a number of years. The Clinical Resources Center (CRC) is a web-based portal system focused on providing clinical knowledge at the point of care. It was one of the first ‘portal’ systems -- built in 1995. It was also one of the first web-based applications to be built using the Java Servlet API. Today, it has been transitioned to the UCDHS Health Information Systems group and enhanced. It is routinely used by over 5,000 UC Davis Health System faculty and staff.

jTerm (1997) (one of the first open source terminology servers) Role: Original designer, developer jTerm was the first open-source terminology server in 1999. It implemented both Java RMI interfaces as well as a declarative language interface (Terminology Query Language – TQL). The system provided integrated access to both UMLS and SNOMED RT.

ODYSSEY (1997) (a custom web browser for healthcare) Role: Original designer, development lead. Odyssey was an experimental custom built web browser that implemented the NetManage HTML rendering engine. It was designed as a limited browser for semi- public spaces (ie, hospital areas) and had administrative authentication capability to manage the functionality offered the end-users (ie, openURL, print, etc..). It was the first browser to implement a “bookmark bar” in the form of Quick Links to systems of interest such as PubMed.

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QD-POP (1996) (one of the first ‘web email’ systems on the internet) Role: Original designer, co-developer. QD-POP was one of the first web based front-ends to POP email systems in the world. It was implemented using a Perl Common Gateway Interface (CGI) library and a Perl based POP3 library providing access to POP3 protocol commands.

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MEMBERSHIPS Fellow, American College of Physicians (ACP) Member, American Public Health Association (APHA) Member, American Medical Informatics Association (AMIA) Member, National Association of Public Health Statistics and Information Systems Member, California Medical Association (CMA)

PROFESSIONAL and COMMUNITY SERVICE

Dept. of Health Services Medicaid Information Architecture Board 2017 - Advisory committee. Leveraging Data 2017-Empowering Data Driven 2017 Government. Organizer and Advisor, Health Technology Forum (Bay Area Chapter) 2012 - http://www.healthtechnologyforum.com Remote Data Capture (SDC) Workgroup, S&I Framework 2013-2016 Co-Chair, Research and Technology Sub-Committee 2009-2010 California Department of Public Health Strategic Planning Committee Advisor, Redwood MedNet Health Information Exchange, Ukiah, CA 2008-2011 Open Source Working Group, American Medical Informatics Association 2003-2010 Vocabulary Technical Committee, Health Level – 7 (HL-7) 2002-2005 Commission on Pain Management, HCRI Institute 2002-2005 College of American Pathologists SNOMED RT advisory group 2001-2002 Quality Data Information System Project Advisor, Western Health 1999-2000 Advisor, University Pathology Consortium (UPC) 1998-2000 Pharmacy Working Group, California CALINX project 1998-1999 Internet Working Group, American Medical Informatics Association 1996-1998

OTHER EXPERIENCE ORACLE Corporation (2000-2001) Redwood Shores, CA Healthcare Transaction Base (HTB) Development Group Role – Took a 1-year leave-of-absence from the University of California to join the ORACLE Healthcare Group and develop a health information technology platform. Had overall responsibility for designing and leading the development of a terminology services component (Enterprise Terminology Services – ETS)

LiveSoftware, Inc. (1999-2001) Cupertino, CA Role – Technical advisor to LiveSoftware (Cupertino, CA) on a J2EE application server (JRun). Innovations included “taglets” -- custom tags in the Java Server Pages (JSP) specification. Given a Commendation of Excellence for contributions to JRun. LiveSoftware was acquired by Allaire/Macromedia in 2001. LiveSoftware was the first to implement a J2EE “servlet” engine.

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Lippincott-Raven Publishing(1998) Sacramento, CA Role – Advisor/consultant on developing an electronic publishing strategy for the web. Commissioned to write a white paper on web-based publishing of biomedical content on the web and its role in knowledge delivery at the point of care.

New Wind Publishing (1996-1999) Sacramento, CA Role – Co-founder of New Wind Publishing. Co-authored and published the first book on the Internet and Healthcare. The first edition was translated into 5 languages (Russian, Portuguese, Spanish, Farsi, Polish) and was distributed to over 100,000 individuals worldwide. A review -- http://annals.org/article.aspx?articleid=710720

St. Joseph’s Hospital (1987) Houston, TX Role – Staff – hyperthermia unit. Assisted an RN in treating cancer patients with a NASA-built RF hyperthermia unit. Provided basic nursing care, transport, and operated the RF hyperthermia system to deliver experimental adjuvant heat therapy. Went on patient rounds as part of the care team. Assisted surgeons in the OR with hyperthermia infusions. Resigned in May 1987 to enroll in medical school.

Stehlin Foundation for Cancer Research (1986) Houston, TX Role – Bioengineering Staff. Developed radiofrequency hyperthermia systems for research in cancer. Programmed a real-time data acquisition interface for a fiber-optic thermocouple (8088 Assembly Language, BASIC).

Electronic Data Systems (EDS) (1985-1986) Dallas, TX Role – Systems Engineer, Quality Assurance Team, Medicare Services Division. Tested mainframe software intended for Medicare claims processing and Utilization Review of healthcare services using claims data.

Stehlin Foundation for Cancer Research (1983-1985)Houston, TX Role – Bioengineering cooperative education intern. Developed radiofrequency hyperthermia systems for research in cancer. Programmed a real-time data acquisition interface for a fiber-optic thermocouple (8088 Assembly Language, BASIC)

INFORMATICS and TECHNICAL PROFICIENCY

Healthcare Informatics --- Health information exchange infrastructures, HL-7 v2.x, HL- 7v3, CDA-R2, Consolidated CDA (CCDA). Terminological systems and interfaces (HL-7 CTS-2, CORBA LQS, etc...). caBIG components including caTissue, caINTEGRATOR, iHub (formerly caExchange), caARRAY, caAERS.

Ontologies and classification systems – LOINC, SNOMED CT, NLM’s UMLS (Metathesaurus, Semantic Network, and Lexical tools – MetaMap), ICD/CPT. Protege, Semantic Web technology. Designed and built the first open source web- enabled terminology server (jTerm).

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Business Intelligence – Have implemented Pentaho Enterprise to provide BI and dashboards for California Vital Records. Have also worked with Business Objects in delivering registry dashboards to clinicians and researchers using the UCD Tethered Meta-Registry.

Information Infrastructure –J2EE-based infrastructures and frameworks including Servlet API, Struts, Spring, and Seam. Past reviewer of O’Reilly technical book on Java Servlet API.

Mobile/mHealth – Experience with development, provisioning, and deployment of iOS healthcare applications for iPad.

Data infrastructures – Experience with ORACLE, MySQL, PostgreSQL, and PostGIS (a GIS implementation of PostgreSQL). Some familiarity with Map/Reduce and Hadoop. Some experience with Amazon AWS “EMR” (Elastic Map Reduce).

Cloud Infrastructure -- Salesforce/Force.com development (Force.com APEX development). Amazon EC2, RDS. Rackspace, Amazon EC2 AWS.

Technical/Programming Languages – Java, JSP, XML, ANSI92 SQL, x86 Assembly Language

Modeling – UML, relational database entity-relationship diagrams (ERDs)

Page 31

Kathryn A Hollenbach, PhD, MPH Division of Emergency Medicine – Mail Code 5075 Rady Children’s Hospital, 3020 Children’s Way San Diego, CA 92123 858-966-1700 ext. 3514 [email protected]

12765 Chaparro Hills Place San Diego, CA 92130 858-523-1326 home [email protected]

Academic Degrees

May 1980 A.B. Psychology Boston College Chestnut Hill, MA August 1985 M.P.H. Health Promotion San Diego State University San Diego, CA June 1990 Ph.D. Epidemiology University of Washington Seattle, WA

Positions and Employment

1989-1990 Epidemiology/Statistical Consultant, Adeza Biomedical, San Jose, CA.

1990-1991 Staff Research Associate, Department of Community and Family Medicine, University of California, San Diego, La Jolla, CA.

1991-1998 Assistant Adjunct Professor, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA.

1991-1999 Graduate School of Public Health Cabinet Member, San Diego State University, San Diego, CA.

1997-1999 Coordinator, San Diego State University-University of California San Diego Joint Doctoral Program in Public Health (Epidemiology).

1998-2010 Associate Adjunct Professor, Department of Family and Preventive Medicine, University of California, San Diego. La Jolla, CA.

2010-present Principal Consultant & Owner, BetaStatistics, LLC, San Diego, CA.

2010-2015 Lecturer, Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, CA.

2015-present Volunteer Associate Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

2017- present Senior Research Associate, Division of Emergency Medicine, Department of Pediatrics, University of California San Diego, Rady Children’s Hospital San Diego, CA.

Courses Designed and Taught

1991-1993 Perinatal Epidemiology (co-designed and taught) University of California San Diego School of Medicine

1993-1995 Advance Applied Epidemiology Methods San Diego State University - University of California San Diego Joint Doctoral Program in Public Health (Epidemiology).

2003-present Biostatistics Skaggs School of Pharmacy and Pharmaceutical Sciences, University of of California San Diego.

Mentored Junior Faculty/Fellow/Resident/Graduate Student Research Projects

1992 – 2009 University of California San Diego School of Medicine

1992 – 2010 San Diego State University - University of California San Diego, Joint Doctoral Program in Public Health (Epidemiology)

2011–present Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego

2015–present Division of Emergency Medicine, Department of Pediatrics, University of California San Diego

2018–present California Pharmacy Student Leadership (CAPSLEAD) Faculty

Doctoral Disseration Chairs – San Diego State University-University of California, San Diego Joint Doctoral Program in Public Health (Epidemiology). 1999 Ruth Bush 2003 Karen Ferran 2004 Samantha Tweeten 2010 Debra Poeltler

Honors and Awards

1985 Outstanding Graduate Student, Division of Health Promotion, San Diego State University, San Diego, CA.

1985 Outstanding Graduate Student, Graduate School of Public Health, San Diego State University, San Diego, CA.

1985 John Hanlon Award, San Diego State University, San Diego, CA.

1989 Best Genetic Paper, Society of Perinatal Obstetricians, New Orleans, LA.

2003 (supervised) San Diego Epidemiology Research Exchange 2003 Student Research Award – awarded to Karen Ferran, San Diego, CA.

2003 Outstanding Teaching Award, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

2014 Excellence in Teaching Award, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

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Contracts and Grants

Principal Investigator. Relationship Between Tobacco Use and Abruptio Placentae. TRDRP July 1993 - June 1995.

Principal Investigator. Outpatient Stem Cell Transplants for Breast Cancer. BCRP. July 1998 – June 1999.

Co-Principal Investigator. A RCT Plant Based Diet and Breast Cancer Recurrence. NCI/NIH. July 1998 – October 2002.

Principal Investigator. Risk Factors for Skiing and Snowboarding Injuries. UCLA- subcontract.

Co-Investigator. DHEA Replacement in Healthy Older Men and Women. NIA. September 2000-August 2005.

Co-Investigator (non-salaried). Identification of Environmental and Nutritional Risk Factors for Neural Tube Defects Along the California/Baja Boarder (A Pilot Study). Southwest Center for Environmental Research and Policy. June 1998-May 1999.

Co-Investigator. Review of Volume Sonographic Studies Across Networks. Society of Radiologists in Ultrasound. March 1998 – February 1999.

Principal Investigator. A RCT Plant Based Diet and Breast Cancer Recurrence. December 2002-November 2007.

External Professional Activities

Consultant, Perinatal Research Forum, Sharp Mary Birch Hospital – 1998-1999.

Reviewer, American Cancer Society/Institutional Research Grants – 1999.

Reviewer, Society Academic Emergency Medicine Abstracts – 2016.

Reviewer, Journal of Trauma – 2018.

External Community Activities

President, Ashley Falls Site Council. Del Mar Union School District. 1998-1999.

President, International Cooperative Nursery School Board, University of California San Diego. 1998-1999.

Member, Del Mar Union School District Boundary Committee, 2001.

Member, Teen Volunteers in Action. 2010-2013.

Member, Torrey Pines Foundation. Del Mar Union School District, 2012-2013

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Peer-Reviewed Publications

Sleet DA, Hollenbach KA, Hovell MF. Applying behavioral principles to motor vehicle occupant protection. Ed Treat Child 9(4):320-33, 1986.

Hickok DE, Hollenbach KA, Reilley SF, Nyberg DA. The association between decreased amniotic fluid volume and treatment with nonsteroidal anti-inflammatory agents for preterm labor. Am J Obstet Gynecol 160:1525-31, 1989.

Hollenbach KA, Hickok DE. Epidemiology and diagnosis of twin gestation. Clin Obstet Gynecol 33:3-9, l990.

Verreault R, Weiss NS, Hollenbach KA, Strader CH, Daling JR. Use of electric blankets and risk of testicular cancer. Am J Epidemiol 131(5):759-62, l990.

Voigt LF, Hollenbach KA, Krohn MA, Daling JR, Hickok DE. The relationship of abruptio placentae with maternal smoking and small for gestational age infants. Obstet Gynecol 75:771-4, l990.

Nyberg DA, Resta RG, Hickok DE, Hollenbach KA, Luthy DA, Mahony BS. Femur length shortening in the detection of Down syndrome: Is prenatal screening feasible? Am J Obstet Gynecol 162:1247-1252, 1990.

Luthy DA, Wardinsky T, Shurtleff DB, Hollenbach KA, Hickok DE, Nyberg DA, Benedetti TJ. Elective cesarean section improves outcome of meningomyelocele. NEJM 324:662- 6, 1991.

Kramer MD, Taylor V, Hickok DE, Daling RJ, Vaughan TL, Hollenbach KA. Maternal smoking and placenta previa. Epidemiol 2:221-3, 1991.

Cheng EY, Luthy DA, Hickok DE, Hollenbach KA, Resta RG, Mahoney BS, Luthardt FW. Transcervical chorionic villus sampling and midtrimester oligohydramnios. Am J Obstet_Gynecol 165:1063-1068, 1991.

Ralston ME, Choplin NT, Hollenbach KA, Applegate BJ, Henn TW. Glaucoma screening in primary care: The role of noncontact tonometry. J Fam Pract 34:73-77, 1992.

Kritz-Silverstein D, Barrett-Connor E, Hollenbach KA. Pregnancy and lactation as determinants of bone mineral density in postmenopausal women. Am J Epidemiol 1992;136:1052-1059.

Hollenbach KA, Barrett-Connor E, Edelstein SL, Holbrook T. Cigarette smoking and bone mineral density in older men and women: A prospective population-based study. Am J Pub Hlth 1993;83:1265-1270.

Karagas MR, Hollenbach KA, Hickok DE, Daling JR. Induction of labor and risk of sudden infant syndrome. Obstet_Gynecol 1993;81:497-501.

Piacquadio DJ, Rad FS, Spellman MC, Hollenbach KA. Obesity and female androgenic alopecia: A cause and an effect? J Amer Academy Dermatol 1994;30:1028-1030.

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Peer-Reviewed Publications (continued)

Pretorius DH, House MH, Nelson TR, Hollenbach KA. Evaluation of normal and abnormal lips in fetuses: Comparison between three- and two-dimensional sonography. AJR 1995;165:1233-1237.

Pretorius DH, Chau C, Poeltler DM, Mendoza A, Catanzarite VA, Hollenbach KA. Placental cord insertion visualization with prenatal ultrasound. J Ultrasound Med 1996;15:585-593.

Fullerton J, Hollenbach KA, Wingard D. Practice styles: A comparison of obstetricians and certified nurse-mid-wives. J Nurse-Midwifery 1996;41(3):243-250.

Piacquadio D, Dobry M, Hunt S, Andree C, Grove G, Hollenbach KA. Short contact 70% glycolic acid peels as a treatment for photodamaged skin - a pilot study. Dermatol Surg 1996;22:449-452.

Nagotte MP, Larson D, Rumney PJ, Sidhu M, Hollenbach K. Epidural analgesia compared with combined spinal-epidural Analgesia during labor in nulliparous women. NEJM 1997;337:1715-1719.

Meisenberg BR, Ferran K, Hollenbach K, Brehm T, Jollon J, Piro LD. Reduced charges and costs associated with outpatient autologous stem cell transplantation. BMT 1998;21:927-932.

Conrad JK, Hollenbach KA, Fullerton JT, Feigelson HS. Use of prenatal services by Hispanic women in San Diego County. J Nurse-Midwifery 1998;43:90-96.

Rock CL, McEligot AJ, Flatt SW, Sobo EJ, Wilfley DE, Jones VE, Hollenbach KA, Marx RD. Eating pathology and obesity in women at risk for breast cancer recurrence. Int J Eat Disord 2000;27(2):172-9.

Rock CL, Thompson C, Caan BJ, Flatt SW, Newman V, Ritenbugh C, Marshall JR, Hollenbach KA, Stefanick ML, Pierce JP, Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis: Evidence from a randomized controlled trial. Cancer 2001;91(1):25-34.

Nelson TR, Pretorius DH, Lev-Toaff A, Bega G, Budorick NE, Hollenbach KA, Needleman L. Feasibility of performing a virtual patient examination using three- dimensional ultrasonographic data acquired at remote locations. J Ultrasound Med 2001;20(9):941-52.

Goodman-Gruen D, Hollenbach K. The prevalence of von Willebrand disease in women with abnormal uterine bleeding. J Womens Hlth Gend Based Med 2001;10(7):677-80.

McEligot AJ, Gilpin EA, Rock CL, Newman V, Hollenbach KA, Thompson CA, Pierce JP. High dietary fiber consumption is not associated with gastrointestinal discomfort in a diet intervention trial. J Am Diet Assoc 2002;102(4):549-51.

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Peer-Reviewed Publications (continued)

Pierce JP, Faerber S, Wright FA, Rock CL, Newman V, Flatt SW, Kealey S, Jones VE, Caan BJ, Gold EB, Haan M, Hollenbach KA, Jones L, Marshall JR, Ritenbaugh C, Stefanick ML, Thomson C, Wasserman L, Natarajan L, Gilpin EA, Thomas RG, for the Whel Group. A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: Women’s Health Eating and Living (WHEL) Study. Controlled Clinical Trials 2002;23:728-756.

Pierce JP, Newman VA. Flatt SW, Faerber S, Rock CL, Natarajan L, Caan BJ, Gold EB, Hollenbach KA, Wasserman L, Jones L, Ritenbaugh C, Stefanick ML, Thomson CA, Kealey S, for the Whel Study Group. Telephone counseling intervention significantly increases intakes of micronutrient- and phytochemical-rich vegetables, fruit, and fiber in breast cancer survivors. Journal of Nutrition 2004;134:452-458.

Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Ritenbaugh C, Hollenbach KA, Pierce JP, Chang RJ. Effects of high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. Journal of Clinical Oncology 2004;22:2379-2387.

Natarajan L, Rock CL, Major JM, Tomson CA, Caan BJ, Flatt SW, Chilton JA, Hollenbach KA, Newman VA, Faerber S. Ritenbaugh CK, Gold E, Stefanik ML, Jones LA, Marshall JR, Pierce JP. On the importance of using multiple methods of dietary assessment. Epidemiology 2004;15(6):738-745.

Kahn ST, Flowers C, Lechowicz MJ, Hollenbach K, Johnstone PAS. Refractory or relapsed Hodgkin’s Disease and Non-Hodgkin’s Lymphomia: Optimizing Involved Field Radiotherapy in Transplant Patients. Cancer J 2005;11:425-431.

Thomson CA, Giuliano AR, Shaw JW, Rock CL, Rittenbaugh CK, Hakim IA, Hollenbach KA, Alberts DS, Pierce JP. Diet and biomarkers of oxidative damage in women previously treated for breast cancer. Nutr Cancer. 2005;51(2):146-54.

Rock CL, Flatt SW, Natarajan L, Thomson CA, Bardwell WA, Newman VA, Hollenbach KA, Jones L, Caan BJ, Pierce JP. Plasma carotenoids and recurrence- free survival in women with a history of breast cancer. J Clin Oncol. 2005;23:6631-8.

Pretorius DH, Ji EK, Newton R, Uyan K, Hull AD, Hollenbach KA, Nelson TR. Effect of ultrasound on maternal-fetal bonding: A comparison of two- and three- dimensional imaging. Ultrasound Obstet Gynecol. 2005; 25(5):473-7.

Kahn ST, Flowers C, Lechowicz MJ, Hollenbach KA, Johnstone PAS. Value of PET restaging after chemotherapy for Non-Hodgkin’s lymphoma: Implications for consolidation radiotherapy. Inter J Rad Oncol. 2006; 66(4):961-5.

Bardwell WA, Natarajan L, Dimsdale JE, Rock CL, Mortimer JE, Hollenbach K, Pierce JP. Objective cancer-related variables are not associated with depressive symptoms in women treated for early-stage breast cancer. J Clin Oncol. 2006; 24(16):2420-7.

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Peer-Reviewed Publications (continued)

Pretorius DH, Gattu S, Ji EK, Hollenbach K, Newton R, Hull A. Camona S, D’Agostini D, Nelson TR. Preexamination and postexamination assessment of parental-fetal bonding in patients undergoing 3-/4-dimension obstetric ultrasonography. J Ultrasound Med. 2006; 25(11):1411-21.

Pierce JP, Newman V, Natarajan L, Flatt SW, All-Delaimy WK, Caan B, Emond J, Faerber S, Gold EB, Hajek R, Hollenbach K, Jones LA, Karanji N, Kealey S, Madlensky L, Marshall J, Rittenbaugh C, Rock CL, Stefanick ML, Thomson C, Wasserman L, Parker B. Telephone counseling helps maintain long-term adherence to a high-vegetable dietary pattern. Journal of Nutrition 2007; 137:2291-2296.

Pierce JP, Natarajan L, Caan BJ, Parker BA, Greenberg ER, Flatt SW, Rock CL, Kealey S, Al-Delaimy WK, Bardwell WA, Carlson RW, Emond JA, Faerber S, Gold EB, Hajek RA, Hollenbach K, Jones LA, Karanja N, Madlensky L, Marshall J, Newman VA, Ritenbaugh C, Thomson CA, Wasserman L, Stefanick ML. Influence of a diet very high in vegetables, fruit and fiber and low in fat on prognosis following treatment for breast cancer: The women’s healthy eating and living (WHEL) randomized trial. JAMA 2007; 298(3);298-298.

Rock CL, Flatt SW, Laughlin GA, Natarajan L, Al-Delaimey W-K, Caan BJ, Gold EB, Hajek RA, Hollenbach K, Jones LA, Stefanick ML, Pierce JP. Reproductive steroid hormones and recurrence-free survival in women with a history of breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:1-7.

Hirsch JD, Do AH, Hollenbach KA, Manoguerra AS, Adler DS. Student’s health related quality of life across the preclinical pharmacy curriculum. American Journal Pharmacy Education 2009; 73(8):147.

Taghavi J, Jayarajan SN, Mangi AA, Hollenbach K, Dauer E, Sjoholm LO, Pathak A, Santora TA, Goldberg AJ, Rappold. Examining non-cardiac surgical procedures in patients on extracorporeal membrane oxygenation. Society for Artificial Internal Organs June 2015 [epub ahead of print].

Rappold JF, Hollenbach KA, Santora TA, Beadle D, Dauer ED, Sjoholm LO, Pathak A, Goldberg AJ. The evil of good is better: Making a case for basic life support transport for penetrating trauma victims in an urban environment. J Trauma Acute Care Surg. 2015;79(3):343-348.

Atayee RS, Hur GH, Karimian P, Hollenbach KA, Edmonds KP. Methadone inpatient and discharge prescribing patterns for pain at an academic health system. J Palliative Med, 2017; 20(2):112-113.

Nguyen A, Demirjian A, Yamamoto M, Hollenbach K, Imagawa D. Development of postoperative diabetes mellitus in patients undergoing distal pancreatectomy versus Whipple procedure. Amer Surgeon. 2017;83(10):1050-1053.

Auten JD, Naheedy JH, Hurst ND, Pennock AT, Hollenbach K, Kanegaye JT. Comparison of pediatric post-reduction fluoroscopic- and ultrasound forearm fracture images. Amer J Emerg Med 2018;DOI: 10.1016/j.ajem.2018.07.050. Hollenbach 2/15/19 7

Peer-Reviewed Publications (continued)

Conrad HB, Hollenbach KA, Gehlbach DL, Ferran KL, Barham TA, Carstairs KL. The Impact of Behavioral Health Patients on Pediatric Emergency Department Length of Stay and Left Without Being Seen. Ped Emerg Care. 2018; 34(8) 584-587.

Book Chapters

Hickok DE, Hollenbach KA. Introduction to Obstetrics. In RP Porreco (ed) Contemporary Obstetrics for Medical Students Ithaca,NY: Perinatology Press, 1991.

Invited Reviews and Articles Hollenbach KA, Sleet DA. Resource guide to occupant protection Programs and materials. Health Ed Quarterly 1984;11(2):215-220.

Kritz-Silverstein D, Barrett-Connor E, Hollenbach KA. Re: "Pregnancy and lactation as determinants of bone mineral density in postmenopausal women." The authors reply. Am J Epidemiol 1993;11:1021.

Published Abstracts/Presentations

Hollenbach KA, Sleet DA, Hovell MF. Child passenger protection: A review of child restrain programs and legislation. American Public Health Association. Anaheim, California. November 1984.

Hollenbach KA, Hovell MF, Sleet DA, Conway JB, Heroman WM, Davis CB. Hospital based education and rental programs to increase child passenger protection. American Public Health Association. Washington, DC. November 1985.

Hollenbach KA, Davis CB. Neonatal car safety: Implementation and evaluation of hospital based education and car seat loaner programs. Armed Forces District American College of Obstetrics & Gynecology and the Organization for Obstetrics, Gynecology & Neonatal Nurses Conference. San Diego, California, October 1986.

Emerson JC, Hollenbach KA. A case-control study of selected risk factors for sudden infant death syndrome. Society of Epidemiology Research. Amherst, Massachusetts, June 1987.

Hollenbach KA, Emerson JC. Association between induction of labor and sudden infant death syndrome (SIDS). American Public Health Association. New Orleans, Louisiana, October 1987.

Voight LF, Hollenbach KA, Krohn MA, Daling JR, Hickok DE. Relationship between maternal smoking and abruptio placentae. American Public Health Association. Boston, Massachusetts, November 1988.

Luthy DA, Wardinsky T, Shurtleff DB, Hollenbach KA, Hickok DE, Nyberg DA, Benedetti TJ. Elective cesarean section improves outcome for fetal spina bifida. Society of Perinatal Obstetricians. New Orleans, Louisiana, January 1989.

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Published Abstracts/Presentations (continued)

Hollenbach KA, Hickok DE, Davis CB. Maternal and neonatal complications associated with nonsteroidal anti-inflammatory drugs used for treatment of preterm labor. American Academy of Pediatrics, Anchorage, Alaska, May 1989.

Kramer MD, Taylor V, Hickok DE, Daling JR, Vaughan TL, Hollenbach KA. Smoking and placenta previa. Society for Epidemiologic Research, Birmingham, Alabama, June 1989.

Kramer MD, Taylor V, Hickok DE, Daling JR, Vuaghan TL, Hollenbach KA. Placenta previa, smoking and intrauterine growth retardation. American Public Health Association. Chicago, Illinois, October 1989.

Hollenbach KA, Hickok DE, Mueller BA, McKnight B, Benedetti TJ, Daling JR. Cocaine use as a risk factor for abruptio placentae. Annual Meeting American College of Obstetricians and Gynecologists. San Francisco, California, May 1990.

Karagas MR, Hollenbach KA, Hickok DE, Daling JR. The induction of labor and sudden infant death syndrome (SIDS). Society of Epidemiologic Reseach, Snowbird, Utah, June 1990.

Hollenbach KA, Hickok DE, Mueller BA, McKnight B, Benedetti TJ, Daling JR. Reproductive history and abruptio placentae. Society of Epidemiologic Research, Snowbird, Utah, June 1990.

Shurtleff DB, Luthy DL, Hollenbach KA. Elective prelabor cesarean section improves outcome in fetal memimgomyelocele. Third International Symposium on Spina Bifida, Chicago, Illinois, 1990.

Hollenbach KA, Hickok DE, Daling JR, Mueller BA, McKnight B. Alcohol and tobacco use in pregnancy and abruptio placentae. American College of Obstetricians and Gynecologists District VII-IX Annual Meeting, Seattle, Washington. October 1990.

Cheng EY, Luthy DA, Hickok DE, Hollenbach KA, Resta RG, Mahoney BS. Transvaginal chronic villus sampling and midtrimester oligohydramnios. Society of Perinatal Obstetricians, San Francisco, California. January 1991.

Nageotte MP, Hollenbach KA, Vanderwahl BA, Hutch KM. Oncofetal fibronectin in patients at increased risk for preterm delivery. Society of Perinatal Obstetricians, Orlando, Florida. February 1992.

Hollenbach KA. Substance abuse and smoking: Impact on perinatal outcome. National Conference of Obstetric Nursing. San Diego, California. August 1992.

Foster EE, Hollenbach KA, Poeltler DM, Cousins LM. A comparative study of the effectiveness of multi-disciplinary care for overt and gestational diabetic pregnancies. American Association of Diabetes Educators Annual Meeting, Atlanta, Georgia, 1993.

Ralston ME, Kilgore MA, Davis CB, Hollenbach KA, Heroman WM, Jones KL. Lack of sensorineural hearing impairment in neonates with preauricular pits and tags. Society for Pediatric Research, Washington, DC. May 1993. Hollenbach 2/15/19 9

Published Abstracts/Presentations (continued)

Piacquadio DJ, Hollenbach KA, Spellman MC, Shaw VP. The vasoconstriction assay: Assessment and standardization of quantitative measurement techniques. American Academy of Dermatology, Washington, DC, July 1993.

Hollenbach KA. Relationship between tobacco use and abruptio placentae. Tobacco Related Disease Research Program First Scientific Conference. San Francisco, California, December 1993.

Piacquadio DJ, Spellman MC, Hollenbach KA, Bromgoole SH, Killey F. Potency classification of Cordran tape using the vasoconstrictor assay. American Academy of Dermatology, San Francisco, California. December 1993.

Poeltler DM, Hollenbach KA, Foster EE, Cousins LM. A comparative study (team vs non-team managed) of diabetes pregnancy care. San Diego Biostatistics and Epidemiology Research Exchange, San Diego, California, 1994.

Bush R, Hollenbach K, Barrett-Connor E. The long-term effects of extreme athleticism on bone mineral density. Society Epidemiology Research, Baltimore Maryland, June 1999.

Ferran K, Hollenbach K, Slymen D, Moore T, Wingard D, Patrick K, Goodman-Gruen D. Hypertension and mortality among women with a history of new onset hypertension ddruing pregnancy. San Diego Biostatistics and Epidemiology Research Exchange, San Diego, California, 2003.

Johnson-Kozlow M, Pierce JP, Gilpin EA, Rock CL, Hollenbach KA. Validity and measurement bias in three self-report measures of physicial activity among women diagnosed with breast cancer. San Diego Biostatistics and Epidemiology Research Exchange, San Diego, California, 2004.

Quartarolo J, Lu C, Hollenbach K. Identifying patients at high risk for medication history errors at the time of hospital admission. 2010 Society of Hospital Medicine Annual Meeting Washington, DC. 2010.

Chin A, Esner M. Jabaiah S, Kim E, Meng T, Meunier K, Yoon C, Zhou C. Desire, demand and availability of postgraduate pharmacy residency training in California. California Society of Health-System Pharmacists (CSHP). Las Vegas, Nevada, October 2012 (Faculty Advisor).

Rappold JF, Hollenbach KA, Lloyd ME, Sjoholm LO, Santora TA, Jujon J, Pathak AS, Goldberg AJ. 1:1:1 A matter of life and death. American Association for the Surgery of Trauma, San Francisco, California, September 2013.

Rappold J, Hollenbach K, Santora T, Beadle D, Dauer E, Sjoholm L, Pathak A, Goldberg, A. The evil of good is better: Making the case for basic life support transport in penetrating trauma victims in an urban environment. American Association for the Surgery of Trauma, Philadelphia, Pennsylvania. September 2014.

Hollenbach 2/15/19 10

Published Abstracts/Presentations (continued)

Lubitz A, Hollenbach K, Chan E, Dauer E, Sjoholm L, Pathak A, Santora T, Goldberg A, Rappold J. Old blood and complications in massively transfused trauma patients: A cautionary tale. Academic Surgical Congress, Las Vegas, NV. February 2015.

Taghavi S, Jayarahan S, Mangi A, Hollenbach K, Dauer E, Sjoholm L, Pathak A, Santora T, Goldberg A, Rappold J. Examining non-cardiac surgical procedures in patients on extracorporeal membrane oxygenation. ASAIO, June 2015.

Tomboc N, Hatfield J, Hensic L, Normandin B, Hollenbach K. Evaluation of psychiatric versus non-psychiatric interventions performed in an inpatient psychiatric facility. American Pharmacists Annual Meeting, Baltimore, Maryland, March 2016.

McDaniel M, Shah S, Hollenbach KA, Putnam K, Ryu J, Carstairs K. Use of an asthma pathway to improve asthma management in a pediatric emergency department. Society of Academic Medicine Western Regional Meeting. Marina Del Rey, California, April 2016.

Carstairs KL, Hollenbach KA, Shah SD, Weber R, Black I, McDonough L, Lopez B Kaufman I, Davis CB: Improved emergency department quality metrics and patient satisfaction scores following implementation of lean flow principles and queuing theory- based operational changes. Quigley Clinical Research Symposium, San Diego, California, October 2015 and Pediatric Academic Societies Annual Meeting, Baltimore, Maryland. May 2016.

Rudolph F, Hollenbach KA, Carstairs KL, Carstairs SD: Retrospective review of antipsychotic medications administered to mental health patients in a tertiary care pediatric emergency department. 7th Annual UCSD Pediatric Research Symposium, San Diego, California, April 2016 and j.annemergmed.2016.08.254

Shah SD, Hollenbach KA, McDaniel, MA, Ryu J, Carstairs KL: Use of an asthma pathway to improve asthma management in a pediatric emergency department. 7th Annual UCSD Pediatric Research Symposium, San Diego, California, April 2016 and Western SAEM, April 2016.

Williams A, Bonsu B, Johnson A, Pommert K, Hollenbach KA, Kanegaye JT. Tablet computer as a distraction tool during facial laceration repair: A randomized trial. Poster presentation, Pediatric Academic Societies Annual Meeting, Baltimore, Maryland. May 2016.

Carstairs KL, Hollenbach KA, Shah SD, Weber R, Black I, McDonough L, Lopez B, Kaufman I, Davis CB: Improved Emergency Department Quality Metrics and Patient Satisfaction Scores Following Implementation of Lean Flow Principles and Queuing Theory-Based Operational Changes. Invited presentation SAEM, New Orleans, Louisiana, 2016.

Nguyen MB, Hollenbach K, Vigilante J, Fisher M, Lyons J, Weglowski J, Hunter W, Awai H, Carstairs KL. Improved Outcomes for Pediatric Respiratory Patients Treated in a Pediatric Emergency Department Observation Unit DOI: 10.1016 j.annemergmed. 2016.08.250.

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Published Abstracts/Presentations (continued)

Carstairs KL, Nguyen MB, Fisher J, Vigilante m, Weglowski J, Hunter W, Lyons J, Awai H, Hollenbach K. Pediatric Emergency Department Observation Unit Improves Emergency Department and Hospital Flow and Capacity During Highest Census Months DOI: 10.1016 j.annemergmed. 2016.08.199.

Auten J, Pennock A, Naheedy J, Hurst N, Hollenbach KA, Kanegaye JT. Ultrasound- and Fluoroscopy-Guided Reduction of Pediatric Forearm Fractures: A Prospective Observational Study. American College of Emergency Physicians Research Forum, Las Vegas, Nevada, October 2016 and American Academy of Pediatrics National Convention and Exhibition, San Francisco, California, October 2016.

Wai S, Uya A, Zimmerman E, Ratnayake K, Hollenbach K, O’Donnell S, Cannavo C. The Effectiveness of a Pediatric Emergency Medicine Block Education Session for Pediatric Residents. Presented in poster format at 8th Annual Pediatric Research Symposium, Rady Children’s Hospital San Diego, California, January 2017. Presented as a table top discussion at the Academic Pediatrics Association Region 9 and 10 Meeting, Monterey, California, February 2017.

Conrad H, Hollenbach K, Lucio S, Ratnayake K, Smith K, Metcalf A, Uya A, Zimmerman E, Chao D, Mabra A, Carstairs K. “A Specialized Pediatric Emergency Medicine Track Decreases Computed Tomography in Head Injured Patients.” Presented in poster format at 8th Annual Pediatric Research Symposium Rady Children’s Hospital, San Diego, California, January 2017. Presented as an oral presentation for the APA region 9-10 Meeting February 2017. Presented as poster presentation for Pediatric Academic Societies, San Francisco, California, May 2017.

Conrad H, Hollenbach K, Ghelbach D, Chao D, Maxwell B, Webb L, Mueller S, McDonough L, Rawls T, Ferren K, Barham T, Carstairs K. “The impact of behavioral health patients on pediatric emergency department’s length of stay and left without being seen.” Presented in poster format at 8th Annual Pediatric Research Symposium Rady Children’s Hospital January 2017. Presented as an oral presentation for the APA region 9-10 Meeting February 2017. Presenting as poster presentation for Pediatric Academic Societies, San Francisco, California, May 2017.

Nguyen K, Chen L, Ignatyeva N, Jorgensen-Ponce K, Nijum A, Nguyen A, Patel A, Pham Y, Mnatzaganian C, Hollenbach K, Colbert J. The role of intern pharmacists in implementing innovative and sustainable practices to enhance rates of non-influenza immunizations. Seminar 2017 California Society of Health-System Pharmacists, Las Vegas Nevada. October 2017.

Sun C, Hollenbach K, Cantrell L. Impact of carisoprodol scheduling on abuse and misuse: A retrospective review of California poison control calls from 2008 to 2015. North American Congress of Clinical Toxicology, Toronto Canada, October 2017.

Nguyen K, Chen L, Ignatyeva N, Jorgensen-Ponce K, Nijum A, Nguyen A, Patel A, Pham Y, Mnatzaganian C, Hollenbach K, Colbert J. The role of intern pharmacists in implementing innovative and sustainable practices to enhance rates of non-Influenza immunizations. California Society of Health-System Pharmacists Seminar, Las Vegas Nevada, October 2017. Hollenbach 2/15/19 12

Published Abstracts/Presentations (continued)

Yaphockun K, Smith ML, Hollenbach KA, Shah S, Bryl AW. Internasal fentanyl decreases time to opioid administration in pediatric extremity deformities and burns. Pediatric Academic Societies Annual Meeting, Toronto, Canada, May 2018 and Rady Children’s Hospital 9th Annual Pediatric Research Symposium, May 2018.

Gardiner M, Wilkinson M, Hollenbach K. Interrater reliability of the Pediatric Asthma Score. Pediatric Academic Societies Annual Meeting, Toronto, Canada, May 2018 and Rady Children’s Hospital 9th Annual Pediatric Research Symposium, May 2018.

Shah S, Hollenbach K, Malia J, Ton-That, E, Carstairs, KL. Implementation of a Standardized Depression and Suicidality Screening Tool in a Pediatric Emergency Department. Abstract Presentation Pediatric Academic Societies, Toronto, CAN 2018.

Smith ML, Ferran K, Gehlbach DL, Yaphochkun K, Bryl AW, Hollenbach KA. Intranasal fentanyl vs intravenous opioid use and length of stay in pediatric emergency patients with extremity deformities. 8th Annual Epidemiology Research Exchange, San Diego, CA & Rady Children’s Hospital 9th Annual Pediatric Research Symposium, May 2018.

Gehlbach DL, Ferran KL, Conrad H, Cowell A, Smith ML, Hollenbach KA. “Race/Ethnicity and Head Computed Tomography Use in a Pediatric Emergency Department.” Rady Children’s Hospital 9th Annual Pediatric Research Symposium, San Diego, CA May 2018.

Hollenbach 2/15/19 13

CURRICULUM VITAE JAMES P. KILLEEN, MD

HOME ADDRESS: OFFICE ADDRESS:

4997 Academy Street Department of Emergency Medicine San Diego, CA 92109 UCSD Medical Center Phone: (858) 483-7229 200 W. Arbor Drive Cell: (858) 243-6509 San Diego, CA 92103-8676 E-Mail: [email protected] Phone: (619) 543-6463 Fax: (619) 543-3115

PERSONAL: Born March 7, 1966 in Los Angeles, California

EDUCATION:

Academic: Glendale Community College 1982-87 Glendale, California

1987-90 B.A., Cellular-Molecular Biology California State University, Northridge

Medical School: M.D., University of Southern California 1990-94 Los Angeles, California

Internship: Transitional Program 1994-95 Tufts University Boston Massachusetts

Residency: Department of Emergency Medicine 1995-99 Louisiana State University, Medical Center New Orleans/Charity Hospital

Chief Resident: Department of Emergency Medicine 1998-99 Louisiana State University New Orleans/Charity Hospital

2017 Healthcare Leadership Academy UC San Diego Health

Curriculum Vitae James P. Killeen, MD

EMPLOYMENT:

2015 - Present Faculty Attending Physician, Department of Emergency Medicine, El Centro Regional Medical Center

2012 - Present Clinical Professor of Emergency Medicine University of California, San Diego (UCSD) School of Medicine

1999 - Present Assistant Director, Department of Emergency Medicine, UCSD

1999 - Present Faculty Attending Physician, Hyperbaric Medicine Division, UCSD

1999 - Present Base Hospital Physician, UCSD Medical Center

2000 - Present Director of Informatics, Department of Emergency Medicine, University of California, San Diego

2002 - Present Staff Physician, Hyperbaric Medicine Division, Paradise Valley Hospital

PREVIOUS EXPERIENCE:

2007 - 2010 Associate Clinical Professor of Medicine (Emergency Medicine) University of California, San Diego (UCSD) School of Medicine

1999 - 2007 Assistant Clinical Professor of Medicine (Emergency Medicine) University of California, San Diego (UCSD) School of Medicine

1997 – 1999 Attending Physician, Emergency Department, St. Claude Medical Center, New Orleans, Louisiana

1997 - 1999 Attending Physician, Emergency Department and Hyperbaric Medicine, Jo Ellen Smith Medical Center, New Orleans, Louisiana

1997 - 1999 Attending Physician, Emergency Department, Terrebone General Medical Center, Houma, Louisiana

1998 - 1999 Attending Physician, Emergency Department and Hyperbaric Medicine, Slidell Memorial Hospital, Slidell, Louisiana

-2- Curriculum Vitae James P. Killeen, MD

BOARD CERTIFICATIONS:

2007 Diplomat, American Board of Emergency Medicine 2018 Diplomat, American Board of Emergency Medicine, Recertification 2017 Diplomat, American Board of Preventive Medicine, Clinical Informatics

LICENSURE: California Medical License Number A-68035, 1994-Present Louisiana Medical License Number 11786R, 1994-Present Hawaii Medical License Number 10587, 1999-Present

CERTIFICATION:

Cardiac Pulmonary Resuscitation, March 1996 Advance Trauma Life Support, Instructor, April 1997 Advance Cardiac Life Support, Provider, March 1998 Advance Cardiac Life Support, Instructor, May 1998 Pediatric Advanced Life Support, August 1998 Advance Cardiac Life Support, Provider, March 2008 Pediatric Advanced Life Support, March 2008

AWARDS:

Association of Medical Directors of Information Systems (AMDIS) 2012 Larry L. Sautter Golden Award for Innovation in Information Technology for 2017

PROFESSIONAL SOCIETY MEMBERSHIPS:

American College of Emergency Physicians American Medical Association Massachusetts Medical Society Society for Academic Emergency Medicine Society of Orange County Emergency Physicians Underwater and Hyperbaric Medical Society American Medical Informatics Association

PROFESSIONAL ACTIVITIES

UCSD Director of Clinical Informatics Fellowship 2013 - Present San Diego Health Connect – Chief Medical Officer 2013 - Present California Association of Health Information Exchanges (CAHIE) Co-Chair California Association of Health Information Exchanges (CAHIE) Board Member

-3- Curriculum Vitae James P. Killeen, MD

Member, Editorial Board, Journal of Emergency Medicine specializing in Medical Informatics Member, Editorial Board, Western Journal of Emergency Medicine specializing in Medical Informatics Reviewer, Journal of The Joint Commission specializing in Medical Informatics Reviewer, Journal of American Medical Informatics Association

UNIVERSITY SERVICE:

Pharmacy and Therapeutics Committee 2004-2007 Clinical Systems Administrators Committee 2004- 2012 Clinical Leaders Committee 2012 - Present Medical Records Informatics Committee 2011-Present Faculty Mentor, Faculty Mentor Program, Academic Enrichment Programs, 2009-Present Department of Emergency Medicine Faculty Selection Committee, 2013-Present Department of Emergency Medicine Clinical Operations Committee, 2013-Present Project Prioritization Committee 2014 – Present Medical Records Informatics Committee 2014-Present Department of Bioinformatics Clinical Instructor 2015-Present UCSD Physician Informatics Committee 2016-Present UCSD/UCI Emergency Department Informatics Committee 2016-Present UCSD/UCI Inpatient Governance Committee 2016-Present Medical Director of Urgent Care Services 2016-Present

RESEARCH GRANT FUNDING:

1. Co-Investigator, for project on Emergency Department Crowding & Safety Net Assessment, funded by the Urgent Matters Program, Robert Wood Johnson Foundation, grant # 048545. Amount: $150,000 total ($100,000 technical assistance; $25,000 UCSD project direction, $25,000 safety net assessment).

2. Co-Investigator, for project on Wireless Internet Information System for Medical Response in Disasters, National Institute of Health in junction with University of California, NLM grant # BAA02-103/VMS. Amount: $4.1 million from 2003-2006.

3. Co-Investigator, for Improving Medical Home and Primary Care Access to the Community Clinics Through the Emergency Department (IMPACT ED). Alliance Healthcare Grant, Amount: $25,000 from June 2006.

4. Co-Investigator, for Multi-Center Study of the Impact of Nurse-Patient Ratios on Emergency Department Overcrowding. EMF Grant, Amount: $50,000 from June 2007.

5. Co-Investigator, for project entitled, “San Diego Safety Net Health Information Exchange.” Project funded by Pacificare/United Healthcare, 2008-2011. Amount: $715,000.

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6. Co-Investigator, for project entitled, "San Diego Safety Net Connect." (Safety Net Connect). Project funded by San Diego County, 2008-2010. Amount: $2,100,000.

7. Co-Investigator, for project entitled, “Wireless Internet Information System for Medical Response to Disasters (WIISARD SAGE)” Project funded by National Library of Medicine, 2009-2011. Amount $ 3,763,964.

8. Co-Investigator, for project entitled, "San Diego Beacon Consortium." Project funded by Office of National Coordination (ONC), 2010-2011. Amount: $15,200,000.

9. Principal Investigator for study entitled, “Integrating Environmental Data into a PHR for Asthma Patients”. Funded by the California Health and Human Services Agency, Office of Health Information Integrity, 2013-2014. Amount: $202,079.

10. Co-Principle Investigator, for project entitled, “Exploring emergency room physician’s knowledge and attitudes concerning the use of appropriate and safe home care as an alternative to hospital admission.” Funded by the Gary and Mary West Health Institute, 2014-2015. Amount: $118,021.

11. Co-Principle Investigator, for project entitled, Exploring emergency room physician’s knowledge and attitudes concerning the use of appropriate and safe home care as an alternative to hospital admission. Funded by the Gary and Mary West Health Institute, 7/14 – 2/15. Amount: $123,152.

12. Co-Principle Investigator, for project entitled, Acute Home Care as an Alternative to Inpatient Admission from the Emergency Department. Funded by the Gary and Mary West Health Institute, 9/15 – 8/16. Amount: $499,125.

13. Co-Principle Investigator, for project entitled, The Gary and Mary West Geriatric Center of Excellence (West COE): Phase 1 Research Development. Funded by the Gary and Mary West Health Institute, 9/15 – 3/16. Amount: $243,610.

14. Co-Investigator for study entitled, “Mitigating Legal Risk in the Emergency Department: A UC Health System-Wide Collaboration”. Funded by the Center for Health Quality and Innovation, University of California, Office of the President, 2015-2017. Amount: $249,914.

15. Co-Investigator for study entitled, “The Gary and Mary West Geriatric Center of Excellence (West COE): Phase II – SED Pre-Launch Operational Implementation”. Funded by the Gary and Mary West Health Institute, 2016. Amount: $261,500.

16. Co-Investigator for study entitled, “The Impact of a Senior Center on Healthcare Utilization”. Funded by the Gary and Mary West Health Institute, 2016. Amount: $49,055.

17. Co-Principle Investigator for study entitled, “Optimizing Communities MPI”. Funded by Academy Health/ONC 2016. Amount: $ 50,000. Grant # 90CL0001-01-00.

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18. Co-Investigator for study entitled, “OSHPD Healthcare Utilization Studies”. Funded by the Gary and Mary West Health Institute, 2016-2017. Amount: $49,728.

19. Co-Principal Investigator for study entitled, “Pre-Hospital SAFR Transitions of Care”. Funded by the State of California, EMSA /ONC, 2016-2017. Amount: $592,000. Grant # C15-046.

20. Co-Principal Investigator for study entitled, “POLST eRegistry”. Funded by California HealthCare Foundation, 2016-2017. Amount: $ 350,075. Grant # 19759.

21. Principal Investigator for study entitled, “Implementation of Telehealth Services in Assisted Living” (STAR). Funded by the Gary and Mary West Health Institute, 2016-2018. Amount: $2,616,445.07

22. Principal Investigator for study entitled, “Beach CCR Sandbox Project”. Funded by the California Department of Public Health, Chronic Disease Surveillance and Research Branch, 2016-2017. Amount: $84,397.

23. Co-Investigator for study entitled, “The Gary and Mary West Senior Emergency Department (West SED): Phase III Existing Space SECU Implementation". Funded by the Gary and Mary West Health Institute, 2017-2018. Amount: $2,405,585.

24. Co-Investigator for study entitled, “Building the Geriatric Emergency care Applied Research (GEAR) network.” This proposal will leverage a early network of hospitals and health care systems committed to implementing quality geriatric emergency care initiatives and build the Geriatric Emergency care Applied Research (GEAR) infrastructure. GEAR will create and support opportunities for multicenter studies and future grant proposals. National Institute on Aging/NIH/DHHS R21AG058926-01, 08/15/18– 07/31/19. Amount: $463,287.

PUBLICATIONS:

Articles:

1. Eduardo Marvez-Valls, Debra Houry, Amy Ernst, Steven Weiss, James Killeen. Protocol for rapid sequence intubation in pediatric patients – a four-year study. Medical Science Monitor 2002; 8(4):229-34.

2. Chan TC, Killeen J, Griswold W, Lenert L. Informatics technology and emergency medical care during disasters. Acad Emerg Med 2004; 11(11):1229-1236.

3. Chan TC, Killeen JP, Kelly D, Guss DA. Impact of rapid entry and accelerated care at triage on reducing Emergency Department Patient wait times, lengths of stay, and rate of left without being seen. Annals of Emergency Medicine, 2005 (46)6: 491-497.

-6- Curriculum Vitae James P. Killeen, MD

4. Killeen JP, Chan TC, Buono C, Griswold WG, Lenert LA. A wireless first responder handheld device for rapid triage, patient assessment and documentation during mass casualty incidents. AMIA Annual Symposium Proc. 2006:429-33

5. Chan TC, Buono CJ, Killeen JP, Griswold WG, Huang R, Lenert L. Tablet computing for disaster scene managers. AMIA Annual Symposium Proc. 2006:875

6. Buono C, Huang R, Brown S, Chan TC, Killeen J, Lenert L. Role-tailored software systems for coordinating care at disaster sites: enhancing collaboration between the base hospitals with the field. AMIA Annual Symposium Proc. 2006:867

7. Firestone D, Wos A, Killeen JP, Chan TC, Guluma K, Davis DP, Vilke GM. Can Urine Dipstick be Used as a Surrogate for Serum Creatinine in Emergency Department Patients Who Undergo Contrast Studies? Journal of Emergency Medicine, 2007 Aug: 33 (2): 119- 122.

8. Buono CJ, Chan TC, Killeen J, Huang R, Brown S, Liu F, Palmer D, Griswold W, Lenert L. Comparison of the effectiveness of wireless electronic tracking devices versus traditional paper systems to track victims in a large scale disaster. AMIA Annu Symp Proc. 2007 Oct 11:886.

9. Guss DA, Chan TC, Killeen JP: The impact of a pneumatic tube and computerized physician order management on lab turnaround time. Ann Emerg Med 2008; 51(2):181-185.

10. Chan TC, Killeen JP, Castillo EM, Vilke GM, Guss DA, Feinberg R, Friedman L. Impact of an Internet-Based Emergency Department Appointment System to Access Primary Care at Safety Net Community Clinics. Ann Emerg Med. 2009 Aug;54(2):279-84. Epub 2008 Dec 13.

11. Chan TC, Killeen JP, Castillo EM, Vilke GM, Guss DA, Feinberg R, Friedman L. Impact of an Internet-Based Emergency Department Appointment System to Access Primary Care at Safety Net Community Clinics. Ann Emerg Med. 2009 Aug;54(2):279-84.

12. Eitel DR, Rudkin SE, Malvehy MA, Killeen JP, Pines JM: Improving Service Quality by Understanding Emergency Department Flow: A White Paper and Position Statement Prepared For the American Academy of Emergency Medicine. The Journal of Emergency Medicine, 2010 Jan: 38 (1): 70-79.

13. Buckley BJ, Castillo EM, Killeen JP, Guss DA, Chan TC. Impact of an Express Admit Unit on Emergency Department Length of Stay. Journal of Emergency Medicine 2010 Nov:39 (5): 669-673.

14. Theodore C. Chan, James P. Killeen, Gary M. Vilke, Jean B. Marshall and Edward M. Castillo. Effect of Mandated Nurse–Patient Ratios on Patient Wait Time and Care Time in the Emergency Department. The Journal of Emergency Medicine, 2010 May: 17 (5): 545– 552.

-7- Curriculum Vitae James P. Killeen, MD

15. Chan TC, Griswold WG, Buono C, Kirsh D, Lyon J, Killeen JP, Castillo EM, Lenert L. Impact of Wireless Electronic Medical Record System on the Quality of Patient Documentation by Emergency Field Responders during a Disaster Mass-Casualty Exercise. Prehosp Disaster Med. 2011 Jul-Aug;26(4):268-75. doi: 10.1017/S1049023X11006480. Epub 2011 Oct 13.

16. Chan TC, Griswold WG, Killeen JP. Author reply. Prehosp Disaster Med. 2013 Dec;28(6):647.

17. Castillo EM, Brennan JJ, Killeen JP, Chan TC. Identifying Frequent Users of Emergency Department Resources. J Emerg Med 2014;47(3):343-7.

18. Brennan JJ, Chan TC, Killeen JP, Castillo EM. Inpatient Readmissions and Emergency Department Visits within 30 Days of a Hospital Admission. West J Emerg Med. 2015;16(7):1025-9.

19. Crowley C, Stuck AR, Martinez T, Wittgrove AC, Zeng F, Brennan JJ, Chan TC, Killeen JP, Castillo EM. Survey and Chart Review to Estimate Medicare Cost Savings for Home Health as an Alternative to Hospital Admission Following Emergency Department Treatment. J Emerg Med. 2016 Dec;51(6):643-647.

20. Stuck AR, Crowley C, Killeen J, Castillo EM. National Survey of Emergency Physicians Concerning Home-Based Care Options as Alternatives to Emergency Department-Based Hospital Admissions. J Emerg Med. 2017 Nov;53(5):623-628.e2. doi: 10.1016/j.jemermed.2017.05.036. Epub 2017 Sep 20.

21. Dameff CJ, Selzer JA, Fisher J, Killeen JP, Tully JL. Clinical Cybersecurity Training Through Novel High Fidelity Simulations. J Emerg Med. 2018 Dec 12. pii: S0736- 4679(18)31055-2. doi: 10.1016/j.jemermed.2018.10.029. [Epub ahead of print].

Book Chapters:

1. Killeen JP: Retrograde Intubation (Chapter 1: Airway). In: Atlas of Emergency Procedures. Rosen P, Chan TC, Vilke GM, Sternbach G (Eds.); St. Louis: Mosby, Inc., 2001, pp 10-11.

2. Killeen JP: Digital Intubation (Chapter 1: Airway). In: Atlas of Emergency Procedures. Rosen P, Chan TC, Vilke GM, Sternbach G (Eds.); St. Louis: Mosby, Inc., 2001, pp 12-13.

3. Killeen JP: Endotracheal Intubation Using a Lighted Stylet (Chapter 1: Airway). In: Atlas of Emergency Procedures. Rosen P, Chan TC, Vilke GM, Sternbach G (Eds.); St. Louis: Mosby, Inc., 2001, pp 14-15.

4. Killeen J: Tendinitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (second edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2003, pp 1110-1.

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5. Killeen J: Tenosynovitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (second edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2003, pp 1114-5.

6. Killeen J: Tendinitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (third edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005, pp 1104-5.

7. Killeen J: Tenosynovitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (third edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005, pp 1106-7.

8. Killeen J: Tendonitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fourth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2011, pp 1106-7.

9. Killeen J: Tenosynovitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fourth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2001, pp 1108-09.

10. Killeen J: Tendonitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fifth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2013, pp 1116-17.

11. Killeen J: Tenosynovitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fifth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2013, pp 1118-19.

12. Killeen J, Dameff C, Dirksen B: Tendonitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fifth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2018.

13. Killeen J, Dameff C, Dirksen B: Tenosynovitis. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (fifth edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2018.

Abstracts:

1. Marvez-Valls EJ, Houry D, Martinez J, Preston C, Killeen J, Kochinski J, Guidry B: Effectiveness of rapid sequence intubation using protocols. Ann Emerg Med 1998;32(3):S52.

-9- Curriculum Vitae James P. Killeen, MD

2. Marvez-Valls EJ, Killeen JP, Martinez J, Preston C, Kochinski J: Complications and deviations from protocol based rapid sequence intubation. Acad Emerg Med 1998;6(5):516-517.

3. Killeen JP, Chan, TC, Hutches D, Smith M, Lenart L. Prehospital field evaluation utilizing 1x-EVDO wireless internet. Second Mediterranean Emergency Medicine Congress. Sitges Spain, September 13-17, 2003. p198.

4. Chan TC, Killeen JP, Kelly D, Vilke GM, Guss DA: Impact of a Rapid Emergency Department Entry and an Accelerated Care Initiative on Patient Wait Times and Length of Stay. Acad Emerg Med 2004;11(5):485.

5. Killeen JP, Chan TC, Guss, DA. Impact of Bar Coding Technology and Computerized Physician Order Entry on Reducing Laboratory Specimen Misidentification Errors in the Emergency Department. Acad Emerg Med 2005;12(5):49.

6. Bush J, Chan TC, Killeen JP, Vilke GM. The Effect of Changing From a Latex Agglutination D-Dimer to an ELISA D-Dimer on Emergency Physicians Ordering Imaging Studies Practices to Evaluate for Pulmonary Embolism. Acad Emerg Med 2005;12(5):41.

7. Chan TC, Killeen JP, Kelly DL, Vilke GM, Guss DA. Accelerated care at triage: Physician-directed ancillary testing at triange for patients waiting in an emergency department. Ann Emerg Med 2005;46(3):S107-S108.

8. Lenert LA, Chan TC, Griswold WG, Killeen J, Krisch D, Mishra R, Palmer DA, Rao RA. Wireless internet information systems for medical response in disasters (WIISARD). AMIA Annu Symp Proc 2006: 1192.

9. Chan TC, Buono CJ, Killeen JP Griswold WG, Huang R, Lenert L. Tablet Computing for Disaster Scene Managers. AMIA Annu Symp Proc. 2006; 2006: 875.

10. Buono C, Huang R, Brown S, Chan TC, Killeen J, Lenert L. Role-tailored software systems for coordinating care at disaster sites: enhancing collaboration between the base hospitals with the field. AMIA Annu Symp Proc 2006: 867.

11. Chan TC, James JP, Kelly D, Guss D. Impact of Rapid Entry and Accelerated Care at Triage on Reducing Emergency Department Patient Wait Times, Length of Stay, and Rate of Leaving Without Being Seen. Annals of Emerg Med, March 2006; 47(3):295.

12. Guss D, Chan T, Killeen J. The Impact of Pneumatic Tube Specimen Transport and Computerized Order Entry on Laboratory Turnaround. Acad Emerg Med, May 2006; 13(5):S63-64.

13. Killeen J, Chan T, Guss D. The Impact of a Pneumatic Tube and Computerized Physician Order Entry on Laboratory Turnaround for Cardiac Markers. SAEM Annual Meeting Abstracts, 2006; S114.

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14. Chan TC, Killeen JP, Castillo EM, Guss DA. The impact of delayed admissions held in the emergency department on wait time, patient care time, and length of stay for other patients. Ann Emerg Med 2006; 48(4 Supp 1):S5.

15. Venieris PY, Chan TC, Killeen J. Multicenter trial assessing the impact of an overnight international “nighthawk” teleradiology system on CT radiology re-interpretation rates. Ann Emerg Med 2006; 48(4 Supp 1):S16.

16. Killeen JP, Chan TC, Vilke GM, Buono C, Griswold W, Rao R, Lenert L. Wireless computerized rapid triage in the field: How well does technology perform during mass casualty incidents and disaster events? Ann Emerg Med 2006; 48(4 Supp 1):S69.

17. Buono C, Lyon J, Huang R, Brown S, Liu F, Vilke G, Killeen J, Chan T, Kirsh D, Lenert L. Does wireless technology improve patient tracking in mass casualty incidents? Acad Emerg Med 2007; 14(5 Suppl 1): S190.

18. Chan TC, Killeen JP, Castillo EM, Vilke GM, Guss DA. Impact of electronic medication reconciliation on triage times for patients seen in the emergency department. Ann Emerg Med 2007; 50(3 Suppl 1):S71.

19. DeMott MC, Killeen J, Schneir AB. Etiologies of extreme hyperpyrexia in an adult emergency department population. J Toxicol Clin Toxicol 2007;459(6):611

20. Vilke G, Chan T, Killen J, Castillo E. Impact of psychiatric patient holds on the emergency department overcrowding. Acad Emerg Med 2008; 15(5 Suppl 1):S221.

21. Buono C, Lyon J, Chan T, Griswold W, Castillo E, Killeen J, Kirsh D, Lenert L. Does using a wireless, electronic patient data collection system increase patient time on the field? Acad Emerg Med 2008; 15(5 Suppl 1):S12.

22. Chan T, Killeen J, Castillo E, Vilke G, Kennedy S, Feinberg R, Guss D. Impact of an internet-based referral appointment system community clinic access and follow-up for ED patients with no primary care. Acad Emerg Med 2008; 15(5 Suppl 1):S104.

23. Vilke G, Chan T, Killeen J, Castillo E. Impact of psychiatric patient holds in the Emergency Department on overcrowding. Acad Emerg Med 2008;15(Supp 1):S221.

24. Kene MV, Jacoby IJ, Davis DP, Killeen JP. Evaluating the Impact of the 2003 San Diego Wildfires on Emergency Department Use. Ann Emerg Med. 2008 Sept 51 (4) 525-526.

25. Vilke GM, Killeen JP, Chan TC, Crumpacker J, Castillo EM. Risk Factors and Characteristics of Falls Among Emergency Department Elderly Patients. Ann Emerg Med. 2008 Sept 52 (4) S160.

26. Chan TC, Killeen JP, Vilke GM, Guss DA, Jones K, Marshall J, Moore T, Castillo EM. Impact of Mandated Nurse-Patient Ratios on Emergency Department Crowding. Ann Emerg Med. 2008 Sept 52 (4) S44.

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27. Killeen D, Killeen J, Castillo E, Chan T, Vilke G. Emergency department patient evaluation of internet and email access for healthcare information. Ann Emerg Med. 2009 April 16 (4) S324.

28. Chan TC, Castillo EM, Vilke GM, Killeen JP. Impact of Mandated Nurse-Patient Ratios on Time to Antibiotic Administration in the Emergency Department. Ann Emerg Med. 2009 Sept 54 (3) S97.

29. Vilke GM, Robertson NB, Castillo EM, Killeen JP. Erythrocyte Sedimentation Rate Compared to C-Reactive Protein as a Screening Marker of Inflammation in the Emergency Department. Ann Emerg Med. 2009 Sept 54 (3) S120-121.

30. Buckley BJ, Castillo EM, Killeen JP, Guss DA, Chan TC. Impact of an express admit unit on emergency department length of stay. J Emerg Med. 2010 Nov;39(5):669-73. Epub 2009 Feb 23.

31. Chan TC, Killeen JP, Vilke GM, Marshall JB, Castillo EM. Effect of mandated nurse-patient ratios on patient wait time and care time in the emergency department. Acad Emerg Med. 2010 May;17(5):545-52.

32. Killeen JP, Castillo EM, Vilke GM, Marshall JB. Impact of Mandated Nurse-Patient Ratios on Emergency Department Discharge Time. Ann Emerg Med. 2010 Sept 56 (3) S61.

33. Chan TC, Castillo EM, Vilke GM, Killeen JP. Do Computerized Medication Alerts Change Medication Orders In the Emergency Department. Ann Emerg Med. 2010 Sept 56 (3) S120- 121.

34. Chan TC, Castillo EM, Humber DM, Killeen JP. Frequency of Pharmacy Interventions and Emergency Overrides Following Implementation of Electronic Pharmacy Review In the Emergency Department. Ann Emerg Med. 2010 Sept 56 (3) S112.

35. Castillo EM, Chan TC, Vilke GM, Prabhakar N, Killeen JP, Luu B. Impact of alcohol and substance use on subject and deputy injury during use of force events. American Public Health Association 138th Annual Meeting, Denver, CO; November 2010.

36. Castillo EM, Chan TC, Killeen JP, Chang W, Chia L, Vilke GM. Alternative and complementary health practices among Emergency Department patients. American Public Health Association 138th Annual Meeting, Denver, CO; November 2010.

37. Castillo EM, Chan TC, Killeen JP, Vilke GM. Effect of the H1N1 Outbreak on Emergency Department Rapid Flu Testing. Acad Emerg Med 2010; 17(Supp 1):S58-S59.

38. Chan TC, Killeen JP, Castillo EM, Lee J. San Diego Safety Net Health Information Exchange. Ann Emerg Med 2011; 58(4s):S310.

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39. Castillo EM, Killeen JP, Rafie S, Humber DM, Chan TC. Emergency Department Care Provider Perception of Department-Based Pharmacist Services. Ann Emerg Med 2011; 58(4s):S328-S329.

40. G.M. Vilke, J.J. Brennan, E.M. Castillo, J.P. Killeen, T.C. Chan. Multiple Hospital Emergency Department Visits Among Frequent Users With a Pain-Associated Discharge Diagnosis. Annals of Emergency Medicine, Vol. 60, Issue 4, S54. Published in issue: October 2012.

41. E.M. Castillo, T.C. Chan, J.P. Killeen, G.M. Vilke. Knowledge of Acute Myocardial Infarction Symptoms: Do Sex Differences Still Exist? Annals of Emergency Medicine, Vol. 60, Issue 4, S83. Published in issue: October 2012.

42. T.C. Chan, E.M. Castillo, J.V. Dunford, R. Fisher, A.M. Jensen, G.M. Vilke, J.P. Killeen. Hot Spots and Frequent Fliers: Identifying High Users of Emergency Medical Services. Annals of Emergency Medicine, Vol. 60, Issue 4, S83–S84. Published in issue: October 2012.

43. J.J. Brennan, T.C. Chan, G.M. Vilke, J.P. Killeen, E.M. Castillo. Identification of Frequent Users of Hospital Emergency Department Resources Using a Community-wide Approach. Annals of Emergency Medicine, Vol. 60, Issue 4, S102. Published in issue: October 2012.

44. T.C. Chan, J.P. Killeen, J.J. Brennan, G.M. Vilke, E.M. Castillo. The Forgotten Emergency Department Visit When Assessing Hospital Readmissions. Annals of Emergency Medicine, Vol. 60, Issue 4, S105. Published in issue: October 2012.

45. J.P. Killeen, G.M. Vilke, J.V. Dunford, R. Fisher, J. Pringle, E.M. Castillo, T.C. Chan. Impact of 12-lead ECG Wireless Transmission on Hospital STEMI Activations. Annals of Emergency Medicine, Vol. 60, Issue 4, S25. Published in issue: October 2012.

46. E.M. Castillo, J.J. Brennan, T.C. Chan, J.P. Killeen, G.M. Vilke. Factors Associated With Frequent Users of Emergency Department Resources. Annals of Emergency Medicine, Vol. 60, Issue 4, S32. Published in issue: October 2012.

47. J.J. Brennan, T.C. Chan, J.P. Killeen, E.M. Castillo, G.M. Vilke. Multiple Hospital Emergency Department Visits Among “Frequent Flyer” Patients With a Psychiatric- Associated Discharge Diagnosis. Annals of Emergency Medicine, Vol. 60, Issue 4, S146– S147. Published in issue: October 2012.

48. Castillo EM, Vilke GM, Killeen JP, Brennan JJ, Chan TC. Visit Urgency between Frequent Emergency Department Users in a Large Metropolitan Region Network. Acad Emerg Med 2012; 19 (Supp 1): S176.

49. Killeen J, Castillo E, Chan T, Vilke G. Emergency Department Patients on Warfarin – How Often is the Visit Due to the Medication? Acad Emerg Med 2012; 19 (Supp 1): S121.

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50. Killeen JP, Chan TC, Vilke GM, Rafie S, Dunlay R, Castillo EM. Does Pharmacist Review of Medication Orders Delay Medication Administration in the Emergency Department? Acad Emerg Med 2012; 19 (Supp 1): S166.

51. Killeen J, Vilke G, Chan T, Oyama L, Carey M, Castillo M. Does the Residency Selection Cycle Impact What Information is Accessed on the Web? Acad Emerg Med 2012; 19 (Supp 1): S202.

52. Castillo EM, Chan TC, Brennan JJ, Killeen JP, Vilke GM. Multiple Hospital Emergency Department Visits Among ‘‘Frequent Flyer’’ Patients with a Pain Associated-discharge Diagnosis. Acad Emerg Med 2012; 19 (Supp 1): S321.

53. Castillo EM, Chan TC, Vilke GM, Killeen JP, Brennan JJ. Factors Associated with Super Users of Emergency Department Resources Admitted to Acute Care. Acad Emerg Med 2013; 20(Supp 1): S183.

54. Brennan JJ, Chan TC, Vilke GM, Castillo EM, Killeen JP. Comorbidity among Frequent Emergency Department Users with Psychiatric Associated Discharge Diagnoses. Acad Emerg Med 2013; 20(Supp 1): S229.

55. Brennan JJ, Castillo EM, Vilke GM, Killeen JP, Chan TC. Factors Associated with Frequent Users of California Emergency Department Resources. Acad Emerg Med 2013; 20(Supp 1): S230.

56. Chan TC, Brennan JJ, Killeen JP, Stevenson ME, Kuntz KE, Vilke GM, Castillo EM. Impact of Social Services Case Management on Homeless, Frequent Users of Emergency Departments. Acad Emerg Med 2013; 20(Supp 1): S231.

57. Brennan JJ, Castillo EM, Wilson M, Chan TC, Killeen JP, Vilke GM. Psychiatric-Associated Visits to California Emergency Departments: Presence of Licensed Psychiatric Beds and Admission. Ann Emerg Med 2013, 62(4), S118.

58. Castillo EM, Brennan JJ, Hsia RY, Killeen JP, Vilke GM, Chan TC. Thirty-day Readmissions Through The Emergency Department In A Large, Metropolitan Region. Acad Emerg Med 2014; 21(Supp 1): S108.

59. Castillo EM, Chan TC, Hsia RY, Killeen JP, Vilke GM, Brennan JJ. Should Rural Hospitals be Concerned about Frequent Users of Emergency Department Resources? Acad Emerg Med 2014; 21(Supp 1): S218.

60. Brennan JJ, Chan TC, Vilke GM, Hsia RY, Killeen JP, Castillo EM. Traveling Super Users of California Emergency Departments. Acad Emerg Med 2014; 21(Supp 1): S220.

61. Killeen JP, Castillo EM, Brennan JJ, Vilke GM, Chan TC. Does Emergency Department Interrogation Reduce ED Time for Patients with Pacemakers or ICDs? Acad Emerg Med 2014; 21(Supp 1): S274.

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62. Castillo EM, Brennan JJ, Hsia RY, Killeen JP, Vilke GM, Chan TC. Multiple Emergency Department Use and 30-day ED Visits. Acad Emerg Med 2014; 21(Supp 1): S322.

63. Chan TC, Killeen JP, Vilke GM, Castillo EM. Impact of the Affordable Care Act on the Health Care Coverage of Patients Seen in the Emergency Department: Initial First Quarter Findings. Ann Emerg Med 2014; 64(4s):S84 –S85.Smith C, Hopper AB,

64. Brennan JJ, Chan TC, Hsia RY, Vilke GM, Killeen JP, Castillo EM. Predicting Frequent Use of Emergency Department Resources. Ann Emerg Med 2014; 64(4s):S118 – S119.

65. Killeen JP, Chan TC, Castillo EM, Grisworld WG. Integrating Environmental Data into a Personal Health Record for Asthma Patients. Ann Emerg Med 2015; 66(4s):S101

66. Stuck AR, Brennan J, Crowley C, Killeen J, Martinez T, Wittgrove A, Castillo E. Exploring Perspectives on Home-Based Health Care as an Alternative to Hospital Admission After Emergency Department Treatment. Ann Emerg Med 2015; 66(4s):S68-S69.

67. Brennan JJ, Vilke GM, Hsia RY, Chan TC, Killeen JP, Huang J, Castillo EM. Transient Ischemic Attack “Bouncebacks”: Emergency Department Discharges Who Return as Admissions Within Seven Days. Ann Emerg Med 2015; 66(4s):S112.

68. Crowley C, Brennan J, Stuck AR, Killeen J, Wittgrove A, Martinez T, Castillo E. Exploring Patient Characteristics and Potential Cost Savings for Home Health as an Alternative to Hospital Admission After Emergency Department Treatment. Ann Emerg Med 2015; 66(4s):S88.

69. Brennan JJ, Chan TC, Vilke GM, Killeen JP, Hsia RY, Tehaney K, Castillo EM. Admissions Within Seven Days of an Emergency Department Discharge. Ann Emerg Med 2015; 66(4s):S89.

70. Killeen JP, Chan TC, Castillo EM, Grisworld WG. Integrating Environmental Data into a Personal Health Record for Asthma Patients. Ann Emerg Med 2015; 66(4s):S101.

71. Stuck AR, Brennan J, Crowley C, Killeen J, Martinez T, Wittgrove A, Castillo E. Exploring Perspectives on Home-Based Health Care as an Alternative to Hospital Admission After Emergency Department Treatment. Ann Emerg Med 2015; 66(4s):S68-S69.

72. Chan TC, Brennan JJ, Vilke GM, Hsia RY, Killeen JP, Castillo EM. The Changing Landscape of Emergency Department Visits in California. Acad Emerg Med 2016; 23:S15

73. Castillo EM, Vilke GM, Killeen JP, Hsia RY, Wilson MP, Brennan JJ. ED Utilization Prior to a Suicide and Self-Inflicted Injury Related ED Visit. Acad Emerg Med 2016; 23:S17.

74. Castillo EM, Brennan JJ, Chan TC, Killeen JP, Hsia RY, Vilke GM. ED Utilization 3-Days Prior to a Fall-Related ED Visit Among Elderly Patients. Acad Emerg Med 2016; 23:S139.

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75. Brennan JJ, Vilke GM, Chan TC, Killeen JP, Hsia RY, Castillo EM. ED Revisits Within 3 Days of an ED Discharge Among Elderly Patients. Acad Emerg Med 2016; 23:S169.

76. Vilke GM, Castillo EM, Brennan JJ, Killeen JP. What Happens to Emergency Patients Who Leave Without Being Seen by a Physician? Ann Emerg Med 2016; 68 (4): S33.

77. Castillo EM, Morgan AO, Vilke GM, Killeen JP, Hsia RY, Brennan JJ. Characteristics of Frequent Users of Emergency Departments with Pain-Related Diagnoses. Ann Emerg Med 2016; 68 (4): S56–S57. S85.

78. Brennan JJ, Vilke GM, Killeen JP, Hsia RY, Castillo EM. Trends among Emergency Department Visits for Suicide-Related Diagnoses, 2008-2014. Ann Emerg Med 2016; 68 (4): S85.

79. Tolia VT, Kreshak AK, Stuck AR, Casale MB, Crowley C, Killeen JP, Castillo EM. Initial Results From an Acute Care at Home Program as an Alternative to Admission. Acad Emerg Med 2017; 24:S137-S138.

80. Tolia VT, Chan TC, Killeen JP, Vilke GM, Kreshak AA, Castillo EM. Identification of Unrecognized Delirium in Senior Emergency Department Patients. Ann Emerg Med 2017; 70(4): S105.

81. Brennan J, Vilke GM, Hsia RY, Killeen JP, Castillo EM. Emergency Department Visits Following Hospital Admissions. Acad Emerg Med 2017; 24:S159.

82. Brennan JJ, Chan TC, Vilke GM, Hsia RY, Killeen JK, Castillo EM. Geriatric visits to California Emergency Department from 2008 through 2014. Ann Emerg Med 2017; 70(4): S158-S159.

83. A. Stuck, C. Crowley, V.T. Tolia, A.A. Kreshak, J.P. Killeen, E.M. Castillo, Z. Agha, T. Morita. Initiating and Improving Emergency Department-Based Processes for Acute Care at Home as an Alternative to Admission. Annals of Emergency Medicine, Vol. 70, Issue 4, S4– S5. Published in issue: October 2017.

84. A.A. Kreshak, V.T. Tolia, T.C. Chan, J.P. Killeen, G.M. Vilke, E.M. Castillo. A Four-Year Descriptive Analysis of Geriatric Patient Visits to the Emergency Department. Annals of Emergency Medicine, Vol. 70, Issue 4, S97. Published in issue: October 2017.

85. J.P. Killeen, E.M. Castillo, G.M. Vilke, T.C. Chan, J.K. Dunford, C. Kahn, R. Powell, J. Sparks, and others. Out-of-Hospital to Emergency Department Data Exchange: A SAFR Transition of Care. Annals of Emergency Medicine, Vol. 70, Issue 4, S2. Published in issue: October 2017.

86. J.J. Brennan, T.C. Chan, G.M. Vilke, J.P. Killeen, R.Y. Hsia, E.M. Castillo. Emergency Department Revisits Within Three Days of an Emergency Department Discharge for Urinary Tract Infection Among Geriatric Patients. Annals of Emergency Medicine, Vol. 70, Issue 4, S85. Published in issue: October 2017.

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87. V.T. Tolia, T.C. Chan, A.A. Kreshak, J.P. Killeen, G.M. Vilke, E.M. Castillo. Identification of Unrecognized Delirium in Senior Emergency Department Patients. Annals of Emergency Medicine, Vol. 70, Issue 4, S105. Published in issue: October 2017.

88. A.B. Minns, A.A. Kreshak, V.T. Tolia, J.P. Killeen. The Prevalence of Benzodiazepine Use in a Geriatric Emergency Department Population. Annals of Emergency Medicine, Vol. 70, Issue 4, S85–S86. Published in issue: October 2017.

89. V.T. Tolia, T.C. Chan, A.A. Kreshak, G.M. Vilke, J.P. Killeen, E.M. Castillo. Evaluation of Mobility and Fall Risk Among Seniors Presenting to the Emergency Department. Annals of Emergency Medicine, Vol. 70, Issue 4, S102. Published in issue: October 2017.

90. J.J. Brennan, T.C. Chan, G.M. Vilke, J.P. Killeen, R.Y. Hsia, E.M. Castillo. Geriatric Visits to California Emergency Department from 2008 Through 2014. Annals of Emergency Medicine, Vol. 70, Issue 4, S158–S159. Published in issue: October 2017.

91. Vilke GM, Brennan JJ, Chan TC, Hsia RY, Killeen JP, Castillo EM. Emergency Department Utilization Three Days Prior to a Septicemia Diagnosis among Geriatric Patients. Acad Emerg Med 2018; 70(4): S45.

92. Castillo EM, Vuong CL, Vilke GM, Brennan JJ, Hsia RY, Killeen JP. 30-Day Readmissions among Elderly Patients Discharged with an Acute Myocardial Infraction. Acad Emerg Med 2018; 70(4): S120.

93. A.A. Kreshak, V.M. Tolia, T.C. Chan, J.P. Killeen, E.M. Castillo. Insurance Coverage and Cost of Patients Enrolled in an Acute Care at Home Pilot Project for Emergency Department Patients. Annals of Emergency Medicine, Vol. 72, Issue 4, S27. Published in issue: October 2018.

94. A.A. Kreshak, V.M. Tolia, T.C. Chan, R.A. Powell, J.J. Brennan, J.P. Killeen, E.M. Castillo. The Effect of an Electronic Decision Support Tool on Emergency Department Prescribing of Naloxone. Annals of Emergency Medicine, Vol. 72, Issue 4, S143. Published in issue: October 2018

95. S. Mcglone, R. Dunlay, E. Castillo, V. Tolia, J. Killeen, A. Minns. Meclizine Prescriptions in the Emergency Department and Return Visits in an Elderly Population. Annals of Emergency Medicine, Vol. 72, Issue 4, S122. Published in issue: October 2018.

96. C.J. Coyne, J. Brennan, E.M. Castillo, J. Killeen, T. Chan. Checkpoint Inhibitor Complications in the Emergency Department: Methods to Improve Awareness and Outcomes. Annals of Emergency Medicine, Vol. 72, Issue 4, S79. Published in issue: October 2018.

97. R. Dunlay, E. Shi, E. Castillo, V. Tolia, J. Killeen, A. Minns. Emergency Physician Accuracy in Prescribing Medications to Elderly Patients With Renal Dysfunction. Annals of Emergency Medicine, Vol. 72, Issue 4, S143. Published in issue: October 2018.

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PRESENTATIONS:

Oral Presentations

1. Killeen, JP, Kelly D, Wright D, Guss DA. “WebCHARTS, An Electronic Medical Record, Tracking and Physician ordering system designed for an Academic Emergency Department. (Oral) Second Mediterranean Emergency Medicine Congress. Sitges Spain, September 13- 17, 2003.

2. Killeen J. A Wireless First Responder Handheld Device for Rapid Triage, Patient Assessment and Documentation during Mass Casualty Incidents. AMIA National Conference, Washington D.C. November 15, 2006.

3. Buono C, Lyon J, Chan T, Griswold W, Castillo E, Killeen J, Kirsh D, Lenert L. Does using a wireless, electronic patient data collection system increase patient time on the field? Society for Academic Emergency Medicine Annual Meeting, Washington, DC; May 2008.

4. Chan TC, Killeen JP, Guss DA, Jones K, Marshall J, Moore T, Castillo EM. Impact of mandated nurse-patient ratios on emergency department overcrowding. American College of Emergency Physicians Scientific Assembly, Chicago, IL; October 2008.

5. Castillo E, Vilke G, Killeen J, Guss D, Marshall J, Chan T. Impact of mandated nurse-patient ratios on ED medication delivery. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2009.

6. Castillo EM, Vilke GM, Killeen JP, Brennan JJ, Chan TC. Visit Urgency between Frequent Emergency Department Users in a Large Metropolitan Region Network. Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

7. Killeen J, Castillo E, Chan T, Vilke G. Emergency Department Patients on Warfarin – How Often is the Visit Due to the Medication? Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

8. Killeen JP, Chan TC, Vilke GM, Rafie S, Dunlay R, Castillo EM. Does Pharmacist Review of Medication Orders Delay Medication Administration in the Emergency Department? Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

9. Castillo EM, Chan TC, Brennan JJ, Killeen JP, Vilke GM. Multiple Hospital Emergency Department Visits Among ‘‘Frequent Flyer’’ Patients with a Pain Associated-discharge Diagnosis. Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

10. Brennan JJ, Chan TC, Vilke GM, Castillo EM, Killeen JP. Comorbidity among Frequent Emergency Department Users with Psychiatric Associated Discharge Diagnoses. Society for Academic Emergency Medicine Annual Meeting, Atlanta, GA; May 2013.

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11. Brennan JJ, Castillo EM, Vilke GM, Killeen JP, Chan TC. Factors Associated with Frequent Users of California Emergency Department Resources. Society for Academic Emergency Medicine Annual Meeting, Atlanta, GA; May 2013.

12. Chan TC, Brennan JJ, Killeen JP, Stevenson ME, Kuntz KE, Vilke GM, Castillo EM. Impact of Social Services Case Management on Homeless, Frequent Users of Emergency Departments. Society for Academic Emergency Medicine Annual Meeting, Atlanta, GA; May 2013.

13. Castillo EM, Brennan JJ, Hsia RY, Killeen JP, Vilke GM, Chan TC. Thirty-day Readmissions Through The Emergency Department In A Large, Metropolitan Region. Society for Academic Emergency Medicine Annual Meeting, Dallas, TX; May 2014.

14. Castillo EM, Brennan JJ, Hsia RY, Killeen JP, Vilke GM, Chan TC. Multiple Emergency Department Use and 30-day ED Visits. Society for Academic Emergency Medicine Annual Meeting, Dallas, TX; May 2014.

15. Killeen JP, Rudkin SE, McCullough L, Conant R. EMRs: The Good, The Bad and The Ugly (Didactic Session). Society for Academic Emergency Medicine Annual Meeting, San Diego, CA; May 2015.

16. Brennan JJ, Vilke GM, Chan TC, Killeen JP, Hsia RY, Castillo EM. ED Revisits within 3 Days of an ED Discharge among Elderly Patients. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2016.

17. Chan TC, Brennan JJ, Vilke GM, Hsia RY, Killeen JP, Castillo EM. The Changing Landscape of Emergency Department Visits in California. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2016.

18. Castillo EM, Morgan A, Vilke GM, Killeen JP, Hsia RY, Brennan JJ. Characteristics of Frequent Users of Emergency Departments with Pain Related Diagnoses. American College of Emergency Physicians Scientific Assembly, Las Vegas, NV; May 2016.

19. Castillo E, Ko K, Howard J, Vilke G, Hsia R, Killeen J, Brennan J. The Rate and Patient Characteristics of 7-Day ED Revisits among Senior Patients. Society for Academic Emergency Medicine Annual Meeting, Orlando, FL; May 2017.

20. Brennan JJ, Chan TC, Vilke GM, Killeen JK, Hsia RY, Castillo EM. ED Revisits within 3 Days of an ED Discharge for Urinary Tract Infection among Geriatric Patients. American College of Emergency Physicians Scientific Assembly, Washington, DC; October 2017.

21. Castillo EM, Vuong CL, Vilke GM, Brennan JJ, Hsia RY, Killeen JP. 30-Day Readmissions among Elderly Patients Discharged with an Acute Myocardial Infraction. Society for Academic Emergency Medicine Annual Meeting, Indianapolis, IN; May 2018.

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Poster Presentations

1. “Successful Treatment of Erythromelalgia with Hyperbaric Oxygen” (Poster). Undersea and Hyperbaric Medical Society Annual Meeting, Boston, Massachusetts; June 30, 1999.

2. Killeen JP, Chan TC, Guss, DA. Impact of Bar Coding Technology and Computerized Physician Order Entry on Reducing Laboratory Specimen Misidentification Errors in the Emergency Department. SAEM Annual Meeting, New York, New York, May 2005.

3. Bush J, Chan TC, Killeen JP, Vilke GM. The Effect of Changing From a Latex Agglutination D-Dimer to an ELISA D-Dimer on Emergency Physicians Ordering Imaging Studies Practices to Evaluate for Pulmonary Embolism. SAEM Annual Meeting, New York, New York, May 2005.

4. Killeen J, Chan T, Guss D. The impact of a Pneumatic Tube and Computerized Physician Order Entry on Lab Turnaround for Cardiac Markers. SAEM Annual Meeting San Francisco, California, May 2006.

5. Killeen J, Chan T, Guss D. The Impact of Pneumatic Tube Specimen Transport and Computerized Order Entry on Lab Turnaround. SAEM Annual Meeting San Francisco, California, May 2006.

6. Chan TC, Killeen JP, Castillo EM, Guss DA. The impact of delayed admissions held in the emergency department on wait time, patient care time and length of stay for other patients. American College of Emergency Physicians Scientific Assembly, New Orleans, LA; October 2006.

7. Castillo EM, Killeen J, Guss DA, Jones K, Marshall J, Chan TC. Impact of mandated nurse- patient ratios on patient flow in 2 California Emergency Departments. Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2007.

8. Killeen J, Chan TC, Castillo EM, Jones K, Guss DA. Inpatient nurse staffing to care for ED boarders does not relieve Emergency Department crowding. Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2007.

9. Killeen JP, Chan TC, Castillo EM, Guss DA. Mandated work injury reporting improves with electronic medical record and documentation. American College of Emergency Physicians Scientific Assembly, Seattle, WA; October 2007.

10. Chan TC, Killeen JP, Castillo EM, Vilke GM, Guss DA. Impact of electronic medication reconciliation on triage times for patients seen in the emergency department. American College of Emergency Physicians Scientific Assembly, Seattle, WA; October 2007.

11. Chan T, Killeen J, Castillo E, Vilke G, Kennedy S, Feinberg R, Guss D. Impact of an internet-based referral appointment system community clinic access and follow-up for ED patients with no primary care. Society for Academic Emergency Medicine Annual Meeting, Washington, DC; May 2008.

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12. Vilke G, Chan T, Killeen J, Castillo E. Impact of psychiatric patient holds in the Emergency Department on overcrowding. Society for Academic Emergency Medicine Annual Meeting, Washington, DC; May 2008.

13. Vilke GM, Killeen JP, Chan TC, Crumpacker J, Castillo EM. Risk factors and characteristics of falls among emergency department elderly patients. American College of Emergency Physicians Scientific Assembly, Chicago, IL; October 2008.

14. Killeen D, Killeen J, Castillo E, Chan T, Vilke G. Emergency department patient evaluation of internet and email access for healthcare information. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2009.

15. Castillo E, Vilke G, Killeen J, Guss D, Feinberg R, Freidman L, Chan T. Factors associated with community clinic follow-up from an ED internet-based referral system. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2009.

16. Marmon J, Castillo E, Vilke G, Killeen J, Chan T. The effect of admitting team resident turnover on Emergency Department patient flow. Society for Academic Emergency Medicine Annual Meeting, New Orleans, LA; May 2009.

17. Chan TC, Vilke GM, Killeen JP, Gus DA, Marshall J, Castillo EM. Impact of mandated nurse-patient ratios on time to antibiotic administration in the Emergency Department. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2009.

18. Vilke GM, Robertson NB, Castillo EM, Killeen JP, Chan TC. Erythrocyte sedimentation rate compared to C-reactive protein as a screening marker in the Emergency Department. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2009.

19. Castillo EM, Chan TC, Killeen JP, Vilke GM. Effect of the H1N1 Outbreak on Emergency Department Rapid Flu Testing. Society for Academic Emergency Medicine Annual Meeting, Phoenix, AZ; June 2010.

20. Killeen JP, Castillo EM, Vilke GM, Marshall JB, Chan TC. Impact of mandated nurse- patient ratios on Emergency Department discharge time. American College of Emergency Physicians Scientific Assembly, Las Vegas, NV; September 2010.

21. Chan TC, Castillo EM, Humber DM, Killeen JP. Frequency of pharmacy interventions and emergency overrides following implementation of electronic pharmacy review in the Emergency Department. American College of Emergency Physicians Scientific Assembly, Las Vegas, NV; September 2010.

22. Chan TC, Castillo EM, Vilke GM, Killeen JP. Do computerized medication alerts change medication orders in the Emergency Department. American College of Emergency Physicians Scientific Assembly, Las Vegas, NV; September 2010.

-21- Curriculum Vitae James P. Killeen, MD

23. Castillo EM, Chan TC, Vilke GM, Prabhakar N, Killeen JP, Luu B. Impact of alcohol and substance use on subject and deputy injury during use of force events. American Public Health Association 138th Annual Meeting, Denver, CO; November 2010.

24. Castillo EM, Chan TC, Killeen JP, Chang W, Chia L, Vilke GM. Alternative and complementary health practices among Emergency Department patients. American Public Health Association 138th Annual Meeting, Denver, CO; November 2010.

25. Chan TC, Killeen JP, Castillo EM, Lee J. San Diego Safety Net Health Information Exchange. American College of Emergency Physicians Scientific Assembly, San Francisco, CA; October 2011.

26. Castillo EM, Killeen JP, Rafie S, Humber DM, Chan TC. Emergency Department Care Provider Perception of Department-Based Pharmacist Services. San Francisco, CA; October 2011.

27. Killeen J, Vilke G, Chan T, Oyama L, Carey M, Castillo M. Does the Residency Selection Cycle Impact what Information is accessed on the Web? Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

28. Castillo EM, Vilke GM, Killeen JP, Brennan JJ, Chan TC. Visit Urgency between Frequent Emergency Department Users in a Large Metropolitan Region Network. Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

29. Killeen J, Castillo E, Chan T, Vilke G. Emergency Department Patients on Warfarin – How Often is the Visit Due to the Medication? Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

30. Killeen JP, Chan TC, Vilke GM, Rafie S, Dunlay R, Castillo EM. Does Pharmacist Review of Medication Orders Delay Medication Administration in the Emergency Department? Society for Academic Emergency Medicine Annual Meeting, Chicago, IL; May 2012.

31. Killeen JP, Vilke GM, Dunford JV, Fisher R, Pringle P, Castillo EM, Chan TC. Impact of 12-lead ECG Wireless Transmission on Hospital STEMI Activations. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

32. Castillo EM, Brennan JJ, Chan TC, Killeen JP, Vilke GM Factors Associated With Frequent Users of Emergency Department Resources. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

33. Castillo EM, Chan TC, Killeen JP, Vilke GM. Knowledge of Acute Myocardial Infarction Symptoms: Do Sex Differences Still Exist? American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

34. Chan TC, Castillo EM, Dunford JV, Fisher R, Jensen AM, Vilke GM, Killeen JP. Hot Spots and Frequent Fliers: Identifying High Users of Emergency Medical Services. American

-22- Curriculum Vitae James P. Killeen, MD

College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

35. Vilke GM, Brennan JJ, Castillo EM, Killeen JP, Chan TC. Multiple Hospital Emergency Department Visits Among Frequent Users With a Pain-Associated Discharge Diagnosis. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

36. Brennan JJ, Chan TC, Vilke GM, Killeen JP, Castillo EM. Identification of Frequent Users of Hospital Emergency Department Resources Using a Community-wide Approach. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

37. Chan TC, Killeen JP, Brennan JJ, Vilke GM, Castillo EM. The Forgotten Emergency Department Visit When Assessing Hospital Readmissions. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

38. Brennan JJ, Chan TC, Killeen JP, Castillo EM, Vilke GM. Multiple Hospital Emergency Department Visits Among “Frequent Flyer” Patients With a Psychiatric-Associated Discharge Diagnosis. American College of Emergency Physicians Scientific Assembly, Denver, CO; October 2012.

39. Castillo EM, Chan TC, Vilke GM, Killeen JP, Brennan JJ. Factors Associated with Super Users of Emergency Department Resources Admitted to Acute Care. Society for Academic Emergency Medicine Annual Meeting, Atlanta, GA; May 2013.

40. Brennan JJ, Castillo EM, Wilson M, Chan TC, Killeen JP, Vilke GM. Psychiatric-Associated Visits to California Emergency Departments: Presence of Licensed Psychiatric Beds and Admission. American College of Emergency Physicians Scientific Assembly, Seattle, WA; October 2013.

41. Castillo EM, Chan TC, Hsia RY, Killeen JP, Vilke GM, Brennan JJ. Should Rural Hospitals be Concerned about Frequent Users of Emergency Department Resources? Society for Academic Emergency Medicine Annual Meeting, Dallas, TX; May 2014.

42. Brennan JJ, Chan TC, Vilke GM, Hsia RY, Killeen JP, Castillo EM. Traveling Super Users of California Emergency Departments. Society for Academic Emergency Medicine Annual Meeting, Dallas, TX; May 2014.

43. Killeen JP, Castillo EM, Brennan JJ, Vilke GM, Chan TC. Does Emergency Department Interrogation Reduce ED Time for Patients with Pacemakers or ICDs? Society for Academic Emergency Medicine Annual Meeting, Dallas, TX; May 2014.

44. Castillo EM, Brennan JJ, Hsia RY, Killeen JP, Vilke GM, Chan TC. Multiple Emergency Department Use and 30-day ED Visits. American College of Emergency Physicians Scientific Assembly, Chicago, IL; October 2014.

-23- Curriculum Vitae James P. Killeen, MD

45. Chan TC, Killeen JP, Vilke GM, Castillo EM. Impact of the Affordable Care Act on the Health Care Coverage of Patients Seen in the Emergency Department: Initial First Quarter Findings. American College of Emergency Physicians Scientific Assembly, Chicago, IL; October 2014.

46. Brennan JJ, Chan TC, Hsia RY, Vilke GM, Killeen JP, Castillo EM. Predicting Frequent Use of Emergency Department Resources. American College of Emergency Physicians Scientific Assembly, Chicago, IL; October 2014.

47. Killeen JP, Chan TC, Castillo EM, Grisworld WG. Integrating Environmental Data into a Personal Health Record for Asthma Patients. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2015.

48. Stuck AR, Brennan J, Crowley C, Killeen J, Martinez T, Wittgrove A, Castillo E. Exploring Perspectives on Home-Based Health Care as an Alternative to Hospital Admission After Emergency Department Treatment. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2015.

49. Brennan JJ, Vilke GM, Hsia RY, Chan TC, Killeen JP, Huang J, Castillo EM. Transient Ischemic Attack “Bouncebacks”: Emergency Department Discharges Who Return as Admissions Within Seven Days. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2015.

50. Crowley C, Brennan J, Stuck AR, Killeen J, Wittgrove A, Martinez T, Castillo E. Exploring Patient Characteristics and Potential Cost Savings for Home Health as an Alternative to Hospital Admission After Emergency Department Treatment. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2015.

51. Brennan JJ, Chan TC, Vilke GM, Killeen JP, Hsia RY, Tehaney K, Castillo EM. Admissions Within Seven Days of an Emergency Department Discharge. American College of Emergency Physicians Scientific Assembly, Boston, MA; October 2015.

Invited Speaking Presentations

2. “Promise and Pitfalls: Emergency Department Information Systems” -- Urgent Matters Regional Conferences, Atlanta, Georgia; October 14, 2005.

3. “Promise and Pitfalls: Emergency Department Information Systems” -- Urgent Matters Regional Conferences, Las Vegas, Nevada; October 28, 2005.

4. Killeen J. IQPC Hospitals Best Practice, San Diego Wireless Internet Information System for Medical Response in Disasters (WIISARD). October 15, 2006.

5. Killeen J. 17th Lecture, San Diego IT Innovation in an Academic Emergency Department. November 17, 2006.

-24- Curriculum Vitae James P. Killeen, MD

6. Killeen J. Quality Improvements in an Academic Emergency Department. EMLRC Meeting Orlando, Florida, March 24, 2007.

7. Killeen J. 5th Annual The Security Summit, Secure Information Sharing for Advances in Healthcare Technology, June 16, 2008

8. Killeen J. The San Diego Beacon Community. Eighth Annual Healthcare Unbound Conference & Exhibition, San Diego CA July 2011

9. Killeen J. HIE and EHR Implementation in California. Redwood Med Net, 5th Annual Connecting California to Improve Patient Care in 2011. Santa Rosa CA July 2011.

10. Killeen J. Sharing Patient Care Summaries in California. California HIE Summit. Sacramento CA November 2011

11. Killeen J. Reducing Readmission Rates with Improved Transitions of Care. Optum Insight Webinar September 2012.

12. Killeen JP, Swafford, R, Budilo P, Beighe, W, Moore T. California’s HIE Laboratory. California HIE Stake holders Summit, Sacramento, CA November 2012.

13. Killeen JP. San Diego Beacon Project, Improving San Diegans Health, International Society for Disease Surveillance, San Diego, CA December 2012

14. Killeen JP, Beighe W, Mattison J, Minch D, Jaeger C. Trust between HIE and HIO’s. California HIE Stake holders Summit, Sacramento, CA May 2013.

15. Killeen JP, Chan T, Castillo E. San Diego Beacon Final Report. HHS Office of National Coordination, Beacon Summit. Washington DC May 2013

16. Killeen JP. San Diego Beacon Update. Emergency Medical Services Administrators' Association of California, San Diego, CA May 2013

17. Killeen JP. Federal Interagency Health Leadership Roundtable #2 Pavilion - Defense Health Headquarters. Washington DC August 2013

18. Killeen JP, Castillo E. Proactive Health Security and Surveillance: HAVEFSE Leadership Meeting. San Francisco August 2013

19. Killeen JP. San Diego Emergency Care Summit – San Diego Health Connect Update. San Diego November 2013

20. Killeen JP, Castillo E. HIMSS Interoperability Showcase Personal Health Record – GeoHealth Demonstration. Orlando February 2014

21. Killeen JP HIMSS – ONC Beacon Success Stories Lecture. Orlando February 2014

-25- Curriculum Vitae James P. Killeen, MD

22. Killeen JP Microsoft Public Health Conference – Public Health Hub and the BEACH Orange March 2014

23. Killeen JP. San Diego Physician Assessment and Clinical Education Program (PACE)- Electronic Medical Records Systems and Information Security and Integrity in Healthcare Settings May 2, 2014

24. Killeen JP. Redwood MedNet Annual Conference - Leveraging the Cloud for Innovative Solutions Santa Rosa July 2014

25. Killeen JP. San Diego's 6th Annual Cloud Computing Conference - Leveraging the Cloud for Innovative Solutions November 2014

26. Killeen JP. 5th Annual National Update on Behavioral Emergencies Conference.- Leveraging the Cloud for Innovative Solutions Scottsdale December 2014

27. Killeen JP. AdvaMed National Conference – Innovation Showcase: Chronic Disease Management October 2015.

28. Killeen JP. Molecular Medicine Tri-Con, Bringing Point-of-Care Testing to the Population San Francisco March 6 - 11, 2016

29. Killeen JP. Redwood MedNet Annual Conference – Pre-hospital Care Arriving into Mainstream Care. Santa Rosa July 2016

30. Killeen JP. San Diego Physician Assessment and Clinical Education Program (PACE)- Electronic Medical Records Systems and Information Security and Integrity in Healthcare Settings October 2016

31. Killeen JP. San Diego Physician Assessment and Clinical Education Program (PACE)- Electronic Medical Records Systems and Information Security and Integrity in Healthcare Settings August 2017

32. Killeen JP, Ko K, Moore L. Senior Telehealth for Assisted Living Residents (STAR) Implementation and Outcomes – UC Telehealth Summit September 2018

33. Killeen JP. San Diego Physician Assessment and Clinical Education Program (PACE)- Electronic Medical Records Systems and Information Security and Integrity in Healthcare Settings October 2018

Software:

-26- Curriculum Vitae James P. Killeen, MD

2. 2003-2006, Killeen JP, Liu F, Haung R, Brown S, Griswald W, Chan TC, Lenert L. WIISARD Provider Chart. NLM grant # BAA02-103/VMS.

Patents:

1. United States Patent Application 20100204659. Bochenko; WJ; Chan; TC; DeKalb; SW; Killeen; JP; Palmer; DA; Sohmer; MJ; Vilke; GM. Medication Delivery System. August 12, 2010.

2. United States Patent Application 20100022987. Bochenko; WJ; Chan; TC; DeKalb; SW; Killeen; JP; Palmer; DA; Sohmer; MJ; Vilke; GM. Medication Delivery System. January 28, 2010.

3. United States Patent Application 20100022953. Bochenko; WJ; Chan; TC; DeKalb; SW; Killeen; JP; Palmer; DA; Sohmer; MJ; Vilke; GM. Medication deliver Devices Having Penetrable Sterility Barriers and Alignment Features. January 28, 2010.

-27- CURRICULUM VITAE JEJO DAVID KOOLA, M.D.

OFFICE ADDRESS: 9500 Gilman Dr MC-0881 La Jolla, CA 92093-0881 Phone: 858-246-2563 Fax: 858-246-2329 [email protected]

EDUCATION: 9/13/2013 – 9/13/2016 Postdoctoral Fellowship in Medical Informatics and Quality Improvement, Tennessee Valley Health System, Department of Veterans Affairs, 1301 24th Ave S, Nashville, Tennessee 37212 8/1/2013 – 06/01/2018 Anticipated M.S., Department of Biomedical Informatics, Vanderbilt University, 2525 West End Ave, Suite 1475, Nashville, Tennessee. 37203. Thesis committee: Dr. Michael Matheny, Dr. Brad Malin, Dr. Daniel Fabbri 7/1/2008 – 6/30/2011 Internship and Residency, Department of Medicine, VCU Hospital System (MCV), 1201 E Marshall St, Richmond, VA 23298 8/1/2004 – 5/15/2008 M.D. (2008) Medical University of South Carolina (MUSC), 171 Ashley Ave, Charleston, South Carolina 29425 8/1/1997 – 6/1/2002 Purdue University (no degree), 610 Purdue Mall, West Lafayette, Indiana 47907

BOARD CERTIFICATION: ABIM Certified on 08/06/2012

PROFESSIONAL LICENSURE: 7/13/2012 – 7/31/2020 California License #A122014 3/23/2012 – 6/30/2015 South Carolina License #MD34447 2/17/2012 – 7/28/2014 Washington State License #MD60264643 8/10/2011 – 7/31/2014 Virginia Medical License #0101250440 8/16/2011 – 7/01/2015 New Mexico Medical License #MD2011-0624 1/04/2013 – 2/28/2019 Texas Medical License #P5199 7/11/2013 – 7/31/2018 Tennessee Medical License #50317

ACADEMIC APPOINTMENTS and POSITIONS: 04/1/2018 – Present Co-Director, Department of Biomedical Informatics Summer Internship Program UCSD, 9500 Gilman Dr, MC-0881, La Jolla, CA 92093 10/1/2016 – Present Clinical Assistant Professor in Biomedical Informatics and Hospital Medicine, Department of Medicine UCSD, 9500 Gilman Dr, MC-0881, La Jolla, CA 92093 9/30/2013 – 9/22/2016 Clinical Instructor in Medicine, Department of General Internal Medicine, 1215 21st Ave S, MCE Suite 6000

Jejo Koola, CV Vanderbilt University, Nashville, TN 37232

PROFESSIONAL MEDICAL EXPERIENCE: 10/1/2016 – Present Hospitalist Physician Division of Hospital Medicine, Department of Medicine UCSD Medical Center San Diego, CA 12/1/2013 – 9/13/2016 Hospitalist Physician Division of General Internal Medicine and Public Health 1215 21st Ave S, MCE Suite 6000 Vanderbilt University Nashville, TN 37232 9/13/2013 – 9/13/2016 Attending Physician Department of Internal Medicine TVHS-Nashville, Dept. of Veterans Affairs 1301 24th Ave S Nashville, TN 37212 7/1/2012 – 8/30/2013 Hospitalist Physician Multicare Auburn Medical Center 202 N. Division St Auburn, WA 98001 4/1/2012 – 8/30/2013 Hospitalist Physician Lovelace Heart Hospital 504 Elm St NE Albuquerque, NM 87102 1/1/2012 – 2/28/2012 Hospitalist Physician Southside Community Hospital 800 Oak St Farmville, VA 23901 1/1/2012 – 9/30/2012 Urgent Care Patient First Clinic 5000 Cox Rd. Colonial Heights, VA 23060 9/1/2011 – 12/31/2011 Hospitalist Physician Christus St. Vincent Regional Medical Center 455 St Michaels Dr Santa Fe, NM 87505

OTHER PROFESSIONAL EXPERIENCE: 7/1/2002 – 8/1/2004 Research Specialist Brain Stimulation Laboratory Medical University of South Carolina Charleston, SC

Jejo Koola, CV 12/1/1999 – 6/30/2000 Research Specialist Department of Biophysics, Vanderbilt University Vanderbilt, TN 6/1/1998 – 8/1/1998 Analyst Abbott Laboratories 100 Abbott Park Rd Lake Bluff, IL 60044

MEMBERSHIPS, PROFESSIONAL ORGANIZATIONS: American Medical Association American College of Physicians Society of Hospital Medicine American Medical Informatics Association

PROFESSIONAL APPOINTMENTS: Health IT Subcommittee for the Society of Hospital Medicine (2012-2014)

EDITORIAL EXPERIENCE: 2018 – Present Ad-hoc reviewer for J. of Biomedical Informatics 2018 – Present Ad-hoc reviewer for Scientific Data 2017 – 2017 Invited reviewer for Indian-Israeli Joint Research Cooperation RFA: "Big Data Analytics in Healthcare" 2016 – Present Ad-hoc reviewer for J. of American Medical Informatics Assoc. 2016 – Present Ad-hoc reviewer for International Journal of Medical Informatics 2014 – 2016 American Medical Informatics Association Annual Symposium 2014 – 2016 American Medical Informatics Association Joint Summits

TEACHING EXPERIENCE: Spring, 2018 Course Director MED-262: Current Trends in Biomedical Informatics UCSD School of Medicine, La Jolla, CA Winter, 2018 Assistant Instructor MED-273: Communicating Biomedical Informatics UCSD School of Medicine, La Jolla, CA Winter, 2018 Course Director MED-262: Current Trends in Biomedical Informatics UCSD School of Medicine, La Jolla, CA Winter, 2018 Section Facilitator SOMC-410: From Principles to Practice. Section: Diagnostic and Therapeutic Challenges UCSD School of Medicine, La Jolla, CA Winter, 2017 Section Facilitator SOMC-410: From Principles to Practice. Section: Can We Talk? Difficult Discussions, Tough Situations

Jejo Koola, CV UCSD School of Medicine, La Jolla, CA 2016 – Present Internal Medicine Resident Preceptor UCSD Medical Center, La Jolla, CA 2013 – 2016 Internal Medicine Resident Preceptor Vanderbilt University Medical Center, Nashville, TN

COMMITTEES: 2016 – Present Health IS Inpatient Governance Committee UCSD Health, La Jolla, CA 2016 – Present Admissions Committee, Department of Biomedical Informatics UCSD School of Medicine, La Jolla, CA 2017 – Present Safe Medication Practices Committee UCSD Health, La Jolla, CA 2017 – Present Health IS Clinical Council UCSD Health, La Jolla, CA 2018 – Present Core Curriculum Committee, School of Medicine UCSD, La Jolla, CA

MENTEES: 9/2017 – 12/2017 Research Mentor to Andrea Castro (PhD Candidate, UCSD) 4/2018 – 6/2018 Research Mentor to Sid Ambulkar (Undergraduate, UCSD) 6/2018 – 8/2018 Research Mentor to Mustafa Hussain (PhD Candidate, UC-Irvine) 6/2018 – 8/2018 Research Mentor to Mayara Costa-Figueiredo (PhD Candidate, UC- Irvine) 6/2018 – 8/2018 Research Mentor to Lauren L’Heureux (Undergraduate, UCSD) 6/2018 – 8/2018 Research Mentor to Yaritza Benitez (MS Candidate, SDSU)

AWARDS: May, 2016 Distinguished Poster, DBMI Research Forum 2016 1997 – 2001 Robert C. Byrd Scholar

INVITED TALKS: 2/27/2018 Division of Gastroenterology Grand Rounds: “Machine Learning Methods for Risk Prediction Models in Patients with Cirrhosis” UCSD School of Medicine, La Jolla, CA 12/07/2017 Invited Lecture: “Medical Informatics Overview” CLRE-Data Management and Informatics UCSD School of Medicine, La Jolla, CA 7/18/2017 Invited Speaker: “Prediction of Mortality among Hospitalized Patients with Cirrhosis among a National VHA Cohort” Dept. of Veterans Affairs HSR&D/QUERI National Conference Washington, DC

RESEARCH SUPPORT:

Jejo Koola, CV Diagnosing “Chemo Brain” Using Digital Phenotyping Agency: UCSD School of Medicine Grant Type: Academic Senate Grant PI: Jejo Koola Period: 12/1/2018 – 12/1/2019 Total Funding: 15,000 The overall objective of this project is to develop methods of identifying chemotherapy related cognitive impairment. Up to 70% of patients have reported significant reduction in cognitive function, colloquially termed “chemo brain,” from chemotherapy. Studying these changes can be difficult within the clinical setting due to the resource requirements. We will evaluate the feasibility of using “digital phenotyping,” assessing the interaction between a patient’s health and their technology use, to diagnose chemotherapy related cognitive impairment. We will use multiple data streams from passive/wearable sensors to assess their daily cognitive status.

Assessing Cognitive Status of Patients with Cirrhosis Using Digital Phenotyping Agency: UCSD School of Medicine Grant Type: Academic Senate Grant RS289R-KOOLA PI: Jejo Koola Period: 6/1/2018 – 5/31/2019 Total Funding: 15,000 The overall objective of this project is to develop methods of identifying early hepatic encephalopathy before the patient requires hospitalization. More specifically we will evaluate the feasibility of using “digital phenotyping,” assessing the interaction between a patient’s health and their technology use, to diagnose hepatic encephalopathy. We will use multiple data streams from a FitBit and the patient’s routine interactions with their regular smartphone to assess their daily cognitive status.

Automated Surveillance and Intervention Among Patients with Liver Cirrhosis Agency: VA HSR&D Grant Type: IIR 13-052 (Investigator Initiated Research) Multiple PIs: (Corresponding) Michael Matheny (Nashville), Samuel Ho (San Diego) Co-Investigator: Jejo Koola Period: (projected) 07/2014 – 06/2019 Total Funding: 1,050,000 (Site 400,000) The overall objective of this project is to develop the informatics infrastructure and tools to facilitate improved evidence based quality care delivery to patients with cirrhosis that will impact readmission and mortality rates. More specifically, we will 1) develop and validate near real-time natural language processing (NLP) tools in order to extract information that is relevant for case finding and risk factor modification among these patients, 2) develop and validate a robust family of logistic regression prediction models for readmission and mortality following hospitalization for use in the identification of high risk patients, 3) development of a clinical dashboard with imbedded clinical decision support and patient data visualization tools to support clinical care delivery, and 4) conduct a pre-post clinical pilot to evaluate the efficacy and adoption of the dashboard when used.

Patient-Centered SCAlable National Network for Effectiveness Research (pSCANNER) Phase 2 Agency: PCORI CDRN 1306-04819 Grant Type: Clinical Data Research Network (CDRN) PI: Lucila Ohno-Machado Co-PI: Michael Matheny Co-Investigator: Jejo Koola Period: 10/2015 – 03/2019 Total Funding: 6,250,000 (Site 400,000) The patient-centered SCAlable National Network for Effectiveness Research (pSCANNER) is a clinical data research network (CDRN) that is contributing to PCORI's national patient-centered clinical research network (called PCORnet) to close this gap. pSCANNER integrates data from

Jejo Koola, CV multiple health systems with fully operational electronic health record (EHR) systems. The security, privacy, and confidentiality of identified patient data are maintained using national standards in HIPAA-compliant environments. pSCANNER focuses on three conditions: congestive heart failure, Kawasaki disease, and obesity. Patients, patient advocates, researchers, and clinicians from these conditions participate in every aspect of pSCANNER decision-making and governance. The network covers over 32 million patients from the University of California systems, the National Veteran Health Administration, AltaMed Health Services, QueensCare Family Clinics, and The Children’s Clinic in Los Angeles area, Cedars-Sinai Medical Center, Keck Medicine of University of Southern California, Los Angeles County Department of Health Services, Children’s Hospital Los Angeles, San Mateo Medical Center, University of Colorado Health System, the Scalable Architecture for Federated Translational Inquiries Network (SAFTINet), the Washington Wyoming Alaska Montana Idaho (WWAMI) region Practice and Research Network (WRPN), and Intermountain Healthcare, a large integrated delivery network in Utah and southern Idaho.

PUBLICATIONS: 1. Huh J, Koola J, Contreras A, Castillo AK, Ruiz M, Tedone G, et al. Consumer Health Informatics Adoption among Underserved Populations: Thinking beyond the Digital Divide. Yearb Med Inform. Accepted for publication. 2018. 2. Miller A, Koola JD, Matheny ME, Ducom JH, Slagle JM, Groessl EJ, et al. Application of contextual design methods to inform targeted clinical decision support interventions in subspecialty care environments. International Journal of Medical Informatics. 2018 Sep 1;117:55– 65. PMID: 30032965 3. Koola JD, Davis SE, Al-Nimri O, Parr SK, Fabbri D, Malin BA, Ho SB, Matheny ME. Development of an automated phenotyping algorithm for hepatorenal syndrome. J Biomed Inform. 2018 Apr;80:87-95. doi: 10.1016/j.jbi.2018.03.001. PubMed PMID: 29530803. 4. Herbsman T, Forster L, Molnar C, Dougherty R, Christie D, Koola J, Ramsey D, Morgan PS, Bohning DE, George MS, Nahas Z: Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance. Human Brain Mapping. 2009; 30(7): 2044-2055. 5. Nahas Z, Teneback C, Chae JH, Mu Q, Molnar C, Kozel FA, Walker J, Anderson B, Koola J, Kose S, Lomarev M, Bohning DE, George MS: Serial vagus nerve simulation functional MRI in treatment-resistant depression. Neuropsychopharmacology. 2007; 32: 1649-1660. 6. Hajcak G, Molnar C, George MS, Bolger K, Koola J, Nahas Z: Emotion facilitates action: a transcranial magnetic stimulation study of motor cortex excitability during picture viewing. Psychophysiology. 2007; 44(1): 91-97. 7. Borckardt J, Nahas Z, Koola J, George MS: Estimating resting motor thresholds in transcranial magnetic stimulation research and practice: a computer simulation evaluation of best methods. Journal of ECT. 2006; 22(3): 169 – 175. 8. Mu Q, Nahas Z, Johnson KA, Yamanaka K, Mishory A, Koola J, Hill S, Horner MD, Bohning DE, George MS:Decreased cortical response to verbal working memory following sleep deprivation. Sleep 2005; 28:55-67. 9. Mishory A, Molnar C, Koola J, Stroud Z, Li X, Kozel FA, Myrick H, Nahas Z, George MS: The maximum-likelihood strategy (MLS) for determining TMS motor threshold, using parameter estimation by sequential testing (PEST) is faster than conventional methods, with similar precision. Journal of ECT. 2004; 20:160-165.

BOOK CHAPTERS: 1. With other authors. Methods of administering transcranial magnetic stimulation. In Transcranial

Jejo Koola, CV Magnetic Stimulation in Clinical Psychiatry. Arlington, VA; American Psychiatric Publishing, Inc. 2007. 2. With other authors. Transcranial magnetic stimulation and brain imaging. In Transcranial Magnetic Stimulation in Clinical Psychiatry. Arlington, VA; American Psychiatric Publishing, Inc. 2007.

ABSTRACTS: 1. Koola JD, Cao A, Chen G, Ho SB, Matheny ME. A Machine Learning Model to Predict Readmission for Patients with Cirrhosis. Presented at the AMIA Annual Symposium. November 2017, Washington DC. 2. Koola JD, Chen G, Perkins A, Cao A, Dever J, et al. Algorithm for identification of patients at high risk for cirrhosis from administrative data. Hepatology (Baltimore, Md.) 66(S1). The 68th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2017; 2017 October; Washington, DC, USA. Hoboken, NJ USA: Wiley; c2017. 3. Santiago P, Ducom J, Matheny ME, Koola JD, Groessl EJ, Ho SB. (2017). Cirrhosis related diagnostic codes for health services research. Hepatology (Baltimore, Md.) 63(S1). 68th Annual Meeting of AASLD. Washington, DC, USA. Hoboken, NJ USA: Wiley; c2017. 4. Koola JD, Ho SB, Chen G, Perkins AM, Cao A, et al. Prediction of Mortality among Hospitalized Patients with Cirrhosis among a National Veterans Health Administration Cohort. 2017 ACP Southern California Chapters Regions I, II & III; 2017 September 16; Los Angeles, CA, USA. 5. Koola JD, Cao A, Perkins A, Chen G, Ho SB, et al. Post-Discharge Mortality in a National Cohort of Veterans Affairs Patients with Cirrhosis. Hepatology (Baltimore, Md.) 63(S1). The 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016; 2016 November; Boston, MA, USA. Hoboken, NJ USA: Wiley; c2016. 6. Koola J, Ho SB, Matheny ME. An Electronic Health Record Phenotyping Algorithm for Identifying Patients with Hepatorenal Syndrome. Presented at the AMIA Annual Symposium. November 2016, Chicago, IL. 7. Koola J, Ho S, Matheny M. Building a Phenotyping Model for Hepatorenal Syndrome. Vanderbilt DBMI Research Forums. May 2016, Nashville, TN. 8. Ho SB, Ducom JE, Miller A, Garvin J, Koola JD, et al. Workflow-guided Development of a Clinical Decision Support Tool for Patients with Advanced Liver Disease. Presented at the AMIA Annual Symposium. November 2016, Chicago IL. 9. Koola J, Davis S, Ho S, Matheny M. Using a Multilayer Self-Organizing Map for Risk Prediction in Hepatorenal Syndrome. Presented at AMIA Joint Summits. March 2016, San Francisco, CA. 10. Koola J, Matheny M. Self-Organizing Maps to Improve Risk Prediction in Hepatorenal Syndrome. Presented at the AMIA Joint Summits. March 2015, San Francisco, CA. 11. Koola J, Ho S, Matheny M. A Novel Visualization for Rapid Summarization of Patient History: Application to Cirrhosis. Presenting at AMIA Annual Symposium. November 2015, Washington, D.C. 12. Koola J, Cronin R, Reeves R, Denton J, Ho S, Matheny M. Development of an Automated Cirrhosis-Associated Symptom/Finding Detection Tool. Presented at the AMIA Annual Symposium. November 2014, Washington, DC. 13. Baudenbacher F, Peters NT, Koola J, Holzer JR, Fong LE, Trontelj Z, Wikswo JP: The role of anisotropy in the initiation and propagation of action currents in cardiac tissue. Bulletin of the American Physical Society. 2001; 46(1): 1173.

EXAMPLE CODE PROJECTS:

Jejo Koola, CV Parallel SPM: http://www.sourceforge.net/projects/parallelspm SPM Batch: http://www.sourceforge.net/projects/spm2batch

SUPPLEMENTAL TRAINING: 2008 – present BLS / ACLS

AWARDS, ACTIVITIES AND HONORS: High school Boy Scouts of America, National Honor Society, National Speech and Debate Team College Robert C. Byrd Scholar Residency Member of Resident Steering Committee, Chair of Social Committee Hobbies Essayist, oil painting, hiking, motorcycling

TECHNICAL SKILLS: Medical procedures Intubation, central venous catheterization, pulmonary artery catheterization, arterial catheterization, code management, thoracentesis, paracentesis, arthrocentesis, lumbar puncture. Languages English, French, Malayalam Computer skills Windows, Mac, UNIX, Linux, Matlab, SPM, R, SQL Server, several languages (C, C++, Java, Perl, Python, Shell programming) EMRs Cerner, McKesson, CPRS, EPIC Laboratory skills Chromatography, electrophoresis, immunoblotting

Jejo Koola, CV OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Kuo, Tsung-Ting eRA COMMONS USER NAME (credential, e.g., agency login): tsungtingkuo POSITION TITLE: Assistant Professor of Medicine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE END FIELD OF STUDY (if DATE applicable) MM/YYYY National Cheng Kung University, Tainan, BS 06/2001 Computer Science and Information Taiwan Engineering National Chiao Tung University, Hsinchu, MS 06/2003 Computer and Information Science Taiwan National Taiwan University, Taipei, Taiwan PHD 01/2014 Networking and Multimedia

A. Personal Statement

As digitization of medical data (e.g., electronic healthcare records) has become prevalent, the cross- institutional healthcare data analysis and predictive modeling in a secure, robust, accurate, efficient and privacy-preserving manner come to be extremely crucial to enhance the quality of healthcare and promote the practice of interoperable medicine. My background in blockchain technology, machine learning and natural language processing offer me a unique perspective to tackle these interdisciplinary issues. I have published 12 first-authored papers and 29 co-authored papers in peer-review international journals and conferences. At present, I am an Assistant Professor of Medicine in the University of California San Diego (UCSD) Health Department of Biomedical Informatics (DBMI). Prior to becoming a faculty member, I was a Postdoctoral Scholar in UCSD DBMI and received the UCSD Chancellor’s Outstanding Postdoctoral Scholar Award. Before becoming a member of DBMI, I was a research assistant (RA) in the Institute of Networking and Multimedia (INM) of National Taiwan University (NTU), the 1st ranked university in Taiwan by the QS World University Rankings 2019. My research interest includes machine learning, blockchain technology, and natural language processing. I presented the blockchain-based predictive modeling algorithms in a workshop co-organized by the Office of the National Coordinator for Health Information Technology (ONC) and the National Institute of Standards and Technology (NIST) in 2016, in which our paper was a winner of the ONC Healthcare Blockchain Challenge. I have a highly referenced genomic/healthcare blockchain review paper published in the Journal of the American Medical Informatics Association (JAMIA) in 2017. My blockchain platform comparison review and blockchain-based privacy-preserving machine learning research papers were both accepted by JAMIA in 2018. I believe that my unique background and experience allow me to make significant contributions to biomedical informatics with interdisciplinary knowledge.

a. Kuo TT, Gabriel RA, Ohno-Machado L. Fair Compute Loads Enabled by Blockchain: Sharing Models by Alternating Client and Server Roles. J Am Med Inform Assoc. 2019 March 20;26(5):392-403. PubMed PMID: 30892656; doi: 10.1093/jamia/ocy180. b. Kuo TT, Zavaleta Rojas H, Ohno-Machado L. Comparison of Blockchain Platforms: A Systematic Review and Healthcare Examples. Manuscript accepted by the J Am Med Inform Assoc. 2019 March 25;26(5): 462-478. PubMed PMID: 30907419. doi: 10.1093/jamia/ocy185. c. Kuo TT, Kim HE, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc. 2017 Nov 1;24(6):1211-1220. PubMed PMID: 29016974; PubMed Central PMCID: PMC6080687. d. Kuo TT, Hsu C, Ohno-Machado L. ModelChain: Decentralized Privacy-Preserving Healthcare Predictive Modeling Framework on Private Blockchain Networks. Use of Blockchain for Healthcare and Research Workshop, a NIST/ONC workshop; 2016; c2016. B. Positions and Honors Positions and Employment 2000 - 2001 Research Assistant, Computer Science and Information Engineering (CSIE), National Cheng Kung University (NCKU), Tainan 2001 - 2003 Research Assistant, Computer and Information Science (CIS), National Chao Tung University (NCTU), Hsinchu 2002 - 2003 Research and Development Engineer, CoreTech Knowledge Inc., Hsinchu 2003 - 2003 Research Assistant, Institute of Information Science (IIS), Academia Sinica, Taipei 2003 - 2005 Applications Engineer / Team Leader, National Instruments, Taipei 2005 - 2010 Research and Development Engineer / Co-Founder, T&C Technologies Inc., Taipei 2008 - 2014 Research Assistant, Graduate Institute of Networking and Multimedia (GINM), National Taiwan University (NTU), Taipei 2014 - 2015 Research and Development Engineer, Leezen Co. Ltd, Taipei 2015 - 2019 Postdoctoral Scholar, University of California San Diego (UCSD) Health Department of Biomedical Informatics (DBMI), UCSD, La Jolla, CA 2019 - Present Assistant Professor of Medicine, UCSD Health Department of Biomedical Informatics (DBMI), UCSD, La Jolla, CA

Other Experience and Professional Memberships 2013 - 2013 Co-organizer, International Joint Conference on Natural Language Processing (IJCNLP) 1st SocialNLP Workshop 2014 - 2014 Co-organizer, International Conference on Computational Linguistics (COLING) 2nd SocialNLP Workshop 2018 - 2018 Co-organizer, UCSD DBMI Summer Internship Program, UCSD (5 students) 2018 - 2018 Co-organizer, UCSD DBMI NLM Short Term Trainee Position (STTP) Summer Internship Program, UCSD (4 students) 2018 - 2018 Co-organizer, iDASH Privacy & Security Workshop - Secure Genome Analysis Competition, UCSD (Track 1, 24 registered and 7 completing teams) 2018 - 2018 Member, American Society of Human Genetics (ASHG) 2018 - 2019 Member, American Medical Informatics Association (AMIA)

Honors 2001 Technology Graduate Record Examinations (TGRE) Computer Science Contest 46th Place, Institute of Information & Computing Machinery (IICM) (Top 4.3% in Taiwan) 2001 Graduation Project Contest Outstanding Award, NCKU CSIE 2001 Programming Contest 2nd Place, NCKU CSIE 2002 Presidential Award, NCTU (Consecutive 2 semesters) 2008 Outstanding Study Group Award (Topic: Social Network Mining), NTU 2008 Association for Computing Machinery (ACM) Knowledge Discovery and Data Mining (KDD) Cup Co-Champion (Task: Breast Cancer Identification by Siemens Healthcare USA), ACM Special Interest Group on Knowledge Discovery and Data Mining (SIGKDD) (NTU Team, worldwide top 1 out of around 700 registered participants) 2009 Outstanding Scholarship, CyberLink (Granted $ 1,000 USD) 2009 ACM KDD Cup 3rd Place of Slow Track (Task: Customer Relationship Prediction by Orange Telecom), ACM SIGKDD (NTU Team, worldwide top 3 out of 1,299 registered participants, Granted $ 500 USD) 2010 ACM Special Interest Group on Computer Graphics and Interactive Techniques (SIGGRAPH) Student Research Competition Semi-Finalist, ACM SIGGRAPH 2010 ACM KDD Cup Champion of All-Team and Student-Team (Task: Educational Data Mining by LearnLab PSLC), ACM SIGKDD (NTU Team, worldwide top 1 out of 655 registered participants, Granted $ 8,900 USD) 2011 Outstanding Performance Scholarship, NTU (ACM SIGKDD KDD Cup NTU Team, Granted $ 8,000 USD) 2011 ACM KDD Cup Champion of Track 1 and 2 (Task: Music Recommendation by Yahoo), ACM SIGKDD (NTU Team, worldwide top 1 out of 2,389 registered participants, Granted $ 10,000 USD) 2012 Outstanding Students Conference Travel Grant, Association for Computational Linguistics and Chinese Language Processing (ACLCLP) (Granted $ 600 USD) 2013 ACM KDD Student Travel Award, ACM SIGKDD (First author of KDD conference full paper, Granted $ 1,100 USD) 2013 Outstanding Students Conference Travel Grant, Foundation for the Advancement of Outstanding Scholarship (FAOS) (Granted 2,200 USD) 2014 Best Doctoral Dissertation Award Runner-Up, Taiwan Institute of Electrical and Electronic Engineering (TIEEE) 2014 Merit Paper Award, Conference on Technologies and Applications of Artificial Intelligence (TAAI) 2014 Best Doctoral Dissertation Award Runner-Up, Association for Computational Linguistics and Chinese Language Processing (ACLCLP) (Invited to present on award ceremony in Conference on Computational Linguistics and Speech Processing (ROCLING) 2014, Granted $ 300 USD) 2016 Use of Blockchain in Health IT and Health-related Research Challenge Winner, The Office of the National Coordinator for Health Information Technology (ONC), US Department of Health & Human Services (HHS) (UCSD DBMI Team, Granted $ 3,000 USD) 2018 Chancellor’s Outstanding Postdoctoral Scholar Award, UCSD (Top 2 out of 971 postdoctoral scholars, granted $ 1,000 USD)

C. Contribution to Science

1. Machine learning and blockchain technology for biomedical predictive modeling. During the era of big data, many well-known machine learning methods have been developed and improved by researchers. However, to apply such methods to real-world data (e.g., electronic healthcare records) and solve problem in a timely manner is usually challenging. Therefore, I aimed at dealing with both theoretical and practical issues for machine learning, such as feature engineering, training/optimization, validation/error analysis, and blending/ensemble, to solve complex large-scale real-world data mining problems. I contributed to the machine learning field by proposing novel methods to solving healthcare problems such as breast cancer identification, depression detection, and protein hierarchy tree refinement. Recently, I focused on combining privacy-preserving machine learning methods with distributed databases such as blockchain to increase the security and robustness of the algorithms and protect patient privacy. My proposed machine learning methods have broad influence on healthcare applications. I am a major contributor to propose algorithms and conduct experiments for all abovementioned studies.

2. Clinical and social natural language processing. Mining from the large and unstructured text corpuses to extract useful information is becoming an important research topic. I applied machine learning techniques to solve natural language processing problems. For example, I integrated natural language processing tools (e.g., cTAKES and MetaMap) using multi-label classification algorithms to extract medical concepts from clinical notes. Also, I designed weakly-supervised learning methods to extract information from research articles for the curation of the Catalog of Genome-Wide Association Study (GWAS). I also conducted studies to finding related publications on PubMed/MEDLINE using word embedding techniques, as well as predicting diffusions of novel topic on social networks using topic modeling algorithms. My proposed natural language processing methods enhance the automatic information extraction from biomedical narratives (e.g., clinical notes and publications). I am a key research member for all abovementioned research to design novel methods and experiments.

a. Kuo TT, Rao P, Maehara C, Doan S, Chaparro JD, Day ME, Farcas C, Ohno-Machado L, Hsu CN. Ensembles of NLP Tools for Data Element Extraction from Clinical Notes. AMIA Annu Symp Proc. 2016; 2016:1880-1889. PubMed PMID: 28269947; PubMed Central PMCID: PMC5333200. b. Gabriel RA, Kuo TT, McAuley J, Hsu CN. Identifying and Characterizing Highly Similar Notes in Big Clinical Note Datasets. J Biomed Inform. 2018 Apr 18; PubMed PMID: 29679685. c. Jain S, Tumkur KR, Kuo TT, Bhargava S, Lin G, Hsu CN. Weakly supervised learning of biomedical information extraction from curated data. BMC Bioinformatics. 2016 Jan 11;17 Suppl 1:1. PubMed PMID: 26817711; PubMed Central PMCID: PMC4847485. d. Wei W, Marmor R, Singh S, Wang S, Demner-Fushman D, Kuo TT, Hsu CN, Ohno-Machado L. Finding Related Publications: Extending the Set of Terms Used to Assess Article Similarity. AMIA Jt Summits Transl Sci Proc. 2016; 2016:225-34. PubMed PMID: 27570676; PubMed Central PMCID: PMC5001748.

3. Large-scale network analysis. An important source of information comes from big and complex networks, such as social networks, stakeholder networks, and citation networks. I extended the applications of machine learning algorithms to the analysis of such networks. For example, I devised an unsupervised learning approach using aggregative statistics to predict links on various heterogeneous networks (Foursquare, Twitter, Plurk, and DBLP), while preserving individual’s privacy of personal preference. I also designed a network to analyze the stakeholders from publicly held corporations, a method to rank publications in dynamic citation networks and to predict future citations of publications, and a framework to model/measure/evaluate/visualize/simulate influence propagation using diffusion records and geographic location in microblog platforms. My proposed network analysis and prediction algorithms improve the understanding of complicated and heterogeneous network structures. I am a main contributor for all of the studies.

a. Kuo TT, Yan R, Huang Y, Kung P, Lin S. Unsupervised Link Prediction Using Aggregative Statistics on Heterogeneous Social Networks. 19th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD); 2013; c2013. b. Kuo TT, Hung S, Lin W, Lin S, Peng T, Shih C. Assessing the Quality of Diffusion Models Using Real- World Social Network Data. 2011 International Conference on Technologies and Applications of Artificial Intelligence (TAAI); 2011; c2011. c. Li C, Kuo TT, Ho C, Hong S, Lin W, Lin S. Modeling and evaluating information propagation in a microblogging social network. Social Network Analysis and Mining. 2013; 3(3):341-357. d. Li C, Hsieh H, Kuo TT, Lin S. SocioCrowd: a social-network-based framework for crowd simulation. ACM SIGGRAPH 2010 Posters; 2010; ACM; c2010.

4. Knowledge engineering and intelligent systems. Learning knowledge from human expert is essential for computer to perform tasks in many domains, such as medication safety and network security. As my early research direction, I investigated knowledge engineering algorithms and intelligent systems. For example, I proposed a three-phase (preprocessing, partitioning, and meta-knowledge-construction) knowledge fusion framework which to reconstruct rules and meta-knowledge in rule-based systems and to optimize the structural and the semantic meanings. I also designed a two-layer distributed network intrusion detection system (IDS) to detect complicated network intrusions, developed an analysis preprocessing and rule reordering component to improve the overall performance of IDS, and devised an intelligent shopping comparison agent to automatically analyze, extract and compare price information for consumers. My proposed knowledge engineering methods increase the effectiveness and efficiency of real-world systems. I am a central research member for design and implementation of new methods and systems.

a. Kuo TT, Tseng S, Lin Y. Ontology-Based Knowledge Fusion Framework Using Graph Partitioning. 16th international conference on Developments in applied artificial intelligence; 2003; c2003. b. Lin Y, Tseng S, Kuo TT. Two-Layer Network Intrusion Detection System. International Computer Symposium; 2002; c2002. c. Lin Y, Hsu Y, Wang C, Tseng S, Kuo TT, Lin S, Tsai M. A Study of Highly Portable and Adaptable IDS. Taiwan Area Network Conference (TANET); 2002; c2002. d. Tseng S, Shih C, Hsu T, Kuo TT. Design of an Intelligent Comparison Shopping Agent. Conference on Technologies and Applications of Artificial Intelligence (TAAI); 2001; c2001. D. Additional Information: Research Support and/or Scholastic Performance Ongoing Research Support K99HG009680, NIH Kuo (PI) 08/24/17-06/30/19 PI BECKON - Block Estimate Chain: creating Knowledge ON demand & protecting privacy The proposed research will develop practical methods to support privacy-preserving genomic and healthcare predictive modeling, and build innovations based on blockchain technology for secure and robust machine learning training processes. The development of such privacy technology may increase public trust in research and quality improvement. The technology we propose will also contribute to the sharing of predictive models in ways that meet the needs of genomic research and healthcare. Completed Research Support OT3OD025462, NIH Ohno-Machado (PI) 09/30/17-11/30/18 Co-investigator California: Cloud-agnostic Architecture to Locate Indexed FAIR Objects and safely Reuse them in New Integrated Analyses Designing an architecture, which is cloud-agnostic, to locate indexed FAIR objects and resources, and then reuse them safely in new and integrated processes and analyses.

U24AI117966, NIH Ohno-Machado (PI) 09/01/14-08/23/17 Postdoc bioCADDIE: Biomedical and healthCAre Data Discovery and Indexing Ecosystem Coordinating consortium engaging community for metadata specifications, data discovery index development.

CDRN-1306-04819 Phase 2, PCORI Ohno-Machado (PI) 10/01/15-08/23/17 Postdoc Patient-Centered SCAlable National Network for Effectiveness Research PCORnet clinical data research network based on the implementation of distributed analytics across VINCI (VA national enterprise data warehouse), University of California clinical data warehouses, USC and FQHCs.

CDRN-1306-04819, PCORI Ohno-Machado (PI) 01/01/14-06/30/15 Postdoc Patient-Oriented Scalable National Network for Effectiveness Research PCORnet clinical data research network based on the implementation of distributed analytics across VINCI (VA national enterprise data warehouse), University of California clinical data warehouses, USC and FQHCs.

U01HG006894, NHGRI Hsu (PI) 09/24/12-06/30/16 Postdoc Accelerating Curation of GWAS Catalog by Automatic Text Mining The major goals of this project are to perform automatic text mining of current genetics literature to establish a highly curated catalog of published genome-wide association studies. CHRISTOPHER A. LONGHURST, MD, MS, FACMI

PERSONAL INFORMATION

Office Address 9560 Towne Centre Drive M/C #8935 San Diego, CA 92121

Internet Address [email protected] @calonghurst

Contact Numbers (858) 249-6880 assistant (650) 575-8699 cell

FACULTY AND ADMINISTRATIVE APPOINTMENTS

2015 – current UC San Diego School of Medicine Clinical Professor of Medicine (Biomedical Informatics) and Pediatrics (2015 – current)

UC San Diego Health Sciences Associate Chief Medical Officer for Quality and Informatics (2018 – current) Chief Information Officer (2015 – current)

Stanford University School of Medicine Consulting Faculty, Biomedical Informatics Training Program

2004 – 2015 Stanford Medicine Founding Program Director, Clinical Informatics fellowship (2013-2015) (first ACGME-accredited CI fellowship in the nation)

Stanford University School of Medicine Clinical Professor (2015) of Pediatrics (primary) and Biomedical Informatics (secondary) Clinical Associate Professor (2012 – 2015) of Pediatrics (primary) and Biomedical Informatics (by courtesy) Clinical Assistant Professor (2006 – 2012) of Pediatrics Clinical Instructor, Division of General Pediatrics (2004 – 2006)

Stanford Children’s Health VP of Informatics (2011 – 2015) and Analytics (2012 – 2015) Chief Medical Information Officer (2009 – 2015) Medical Director, Clinical Informatics (2008 – 2010) Physician Lead, Clinical Informatics (2004 – 2008)

2004 – 2008 Santa Clara Valley Medical Center, Department of Pediatrics Part-time NICU Hospitalist, Division of Neonatology

EDUCATION

2002 – 2004 Stanford University Medical Center Pediatric Residency

2001 – 2002 Stanford University Medical Center Pediatric Internship

1996 – 2001 University of California at Davis, School of Medicine M.D., June 2001

University of California at Davis, Graduate Group in Medical Informatics M.S., June 2000

1992 – 1996 University of California at San Diego B.S., Molecular Biology, magna cum laude

1988 – 1992 Jesuit High School Sacramento, CA

LICENSURE & CERTIFICATION

Printed March 31, 2019 Christopher A. Longhurst, MD, MS

LICENSURE & CERTIFICATION

Expires Jan 2024 Diplomate (inaugural), Clinical Informatics, American Board of Preventive Medicine (original certification 2014)

Expires Dec 2023 Diplomate, American Board of Pediatrics (original certification Oct 2004, renewed Oct 2014)

Expires Mar 2017 Controlled Substance Registration (BL7973642), Drug Enforcement Administration (original certification Sept 2002)

Expires Jan 2018 Physician and Surgeon License (A80051), Medical Board of California (original Aug 2002, expires Jan 2020)

Expires Jan 2016 Pediatric Advanced Life Support (PALS) Certification (original certification 2001, last renewed Jan 2014)

PROFESSIONAL MEMBERSHIPS

2014 – current American College of Medical Informatics (ACMI)

2009 – current College of Healthcare Information Management Executives (CHIME)

2005 – current Association of Medical Directors of Information Systems (AMDIS)

1999 – current American Medical Informatics Association (AMIA)

HONORS, AWARDS, & SCHOLARSHIPS

May 2017 San Diego Top Tech Exec award (http://www.toptechexecs.com/2017-top-tech-exec-awards-recap/)

June 2015 AMDIS Award for Excellence, Outstanding Achievement and Special Recognition in Applied Medical Informatics

April 2015 HISTalk Award for “Most Effective Clinical Informatics Professional”

Nov 2014 Elected Fellow, American College of Medical Informatics (http://www.amia.org/programs/acmi-fellowship)

Oct 2014 “25 CMIO’s to Know” – Becker’s Hospital Review (http://www.beckershospitalreview.com/lists/25-cmios-to-know.html)

2012, 2011, 2010 Modern Healthcare magazine “Top 25 Clinical Informaticist” award during the inaugural year (2010) and two subsequent

2015 Stanford University School of Medicine, Office of the Dean Award for Teaching Excellence, Letter of Distinction (2004-2005, 2010-2014) Honor Roll for Teaching (2009-2010, 2014-2015)

2012 2012 Computerworld Honors Laureate in Innovation category (accepted by Natalie Pageler, Chris Longhurst, and Paul Sharek on behalf of Lucile Packard Children's Hospital)

2010 Stanford University School of Medicine 2010 Faculty Fellow

2001 Ernest Gardner Award for Outstanding Student in Neurology

2000, 2001 Theordore Hartzell Medical Scholarship Award

2000, 2001 MacKenzie Foundation Scholarship

Summer 2000 UC Davis School of Medicine Predoctoral Research Fellowship

1997 – 2001 James Foundation Medical Student Scholarship

FORMAL MENTORING (FACULTY, FELLOWS AND GRADUATE STUDENTS)

2015 – current Yumi DiAngi, MD, and Yaniv Kerem, MD (2015 - 2017 Stanford fellows in clinical informatics)

2014 – current Veena Goel, MD and N. Lance Downing, MD (2014 - 2016 Stanford fellows in clinical informatics)

2013 – 2015 Pediatric Clinical Educator (CE) Mentoring Program – mentor for 6 junior faculty members (Arash Anoshiravani, Natalie Pageler, Jonathan Palma, Lindsay Stevens, Rajiv Kumar, Julie Pantaleoni)

Printed March 31, 2019 (Page 2 of 11) Christopher A. Longhurst, MD, MS

FORMAL MENTORING (FACULTY, FELLOWS AND GRADUATE STUDENTS)

2010 – 2015 Advising Faculty, Biomedical Informatics Training Program. Advise and oversee MS and PhD student projects including Sarah Poole (PhD candidate).

2005 – 2015 Rotation Director of Clinical Informatics elective for pediatric residents at Stanford University Medical Center

2012 Michael Tierney, MD – M.S. student in medical informatics at Oregon Health Science University; provided oversight of practicum at Stanford/LPCH

2009 – 2012 Jon Palma, MD – Clinical Fellow in Neonatology at Stanford University School of Medicine with informatics research focus; Scholarly Oversight Committee member

2009 – 2010 Natalie Pageler, MD –Clinical Fellow in Pediatric Critical Care Medicine at Stanford University School of Medicine with informatics research focus; Scholarly Oversight Committee member

TEACHING RESPONSIBILITY

2014-2015 Instructor of Record for Biomedical Informatics 208, Clinical Informatics Literature Review (http://bmi208.stanford.edu)

RESEARCH FUNDING

2012 Hewlett Packard corporate grant – co-principal investigator for $4M grant over 10 years; used in part to fund HP endowed fellows in Clinical Informatics at Stanford University Medical Center

2010 Hewlett Packard corporate grant – principal investigator for $100k grant to introduce automated real-time patient-centered quality/safety dashboards in the EMR at LPCH

2009 LPCH Innovations in Patient Care Grant – helped Dr. Andrew Shin earn $25k in funding for development of real-time automated EMR-based CVICU dashboard.

2009 LPCH Innovations in Patient Care Grant – helped Dr. Scott Sutherland earn $15k in funding for development of renal transplant trigger tool in collaboration with Drs. Paul Sharek, and Steve Alexander

2007 – 2009 Hewlett Packard – LPCH partnership – helped to bring $1.4M in hardware grants over 3 years as well as $500k in research funding in collaboration with Dr. Atul Butte (PI) to investigate supervised machine learning methods applied to clinical data repository

SELECT INVITED PRESENTATIONS, NATIONAL / INTERNATIONAL

Mar 7, 2019 UC San Diego, Grand Rounds in Pediatrics – “Evidence-based Medicine and Physician Burnout in the EMR Era”

Aug 28, 2018 Epic User Group Meeting, Madison, WI – “Clinician Wellness in the EMR Era: International Lessons Learned” Aug 1, 2018 Health Informatics Society of Australia (HISA), Sydney, Australia – “Clinician Burnout in the EMR Era” (plenary) July 29, 2018 Health Informatics Society of Australia (HISA), Sydney, Australia – “Health IT Megatrends and Workforce Implications” July 13, 2018 Health IT Summit Series, Denver, CO – “Clinician Burnout in the EHR Era” April 20, 2018 Hasso Plattner Institute, University of Potsdam, Potsdam, Germany – “Aligning Health IT with Health Megatrends” April 18, 2018 ConHIT Annual Conference, Berlin, Germany – “Aligning Health IT with Health Megatrends” March 30, 2018 Washington University Institute for Informatics (I2) Scientific Symposium, St. Louis, MO – External Advisory Board panel March 26, 2018 HFMA/CAHL Spring Conference, Sacramento, CA – Panel Discussion “C-suite View on Leadership and Change Management” March 1, 2018 OHSU Grand Rounds in Clinical Informatics, Portland, OR – “Evidence-based Medicine in the EMR Era” Feb 3, 2018 ACMI Annual Conference, Scottsdale, Arizona – “Collaborative Informatics Science: Opportunities and Challenges in the AMC”

October 11, 2017 Health Informatics Society of Australia (HISA), Brisbane, Australia – “Health IT Megatrends and High-Value Healthcare” August 10, 2017 Clinical Excellence Research Center (CERC), Stanford University – “Health IT Megatrends and High-Value Healthcare” June 30, 2017 HIMSS 1st Annual Patient Engagement Summit, San Diego, CA – “Connected Health is the next Blockbuster Drug” June 22, 2017 AMDIS Annual Conference, Ojai, CA – Panel presentation on “Evolving Roles and Relationship of the CIO/CMIO” Feb 4, 2017 ACMI Annual Conference, Duck Key, Florida – “Clinical Informatics 2.0 Requires Blurring Academic and Service Roles” Jan 24, 2017 San Diego, Healthcare Informatics Summit – “Evidence-based Medicine in the EMR Era” Jan 12, 2017 UC San Francisco, Grand Rounds in Medicine – “Evidence-based Medicine in the EMR Era”

Oct 18, 2016 UC San Diego, Grand Rounds in Radiology – “Bringing Big Data to the Bedside” Sept 22, 2016 AACC Point of Care Conference, Copenhagen, Denmark – Using Consumer Technology to Integrate Patient Data in the EHR June 20, 2016 CHIME Boot Camp for CMIOs, Ojai, CA – “Building Health IT Teams” May 3, 2016 Stanford University, Grand Rounds in Radiology – “Bringing Big Data to the Bedside”

Printed March 31, 2019 (Page 3 of 11) Christopher A. Longhurst, MD, MS

SELECT INVITED PRESENTATIONS, NATIONAL / INTERNATIONAL

April 18, 2016 Indiana University, Children’s Health Services Symposium, Indianapolis, IN – “Evidence-based Informatics for Child Health” March 7, 2016 NLM Data Forum, Salt Lake City, UT – “Evidence-based Medicine in the EMR Era”

October 16, 2015 Midwest Bioinformatics Conference, Kansas City, MO – Invited Keynote “Bringing Big Data to the Bedside” Sept 2, 2015 Epic User Group Meeting, Madison, WI – EMR-enabled self-service analytics August 19, 2015 MedInfo 2015, Sao Paulo, Brazil – CDS Tutorial July 17, 2015 Jurong Health Services, Singapore – Improving Healthcare Value with the EMR July 16, 2015 Jurong Health Services, Singapore – Transitioning from Implementation to Operations: Lessons at Stanford June 25, 2015 AMDIS Panel, Ojai, CA - Deriving Value from Health IT panel May 27, 2015 Health Technology Forum 2015 Innovation Conference, Burlingame, CA – CMIO panel Mar 22, 2015 Big Data in Biomedicine, Stanford, CA – “Bringing Big Data to the Bedside with the Green Button” Jan 27, 2015 Personalized Medicine World Conference, Mountain View, CA – Panel on “Supporting Precision Medicine with Health IT”

Dec 10, 2014 Kaiser Permanente Northern California Department of Research, Oakland, CA – “Evidence-based Clinical Informatics” Nov 16, 2014 AMIA 2014, Washington DC - panel on “Latest Developments in Informatics Certification and Accreditation Nov 14, 2014 Evidence-based Veterinary Medicine Association (EBVMA) – “Evidence-based Medicine in the EMR Era” Oct 23, 2014 New Children’s Hospital, Dublin, Ireland – “Digitizing Healthcare for Children: The Stanford Children’s Experience” Oct 13, 2014 CHOC Pediatric Innovation Conference – “An Alarming Trend: Data-driven Vital Sign Limits” Oct 12, 2014 AAP Council on Clinical Information Technology – “Switching EMR Systems” Oct 3, 2014 St. Louis Children’s Hospital, St. Louis, MO – “Evidence-based Clinical Informatics” June 9, 2014 AAMC spring conference – plenary keynote with Dr. Natalie Pageler on “Refocusing Medical Education in the EMR Era”

Nov 4, 2013 Singularity University FutureMed conference, San Diego, California – “Shifting to Practice-based Evidence” July 10, 2013 Indiana University School of Medicine, Grand Rounds in the Department of Pediatrics at Riley Children’s Hospital July 9, 2013 New York University Medical Center, Grand Rounds in the Department of Pediatrics April 18, 2013 HISA, Melbourne, Australia – Invited keynote “Using Big Data to Shift from Evidence-based Practice to Practice-based Evidence” April 17, 2013 University of Auckland, School of Public Health, Invited Seminar “Using Big Data to Shift to Practice-based Evidence” Mar 25, 2013 iHT2 conference, San Francisco, CA – “Using Big Data to Shift from Evidence-based Practice to Practice-based Evidence” Feb 5, 2013 Singularity University FutureMed Executive Program, Mountain View, CA – “Digitizing Healthcare: Opportunities and Predictions” Jan 30, 2013 Santa Clara Valley Medical Center, San Jose, CA – Grand Rounds in the Department of Pediatrics with Dr. Natalie Pageler

Nov 6, 2012 AMIA panel session, Chicago, IL – Pediatric Safety Risks from Unintended Consequences of the Use of EMRs Designed for Adults Sept 25, 2012 Mott Children’s Hospital, Ann Arbor, MI – Aileen Sedman Annual Grand Rounds in Pediatric Informatics Sept 13, 2012 Hospital Council Summit of Northern California, San Francisco, CA – “The Packard Children’s Experience” Aug 8, 2012 Royal Children’s Hospital, Melbourne, Australia – “Digitizing Healthcare: The Packard Children’s Experience” Aug 7, 2012 Southern Health, Melbourne, Australia – “Digitizing Healthcare: The Packard Children’s Experience” Aug 7, 2012 Australian Centre for Healthcare Innovation, Melbourne, Australia – “Digitizing Healthcare: The Packard Children’s Experience” Aug 3, 2012 Queensland Health, Brisbane, Australia – “Digitizing Healthcare: The Packard Children’s Experience” Aug 3, 2012 Queensland Children’s Hospital, Brisbane, Australia - “Digitizing Healthcare: The Packard Children’s Experience” Aug 3, 2012 Mater Health Services, Brisbane, Australia – “Digitizing Healthcare: The Packard Children’s Experience” June 27, 2012 AMDIS Annual Conference, Ojai, CA – “Regulating the EMR: Point / Counterpoint” with Dr. David Classen May 7, 2012 Healthcare Informatics Executive Summit, Orlando, FL – “Leveraging the EMR for Patient Safety and Improved Clinical Outcomes” April 28, 2012 American College of Physician Executives annual meeting, San Francisco, CA – “Leading Innovation in Healthcare IT” April 26, 2012 Epic Physician Advisory Council, Madison, WI – “Integrating BiliTool in the EMR” April 19, 2012 Children’s Hospital Association CIO Forum, San Diego, CA – “Agile Analytics in Healthcare” Apr 11, 2012 UC Davis Health Informatics seminar – “Cases Studies in Clinical Decision Support: The Stanford Experience” Feb 20, 2012 HIMSS 2012, Las Vegas, NV – Clinical Decision Support Panel

Oct 26, 2011 AMIA 2011, Washington DC – “Real-time Patient Dashboards Enhance Patient Safety and Quality Improvement” July 13, 2011 AMDIS 20th Annual Conference, Ojai, CA – “Beyond MU: Leveraging the EMR for Clinical Effectiveness” May 12, 2011 Healthcare Informatics Exec Summit, SF, CA – The Challenge of Building High Performing Clinical Informatics Teams May 11, 2011 Singularity University FutureMed Executive Program, Mountain View, CA – “Digitizing Healthcare” May 4, 2011 Salinas Valley Memorial Health System Grand Rounds, Salinas, CA – “Evidence-based EMR Implementation” March 21, 2011 Palo Alto Rotary Club – “Digitizing Healthcare: Successes and Challenges” March 16, 2011 HP 2011 Analyst Summit, San Francisco, CA – “Evidence-based EMR Implementation: The LPCH Case Study” March 10, 2011 NIH Workshop on EHR Research Priorities, Washington D.C. – “EHR Data Harmonization, Standardization, and Quality" February 22, 2011 HIMSS 2011, Orlando, FL – “The New HIT Landscape: Now that you have an EHR—what next?” January 27, 2011 HIMSS Northern California Symposium – “The New HIT Landscape: “Now that you have an EHR—what next?” January 12, 2011 UC Davis Health Informatics symposium – “Evidence-based Clinical Informatics: The Stanford Journey”

July 14, 2010 AMDIS 19th Annual Conference, Ojai, CA – “Evidence-based CPOE Implementation: Achieving Meaningful Outcomes” July 8, 2010 Singularity University, Mountain View, CA – “Future of Medicine: The EMR and PHR” March 9, 2010 Providence Hospital Grand Rounds, Anchorage, AL – “Evidence-based EMR Implementation in Neonatology” March 1, 2010 HIMSS 2010 Physician Session, Atlanta, GA – “Activation Strategies for CPOE and Clinical Documentation” Feb 3, 2010 Child Health Corporation of America (CHCA) annual CEO meeting, Mountain View, CA – “PHR’s at LPCH”

Printed March 31, 2019 (Page 4 of 11) Christopher A. Longhurst, MD, MS

SELECT INVITED PRESENTATIONS, NATIONAL / INTERNATIONAL

Nov 6, 2009 Lucile Packard Children’s Hospital Grand Rounds – “Promises and Challenges of Healthcare IT Locally and Nationally” Nov 3, 2009 13th Annual Healthcare Internet Conference, Las Vegas, NV – “Evidence-based PHR Implementation” Oct 26, 2009 Child Health Corporation of America (CHCA) annual CIO/CMIO meeting – “Implementing an Untethered PHR at LPCH” Oct 5, 2009 Cerner Health Conference 2009 mini-keynote – “Optimization of the EMR using Web Technology” July 22, 2009 Singularity University, Mountain View, CA – “Future of Medicine: The EMR and PHR” June 2, 2009 O’Connor Hospital Grand Rounds, San Jose, CA – “Avoiding Unintended Consequences of Health IT Implementations” April 26, 2009 Tawam Hospital, Al Ain, United Arab Emirates – “Driving Quality Improvement with the EMR” April 25, 2009 Al Corniche Women’s Hospital , Abu Dhabi, United Arab Emirates – “EMR Implementation in Neonatology/Obstetrics” March 4, 2009 HP Health & Life Sciences Symposium, Phoenix, AZ – “Driving Quality Improvement with CPOE” Jan 16, 2009 HIMSS Colorado Chapter Annual Meeting Keynote Address, Denver, CO – “An Evidence-based CPOE Implementation”

Dec 12, 2008 University of New Mexico, Grand Rounds – “An Evidence-based Clinical Transformation” Dec 7, 2008 Vermont Oxford Network Quality Congress, Washington DC – “Evidence-based EMR Implementation in Neonatology” Oct 13, 2008 Cerner Health Conference 2008 – “Activation Strategies for CPOE and Clinical Documentation” July 16, 2008 Cerner Regional User Group Keynote Speech – “Evidence-based EMR Implementations and Unintended Consequences” July 8, 2008 San Francisco Bay Area Chapter of ACM CHI – “Computer Human Interface in Healthcare IT” May 22, 2008 Stanford University School of Medicine, Introduction to Medicine for Innovators – “Electronic Medical Records 101” May 13, 2008 HP Health & Life Sciences Symposium, Orlando, FL – “Unintended Consequences of Technology in Healthcare” April 10, 2008 Child Health Corporation of America (CHCA) annual CIO/CMIO meeting – “Evidence-based EMR Implementation” March 27, 2008 San Ramon Regional Medical Center, CA – Grand Rounds on “Evidence-based Implementation of CDS Systems” March 25, 2008 Children's Hospital of Oakland, CA – Grand Rounds on “Evidence-based EMR Implementation in a Children’s Hospital”

July 11, 2007 Community Hospital of Monterey Peninsula, Monterey, CA – Grand Rounds on “CPOE and Patient Safety” January 29, 2007 EHR and E-Prescribing Summit, Anaheim, CA – “Unintended Consequences of Healthcare IT Implementations” Oct 9-11, 2006 Cerner Health Conference 2006 – “Automating the Physician Signout Process,” “Evidence-based Preparation for CPOE,” and “Optimizing Information Retrieval for Physicians”

May 8, 2006 UC Davis Medical Informatics lecture series, Sacramento, CA – “CPOE, Patient Safety, and Pediatric Informatics” Oct 10, 2005 Cerner Health Conference, Orlando, FL – Co-speaker on panel “Improving Physician Collaboration and Workflow” 2004 – 2006 AAP Life After Residency; Invited to represent careers in medical informatics at a panel session. April 25, 2001 Electronic Medical Records (EMR 210), UC Davis; Invited to guest lecture on “Handheld Computers in Medicine” November 30, 2000 Introduction to Medical Informatics (MDI 210), UC Davis; Invited to guest lecture on “Medical Decision Making” September 12, 2000 Physician Scientist Training Program, UC Davis; “Diagnostic Decision Support for Congenital Heart Disease”

MAJOR COMMITTEE ASSIGNMENTS, AFFILIATED INSTITUTIONS

2018 – current Initiative Management Council (Member) UC San Diego Health Radiology Information Systems Steering Committee (Co-Chair) UC San Diego Health 2017 – current Quality Council (Member) UC San Diego Health External Quality Reporting Task Force (Co-Chair) UC San Diego Health Enterprise Systems Renewal Executive Committee (Member) UC San Diego campus Laboratory Information Systems Steering Committee (Co-Chair) UC San Diego Health Clinical IT Executive Committee (Member) UC Irvine Health EMR Collaboration Steering Committee (Co-Chair) UC Riverside Health 2016 – current Information Services Executive Committee (Chair) UC San Diego Health Cybersecurity Executive Oversight (Member) UC San Diego campus Telemedicine Collaborative Executive Committee (Member) UCOP / UC Health PRIME Executive Oversight (Member) UC San Diego Health 2015 – current IT Services Governance Committee (Member) UC San Diego campus Executive Governing Body (ad-hoc member) UC San Diego Health Operational Excellence Steering Council (Member) UC San Diego Health

2010 – 2015 Stanford faculty search committees Department of Radiology search for Associate Chair of Radiology Informatics Department of Radiology search for Pediatric Radiologist with Clinical Informatics Department of Medicine search for Associate Dean of Clinical Research Informatics 2013 – 2015 Transforming Patient Care, Ad Hoc Committee of the Dean Stanford School of Medicine 2011 – 2015 Stanford Center for Clinical Informatics Advisory Committee (Member) Stanford School of Medicine 2011 – 2015 Lane Library Advisory Committee Stanford School of Medicine 2010 – 2015 Medical Executive Committee (Member) LPCH 2010 – 2015 Faculty Practice Organization Leadership Committee (Member) LPCH 2010 – 2015 Information Services Board Subcommittee (Non-voting attendee) LPCH 2009 – 2015 Information Services Executive Committee (Member) LPCH 2009 – 2015 Information Services Strategic Team (Member) LPCH 2008 – 2015 Information Services Physician Advisory Group (Chair) LPCH 2008 – 2015 Clinical Resource Management Oversight Committee (Member) LPCH

Printed March 31, 2019 (Page 5 of 11) Christopher A. Longhurst, MD, MS

MAJOR COMMITTEE ASSIGNMENTS, AFFILIATED INSTITUTIONS

2006 – 2015 Electronic Order Set Committee (Chair) LPCH 2006 – 2012 Clinical Decision Support Committee (Chair) LPCH 2006 – 2008 Innovations in Patient Care grant committee (Member) LPCH 2006 – 2008 Integrated Documentation Committee (Chair) LPCH 2006 – 2008 Residency Selection Committee (Member) Stanford School of Medicine 2005 – 2015 Pediatric Informatics Rotation (Instructor of Record) Stanford School of Medicine 2005 – 2015 LPCH Information Services Leadership Committee (Member) LPCH 2004 – 2015 Clinical Transformation Project Management Oversight Committee (Member) LPCH 2004 – 2015 Quality Improvement Oversight Committee (Member) LPCH 2004 – 2015 Patient Safety Committee (Member) LPCH 2001 – 2006 Pediatric Housestaff Website (Editor) LPCH 1999 – 2001 Associate Dean of Medical Education Search Committee (student member) UC Davis School of Medicine 1997 – 2000 UCD SOM Admissions Committee (student member) UC Davis School of Medicine

MAJOR COMMITTEE ASSIGNMENTS, NATIONAL / INTERNATIONAL

2017 – current Washington University, St. Louis, MO – External Advisory Board member for Informatics Institute 2017 - current American Board of Preventive Medicine – Clinical Informatics board exam question writing committee 2010 – 2017 Association of Medical Directors of Information Systems (AMDIS) annual symposium planning committee 2014 – 2015 American Board of Pediatrics (ABP) Task Force on Informatics 2012 – 2015 Co-founder and advisor, CRIT (CDS Reducing Inappropriate Transfusions) quality improvement collaborative (http://CRIT.stanford.edu) which has eliminated tens of thousands of unnecessary blood transfusions across the US 2011 – 2014 HIMSS Physician IT symposium planning committee 2011 NHLBI Workshop on EHR Research Priorities to Improve Cardiopulmonary Health in Clinical Practice (http://www.nhlbi.nih.gov/meetings/workshops/ehr.htm) 2008 – 2010 Vermont Oxford Network – Neonatal Quality Improvement Collaborative (faculty) 2007 Created and organized NICHQ / NACHRI “Don’t Automate Junk” conference (3/18/2007)

EDITORIAL AND REVIEW BOARDS

2015 – current Learning Health Systems (Editorial Board member) 2012 – current Applied Clinical Informatics (Associate Editor) 2010 – current Healthcare Informatics (Editorial Advisory Board member)

2015 – current NEJM (ad hoc reviewer) 2009 – current Pediatrics (ad hoc reviewer) 2012 – current Journal of the Medical Informatics Association (JAMIA) 2018 – current Journal of the Medical Informatics Association (JAMIA) Open

INDUSTRY CONSULTING AND ADVISORY BOARDS

2019 – current Carequality Advisory Council (https://carequality.org/get-involved/advisory-council/)

2018 – current Leapfrog CPOE Expert Panel (http://www.leapfroggroup.org/survey-materials/survey-and-cpoe-materials)

2018 – current AT&T DirecTV Healthcare Advisory Council

2018 – current San Diego Mothers’ Milk Bank (https://health.ucsd.edu/specialties/obgyn/maternity/newborn/lactation/Pages/Mothers-Milk.aspx), the first milk bank in southern California, co-directed by Drs. Lisa Stellwagen and Jae Kim

2011 – current Medical advisory board member for Doximity (http://doximity.com), a physician-focused digital health startup founded by Jeff Tangney

2015 – current Advisory board member for Grand Rounds Health (https://www.grandrounds.com/), a second opinion service founded by Dr. Lawrence “Rusty” Hofmann

2011 – 2018 Advisory board member for HealthLoop (http://healthloop.com/), a consumer-focused digital health startup founded by Dr. Jordan Shlain, until acquisition by GetWell 2013 – 2015 Strategic advisory board for Spok (http://www.spok.com/meet-spok/SAC), a secure messaging solution used at Stanford

Printed March 31, 2019 (Page 6 of 11) Christopher A. Longhurst, MD, MS

INDUSTRY CONSULTING AND ADVISORY BOARDS

2013 – 2015 Medical advisory board member for Gobiquity Mobile Health (http://gobiquity.com), a mobile device start-up company 2013 – 2015 Medical advisory board member for Kyron (http://kyron.com/), a failed big data startup funded by Vinod Khosla

2012 – 2013 Independent contractor for Silver Lake Sumeru (http://www.silverlake.com/sumeru/) providing consultative review of potential acquisition targets and advice about optimizing value of current holdings

2010 Independent consultant for HealthTap (https://www.healthtap.com/), a health IT startup founded by Ron Gutman

2008 Independent contractor for Silver Lake (http://www.silverlake.com) providing investment advice about the potential acquisition of a high end clinical decision support company (UpToDate)

2008 – 2010 Faculty Expert for Vermont Oxford Network (http://www.vtoxford.org/) quality improvement collaborative focused on implementing an EMR in intensive care nurseries.

2009 Unpaid consultant to aid in EMR vendor selection process at Sidra Medical Center (http://sidra.org) in Doha, Qatar.

2008 Co-founder of Imler Longhurst & Greene (ILG), a failed health IT startup company focused on creating automated health advice for consumers.

2006 – 2007 Independent contractor helping to develop the Google Health product (http://google.com/health).

2005 – current Co-founder of BiliTool, LLC (http://bilitool.org), a freely available web-based tool for hyperbilirubinemia risk assessment.

2004 – 2005 Independent contractor for Epocrates (http://www.epocrates.com/) to help with pediatric content development and strategic direction.

MEDIA INTERVIEWS AND NEWS RELEASES (SELECTED)

Jan 24, 2018 UCSD among 12 nationwide to pilot Apple Inc. new medical records access system http://www.sandiegouniontribune.com/news/health/sd-no-apple-medicalrecords-20180124-story.html Aug 7, 2017 Epic Move: UC San Diego Health Transitions to Cloud Technology https://health.ucsd.edu/news/releases/Pages/2017-08-07-epic-move-uc-san-diego-health-transitions-to-cloud-technology.aspx July 10, 2017 UC San Diego Health Named among Nation’s “Most Wired” https://health.ucsd.edu/news/releases/Pages/2017-07-10-uc-san-diego-health-named-most-wired.aspx Nov 14, 2017 Epic Sharing within UC Health https://health.ucsd.edu/news/releases/Pages/2017-11-14-epic-sharing-within-uc-health.aspx June 19, 2017 University of California Health System CIOs Collaborate for Change https://www.healthcare-informatics.com/article/leadership/university-california-health-system-cios-collaborate-change Feb 2016 Making the Shift from CMIO to CIO: One New-ish CIO’s Perspective on the Transition http://www.healthcare-informatics.com/article/making-shift-cmio-cio-one-new-ish-cio-s-perspective-transition

June 2015 Always Looking Beyond the Horizon http://www.hitleadersandnews.com/always-looking-beyond-the-horizon-lucile-salter-packard-childrens-hospital-stanford/ Sept 17, 2014 Stanford, Duke to pilot Apple's HealthKit http://www.beckershospitalreview.com/healthcare-information-technology/stanford-duke-to-pilot-apple-s-healthkit.html Oct 29, 2014 Becker’s Hospital Review: 25 CMIO’s to know http://www.beckershospitalreview.com/lists/25-cmios-to-know.html Oct 5, 2014 Can Big Data Tell Us What Clinical Trials Don’t? http://nyti.ms/YXs7TG Sept 15, 2014 Two Apple medical trials shed light on how HealthKit will work http://www.reuters.com/article/2014/09/15/us-apple-health-idUSKBN0HA0Y720140915 Aug 20, 2014 HIStalk interviews Chris Longhurst, CMIO at Stanford Children’s Health http://histalk2.com/2014/08/20/histalk-interviews-chris-longhurst-md-ms-cmio-stanford-childrens-health/ Aug 14, 2014 The challenge of developing a CI fellowship program http://www.cmio.net/topics/health-it/challenge-developing-clinical-informatics-fellowship-program April 2014 Medical Informatics: A Formal Subspecialty Whose Time Has Come http://www.healthcare-informatics.com/article/medical-informatics-formal-subspecialty-whose-time-has-come Dec 2013 Clinical informatics gains recognition as new medical sub-specialty http://scopeblog.stanford.edu/2013/12/19/clinical-informatics-gains-recognition-as-new-medical-sub-specialty/ June 2012 Healthcare Informatics: EMR Usability http://www.healthcare-informatics.com/article/web-exclusive-interview-jin-hahn-md-and-christopher-longhurst-md March 2012 Healthcare Informatics: “The Clinical Alerts that Cried Wolf” http://www.healthcare-informatics.com/article/clinical-alerts-cried-wolf January 2012 Healthcare Informatics: “A Breakthrough in Harnessing EHR-Derived Data” http://www.healthcare-informatics.com/article/industry-exclusive-interview-breakthrough-harnessing-ehr-derived-data

Printed March 31, 2019 (Page 7 of 11) Christopher A. Longhurst, MD, MS

MEDIA INTERVIEWS AND NEWS RELEASES (SELECTED)

August 2011 Healthcare Informatics interview on “Leveraging Data for Clinical Performance Improvement” http://www.healthcare-informatics.com/article/leveraging-data-clinical-performance-improvement-0 June 2011 Healthcare Informatics interview on “CPOE and Patient Safety” http://www.healthcare-informatics.com/article/cpoe-and-patient-safety March 2011 Mobile Healthcare Anywhere http://www.healthcare-informatics.com/article/mobile-healthcare-anywhere Dec 9, 2010 Health Leaders interview http://www.healthleadersmedia.com/print/TEC-259946/CPOEs-Can-Decrease-Mortality-Rates-Research-Shows Nov 7, 2010 Modern Healthcare magazine Top 25 Clinical Informaticist http://www.modernhealthcare.com/article/20101108/MAGAZINE/101109980 Sept 1, 2010 Today’s Hospitalist http://todayshospitalist.com/index.php?b=articles_read&cnt=1047 June 25, 2010 Silicon Valley Business Journal: Lucile Packard Children's Hospital at Stanford's new CMIO takes reins http://sanjose.bizjournals.com/sanjose/stories/2010/06/28/story4.html May 3, 2010 Healthcare IT News: Study correlates CPOE with decreased mortality rates http://www.healthcareitnews.com/news/study-correlates-cpoe-decreased-mortality-rates May 3, 2010 Reuters: Electronic medical orders may save lives http://www.reuters.com/article/idUSTRE64216U20100503 May 3, 2010 Modern Healthcare: CPOE may be tied to lower mortality: study http://www.modernhealthcare.com/article/20100503/NEWS/305029987 May 3, 2010 WSJ: At One Hospital, Computerized Order System Cut Mortality By 20% http://blogs.wsj.com/health/2010/05/03/stanford-hospital-computerized-order-system-cut-mortality-by-20/ April 29, 2010 CMIO magazine on Gaining MD Buy-in for CPOE http://www.cmio.net/index.php?option=com_articles&id=21826 June 4, 2009 Sacramento NPR interview on the topic of PHR’s http://www.capradio.org/articles/articledetail.aspx?articleid=6709 July 8, 2008 KTSF TV interview on Avoiding Heat-related Illness in Children http://www.youtube.com/watch?v=r1S5QUZks_s Oct 8, 2007 The IT Doctor is In – video blog interview with Robert Scoble http://www.podtech.net/home/4325/the-it-doctor-is-in July 5, 2007 National NPR interview on dehydration in children http://www.npr.org/templates/story/story.php?storyId=11744838

INVITED BOOK CHAPTERS (REVERSE CHRONOLOGIC ORDER)

1. Christopher A. Longhurst. Innovations in Interventional Informatics. In Edward W. Marx, Voices of Innovation: Fulfilling the Promise of Information Technology in Healthcare. CRC Press, 1st Edition, 2019. 2. Sitapati AM, Longhurst CA. Analytics and Population Health. In Richard Rydell and Howard Landa (Eds), The CMIO Survival Guide. 2nd Edition. CRC Press, Boca Raton, FL, 2018. 3. Dean F. Sittig, Christopher A. Longhurst, Elise Russo, Hardeep Singh. Electronic Health Record Features, Functions, and Privileges that Users Need to Provide Safe and Effective Care for Adults and Children. In Marion Ball, George Kim, Joan Kiel, and Charlotte Weaver (Eds), Health Information Management: Reality, Visions and Future Roadmaps. 4th Edition, 2015. 4. Longhurst CA, Sharp C. From Implementation to Operations. In Thomas Payne (Ed), Practical Guide to Clinical Computing Systems. Design, Operations, and Infrastructure. Elsevier; New York, NY, 2014.

PEER-REVIEWED PUBLICATIONS - HTTPS://ORCID.ORG/0000-0003-4908-6856 (REVERSE CHRONOLOGIC ORDER)

1. Time requirements of paper-based clinical workflows and after-hours documentation in a multi-specialty academic ophthalmology practice. American Journal of Ophthalmology. 2019. 2. Tai-Seale M, Downing NL, Jones VG, Milani RV, Zhao B, Clay B, Sharp CD, Chan AS, Longhurst CA. Technology-Enabled Consumer Engagement: Promising Practices At Four Health Care Delivery Organizations. Health Aff (Millwood). 2019 Mar;38(3):383-390. PMID 30830826. 3. Dameff C, Clay B, Longhurst CA. Personal Health Records: More Promising in the Smartphone Era? JAMA. 2019 Jan 11. PMID 30633300. 4. Wright A, Ash J, Aaron S, Ai A, Hickman TT, Wiesen JF, Galanter W, McCoy AB, Schreiber R, Longhurst CA, Sittig DF. Best Practices for ensuring reliability of clinical decision support systems: results of a Delphi study. Int J Med Inform. 2018. PMID 30153926. 5. Downing NL, Bates DW, Longhurst CA. Physician Burnout in the EHR Era: Are We Ignoring the Real Cause? Ann Int Med. 2018 May 8. PMID 29801050. 6. Sittig DF, Salimi M, Aiyagari R, Banas C, Clay B, Gibson KA, Goel A, Hines R, Longhurst CA, Mishra V, Sirajuddin AM, Satterly T, Singh H. Adherence to recommended electronic health record safety practices across eight health care organizations. J Am Med Inform Assoc. 2018 Apr 26. PMID 29701854. 7. Tjen-A-Looi SC, Longhurst CA. Dr. John Longhurst, M.D., Ph.D. (1947-2018). Am J Physiol Heart Circ Physiol. 2018 Mar 30. doi: 10.1152/ajpheart.00169.2018. PMID 29600894. 8. Marmor RA, Clay B, Millen M, Savides TJ, Longhurst CA. The Impact of Physician EHR Usage on Patient Satisfaction. Appl Clin Inform. 2018 Jan;9(1):11-14. PMID 29298451. 9. Kipps AK, Poole SF, Slaney C, Feehan S, Longhurst CA, Sharek PJ, Goel VV. Implementation of Data-Driven Vital Sign Parameters to

Printed March 31, 2019 (Page 8 of 11) Christopher A. Longhurst, MD, MS

INVITED BOOK CHAPTERS (REVERSE CHRONOLOGIC ORDER)

Decrease Monitor Alarm Burden on an Acute Care Unit. Pediatrics. 2017 Jul 7. pii: e20162458. PMID 28687637. 10. DiAngi YT, Longhurst CA, Payne TH. Taming the EHR (Electronic Health Record) - There is Hope. J Fam Med. 2016;3(6). pii: 1072. 2016 Jul. PMID 27830215. 11. Chaparro JD, Classen DC, Danforth M, Stockwell DC, Longhurst CA. National trends in safety performance of electronic health record systems in children's hospitals. J Am Med Inform Assoc. 2016 Sep 16. PMID 27638908. 12. Goel VV, Poole SF, Longhurst CA, Platchek TS, Pageler NM, Sharek PJ, Palma JP. Safety Analysis of Proposed Data-Driven Physiologic Alarm Parameters for Hospitalized Children. J Hosp Med. 2016 Jul 14. PMID 27411896. 13. Downing NL, Adler-Milstein J, Palma JP, Lane S, Eisenberg M, Sharp C, Northern California HIE Working Group, Longhurst CA. Health information exchange policies of 11 diverse health systems and the associated impact on volume of exchange. J Am Med Inform Assoc. 2016 Jun 14. PMID 27301748. 14. Longhurst CA, Pageler NM. Palma JP, Finnell JT, Mohan V, Hersh WR. Early Experiences of Accredited Clinical Informatics Fellowships. J Am Med Inform Assoc. 2016 May 20. PMID 27206458. 15. Stark DE, Kumar RB, Longhurst CA, Wall DP. The Quantified Brain: A Framework for Mobile Device-Based Assessment of Behavior and Neurological Function. App Clin Info, 2016. PMID 27437041. 16. Sutherland SM, Kaelber DC, Downing NL, Goel VV, Longhurst CA. Electronic Health Record-Enabled Research in Children: Using the Electronic Health Record for Clinical Discovery. Pediatr Clin North Am. 2016 Apr;63(2):251-268. PMID 27017033. 17. RB Kumar; ND Goren; DE Stark; DP Wall; CA Longhurst. Automated integration of continuous glucose monitor data in the electronic health record using consumer technology. J Am Med Inform Assoc. 2016. PMID 27018263. 18. Pageler NM, Grazier G’Sell MJ, Chandler W, Mailes E, Yang C, Longhurst CA. A rational approach to legacy data validation when transitioning between electronic health record systems. J Am Med Inform Assoc. 2016 Mar 14. PMID 26977100. 19. Meyer AN, Longhurst CA, Singh H. Crowdsourcing Diagnosis for Patients With Undiagnosed Illnesses: An Evaluation of CrowdMed. J Med Internet Res 2016;18(1):e12. PMID 26769236. 20. Algaze CA, Wood M, Pageler NM, Sharek PJ, Longhurst CA, Shin AY. Use of a Daily Checklist and Clinical Decision Support Tool Reduces Laboratory Utilization and Improves Cost. Pediatrics. 2016 Jan;137(1). PMID 26681782 21. Adams ES, Longhurst CA. Clinical Decision Support For Pediatric Blood Product Prescriptions. J Pediatr Intensive Care 2016; 05(03): 108- 112. PMID PENDING. 22. Gallego B, Walter SR, Day RO, Dunn AG, Sivaraman V, Shah N, Longhurst CA, Coiera E.. Bringing cohort studies to the bedside: Framework for a ‘green button’ to support clinical decision-making. J Comp Eff Res. 2015 May 11:1-7. PMID 25959863. 23. Lehmann CU, Longhurst CA, Hersh WR, Mohan V, Levy BP, Embi PJ, Turner AM, Martin R, Williams J, Munger B. Clinical Informatics Fellowship Programs: In Search of a Viable Financial Model. Appl Clin Inform. PMID 26171074. 24. Nagata JM, Charville GW, Klotz JM, Wickremasinghe W, Kann D, Schwenk H, Longhurst CA. Bordetella petrii sinusitis in an immunocompromised adolescent. Pediatr Infect Dis J. 2015 Apr;34(4):458. PMID 25760569. 25. McCarthy LH, Longhurst CA, Hahn JS. Special Requirements for Electronic Medical Records in Neurology. Neurol Clin Pract. 2015 Feb;5(1):67-73. PMID 25717421. 26. Stevens LA, Pantaleoni J, Longhurst CA. The Value of Clinical Teachers for EMR Implementations and Conversions. Appl Clin Inform. 2015 Feb 11;6(1):75-9. PMID 25848414. 27. Pantaleoni J, Stevens LA, Goad B, Mailes E, Longhurst CA. Successful Physician Training Program for Large Scale EMR Implementation. Appl Clin Inform. 2015 Feb 11;6(1):80-95. PMID 25848415. 28. Park K, Park MD, Longhurst CA. Patient and Family Access to Electronic Health Records: A Key Ingredient for a Pediatric Learning Health System. J Particip Med. 2015;7. pii: e2. PMID 25664199. 29. Sutherland SM, Byrnes JJ, Kothari M, Longhurst CA, Dutta S, Garcia P, Goldstein SL. AKI in Hospitalized Children: Comparing the pRIFLE, AKIN, and KDIGO Definitions. Clin J Am Soc Nephrol. 2015 Feb 3. PMID 25649155. 30. Longhurst CA, Harrington RA, Shah NH. A ‘Green Button’ For Using Aggregate Patient Data At The Point Of Care. Health Aff (Millwood). 2014 Jul 1;33(7):1229-35. PMID 25006150. 31. May LJ, Longhurst CA, Pageler NM, Wood MS, Sharek PJ, Zebrack CM. Optimizing Care of Adults with Congenital Heart Disease in a Pediatric Cardiovascular Intensive Care Unit Using Electronic Clinical Decision Support. Pediatr Crit Care Med. 2014 Apr 11. PMID 24732291. 32. Pageler NM, Longhurst CA, Wood M, Cornfield DN, Suermondt J, Sharek PJ, Franzon D. An EMR-Enhanced Checklist in Combination with a Unit-wide Electronic Dashboard is Associated with Decreased Central Line Associated Blood Stream Infections. Pediatrics. 2014 Mar;133(3):e738-46. PMID 24567021. 33. Harper MB, Longhurst CA, McGuire TL, Tarrago R, Desai BR, Patterson A, on behalf of the Children’s Hospital Association CDS Working Group. Core drug-drug interaction alerts for inclusion in pediatric electronic health records with computerized prescriber order entry.J Patient Saf. 2014 Feb 11. PMID 24522227. 34. Pageler NM, Friedman CP, Longhurst CA. Refocusing Medical Education in the EMR Era. JAMA. 2013 Dec 4;310(21):2249-50. PMID 24302083. 35. Sittig DF, Singh H, Longhurst CA. Rights and responsibilities of EHR users caring for children. Arch Argent Pediatr 2013;111(6):468-471. PMID 24196758. 36. Longhurst CA, Palma JP, Grisim LM, Chan M, Widen E, Sharek PJ. Evidence-based EMR Implementation. J Healthc Inf Manag. 2013 Summer;27(3):79-83. PMID 24771994. 37. Carandang F, Anglemyer A, Longhurst CA, Krishnan G, Alexander SR, Kahana M, Sutherland SM. Association between Maintenance Fluid Tonicity and Hospital-Acquired Hyponatremia. J Pediatr. 2013 Aug 30. pii: S0022-3476(13)00878-0. PMID 23998517. 38. Stevens LA, Palma JP, Pander KK, Longhurst CA. Immunization registries in the EMR Era. Online J Public Health Inform. 2013;5(2). PMID 23923096. 39. Carspecken CW, Sharek PJ, Longhurst CA, Pageler NM. A Clinical Case of Electronic Health Record Drug Alert Fatigue: Consequences for Patient Outcome. Pediatrics. 2013 Jun;131(6):e1970-3. PMID 23713099. 40. Tierney M, Pageler N, Kahana M, Pantaleoni J, Longhurst CA. Medical Education in the EMR Era. Acad Med. 2013 Jun;88(6):748-752. PMID 23619078. 41. Pageler NM, Franzon D, Longhurst CA, Wood M, Shin AY, Adams ES, Widen E, Cornfield DN. Embedding Limits on the Duration of

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INVITED BOOK CHAPTERS (REVERSE CHRONOLOGIC ORDER)

Laboratory Orders within Computerized Provider Order Entry Decreases Laboratory Utilization. Pediatr Crit Care Med. 2013 Feb 22. PMID 23439456. 42. Palma JP, Keller H, Godin M, Wayman K, Cohen RS, Rhine WD, Longhurst CA. Impact of an EMR-Based Daily Patient Update Letter on Communication and Parent Engagement in a Neonatal Intensive Care Unit. J Particip Med. 2012 Dec 31;4. pii: e33. PMID 23730532. 43. Shin AY, Longhurst C, Sharek PJ. Reducing Mortality Resulting from Adverse Events. Pediatr Clin North Am. 2012 Dec;59(6):1293-306. doi: 10.1016/j.pcl.2012.09.002. Epub 2012 Oct 10. PMID 23116526. 44. Gaskin GL, Longhurst CA, Anoshiravani A. Internet Access and Attitudes towards Online Personal Health Information Among Detained Youth. Pediatrics. 2012 Nov;130(5):914-7. doi: 10.1542/peds.2012-1653. Epub 2012 Oct 22. PMID 23090346. 45. Anoshiravani A, Gaskin GL, Groshek MR, Kuelbs C, Longhurst CA. Special requirements for electronic medical records in adolescent medicine. J Adolesc Health 2012;(51):409-14. PMID 23084160. 46. Patel SJ, Longhurst CA, Lin A, Garrett L, Gillette-Arroyo J, Mark JD, Wood M, Sharek PJ. Integrating the Home Management Plan of Care into an EMR Improves Compliance with Asthma Core Measures. Joint Commission Journal of Quality and Patient Safety. Aug 2012. PMID 22946253. 47. Hahn JS, Bernstein JA, McKenzie RB, King BJ, Longhurst CA. Rapid Implementation of Inpatient Electronic Physician Documentation at an Academic Hospital. Appl Clin Inform. Vol. 3: Issue 2 2012. 175-185. PMID 23620718. 48. Palma JP, Benitz WE, Tarczy-Hornoch P, Butte AJ, Longhurst CA. Neonatal Informatics: Transforming Neonatal Care through Translational Bioinformatics. NeoReviews. 2012; 13:e281-e284. PMID: 22924023 49. Longhurst CA, Landa HM. Health information technology and patient safety. BMJ 2012;344:e1096. PMID: 22349580. 50. Palma JP, Brown PJ, Lehmann CU, Longhurst CA. Neonatal Informatics: Optimizing Data Entry and Display. NeoReviews. Vol. 13 No. 2 February 1, 2012 pp. e81 -e85. PMID: 22557935. 51. Grisim LM, Longhurst CA. An evidence-based approach to activating your EMR. Healthc Inform. 2011 Dec;28(12):47-8, 50. PMID: 22233021. 52. Frankovich J, Longhurst CA, Sutherland SM. Evidence-based Medicine in the EMR Era. N Engl J Med. 2011 Nov 10;365(19):1758-9. Epub 2011 Nov 2. PMID: 22047518. 53. Palma JP, Van Eaton EG, Longhurst CA. Neonatal Informatics: Information Technology to Support Handoffs in Neonatal Care. NeoReviews. Vol. 12 No. 10 October 1, 2011 pp. e560 -e563. PMID: 22199463. 54. Gaskin GL, Longhurst CA, Slayton R, Das AK. Sociotechnical Challenges of Developing an Interoperable Personal Health Record: Lessons Learned. Appl Clin Inform. October 2011. PMID: 22003373. 55. Ryan .C, Khan M, Delgado E, Berquist W, Longhurst C. A 15-Year-Old Girl with Dysphagia, Failure to Thrive. Pediatr Ann. 2011 Aug;40(8):397-400. PMID: 21815600. 56. Anoshiravani A, Gaskin GL, Wilson T, Kopetsky E, Sandborg C, Longhurst CA. Implementing an interoperable personal health record in pediatrics: lessons learned at an academic children’s hospital. J Participat Med. 2011 Jul 11; 3:e30. PMID: 21853160. 57. Palma JP, Sharek PJ, Classen DC, Longhurst CA. Neonatal Informatics: Computerized Physician Order Entry. NeoReviews, 2011;12:393-396. PMID: 21804768. 58. Adams ES, Longhurst CA, Pageler N, Widen E, Franzon D, Cornfield DN. Computerized physician order entry with decision support decreases blood transfusions in hospitalized children. Pediatrics. 2011 May;127(5):e1112-9. Epub 2011 Apr 18. PMID: 21502229. 59. Palma JP, Sharek PJ, Longhurst CA. Impact of Electronic Medical Record Integration of a Handoff Tool on Sign-out in a Newborn Intensive Care Unit. J. Perinatology. 2011 May;31(5):311-7. Epub 2011 Jan 27.PMID: 21273990. 60. Barreto-Chang OL, Pearson D, Shepard WE, Longhurst CA, Greene A. Vitamin D Deficient Rickets in a Child with Cow’s Milk Allergy. Nutrition in Clinical Practice. 2010 Aug;25(4):394-8. PMID: 20702845. 61. Longhurst CA, Parast L, Sandborg CI, Widen E, Sullivan J, Hahn JS, Dawes CG, Sharek PJ. Decrease in Hospital-wide Mortality Associated with Implementation of a Comprehensive Electronic Medical Record. Pediatrics. 2010 Jul;126(1):14-21. Epub 2010 May 3. PMID 20439590. 62. Bernstein J, Imler D, Sharek P, Longhurst C. Improved Physician Workflow and Satisfaction after Integration of Sign-out Notes into the EMR. Joint Commission Journal of Quality and Patient Safety, Feb 2010. PMID: 20180439. 63. Longhurst CA, Turner S, Burgos A. Development of a web-based decision support tool to increase use of neonatal hyperbilirubinemia guidelines. Joint Commission Journal of Quality and Patient Safety. May 2009. PMID: 19480378. 64. Longhurst CA, Sharek PJ, Hahn J, Sullivan J, Classen D. Perceived increase in mortality after process and policy changes implemented with computerized physician order entry. Pediatrics. 2006 Apr;117(4):1450-1. PMID: 16585351. 65. Nguyen TC, Battat A, Longhurst C, Peng PD, Curet MJ. Alphanumeric paging in an academic hospital setting. Am J Surg. 2006; 191:4:561-5. PMID: 16531156. 66. Agarwal SA, Trucco S, Longhurst C, Sectish TC. Index of Suspicion. Pediatrics in Review. 2004; 25: 364-366. PMID: 15466138. 67. Longhurst C, Naumovski L, Garcia M, Kerner J. A practical guideline for calculating parenteral nutrition cycles. Nutrition in Clinical Practice. 2003; 18:517-520. PMID: 16215087. 68. Longhurst C, West DC. Isolation of Leclercia adecarboxylata in an Infant with Acute Lymphoblastic Leukemia. Clin Infect Dis. 2001;32:1659. PMID: 11340546.

PEER-REVIEWED ABSTRACTS AND POSTERS

1. Goel V, Poole S, Kipps A, Palma J, Platchek T, Pageler N, Longhurst C, Sharek P. Implementation of Data Driven Heart Rate and Respiratory Rate Parameters on a Pediatric Acute Care Unit. Presented at MedInfo, Sao Paulo, Brazil. Stud Health Technol Inform. 2015;216:918. PMID 26262220. 2. Downing NL, Lane S, Eisenberg M, Sharp C, Palma J; Northern California HIE Working Group, Longhurst C. Exponential Increase in Regional Health Information Exchange With Collaborative Policies and Technologies. Presented at MedInfo, Sao Paul, Brazil. Stud Health Technol Inform. 2015;216:931. PMID 26262233.

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PEER-REVIEWED ABSTRACTS AND POSTERS

3. Investigating rare clinical events using EMR data: Turning case reports into case series. Accepted for presentation at AMIA Translational Bioinformatics symposium, Spring 2015. 4. Veena V. Goel, Sarah F. Poole, Terry S. Platchek, Christopher A. Longhurst, Paul J. Sharek, Jonathan P. Palma. Data Driven Approach to Vital Sign Parameters at Lucile Packard Children’s Hospital Stanford (LPCH). American Medical Informatics Association annual symposium, Nov 17, 2014. 5. Andrew Y. Shin, Claudia Algaze, Matthew Wood, Natalie Pageler, Stephen J. Roth, Paul Sharek, Christopher Longhurst. Impact of Clinical Resource Management: Optimizing Laboratory Utilization Is Associated with Reduced Cost and Improved Patient Outcomes. Pediatric Cardiac Intensive Care Society 9th International Symposium. December 9-12, 2012. 6. Jennifer D Frankovich, Chris Longhurst, Scott Sutherland, Christy I Sandborg. Real-Time, Cohort-Based Clinical Decision Support Using a Novel Bioinformatics Platform to Assess Thrombotic Risk in a Critically Ill Pediatric Patient with Systemic Lupus Erythematosus. Arthritis and Rheumatism. November 2012. 7. Even Kirshenbaum, Natalie Pageler, Chris Longhurst, Marige Godin, Andy Shin, Deb Franzon, Jessica Wayne. Enabling Clinicians to Directly Deploy Clinical Logic in a Patient Safety Dashboard. AMIA Annual Conference. 2012. 8. Francis Carandang, Andrew Anglemyer, Gomathi Krishnan, Chris Longhurst, Madelyn Kahana, Scott Sutherland. Hypotonic versus Isotonic Saline IV Fluid Hydration: Increased Risk of Hyponatremia? Society for Critical Care Medicine annual meeting 2012. 9. Eloa Adams, Christopher A. Longhurst, Natalie Pageler, Eric Widen, Deborah Franzon, David N. Cornfield. A decision support algorithm tethered to computerized physician order entry decreases the use of blood products in a acutely ill children. PAS 2010. 10. Deborah Franzon, Natalie Pageler, Eric Widen, Christopher A. Longhurst, David N. Cornfield. Computerized Provider Order Entry (CPOE) Can Enhance the Efficiency of Laboratory Testing Utilization in the Pediatric Intensive Care Unit. PAS 2010. 11. Natalie Pageler, Luanne Smith, Chris Longhurst, Nathan Luna, David Cornfield. Automated Determination of Pediatric Risk of Mortality (PRISM) via the Electronic Medical Record (EMR) Improves Efficiency and Reliability. Society of Critical Care Medicine’s (SCCM) 39th Critical Care Congress, 2010 12. Natalie Pageler, Chris Longhurst, Andrew Shin, Eloa Adams, Eric Widen, David Cornfield. Using Computerized Provider Order Entry (CPOE) to promote sustained optimization of diagnostic radiologic service utilization. Society of Critical Care Medicine’s (SCCM) 39th Critical Care Congress, 2010. 13. Andreas M. Kogelnik, Paul J. Sharek, Chris Longhurst, Jaap Suermondt, Atul J. Butte. Automated Risk Assessment for Prediction of Pediatric Adverse Events. Proceedings AMIA 2009. 14. Chris Longhurst, Stuart Turner, Anthony Burgos. Use of AAP Hyperbilirubinemia Guidelines with and Without Use of a Web-Based Clinical Decision Support Tool, PAS 2006:59:5575.476. 15. Jon Palma, Chris Longhurst. Interactive Training Increases Resident Acceptance of a New Electronic Medical Record. PAS 2006:59:252. 16. Chris Longhurst, Stuart Turner, Anthony Burgos. A Web-Based Tool for Assigning Hyperbilirubinemia Risk in the Newborn. PAS 2005: 57: 3156. 17. Anthony Burgos, Chris Longhurst. Total Serum Bilirubin in newborn Latino infants: Application of the hour-specific Bilirubin Nomogram. PAS 2005: 57: 1923. 18. Longhurst CA, Kraft, DL, Sectish, TC. Internet-based Alphanumeric Paging: A useful tool for rapid, convenient, and effective hospital communication. American Academy of Pediatrics Annual Conference, Boston, MA, October 2002. 19. Stahl GL, Longhurst CA. Complement mediated loss of endothelium-dependent relaxation in porcine coronary arteries [Abstract], FASEB Journal, 1994, 1:A537.

Printed March 31, 2019 (Page 11 of 11)

Curriculum Vitae Joseph D. Ma, PharmD, FCP

OFFICES University of California, San Diego (UCSD) Skaggs School of Pharmacy & Pharmaceutical Sciences 9500 Gilman Drive, MC 0714 La Jolla, CA 92093-0714 858.822.3485 858.822.6857 FAX [email protected]

University of California, San Diego, Medical Center Doris A. Howell Pain & Palliative Care Service Moores Cancer Center 3855 Health Sciences Drive, MC 0658 La Jolla, CA 92093-0658 858.534.7079 858.822.3449 FAX

APPOINTMENTS 2007 – 2013 Assistant Professor of Clinical Pharmacy University of California, San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences La Jolla, CA

2013 – 2017 Associate Professor of Clinical Pharmacy University of California, San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences La Jolla, CA

2017 – Present Professor of Clinical Pharmacy University of California, San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences La Jolla, CA

2010 – Present Pain and Palliative Care Clinical Pharmacist University of California, San Diego Medical Center Doris A. Howell Pain & Palliative Care Consult Service Moores Cancer Center La Jolla, CA

EDUCATION AND TRAINING 1993 – 1998 University of California at Irvine, Irvine, CA Bachelor of Sciences, Biological Sciences 1998 – 2002 University of California at San Francisco, San Francisco, CA Doctor of Pharmacy 2002 – 2004 Bassett Healthcare, Cooperstown, NY Fellowship in Clinical Pharmacology

LISCENSURE 2002 – Present California RPH 53980 2011 – Present Drug Enforcement Agency (DEA) MM2428705 2011 – Present National Provider Identifier (NPI) 1164720900

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PEER REVIEWED ORIGINAL RESEARCH 1. Schindler C, Thorndike E, Ma JD, Goldberg S. Conditioned suppression with cocaine as the unconditioned stimulus. Pharmacology, Biochemistry and Behavior 2000; 65:83-89.

2. Ma JD, Nafziger AN, Kashuba ADM, Kim MJ, Gaedigk A, Rowland E, Kim JS, Bertino JS, Jr. Limited sampling strategy of S-warfarin concentrations but not warfarin S/R ratios accurately predicts S-warfarin AUC during baseline and inhibition in CYP2C9 extensive metabolizers. Journal of Clinical Pharmacology 2004; 44:570-576.

3. Ma JD, Nafziger AN, Rhodes G, Liu S, Gartung AM, Bertino JS, Jr. The effect of oral pleconaril on hepatic cytochrome P450 3A activity in healthy adults using intravenous midazolam as a probe. Journal of Clinical Pharmacology 2006; 46:103-108.

4. Ma JD, Nafziger AN, Villano SA, Gaedigk A, Bertino JS, Jr. Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults. Antimicrobial Agents and Chemotherapy 2006; 50:1130-1135.

5. Ma JD, Nafziger AN, Rhodes G, Liu S, Bertino JS, Jr. Duration of pleconaril effect on cytochrome P450 3A activity in healthy adults using the oral biomarker midazolam. Drug Metabolism and Disposition 2006; 34:783-785.

6. Ma JD, Lawendy NM, Fullerton T, Snyder PJ, Nafziger AN, Bertino JS, Jr. Effect of intravenous flumazenil on oral midazolam pharmacokinetics and pharmacodynamics for use as a cytochrome P450 3A probe. International Journal of Clinical Pharmacology and Therapeutics 2009; 47:111-119.

7. Ma JD, Nguyen ET, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Lee LS. Assessment of oral midazolam limited sampling strategies to predict area under the concentration time curve (AUC) during cytochrome P450 (CYP) 3A baseline, inhibition and induction or activation. International Journal of Clinical Pharmacology and Therapeutics 2010; 48:847-853.

8. Lawson EB, Wu JC, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim DS, Yin OQP, Capparelli EV, Ma JD. Omeprazole limited sampling strategies to predict area under the concentration-time ratios: implications for cytochrome P450 (CYP) 2C19 and 3A phenotyping. European Journal of Clinical Pharmacology 2012; 68:407-413.

9. Nguyen AN, Hoffman JT, Tsunoda SM, I-J Jang, Ma JD. Evaluation of intravenous midazolam limited sampling models to determine area under the concentration time curve during cytochrome P450 3A baseline, inhibition, and induction or activation. International Journal of Clinical Pharmacology and Therapeutics 2012; 50(7):468-475.

10. Wu JC, Nafziger AN, Bertino JS Jr, Ma JD. Limitations of S-warfarin truncated area under the concentration-time curve to predict cytochrome P450 2C9 activity. Drug Metabolism Letters 2012; 6(2):94-101.

11. Lee KC, Ma JD, Hudmon KS, Kuo GM. A train-the-trainer approach to a shared pharmacogenomics curriculum for US colleges and schools of pharmacy. American Journal of Pharmaceutical Education 2012; 76(10): Article 193.

12. Kuo GM, Lee KC, Ma JD. Implementation and outcomes of a live continuing education program on pharmacogenomics. Pharmacogenomics 2013; 14(8):885-895.

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13. Ettouati WE, Hirsch JD, Ma JD. Design and implementation of an interdisciplinary elective course in drug discovery, development, and commercialization. Innovations in Pharmacy 2013, 4(3):1-10.

14. Tai W, Gong SL, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Stoch SA, Ma JD. Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping. Drug Metabolism and Drug Interactions. 2013; 28(4):217-223.

15. Guo AY, Ma JD, Best BM, Atayee RS. Urine specimen detection of concurrent non-prescribed medicinal and illicit drug use in patients prescribed buprenorphine. Journal of Analytical Toxicology 2013; 37(9):636-641.

16. Moy KV, Ma JD, Best BM, Atayee RS. Factors impacting variability of urinary normeperidine to meperidine metabolic ratio in patients with chronic pain. Journal of Analytical Toxicology 2014; 38(1):1-7.

17. Yee DA, Atayee RS, Best BM, Ma JD. Observations on the urine metabolic profile of codeine in pain patients. Journal of Analytical Toxicology 2014; 38(2):86-91.

18. Luk S, Atayee RS, Ma JD, Best BM. Urinary diazepam metabolite distribution in a chronic pain population. Journal of Analytical Toxicology 2014; 38(3):135-142.

19. Tse SA, Atayee RS, Ma JD, Best BM. Factors affecting carisoprodol metabolism in pain patients using urinary excretion data. Journal of Analytical Toxicology 2014; 38(3):122-128.

20. Elder NM, Atayee RS, Best BM, Ma JD. Observations of urinary oxycodone and metabolite distributions in pain patients. Journal of Analytical Toxicology 2014; 38(3):129-134.

21. Ma JD, Horton JM, Hwang M, Atayee RS, Roeland EJ. A single center, retrospective analysis evaluating the utilization of the opioid risk tool in opioid-treated cancer patients. Journal of Pain and Palliative Care Pharmacotherapy 2014; 28(1):4-9.

22. Bordson SJ, Atayee RS, Ma JD, Best BM. Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using provider-reported medication lists and urine drug testing. Pain Medicine 2014; 15(3):355-363.

23. Moy KV, Ma JD, Morello CM, Atayee RS, Best BM. Monitoring oxycodone use in patients with chronic pain: analysis of oxycodone and metabolite excretion in saliva and urine. Journal of Opioid Management 2014; 10(1):47-56.

24. Yee DA, Hughes MM, Guo AY, Barakat NH, Tse SA, Ma JD, Best BM, Atayee RS. Observation of improved adherence with frequent urine drug testing in pain patients. Journal of Opioid Management 2014; 10(2): 111-118.

25. Liu JC, Ma JD, Morello CM, Atayee RS, Best BM. Naltrexone metabolism and concomitant drug concentrations in chronic pain patients. Journal of Analytical Toxicology 2014; 38(4):212- 217.

26. Cao JM, Ma JD, Morello CM, Atayee RS, Best BM. Observations on hydrocodone and its metabolites in oral fluid specimens of the pain population: comparison with urine. Journal of Opioid Management 2014; 10(34):177-186.

27. Ramey K, Ma JD, Best BM, Atayee RS, Morello CM. Variability in metabolism of imipramine and desipramine using urinary excretion data. Journal of Analytical Toxicology 2014; 38(6): 368-374.

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28. Mann LM, Atayee RS, Best BM, Morello CM, Ma JD. Urine specimen detection of zolpidem use in patients with pain. Journal of Analytical Toxicology 2014; 38(6):322-326.

29. Barakat NH, Atayee RS, Best BM, Ma JD. Urinary hydrocodone and metabolite distributions in pain patients. Journal of Analytical Toxicology 2014; 38(7):404-409.

30. Jiang JY, Best BM, Morello CM, Atayee RS, Ma JD. Evaluation of concomitant methylphenidate and opioid use in patients with chronic pain. Journal of Analytical Toxicology 2014; 38(7):421-426.

31. Masters JC, Harano DM, Greenberg HE, Tsunoda SM, Jang I-J, Ma JD. Limited sampling strategy of partial area-under-the-concentration-time-curves to estimate midazolam systemic clearance for cytochrome P450 3A phenotyping. Therapeutic Drug Monitoring 2015; 37(1):84- 89.

32. Bruggeman AR, Heavey SF, Ma JD, Revta C, Roeland, EJ. Lack of documentation of evidence-based prognostication in cancer patients by inpatient palliative care consultants. Journal of Palliative Medicine 2015; 18(4):382-385.

33. Lee KC, Hudmon KS, Ma JD, Kuo GM. Evaluation of a shared pharmacogenomics curriculum for pharmacy students. Pharmacogenomics 2015; 16(4):315-322.

34. Lin KJ, Ching A, Edmonds KP, Roeland EJ, Revta C, Ma JD, Atayee RS. Variable patterns of continuous morphine infusions at end of life. Journal of Palliative Medicine 2015; 18(9):786- 789.

35. Chang AT, Bertino JS Jr, Nafziger AN, Kashuba ADM, Turpault S, Lewis LD, Ma JD. S- warfarin limited sampling models to estimate area under the concentration versus time curve for cytochrome P450 2C9 baseline activity and following induction. Therapeutic Drug Monitoring 2016; 38(3):383-387.

36. Ma JD, Tran V, Chan C, Mitchell WM, Atayee RS. Retrospective analysis of pharmacist interventions in an ambulatory palliative care practice. Journal of Oncology Pharmacy Practice 2016; 22(6):757-765.

37. Roeland EJ, Ma JD, Nelson SH, Seibert T, Heavey S, Revta C, Gallivan A, Baracos VE. Weight loss versus muscle loss: re-evaluating inclusion criteria for future cancer cachexia interventional trials. Supportive Care in Cancer 2017; 25(2):365-369.

38. Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney CM, Roeland E. Advance care planning and palliative care integration for hematopoietic stem cell transplant patients. Journal of Oncology Practice 2017; 13(9):e721-e728.

39. Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney CM, Roeland E. Transfusion practices at end of life for hematopoietic stem cell transplant patients. Supportive Care in Cancer 2018; 26:1927-1931.

40. Yang J, Patel M, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Stoch SA, Bertino JS Jr, Nafziger AN, Ma JD. Midazolam single timepoint concentrations to estimate exposure and cytochrome P450 (CYP) 3A constitutive activity utilizing limited sampling strategy with a population pharmacokinetic approach. Journal of Clinical Pharmacology 2018; 58(9):1205-1213.

41. Lin S, Nikanjam M, Capparelli EV, Allegrini A, Pavone D, Yim D-S, Hammami MM, Bertino JS Jr, Nafziger AN, Park Y-S, Yin OQ, Ma JD. Evaluation of omeprazole limited sampling

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strategies to estimate constitutive cytochrome P450 2C19 activity in healthy adults. Therapeutic Drug Monitoring 2018; 40; 754-758.

42. Roeland EJ, Sera CJ, Ma JD. More opioids, more constipation? Evaluation of longitudinal total oral opioid consumption and self-reported constipation in patients with cancer. Submitted.

43. Yang J, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Stoch SA, Bertino JS Jr, Nafziger AN, Ma JD. Midazolam limited sampling strategy with a population pharmacokinetic approach to simultaneously estimate cytochrome P450 (CYP) 3A constitutive, inhibition, and induction/activation conditions in healthy adults. Submitted.

REVIEWS AND INVITED ARTICLES 1. Ma JD, Nafziger AN, Bertino JS, Jr. Genetic polymorphisms of cytochrome P450 enzymes and the effect on interindividual, pharmacokinetic variability in extensive metabolizers. Journal of Clinical Pharmacology 2004; 44:447-456.

2. Trivedi M, Budihardjo I, Loureiro K, Reid TR, Ma JD. Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer. Future Oncology 2008; 4:483-500.

3. Lee KC, Ma JD, Kuo GM. Pharmacogenomics: Bridging the gap between science and practice. Pharmacy Today. 2009; 15:36-48 and Journal of the American Pharmacists Association 2010; 50:e1-e17.

4. Ma JD, Tsunoda SM, Bertino JS Jr, Trivedi M, Beale KK, Nafziger AN. Evaluation of in vivo P-glycoprotein probes: A need for validation. Clinical Pharmacokinetics 2010; 49:223-237.

5. Wu JC, Beale KK, Ma JD. Evaluation of current and upcoming therapies in oral mucositis prevention. Future Oncology 2010; 6:1751-1770.

6. Ma JD, Lee KC, Kuo GM. HLA-B*5701 testing to predict abacavir hypersensitivity. Public Library of Science Currents: Evidence on Genomic Tests 2010; 2:RRN1203.

7. Kuo GM, Ma JD, Lee KC, Bourne PE. Telemedicine, genomics, and personalized medicine: synergies and challenges. Current Pharmacogenomics and Personalized Medicine 2011; 9:6- 13.

8. Nguyen CM, Mendes M, Tsunoda S, Ma JD. Interleukin-28B genotype testing to determine response to the combination of pegylated-interferon and ribavirin for the treatment of hepatitis C virus. Public Library of Science Currents: Evidence on Genomic Tests 2011; 3:RRN1207.

9. Nguyen CM, Mendes M, Ma JD. Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk. Public Library of Science Currents: Evidence on Genomic Tests 2011; 3:RRN1236.

10. Nangia JR, Ma JD, Nguyen CM, Mendes MAS, Trivedi MV. Denosumab for treatment of breast cancer bone metastases and beyond. Expert Opinion on Biological Therapy 2012; 12(4):491-501.

11. Ma JD, Lee KC, Kuo GM. Clinical application of pharmacogenomics. Journal of Pharmacy Practice 2012; 25(4):417-427.

12. Ma JD, Heavey SF, Revta C, Roeland EJ. Novel investigational biologics for the treatment of cancer cachexia. Expert Opinion on Biological Therapy 2014; 14(8):1113-1120.

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13. Chang A, Roeland EJ, Atayee RS, Revta C, Ma JD. Transmucosal immediate-release fentanyl for breakthrough cancer pain: opportunities and challenges for use in palliative care. Journal of Pain and Palliative Care Pharmacotherapy 2015; 29(3):247-260.

14. Lam LH, Pirrello RD, Ma JD. A case-based approach to integrating opioid pharmacokinetic and pharmacodynamics concepts in cancer pain management. Journal of Clinical Pharmacology 2016; 56(7):785-793.

15. Momper JD, Tsunoda SM, Ma JD. Evaluation of proposed in vivo probe substrates and inhibitors for phenotyping transporter activity in humans. Journal of Clinical Pharmacology 2016; 56(Supple7):S82-S98.

16. Bruggeman AR, Kamal AH, LeBlanc TW, Ma JD, Baracos VE, Roeland EJ. Cancer cachexia: beyond weight loss. Journal of Oncology Practice 2016; 12(11):1163-1171.

17. Ma JD, El-Jawahri AR, LeBlanc TW, Roeland EJ. Pain syndromes and management in adult hematopoietic stem cell transplantation. Hematology/Oncology Clinics of North America 2018; 32(3): 551-567.

18. Hagmann C, Cramer A, Kestenbaum A, Durazo C, Downey A, Russell M, Geluz J, Ma JD, Roeland EJ. Evidence-based palliative care approaches to non-pain physical symptom management in cancer patients. Seminars in Oncology Nursing. In press.

CASE REPORTS, LETTERS TO THE EDITOR, AND COMMENTARIES 1. Ma JD, Nafziger AN, Mylott W, Haughey DB, Rocci ML Jr, Bertino JS, Jr. Quantitative assessment of hepatic blood flow using intravenous indocyanine green. European Journal of Clinical Pharmacology 2008; 64:1133-1134. 2. Ma JD, Nafziger AN, Mylott W, Haughey DB, Rocci ML Jr, Bertino JS, Jr. Lack of effect of subject posture on intravenous midazolam clearance: implications for hepatic cytochrome P450 3A phenotyping. British Journal of Clinical Pharmacology 2009; 67:374-375. 3. Kuo GM, Ma JD, Lee KC, Halpert JR, Bourne PE, Ganiats TG, Taylor P. Institutional Profile: University of California San Diego Pharmacogenomics Education Program (PharmGenEd™): bridging the gap between science and practice. Pharmacogenomics 2011; 12(2):149-53. 4. Hansen PR, Ma JD, Atayee RS. Preliminary analysis of midlevel practitioners on pain and health-related quality of life and function for a palliative care service at a comprehensive cancer center. Journal of Palliative Medicine 2012; 15(4):388-389. 5. Ma JD, Nafziger AN, Bertino JS Jr. Validating phenotyping cocktails: more work needs to be done. Journal of Clinical Pharmacology 2012; 52(11):1772-1773. 6. Ma JD, Lee KC, Kuo GM. A massive open online course on pharmacogenomics – not just disruptive innovation, but a possible solution. Pharmacogenomics 2013; 14(10):1125-27. 7. Ma JD, Nafziger AN, Bertino JS Jr. Endogenous 4β-hydroxycholesterol to cholesterol ratio is not a validated biomarker for the assessment of CYP3A activity. Drug Metabolism and Disposition 2013; 41(11):1972. 8. Elder NM, Atayee RS, Best BM, Ma JD. Authors’ reply. Journal of Analytical Toxicology 2014; 38(7):463. 9. Elder NM, Atayee RS, Best BM, Ma JD. Response to urine drug testing for oxycodone and its metabolites as a tool for drug-drug interactions. Journal of Analytical Toxicology 2015; 39(1):80. 10. Langley-DeGroot M, Ma JD, Hirst J, Roeland EJ. Olanzapine in the treatment of refractory non-chemotherapy-induced nausea and vomiting: a case report and review of the literature. Journal of Pain and Palliative Care Pharmacotherapy 2015; 29:148-152. 11. Ma JD, Benn M, Nelson SH, Campillo A, Heavey SF, Cramer A, Revta C, Thornberry K, Roeland EJ. Exploring the definition of an informed health care proxy. Journal of Palliative Medicine 2016; 19:250-251.

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12. Kronenberg DG, Hagmann CH, Ma JD, Revta C, Armstrong J, Roeland EJ. The default dilemma: code status regardless of medical context. Journal of Palliative Medicine 2016; 19(11):1134. 13. Yau WH, Roeland EJ, Revta C, Ale-Ali A, Ma JD. Opioid and benzodiazepine relative use in breast cancer patients before, during, and after chemotherapy. Journal of Pain and Palliative Care Pharmacotherapy 2018; 32(1):27-29.

Complete List of Published Work in MyBibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46319048/?sort=date&direction=ascending

BOOK AND BOOK CHAPTERS 1. Kuo GM, Lee KC, Ma JD. Pharmacogenomics in Pharmacy Practice. In: Remington: The Science and Practice of Pharmacy, Beringer P, Marderosian AD, Felton L, Gelone S, Gennaro AR, Gupta PK, Hoover JE, Popovich NG, Reilly WJ, Hendrickson R, Eds. 22nd Edition, London, UK, Pharmaceutical Press. 2013; 2647-2657. 2. Ma JD, Lewis KE, Bertino JS Jr. Ethical, legal, and social issues associated with pharmacogenomics. In Textbook of Pharmacogenomics: An Introduction and Clinical Perspective, Bertino J, Kashuba A, Ma JD, Fuhr U, DeVane CL, Eds. 1st Edition, McGraw Hill, New York, NY. 2013; 47-54. 3. Textbook of Pharmacogenomics: An Introduction and Clinical Perspective, Bertino J, Kashuba A, Ma JD, Fuhr U, DeVane CL, Eds. 1st Edition, McGraw Hill, New York, NY. 2013; 288 p. 4. Huynh T, Backes AC, Lee KC, Ma JD, Kuo GM. Pharmacogenomics: advancing evidence- based personalized medicine. In: Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery, and Therapy. Vizirianakis I, Eds. 1st Edition, Pan Stanford Publishing, Singapore. 2014; 845-892. 5. Roeland E, Mitchell W, Mulroney C, Thornberry K, Atayee R, Ma J, Herman H. Symptom Control in Stem Cell Transplantation: a Multidisciplinary Palliative Care Team Approach. In: Textbook of Palliative Medicine and Supportive Care. Bruera, Higginson, von Gunten, Morita, eds. 2nd Edition, CRC Press, Boca Raton, FL. 2015. 6. Ma JD. Pharmacogenomics. In: RxPrep™ Course Book. A Comprehensive Course for the NAPLEX® & CPJE. Shapiro K, Brown SA, Eds. 2015 Edition; 134-142. 7. Lee KC, Ma JD, Kuo GM. Concepts in Pharmacogenomics and Personalized Medicine. In: Applying Pharmacogenomics in Therapeutics. Feng X, Xie H-G, Eds. CRC Press, Boca Raton, FL. 2016; 1-32. 8. Ma JD. Pharmacogenomics. In: RxPrep™ Course Book. A Comprehensive Course for the NAPLEX® & CPJE. Shapiro K, Brown SA, Garrett SD, Eds. 2016 Edition; 149-155.

PRESENTED ABSTRACTS 1. Del Rio JA, Helmy M, Golshani K, Than P, Yam C, Knoski S, Ma J, Stein L, Belluzzi JD. Dopamine D2 agonist self-administration: blockade by D1 or D2 receptor antagonists. Society for Neuroscience Abstracts 1997; 23:1104. 2. Del Rio JA, Knoski S, Helmy M, Ma J, Varghese R, Stein L, Belluzzi JD. Acquisition of cocaine and dopamine agonist self-administration in naive rats. Society for Neuroscience Abstracts 1998; 24:1483. 3. Ma, JD, Nafziger AN, Kashuba ADM, Rowland E, Gaedigk A, Kim JS, Kim MJ, Bertino JS, Jr. Use of limited sampling strategy (LSS) of S-warfarin (S-W) concentrations or warfarin (W) S/R ratios as a biomarker for CYP2C9 activity. Clinical Pharmacology & Therapeutics 2003; 73: P15. 4. Ma JD, Bertino JS, Jr, Gaedigk A, Kashuba ADM, Streetman DS, Nafziger AN. Inter- and intraindividual variability of urinary dextromethophan/dextrophan (DM/DX) ratios in CYP2D6 extensive metabolizers (EMs) with one or two active alleles. Clinical Pharmacology & Therapeutics 2004; 75: P18. 5. Ma JD, Nafziger AN, Villano SA, Gaedigk A, Victory J, Bertino JS, Jr. Effect of the anti- cytomegalovirus (CMV) drug maribavir (MB) on the activities of cytochrome P450 (CYP) 1A2, JD Ma Updated 05/18 Page 7

2C9, 2C19, 2D6, 3A, N-acetyltransferase-2 (NAT-2), and xanthine oxidase (XO) as assessed by the Cooperstown 5+1 drug cocktail. Clinical Pharmacology & Therapeutics 2005; 77: P19. 6. Ma JD, Nafziger AN, Villano SA, Victory J, Bertino JS, Jr. Single and multiple dose pharmacokinetics (PK) of maribavir (MB) in healthy adults. Clinical Pharmacology & Therapeutics 2005; 77: P19. 7. Ma JD, Nafziger AN, Mylott W, Haughey DB, Rocci ML, Bertino JS, Jr. Effects of posture (P) induced changes in hepatic blood flow (HBF) and plasma protein binding (PB) on the clearance (CL) of the intravenous (IV) cytochrome P450 3A (CYP3A) biomarker midazolam (MDZ). Clinical Pharmacology & Therapeutics 2005; 77: P33. 8. Ferbas J, Wallace DJ, Weisman MH, Belouski SS, Kesslak JP, Vincent M, Ma J, Zack D, Hendricks L, and Chung J. A systematic analysis of circulating B cell populations in healthy and SLE subjects. Annals of the Rheumatic Diseases 2006; 65(Suppl. II): 584. 9. Nguyen ET, Lee LS, Tsunoda SM, Greenberg HE, Ma JD. Oral midazolam limited sampling strategies (LSS) to predict cytochrome P450 (CYP) 3A inhibition. Clinical Pharmacology & Therapeutics 2010; 87: S23. 10. Ma JD, Ettouati WE. Design of a drug discovery, development, and commercialization elective course. American Journal of Pharmaceutical Education 2010; 74 (5): 23. 11. Ettouati WS, Ma JD. Development of a pharmaceutical and biotechnology industry mentorship program for pharmacy students. American Journal of Pharmaceutical Education 2010; 74 (5): 23. 12. Lawson EB, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim D-S, Yin OQP, Capparelli EV, Ma JD. Limitations of limited sampling strategy (LSS) for estimation of omeprazole (OME)-to-5-hydroxyomeprazole (5OH) area under the concentration time curve ratio (AUCOME/AUC5OH) in cytochrome P450 (CYP) 2C19 extensive metabolizers (EMs). Clinical Pharmacology & Therapeutics 2011; 89: S57. 13. Wu JC, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim D-S, Yin OQP, Capparelli EV, Ma JD. Limited sampling strategies (LSS) to predict omeprazole to omeprazole sulfone (OME/SULF) AUClast ratio as a biomarker of cytochrome P450 (CYP) 3A activity in CYP2C19 extensive meabolizers (EMs). Clinical Pharmacology & Therapeutics 2011; 89: S61. 14. McBane S, Painter NA, Lee KC, Ma JD, Bourne PE, Halpert JR, Taylor PW, Kuo GM. Bridging the gap between science and practice through the PharmGenEd™ program. American Journal of Pharmaceutical Education 2011; 75 (5): Article ajpe105. 15. Wu JC, Nafziger AN, Bertino JS, Jr., Ma JD. Truncated S-warfarin area under-under-curve (AUC) in cytochrome P450 (CYP) 2C9 extensive metabolizers is not predictive of AUC infinity in measuring CYP2C9 activity. Journal of Clinical Pharmacology 2011; 51:1326-1327. 16. Hoffman JT, Nguyen AN, Jang IJ, Kharasch ED, Ma JD. Evaluation of intravenous midazolam limited sampling strategies for prediction of area under the concentration-time curve during baseline cytochrome P450 3A conditions. Journal of Clinical Pharmacology 2011; 51:1334- 1335. 17. Nguyen AN, Hoffman JT, Tsunoda SM, Jang IJ, Kharasch ED, Ma JD. Evaluation of limited sampling strategies for prediction of intravenous midazolam exposure during cytochrome P450 inhibition and induction/activation. Journal of Clinical Pharmacology 2011; 51:1338. 18. Elder NM, Atayee RS, Ma JD, Best BM; Pesce AJ. Assessing Concomitant Use of Oxycodone Formulations with Known Strong Cytochrome P450 (CYP) 2D6 Inhibitors in Patients with Chronic Pain. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 19. Tse SA, Atayee RS, Ma JD, Best BM; Pesce AJ. Factors Which May Affect Carisoprodol Metabolism in Pain Patients Using Urinary Excretion Data. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 20. Guo AY, Atayee RS, Ma JD, Best BM; Pesce AJ. Inter- and Intra-subject Variability of Urinary Norbuprenorphine to Buprenorphine Metabolic Ratios in Pain Patients. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 21. Yee DA, Guo AY, Hughes MM, Tse SA, Barakat N, Atayee RS, Ma JD, Best BM; Pesce AJ. Observation of Improved Adherence with Ongoing Urine Drug Testing in Patients with Chronic Pain. Presented at PAINWeek 2011, Las Vegas, NV, September 2011.

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22. Yee DA, Atayee RS, Ma JD, Best BM; Pesce AJ. Observations on the Urinary Metabolic Profile of Codeine in Patients with Chronic Pain. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 23. Barakat NH, Atayee RS, Ma JD, Best BM; Pesce AJ. The Conversion of Hydrocodone to Hydromorphone and Norhydrocodone Comparison in Subjects with Chronic Pain. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 24. Luk SO, Atayee RS, Ma JD, Best BM; Pesce AJ. The Distribution of Diazepam Urinary Metabolites in a Sample of Patients with Chronic Pain. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 25. Moy KV, Atayee RS, Ma JD, Best BM; Pesce AJ. Variability of Meperidine Metabolism and Excretion in Urine. Presented at PAINWeek 2011, Las Vegas, NV, September 2011. 26. Gong SL, Tai W, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Stoch SA, Ma JD. Oral midazolam (MDZ) partial area-under curve (AUC) does not reliably predict cytochrome P450 (CYP) 3A inhibition and induction/activation in healthy subjects. Clinical Pharmacology & Therapeutics 2012; 91: S42-S43. 27. Tai W, Gong SL, Tsunoda SM, Greenberg HE, Gorski JC, Penzak SR, Stoch SA, Ma JD. Oral midazolam (MDZ) partial area-under curve (AUC) does not reliably predict cytochrome P450 (CYP) 3A baseline activity in healthy subjects. Clinical Pharmacology & Therapeutics 2012; 91: S42. 28. Luk SO, Atayee RS, Ma JD, Best BM, Pesce AJ. Effects of concomitant methadone and diazepam on urine specimens of patients with chronic pain. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 29. Luk SO, Atayee RS, Ma JD, Best BM, Pesce AJ. Effect of cytochrome P450 (CYP) 2C19 inhibitors on the distribution of urinary diazepam metabolites in patients with chronic pain. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 30. Guo AY, Atayee RS, Ma JD, Best BM, Pesce AJ. Concurrent non-prescribed and illicit drug use in patients prescribed buprenorphine. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 31. Yee DA, Atayee RS, Ma JD, Best BM, Pesce AJ. The effects of cytochrome P450 (CYP) 2D6 inhibitors on the metabolism of codeine to its active metabolites in patients with chronic pain. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 32. Bordson SJ, Atayee RS, Ma JD, Best BM, Pesce AJ. Factors affecting urinary excretion of amitriptyline in patients with neuropathic pain. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 33. Bordson SJ, Atayee RS, Ma JD, Best BM, Pesce AJ. Tricyclic antidepressants in the treatment of neuropathic pain: is your patient taking them? Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 34. Moy KV, Atayee RS, Ma JD, Best BM, Pesce AJ. Meperidine adherence and concomitant medication use in patients with chronic pain. Presented at the 2012 AAPM Annual Meeting, Palm Springs, CA, February 2012. 35. Win E, Morello CM, Ma JD, Best BM, Atayee RS, Pesce AJ. Observations of venlafaxine metabolism in urine specimens from patients with chronic pain. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 36. Yee DA, Best BM, Ma JD, Atayee RS, Pesce AJ. Use of the urinary morphine to codeine ratio analyzed using LC-MS/MS in the detection of heroin use in patients with pain. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 37. Mann LM, Ma JD, Best BM, Morello CM, Atayee RS, Pesce AJ. Concomitant opioid and sleep medication use in patients with pain. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 38. Saarikoski PH, Ma JD, Best BM, Morello CM, Atayee RS, Pesce AJ. Concomitant use of opioids and ketamine in patients with pain. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 39. Cao JM, Best BM, Ma JD, Morello CM, Atayee RS, Pesce AJ. Observations on hydrocodone and its metabolites in oral fluids of subjects with chronic pain: comparison with urine.

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Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 40. Jiang Y, Ma JD, Best BM, Morello CM, Atayee RS, Pesce AJ. Concomitant opioid and methylphenidate use in patients with chronic pain. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 41. Moy KV, Best BM, Ma JD, Morello CM, Atayee RS, Pesce AJ. Monitoring oxycodone use in patients with chronic pain: analysis of oxycodone and metabolite excretion in oral fluid and urine. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 42. Ramey K, Morello CM, Ma JD, Best BM, Atayee RS, Pesce AJ. Observations on the variability of metabolism of imipramine and desipramine in the treatment of neuropathic pain using urinary excretion data. Presented at PAINWeek: National Conference on Pain for Frontline Practitioners, Las Vegas, NV, September 2012. 43. Moy KV, Ma JD, Best BM, Morello CM, Atayee RS, Pesce AJ. Effect of sex and age on oxycodone metabolism in oral fluid in patients with chronic pain. Presented at 19th Annual Napa Pain Conference, Napa, CA, September 2012. 44. Liu JC, Best BM, Ma JD, Morello CM, Atayee RS, Pesce AJ. Naltrexone metabolism and concomitant drug concentrations in patients with chronic pain. Presented at 19th Annual Napa Pain Conference, Napa, CA, September 2012. 45. Harano DM, Masters JC, Greenberg HE, Tsunoda SM, Jang I-J, Ma JD. Intravenous midazolam partial area-under-the-curve as a biomarker to predict hepatic cytochrome P450 3A baseline activity in healthy adults. Clinical Pharmacology and Drug Development 2013; 2(S1): 26-27. 46. Masters JC, Harano DM, Greenberg HE, Tsunoda SM, Jang I-J, Ma JD. Utility of intravenous midazolam partial area-under-the-curve to predict hepatic cytochrome P450 3A activity during inhibition and induction. Clinical Pharmacology and Drug Development 2013; 2(S1): 26. 47. Ma JD, Horton JM, Hwang M, Atayee RA, Roeland E. A single center, retrospective analysis evaluating aberrant drug behavior stratification utilizing the opioid risk tool in cancer patients. Presented at the ASCO Quality Care Symposium, San Diego, November 2013. 48. Horton JM, Hwang M, Ma JD, Roeland E. A single center, retrospective chart review evaluating outpatient code status documentation in the EPIC electronic medical record for patients with advanced solid tumor cancer. Presented at the ASCO Quality Care Symposium, San Diego, CA, November 2013. 49. Roeland EJ, Heavey S, Revta C, Atayee RS, Ma JD, Benn M. Single center, prospective pilot study to evaluate advance care planning implementing the 3 questions and 3 elements to identify an informed health care proxy in an outpatient oncology palliative care clinic. (Abstract #130858). Presented at the 2014 ASCO Annual Meeting, Chicago, IL, June 2014. 50. Ma JD, Roeland EJ, Mitchell WM, Atayee RS. Patient outcomes of a pharmacist-physician collaboration in a palliative care outpatient practice. Presented at the 2014 MASCC/ISOO Annual Meeting, Miami, FL, June 2014. 51. Heavey SF, Benn MC, Revta C, Atayee RS, Ma JD, Roeland EJ. Single Center, Pilot Study to Evaluate a Novel Advance Care Planning Tool to Identify Informed Health Care Proxies in an Oncology Palliative Care Clinic. Presented at the 2014 MASCC/ISOO Annual Meeting, Miami, FL, June 2014. 52. Bruggeman A, Ma J, Heavey SF, Roeland E. Prevalence of Evidence-Based Prognostic Indicators for Inpatient Palliative Care Consult Notes at a Single Academic Medical Center. Presented at the 2014 MASCC/ISOO Annual Meeting, Miami, FL, June 2014. 53. Chang A, Bertino JS Jr., Nafziger AN, Kashuba ADM, Turpault S, Ma J. Evaluation of S- warfarin limited sampling models (LSMs) to estimate cytochrome P450 (CYP) 2C9 activity. Clinical Pharmacology and Drug Development 2014; 3(S1): 12-13. 54. Roeland E, Benn M, Heavey SF, Campillo A, Revta C, Atayee RS, Ma JD. Pilot Study to Evaluate a Novel Advance Care Planning Tool to Identify Informed Health Care Proxies in an Oncology Palliative Care Clinic. Journal of Clinical Oncology 2014; 32(S31): Abstract 136. 55. Lin KJ, Ching A, Revta C, Roeland EJ, Ma JD, Atayee RS. Titrate to death? Prescribing patterns of continuous morphine infusions at end of life. Journal of Pain and Symptom Management 2015; 49(2):437.

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56. Lam LH, Allegrini A, Hammami M, Kang J-S, Pavone D, Park Y-S, Yin OQ, Ma J. Evaluation of omeprazole limited sampling strategy (LSS) to estimate cytochrome (CYP) 2C19 activity in healthy adults. Clinical Pharmacology and Drug Development 2015; 4(S1): 26. 57. Roeland EJ, Nelson SH, Campillo A, Heavey SF, Ma JD, Revta C, Gallivan A, Baracos V. Inclusion criteria for cancer cachexia clinical trials: CT-defined skeletal muscle loss versus body weight loss. Journal of Clinical Oncology 2015; 33(29S): abstract 67. 58. Kronenberg D, Armstrong JM, Ma JD, Revta C, Roeland E. Code status documentation in the electronic medical record for Stage IV pancreatic cancer patients. Presented at ASCO Quality Care Symposium, Phoenix, AZ, February 2016. 59. Capparelli E, Chiswell K, Smith B, Siegel D, Weinstein S, Muchohi S, Reed M, Barrett J, deWildt S, Jaqc-Aigrain E, Ma J, Glauser T for the Pediatric Trials Network. Use of pediatric and adult midazolam population pharmacokinetics to assess IM dosing and early drug exposure for status epilepticus. Presented at Pediatric Academic Societies Meeting, Baltimore, MD, April-May 2016. 60. Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney CM, Roeland E. Blood transfusions at end-of-life for stem cell transplant patients. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Francisco, CA, September 2016. 61. Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney CM, Roeland E. Advance care planning and palliative care consultation for stem cell transplant patients. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Francisco, CA, September 2016. 62. Ma JD, Wang W, Yau W, Hagmann C, Revta C, Armstrong J, Roeland EJ. Molecular tumor profiling ordering trends in cancer patients. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Francisco, CA, September 2016. 63. Yau WH, Roeland EJ, Revta C, Ale-Ali A, Ma JD. Opioid and benzodiazepine use in breast cancer patients before, during, and after curative chemotherapy. Pharmacotherapy: Journal Hum Pharm Drug Ther 36.12 (2016): e259. 64. Dullea A, Hagmann C, Russell M, Cramer A, Cohen-Arazi Y, Roeland EJ, Ma JD. Palliative Care Pharmacists as Advocates to Conduct Advance Care Planning. Presented at ASCO Quality Care Symposium, Orlando, FL, March 2017. 65. Hagmann C, Ma JD, Cramer A, Russell M, Dullea A, Roeland E, Cohen-Arazi Y. Administration of the ASCO Pilot Pain Survey to Identify Patient Education Deficiencies in Cancer Patients. Presented at ASCO Quality Care Symposium, Orlando, FL, March 2017. 66. Ma JD, Hagmann C, Dullea A, Wang W, Yau W, Revta C, Armstrong J, Roeland EJ. Next- Generation Sequencing Ordering Trends in the Cancer Trajectory. Presented at ASCO Annual Meeting, Chicago, IL, June 2017. 67. Best BM, Yam FK, Ma JD, Adler DS. Promoting innovation and entrepreneurship in pharmacy students through required research projects. Presented at AACP Annual Meeting, Nashville, TN, July 2017. 68. Singh RF, Lee KC, Lorentz S, Ma J, Colbert J, Painter NA, Atayee R, Fricovsky E, Le J. An innovate process for systematic review of experiential courses and site visits. Presented at AACP Annual Meeting, Nashville, TN, July 2017. 69. Lin S, Nikanjam M, Capparelli E, Allegrini A, Pavone D, Yim DS, Hammami MM, Bertino Jr JS, Park YS, Kang JS, Yin OQ, Ma JD. Omeprazole limited sampling strategies to predict clearance: implications for cytochrome P450 2C19 phenotyping. Clinical Pharmacology in Drug Development 2017 6(S1):40-41. 70. Friedman S, Cardenas V, Nelson SH, Gabbai-Saldate P, Ng K, Cohen-Arazi Y, Ma JD, Martinez ME, Roeland EJ. Advance Care Planning in Hispanic/Latino and Non-Hispanic White Cancer Patients. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Diego, October 2017. 71. Roeland E, Ma JD, Binder G, Goldberg R, Paglia R, Knoth RL, Schwartzberg LS. Hospitalization Costs for Nausea and Vomiting: A Savings Opportunity. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Diego, October 2017. 72. Roeland E, Binder G, Ma JD, Lanzarotti C, Zhang L. Evaluation of daily breakthrough chemotherapy-induced nausea and vomiting (CINV) rates in a phase 3 study of NEPA versus

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an aprepitant (APR)/Granisetron (GRAN) regimen. Presented at ASCO Palliative and Supportive Care in Oncology Symposium, San Diego, October 2017. 73. Cardenas V, Friedman S, Nodora J, Nelson SH, Gabbai-Saldate P, Ng K, Cohen-Arazi Y, Ma JD, Martinez ME, Roeland EJ. One Size Does Not Fit All: Challenges in Advance Care Planning and End-of-Life Treatment Preferences by Latino and Non-Latino White Cancer Patients. Presented at American College of Psychopharmacology Annual Meeting, Palm Springs, December, 2017. 74. Roeland E, El-Jawahri A, Horick N, Nelson SH, Gallivan A, Nipp RC, Cohen-Arazi Y, Friedman S, Sera C, Ma J, Baracos VE, Patel SP, Phull H. CACHEXIO: Evaluation of Body Composition Changes & Immunotherapy in Patients with Metastatic Cancer. ASCO Palliative and Supportive Care in Oncology Symposium. Accepted for presentation. 75. Roeland E, El-Jawahri A, Nelson SH, Gallivan A, Nipp RC, Horick N, Cohen-Arazi Y, Hagmann C, Sera C, Friedman S, Ma J, Phull H, Baracos VE. FIT: Functional and Imaging Testing for Patients with Metastatic Cancer. Submitted to ASCO Palliative and Supportive Care in Oncology Symposium. 76. Sera CJ, Roeland EJ, Ma JD. More Opioids, More Constipation? Evaluation of Longitudinal Total Oral Opioid Consumption and Patient-Reported Constipation in Patients with Cancer. Submitted to ASCO Palliative and Supportive Care in Oncology Symposium. Accepted for presentation.

INVITED LECTURE PRESENTATIONS 1. Effects of D1 and D2 Receptor Selective Antagonists on Self-Administration of the D1 Agonist SKF-82958. Undergraduate Research Spring Seminar, Irvine, CA, May 1997. 2. California Pharmacy Board Exam Review. California Pharmacists' Association, Western Pharmacy Education Faire, Sacramento, CA, September, 2002. 3. Use of Limited Sampling Strategy (LSS) of S-Warfarin (S-W) Concentrations or Warfarin (W) S/R Ratios As A Biomarker For CYP2C9 Activity. Research Institute Grand Rounds, Bassett Healthcare, Cooperstown, NY, July 2003. 4. The Effect of Liver Blood Flow and Protein Binding on Midazolam Clearance. Prevalere Life Sciences, Whitesboro, NY, June 2004. 5. Academic Versus Industry Fellowships. What are the Differences? Amgen, Inc., Thousand Oaks, CA, June 2005. 6. Drug Metabolism – Emphasis on the Cytochrome P450 Enzymes. Amgen, Inc., Thousand Oaks, CA, August 2005. 7. Fellowships as an Option for Post Doctoral Training. American Association Pharmaceutical Scientists Student Committee, San Diego, CA, May 2008. 8. A Case Study in Oncology Drug Development: Time and Money. Biotech Demystified. The Science Behind the Business. UCSD SSPPS and Rady School of Management, San Diego, CA, June 2008. 9. A Case Study in Oncology Drug Development: Time and Money. Biotech Demystified. The Science Behind the Business. UCSD SSPPS and Rady School of Management, San Diego, CA, October 2008. 10. Pharmacogenomics Education (PharmGenEd) Program: Bridging the Gap between Science and Practice. American Pharmacists Association Annual Meeting and Exposition, San Antonio, TX, April 2009. 11. A CDC-supported Pharmacogenomics Education Program: Bridging the Gap between Sciences and Practice. American Association of Colleges of Pharmacy Annual Meeting and Seminars, Boston, MA, July 2009. 12. Pharmacogenomics Education (PharmGenEdTM) Program: Bridging the Gap between Science and Practice. San Diego Pharmacists Association and San Diego Society of Health System Pharmacists Continuing Education Seminar, San Diego, CA, July 2009. 13. What Pharmacists Need to Know About Pharmacogenomics. University of Michigan College of Pharmacy’s Tom D. Rowe 58th Annual Pharmacy Lecture, Ann Arbor, MI, October 2009. 14. Pharmacogenomics Education (PharmGenEdTM) Program: Bridging the Gap between Science and Practice. California Society of Health System Pharmacists Seminar Meeting, San Diego, CA, October 2009.

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15. Pharmacogenomics Education (PharmGenEdTM) Program: Bridging the Gap between Science and Practice. University of British Columbia, Vancouver, British Columbia, Canada, October 2009. 16. Next Steps…What to Do to Prepare for Residencies and Fellowships. 44th American Society of Health System Pharmacists Midyear Clinical Meeting and Exhibition, Las Vegas, NV, December 2009. 17. Meet the Experts. Pharmacogenomics Education (PharmGenEdTM) Program: Bridging the Gap between Science and Practice. 44th American Society of Health System Pharmacists Midyear Clinical Meeting and Exhibition, Las Vegas, NV, December 2009. 18. From Research to Clinical Practice: Evidence-Based Pharmacogenomic Recommendations. 44th American Society of Health System Pharmacists Midyear Clinical Meeting and Exhibition, Las Vegas, NV, December 2009. 19. Validity and Utility of Pharmacogenomic Tests and Their Potential Clinical Implications. Minnesota Pharmacists Association Midwinter Conference, Minneapolis, MN, January 2010. 20. Pharmacogenomics Education (PharmGenEdTM) Program: Bridging the Gap between Science and Practice. University of California, San Diego, San Diego, CA, February 2010. 21. Train the Trainer to Implement a National Pharmacogenomics Education Program to Bridge the Gap between Science and Practice. American College of Clinical Pharmacy Spring Forum, Charlotte, NC, April 2010. 22. Pharmacogenomics: What Pharmacists Need to Know. 126th Minnesota Pharmacists Association Annual Meeting and Conference. Nisswa, MN, June 2010. 23. What Pharmacists Need to Know about Pharmacogenomics. Orange County Society of Health System Pharmacists, Anaheim, CA, November 2010. 24. Fellowships for Pharmacy Students. UCSD, SSPPS, San Diego, CA, November 2010. 25. Fellowships: What Pharmacy Students Need to Know. 45th American Society of Health System Pharmacists Midyear Clinical Meeting and Exhibition, Anaheim, CA, December 2010. 26. Is a Fellowship Right for You? Western University of Health Sciences, College of Pharmacy, Pomona, CA, April 2011. 27. Personalized Medicine. Biotech Demystified. The Science Behind the Business. UCSD SSPPS and Rady School of Management, San Diego, CA, June 2011. 28. Pharmacogenomics Focused Forum: Education in Pharmacogenomics. California Society of Health System Pharmacists Seminar Meeting, Anaheim, CA, November 2011. 29. Drug Development, the Role of Regulatory Agencies, and Clinical Trials. Zhejiang Institute for Food and Drug Control Delegation. La Jolla, CA, November 2011. 30. Roadmap to Residencies and Fellowships. UCSD, SSPPS, San Diego, CA, July 2012. 31. Personalizing Pain Care with Pharmacogenetics: Case studies in medication monitoring, metabolites, and metabolism. PAINWeek, Las Vegas, NV, September 2012. 32. Opioid Pharmacokinetic Concepts. UC San Diego Clinical Geriatrics Interprofessional Symposium, La Jolla, CA, October 2014. 33. Drug Development, the Role of Regulatory Agencies, and Clinical Trials. Henan University School of Medicine. La Jolla, CA, December 2014. 34. Current Therapies and Investigational Agents for Cancer Cachexia. American College of Clinical Pharmacology Annual Meeting, San Francisco, CA, September 2015. 35. How to manage your medications. UC San Diego Center for Healthy Aging & Stein Institute for Research on Aging. La Jolla, CA, October 2015. 36. The Goldilocks Approach to Opioid Therapy - Not too Little, Not too Much, Just Right! UCSD SSPPS Preceptor Conference, La Jolla, CA, June 2016. 37. Managing your Medications Properly. University of San Diego’s University of the Third Age (U3A), San Diego, CA, June 2016.

TEACHING EXPERIENCE Didactic Lectures 1. SPPS201 Pharmacy Practice, Fever (1 hr), 2008-2012 2. SPPS203 Pharmacy Practice, Nausea and Vomiting (1 hr), 2008-2010 3. SPPS203 Pharmacy Practice, Assisting Patients with Quitting (1 hr), 2008-2009 4. SPPS212A Therapeutics, Drug Interactions (1 hr), 2012-Present JD Ma Updated 05/18 Page 13

5. SPPS212B Therapeutics, Principles of Cancer and Chemotherapy (1.5 hr), 2008-2011 6. SPPS212B Therapeutics, Colon Cancer (1.5 hr), Winter 2008 7. SPPS212B Therapeutics, Pain Management (2 hr), Winter 2008 8. SPPS219/PHARM235 Pharmacogenomics, An Introduction to Pharmacogenomics (1 hr), 2014-Present 9. SPPS219/PHARM235 Pharmacogenomics, Oncology Pharmacogenomics (2 hr), 2011- Present 10. SPPS219/PHARM235 Pharmacogenomics, Opioid Pharmacogenomics and Pain Management (1 hr), 2015-Present 11. SPPS219/PHARM235 Pharmacogenomics, Ethical, legal, and social issues in Pharmacogenomics (1 hr), 2015-Present 12. SPPS202A Concepts in Pharmacy Practice (1 hr), 2009-Present 13. SPPS208 Study Design, Designing Phase I and II Studies (1 hr), 2011-2012 14. SPPS273/BIOM267/PHARM210/MGT217250 Drug Discovery, Development, and Commercialization, Clinical Study Start-up Activities (1 hr), 2010-Present 15. SPPS273/BIOM267/PHARM210/MGT217250 Drug Discovery, Development, and Commercialization, Clinical Trials Phase I (1 hr), 2010-2012 16. UCSD Undergraduate Course, Journeys in Discovery: Drug Discovery, Patents & Biotech Startups, At the heart of biotechnology is scientific discovery. Innovation is the first to commercialization, (1 hr), Fall 2011 17. SPPS 288 Introduction to Clinical Oncology- The War on Cancer: From Beginning to End, Overview of palliative and hospice care (1 hr), Winter 2017 18. SPPS269, Pharmacotherapy of Pain Management, Adjuvant Analgesics (1 hr), 2014 19. SPPS265, Geriatric Pharmacotherapy (1 hr), 2014-Present 20. MED 296-005, Student-Senior Partners, Medication Management in the Older Adult, Spring 2013

Required Course Coordination 1. SPPS212B Therapeutics, Co-chair (80 hr), 2008-2010, 2012-2014 2. SPPS212A Therapeutics, Co-chair (80 hr), Fall 2010 3. SPPS219/PHARM235 Pharmacogenomics, Chair (40 hr), 2015-Present

Elective Course Coordination 1. SPPS273/BIOM267/PHARM210/MGT217250 Drug Discovery, Development, and Commercialization (50 hr), Co-chair, 2010-2018 2. SPPS265 Geriatric Pharmacotherapy, Co-chair, 2012-Present 3. SPPS198 Geriatrics Elective -Independent Student Project, Chair, 2009-2013 4. SPPS198 Scientific Writing Elective -Independent Student Project, Co-chair, Fall 2011 5. SPPS269 Pharmacotherapy of Pain Management, Co-chair, 2014

CONTRACTS AND GRANTS 1. Source: CDC, 1U38GD000070-01 Title: Pharmacogenomics education program: Bridging the gap between science and practice Time Period: September 2008 to September 2011 Amount: $1,047,991 Role: Co-Investigator (20% effort), Program Associate (PI: Kuo) Status: Funded and Complete

2. Source: UCSD, Academic Geriatric Resource Center (AGRC) Title: Expansion of Pharmacy Student-Initiated Education Programs for the Geriatric Population Time Period: October 2009 to September 2010 Amount: $2000 Role: Principal Investigator/Faculty Mentor Status: Funded and Complete JD Ma Updated 05/18 Page 14

3. Source: UCSD, Academic Geriatric Resource Center (AGRC) Title: Pharmacy Student-Outreach Handout Preparation Time Period: February 2011 to June 2011 Amount: $1200 Role: Principal Investigator/Faculty Mentor Status: Funded and Complete

4. Source: Millennium Research Institute Title: Urinary Excretion Pharmacokinetics of Pain Medications – Student Pharmacists Research Projects Time Period: June 2011 to July 2012 Amount: $75,000 Role: Co-Investigator (PI: Best) Status: Funded and Complete

5. Source: UCSD, Academic Geriatric Resource Center (AGRC) Title: Pharmacy Student-Initiated Education Programs Time Period: July 2011 to June 2012 Amount: $3510 (2.5% support) Role: Principal Investigator/Faculty Mentor Status: Funded and Complete

6. Source: Millennium Laboratories, Inc. Title: Pain Medications and Pharmacogenomics – Speaker Programs & Training Time Period: October 2011 - 2014 Amount: $136,750 Role: Paid Consultant, Advisory Board Member Status: Funded and Complete

7. Source: Millennium Research Institute Title: Urinary Excretion Pharmacokinetics of Pain Medications – Student Pharmacists Research Projects Time Period: June 2012 – July 2013 Amount: $85,000 Role: Principal Investigator Status: Funded and Complete

8. Source: Astra Zeneca, Inc. Title: Phase II, Randomized, Single-Center, Pilot Feasibility Study to Evaluate Naloxegol for Opioid-Induced Constipation in Cancer Patients (IND 130306, NCT02745353 Time Period: January 2016- March 2018 Amount: $276,106 Role: Co Investigator (PI: Roeland) Status: Funded and complete

CLINICAL SERVICE 2002 – 2004 Clinical Pharmacist, Clinical Pharmacology Inpatient Consult Service, Bassett Healthcare, Cooperstown, NY 2004 – 2007 Clinical Trial Specialist, Amgen, Inc., Early Development, Thousand Oaks, CA 2004 – 2007 Staff Pharmacist, Pavilions Pharmacy, Westlake, CA 2008 – 2010 Pharmacist, UCSD Student-Run Free Clinic, San Diego, CA 2010 – Present Pain and Palliative Care Clinical Pharmacist, Doris A. Howell Consult Service, UCSD Moores Cancer Center

JD Ma Updated 05/18 Page 15

UNIVERSITY SERVICE 1. Member, UCSD SSPPS Committee on Educational Policy (CEP), 2007-present 2. Member, UCSD SSPPS Educational Policy and Academic Oversight committee (EPOAC), 2007-present 3. Member, Ad hoc UCSD SSPPS PharmD Graduation Research Project Committee, 2008 4. Member, UCSD SSPPS/Pfizer Clinical Oncology Fellowship Program Committee, 2009- present 5. Member, Ad hoc UCSD SSPPS 4th year APPE Spring Block Planning Committee, 2009 6. Faculty Co-Advisor. American Society of Consultant Pharmacists (ASCP) – UCSD SSPPS Student Chapter San Diego, CA. 2008-present 7. Co-Chair, SSPPS Pharmaceutical/Biotech Industry Mentor Program, 2009–2010 8. Member, UCSD SSPPS Cardiology Faculty Search Committee, 2010-2011 9. Member, UCSD SSPPS Associate Dean for Student Affairs Search Committee, 2011 10. Member, UCSD SSPPS Nigeria APPE Committee, 2011-2012 11. Member, UCSD Academic Oversight Committee (AOC), 2011-Present 12. Member, Ad hoc UCSD SSPPS Residency Preparation Committee, 2012-Present 13. Member, UCSD SSPPS APPE/IPPE Course Committee (SAICC), 2012-Present 14. Director, UCSD SSPPS Summer Research Program, 2013-Present

COMMUNITY AND PUBLIC SERVICE 1. Pharmacist Representative. UCSD Doc For A Day Program. San Diego, CA, 2008. 2. Faculty Participant. UCSD SSPPS and China Medical University Collaboration. San Diego, CA, February 2008. 3. Career Roundtable Speaker. 3rd Annual CPhA Student Pharmacist and New Practitioner's Summit. San Diego, CA, April 2008. 4. Faculty Preceptor, ASCP Community Outreach Presentation, Common Cold, Ocean Hills County Club, Oceanside, CA, May 2009. 5. Faculty Preceptor, ASCP Community Poster Health Fair, Horton House, San Diego, CA, August 2009. 6. Faculty Preceptor, ASCP Community Poster Presentation, Anemia and Constipation, Redwood Villa, San Diego, CA, November 2009. 7. Guest, XM Radio ReachMD, Diabetes Discourse, How will Pharmacogenomics Play a Role in Diabetes Therapy? San Diego, CA, December 2009. Available at: http://reachmd.com/xmsegment.aspx?sid=4879. 8. Faculty Preceptor, ASCP Community Outreach Presentation, Asthma and COPD, Brookview Village, Poway, CA, February 2010. 9. Faculty Preceptor, ASCP Community Outreach Presentation, Peptic Ulcer Disease, Classic Residency Senior Center, La Jolla, CA, March 2010. 10. Faculty Preceptor, ASCP Community Outreach Presentation, Thyroid Disease, Classic Residency Senior Center, La Jolla, CA, March 2010. 11. Faculty Preceptor, ASCP Community Outreach Presentation, Diabetes, Classic Residency Senior Center, La Jolla, CA, May 2010. 12. Faculty Preceptor, ASCP Community Outreach Presentation, Erectile Dysfunction & BPH, Classic Residency Senior Center, La Jolla, CA, May 2010. 13. Faculty Preceptor, ASCP Community Outreach Presentation, Diabetes, Brookview Village, Poway, CA, June 2010. 14. Faculty Preceptor, ASCP Community Outreach Presentation, Vaccinations, Del Mar City Hall, Del Mar, CA, July 2010. 15. Faculty Preceptor, ASCP Community Outreach Presentation, Vaccinations, Fredricka Manor Care Center, Chula Vista, CA, August 2010. 16. Faculty Preceptor, ASCP Community Outreach Presentation, Hypertension, Redwood Villa, San Diego, CA, May 2011. 17. Faculty Preceptor, ASCP Community Outreach Presentation, Osteoporosis, Coronado Senior Housing, Coronado, CA, May 2011. 18. Faculty Preceptor, ASCP Meet the Pharmacist, Kimball Senior Center, National City, CA, September 2011. JD Ma Updated 05/18 Page 16

19. Faculty Preceptor, ASCP Community Outreach Presentation, Insomnia, Redwood Villa, San Diego, CA, May 2012. 20. Faculty Preceptor, ASCP Community Outreach Presentation, Cholesterol, Coronado Senior Housing, Coronado, CA, May 2012. 21. Faculty Preceptor, ASCP Community Outreach Presentation, Medication Use Safety Training, White Sands La Jolla, San Diego, CA, May 2013. 22. Faculty Preceptor, ASCP Community Outreach Presentation, Nutrition, La Vida Del Mar, Solana Beach, May 2013. 23. Faculty Preceptor, ASCP Community Outreach Presentation, Medicare Part D and Nutrition, Jewish Family Service of San Diego, San Diego, October 2014. 24. Faculty Preceptor, ASCP Community Outreach Presentation, Fall Prevention for the Older Adult, Brookview Village, Poway, CA, November 2015. 25. Faculty Preceptor, ASCP Community Outreach, Point of Care Cholesterol and Glucose Screenings, Temple Emanu-El, San Diego, CA, November 2016. 26. Faculty Preceptor, ASCP Community Outreach Presentation, Hypertension, Vi at La Jolla Village , La Jolla, CA, February 2017. 27. Faculty Preceptor, ASCP Community Outreach Presentation, Fall Prevention for the Older Adult, Vi at La Jolla Village , La Jolla, CA, September 2017. 28. Faculty Preceptor, ASCP Community Outreach Presentation, Osteoporosis, Brookview Village, Poway, CA, February 2018.

PHARMACY RESIDENT, FELLOW, AND STUDENTS TRAINEES Post-graduate (PGY) pharmacy residents (Role: Pharmacist clinical preceptor) 1. Alicia Cymbala, PharmD, PGY1 acute care, Bassett Healthcare, 2002-2003 2. Constance Law, PharmD, PGY1 acute care, Bassett Healthcare, 2002-2003 3. Tracy Keller, PharmD, PGY1 acute care, Basset Healthcare, 2003-2004 4. Maylee Chen, PharmD, PGY1 acute care, Bassett Healthcare, 2003-2004 5. Christine M. Nguyen, PharmD, PGY2, VA San Diego, 2010-2011 6. Sandra Chiang, PharmD, PGY2 ambulatory care, UCSD, 2011 7. Lucas Hills, PharmD, PGY1 ambulatory care, UCSD, 2011 8. Esther Wee, PharmD, PGY2 oncology, UCSD, 2011 9. Mark Mariski, PharmD, PGY1 ambulatory care, UCSD, 2011 10. Jane Liou, PharmD, PGY1 ambulatory care, UCSD, 2012 11. Priya Amin, PharmD, PGY1 ambulatory care, UCSD, 2012 12. Noah Nevo, PharmD, PGY1 ambulatory care, UCSD, 2013 13. Annie Shanton, PharmD, PGY1 ambulatory care, UCSD, 2013 14. Jesse Wisniewski, PharmD, PGY1 ambulatory care, UCSD, 2013 15. Janine Galasso, PharmD, PGY2 oncology, UCSD, 2013 16. Cathy Thach, PharmD, PGY1 ambulatory care, UCSD, 2014 17. Angela Crispo, PharmD, PGY2 psychiatry, UCSD, 2014 18. Ozioma (Peace) Uche, PharmD, PGY1 ambulatory care, UCSD, 2014 19. Melissa Cotterman, PharmD, PGY1 ambulatory care, UCSD, 2014 20. Carissa Chan, PharmD, PGY2 oncology, UCSD, 2014 21. Faaiza Alibhai, PharmD, PGY1 ambulatory care, UCSD, 2014-2015 22. Natalie Halanski, PharmD, PGY1 ambulatory care, UCSD, 2015 23. Mary Margaret Kwong, PharmD, UCSD, PGY1 ambulatory care, 2015 24. Carol Yacoub, PharmD, PGY2 oncology, UCSD, 2015 25. Maitri Patel, PharmD, PGY1 ambulatory care, UCSD 2016 26. Sandy Sallam, PharmD, PGY1 ambulatory care, UCSD 2016 27. Elizabeth Vuong, PharmD, PGY1 ambulatory care, UCSD 2016 28. Ronnie Delmonte, PharmD, PGY1 ambulatory care, UCSD 2016 29. Jessica Sexton, PharmD, PGY2 oncology, UCSD, 2016 30. Julie Savelloni, PharmD, PGY1 ambulatory care, UCSD 2017 31. Andrew Sam, PharmD, PGY2 oncology, UCSD 2017 32. Iris Chen, PGY1 ambulatory care, UCSD 2018

JD Ma Updated 05/18 Page 17

Post-doctoral clinical pharmacology/oncology pharmacy fellows (Role: Clinical research mentor) 1. Jerry Wu, PharmD, UCSD SSPPS/Pfizer, 2009-2011 2. Eileen Brigid Lawson, PharmD, UCSD SSPPS/Pfizer, 2009-2011 3. Justin Hoffman, PharmD, UCSD SSPPS/Pfizer, 2010-2012 4. Anh Nguyen, PharmD, UCSD SSPPS/Pfizer, 2010-2012 5. Joanna Cole Masters, PharmD, UCSD SSPPS/Pfizer, 2012-2013 6. Andy Chang, PharmD, PhD, UCSD SSPPS/Pfizer, 2013-2015 7. Lisa Lam, PharmD, UCSD SSPPS/Pfizer, 2014-2016 8. Maulik Patel, PharmD, PhD, UCSD SSPPS/Pfizer, 2015-2017 9. Swan Lin, PharmD, UCSD SSPPS/Pfizer, 2016-2017 10. Jin Yang, PharmD, UCSD SSPPS/Pfizer, 2017-Present 11. Jerry Li, PharmD, UCSD SSPPS/Pfizer, 2018-Present

Doctor of Pharmacy Students (Role: Advanced Pharmacy Practice Experience [APPE] preceptor) 1. Rina Patel, Class of 2012 2. Paul Ko, Class of 2012 3. Melissa Neighbors, Class of 2012 4. Jacqueline Hovhanessian, Class of 2012 5. Inna Sosinsky, Class of 2012 6. Uzra Wahid, Class of 2013 7. Albertino Tran, Class of 2013 8. Jack Yeung, Class of 2013 9. Lyn Nguyen, Class of 2013 10. Clara Yuan, Class of 2013 11. Tiffany Lew, Class of 2014 12. Katie Moy, Class of 2014 13. Jennifer Hao, Class of 2014 14. Joy Jiang, Class of 2014 15. Rebecca Wittenberg, Class of 2014 16. Pamela Saarikoski, Class of 2014 17. Thuy Nguyen, Class of 2015 18. Victor Tran, Class of 2015 19. Xuan Phan, Class of 2015 20. Tiffany Hsu, Class of 2015 21. Kara Kubli, Class of 2015 22. Kellie Kocher, Class of 2015 23. Patricia Smole, Class of 2016 24. Taylor Rotunno, Class of 2016 25. Linh Ngo, Class of 2016 26. Megan Won, Class of 2017 27. Brittany Belmer, Class of 2017 28. Tuan Phan, Class of 2017 29. Lindsay Ditmars, Class of 2017 30. Saif Namiq, Class of 2017 31. Kimberly San Agustin, Class of 2018 32. Jeremy Lai, Class of 2018 33. Erin Lee, Class of 2018 34. Tiffany Cheng, Class of 2018 35. Amber Naumann, Class of 2019 36. Andrew U, Class of 2019

Doctor of Medicine Candidates (Role: Pharmacist clinical preceptor) 1. Michael Langley-DeGroot, Class of 2015 2. Elizabeth Griffiths, Class of 2015 3. Ashlin Mounjoy, Class of 2015 JD Ma Updated 05/18 Page 18

4. Rashmi Manjunath, Class of 2015 5. Andrew Wei, Class of 2016

PROFESSIONAL COMMITTEES 1. Member, Meeting Program Committee, American College of Clinical Pharmacology 38th Annual Meeting, San Antonio, TX, September 2009. 2. Symposium Co-chair, Innovations and Controversies in Quantifying Drug-Drug Interactions, American College of Clinical Pharmacology 38th Annual Meeting, San Antonio, TX, September 2009. 3. Abstract Reviewer, American College of Clinical Pharmacology 38th Annual Meeting, San Antonio, TX, September 2009. 4. Member, White Paper Subcommittee, Education Position Paper, American College of Clinical Pharmacology, 2009. 5. Member, Strategic Visions Committee, American College of Clinical Pharmacology, 2010. 6. Abstract Reviewer, American College of Clinical Pharmacology 41st Annual Meeting, San Diego, CA, September 2012. 7. Symposium Co-chair, Chronic Pain: Underdiagnosed, undertreated, and misunderstood, American College of Clinical Pharmacology 41st Annual Meeting, San Diego, CA, September 2012. 8. Co-chair, Meeting Program Committee, American College of Clinical Pharmacology 41st Annual Meeting, San Diego, CA, September 2012. 9. Symposium Co-chair, Current and emerging therapies for the treatment of cancer cachexia, American College of Clinical Pharmacology 44th Annual Meeting, San Francisco, CA, September 2015. 10. Abstract Reviewer, American College of Clinical Pharmacology 46st Annual Meeting, San Diego, CA, September 2012. 11. Member, Education Committee, American College of Clinical Pharmacology, 2015-Present.

PROFESSIONAL AFFILIATIONS 2002 – 2013 American Society for Clinical Pharmacology and Therapeutics 2007 – Present American College of Clinical Pharmacology (ACCP) 2007 – 2012 American Association of Colleges of Pharmacy (AACP) 2010 – Present American College of Clinical Pharmacy (ACCP)

AD HOC JOURNAL REVIEWER 2008 – Present Clinical Therapeutics, Journal of Clinical Pharmacology 2010 – Present The Journal of Pharmacy Technology, Annals of Pharmacotherapy 2011 Book Proposal Reviewer for “Essentials of Pharmacogenomics”, John Wiley & Sons Publisher 2012 – Present Personalized Medicine, Pharmacogenomics, Journal of Palliative Medicine, European Journal of Clinical Pharmacology 2013 – Present Pharmacogenomics and Personalized Medicine, International Journal of Clinical Pharmacology & Therapeutics, Clinical Pharmacokinetics 2014 – Present Journal of Opioid Management, Journal of Clinical Psychopharmacology

HONORS & AWARDS 1. Recipient, National Institute on Drug Abuse (NIDA) Intramural Research Training Award, NIH, 1997 2. Recipient, National Institute on Drug Abuse (NIDA) Intramural Research Training Award, NIH, 1998 3. Recipient, 1998-1999 Rite Aid Scholarship 4. Recipient, 1999-2000 Bill Bacon Memorial Award 5. Finalist, UCSF Associated Students-School of Pharmacy 2000-2001 Student of the Year 6. Recipient, 2001 Julian Weiss Scholarship JD Ma Updated 05/18 Page 19

7. Finalist, 2002 UCSF School of Pharmacy Bowl of Hygeia Award 8. Recipient, National Center of Leadership in Academic Medicine, UCSD School of Medicine, 2008 9. Recipient, Excellence in Teaching Award 2007-2008, UCSD SSPPS Class of 2009 10. Recipient, Excellence in Teaching Award 2012-2013, UCSD SSPPS Class of 2014 11. Recipient, Fellow in Clinical Pharmacology, American College of Clinical Pharmacology, 2015 12. Recipient, Excellence in Achievement, American College of Clinical Pharmacology, 2016 13. Recipient, Faculty of the Year 2016-2017, UCSD SSPPS Class of 2018

JD Ma Updated 05/18 Page 20 OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Nemati, Shamim eRA COMMONS USER NAME (credential, e.g., agency login): snemati POSITION TITLE: Assistant Professor of Biomedical Informatics EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE END DATE FIELD OF STUDY (if applicable) MM/YYYY University of Oklahoma, Normal, OK BA 07/2005 Mathematics University of Oklahoma, Norman, OK MS 05/2007 Applied Mathematics Massachusetts Institute of Technology, Electrical Engineering and PHD 12/2012 Cambridge, MA Computer Science Postdoctoral Computer Science/Machine Harvard University, Cambridge, MA 12/2014 Fellow Learning

A. Personal Statement

A central theme of my research is the development of mathematical and computational tools that enable a mechanistic understanding of complex diseases, and allow for a data-driven approach to phenotyping of patients, tracking patients' trajectory, predicting impending events, and optimizing treatment strategies to avoid/mitigate adverse outcomes. To accomplish these, my research brings together concepts and tools across signal processing, information theory, control theory, optimization, and machine learning/deep learning to design physiologically-informed models and predictive analytic algorithms. A major focus of my current research has been in the intensive care unit (ICU) where I am developing interpretable ("transparent") machine learning algorithms capable of meaningfully summarizing large volumes of continuously measured patient data, with the goal of timely prediction of potentially life threatening clinical events and early risk assessment.

I have the necessary training to carry out the mathematical modeling, signal processing, and data analysis aspects of the proposed research project. I completed my Ph.D. degree in Electrical Engineering and Computer Science at the Massachusetts Institute of Technology in 2012. At MIT, I was a member of the Laboratory for Computational Physiology and Clinical Inference, and the Laboratory for Computational Physiology; home to the MIMIC-II ICU database and the PhysioNet (two of the earliest NIH-funded big data initiatives). While at MIT, I also held a National Research Service Award (NRSA) fellowship position at the Brigham and Women's Hospital and the Harvard Medical School where my work resulted in a number of advanced computational tools for phenotyping sleep apneic patients. As a James S. McDonnell fellow in Complex Systems, at the Harvard Intelligent Probabilistic Systems group, I obtained two years of postdoctoral training in Machine Learning/Deep Learning. In 2016, I was awarded a five year Mentored Career Development Award in biomedical big data science (K01) to support my training and research in intensive care unit (ICU) analytics, with a focus on the early prediction of Sepsis. Additionally, I'm currently the lead PI on a multi-center (BARDA-funded) study that involves retrospective validation of a sepsis prediction algorithm that was developed as a part of my K01 award, as well as a prospective implementation study of the associated software platform.

In summary, I believe my training in mathematical and engineering education as well as my position as an Assistant Professor of Biomedical Informatics, within the Emory School of Medicine, uniquely positions me to carry out the specific research aims of this proposal.

1. Nemati S, Holder A, Razmi F, Stanley MD, Clifford GD, Buchman TG. An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU. Crit Care Med. 2018 Apr;46(4):547- 553. PubMed PMID: 29286945; PubMed Central PMCID: PMC5851825. 2. Shashikumar SP, Li Q, Clifford GD, Nemati S. Multiscale network representation of physiological time series for early prediction of sepsis. Physiol Meas. 2017 Nov 30;38(12):2235-2248. PubMed PMID: 29091053; PubMed Central PMCID: PMC5736369. 3. Shashikumar SP, Stanley MD, Sadiq I, Li Q, Holder A, Clifford GD, Nemati S. Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics. J Electrocardiol. 2017 Nov - Dec;50(6):739-743. PubMed PMID: 28916175; PubMed Central PMCID: PMC5696025. 4. Nemati S, Ghassemi MM, Clifford G. Optimal Medication Dosing from Suboptimal Clinical Examples: A Deep Reinforcement Learning Approach. Engineering in Medicine and Biology Society (EMBC); 2016 August 24; Orlando, Florida, USA. B. Positions and Honors Positions and Employment 2004 - 2005 Research Assistant, Weather Radar Laboratory, University of Oklahoma, Norman, OK 2005 - 2007 Research Assistant, Symbiotic Computing Laboratory, University of Oklahoma, Norman, OK 2009 - 2012 NRSA Research Fellow, Brigham and Women's Hospital & Harvard Medical School, Boston, MA 2009 - 2012 PhD Candidate/Research Assistant, Massachusetts Institute of Technology, Cambridge, MA 2013 - 2014 James S. McDonnell Postdoctoral Fellow, Harvard School of Engineering and Applied Sciences, Cambridge, MA 2015 - 2019 Assistant Professor of Biomedical Informatics, Emory University, Atlanta, GA 2016 - 2019 Associate Assistant Professor, Mathematics & Computer Science, Emory University, Atlanta, GA 2019 - Assistant Professor of Biomedical Informatics, UC San Diego, San Diego, CA

Other Experience and Professional Memberships 2005 - Member, Institute of Electrical and Electronics Engineers (IEEE) 2006 - Member, Phi Beta Kappa Honor Society 2017 - Member, International Society for Computerized Electrocardiology (ISCE)

Honors 2005 First Place in IEEE Region 5 student paper contest, IEEE 2005 Outstanding Junior award, University of Oklahoma, School of Electrical and Computer Engineering 2007 Recipient of Harold Huneke Graduate Assistant Teaching Award, University of Oklahoma, Department of Mathematics 2009 Recipient of Ruth L. Kirschstein National Research Service Award (NRSA), Harvard Medical School 2013 Recipient of James S. McDonnell Postdoctoral Fellowship in Studying Complex Systems, James S. McDonnell Foundation 2015 Recipient of BD2K Early Career Award (K01), NIH 2016 Selected among the top 2% faculty, Emory University School of Medicine 2018 Selected among the top 2% faculty, Emory University School of Medicine

C. Contribution to Science 1. Intensive Care Unit (ICU) Analytics and Deep Learning: During my postdoctoral training I developed a novel machine learning algorithm for automatic discovery of a collection of ‘phenotypic’ dynamical patterns in a database of patient time series. These dynamics, which capture the directional couplings among the vitals signs, can be then correlated with short-term (onset of hypotension, positive blood culture, and sepsis) and long-term (survival vs. mortality) outcomes, arriving at a notion of ‘healthy’ and ‘unhealthy’ dynamics. To accomplish this, we showed it is possible to transform a switching state-space model of the underlying physiology (and more generally, any dynamic Bayesian network) to an equivalent deep recurrent neural network architecture for pattern recognition. This approach has two main advantages. First, it allows for a ‘model-based’ (as apposed to ‘black-box’) approach to pattern discovery in multivariate physiological time series. Second, it enables a principled approach for guiding medical interventions to restore healthy dynamics via application of Optimal Control methodologies.

This work attracted considerable attention from the machine learning and statistics communities (including invited talks and publications at the Neural Information Processing conference or NIPS, and the IEEE engineering in medicine and biology conference). Additionally, I am currently working with the Emory Critical Care Center (in collaborations with Excel Medical and IBM clinical analytics) to implement my predictive algorithms in real-time. The ultimate goal of this research is to change the current standard of care by guiding interventional strategies based on data-driven severity of illness scores, and model-based assessment of mechanisms underlying physiological deterioration.

a. Nemati S, Ghassemi MM, Clifford G. Optimal Medication Dosing from Suboptimal Clinical Examples: A Deep Reinforcement Learning Approach. Engineering in Medicine and Biology Society (EMBC); 2016 August 24; Orlando, Florida, USA. b. Lehman LW, Adams RP, Mayaud L, Moody GB, Malhotra A, Mark RG, Nemati S. A physiological time series dynamics-based approach to patient monitoring and outcome prediction. IEEE J Biomed Health Inform. 2015 May;19(3):1068-76. PubMed PMID: 25014976; PubMed Central PMCID: PMC4346516. c. Nemati S, Lehman LW, Adams RP. Learning outcome-discriminative dynamics in multivariate physiological cohort time series. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:7104-7. PubMed PMID: 24111382. d. Nemati S, Lehman LW, Adams RP, Malhotra A. Discovering shared cardiovascular dynamics within a patient cohort. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6526-9. PubMed PMID: 23367424; PubMed Central PMCID: PMC3821961.

2. Respiratory Control System Modeling: During my doctoral work, I developed a number of machine learning and control theoretic techniques for a data-driven approach to phenotyping patients with sleep-disordered breathing. My techniques are currently being tested in a clinical setting (at the Brigham and women's hospital) for phenotyping sleep apneic patients. As noted by the Journal of Applied Physiology editorial on my work, the ability to assess respiratory instability may prove clinically relevant to patients with panic disorder breathing, restrictive lung disease, and evaluation of weaning from mechanical ventilation in critically ill patients.

My work served as an inspiration for a 2014 Harvard Radcliffe Exploratory Seminar, titled "Moving from Reaction to Prediction: Leveraging High Speed Data Recording and Advanced Computational Tools for Prediction Sedation-Related Adverse Events in Children," where I spoke about application of machine learning and data-driven techniques to predictive monitoring of children in emergency rooms.

a. Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. J Appl Physiol (1985). 2011 Jul;111(1):55-67. PubMed PMID: 21474696; PubMed Central PMCID: PMC3137535. b. Wellman A, Edwards BA, Sands SA, Owens RL, Nemati S, Butler J, Passaglia CL, Jackson AC, Malhotra A, White DP. A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. J Appl Physiol (1985). 2013 Apr;114(7):911-22. PubMed PMID: 23349453; PubMed Central PMCID: PMC3633440. c. Gederi E, Nemati S, Edwards BA, Clifford GD, Malhotra A, Wellman A. Model-based estimation of loop gain using spontaneous breathing: a validation study. Respir Physiol Neurobiol. 2014 Sep 15;201:84-92. PubMed PMID: 25038522; PubMed Central PMCID: PMC4324174. d. Terrill PI, Edwards BA, Nemati S, Butler JP, Owens RL, Eckert DJ, White DP, Malhotra A, Wellman A, Sands SA. Quantifying the ventilatory control contribution to sleep apnoea using polysomnography. Eur Respir J. 2015 Feb;45(2):408-18. PubMed PMID: 25323235; PubMed Central PMCID: PMC4348093.

3. Information Theory and Physiological Complexity: I have worked on a number of physiological problems where we employed and advanced novel methodologies for assessing causal physiological mechanisms and their deterioration with the onset of disease. In a recent paper we developed a technique for studying nonlinear directional relationship among physiological variables based on the concept of entropy transfer. More recently, I developed a point-process Granger causality model of various factors (including sleep structure) leading to secretion of the Luteinizing hormone (an irregularly spaced point process event) involved in reproduciton. This work was done in collaboration with the Masachussetts General Hospital, Reproductive Endocrine Unit.

a. Lee J, Nemati S, Silva I, Edwards BA, Butler JP, Malhotra A. Transfer entropy estimation and directional coupling change detection in biomedical time series. Biomed Eng Online. 2012 Apr 13;11:19. PubMed PMID: 22500692; PubMed Central PMCID: PMC3403001. b. Nemati S, Edwards BA, Lee J, Pittman-Polletta B, Butler JP, Malhotra A. Respiration and heart rate complexity: effects of age and gender assessed by band-limited transfer entropy. Respir Physiol Neurobiol. 2013 Oct 1;189(1):27-33. PubMed PMID: 23811194; PubMed Central PMCID: PMC3821922. c. Shaw ND, Butler JP, Nemati S, Kangarloo T, Ghassemi M, Malhotra A, Hall JE. Accumulated deep sleep is a powerful predictor of LH pulse onset in pubertal children. J Clin Endocrinol Metab. 2015 Mar;100(3):1062-70. PubMed PMID: 25490277; PubMed Central PMCID: PMC4333042.

4. Computational Neuroscience: From 2005-2007, as a member of the Symbiotic Computing Laboratory at the University of Oklahoma and in collaboration with the University of Chicago, I developed a neural decoder (a mathematical model that maps neural activities into hand kinematics) for neural prosthetics applications which was successfully tested in a clinical setting (see Fagg et al, J Neurosci, 2007). Every year hundreds of thousands of Americans suffer from debilitating effects of spinal cord injuries, neuromuscular and movement disorders. The goal of this research was to leverage new advances in machine learning and stochastic modeling to design reliable, high- performance, and computationally efficient adaptive machine learning algorithms for controlling neuromotor prosthetic system.

a. Fagg AH, Hatsopoulos NG, de Lafuente V, Moxon KA, Nemati S, Rebesco JM, Romo R, Solla SA, Reimer J, Tkach D, Pohlmeyer EA, Miller LE. Biomimetic brain machine interfaces for the control of movement. J Neurosci. 2007 Oct 31;27(44):11842-6. PubMed PMID: 17978021; PubMed Central PMCID: PMC2586067.

Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/1-ikxkn1vmb5T/bibliography/45579201/public/ D. Additional Information: Research Support and/or Scholastic Performance Ongoing Research Support K01 ES025445-01A1 Nemati, Shamim (PI) 09/30/15-07/31/20 Deep Learning and Streaming Analytics for Prediction of Adverse Events in the ICU Role: PI

1822378, National Science Foundation Clifford (PI) 04/15/18-02/29/20 Leveraging Heterogeneous Data Across International Borders in a Privacy Preserving Manner for Clinical Deep Learning This project aims to develop a set of distributed deep learning and cloud computation techniques for cross-institution and cross-border machine learning on health and medical data without the need for protected health information to leave the generating institution. It will provide a set of open-source meta algorithms for transfer learning (across domains and tasks) implemented on the cloud in containers (dockers) that can be downloaded for local use or transferred across the different cloud vendors. Role: CPI

Completed Research Support T32 HL007901-13 Czeisler, Charles A (PI) 08/01/98-06/30/13 Training in Sleep, Circadian and Respiratory Neurobiology Role: TA

T32 HL007901-15 Czeisler, Charles A (PI) 08/01/98-06/30/13 Training in Sleep, Circadian and Respiratory Neurobiology Role: TA

T32 HL007901-14 Czeisler, Charles A (PI) 08/01/98-06/30/13 Training in Sleep, Circadian and Respiratory Neurobiology Role: TA

220020352, James S. McDonnell Foundation Shamim Nemati (PI) 01/01/13-12/31/14 Complex Physiological Systems and Big Data: Identifying and Exploiting Switching Dynamics in Multivariate Time Series The goal of this study was to develop a new class of machine learning techniques for analysis of multivariate dynamical patterns in cohort time-series. I made fundamental theoretical contributions to the field of time-series analysis, by combining concepts from the theory of dynamical systems (a subfield of Control Theory) and deep learning (a subfield of Machine Learning). Role: PI

T32HL07901, Ruth L. Kirschstein NRSA Charles A. Czeisler (PI) 06/01/09-12/01/12 Model-based Characterization of Ventilatory Stability Using Spontaneous Breathing The goal of my research under this training grant was to develop computational methods of assessing ventilatory control system instability based on relatively short recordings (10-20min) of spontaneous breathing time series data. I developed a closed-loop identification technique (based on the measurements of the respiratory flow, end-tidal PCO2 and PO2), for assessment of ventilatory control system loop-gain. This work resulted in multiple publications (~10), including a Journal of Applied Physiology paper with an accompanying editorial. Role: TA OMB No. 0925-0001 and 0925-0002 (Rev. 10/15 Approved Through 10/31/2018) BIOGRAPHICAL SKETCH NAME: Lucila Ohno-Machado eRA COMMONS USER NAME: lohnomac POSITION TITLE: Professor of Medicine and Chair, UCSD Health Department of Biomedical Informatics Health Science Research Specialist, San Diego VA EDUCATION/TRAINING Completion INSTITUTION AND LOCATION DEGREE FIELD OF STUDY Date University of Sao Paulo MD 12/1987 Medicine Hospital das Clinicas, University of Sao Paulo Residency 12/1989 Medical Informatics Escola de Administracao de Sao Paulo, FGV MBA 06/1991 Healthcare Administr. Stanford University PhD 03/1996 Medical Inform. Sc. & Computer Sc. (minor) A. Personal Statement I am trained in biomedical informatics. I have experience as former director of the Informatics Core of the Clinical and Translational Science Award (CTSA) at UCSD and as current chair of the UCSD Health Department of Biomedical Informatics (DBMI), a service, research, and teaching unit. I have 20 years of experience in serving as principal investigator/director for federal research grants and service contracts. My research has been focused on privacy-protecting data sharing and construction and evaluation of data mining and decision support tools for biomedical research and clinical care. My interests include also electronic tiered informed consent for data and biospecimen use for research. I have experience in organizing large multidisciplinary teams, consensus building and directing different consortia: (1) the patient-centered SCAlable National Network for Effectiveness Research (pSCANNER) project, a clinical data research network funded by PCORI (Patient Centered Outcomes Research Institute) that queries electronic health records (EHRs) of over 30 million unique patients located in all US states and territories; (2) UC-Research exchange, a University of California-wide initiative to integrate data warehouses from their five medical centers that I co-founded in 2010; (3) the Data Discovery Index Consortium for the BD2K initiative bioCADDIE; (4) an NIH-funded National Center for Biomedical Computing (NCBC) on integrating Data for anonymization, Analysis, and SHaring (iDASH), for which we developed a private HIPAA-FISMA cloud to allow researchers to perform analytics on personal health identified data and funded pilot projects involving data sharing for minority populations; (5) I am principal investigator of the California Precision Medicine Consortium for the All of Us Research Program, involving seven institutions in the task of enrolling and retaining 15k participants per year. I direct the biomedical informatics training program at UCSD and have previously directed the Harvard-MIT-Tufts program in Boston. I have mentored several trainees on K awards or with other funding sources, who became faculty at prestigious institutions (e.g., Harvard, Vanderbilt, UCLA, Seoul University). 1. Kuo TT, Kim HE, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc. 2017 Nov 1;24(6):1211-1220. PMID:29016974 2. Ohno-Machado L, Sansone S, Alter G, Fore I, Grethe J, Xu H, Gonzalez-Beltran A, Rocca-Serra P, Soysal E, Bell E, Gururaj A, Zong N, Kim HK. Finding useful data across multiple biomedical data repositories using DataMed. Nat Genet. 2017 May 26;49(6):816-819. PMID:28546571 3. Kim H, Bell A, Kim J, Sitapati A, Ramsdell J, Farcas C, Friedman D, Feupe SF, Ohno-Machado L. iCONCUR: informed CONsent for Clinical data Use for Research. J Am Med Inform Assoc. 2017, 24(2):382-9. PMID: 27589942 4. Meeker D, Jiang X, Matheny ME, Farcas C, D’Arcy M, Pearlman L, Nookala L, Day ME, Kim KK, Kim H, Boxwala A, El-Kareh R, Kuo GM, Resnic FS, Kesselman C, Ohno-Machado L. A System to Build Distributed Multivariate Models and Manage Disparate Data Sharing Policies: Implementation in the Scalable National Network for Effectiveness Research. J Am Med Inform Assoc 2015, 22(6):1187-95. PMID: 26142423 B. Positions and Honors Positions and Employment 1991-1996 Fellow, Medical Informatics, Department of Medicine, Stanford University School of Medicine 1996-1998 Instructor in Radiology, Harvard Medical School 1996-2009 Affiliated Faculty, Health Sciences and Technology Division, Harvard-MIT 1998-2001 Assistant Professor of Radiology, Harvard Medical School, Brigham and Women’s Hospital 1999- Director, Biomedical Research Informatics for Global Health Training Program (formerly ITMI) 2001-2009 Associate Professor of Radiology, Harvard Medical School, Brigham and Women’s Hospital 2007-2009 Director, Decision Systems Group, Brigham and Women’s Hospital 2007-2009 Director, Boston Biomedical Informatics Research Training Program (Harvard-MIT, BU, Tufts) 2009- Professor of Medicine and Chief, Division of Biomedical Informatics, UCSD 2011- Associate Dean for Informatics and Technology, School of Medicine, UCSD 2012- Director, San Diego Biomedical Education and Research Training Program, UCSD 2013-2015 Research Health Science Specialist, VA San Diego Healthcare System 2015- Chair, UCSD Health Department of Biomedical Informatics, UCSD Other Experience and Professional Memberships 1999-2003 Biomedical Library & Informatics Review (NIH Study Section), National Library of Medicine 2000-2003 Reviewer for the Norges Forskningsrad (Norwegian Research Council) 2001-2012 Member, NIH Special emphasis panels for the NCRR, NHLBI, NLM, NIAID 2001-2011 Member of the editorial boards of Journal of Biomedical Informatics, Genomics and Informatics 2005-2010 Member of the editorial board, Journal of the American Medical Informatics Association 2005-2010 Member of the editorial board, Cancer Informatics 2007-2010 Associate Editor, Journal of the American Medical Informatics Association 2008 Member of the advisory board: Stanford Univ/Univ Western Cape Bioinformatics Program 2008 Reviewer, Welcome Trust Science Program 2008 Vice-Chair, Scientific Program Committee, Am Med Informatics Association Annual Symposium 2009 Reviewer, NASA/NSBRI Crew Health and Performance Research Program 2009 Chair, Scientific Program Committee, Am Med Informatics Association Annual Symposium 2009 Co-Chair, Clinical Data Access Taskforce, UCSD Medical Center 2010 Associate Editor: Journal of Biomedical Informatics 2011-2018 Editor-in-Chief, Journal of the American Medical Informatics Association 2011,2016 Chair, UC Research Exchange Steering Committee, University of California (rotates yearly) 2012 Member, Data and Informatics Working Group for the Advisory Committee to the NIH Director 2012 Panelist, Office of Science Technology and Policy of the president “Big Data” announcement 2012 Chair, 2nd IEEE Health Informatics, Imaging, and Systems Biology Conference 2011- Co-organizer, Privacy Technology Workshops, iDASH National Ctr for Biomedical Computing 2012 Member of the Planning Committee, Digital Data Utility Priorities for Continuous Learning and Improvement in Health, Institute of Medicine of the National Academy of Sciences 2012 Reviewer for the Flanders Foundation (Belgium) and for the Finnish Research Academy 2012-2016 Council member for the National Human Genome Research Institute (NHGRI), NIH 2013 Co-Chair, Workshop on Interactive Systems in Healthcare (WISH), ACM 2014- Member, Steering Committee, Patient-Centered Outcomes Research Network (PCORnet) 2015 Reviewer for the Veteran’s Administration grant panel on Health Services Research 2016-2018 Advisor for the Training Program, NHGRI 2016-2018 Advisory Board, University of California Santa Cruz Center for Translational Genomics 2016 Steering Committee, NIH All of Us Research Program (Precision Medicine Initiative) 2017 Advisor, eMERGE (Electronic Medical Records and Genomics Program) 2017 Academic Consultation Panel for the Faculty of Science, Hong Kong Baptist University 2017- Member, Steering Committee and of the Breach Notifications Board, AllofUs Research Program 2018- Member, Science Committee, All of Us Research Program Awards and Honors 1994 Doctoral Dissertation Award, Agency for Health Care and Policy Research, DHHS 1994 Best Theoretical Paper, Student Paper Competition, American Medical Informatics Association 1994 Martin Epstein Award, American Medical Informatics Association 1995 Dean’s fellowship award, Stanford University School of Medicine 1997 James A. Shannon Director’s Award, Office of the Director, NIH 1999 Taplin Award, Division of Health Sciences and Technology, Harvard/MIT 2000 Award for Outstanding Contributions to Research, Dept. Radiology, Brigham and Women’s Hospital 2002 Elected fellow, American College of Medical Informatics 2004 Clifford A. Barger mentoring award, Harvard Medical School 2007 Elected fellow, American Institute for Medical and Biological Engineering 2007 Distinguished Chair in Biomedical Informatics, Brigham and Women’s Hospital 2010 Elected member, American Society for Clinical Investigation 2011 University-wide Equal Opportunity and Diversity Award, Community Champion, UCSD 2012 Women Who Mean Business Award, San Diego Business Journal 2013 Distinguished Paper, American Medical Informatics Association Summits on Translational Science 2015 Chancellor’s Award for Excellence in Postdoctoral Mentoring, UCSD 2015 Larry L. Sautter Golden Award. University of California Information Technology Leadership Council 2016 Office of the National Coordinator for Healthcare IT/NIST Blockchain Challenge Winner 2018 Leadership Award, American Medical Informatics Association 2018 Elected Member, National Academy of Medicine C. Contributions to Science 1. Predictive Models. My early work focused on novel models for machine learning based on neural networks for decomposable problems of a hierarchical nature. I have subsequently focused on the problem of calibrating individual estimates of predictive models for binary outcomes, particularly those that generate a probability for an event. Some models may have high discrimination but low calibration, and thus be inappropriate for making individualized predictions. Our team has shown that calibrated predictions can help detect suspicious accesses to electronic health records, and that new algorithms for machine learning take into account calibration in their loss functions (1a). This work is continuing with the development of additional algorithms that take into account the error in individualized predictions to build better calibrated predictive models for a variety of applications (1b,1c, 1d, see also PubMed bibliography link for specific models using molecular and/or clinical data), and it is a critical component in the implementation of precision medicine. a. Menon AK, Jiang X, Kim J, Vaidya J, Ohno-Machado L. Detecting Inappropriate Access to Electronic Health Records Using Collaborative Filtering. Mach Learn. 2014;95(1):87-101. PMID: 24683293 b. Amarasingham R, Audet AM, Bates DW, Glenn Cohen I, Entwistle M, Escobar GJ, Liu V, Etheredge L, Lo B, Ohno-Machado L, Ram S, Saria S, Schilling LM, Shahi A, Stewart WF, Steyerberg EW, Xie B. Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges. EGEMS (Wash DC). 2016;4(1):1163. eCollection 2016. PMID:27141516 c. Gabriel RA, Waterman RS, Kim J, Ohno-Machado L. A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries. Anesth Analg. 2017;124(5):1529-1536. PMID:28079580 d. Malhotra R, Kashani KB, Macedo E, Kim J, Bouchard J, Wynn S, Li G, Ohno-Machado L, Mehta R. A risk prediction score for acute kidney injury in the intensive care unit. Nephrol Dial Transplant. 2017;32(5):814- 822. PMID:28402551 2. Privacy Technology Algorithms. Machine learning models require large amounts of training and test data for good performance. Disclosure of clinical data can violate individual privacy, even when data are de-identified according to the Health Insurance Portability and Accountability Act (HIPAA). To disclose data with a known risk of re-identification, it is necessary to introduce a controlled amount of noise. Building on the foundations of differential privacy, our team has developed algorithms to disclose data with a specified privacy guarantee (i.e., quantified risk of re-identification), including the use of public data to decrease the amount of noise that is necessary, construction of GWAS data sets that are differentially private, encryption-based approaches, and protection of SNV queries (2a,2b,2c,2d). This work is continuing with the development of differentially private disclosure models and tools that incorporate publicly accessible data without access controls. a. Wang S, Jiang X, Tang H, Wang X, Bu D, Carey K, Dyke SO, Fox D, Jiang C, Lauter K, Malin B, Sofia H, Telenti A, Wang L, Wang W, Ohno-Machado L. A community effort to protect genomic data sharing, collaboration and outsourcing. NPJ Genom Med 2017;2:33. PMID:29263842 b. Raisaro JL, Tramer F., Zhanglong J, Bu D, Zhao Y, Carey K, Lloyd D, Sofia H, Baker D, Flicek P, Shringarpure S, Bustamante C, Wang S, Jiang X, Ohno-Machado L, Tang H, Wang X, Hubaux JP. Addressing Beacon Re-identification Attacks: Quantification and Mitigation of Privacy Risks. J Am Med Inform Assoc. 2017;24(4):799-805. PMID:28339683 c. Chen F, Wang S, Jiang X, Ding S, Lu Y, Kim J, Sahinalp SC, Shimizu C, Burns JC, Wright VJ, Png E, Hibberd ML, Lloyd DD, Yang H, Telenti A, Bloss CS, Fox D, Lauter K, Ohno-Machado L. PRINCESS: Privacy-protecting Rare disease International Network Collaboration via Encryption through Software guard extensionS. Bioinformatics. 2017;33(6):871-878. PMID:28065902 d. Wang M, Ji Z, Wang S, Kim J, Yang H, Jiang X, Ohno-Machado L. Mechanisms to protect the privacy of families when using the transmission disequilibrium test in genome-wide association studies. Bioinformatics. 2017;33(23):3716-3725. PMID:29036461 3. Distributed Analytics Algorithms. Due to institutional policies or international regulations, it is not always possible to physically share patient data for analyses. For example, the Veteran’s Administration (VA) and the UK data protection act would make it difficult to use clinical data from the VA or the UK for research. However, it is possible to submit computation requests to the data host and combine their results with those of multiple others in order to build accurate predictive models in a distributed manner. Our team has decomposed multivariate regression algorithms and developed corresponding tools showing that the resulting models built from these “horizontally” partitioned data (i.e., data sets in which different patients are located at each site) are essentially identical to those that would be have obtained if all data were centralized. Our seminal paper decomposing the calculation of the binary response logistic regression model and of the area under the ROC curve was published in 2012. It was subsequently extended it to be done in an online (3a) in addition to the batch approach previously used. A corresponding web service was developed (3b), and recently ore recently models for distributed computing in vertically partitioned data (i.e., data sets in which different variables from the same patient are distributed across sites) were also published (3c). Distributed analytics is important to allow a larger number of institutions participate in the development of multivariate models. This work is continuing with upcoming publications in distributed Cox Proportional Hazards models, as well as with optimization of distributed analytics over vertically-partitioned data and record linkage (3d). a. Wang S, Jiang X, Wu Y, Cui L, Cheng S, Ohno-Machado L. EXpectation Propagation LOgistic REgRession(EXPLORER): Distributed Privacy-Preserving Online Model Learning. J Biomed Inf 2013, 46(3):480-96. PMID: 23562651 b. Jiang W, Li P, Wang S, Wu Y, Xue M, Ohno-Machado L, Jiang X. WebGLORE: A Webservice for Grid LOgistic REgression. Bioinformatics. 2013;29(24):3238-40. PMID: 24072732 c. Li Y, Jiang X, Wang S, Xiong H, Ohno-Machado L. Vertical Grid Logistic Regression (VERTIGO). J Am Med Inform Assoc. 2016,23(3):570-9. PMID: 26554428 d. Chen F, Jiang X, Wang S, Schilling LM, Meeker D, Ong T, Matheny ME, Doctor JN, Ohno-Machado L, Vaidya J. Perfectly Secure and Efficient Two-Party Electronic-Health-Record Linkage. IEEE Internet Comput. 2018;22(2):32-41. PMID:29867290 4. Clinical Data Research Networks. Organizing large clinical data research networks (CDRN) involving diverse partners is challenging because of data governance on diverse state regulations, institutional policies, and health system interests. We developed and implemented a privacy and security policy framework (4a) and data governance requirements (4b) that served as the basis for a large CDRN covering all five University of California medical centers, the national VA enterprise data warehouse, and some safety net clinics in the Los Angeles area: patient-centered Scalable National Network for Effectiveness Research (pSCANNER) (4c). This network was built from a precursor network in which we built software for distributed analytics, such as the one described in (3a), using data harmonized into a common data model (4d). This work is continuing in phase II of PCORnet, the national clinical data research network funded by PCORI. a. Kim K, McGraw D, Mamo L, Ohno-Machado L. Development of a Privacy and Security Policy Framework for a Multi-State Comparative Effectiveness Research Network. Medical Care 2013;51(8 Suppl 3): S66-72. PMID: 23774516 b. Kim KK, Browe DK, Logan HC, Holm R, Hack L, Ohno-Machado L. Data Governance Requirements for Distributed Clinical Research Networks: Triangulating Perspectives of Diverse Stakeholders. J Am Med Inform Assoc 2014, 21(4):714-9. PMID: 24302285 c. Ohno-Machado L, Agha Z, Bell DS, Dahm L, Day ME, Doctor JN, Gabriel D, Kahlon MK, Kim KK, Hogarth M, Matheny ME, Meeker D, Nebeker JR, pSCANNER team. pSCANNER: Patient-Centered SCAlable National Network for Effectiveness Research. J Am Med Inform Assoc 2014;21(4):621-6. PMID: 24780722 d. Fitzhenry F. Resnic F, Robbins SL, Denton J, Nookala L, Meeker D, Ohnno-Machado L. Matheny M. A Creating a Common Data Model for Post Marketing Surveillance with the Observational Medical Outcomes Partnership. Appl Clin Inform. 2015;6(3):536-47. PMID: 26448797 5. Data Integration and Sharing. In both centralized and distributed models, it is critically important that data be harmonized (“standardized”) so that they are comparable across sites. Our NIH-funded National Center for Biomedical Computing focused on data integration, “anonymization” (privacy technology), and sharing (5a). A conceptual model identified three key data sharing models (5b), for which new technologies such as those discussed in items 2 (Privacy Technology) and 3 (Distributed Analytics) were developed. On the integration aspect, our team standardized over 180,000 phenotype variables in dbGaP using a combination of natural language processing and human curation (5c). With respect to sharing, we were the first to study patient attitudes towards sharing clinical data for research and for healthcare in the same population. That is, the same patient offered responses to questions related to sharing for clinical care and sharing for research (5d). This work is continuing with a clinical trial on implementation of patient preferences in research data delivery services. a. Ohno-Machado L, Bafna C, Boxwala A, Chapman BE, Chapman WW, Chaudhuri K, Day M, Farcas C, Heintzman N, Jiang X, Kim H, Kim J, Matheny M, Resnic F, Vinterbo S, iDASH. Integrating data for analysis, anonymization, and sharing. J Am Med Inf Assoc 2012;19(2):196-201. PMID: 22081224 b. Ohno-Machado L. To Share or Not to Share: That is Not the Question. Sci Transl Med. 2012;4(165):165cm15. PMID: 23253606 c. Doan S, Lin K, Conway M, Ohno-Machado L, Hsieh A, Feudjio-Feupe S, Garland A, Ross MK, Jiang X, Farzaneh S, Walker R, Alipanah N, Zhang J, Xu H, Kim H. PhenDisco: Phenotype Discovery System for the Database of Genotypes and Phenotypes. J Am Med Inform Assoc 2013; 21(1):31-6. PMID: 23989082 d. Kim, KK, Joseph JG, Ohno-Machado L. Comparison of Consumers’ Views on Electronic Data Sharing for Healthcare and Research. J Am Med Inform Assoc. 2015;22(4):821-30. PMID: 25829461 Complete List of PubMed Indexed Articles: http://www.ncbi.nlm.nih.gov/pubmed?term=ohno-machado D. Research Support Ongoing Research Support Protecting Privacy and Facilitating Shared Access of Clinical and Genetic Data of Special Populations R01HL136835 Role: PI 09/01/17 – 08/31/21 PI: Ohno-Machado We will develop decentralized secure privacy-protecting computation for studies on American Indian cohorts. CALIFORNIA: Cloud-agnostic Architecture to Locate Indexed FAIR Objects and safely Reuse then in New Integrated Analyses. OT3OD025462 Role: MPI 09/30/2017 – 11/30/18 MPI: Ohno-Machado We will explore indexing and blockchain technology for the NIH Data Commons. Sansone, Xu California Precision Medicine Consortium MPI: Ohno-Machado, Anton-Culver OT2OD026552 Role: MPI 04/01/18 – 03/31/23 Regional medical center for All of Us (Precision Medicine Initiative) involving six institutions in California. Decentralized differentially-private methods for dynamic data research and analysis NIH R01GM118609 Role: MPI 12/01/16 – 11/31/20 MPI: Ohno-Machado, Jiang Develop a privacy-preserving decentralized framework for cross-institutional data dissemination and analysis. patient-Centered SCAlable National Network for Effectiveness Research MPI: Ohno-Machado, CDRN-1306-04819 Phase 2 Role: MPI 10/01/15 – 03/30/19 Matheny, Meeker, Schilling PCORnet clinical data research network based on the implementation of distributed analytics. iCONCUR: informed CONsent for Clinical data and biosample Use for Research PI: Ohno-Machado This project extends our pilot on e-Tiered Consent for healthcare provider organizations in a multi-center trial. CYCORE2: Cyberinfrastructure for Cancer Comparative Effectiveness Research PI: Patrick NIH R01 CA177996 Role: Co-Investigator 05/01/14 – 03/31/19 This project uses the iDASH infrastructure for comparative effectiveness research in cancer studies. Encryption methods and software for privacy-preserving analysis of biomedical data PI: Tang (IU) U01EB023685 Role: Site PI 09/30/16 – 06/30/19 Open-source plug-and-play software for the statistical analysis of encrypted biomedical data.

Past Research Support bioCADDIE: Biomedical and healthCAre Data Discovery and Indexing Ecosystem PI: Ohno-Machado NIH U24AI117966 Role: PI 09/01/14 – 08/31/18 Coordinating consortium engaging community for metadata specifications, data discovery index development. Design and Evaluation of User Centered Electronic Health Records PI: Ohno-Machado VA IIR 12-068 Role: PI 10/01/15 – 09/30/18 This project aims at developing better user interfaces for VA’s electronic health records. Impact of Privacy Environments for Personal Health Data on Patients PI: Bloss R01 HG008753 Role: Co-Investigator 09/01/15 – 08/31/18 Qualitative research about patient perceptions of privacy in various environments. iDASH: Integrating Data for Analysis, ‘anonymization’ and SHaring PI: Ohno-Machado NIH U54HL108460 Role: PI 09/20/10 – 09/30/17 National Center for Biomedical Computing for HIPAA-FISMA computing, privacy-protecting data sharing. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Sitapati, Amy M. M.D. POSITION TITLE: Clinical Professor of Medicine with appointments in Division of Internal Medicine and Biomedical Informatics Chief Medical Information Officer of Population Health, UC San Diego Health Internist, La Jolla Internal Medicine, UCSDH EDUCATION/TRAINING DEGREE Completion (if Date FIELD OF STUDY INSTITUTION AND LOCATION applicable) MM/YYYY

Case Western University, Cleveland, OH B.S. 5/94 Biomedical Engineering Case Western University, Cleveland, OH M.D. 5/98 Medicine University of California, San Diego, Health Systems, Residency 6/01 Internal Medicine Dept. of Internal Medicine

Anderson School of Business, The University of Mini-MBA 7/08 Business Administration California, Los Angeles

Partial Clinical Research The University of California, San Diego, CA 1/09 Completion Enhancement Supplemental Training

(CREST)

Health Sciences The University of California, San Diego, CA Completed 5/13 Leadership Academy (HSLA)

A. Personal Statement

As Chief Medical Information Officer of the Population Health for UC San Diego Health, I provide strategic vision and oversight related to value based care delivery. Our vision is to deliver outstanding analytics and population health through innovative use of the electronic health record. In this role, I am also responsible for defining short and long term planning, obtaining project funding, providing supervision, defining a project’s organizational value, including key stakeholders, determining project requirements, meeting a project timeline, defining and coordinating implementation plans, creating a training plan, defining cost, and evaluating expected return on investment. I design enterprise solutions that improve quality, safety, and outcomes through systems that support workflows for organizational goals. As the executive lead at UCSDH for an estimated $25m annually in the PRIME and QIP programs, I am responsible for leading more than 16 active projects with more than 150 active team members. Additionally, I am responsible for visioning the IS quality infrastructure related to P4P, PQRS, MU, CDC, MACRA, and our ACO. I work to align health system resources with the Chief Medical Officer, Chief Information Officer, Departmental Chairs, Division Chiefs, Dean of Clinical Affairs, Risk Management, Compliance, and Chief Strategy Officer.

As a physician leader, my expertise including Board Certification in Clinical Informatics and Internal Medicine as well as technical knowledge as an engineer and lean enable me to create solutions that improve population health. I have experience in working with analysts across a variety of EMR Epic applications and am certified as an Epic Physician Builder. With more than a decade of experience in quality improvement, I bring substantial experience in using data to drive improved clinical workflows that ultimately provide healthier patient populations. Through this experience, I have developed expertise in patient centered care delivery, research on populations with health disparities, development of a chronic disease registry, implementation of risk acuity scoring, dynamic decision support, quality improvement including PDSA and Lean, qualitative research, and oversight of a patient advisory board. I have worked to integrate research, continuous quality improvement, and healthcare delivery in medical practice.

My prior research has included population management, registry, decision support, disease management, meaningful use, provider efficiency, patient safety, reporting analytics, and quality improvement. I have become a nationally recognized leader pioneering the delivery of HIV primary care in a Patient Centered Medical Home (PCMH) at UC San Diego Health System (UCSDHS), one of five public institutions selected in California. In addition to a $1.2 million grant from the HIV/AIDS Research Program (CHRP), I also served as the health system lead for the Delivery System Reform Incentive Payments (DSRIP) for Category 5 HIV transitions project that generated an estimated $20 million to the UCSDHS, nationally recognized by CMS as best in class. As part of the California HIV/AIDS Research Program (CHRP) through the local California Clinical Trials Group (CCTG), I have experience working in a multi-site collaborative to improve patient engagement in care. As former Principal Investigator for the San Diego Regional Pacific AIDS Education and Training Centers Program, I have ample experience providing physician and staff level training including capacity development to community providers.

B. Positions and Honors 2001 – Present Board Certified in Internal Medicine 2005 – 2012 HIV Specialist 2005 – 2007 Assistant Professor, Howard University School of Medicine, Washington DC 2007 – 2008 Associate Physician, University of California San Diego, Owen Clinic, San Diego, CA 2008 – 2012 Associate Director, Owen Clinic 2008 – Present Quality Improvement Representative, Department of Medicine 2008 – 2014 Associate Clinical Professor of Medicine, University of California San Diego, Owen Clinic 2011 - 2014 AMC: AIDS Malignancy Consortium 2012 – 2014 Interim Director, Owen Clinic 2013 – Present Board Certified in Preventive Medicine in Clinical Informatics 2014 - Present Clinical Professor of Medicine, University of California San Diego, Internal Medicine 2014 Epic Physician Builder 2014 Completion of Lean Expert training through Pyzdek 2014 Nominated candidate for Truax Award 2014 Completed Epic Healthy Planet training (pending project/exam) 2015 VITAL 2015 recipient of the "remarkable project" Gage Award 2015 - 2016 Medical Director, La Jolla Internal Medicine UCSDH 2015 – 2016 Director Population Health, Clinical Systems UCSDH 2015 – 2017 AHRQ HIT Study Section 2016 – Present AMDIS member 2016 - Present CHIME member and faculty 2016 – Present National Comprehensive Cancer Network, Breast Committee Member 2016 – Present Chief Medical Information Officer of Population Health for UC San Diego Health

C. Contribution to Science: Development of Value based Analytics Population Health Program. Our development of a robust population health infrastructure includes more than 70 registries, real-time ad hoc reporting via SlicerDicer, and integrated data that supports quality reporting.

1. Sitapati A, Kim H, Berkovich B, Marmor R, Singh S, El-Kareh R, Clay B, Ohno-Machado L. Integrated precision medicine:the role of electronic health records in delivering personalized treatment. Wiley Interdiscip Rev Syst Biol Med. 2017 Feb 16. PMID: 28207198 2. Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, Elias AD, Farrar WB, Forero A, Giordano SH, Goetz MP, Goldstein LJ, Isakoff SJ, Lyons J, Marcom PK, Mayer IA, McCormick B, Moran MS, O'Regan RM, Patel SA, Pierce LJ, Reed EC, Salerno KE, Schwartzberg LS, Sitapati A, Smith KL, Smith ML, Soliman H, Somlo G, Telli M, Ward JH, Shead DA, Kumar R. (1. 2017) NCCN Guidelines Insights: Breast Cancer, J Natl Compr Canc Netw. 2017 Apr;15(4):433-451. 3. Chair: Sitapati A, UCSD Population Health and Value Based Analytics, August 2017 (120 attendees) Sitapati A, UCSD Population Health BootCamp, August 2016 (80 attendees local and national) 4. Medical School course: UCSD MED269 Co-Chair Sitapati A and Killeen J (2016 – 2017).

Successful pivot of a Patient Centered Model of HIV care delivery at an academic medical center. Our work resulted in a VITAL 2015 remarkable project Gage Award. Through implementation of patient centered model of care delivery, we were able to meet the DSRIP targets of 9/10 measures and improve patient performance. Our success was rooted in a robust understanding of quality improvement, data driven workflows, and patient engagement.

1. Corado K, Jain S, Morris S, Dube MP, Daar ES, He F, Aldous JL, Sitapati A, Haubrich R, Milam J, Young Karris M (2018) Randomized Trial of Health Coaching Intervention to Enhance Retention in Care: California Collaborative Treatment Group 594 AIDS and Behavior pp 1-13: 2018 May 03. 2. Sitapati, A. (2012). Implementing QI in HIV Clinics to Improve Retention in Care. Medscape HIV/AIDS. http://www.medscape.com/viewarticle/775137 3. Sitapati, A. M., Limneos, J., Bonet-Vazquez, M., Mar-Tang, M., Qin, H., & Mathews, W. C. (2012). Retention: building a patient-centered medical home in HIV primary care through PUFF (Patients Unable to Follow-up Found). J Health Care Poor Underserved, 23(3 Suppl), 81-95. doi: 10.1353/hpu.2012.0139

Video Link to PCMH work include: YouTube: Patient Centered Medical Home Project – Voices from the Field http://www.youtube.com/watch?v=yrXh9UO4Q0E Created Patient Centered Owen Clinic website: http://owenclinic.ucsd.edu/Pages/default.aspx

Enhanced understanding of HIV testing and HIV related opportunistic infections. Earlier work in HIV Primary Care delivery included the first hospital to implement routinized HIV screening in the nation. This program was visited by the First Lady Laura Bush. Two articles were also published about cryptococcal meningitis. 1. Cachay, E. R., Caperna, J., Sitapati, A. M., Jafari, H., Kandel, S., & Mathews, W. C. (2010). Utility of clinical assessment, imaging, and cryptococcal antigen titer to predict AIDS-related complicated forms of cryptococcal meningitis. AIDS Res Ther, 7, 29. doi: 10.1186/1742-6405-7-29 2. Maxwell, C. J., Sitapati, A. M., Abdus-Salaam, S. S., Scott, V., Martin, M., Holt-Brockenbrough, M. E., & Retland, N. L. (2010). A model for routine hospital-wide HIV screening: lessons learned and public health implications. J Natl Med Assoc, 102(12), 1165-1172. 3. Scott, V. F., Sitapati, A., Martin, S., Summers, P., Washington, M., Daniels, F., . . . Maxwell, C. J. (2009). The Howard University Hospital experience with routineized HIV screening: a progress report. Trans Am Clin Climatol Assoc, 120, 429-434. 4. Sitapati, A. M., Kao, C. L., Cachay, E. R., Masoumi, H., Wallis, R. S., & Mathews, W. C. (2010). Treatment of HIV-related inflammatory cerebral cryptococcoma with adalimumab. Clin Infect Dis, 50(2), e7-10. doi: 10.1086/649553

Improved understanding of anal dysplasia screening. Persons living with HIV have substantially higher risk for HPV associated Anal Dysplasia. UCSDH provides one of the few places in Southern California to receive evaluation and treatment of anal dysplasia. As a co-investigator, we published articles that enhance understanding of the testing and evaluation of patients at risk for anal dysplasia and cancer. 1. Cachay, E. R., Sitapati, A., Caperna, J., Freeborn, K., Lonergan, J. T., Jocson, E., & Mathews, W. C. (2009). Denial of risk behavior does not exclude asymptomatic anorectal sexually transmitted infection in HIV-infected men. PLoS One, 4(12), e8504. doi: 10.1371/journal.pone.0008504 2. Mathews, W. C., Cachay, E. R., Caperna, J., Sitapati, A., Cosman, B., & Abramson, I. (2010). Estimating the accuracy of anal cytology in the presence of an imperfect reference standard. PLoS One, 5(8), e12284. doi: 10.1371/journal.pone.0012284 3. Mathews, W. C., Sitapati, A., Caperna, J. C., Barber, R. E., Tugend, A., & Go, U. (2004). Measurement characteristics of anal cytology, histopathology, and high-resolution anoscopic visual impression in an anal dysplasia screening program. J Acquir Immune Defic Syndr, 37(5), 1610- 1615.

D. Current Research 1. Impact of terminology Mapping on Population health Cohorts (IMPaCt). 2017 – Current Role: Principal Investigator Major Goals: To compare ICD and SNOMED phenotype algorithms 2. All of Us NIH Research Program 2017 - Current Role: Investigator Major Goals: This project aims to recruit nationally nearly 1 million participants for precision medicine 3. California Integrated Vital Records System (CALIVRS) State of CA Vital Records 2017-19 Role: Local Principal Investigator Major Goals: This projects aims to make California Vital Records available for public use.

E. Completed Recent Research 1. Delivery System Reform Incentive Pool (DSRIP) for Category 5 HIV transitions 7/1/2012 – 12/31/2013 Role: Principal Investigator/Physician Lead Major Goals: To improve quality outcomes for patients receiving HIV primary care through a patient centered medical home model of care delivery. 2. California HIV/AIDS Research Program: MH10-UCSD-640 12/01/2010 – 11/30/2014 ANCHOR: A Novel Care Home Optimizing Retention Role: Principal Investigator Major Goals: This project will strive to improve the construction of a model HIV primary care medical home. 3. HRSA/CFDA no: 93.145; Federal Grant No. 6H4AHA00058 07/01/2002-06/30/2014 Regional AIDS Education and Training Centers Program Role: Principal Investigator Major Goals: To provide comprehensive HIV training to healthcare providers regionally 4. CFDA no: 93.145; Federal Grant No. 6 H76 HA00190-12 07/01/1997-04/30/2013 Outpatient Early Intervention Services (EIS/MAI) with Respect to HIV Disease Role: Principal Investigator/Program Director Major goals: Treatment of HIV+ patients who have no insurance coverage beside Ryan White CARE act. 5. HRSA/Capacity Development Award P06HA28065 09/2014-08/2015 Investigator: Amy M. Sitapati, M.D. Major Goals: Improve patient engagement in MyChart and Retention in Care

6. California HIV/AIDS Research Program: CCTG ALERT – Active Linkage, Engagement, and Retention to Reduce HIV Award EI11-SD-005 04/01/2012-03/30/16 ALERT-Active Linkage, Engagement and Retention to Reduce HIV Protocol Investigator: Amy M. Sitapati, M.D. Major Goals: Project to improve HIV retention in care. Jonathan H. Watanabe, PharmD, MS, PhD, BCGP

April 2018

BIOGRAPHICAL INFORMATION

Associate Professor of Clinical Pharmacy Division of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego 9500 Gilman Drive Mail Code 0764 La Jolla, CA 92093-0764 858-829-0122 [email protected]

Born: Omaha, NE Citizenship: US

EDUCATION

BS, Zoology, Minor, History, University of Washington, Seattle, WA PharmD, University of Southern California, Los Angeles, CA MS, Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA PhD, CHOICE Institute, University of Washington, Seattle, WA

POST GRADUATE TRAINING

2007 – 2009 University of Washington and Allergan Fellowship in Global Health Economics and Outcomes Research. University of Washington CHOICE Instiute and Allergan Global Health Outcomes Strategy and Research Department. Seattle, WA. Irvine, CA.

FACULTY POSITIONS

2012 – 2013 Assistant Professor, Department of Pharmacy Practice and Administration, Western University of Health Sciences College of Pharmacy, Pomona, CA. 2013 – 2017 Assistant Professor of Clinical Pharmacy, Division of Clinical Pharmacy, University of California (UC) San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS), La Jolla, CA. 2017 – present Associate Professor of Clinical Pharmacy, Division of Clinical Pharmacy, University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA.

PHARMACIST POSITIONS

2009 Long Term Care Clinical Pharmacist, Rx2 Pharmacy Services, Orange, CA 2009 – 2012 Long-Term Care Clinical Pharmacist, Mercury Pharmacy Services, Mountlake Terrace, WA 2015 – 2017 Clinical Pharmacist, San Diego Program of All-inclusive Care for the Elderly (PACE) Clinic, San Ysidro, CA 2017 – Present Clinical Pharmacist, Villa Pomerado Skilled Nursing Facility, Pomerado Hospital, Palomar Health, Poway, CA

HONORS

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 2

2007 Recipient, Harold Miller Leadership Plaque. University of Southern California (USC) School of Pharmacy. 2010 President’s Research Initiative Award, American Association of Neuromuscular and Electrodiagnostic Medicine Annual Meeting. October 2010. 2010 High-quality peer review recognition. Journal of Managed Care Pharmacy. Editor- in-Chief Fred Curtiss. June 2010. 2014 Selected faculty for National Center for Leadership in Academic Medicine. UC San Diego School of Medicine 2014 Platinum Award for Top Research Abstract. Academy of Managed Care Pharmacy (AMCP) Nexus Conference. Boston, MA. 2014 Bronze Medal Poster Award for research abstract. AMCP Nexus Conference. Boston, MA. 2015 AMCP Pharmacy and Therapeutics Student Competition National Finalist. Faculty Advisor for team reaching the national finals from UCSD SSPPS. AMCP Annual Conference. San Diego, CA. 2016 AMCP Pharmacy and Therapeutics Student Competition National Finals First Place Winner. Faculty Advisor. AMCP Annual Conference. San Francisco, CA. 2016 – present National Academy of Medicine (formerly the Institute of Medicine) Anniversary Fellow in Pharmacy. National Academy of Sciences, Engineering, and Medicine. Washington, DC. 2016 – present National Institutes of Health (NIH) Loan Repayment Program Awardee. 2017 – present Faculty-in-Residence. UC San Diego Cross Cultural Center. 2017 Bronze Medal Poster Award. AMCP Nexus Conference. Grapevine, TX. 2017 Gold Medal Poster Award. AMCP Annual Meeting. Denver, CO. 2017 Nominee for The University of Washington School of Pharmacy’s 2017-2018 Distinguished Alumnus Award for Excellence in Pharmaceutical Sciences and Research. The University of Washington School of Pharmacy and Pharmacy Alumni Association. 2018 Bronze Medal Poster Award. AMCP Annual Meeting. Boston, MA. 2018 AMCP Pharmacy and Therapeutics Student Competition National Finalist. Faculty Advisor for team reaching the national finals from UCSD SSPPS. AMCP Annual Conference. Boston, MA 2018 National Academy of Medicine Emerging Leader in Health and Medicine

BOARD CERTIFICATIONS

2016 – present Board Certification in Geriatrics Pharmacy. Board of Pharmacy Specialties.

OTHER CERTIFICATIONS

2010 University of Washington School of Pharmacy Teaching Certificate. 2011 Biomedical Researcher Human Subjects Training for NIH investigators. 2015 American Pharmacists Association Medication Therapeutic Management Certification

LICENSURES

2007 – present Washington State Pharmacist License 2009 – present California State Pharmacist License 2011 – present Washington State Pharmacist Preceptor License

PROFESSIONAL ORGANIZATIONS

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 3

2007 – present International Society for Pharmacoeconomics and Outcomes Research 2004 – present Academy of Managed Care Pharmacy 2012 – present American Society of Consultant Pharmacists 2004 – present Omicron Delta Kappa National Leadership Society. 2007 – present Phi Lambda Sigma Pharmacy Leadership Society 2003 – present Lambda Kappa Sigma Professional Pharmacy Society 2014 – 2016 American Academy of Neurology 2014 – 2015 American Diabetes Association 2014 – 2015 San Diego Society for Health Systems Pharmacist 2010 – 2015 American Association of Colleges of Pharmacy. 2008 – 2009 Society for Urodynamics and Female Urogynecology 2007 – 2009 American Urological Association 2006 – 2007 American College of Clinical Pharmacy 2003 – 2007 American Pharmacists Association 2003 – 2007 California Pharmacists Association 2003 – 2012 American Society of Health Systems Pharmacists 2003 – 2012 California Society of Health Systems Pharmacists

EDUCATIONAL ACTIVITIES

Courses

2008 Pharmaceutical Policy Course. University of Washington School of Pharmacy. Lecturer. 2009 Pharmacoeconomics Course. University of Southern California School of Pharmacy. Lecturer 2009 Industry Course. University of Southern California School of Pharmacy. Lecturer 2010 Law and Ethics Course. University of Washington School of Pharmacy. Lecturer 2012 Law and Ethics Course. University of Washington School of Pharmacy. Lecturer 2012 Policy and Advocacy Course. Western University of Health Sciences College of Pharmacy. Pharmacy Practice Management Course. Lecturer 2012 Health Outcomes Course. Western University of Health Sciences College of Pharmacy. Health Outcomes Course. Lecturer 2013 Evidence Based Practice. Western University of Health Sciences College of Pharmacy. Lecturer. 2013 Introduction to Pharmacy and Health Systems Course. Western University of Health Sciences College of Pharmacy. Course Coordinator. 2013 Biostatistics and Study Design Course. Western University of Health Sciences College of Pharmacy. Course Coordinator. 2014 Concepts in Pharmacy Practice. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. Lecturer. 2014 – 2016 Biostatistics Course. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. Course Coordinator. 2014 – 2016 Clinical Research Design Methods. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. Lecturer. 2014 – present Pharmacy Administration Elective Course. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, Course Developer and Coordinator 2017 – present Health Policy. UC San Diego SSPPS Core Course. Course Co-Coordinator. 2017 – present.

Continuing Education Presentations

1. Watanabe JH. Improving management of overactive bladder with novel treatment paradigms localized versus systemic therapy. Invited speaker. Case Management Society of America Annual Conference and Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 4

Expo. May 30, 2013. Orlando, FL. 2. Watanabe JH. Refractory idiopathic and neurogenic detrusor overactivity: case studies of localized treatment modalities. American Urological Association Annual Meeting. May 2011. Washington DC. 3. Watanabe JH. “Inability to receive necessary medications and ER visits in seniors”. First Annual UC San Diego Clinical Geriatrics Interprofessional Symposium. UC San Diego Geriatrics Division and Fellowship Program. Pharmacology Panel. October 5, 2014. La Jolla, CA. 4. Ma SW, Watanabe JH. Association between Mental Health Status and Medication Access, ER Visits, and Hospitalizations in a Nationally Representative Survey Database". Academy of Managed Care Pharmacy 2014 Nexus meeting in Boston, MA October 10, 2014, and for publication in the Journal of Managed Care Pharmacy (JMCP). 5. Watanabe JH. “Pharmacist Outcomes: Application of Health Services Research and Pharmacoeconomic Modeling to Demonstrate Value”. San Diego PharmNet. Panel Speaker. November 13, 2014. UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences. La Jolla, CA. 6. Watanabe JH, Yam FK. “Considerations When Reading and Pursuing Pharmacy and Medical Research”. California Pharmacists Association West Coast Exchange. April 11, 2015. Anaheim, CA. 7. Watanabe JH. “Show me the money: Pharmacoeconomics in the Pharmacy Practice Landscape”. UC San Diego SSPPS Preceptors Conference. Invited speaker. June 27, 2015. La Jolla, CA. 8. Preceptors Skills Conference. Panel speaker. August 1, 2015. La Jolla, CA. UCSD SSPPS. 9. Watanabe JH. “Biomedical research review and journal club primer”. San Diego Geriatrics Workforce Enhancement Program Scholars Series. December 15, 2015. San Ysidro, CA. 10. Park PE, Watanabe JH. “Geriatrics Workforce Enhancement Program: serving the elderly and underserved through an interdisciplinary” Innovations in Medical Education Conference February 19, 2016 University of Southern California Los Angeles, CA 11. Watanabe JH, Park PE, Bae S, Chau DL. “Serving the Underserved: Clinical Pharmacy in Low-Income Senior Primary Care Clinics”. California Pharmacists Association West Coast Exchange. April 30, 2016. San Francisco, CA. Continuing Medical Education Talk. 12. Tam S, Watanabe JH. “High Risk Medication Use in Seniors: A Review of the Recent Evidence”. San Diego Geriatrics Workforce Enhancement Program Scholars Series. May 17, 2016. San Ysidro, CA. 13. Watanabe JH, Kejriwal K. “Adverse Drug Events, Beers Criteria for Potentially Inappropriate Medication Use in Older Adults and Polypharmacy Risk”. December 4, 2016. 3rd Annual UC San Diego Geriatrics Interprofessional Symposium. 14. Watanabe JH, Chau DL. “Older Adults, High Risk Meds, and Polypharmacy” August 22, 2017. Scripps Mercy Hospital Grand Rounds. San Diego, CA. 15. Naderi B, Watanabe JH. “Pharmacist role in wound care”. December 2, 2017. 4th Annual UC San Diego Wound Care Workshop. Las Vegas, NV. 16. Naderi B, Watanabe JH. “Cultural Competency and Medication Adherence”. Integrating Geriatric Care into Federally Qualified Health Center and Safety Net Care. GWEP Networking Event with UC Irvine. Anaheim, CA. December 8, 2017. 17. Naderi B, Watanabe JH. “Influenza: Considerations in Homeless Older Adults”. UC San Diego GWEP Scholar Educational Lecture Series. San Diego, CA. February 2018. 18. Watanabe JH. “Not Letting Them Fall: Medication Considerations and Older Adults”. UC San Diego Clinical Interprofessional Geriatrics Fall Symposium. March 17, 2018. 19. Naderi B, Watanabe JH. “Beers Criteria, High Risk Medications, Polypharmacy: Medication Therapy Considerations in Older Adults”. UC San Diego GWEP Scholar Educational Lecture Series. San Diego, CA. March 2018. 20. Watanabe JH. Geriatric Syndromes: Medication-related financial toxicity; Health Economics and Outcomes Research in Historically Challenging Times. San Diego Geriatrics Workforce Enhancement Program Scholars Program. May 9, 2018.

Trainee Supervisory

Masters Students Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 5

1. Mark Bounthavong, PharmD MPH Thesis Committee Member “Multiple imputation with multivariate models: an evaluation of two case studies”. Rollins School of Public Health. Emory University. 2012 - 2013.

Thesis findings published in peer-reviewed journal Pharmacotherapy in 2015

Residents

1. PoYing Fung, PharmD Western University of Health Sciences College of Pharmacy Role: Western States Residency Project Mentor Project Title: “Determining variables that influence time to therapeutic range in anticoagulant users” February 2013 – May 2013.

Post-Doctoral Fellows

1. Paula Park, PharmD, PhD San Diego Geriatrics Workforce Collaborative Interdisciplinary Fellow for San Diego GWEP Project Title: “Educating health professionals for interdisciplinary senior care practice” Role: Fellowship Director October 2015 – September 2017

Project findings selected for presentation as continuing medical education presentation at Innovations in Medical Education Conference. Los Angeles, CA. February 2016. Project findings selected for presentation at continuing medical education session at California Pharmacists Association West Coast Exchange Conference. San Francisco, CA. April 2016. Published in California Pharmacist journal.

2. Bita Naderi, PharmD San Diego Geriatrics Workforce Collaborative Interdisciplinary Fellow Project Title: “Potentially Inappropriate Medications, Polypharmacy, and Medication Management” Role: Fellowship Director November 2017 – present

Project findings selected for presentation at Western Region Chapter, Aging Life Care Association as a session for the Annual Conference. September 21, 2018. San Diego, CA.

3. Aryana Sepassi, PharmD UC San Diego & Millennium Health Post-doctoral Research Fellowship in Health Economics of Personalized Medicine Project Title: “Resource utilization and charges of patients with and without diagnosed venous thromboembolism during primary hospitalization and after elective inpatient surgery: a retrospective study” Role: Fellowship Steering Committee, Research Mentor

Project findings published as research manuscript with Dr. Sepassi as first author in Journal of Medical Economics in September 2017.

4. Jacinda Tran, PharmD UC San Diego & Millennium Health Post-doctoral Research Fellowship in Health Economics of Personalized Medicine Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 6

Project Title: TBD Role: Fellowship Steering Committee, Research Mentor

Student Pharmacists

1. Jeffrey Dai, third year student pharmacist Western University of Health Sciences College of Pharmacy Role: Research project advisor Project Title: “Impact and outcomes of student pharmacist health screenings” September 2012 – August 2013

2. Suluck Chaturabul, third year student pharmacist Western University of Health Sciences College of Pharmacy Role: Research project advisor Project Title: “Impact and outcomes of student pharmacist health screenings” September 2012 – August 2013

3. Danial Husain, second year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Advisor Project Title: “Health Services Utilization of Intravenous Immunoglobulin (IVIG): Predictive Variables for Adverse Events and Non-Adherence in IVIG Patients.” June 2014 – October 2014

Project was awarded Bronze Award for research excellence at Academy of Managed Care Pharmacy (AMCP) Nexus Conference October 2014 in Boston, MA.

4. Samantha Ma, second year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Advisor (T32 award funded) Project Title: “Association between Mental Health Status and Medication Access, ER Visits, and Hospitalizations in a Large, Nationally Representative Survey Database.” June 2014 – October 2014

Project was awarded Platinum Award for top research abstract and selected for oral podium session at AMCP Nexus Conference October 2014 in Boston, MA. Ms. Ma was distinguished as the only speaker without a terminal degree selected for the podium session.

5. Teresa Vu, second year student pharmacist SSPPS Role: California Pharmacists Student Leadership (CAPSLEAD) project research advisor. Project Title: “The Search For Quality Over Quantity: The Role of Pharmacists in Reducing Polypharmacy” April 2014 – April 2015

Project was presented as a selected poster at the American Pharmacists Association Annual Meeting. San Diego, CA. March 2015. Abstract published in Journal of the American Pharmacists Association in 2015.

5. Nikki Mulligan, second year student pharmacist SSPPS Role: California Pharmacists Student Leadership (CAPSLEAD) project research advisor. Project Title: “The Search For Quality Over Quantity: The Role of Pharmacists in Reducing Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 7

Polypharmacy” April 2014 – April 2015

7. Crystal Zhou, fourth year student pharmacist SSPPS Role: Project Advisor Project Title: “Demands of student pharmacist inspired programming: challenges and opportunities for small class size pharmacy schools” March – November 2014

Project findings selected for poster presentation at the California Society of Health Systems Pharmacy Annual Meeting. San Francisco, CA. November 2014.

8. Brittany Newton, third year student pharmacist SSPPS Role: Project Advisor Project Title: “Demands of student pharmacist inspired programming: challenges and opportunities for small class size pharmacy schools” March – November 2014

Project findings selected for poster presentation at the California Society of Health Systems Pharmacy Annual Meeting. San Francisco, CA. November 2014.

9. Mark Lin, second year student pharmacist SSPPS Role: Project Advisor Project Title: “Demands of student pharmacist inspired programming: challenges and opportunities for small class size pharmacy schools” March – November 2014

Project findings selected for poster presention at the California Society of Health Systems Pharmacy Annual Meeting. San Francisco, CA. November 2014.

10. Sean Kim, fourth year student pharmacist SSPPS Role: Advanced Pharmacy Practice Elective Preceptor Project Title: “Medication regimen complexity index and Morisky Scale Adherence Correlates” May 2014 – June 2014

11. Hannah Nguyen, third year student pharmacist SSPPS Role: Research Advisor Project Title: Disease progression among Medicare enrollees with atrial fibrillation. April 2015 – Present

Poster presented at AMCP Annual Meeting in San Francisco, CA April 2016.

12. Sammi Tam, third year student pharmacist SSPPS Role: Preceptor and research advisor for Geriatrics Workforce Enhancement Program Collaborative Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 8

Scholars program Project Title: “A review of the recent evidence: high risk medications in the older adult population in the United States” October 2015 – present

Selected for poster presentation at California Pharmacists Association West Coast Exchange. San Francisco, CA. April 2016.

13. Jonathan Chiang, second year student pharmacist SSPPS Role: Faculty advisor to Jonathan Chiang when he was president of AMCP chapter May 2014 – June 2015

UCSD chapter was selected for the AMCP Pharmacy and Therapeutics Competition National Finals in April 2015 in San Diego.

14. Cindy Lau, third year student pharmacist SSPPS Role: Faculty advisor to Cindy Lau when she was president of AMCP chapter June 2015 – May 2016

UCSD chapter took first place in the AMCP Pharmacy and Therapeutics Competition National Finals in April 2016 in San Francisco.

15. Johnny Zhou, third year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Advisor Project Title: “Association between perception on health and total medical expenditure in patients with type II diabetes” June 2015 – October 2015

Project findings presented as a selected poster at California Society of Health Systems Pharmacists Annual Meeting. San Diego, CA. October 2015.

16. Yu Jin, third year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Advisor Project Title: “Impact of FDA approval of self-injectable biologics on biologic utilization in patients with crohn’s disease: analysis of MEPS data from 2003 to 2012.” June 2015 – April 2016

Project findings presented at AMCP Annual Meeting. San Francisco, CA. April 2016.

17. Kathy Linh Nguyen, second year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Advisor (T32 funded) Project Title: “Association between Medication Use for Sleep and Worries about Falls and Limitations of Daily Activities due to Worries in the Older Adults of the United States.” June 2015 – present

Gold Poster Award for abstract: Nguyen KL, Watanabe JH. Risk of emergency department use and hospitalization in patients without access to medications in the US. Academy of Managed Care Pharmacy Annual Meeting. Denver, CO. April 2017. 18. Jamie Ta, third year student pharmacist Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 9

SSPPS Role: Faculty advisor to Jamie Ta in her role as president of AMCP chapter June 2015 – present

Jamie Ta was on the first place team at the National AMCP P&T Competition in 2016. She was also selected for the 2016 AMCP Pfizer Summer Internship with SelectHealth.

19. Samantha Kim, second year student pharmacist SSPPS Role: SSPPS Summer Research Training Program Co-Advisor Project Title: “A Cure for Non-Adherence? Evaluation of Hospital Use and Prescribing Practices when Initiating Long-Acting Injectable Antipsychotics (LAIA)” June 2017 – April 2018

Selected for poster presentation at College of Psychiatric and Neurologic Pharmacists Annual Meeting. Indianopolis, IN. April 2018.

20. Trinh Nguyen, second year student pharmacist SSPPS Role: Research Advisor Project Title: “Examination of residency training for development of advanced-practice pharmacists” June 2017 – present

Student Organization Advisor

2013 – present Academy of Managed Care Pharmacy Student Chapter Faculty Advisor

Geriatrics Workforce Enhancement Program Scholars Program Faculty.

2015 – present Instructor for selected interdisciplinary scholars (nursing, social work, physician, pharmacist, physical therapist, occupations therapist, dentist) for 120 hour training program each year on culturally competent geriatrics care for low-income, border population. 2015 – present.

SPECIAL NATIONAL RESPOSIBILITIES

2006 – 2007 American College of Clinical Pharmacy Student Advisory Committee 2007 American College of Clinical Pharmacy and Health Outcomes and Policy Practice and Research Network. 2014 American Association of the Colleges of Pharmacy Delegate to the Pharmacy Quality Alliance Workgroup on Long Term Care. 2015 American Association of the Colleges of Pharmacy Delegate to the Pharmacy Quality Alliance Measurement Development Team Transitions of Care: Medication Reconciliation in LTC Setting 2014 – 2016 American Academy of Neurology Neurotherapies Workgroup on Pharmacoeconomics 2016 – 2017 National Academy of Sciences, Engineering, and Medicine (ad hoc), Committee on patient access to affordable and effective therapies. 2017 – present Patient-Centered Outcomes Research Institute Research Manuscript reviewer 2018 – present National Academy of Sciences, Engineering, and Medicine Forum on Drug Discovery and Translation. Examining the Impact of Real-World Evidence on Medical Product Development Workshop series. Board on Health Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 10

Sciences Policy. 2018 – present National Academy of Sciences, Engineering, and Medicine ad hoc Committee on National Cancer Control Strategy. Board on Health Care Services.

SPECIAL REGIONAL RESPONSIBILITIES

2005 – 2006 President, Associated Students of the School of Pharmacy, University of Southern California School of Pharmacy 2005 – 2006 USC Committee for Alternative Pharmacist Intern Hours to the California Board of Pharmacy. 2011 Co-Chair, Pharmacoeconomics/ Health Services Student Conference, University of Washington Tower. Seattle, WA. March 31, 2011 – April 2, 2011. 2013 – 2014 UC San Diego SSPPS Educational Policy and Oversight Committee (EPAOC) 2014 – 2015 UC San Diego SSPPS Intern Hours Committee to the California Board of Pharmacy (Senate Bill 590. Signed by Governor Brown August 7, 2015) 2014 – Present UC San Diego SSPPS Faculty Awards Sub-Committee 2014 – 2016 UC San Diego Health Sciences Institutional Review Board Committee C 2014 – 2017 UC San Diego Associated Health Professions Education Committee 2013 – Present Academy of Managed Care Pharmacy Student Chapter Faculty Advisor 2014 – 2017 UC San Diego SSPPS Clinical Faculty Candidate Selection Committee 2015 – present UC San Diego Annual Interprofessional Geriatrics Symposium Steering Committee 2016 – Present UC San Diego & Millennium Health Post-doctoral Research Fellowship in Health Economics, Outcomes Research, and Pharmacogenomics Committee 2014 – Present San Diego Pharmacist Resource and Research Network Academic Advisory Board 2015 – present San Diego Geriatrics Workforce Enhancement Program (SD GWEP) Co- investigator, faculty, and fellowship director 2017 – Present California Health Benefits Review Program for the California Legislature

BIBLIOGRAPHY

Peer Reviewed Manuscripts

1. Campbell JD, Gries KS, Watanabe JH, Ravelo A, Dmochowski RR, Sullivan SD. Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence. BMC Urol. 2009 Nov 20;9:18. doi: 10.1186/1471-2490-9-18. Review. PubMed PMID: 19930578; PubMed Central PMCID: PMC2788579.

2. Watanabe JH, Campbell JD, Ravelo A, Chancellor MB, Kowalski J, Sullivan SD. Cost analysis of interventions for antimuscarinic refractory patients with overactive bladder. Urology. 2010 Oct;76(4):835- 40. doi: 10.1016/j.urology.2010.01.080. PubMed PMID: 20430422.

3. Sand PK, Rovner ES, Watanabe JH, Oefelein MG. Once-daily trospium chloride 60 mg extended release in subjects with overactive bladder syndrome who use multiple concomitant medications: Post hoc analysis of pooled data from two randomized, placebo-controlled trials. Drugs Aging. 2011 Feb 1;28(2):151-60. doi: 10.2165/11586740-000000000-00000. PubMed PMID: 21275440.

4. Patel VD, Watanabe JH, Strauss JA, Dubey AT. Work productivity loss in patients with dry eye disease: an online survey. Curr Med Res Opin. 2011 May;27(5):1041-8. doi: 10.1185/03007995.2011.566264. Epub 2011 Mar 21. PubMed PMID: 21417803.

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 11

5. Watanabe JH, Ney JP. Once-daily generic anticholinergics for overactive bladder: meta-analysis of oxybutynin extended-release randomized trials. Am J Pharm Benefits. 2011;3(5):e85-e92.

6. Ney JP, van der Goes DN, Watanabe JH. Cost-effectiveness of intraoperative neurophysiological monitoring for spinal surgeries: beginning steps. Clin Neurophysiol. 2012 Sep;123(9):1705-7. doi: 10.1016/j.clinph.2012.01.020. Epub 2012 Mar 3. PubMed PMID: 22386320.

7. Watanabe JH, Bounthavong M, Chen T. Revisiting the medication possession ratio threshold for adherence in lipid management. Curr Med Res Opin. 2013 Mar;29(3):175-80. doi: 10.1185/03007995.2013.766164. Epub 2013 Feb 1. PubMed PMID: 23320610.

8. Ney JP, Devine EB, Watanabe JH, Sullivan SD. Comparative efficacy of oral pharmaceuticals for the treatment of chronic peripheral neuropathic pain: meta-analysis and indirect treatment comparisons. Pain Med. 2013 May;14(5):706-19. doi: 10.1111/pme.12091. Epub 2013 Apr 22. PubMed PMID: 23691937.

9. Ney JP, van der Goes DN, Watanabe JH. Cost-benefit analysis: intraoperative neurophysiological monitoring in spinal surgeries. J Clin Neurophysiol. 2013 Jun;30(3):280-6. doi: 10.1097/WNP.0b013e3182933d8f. PubMed PMID: 23733093.

10. Kazerooni R, Watanabe JH, Bounthavong M. Association between statin adherence and cholesterol level reduction from baseline in a veteran population. Pharmacotherapy. 2013 Oct;33(10):1044-1052. doi: 10.1002/phar.1305. Epub 2013 Jun 6. PubMed PMID: 23744794.

11. Kazerooni R, Bounthavong M, Watanabe JH. Association of copayment and statin adherence stratified by socioeconomic status. Ann Pharmacother. 2013 Nov;47(11):1463-70. doi: 10.1177/1060028013505743. Epub 2013 Oct 10. PubMed PMID: 24259605.

12. Watanabe JH, Bounthavong M, Chen T, Ney JP. Association of polypharmacy and statin new-user adherence in a veterans health administration population: a retrospective cohort study. Ann Pharmacother. 2013 Oct;47(10):1253-9. doi:10.1177/1060028013502000. Epub 2013 Oct 21. PubMed PMID: 24259688.

13. Watanabe JH, Kazerooni R, Bounthavong M. Association of copayment with likelihood and level of adherence in new users of statins: a retrospective cohort study. J Manag Care Pharm. 2014 Jan;20(1):43- 50. PubMed PMID: 24372459.

14. Tai BW, Watanabe JH, Law A. Improving medication adherence: from definition to performance. California Pharmacist. Pharmacist. http://www.nxtbook.com/nxtbooks/calpharm/2014spring/#/28. Spring 2014 Issue.

15. Watanabe JH, Ney JP. Association of increased emergency rooms costs for patients without access to necessary medications. Res Social Adm Pharm. 2014 Oct 31. pii: S1551-7411(14)00337-4. doi: 10.1016/j.sapharm.2014.10.007. [Epub ahead of print] PubMed PMID: 25487421.

16. Watanabe JH, Hazlet TK, Sullivan SD. Generic medication utilization policies in the United States and Medicaid sustainability. J Pharm Health Serv Res. 2015. 6: 3–10. doi: 10.1111/jphs.12084

17. Watanabe JH, Chen T, Bounthavong M, Hsu JC. Consideration of new guidelines for cholesterol reduction: comparison of lipid reduction threshold achievement by ACC/AHA benefit groups, Int Lib Diab Metab. 2015. 1(1):13-16. 2015.

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 12

18. Chen T, Hamlett-Berry KW, Watanabe JH, Zillich AJ, Christofferson D, Myers M, Himstreet JE. Evaluation of Multi-disciplinary Tobacco Cessation Training Program in a Large Health Care System. Am Journal Health Educ. 2015;46(3): 165-173, DOI: 10.1080/19325037.2015.1023475 http://dx.doi.org/10.1080/19325037.2015.1023475

19. Alfonso-Cristancho R, Andia T, Barbosa T, Watanabe JH. Definition and classification of generics across the world. Appl Health Econ Health Policy. Appl Health Econ Health Policy. 2015 Aug;13 Suppl 1:S5-11. doi: 10.1007/s40258-014-0146-1. PubMed PMID: 26091708; PubMed Central PMCID: PMC4519628.

20. Bounthavong M, Watanabe JH, Sullivan K. Approach to addressing missing data for electronic medical records and pharmacy claims data research. Pharmacotherapy. 2015 Apr;35(4):380-7. doi: 10.1002/phar.1569. PubMed PMID: 25884526.

21. Dilokthornsakul P, McQueen RB, Spackman DE, Watanabe JH, Campbell JD. Value of Information in Asia: Concepts, Current Use, and Future Directions. Value in Health Regional Issues (ViHRI). 2016 May:99-104.

22. Bounthavong M, Li M, Watanabe JH. An evaluation of health care expenditures in Crohn’s disease using the Medical Expenditure Panel Survey from 2003 to 2013. Res Social Adm Pharm. 2016 May 20. pii: S1551-7411(16)30093-6. doi: 10.1016/j.sapharm.2016.05.042. [Epub ahead of print] PMID: 27263802.

23. Watanabe JH. Medication use, falls, and fall-related worry in older adults in the United States. Consult Pharm. 2016 Jul;31(7):385-93. doi: 10.4140/TCP.n.2016.385. PubMed PMID: 27412315.

24. Park PE, Chau DL, Watanabe JH. Empowering the interdisciplinary care team for improving care in seniors via clinical pharmacy: the San Diego Geriatrics Workforce Enhancement Program. California Pharmacist. April 2017.

25. Tam SHY, Hirsch JD, Watanabe JH. Medication regimen complexity in long-term care facilities and adverse drug events-related hospitalizations. Consult Pharm. 2017 May 1;32(5):281-284. doi: 10.4140/TCP.n.2017.281. PubMed PMID: 28483008.

26. Watanabe JH, McInnis T, Hirsch JD. Cost of drug-related morbidity and mortality. Ann Pharmacother. 2018 Mar 1:1060028018765159. doi: 10.1177/1060028018765159. [Epub ahead of print].

27. Watanabe JH, Chau DL, Hirsch JD. Federal and patient spending on the ten highest spend medications in Medicare Part D from 2011 to 2015. Journal of the American Geriatrics Society. In- press.

28. Nguyen HK, Humber D, Checkoway H, Blanchard D, Watanabe JH. Retrospective cohort analysis of anticoagulant use in high stroke risk patients with non-valvular atrial fibrillation in the United States. Consult Pharm. Accepted.

National Consensus Study Reports

1. Patient access to affordable and effective therapies ad hoc study committee of The National Academy of Sciences, Engineering, and Medicine. National Academies of Sciences, Engineering, and Medicine. 2017. Making Medicines Affordable: A National Imperative. Washington, DC: The National Academies Press. https://doi.org/10.17226/24946. Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 13

Book Chapters

1. Wang Jeffrey, Watanabe JH. Chapter 9: Major ADC development programs, current clinical trials, recent patents, and cost analysis of drug therapy. In: Wang et al., Antibody-drug conjugates: the 21st century magic bullets for cancer. Section IV ADC Landscape, IP and pharmacoeconomics. Springer International Publishing. 2015; pp 153-175.

2. Davidson JE, Watanabe JH, Marshall MF. Evaluation: When Policy Fails. In: O'Keefe M, Yoder-Wise P, eds. Health Policy and Politics. Philadelphia: F.A. Davis. 2017.

Research Abstracts

1. Watanabe JH, Campbell JD, Ravelo A, Chancellor MB, Kowalski J, Sullivan SD. Cost Analysis of Treatments for Antimuscarinic Refractory Patients for Overactive Bladder. SD. American Urological Association Annual Meeting. Orlando, FL. May 2008. [ABSTRACT]

2. Campbell JD, Watanabe JH, Sullivan SD. Smoking and asthma: the additional asthma burden associated with current smokers. International Society of Pharmacoeconomics and Outcomes Research 3rd Annual Asia-Pacific Conference. Seoul, South Korea. September 2008. [ABSTRACT]

3. Rovner E, Dmochowski, R, Watanabe JH. Once daily trospium chloride 60 mg extended release is safe and effective in subjects with the overactive bladder syndrome who use multiple concomitant medications. Society for Urodynamics and Female Urology. Las Vegas, NV. May 2009. [POSTER]

4. Watanabe JH, Campbell JD, Ravelo A, Chancellor MB, Kowalski J, Sullivan SD. Three Year Cost Analysis of Sacral Neuromodulation, Intra-Detrusor Injection of Botulinum Toxin Type A, and Augmentation Cystoplasty for Overactive Bladder with Urinary Urge Incontinence. American Urological Association Annual Meeting. Chicago, IL. April 2009. [POSTER]

5. Watanabe JH, Patel V, Oefelein M. Quantifying At Risk Population in Chronic Overactive Bladder Medication Users in a US Claims Database. AMCP Educational Conference San Antonio, TX. October 2009. [ABSTRACT]

6. Dubey A, Patel V, Strauss J, Watanabe J. Work productivity loss in chronic dry eye disease patients: an online survey. Association for Research in Vision and Opthalmology. Fort Lauderdale, FL. May 2010. [ABSTRACT]

7. Ney JP, Watanabe JH. Impact of gaba-ergic medications on narcotic analgesis use in neuropathic patients. American Association of Neuromuscular and Electrodiagnostic Medicine. Quebec City, Canada. October 2010. [ABSTRACT]

8. Watanabe JH, Ney JP. Association of access to medications and health care utilization: impact on risk of emergency room visit for those unable to obtain medications. American College of Clinical Pharmacy. Austin, TX. October 2010. [ABSTRACT]

9. Globe D, Carlson JJ, Patel H, Colayco D, Hansen R, Watanabe JH, Sullivan SD. Methodological Considerations for Cost-effectiveness Analysis of OnabotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity. ISPOR International Meeting. Baltimore, MD. May 2011. [ABSTRACT]

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 14

10. Watanabe JH, Ney JP, Sullivan SD. Association of Low Income Status and Emergency Room Visits in the US 1999-2008: Comparison of Multivariate and Propensity Score Adjustment. University of Washington School of Pharmacy Corporate Advisory Board Meeting. September 2011. [ABSTRACT]

11. Watanabe JH, Kazerooni R, Bounthavong M. Investigating the association between copayment status and adherence for statin medications in a veterans administration population. AMCP Annual Meeting. San Diego, CA. April 2013. [ABSTRACT]

12. Watanabe JH, Sullivan SD. Impact of copayment escalations on simvastatin users: multi- year longitudinal assessment in the MarketScan Commercial Database. AMCP Annual Meeting. San Diego, CA. April 2013. [ABSTRACT]

13. Bounthavong M, Tran J, Watanabe JH, Chen T. Retrospective cohort study evaluating liraglutide and exenatide in a veteran population. International Society for Pharmacoeconomics and Outcomes Research International Meeting. New Orleans, LA. May 2013. [ABSTRACT]

14. Watanabe JH, Ney JP, Sullivan SD. Properties of propensity score matching procedures on covariate balancing and estimation: influence of the number of propensity score digits used on matched sets created. International Society for Pharmacoeconomics and Outcomes Research International Meeting. New Orleans, LA. May 2013. [ABSTRACT]

15. Ney JP, Watanabe JH. Effect of neurologist ambulatory visits on use of disease-specific pharmacotherapies for chronic neurological conditions. International Society for Pharmacoeconomics and Outcomes Research International Meeting. New Orleans, LA. May 2013. [ABSTRACT]

16. Alfonso-Cristancho R, Watanabe JH. Are generic drugs defined and classified the same across the world. International Society for Pharmacoeconomics and Outcomes Research Latin America Conference. Buenos Aires, Argentina. September 14, 2013. [ABSTRACT]

17. Carlson JJ, Watanabe JH, Boudreau D. Re: Abstract# 1627, Cost impact of Oncotype Dx® breast cancer assay use in a fully integrated healthcare delivery system2013 San Antonio Breast Cancer Symposium. San Antonio, TX. December 10−14, 2013. [ABSTRACT]

18. Chen T, Watanabe J, Cho S, Kazerooni R, Bounthavong M, Myers M. Evaluation of an intensive pharmacist managed telephone tobacco cessation clinic. Society for Research on Nicotine and Tobacco Annual Meeting. February 6, 2014. [ABSTRACT]

19. Watanabe JH, Bounthavong M, Chen T. Comparison of Goal-based versus Percentage- based LDL Reduction Amongst Diabetics. American Diabetes Association 74th Scientific Sessions. June 13-17 2014. San Francisco, CA. [ABSTRACT]

20. Bounthavong M, Watanabe JH, Sullivan KM. Does missing data impact a study's conclusions? An application of multiple imputation. Academy of Health Annual Research Meeting. June 8-10, 2014. San Diego, CA. [ABSTRACT]

21. Ney JP, van der Goes D, Watanabe JH. Pharmaceutical Utilization and expenditures for peripheral neuropathic pain, United States, 2005-2011. International Society for Pharmacoeconomics and Outcomes Research International Meeting. Montreal, QC, Canada. May 31 – June 4 May 2014. [ABSTRACT]

22. Kugler AJ, Watanabe JH, Schwartzman E. Changes in health behaviors of students in the Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 15

first semester of pharmacy school. American Association of Colleges of Pharmacy Annual Meeting. Grapevine, TX. July 8, 2014. [ABSTRACT]

23. Hazlet TK, Watanabe JH. Performance of a student peer assessment rubric over 16 years: correlation with faculty evaluation and grades. American Association of Colleges of Pharmacy Annual Meeting. Grapevine, TX. July 8, 2014. [ABSTRACT]

24. Ma SW, Watanabe JH. Association between Mental Health Status and Medication Access, ER Visits, and Hospitalizations in a Nationally Representative Survey Database". UC San Diego SSPPS Summer Research Program. July 2014. [ABSTRACT]

25. Watanabe JH. Association of ER visits and inability to receive necessary prescription medications. 2014 LS Skaggs Biomedical Research Symposium. University of Montana. Missoula, MT. August 14, 2015. Oral presentation. [ABSTRACT]

26. Hirsch JD, Watanabe JH, LaFleur J, Smith S, Aquilante C, Libby A. Medication Regimen Complexity Index (MRCI): The Skaggs Research Cascade 2014 LS Skaggs Biomedical Research Symposium. University of Montana. Missoula, MT. August 14, 2014.

27. Husain D, Rigas M, Watanabe JH. " Health Services Utilization of Intravenous Immunoglobulin (IVIG): Predictive Variables for Non-Adherence and Adverse Events in IVIG Patients" has been accepted for presentation as a poster during AMCP’s 2014 Nexus meeting in Boston, MA October 9, 2014. [ABSTRACT]

28. Zhou C, Newton B, Lin M, Watanabe JH. Demands of student pharmacist inspired programming: challenges and opportunities for small class size pharmacy schools. California Society of Health Systems Pharmacy Annual Meeting (“Seminar”). San Francisco, CA. November 1, 2014. [ABSTRACT]

29. Vu T, Yang J, Zhou J, Grismer L, Husain D, Mulligan N, Kim S, Chiu C, McBane S, Watanabe JH, Colbert J. The search for quality among quantity: pharmacists involvement in reducing polypharmacy. American Pharmacists Association Annual Meeting. San Diego, CA. March 28, 2015. [ABSTRACT]

30. Watanabe JH, Singh R, Morello C, Hirsch JD, Bounthavong M. Are medicare and medicare- medicaid insulin users different? comparisons in a nationally representative claims database. American Diabetes Association Scientific Sessions. Boston, MA. June 2015. [ABSTRACT]

31. Bounthavong M, Li M, Watanabe JH. An Evaluation of Health Care Expenditures in Crohn’s Disease from 2003 to 2012 Using the US Medical Expenditure Panel Survey. 21st Annual National Research Service Award Meeting 2015. June 13, 2015. Minneapolis, MN. [ABSTRACT]

32. Zhou J, Bounthavong M, Watanabe JH. Association between perception on health and total medical expenditure in patients with type II diabetes. California Society of Health Systems Pharmacists Seminar. San Diego, CA. Oct 11, 2015. [ABSTRACT]

33. Dilokthornsakul P, Watanabe JH, Campbell JD. Value of antidrug antibody screening in moderate-to-severe rheumatoid arthritis patients who failed initial tumor necrosis factor- alpha treatment. International Society for Pharmacoeconomics and Outcomes Research Annual European Congress. Milan, Italy. November 10, 2015. [ABSTRACT]

34. Jin YB, Bounthavong M, Watanabe JH. Impact of FDA approval of self-injectable biologics on biologic utilization in patients with crohn’s disease: analysis of MEPS data from 2003 to Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 16

2012. Academy of Managed Care Pharmacy Annual Meeting. San Francisco, CA. April 20, 2016. [ABSTRACT]

35. Nguyen H, Watanabe JH. Disease progression among Medicare enrollees with atrial fibrillation. Academy of Managed Care Pharmacy Annual Meeting. San Francisco, CA. April 20, 2016. [ABSTRACT]

36. Lau CT, Ma SW, Watanabe JH. Development of Student Pharmacist-assisted Managed Care Elective in a Doctor of Pharmacy Program. Academy of Managed Care Pharmacy Annual Meeting. San Francisco, CA. April 20, 2016. [ABSTRACT]

37. Tam S, Chau D, Watanabe JH. A review of the recent evidence: high risk medications in the older adult population in the United States. California Pharmacists Association West Coast Exchange. San Francisco, CA. April 30, 2016. [ABSTRACT]

38. Nguyen KL, Watanabe JH. Sleep Medication Use and Fall Worry and Worry-related Limitations in US Older Adults. Academy of Managed Care Pharmacy NEXUS. National Harbor, Maryland. October 2016. [ABSTRACT]

39. Watanabe JH. Correlation of pain and pain medication use with insomnia in the nationally representative national health and aging trends study database. Academy of Managed Care Pharmacy Nexus Conference. National Harbor, MD. October 2016. [ABSTRACT]

40. Nguyen KL, Watanabe JH. Risk of emergency department use and hospitalization in patients without access to medications in the US. Academy of Managed Care Pharmacy Annual Meeting. April 2017. [ABSTRACT]

41. Watanabe JH, Saseen J, Dilokthornsakul P, Campbell JD. Utilization, failure, and costs of TNF-alpha inhibitor users in commercial and medicare plans. International Society of Pharmacoeconomics and Outcomes Research International Meeting. Boston, MA. May 2017. [ABSTRACT]

42. Watanabe JH, Chi PB, Chau, DL. Anxiety and Depression Symptoms and Every Night Sleep Medication Use in Older Adults in the United States. Academy of Managed Care Pharmacy Nexus Conference. Grapevine, TX. October 18, 2017. [ABSTRACT].

43. Yang J, Watanabe JH. Prevalence and risk of ‘double-threat’ and ‘triple threat’: association of combination opioid, benzodiazepine, and muscle relaxant usage and emergency department visits in a nationwide US cohort. AMCP Managed Care & Specialty Pharmacy Annual Meeting. Boston, MA. April 25, 2018. [ABSTRACT]

44. Kim S, Crispo-Doherty A, Lee KC, Watanabe JH. Evaluation of hospital use practices when initiating long-acting injectable antipsychotics. College of Psychiatric and Neurologic Pharmacists Annual Meeting. April 23, 2018. Indianapolis, IN. [ABSTRACT]

45. Fitzpatrick C, Di Sano A, Seghal, Sorkin D, Chodos A, Watanabe JH, Chau DL, Lisa Gibbs, MD. GWEP Coordinating Center Networking Meeting. American Geriatrics Society Annual Meeting. Orlando, FL. May 3, 2018. [ABSTRACT]

46. Yang J, Watanabe JH. Longitudinal effect of ‘double-threat’ and ‘triple threat’: association of combination opioid, benzodiazepine, and muscle relaxant usage and emergency Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 17

department visits and hospital discharge in a nationwide US cohort. Pharmacy Quality Alliance Annual Meeting. Baltimore, MD. May 17, 2018. [ABSTRACT]

47. Watanabe JH, Shah M, Bounthavong M. Anxiety and depression symptoms and every night sleep medication use in older adults. Research poster presentations. Session 3. Neurological Disorders. International Society for Pharmacoeconomics and Outcomes Research Asia Pacific Meeting. Tokyo, Japan. September 10, 2018. [ABSTRACT] ACCEPTED.

48. Naderi B, Watanabe JH. Medications in older adults: sometimes less is more. Western Region Chapter, Aging Life Care Association. Annual Conference. San Diego, CA. September 21, 2018. [ABSTRACT]

Selected Presentations

1/06 Resolution to full board for awarding of managed care, industry, and administrative pharmacy internships towards 1500 required hours for pharmacy licensure with. California Board of Pharmacy Public Meeting with Dr. Fred Weissman. Sacramento, CA.

4/06 Alternative Pharmacy Practice Intern Hours. Presenter, California Board of Pharmacy Licensure Committee. Sacramento, CA.

10/06 Presenter, Developing a mail order benefit for DHS. Department of Health Services (DHS) Coverage Initiative Executive Meeting. Los Angeles, CA.

12/06 Serving Patient Needs Through Alternative Pharmacy Practice. California Board of Pharmacy Licensure Committee. Sacramento, CA.

12/11 Impact of Feedback Reports on Prescriber Behavior in Washington State Medicaid. PORPP Department Seminar.

12/12 History and Motivation of the AMCP Dossier Submission Format. AMCP Student Group. Western University College of Pharmacy.

2/13 Study Design and Confounding. Faculty Development Series. Western University College of Pharmacy

4/2/13 Associations of Pharmacy Benefit and Medication Adherence on Utilization and Clinical Endpoints: Applying the Medical Expenditure Panel Survey and Veterans Affairs Database for Inference: Role of Propensity Scores in Observational Data Studies. Invited Talk. UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.

3/1/14 Women’s Leadership Professional Pharmacy Fraternity Lambda Kappa Sigma Spring Residency Workshop Panelist.

3/19/14 Presentation and The California Board of Pharmacy Licensure Committee. Public Session. Proposal to amend intern hours requirements. Sacramento, CA.

4/24/14 Presentation at California Board of Pharmacy. Full Board. Public Session. Proposal to amend intern hours. 4/24/14.

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 18

4/30/14 Review of Study Design and Biostatistics Journal Club Workshop for P3 and P4 students. SSPPS.

5/15/14 Presentation for UCSD Epidemiology fellows. “Revisiting the Medication Possession Ratio for Adherence”.

8/26/14 "Long Term Care Pharmacy Collaborative Care Project: Skaggs School of Pharmacy and Pharmaceutical Sciences and Ron's Pharmacy". Ron’s Pharmacy. San Diego, CA.

8/6/14 “Long Term Pharmacy Policy and Outcomes”. Mercury Pharmacy Services Inc. Mountlake Terrace, WA.

9/19/14 Care improvement in long term care settings via clinical pharmacy. National Centers for Leadership in Academic Medicine final presentation. UC San Diego. September 19, 2014. La Jolla, CA.

10/28/14 Research Methods and Biostatistics. Primer for UC San Diego Medical Center pharmacy residents. UC San Diego Thornton Hospital.

4/15/15 Medication Therapy Management Program for Brookdale Carmel Valley Residents and Families. Brookdale Assisted Living. Carmel Valley, CA.

4/21/15 UC San Diego RxConnections Roundtable Speaker. UC San Diego Price Center.

4/29/15 Family Night Presentation “Medication Therapy Management Program with UC San Diego”. Brookdale Assisted Living, Carmel Valley, CA.

6/4/15 Taste of UCSD Alumni Weekend Presentation. “Keeping the Golden Years Golden”. Calit2. UC San Diego. https://youtu.be/CMWsB8R-H4A

3/9/16 UC San Diego & You with Chancellor Pradeep Khosla. https://youtu.be/O10XAGNEh9M Santa Monica, CA

8/11/16 Advanced STATA Workshop: Time-to-Event Analysis. UCSD SSPPS.

8/29/16 Watanabe JH. Non-Parametric Statistics and Survival Analysis. Touro University College of Pharmacy. Vallejo, CA.

6/17 Watanabe JH. Show Me the Money: Health Economics and Outcomes Research in Historically Challenging Times. Rancho Cordova, VA. Western AMCP Conference. California Northstate University College of Pharmacy.

10/16/17 Integrated Scientific Advice Workshop & Roundtable 2017: Early Multi-Stakeholder Engagement in Product Development: Improving Patient Access in the US and EU.

10/30/17 Kim E, Kruse M, Engelbert J, Watanabe JH. Exploratory analysis of clinical outcomes and economic evaluation of nanosphere varigene with a community hospital antimicrobial stewardship program. UC San Diego Summer Research Forum.

11/1/17 Watanabe JH. Pharmacist contribution to national health policy: National Academy of Medicine Anniversary Fellowship in Pharmacy. UCSD SSPPS Legislative Elective.

12/6/17 Watanabe JH. “Not Letting Them Fall Through the Cracks”. UC San Diego Cross-Cultural Center Faculty-in-Residence Lecture Series. Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 19

12/8/17 Watanabe JH, Talavera G. Geriatric Culturally Competent Care. Geriatric Workforce Enhancement Program (GWEP) Culture of Care Networking Conference. University of California Irvine GWEP. Anaheim, CA.

2/28/18 Panel moderator. “Journeys in Health and Community Wellness” UC San Diego Alumni Women of Color in Health Care. UC San Diego Cross-Cultural Center Faculty-in-Residence Series.

2/27/18 Watanabe JH. “Medications and Older Adults: Proceed with Caution”. Windward Life Care Symposium on Aging Well. February 27, 2018. La Jolla, CA.

3/17/18 Watanabe JH. “Not Letting Them Fall: Medication Considerations and Older Adults”. UCSD Interprofessional Geriatrics Fall Symposium. March 17, 2018. (NEW)

5/25/18 Watanabe JH. Asian Pacific American Heritage Celebration Health Advocacy keynote speaker. UC San Diego Cross-Cultural Center.

International Presentations

1. Watanabe JH. Balancing of Influential Characteristics in Observational Data: A Primer on Propensity Scores. School of Pharmacy Chinese University of Hong Kong. September 4, 2014. Hong Kong, China.

2. Watanabe JH. Pharmacist Contribution at Nursing Home – a Cost Effective Strategy (TBC). The Hong Kong Pharmacy Conference 2015. March 29, 2015. Hong Kong, China.

3. Campbell JD, McQueen RB, Watanabe JH. Expected value of perfect information: active learning through user friendly computations, displays, and asia pacific application discussions. International Society for Pharmacoeconomics and Outocomes Research Asia Biennial Conference. Beijing, China. September 9, 2014. Workshop.

Mass Media

1. ‘What Does it Take to be a Pharmacist?’. Research and Faculty Opportunities. San Diego Society of Health Systems Pharmacists. Interviewed by Dr. Gerald Graf. http://wsradio.com/072114-take- pharmacist/. July 21, 2014.

2. ‘Vaccinations and the Role of the Pharmacist’. The Flu and Public Health Protection by Pharmacists. Interviewed by Dr. Gerald Graf. http://wsradio.com/102014-vaccinations-role-pharmacist/ . October 20, 2014.

3. ‘Drugs to Use with Caution in the Golden Years’. Interviewed by Christina Johnson. UCSD Health Systems News. http://health.ucsd.edu/news/features/Pages/2015-01-09-drugs-to-use-with-caution-as-we- age.aspx

4. Generics utilization policies necessary to sustain Medicaid. http://www.gabionline.net/Generics/Research/Generics-utilization-policies-necessary-to-sustain-Medicaid. March 2015.

5. ‘Keeping the Golden Years Golden’. Taste of UCSD. Pharmaceutical care to improve lives of seniors. UC San Diego Alumni Weekend. https://youtu.be/CMWsB8R-H4A. 6/11/15. Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 20

6. ‘Emergency Rooms Facing Shortages of Important Drugs’. Interviewed by Healthline.com. 2/9/16. Healthline News.

7. ‘Not Letting Them Fall’. UC San Diego and You. Clinical pharmacy programs to reduce falls in older adults in low-income senior primary care clinics. UC San Diego and You Santa Monica

8. ‘Study: Expanding Generic Drug Use Could Save Billions’. Interview by Bradley J. Fikes. San Diego Union-Tribune. http://www.sandiegouniontribune.com/news/2016/may/09/drug-substitution-safely-save- billions/

9. “3 drug classes that more seniors to the ER” https://medshadow.org/features/three-drug-classes-seniors- er/. February 9, 2017.

10. “Rx Comparison Shopping” https://health.ucsd.edu/news/features/Pages/2017-04-24-otc-rx-comparison- shopping.aspx April 24, 2017

11. National Academy of Medicine Names Three NAM Fellows for 2016. http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=10172016e

12. “UWSOP Alumnus Watanabe Named National Academy of Medicine Fellow” https://sop.washington.edu/watanabe-named-national-academy-of-medicine-fellow/ October 17, 2016.

13. Featured in University of Washington Pharmaceutical Outcomes Research and Policy Program Alumni Giving Campaign. http://engage.washington.edu/site/MessageViewer?dlv_id=192312&em_id=199500.0 October 22, 2016.

14. “When Drugs are Wrong Skipped or Make You Sick: The Cost of Non-optimized Meds”. Interview by UCSD Health News https://ucsdnews.ucsd.edu/pressrelease/when_drugs_are_wrong_skipped_or_make_you_sick_the_cost_of _non_optimized_med April 2, 2018

15. “Inaccurate Prescriptions, Usage Costs $528.5 Billion Annually :UCSD Study”. https://www.nbcsandiego.com/news/local/Inaccurate-Prescriptions-Usage-Costs-US-5285-Billion-Annually- UCSD-Study--478591733.html . April 4, 2018.

16. “More than $500 billion wasted in nonoptimized prescriptions”. Interview with Healio https://www.healio.com/family-medicine/pharmacology/news/online/%7B23bdf9bb-eb4b-4f72-8312- 05203b0f0ba9%7D/more-than-500-billion-wasted-in-underutilized-prescriptions . April 9, 2018.

17. “Nonoptimized medication therapy costs U.S. $528.4 billion a year”. http://www.pharmacist.com/article/nonoptimized-medication-therapy-costs-us-5284-billion-year April 16, 2018.

18. “Drugs Cost Billions, Pharmacists Can Help” http://www.drugtopics.com/drug-topics/news/drugs-cost- billions-pharmacists-can-help April 19, 2018.

19. “Medication Management Issues Costs $528 Billion Annually” https://www.openminds.com/market- intelligence/news/medication-errors-interactions-spotty-consumer-adherence-costs-the-united-states-528- billion-annually/ April 29, 2018.

20. “Nonoptimized Drug Therapy Costs More than $500 Billion Annually” https://www.medicalbag.com/finance/annual-drug-therapy-costs/article/758718/

Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 21

21. “Reflection on the NAM Fellowship in Pharmacy | An Interview with the 2016-2018 Fellow, Dr. Jonathan Watanabe”. https://nam.edu/programs/health-policy-educational-programs-and-fellowships/nam-fellowship- in-pharmacy-interview-jonathan-watanabe/ April 17, 2018.

22. Television interview with investigative journalist Mari Payton on NBC 7 Local News on prescription drug costs following White House prescription drug plan blue print release. https://www.nbcsandiego.com/on- air/as-seen-on/Trump_s-Prescription-Plan-Doesn_t-Match-Tough-Talk_-Critics_San-Diego- 482432791.html

CONTRACTS AND GRANTS

1. National UCSD School of 2/14 thru 9/14 Selected new Centers for Medicine investigators (0.6 Leadership in calendar mos) Academic Medicine

2. Skaggs Skaggs 7/1/15 thru 6/30/17 Site PI UCSD SSPPS (1.8 Scholars Foundation calendar mos) Grant University of Colorado Denver

3. Clinical San Diego PACE 7/1/15 thru 6/30/17 Medication Therapeutic Pharmacist Management Pharmacist Consultant SD PACE (2.4 calendar Services mos) Program of All-inclusive Care for the Elderly (PACE)

4. San Diego Human 7/1/15 thru 6/30/19 Co-Investigator (1.8 Geriatrics Resources and calendar mos) Workforce Services Enhancement Administration Grant (SD GWEP)

5. National National Institute 9/1/16 through 8/31/18 Principal Investigator (6 Institutes of on Aging calendar mos) Health Loan Repayment Program

6. National National 10/1/16 through 9/30/18 NAM Fellow (2.4 calendar Academy of Academy of mos) Medicine Sciences, (NAM) Engineering, and Anniversary Medicine Pharmacy Jonathan H. Watanabe, PharmD, MS, PhD, BCGP 22

Fellowship

OTHER

Internships

2004 Walgreens Summer Student Pharmacist Internship, Placentia, CA 2006 Amgen Inc. Graduate Internship,Department of Global Payer Planning, Thousand Oaks, CA

Journal Reviewer Service

2006 – present Journal of Managed Care Pharmacy 2013 – present American Journal of Health Systems Pharmacy 2010 – present American Journal of Pharmacy Benefits 2014 – present Annals of Pharmacotherapy 2014 – present Vascular Health and Risk Management 2014 – present Clinical Journal of Pain 2014 – present American Journal of Managed Care 2015 – present Research in Social and Administrative Pharmacy 2016 – present Clinical Journal of Pain 2016 – present Journal of the American Pharmacists Association

Book Reviews

1. Principles of Research Design and Drug Literature Evaluation. Jones & Bartlett texts. Chapter 12: Regression and Survival Analysis. Published January 2014.

2. Pharmacogenomics: Applications to Patient Care. Third Edition. Section 3: Pharmacogenetics: Other Issues and Implications Chapter 2. Cost-effectiveness, economic incentives and reimbursement issues. Editorial Board Members Julie Johnson, Pharm.D., FCCP, BCPS.Vicki Ellingrod, Pharm.D., FCCP, BCPP. Deanna L. Kroetz, Ph.D. Grace M. Kuo, Pharm.D., MPH, Ph.D. A publication of the American College of Clinical Pharmacy